{ "disease_id": "DOID:0050157", "recommended_name": { "id": "DOID:0050157", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050157", "name": "cryptogenic organizing pneumonia", "description": "An idiopathic interstitial pneumonia characterized by lung inflammation and scarring that obstructs the small airways and air sacs of the lungs (alveoli). A flu-like illness, with a cough, fever, a feeling of illness (malaise), fatigue, and weight loss, heralds the onset in about 50% of people. Frequent presence of crackling sounds (called Velcro crackles) when the doctor listens with a stethoscope." }, "synonyms": [ { "id": "DOID:0050157", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050157", "name": "BOOP", "description": "" }, { "id": "DOID:0050157", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050157", "name": "Cryptogenic organising pneumonitis", "description": "" }, { "id": "DOID:0050157", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050157", "name": "Cryptogenic organizing pneumonitis", "description": "" }, { "id": "DOID:0050157", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050157", "name": "bronchiolitis obliterans organising pneumonia", "description": "" }, { "id": "DOID:0050157", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050157", "name": "bronchiolitis obliterans organizing pneumonia", "description": "" }, { "id": "DOID:0050157", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050157", "name": "cryptogenic organising pneumonia", "description": "" }, { "id": "DOID:0050157", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050157", "name": "idiopathic bronchiolitis obliterans with organizing pneumonia", "description": "" }, { "id": "DOID:0050157", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050157", "name": "idiopathic bronchiolitis obliterans with organising pneumonia", "description": "" } ], "children": [], "id_list": [ "DOID:0050157" ], "unlinked_id_list": [], "crossref": [ { "id": "DOID:0050157", "database": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050157", "categories": [] } ], "proteins": [ { "uniprot_canonical_ac": "P25119-1", "uniprot_ac": "P25119", "uniprot_id": "TNR1B_MOUSE", "refseq_ac": "NP_035740", "glycoprotein": "yes", "species": [ { "name": "Mus musculus", "taxid": 10090, "common_name": "Mouse", "glygen_name": "Mouse", "reference_species": "Mus musculus [10090]" } ], "protein_names": [ { "name": "Tumor necrosis factor receptor superfamily member 1B", "resource": "UniProtKB", "type": "recommended" }, { "name": "TNF-R2", "resource": "UniProtKB", "type": "synonym" }, { "name": "TNF-RII; TNFR-II; p80 TNF-alpha receptor; tumor necrosis factor receptor 2; tumor necrosis factor receptor type II; p75 TNFR; TNF receptor beta chain", "resource": "RefSeq", "type": "synonym" }, { "name": "TNF-RII", "resource": "UniProtKB", "type": "synonym" }, { "name": "TNFR-II", "resource": "UniProtKB", "type": "synonym" }, { "name": "Tumor necrosis factor receptor 2", "resource": "UniProtKB", "type": "synonym" }, { "name": "Tumor necrosis factor receptor type II", "resource": "UniProtKB", "type": "synonym" }, { "name": "p75", "resource": "UniProtKB", "type": "synonym" }, { "name": "p80 TNF-alpha receptor", "resource": "UniProtKB", "type": "synonym" }, { "name": "tumor necrosis factor receptor superfamily member 1B precursor", "resource": "RefSeq", "type": "synonym" } ], "gene_names": [ { "name": "Tnfrsf1b", "resource": "UniProtKB", "type": "recommended" }, { "name": "CD120b; p75; TNF-alphaR2; TNF-R-II; TNF-R2; TNF-R75; TNFalpha-R2; TNFBR; Tnfr-1; Tnfr2; TNFR80; TNFRII", "resource": "RefSeq", "type": "synonym" }, { "name": "Tnfr-2", "resource": "UniProtKB", "type": "synonym" }, { "name": "Tnfr2", "resource": "UniProtKB", "type": "synonym" }, { "name": "Tnfrsf1b", "resource": "RefSeq", "type": "synonym" } ], "evidence": [ { "id": "0050157", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0050157" } ] }, { "uniprot_canonical_ac": "P25118-1", "uniprot_ac": "P25118", "uniprot_id": "TNR1A_MOUSE", "refseq_ac": "NP_035739", "glycoprotein": "yes", "species": [ { "name": "Mus musculus", "taxid": 10090, "common_name": "Mouse", "glygen_name": "Mouse", "reference_species": "Mus musculus [10090]" } ], "protein_names": [ { "name": "Tumor necrosis factor receptor superfamily member 1A", "resource": "UniProtKB", "type": "recommended" }, { "name": "TNF-R1", "resource": "UniProtKB", "type": "synonym" }, { "name": "TNF-RI", "resource": "UniProtKB", "type": "synonym" }, { "name": "TNFR-I", "resource": "UniProtKB", "type": "synonym" }, { "name": "Tumor necrosis factor receptor 1", "resource": "UniProtKB", "type": "synonym" }, { "name": "Tumor necrosis factor receptor type I", "resource": "UniProtKB", "type": "synonym" }, { "name": "p55", "resource": "UniProtKB", "type": "synonym" }, { "name": "p60; TNF-RI; TNFR-I; tumor necrosis factor receptor 1; tumor necrosis factor receptor type I; TNF-alpha-R1; TNF receptor alpha chain", "resource": "RefSeq", "type": "synonym" }, { "name": "p60", "resource": "UniProtKB", "type": "synonym" }, { "name": "tumor necrosis factor receptor superfamily member 1A precursor", "resource": "RefSeq", "type": "synonym" } ], "gene_names": [ { "name": "Tnfrsf1a", "resource": "UniProtKB", "type": "recommended" }, { "name": "CD120a; FPF; p55; p55-R; TNF-alphaR1; TNF-R; TNF-R-I; TNF-R1; TNF-R55; TNFalpha-R1; TNFAR; Tnfr-2; Tnfr1; TNFR60; TNFRI; TNFRp55", "resource": "RefSeq", "type": "synonym" }, { "name": "Tnfr-1", "resource": "UniProtKB", "type": "synonym" }, { "name": "Tnfr1", "resource": "UniProtKB", "type": "synonym" }, { "name": "Tnfrsf1a", "resource": "RefSeq", "type": "synonym" } ], "evidence": [ { "id": "0050157", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0050157" } ] }, { "uniprot_canonical_ac": "P19438-1", "uniprot_ac": "P19438", "uniprot_id": "TNR1A_HUMAN", "refseq_ac": "NP_001056", "glycoprotein": "yes", "species": [ { "name": "Homo sapiens", "taxid": 9606, "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "protein_names": [ { "name": "Tumor necrosis factor receptor superfamily member 1A", "resource": "UniProtKB", "type": "recommended" }, { "name": "TNF-R1", "resource": "UniProtKB", "type": "synonym" }, { "name": "TNF-RI", "resource": "UniProtKB", "type": "synonym" }, { "name": "TNFR-I", "resource": "UniProtKB", "type": "synonym" }, { "name": "Tumor necrosis factor receptor 1", "resource": "UniProtKB", "type": "synonym" }, { "name": "Tumor necrosis factor receptor type I", "resource": "UniProtKB", "type": "synonym" }, { "name": "p55", "resource": "UniProtKB", "type": "synonym" }, { "name": "p60", "resource": "UniProtKB", "type": "synonym" }, { "name": "tumor necrosis factor receptor superfamily member 1A isoform 1 precursor", "resource": "RefSeq", "type": "synonym" }, { "name": "tumor necrosis factor-alpha receptor; tumor necrosis factor binding protein 1; tumor necrosis factor receptor type 1; TNF-R1; TNF-RI; TNFR-I; tumor necrosis factor receptor superfamily member 1A", "resource": "RefSeq", "type": "synonym" } ], "gene_names": [ { "name": "TNFRSF1A", "resource": "UniProtKB", "type": "recommended" }, { "name": "CD120a; FPF; p55; p55-R; p60; TBP1; TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR55; TNFR60", "resource": "RefSeq", "type": "synonym" }, { "name": "TNFAR", "resource": "UniProtKB", "type": "synonym" }, { "name": "TNFR1", "resource": "UniProtKB", "type": "synonym" }, { "name": "TNFRSF1A", "resource": "RefSeq", "type": "synonym" } ], "evidence": [ { "id": "0050157", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0050157" } ] }, { "uniprot_canonical_ac": "P20333-1", "uniprot_ac": "P20333", "uniprot_id": "TNR1B_HUMAN", "refseq_ac": "NP_001057", "glycoprotein": "yes", "species": [ { "name": "Homo sapiens", "taxid": 9606, "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "protein_names": [ { "name": "Tumor necrosis factor receptor superfamily member 1B", "resource": "UniProtKB", "type": "recommended" }, { "name": "TBP-2", "resource": "UniProtKB", "type": "synonym" }, { "name": "TBPII", "resource": "UniProtKB", "type": "synonym" }, { "name": "TNF-R2", "resource": "UniProtKB", "type": "synonym" }, { "name": "TNF-RII", "resource": "UniProtKB", "type": "synonym" }, { "name": "TNFR-II", "resource": "UniProtKB", "type": "synonym" }, { "name": "Tumor necrosis factor receptor 2", "resource": "UniProtKB", "type": "synonym" }, { "name": "Tumor necrosis factor receptor type II", "resource": "UniProtKB", "type": "synonym" }, { "name": "p75", "resource": "UniProtKB", "type": "synonym" }, { "name": "p80 TNF-alpha receptor", "resource": "UniProtKB", "type": "synonym" }, { "name": "tumor necrosis factor beta receptor; tumor necrosis factor binding protein 2; p75 TNF receptor; TNF-R2; TNF-RII; p80 TNF-alpha receptor; tumor necrosis factor receptor 2; tumor necrosis factor receptor type II; tumor necrosis factor receptor superfamily member 1B", "resource": "RefSeq", "type": "synonym" }, { "name": "tumor necrosis factor receptor superfamily member 1B precursor", "resource": "RefSeq", "type": "synonym" } ], "gene_names": [ { "name": "TNFRSF1B", "resource": "UniProtKB", "type": "recommended" }, { "name": "CD120b; p75; p75TNFR; TBPII; TNF-R-II; TNF-R75; TNFBR; TNFR1B; TNFR2; TNFR80", "resource": "RefSeq", "type": "synonym" }, { "name": "TNFBR", "resource": "UniProtKB", "type": "synonym" }, { "name": "TNFR1B", "resource": "UniProtKB", "type": "synonym" }, { "name": "TNFR2", "resource": "UniProtKB", "type": "synonym" }, { "name": "TNFRSF1B", "resource": "RefSeq", "type": "synonym" } ], "evidence": [ { "id": "0050157", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0050157" } ] }, { "uniprot_canonical_ac": "A0A8M2B2L3-1", "uniprot_ac": "A0A8M2B2L3", "uniprot_id": "A0A8M2B2L3_DANRE", "refseq_ac": "XP_005155971", "glycoprotein": "no", "species": [ { "name": "Danio rerio", "taxid": 7955, "common_name": "Zebrafish", "glygen_name": "Zebrafish", "reference_species": "Danio rerio [7955]" } ], "protein_names": [ { "name": "Tumor necrosis factor receptor superfamily member 1B isoform X1", "resource": "UniProtKB", "type": "synonym" }, { "name": "tumor necrosis factor receptor superfamily member 1B isoform X1", "resource": "RefSeq", "type": "synonym" } ], "gene_names": [ { "name": "tnfrsf1b", "resource": "UniProtKB", "type": "recommended" }, { "name": "rank; tnfr2; zgc:163064", "resource": "RefSeq", "type": "synonym" }, { "name": "rank", "resource": "UniProtKB", "type": "synonym" }, { "name": "tnfr2", "resource": "UniProtKB", "type": "synonym" }, { "name": "tnfrsf1b", "resource": "RefSeq", "type": "synonym" }, { "name": "zgc:163064", "resource": "UniProtKB", "type": "synonym" } ], "evidence": [ { "id": "0050157", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0050157" } ] }, { "uniprot_canonical_ac": "Q6NUU6-1", "uniprot_ac": "Q6NUU6", "uniprot_id": "Q6NUU6_DANRE", "refseq_ac": "NP_998355", "glycoprotein": "no", "species": [ { "name": "Danio rerio", "taxid": 7955, "common_name": "Zebrafish", "glygen_name": "Zebrafish", "reference_species": "Danio rerio [7955]" } ], "protein_names": [ { "name": "TNFR1; TNF Receptor 1 (TR1)", "resource": "RefSeq", "type": "synonym" }, { "name": "Tumor necrosis factor receptor superfamily member 1A precursor", "resource": "UniProtKB", "type": "synonym" }, { "name": "Tumor necrosis factor receptor superfamily, member 1a", "resource": "UniProtKB", "type": "synonym" }, { "name": "tumor necrosis factor receptor superfamily member 1A precursor", "resource": "RefSeq", "type": "synonym" } ], "gene_names": [ { "name": "tnfrsf1a", "resource": "UniProtKB", "type": "recommended" }, { "name": "tnfrsf1a", "resource": "RefSeq", "type": "synonym" }, { "name": "wu:fj65b10; zgc:85914", "resource": "RefSeq", "type": "synonym" }, { "name": "wu:fj65b10", "resource": "UniProtKB", "type": "synonym" }, { "name": "zgc:85914", "resource": "UniProtKB", "type": "synonym" } ], "evidence": [ { "id": "0050157", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0050157" } ] }, { "uniprot_canonical_ac": "Q80WY6-1", "uniprot_ac": "Q80WY6", "uniprot_id": "TNR1B_RAT", "refseq_ac": "NP_569110", "glycoprotein": "yes", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "protein_names": [ { "name": "Tumor necrosis factor receptor superfamily member 1B", "resource": "UniProtKB", "type": "recommended" }, { "name": "TNF-R2", "resource": "UniProtKB", "type": "synonym" }, { "name": "TNF-RII", "resource": "UniProtKB", "type": "synonym" }, { "name": "TNFR-II", "resource": "UniProtKB", "type": "synonym" }, { "name": "Tumor necrosis factor receptor 2", "resource": "UniProtKB", "type": "synonym" }, { "name": "Tumor necrosis factor receptor type II", "resource": "UniProtKB", "type": "synonym" }, { "name": "p75; 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p60; TNF-R1; TNF-RI; TNFR-I; tumor necrosis factor receptor 1; tumor necrosis factor receptor type I; tumor necrosis factor receptor superfamily, member 1a", "resource": "RefSeq", "type": "synonym" }, { "name": "p55", "resource": "UniProtKB", "type": "synonym" }, { "name": "p60", "resource": "UniProtKB", "type": "synonym" }, { "name": "tumor necrosis factor receptor superfamily member 1A precursor", "resource": "RefSeq", "type": "synonym" } ], "gene_names": [ { "name": "Tnfrsf1a", "resource": "UniProtKB", "type": "recommended" }, { "name": "TNFR-1; Tnfr1", "resource": "RefSeq", "type": "synonym" }, { "name": "Tnfr-1", "resource": "UniProtKB", "type": "synonym" }, { "name": "Tnfr1", "resource": "UniProtKB", "type": "synonym" }, { "name": "Tnfrsf1a", "resource": "RefSeq", "type": "synonym" } ], "evidence": [ { "id": "0050157", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0050157" } ] } ], "glycans": [], "biomarkers": [], "association_flag": "1000", "record_id": "doid.0050157" }