The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1" ], "evidence": [ { "id": "R-DME-1236398", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-1236398" } ] }, { "id": "R-DME-1247497", "name": "ERBB3 binds neuregulins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1" ], "evidence": [ { "id": "R-DME-1247497", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-1247497" } ] }, { "id": "R-DME-1250195", "name": "SHC1 phosphorylation by ERBB2 heterodimers", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1" ], "evidence": [ { "id": "R-DME-1250195", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-1250195" } ] }, { "id": "R-DME-1250220", "name": "Homodimerization of ERBB4", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1" ], "evidence": [ { "id": "R-DME-1250220", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-1250220" } ] }, { "id": "R-DME-1250315", "name": "Trans-autophosphorylation of ERBB4 homodimers", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1" ], "evidence": [ { "id": "R-DME-1250315", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-1250315" } ] }, { "id": "R-DME-1250348", "name": "Phosphorylation of SHC1 by ERBB4 homodimers", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1" ], "evidence": [ { "id": "R-DME-1250348", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-1250348" } ] }, { "id": "R-DME-1250357", "name": "SHC1 binds P-ERBB4 isoform dimers", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1" ], "evidence": [ { "id": "R-DME-1250357", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-1250357" } ] }, { "id": "R-DME-1250370", "name": "Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1" ], "evidence": [ { "id": "R-DME-1250370", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-1250370" } ] }, { "id": "R-DME-1250380", "name": "Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1" ], "evidence": [ { "id": "R-DME-1250380", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-1250380" } ] }, { "id": "R-DME-1250383", "name": "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1", "P08646-1" ], "evidence": [ { "id": "R-DME-1250383", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-1250383" } ] }, { "id": "R-DME-1250462", "name": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1" ], "evidence": [ { "id": "R-DME-1250462", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-1250462" } ] }, { "id": "R-DME-1251997", "name": "Cleavage of ERBB4m80 by gamma-scretase complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1", "O02194-1" ], "evidence": [ { "id": "R-DME-1251997", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-1251997" } ] }, { "id": "R-DME-1252013", "name": "Translocation of ERBB4s80 to the nucleus", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1", "P00528-1" ], "evidence": [ { "id": "R-DME-1252013", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-1252013" } ] }, { "id": "R-DME-1253282", "name": "ERBB4 ubiquitination by WWP1/ITCH", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1", "Q9Y0H4-1" ], "evidence": [ { "id": "R-DME-1253282", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-1253282" } ] }, { "id": "R-DME-1253300", "name": "ERBB4 binds WWP1/ITCH ubiquitin ligases", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1", "Q9Y0H4-1" ], "evidence": [ { "id": "R-DME-1253300", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-1253300" } ] }, { "id": "R-DME-1253343", "name": "WWOX binds ERBB4s80", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1", "Q9VLU5-1" ], "evidence": [ { "id": "R-DME-1253343", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-1253343" } ] }, { "id": "R-DME-1254285", "name": "ERBB4s80:STAT5A complex translocates to the nucleus", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1" ], "evidence": [ { "id": "R-DME-1254285", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-1254285" } ] }, { "id": "R-DME-1254291", "name": "ERBB4s80 binds STAT5A", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1" ], "evidence": [ { "id": "R-DME-1254291", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-1254291" } ] }, { "id": "R-DME-1254376", "name": "Translocation of cytosolic ERBB4s80 to mitochondrial matrix", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, mitochondrial matrix", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1" ], "evidence": [ { "id": "R-DME-1254376", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-1254376" } ] }, { "id": "R-DME-1254386", "name": "ERBB4s80 forms a complex with estrogen receptor ESR1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1" ], "evidence": [ { "id": "R-DME-1254386", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-1254386" } ] }, { "id": "R-DME-1306957", "name": "PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1" ], "evidence": [ { "id": "R-DME-1306957", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-1306957" } ] }, { "id": "R-DME-1306963", "name": "Binding of GRB2:GAB1 to p-ERBB2:p-EGFR", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1" ], "evidence": [ { "id": "R-DME-1306963", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-1306963" } ] }, { "id": "R-DME-1306969", "name": "GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1" ], "evidence": [ { "id": "R-DME-1306969", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-1306969" } ] }, { "id": "R-DME-1306972", "name": "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1", "P08646-1" ], "evidence": [ { "id": "R-DME-1306972", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-1306972" } ] }, { "id": "R-DME-1306979", "name": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1" ], "evidence": [ { "id": "R-DME-1306979", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-1306979" } ] }, { "id": "R-DME-1358790", "name": "RNF41 ubiquitinates ERBB3", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9VUV7-1", "P04412-1" ], "evidence": [ { "id": "R-DME-1358790", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-1358790" } ] }, { "id": "R-DME-1358792", "name": "RNF41 ubiquitinates activated ERBB3", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9VUV7-1", "P04412-1" ], "evidence": [ { "id": "R-DME-1358792", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-1358792" } ] }, { "id": "R-DME-1358798", "name": "RNF41 binds neuregulin-activated ERBB3", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9VUV7-1", "P04412-1" ], "evidence": [ { "id": "R-DME-1358798", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-1358798" } ] }, { "id": "R-DME-1358801", "name": "ERBB3 binds RNF41 ubiquitin ligase", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9VUV7-1", "P04412-1" ], "evidence": [ { "id": "R-DME-1358801", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-1358801" } ] }, { "id": "R-DME-177922", "name": "EGFR dimerization", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1" ], "evidence": [ { "id": "R-DME-177922", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-177922" } ] }, { "id": "R-DME-177923", "name": "Sustained activation of SRC kinase by SHP2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [ "R-DME-180499" ], "enzyme_list": [ "P04412-1", "P00528-1", "Q8INJ8-1" ], "evidence": [ { "id": "R-DME-177923", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-177923" } ] }, { "id": "R-DME-177924", "name": "Dephosphorylation of Gab1 by SHP2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1" ], "evidence": [ { "id": "R-DME-177924", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-177924" } ] }, { "id": "R-DME-177925", "name": "SHC1 binds to the phosphorylated EGF receptor:ligand complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1" ], "evidence": [ { "id": "R-DME-177925", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-177925" } ] }, { "id": "R-DME-177930", "name": "GAB1 phosphorylation by EGFR kinase", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1" ], "evidence": [ { "id": "R-DME-177930", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-177930" } ] }, { "id": "R-DME-177933", "name": "SHC1 phosphorylation by phosphorylated EGFR", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1" ], "evidence": [ { "id": "R-DME-177933", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-177933" } ] }, { "id": "R-DME-177934", "name": "EGFR autophosphorylation", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1" ], "evidence": [ { "id": "R-DME-177934", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-177934" } ] }, { "id": "R-DME-177935", "name": "SHP2 dephosphorylates Tyr 992 on EGFR", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1" ], "evidence": [ { "id": "R-DME-177935", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-177935" } ] }, { "id": "R-DME-177936", "name": "GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1" ], "evidence": [ { "id": "R-DME-177936", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-177936" } ] }, { "id": "R-DME-177937", "name": "Phosphorylation of EGFR by SRC kinase", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1", "P00528-1" ], "evidence": [ { "id": "R-DME-177937", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-177937" } ] }, { "id": "R-DME-177938", "name": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1", "P08646-1" ], "evidence": [ { "id": "R-DME-177938", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-177938" } ] }, { "id": "R-DME-177939", "name": "PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1" ], "evidence": [ { "id": "R-DME-177939", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-177939" } ] }, { "id": "R-DME-177941", "name": "GRB2:GAB1 binds to phosphorylated EGFR", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1" ], "evidence": [ { "id": "R-DME-177941", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-177941" } ] }, { "id": "R-DME-177942", "name": "EGFR binds EGF ligand", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1" ], "evidence": [ { "id": "R-DME-177942", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-177942" } ] }, { "id": "R-DME-177943", "name": "GRB2:SOS1 complex binds to EGF:EGFR complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1" ], "evidence": [ { "id": "R-DME-177943", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-177943" } ] }, { "id": "R-DME-177945", "name": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1", "P08646-1" ], "evidence": [ { "id": "R-DME-177945", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-177945" } ] }, { "id": "R-DME-182969", "name": "Phosphorylation of CBL (EGFR:CBL)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1", "Q9VSK2-1" ], "evidence": [ { "id": "R-DME-182969", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-182969" } ] }, { "id": "R-DME-182986", "name": "CBL-mediated ubiquitination of CIN85", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1", "Q9VSK2-1" ], "evidence": [ { "id": "R-DME-182986", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-182986" } ] }, { "id": "R-DME-182990", "name": "Sprouty sequesters CBL away from active EGFR", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1", "Q9VSK2-1" ], "evidence": [ { "id": "R-DME-182990", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-182990" } ] }, { "id": "R-DME-182993", "name": "Ubiquitination of stimulated EGFR (CBL)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1", "Q9VSK2-1" ], "evidence": [ { "id": "R-DME-182993", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-182993" } ] }, { "id": "R-DME-182994", "name": "Assembly of EGFR complex in clathrin-coated vesicles", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1", "Q9VSK2-1" ], "evidence": [ { "id": "R-DME-182994", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-182994" } ] }, { "id": "R-DME-183002", "name": "Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1", "P40793-1", "Q9VSK2-1" ], "evidence": [ { "id": "R-DME-183002", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-183002" } ] }, { "id": "R-DME-183036", "name": "Ubiquitination of stimulated EGFR (CBL:GRB2)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1", "Q9VSK2-1" ], "evidence": [ { "id": "R-DME-183036", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-183036" } ] }, { "id": "R-DME-183051", "name": "CBL ubiquitinates Sprouty", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1", "Q9VSK2-1" ], "evidence": [ { "id": "R-DME-183051", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-183051" } ] }, { "id": "R-DME-183055", "name": "Binding of CBL to EGFR", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1", "Q9VSK2-1" ], "evidence": [ { "id": "R-DME-183055", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-183055" } ] }, { "id": "R-DME-183058", "name": "Phosphorylation of CBL (EGFR:GRB2:CBL)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1", "Q9VSK2-1" ], "evidence": [ { "id": "R-DME-183058", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-183058" } ] }, { "id": "R-DME-183067", "name": "Localization of CBL:GRB2 to the membrane", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1", "Q9VSK2-1" ], "evidence": [ { "id": "R-DME-183067", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-183067" } ] }, { "id": "R-DME-183072", "name": "EGFR non-clathrin mediated endocytosis", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1", "Q9VSK2-1" ], "evidence": [ { "id": "R-DME-183072", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-183072" } ] }, { "id": "R-DME-183084", "name": "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1", "P40793-1", "Q9VSK2-1" ], "evidence": [ { "id": "R-DME-183084", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-183084" } ] }, { "id": "R-DME-183089", "name": "CBL binds and ubiquitinates phosphorylated Sprouty", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1", "Q9VSK2-1" ], "evidence": [ { "id": "R-DME-183089", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-183089" } ] }, { "id": "R-DME-1918092", "name": "CHIP (STUB1) mediates ubiquitination of ERBB2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9XYW6-1", "P04412-1" ], "evidence": [ { "id": "R-DME-1918092", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-1918092" } ] }, { "id": "R-DME-1918095", "name": "CUL5 mediates ubiquitination of ERBB2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1" ], "evidence": [ { "id": "R-DME-1918095", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-1918095" } ] }, { "id": "R-DME-1963563", "name": "MATK (CSK homologous kinase) binds phosphorylated ERBB2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1", "Q8INJ8-1" ], "evidence": [ { "id": "R-DME-1963563", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-1963563" } ] }, { "id": "R-DME-1963581", "name": "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1" ], "evidence": [ { "id": "R-DME-1963581", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-1963581" } ] }, { "id": "R-DME-1963582", "name": "Trans-autophosphorylation of ERBB2 heterodimers", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1" ], "evidence": [ { "id": "R-DME-1963582", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-1963582" } ] }, { "id": "R-DME-1963586", "name": "SRC family kinases phosphorylate ERBB2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1", "P00528-1" ], "evidence": [ { "id": "R-DME-1963586", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-1963586" } ] }, { "id": "R-DME-1973956", "name": "NEDD4 binds ERBB4jmAcyt1s80 dimer", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1", "Q9VVI3-1" ], "evidence": [ { "id": "R-DME-1973956", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-1973956" } ] }, { "id": "R-DME-1977296", "name": "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1", "Q9VVI3-1" ], "evidence": [ { "id": "R-DME-1977296", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-1977296" } ] }, { "id": "R-DME-1977958", "name": "ERBB4 forms heterodimers with ERBB3", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1" ], "evidence": [ { "id": "R-DME-1977958", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-1977958" } ] }, { "id": "R-DME-1977959", "name": "ERBB4 forms heterodimers with EGFR", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1" ], "evidence": [ { "id": "R-DME-1977959", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-1977959" } ] }, { "id": "R-DME-212706", "name": "Phospholipase C-gamma1 binds to the activated EGF receptor", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1", "Q9VXH3-1" ], "evidence": [ { "id": "R-DME-212706", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-212706" } ] }, { "id": "R-DME-212710", "name": "EGFR activates PLC-gamma1 by phosphorylation", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1", "Q9VXH3-1" ], "evidence": [ { "id": "R-DME-212710", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-212710" } ] }, { "id": "R-DME-212713", "name": "Active PLC-gamma1 dissociates from EGFR", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1", "Q9VXH3-1" ], "evidence": [ { "id": "R-DME-212713", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-212713" } ] }, { "id": "R-DME-2179407", "name": "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1", "P08646-1" ], "evidence": [ { "id": "R-DME-2179407", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-2179407" } ] }, { "id": "R-DME-2316434", "name": "PI3K phosphorylates PIP2 to PIP3", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1JHB7-1", "P91634-1", "P04412-1", "P00528-1", "Q07407-1", "Q09147-1" ], "evidence": [ { "id": "R-DME-2316434", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-2316434" } ] }, { "id": "R-DME-373750", "name": "SEMA4D interacts with Plexin-B1:ErbB2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1" ], "evidence": [ { "id": "R-DME-373750", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-373750" } ] }, { "id": "R-DME-416588", "name": "Activation of Rho by LARG and PDZ-RhoGEF", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1" ], "evidence": [ { "id": "R-DME-416588", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-416588" } ] }, { "id": "R-DME-416594", "name": "LARG and PDZ-RhoGEF binds to Plexin-B1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1" ], "evidence": [ { "id": "R-DME-416594", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-416594" } ] }, { "id": "R-DME-5672965", "name": "RAS GEFs promote RAS nucleotide exchange", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1JHB7-1", "P04412-1", "A1ZAB3-1", "P00528-1", "P08646-1", "P16621-1", "Q07407-1", "Q09147-1" ], "evidence": [ { "id": "R-DME-5672965", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-5672965" } ] }, { "id": "R-DME-6785636", "name": "Phosphorylated ERBB2 heterodimers bind MEMO1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1" ], "evidence": [ { "id": "R-DME-6785636", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-6785636" } ] }, { "id": "R-DME-6785648", "name": "MEMO1 binds RHOA:GTP:DIAPH1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1" ], "evidence": [ { "id": "R-DME-6785648", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-6785648" } ] }, { "id": "R-DME-8857925", "name": "Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1", "P00528-1", "P23696-1" ], "evidence": [ { "id": "R-DME-8857925", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-8857925" } ] }, { "id": "R-DME-8864125", "name": "PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1" ], "evidence": [ { "id": "R-DME-8864125", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-8864125" } ] }, { "id": "R-DME-8866279", "name": "Epsin family proteins bind ubiquitinated cargo", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1", "Q9VSK2-1" ], "evidence": [ { "id": "R-DME-8866279", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-8866279" } ] }, { "id": "R-DME-8867041", "name": "EGFR phosphorylates EPS15", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1", "Q9VSK2-1" ], "evidence": [ { "id": "R-DME-8867041", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-8867041" } ] }, { "id": "R-DME-8867044", "name": "EGFR binds EPS15, EPN1, EPS15L1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1", "Q9VSK2-1" ], "evidence": [ { "id": "R-DME-8867044", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-8867044" } ] }, { "id": "R-DME-8867047", "name": "PTPN3 dephosphorylates EPS15", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1", "Q9VSK2-1", "Q9W0R3-1" ], "evidence": [ { "id": "R-DME-8867047", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-8867047" } ] }, { "id": "R-DME-8867754", "name": "F- and N- BAR domain proteins bind the clathrin-coated pit", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1", "Q9W2I5-1", "Q7K3H0-1", "Q9VSK2-1" ], "evidence": [ { "id": "R-DME-8867754", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-8867754" } ] }, { "id": "R-DME-8867756", "name": "CLASP proteins and cargo are recruited to the nascent clathrin-coated pit", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1", "Q9W2I5-1", "Q9VSK2-1" ], "evidence": [ { "id": "R-DME-8867756", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-8867756" } ] }, { "id": "R-DME-8868071", "name": "Clathrin recruits PIK3C2A", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1", "Q9W2I5-1", "Q7K3H0-1", "Q9VSK2-1" ], "evidence": [ { "id": "R-DME-8868071", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-8868071" } ] }, { "id": "R-DME-8868072", "name": "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [ "R-ALL-202247" ], "enzyme_list": [ "P04412-1", "Q9W2I5-1", "Q7K3H0-1", "Q9VSK2-1" ], "evidence": [ { "id": "R-DME-8868072", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-8868072" } ] }, { "id": "R-DME-8868236", "name": "BAR domain proteins recruit dynamin", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P02572-1", "P04412-1", "P10987-1", "Q9W2I5-1", "P27619-1", "Q9VSK2-1" ], "evidence": [ { "id": "R-DME-8868236", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-8868236" } ] }, { "id": "R-DME-8868648", "name": "SYNJ hydrolyze PI(4,5)P2 to PI(4)P", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O46094-1", "P02572-1", "P04412-1", "P10987-1", "Q9W2I5-1", "P27619-1", "Q9VSK2-1", "Q5U0V7-1" ], "evidence": [ { "id": "R-DME-8868648", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-8868648" } ] }, { "id": "R-DME-8868651", "name": "Endophilins recruit synaptojanins to the clathrin-coated pit", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O46094-1", "P02572-1", "P04412-1", "P10987-1", "Q9W2I5-1", "P27619-1", "Q9VSK2-1", "Q5U0V7-1" ], "evidence": [ { "id": "R-DME-8868651", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-8868651" } ] }, { "id": "R-DME-8868658", "name": "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "clathrin-coated endocytic vesicle membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O46094-1", "P02572-1", "P04412-1", "P10987-1", "Q9W2I5-1", "P27619-1", "Q9VSK2-1", "Q5U0V7-1" ], "evidence": [ { "id": "R-DME-8868658", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-8868658" } ] }, { "id": "R-DME-8868660", "name": "Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "clathrin-coated endocytic vesicle membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O46094-1", "P02572-1", "P04412-1", "P10987-1", "Q9W2I5-1", "P27619-1", "Q9VSK2-1", "Q5U0V7-1" ], "evidence": [ { "id": "R-DME-8868660", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-8868660" } ] }, { "id": "R-DME-8868661", "name": "Dynamin-mediated GTP hydrolysis promotes vesicle scission", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane, clathrin-coated endocytic vesicle membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O46094-1", "P02572-1", "P04412-1", "P10987-1", "Q9W2I5-1", "P27619-1", "Q9VSK2-1", "Q5U0V7-1" ], "evidence": [ { "id": "R-DME-8868661", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-8868661" } ] }, { "id": "R-DME-8871194", "name": "RAB5 and GAPVD1 bind AP-2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "clathrin-coated endocytic vesicle membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O46094-1", "P02572-1", "P04412-1", "P10987-1", "Q9W2I5-1", "Q9V3I2-1", "P27619-1", "Q9VSK2-1", "Q5U0V7-1" ], "evidence": [ { "id": "R-DME-8871194", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-8871194" } ] }, { "id": "R-DME-8951490", "name": "CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1", "P40793-1", "Q9VSK2-1" ], "evidence": [ { "id": "R-DME-8951490", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-8951490" } ] }, { "id": "R-DME-9612219", "name": "ERBB4s80 binds to SRC", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1", "P00528-1" ], "evidence": [ { "id": "R-DME-9612219", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-9612219" } ] }, { "id": "R-DME-9652264", "name": "ERBB2 binds TKIs", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1" ], "evidence": [ { "id": "R-DME-9652264", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-9652264" } ] }, { "id": "R-DME-9674531", "name": "AAMP binds EGFR", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytoplasm, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04412-1" ], "evidence": [ { "id": "R-DME-9674531", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-9674531" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-202247", "participant_name": "PI(3,4)P2 [plasma membrane]", "crossref": [ { "id": "16152", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-DME-180499", "participant_name": "CSK [plasma membrane]", "crossref": [ { "id": "Q8INJ8", "database": "UniProt", "url": "" }, { "id": "NP_731611.2", "database": "RefSeq", "url": "" }, { "id": "FBgn0262081", "database": "Flybase", "url": "" }, { "id": "NP_001262476.1", "database": "RefSeq", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A1ZAB3", "gene_name": "Ptp52F", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A1ZAB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A1ZAB3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A1ZAB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A1ZAB3" } ] } ] }, { "uniprot_ac": "E1JHB7", "gene_name": "Pvr", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1JHB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E1JHB7" } ] } ] }, { "uniprot_ac": "O02194", "gene_name": "Psn", "activity": [ { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "O02194", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O02194" } ] } ] }, { "uniprot_ac": "O46094", "gene_name": "Ocrl", "activity": [ { "ec_number": "3.1.3.-", "activity": "", "evidence": [ { "id": "O46094", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O46094" } ] }, { "ec_number": "3.1.3.36", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.", "evidence": [ { "id": "O46094", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O46094" } ] } ] }, { "uniprot_ac": "O61444", "gene_name": "Mkk4", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "O61444", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O61444" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "O61444", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O61444" } ] } ] }, { "uniprot_ac": "P00522", "gene_name": "Abl", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00522", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00522" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P00522", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00522" } ] } ] }, { "uniprot_ac": "P00528", "gene_name": "Src64B", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00528", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00528" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P00528", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00528" } ] } ] }, { "uniprot_ac": "P02572", "gene_name": "Act42A", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P02572", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P02572" } ] } ] }, { "uniprot_ac": "P04412", "gene_name": "Egfr", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P04412", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04412" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P04412", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04412" } ] } ] }, { "uniprot_ac": "P08630", "gene_name": "Btk", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P08630", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08630" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P08630", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08630" } ] } ] }, { "uniprot_ac": "P08646", "gene_name": "Ras85D", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P08646", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08646" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P08646", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08646" } ] } ] }, { "uniprot_ac": "P09208", "gene_name": "InR", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P09208", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09208" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P09208", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09208" } ] } ] }, { "uniprot_ac": "P10987", "gene_name": "Act5C", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P10987", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10987" } ] } ] }, { "uniprot_ac": "P13368", "gene_name": "sev", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P13368", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13368" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P13368", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13368" } ] } ] }, { "uniprot_ac": "P16621", "gene_name": "Lar", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P16621", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16621" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P16621", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16621" } ] } ] }, { "uniprot_ac": "P18106", "gene_name": "FER", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P18106", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18106" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P18106", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18106" } ] } ] }, { "uniprot_ac": "P18475", "gene_name": "tor", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P18475", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18475" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P18475", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18475" } ] } ] }, { "uniprot_ac": "P23696", "gene_name": "mts", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P23696", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23696" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P23696", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23696" } ] } ] }, { "uniprot_ac": "P27619", "gene_name": "shi", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P27619", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27619" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "P27619", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27619" } ] } ] }, { "uniprot_ac": "P40793", "gene_name": "Cdc42", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P40793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40793" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P40793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40793" } ] } ] }, { "uniprot_ac": "P49657", "gene_name": "mnb", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P49657", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49657" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P49657", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49657" } ] } ] }, { "uniprot_ac": "P49762", "gene_name": "Doa", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P49762", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49762" } ] }, { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P49762", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49762" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P49762", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49762" } ] } ] }, { "uniprot_ac": "P54350", "gene_name": "Wee1", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P54350", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54350" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P54350", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54350" } ] } ] }, { "uniprot_ac": "P83102", "gene_name": "Dyrk3", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P83102", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P83102" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P83102", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P83102" } ] } ] }, { "uniprot_ac": "P91634", "gene_name": "Pi3K92E", "activity": [ { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "P91634", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P91634" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "P91634", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P91634" } ] }, { "ec_number": "2.7.1.154", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "P91634", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P91634" } ] } ] }, { "uniprot_ac": "Q07407", "gene_name": "htl", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q07407", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07407" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q07407", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07407" } ] } ] }, { "uniprot_ac": "Q09147", "gene_name": "btl", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q09147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q09147" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q09147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q09147" } ] } ] }, { "uniprot_ac": "Q23977", "gene_name": "hep", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q23977", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q23977" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q23977", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q23977" } ] } ] }, { "uniprot_ac": "Q24145", "gene_name": "Shark", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q24145", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q24145" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q24145", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q24145" } ] } ] }, { "uniprot_ac": "Q24324", "gene_name": "Dsor1", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q24324", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q24324" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q24324", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q24324" } ] } ] }, { "uniprot_ac": "Q24488", "gene_name": "Ror", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q24488", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q24488" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q24488", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q24488" } ] } ] }, { "uniprot_ac": "Q24592", "gene_name": "hop", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q24592", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q24592" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q24592", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q24592" } ] } ] }, { "uniprot_ac": "Q27324", "gene_name": "drl", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q27324", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q27324" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q27324", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q27324" } ] } ] }, { "uniprot_ac": "Q5U0V7", "gene_name": "Synj", "activity": [ { "ec_number": "3.1.3.36", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.", "evidence": [ { "id": "Q5U0V7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U0V7" } ] }, { "ec_number": "3.1.3.36", "activity": "", "evidence": [ { "id": "Q5U0V7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U0V7" } ] } ] }, { "uniprot_ac": "Q7K3H0", "gene_name": "Pi3K68D", "activity": [ { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "Q7K3H0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7K3H0" } ] }, { "ec_number": "2.7.1.154", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "Q7K3H0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7K3H0" } ] } ] }, { "uniprot_ac": "Q7KJ08", "gene_name": "Alk", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q7KJ08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7KJ08" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q7KJ08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7KJ08" } ] } ] }, { "uniprot_ac": "Q7KT06", "gene_name": "Ret", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q7KT06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7KT06" } ] } ] }, { "uniprot_ac": "Q8INJ8", "gene_name": "Csk", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q8INJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8INJ8" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q8INJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8INJ8" } ] } ] }, { "uniprot_ac": "Q9I7F7", "gene_name": "Ack-like", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q9I7F7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9I7F7" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q9I7F7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9I7F7" } ] } ] }, { "uniprot_ac": "Q9V3D5", "gene_name": "Dyrk2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q9V3D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9V3D5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q9V3D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9V3D5" } ] } ] }, { "uniprot_ac": "Q9V3I2", "gene_name": "Rab5", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q9V3I2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9V3I2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q9V3I2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9V3I2" } ] } ] }, { "uniprot_ac": "Q9V422", "gene_name": "dnt", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q9V422", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9V422" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q9V422", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9V422" } ] } ] }, { "uniprot_ac": "Q9V6K3", "gene_name": "Nrk", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q9V6K3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9V6K3" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q9V6K3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9V6K3" } ] } ] }, { "uniprot_ac": "Q9V9J3", "gene_name": "Src42A", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q9V9J3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9V9J3" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q9V9J3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9V9J3" } ] } ] }, { "uniprot_ac": "Q9VBW3", "gene_name": "Cad96Ca", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q9VBW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VBW3" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q9VBW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VBW3" } ] } ] }, { "uniprot_ac": "Q9VE06", "gene_name": "cdi", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q9VE06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VE06" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q9VE06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VE06" } ] } ] }, { "uniprot_ac": "Q9VJ04", "gene_name": "Dmel\\CG10702", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q9VJ04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VJ04" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q9VJ04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VJ04" } ] } ] }, { "uniprot_ac": "Q9VLU5", "gene_name": "Wwox", "activity": [ { "ec_number": "1.1.1.-", "activity": "", "evidence": [ { "id": "Q9VLU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VLU5" } ] } ] }, { "uniprot_ac": "Q9VPC0", "gene_name": "Pitslre", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q9VPC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VPC0" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q9VPC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VPC0" } ] } ] }, { "uniprot_ac": "Q9VSK2", "gene_name": "Cbl", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9VSK2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VSK2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9VSK2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VSK2" } ] } ] }, { "uniprot_ac": "Q9VUV7", "gene_name": "elgi", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9VUV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VUV7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9VUV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VUV7" } ] } ] }, { "uniprot_ac": "Q9VVI3", "gene_name": "Nedd4", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating 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"Q9W0R3", "gene_name": "Ptpmeg", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q9W0R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9W0R3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q9W0R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9W0R3" } ] } ] }, { "uniprot_ac": "Q9W2I5", "gene_name": "Dmel\\CG10505", "activity": [ { "ec_number": "3.6.1.3", "activity": "", "evidence": [ { "id": "Q9W2I5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9W2I5" } ] } ] }, { "uniprot_ac": "Q9XYW6", "gene_name": "STUB1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9XYW6", "database": 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