{ "uniprot_canonical_ac": "O77237-1", "uniprot_ac": "O77237", "uniprot_id": "PELI_DROME", "mass": { "chemical_mass": 46770.0, "monoisotopic_mass": 46770.0 }, "refseq": { "ac": "NP_001097890", "name": "pellino, isoform B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001097890" }, "gene_names": [ { "name": "Pli", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O77237", "id": "O77237" }, { "name": "CG5212; Dmel\\CG5212; PAP; pellino; PELLINO; pli", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001097890", "id": "NP_001097890" }, { "name": "CG5212", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O77237", "id": "O77237" }, { "name": "Dmel\\CG5212", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O77237", "id": "O77237" }, { "name": "Dmel_CG5212", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O77237", "id": "O77237" }, { "name": "PAP", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O77237", "id": "O77237" }, { "name": "PELLINO", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O77237", "id": "O77237" }, { "name": "Pli", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001097890", "id": "NP_001097890" }, { "name": "pellino", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O77237", "id": "O77237" }, { "name": "pli", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O77237", "id": "O77237" } ], "protein_names": [ { "name": "Protein pellino", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/O77237/entry#names_and_taxonomy", "id": "O77237" }, { "name": "CG5212-PB; Pli-PB; pelle associated protein; pellino", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001097890", "id": "NP_001097890" }, { "name": "pellino, isoform B", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001097890", "id": "NP_001097890" } ], "function": [ { "annotation": "Scaffold protein involved in the Toll signaling pathway via its interaction with pelle/pll kinase.", "evidence": [ { "database": "UniProtKB", "id": "O77237", "url": "https://www.uniprot.org/uniprot/O77237#function" } ] } ], "disease": [ { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "large intestine cancer", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ], "evidence": [ { "id": "9256", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:9256" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "O77237", "url": "https://www.uniprot.org/uniprot/O77237" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "gene": [ { "name": "Pli", "url": "https://www.uniprot.org/uniprot/O77237", "locus": { "chromosome": "3R", "start_pos": 23860162, "end_pos": 23890052, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "FBgn0025574", "url": "https://www.ensemblgenomes.org/id/FBgn0025574" } ] } } ], "crossref": [ { "id": "FB:FBgn0025574", "url": "https://alliancegenome.org/gene/FB:FBgn0025574", "database": "AGR", "categories": [ "Protein Classification" ] }, { "id": "O77237", "url": "https://alphafold.ebi.ac.uk/entry/O77237", "database": "AlphaFoldDB", "categories": [] }, { "id": "FBgn0025574", "url": "https://bgee.org/?page=gene&gene_id=FBgn0025574", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "FBgn0025574", "url": "https://flybase.org/reports/FBgn0025574", "database": "FlyBase", "categories": [ "Organism-specific" ] }, { "id": "42821", "url": "https://www.ncbi.nlm.nih.gov/gene/42821", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "O77237", "url": "https://www.ebi.ac.uk/intact/interactors/id:O77237*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR006800", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006800", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048334", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048334", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048335", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048335", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "dme:Dmel_CG5212", "url": "https://www.genome.jp/dbget-bin/www_bget?dme:Dmel_CG5212", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "IMHPRGQ", "url": "https://omabrowser.org/oma/group/IMHPRGQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A8JR89", "url": "https://www.orthodb.org/?gene=A8JR89", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "O77237", "url": "https://www.orthodb.org/?gene=O77237", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12098", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12098", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12098:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12098:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04710", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04710", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF20723", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20723", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_O77237", "url": "http://purl.obolibrary.org/obo/PR_O77237", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-DME-9020702", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-9020702", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DME-937039", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-937039", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DME-975144", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-975144", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001097890", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001097890", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A8JR89", "url": "https://www.uniprot.org/uniprot/A8JR89", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A8JR89-1", "url": "https://www.uniprot.org/uniprot/A8JR89-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O77237", "url": "https://www.uniprot.org/uniprot/O77237", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O77237-1", "url": "https://www.uniprot.org/uniprot/O77237-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVKRTDGTESPILAEDGGDGHDKPRLRYGELVILGYNGYLPQGDRGRRRSKFVLHKRTEASGVKRSKHYIVQSPQTSKAILDANQHSISYTLSRNQAVIVEYKEDTETDMFQVGRSSESPIDFVVMDTLPGDKKDAKVMQSTISRFACRILVNRCEPAKARIFAAGFDSSRNIFLGEKATKWQDNVEIDGLTTNGVLIMHPKGSFCGGNAKCGLWRECSVGGDVFSLRESRSAQQKGQPIYDECNILQDGTLIDLCGATLLWRSAEGLQHSPTKHDLEKLIDAINAGRPQCPVGLNTLVIPRKVNIGDQVNQPYVYLNCGHVQGHHDWGQDENTGARRCPMCLELGPVVTLCMGLEPAFYVDVGAPTYAFNPCGHMATEKTVKYWANVEIPHGTNGFQAVCPFCATPLDGATGYIKLIFQDNLD", "length": 424, "header": "sp|O77237-1|PELI_DROME Isoform 1 of Protein pellino OS=Drosophila melanogaster OX=7227 GN=Pli PE=1 SV=1 CANONICAL=O77237-1" }, "isoforms": [ { "isoform_ac": "A8JR89-1", "url": "https://www.uniprot.org/uniprotkb/O77237/entry#A8JR89-1", "sequence": { "sequence": "MVKRTDGTESPILAEDGGDGHDKPRLRYGELVILGYNGYLPQGDRGRRRSKFVLHKRTEASGVKRSKHYIVQSPQTSKAILDANQHSISYTLSRNQAVIVEYKEDTETDMFQVGRSSESPIDFVVMDTLPGDKKDAKVMQSTISRFACRILVNRCEPAKARIFAAGFDSSRNIFLGEKATKWQDNVEIDGLTTNGVLIMHPKGSFCGGNAKCGLWRECSVGGDVFSLRESRSAQQKGQPIYDECNILQDGTLIDLCGATLLWRSAEGLQHSPTKHDLEKLIDAINAGRPQCPVGLNTLVIPRKVNIGDQVNQPYVYLNCGHVQGHHDWGQDENTGARRCPMCLELGPVVTLCMGLEPAFYVDVGAPTYAFNPCGHMATEKTVKYWANVEIPHGTNGFQAVCPFCATPLDGATGYIKLIFQDNLD", "length": 424, "header": "tr|A8JR89-1|A8JR89_DROME Computationally mapped isoform of Pellino, isoform B OS=Drosophila melanogaster OX=7227 GN=Pli PE=3 SV=1 CANONICAL=O77237-1" }, "locus": { "chromosome": "3R", "start_pos": 23889067, "end_pos": 23861382, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0084527", "url": "https://www.ensemblgenomes.org/id/FBtr0084527" }, { "database": "Ensembl Peptide", "id": "FBpp0083913", "url": "https://www.ensemblgenomes.org/id/FBpp0083913" } ] } }, { "isoform_ac": "O77237-1", "url": "https://www.uniprot.org/uniprotkb/O77237/entry#O77237-1", "sequence": { "sequence": "MVKRTDGTESPILAEDGGDGHDKPRLRYGELVILGYNGYLPQGDRGRRRSKFVLHKRTEASGVKRSKHYIVQSPQTSKAILDANQHSISYTLSRNQAVIVEYKEDTETDMFQVGRSSESPIDFVVMDTLPGDKKDAKVMQSTISRFACRILVNRCEPAKARIFAAGFDSSRNIFLGEKATKWQDNVEIDGLTTNGVLIMHPKGSFCGGNAKCGLWRECSVGGDVFSLRESRSAQQKGQPIYDECNILQDGTLIDLCGATLLWRSAEGLQHSPTKHDLEKLIDAINAGRPQCPVGLNTLVIPRKVNIGDQVNQPYVYLNCGHVQGHHDWGQDENTGARRCPMCLELGPVVTLCMGLEPAFYVDVGAPTYAFNPCGHMATEKTVKYWANVEIPHGTNGFQAVCPFCATPLDGATGYIKLIFQDNLD", "length": 424, "header": "sp|O77237-1|PELI_DROME Isoform 1 of Protein pellino OS=Drosophila melanogaster OX=7227 GN=Pli PE=1 SV=1 CANONICAL=O77237-1" }, "locus": { "chromosome": "3R", "start_pos": 23889067, "end_pos": 23861382, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0084527", "url": "https://www.ensemblgenomes.org/id/FBtr0084527" }, { "database": "Ensembl Peptide", "id": "FBpp0083913", "url": "https://www.ensemblgenomes.org/id/FBpp0083913" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "other", "prediction_tool": "", "prediction_tool_list": [ { "label": "" } ], "site_category": "automatic_literature_mining", "site_category_dict": { "automatic_literature_mining": true }, "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 333, "start_aa": "Asn", "end_pos": 333, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn333", "evidence": [ { "id": "38404489", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38404489" }, { "id": "GLY_001400", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001400" }, { "id": "38341922", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38341922" } ], "mining_tool": "GlycoSiteMiner", "mining_tool_list": [ { "label": "GlycoSiteMiner", "url": "https://github.com/glygener/glycositeminer" } ], "filter_code": "00100000000000000000.00010000000000.01.01000" } ], "phosphorylation": [ { "start_pos": 10, "end_pos": 10, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O77237", "url": "https://www.uniprot.org/uniprot/O77237" }, { "database": "PubMed", "id": "18327897", "url": "https://glygen.org/publication/PubMed/18327897" }, { "database": "phospho.ELM", "id": "O77237", "url": "http://phospho.elm.eu.org/byAccession/O77237.html" }, { "database": "iPTMnet", "id": "O77237", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O77237" } ], "site_lbl": "Ser10" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported" ], "publication": [ { "title": "Phosphoproteome analysis of Drosophila melanogaster embryos.", "journal": "Journal of proteome research", "date": "2008", "authors": "Zhai B, Villen J, Beausoleil SA, Mintseris J, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "O77237", "url": "https://www.uniprot.org/uniprot/O77237" }, { "database": "iPTMnet", "id": "O77237", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O77237" } ], "reference": [ { "type": "PubMed", "id": "18327897", "url": "https://glygen.org/publication/PubMed/18327897" } ] }, { "title": "Purification, identification and Cryo-EM structure of prostatic acid phosphatase in human semen.", "journal": "Biochemical and biophysical research communications", "date": "2024-04-02", "authors": "Liu Xuanzhong, Yu Lin, Xia Zhili, Li Jialu, Meng Wenbo, Min Ling, Li Fuping, Wang Xiang", "evidence": [ { "database": "PubMed", "id": "38341922", "url": "https://glygen.org/publication/PubMed/38341922" } ], "reference": [ { "type": "PubMed", "id": "38341922", "url": "https://glygen.org/publication/PubMed/38341922" } ] } ], "pathway": [ { "id": "dme:Dmel_CG5212", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?dme:Dmel_CG5212", "resource": "KEGG Pathway" }, { "id": "R-DME-9020702", "name": "Interleukin-1 signaling", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-9020702", "resource": "Reactome", "description": "Interleukin-1 signaling" }, { "id": "R-DME-937039", "name": "IRAK1 recruits IKK complex", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-937039", "resource": "Reactome", "description": "IRAK1 recruits IKK complex" }, { "id": "R-DME-975144", "name": "IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-975144", "resource": "Reactome", "description": "IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8M2B719-1", "protein_name": "E3 ubiquitin-protein ligase pellino homolog 1 isoform X1", "gene_name": "peli1a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MLSPEQDLLKPVKYGELIVLGYNGSLPNGDRGRRKSRFALFKRPKANGVKPSTVHSTCSAQTARAISNKLQHSVSYTLSRTQTVVVEYTHDSTTDMFQIGRSTESPIDFVVMDTGAGCKANSDTLTSQSTISRFACRIVCQRAPPYTAHIYAAGFDSSKSIFLGEKAAKWWCSDSQMDGLTTNGVLVMRPRHGFTCESKPGPWREISVCGNVFTLRETRSAQKRGKLVEHECHELTDGTLIDLCGATLLWRSAEGLSRTPSLKQLEELRRELNAARPQCPVGLHTLAFPSLQRSIRTSSLQHQPWVYLRCGHVHGYHAWRGRRRVSKHGSTEEEEENEDQMEVQEGEREMVEGERECPLCRTRGLYVPLKLGRESGLYLDGAPPTHAFNPCGHVCSERTAAFWSDLLLPHGAHGFHNACPFCVRPLARDMKCVRLIFQGPLD", "length": 442 }, "evidence": [ { "id": "ZFIN:ZDB-GENE-110310-6", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-110310-6#orthology", "database": "AGR" }, { "id": "HGNC:8827", "url": "https://alliancegenome.org/gene/HGNC:8827#orthology", "database": "AGR" }, { "id": "RGD:1311199", "url": "https://alliancegenome.org/gene/RGD:1311199#orthology", "database": "AGR" }, { "id": "MGI:1914495", "url": "https://alliancegenome.org/gene/MGI:1914495#orthology", "database": "AGR" }, { "id": "FB:FBgn0025574", "url": "https://alliancegenome.org/gene/FB:FBgn0025574#orthology", "database": "AGR" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0JN70-1", "protein_name": "E3 ubiquitin-protein ligase pellino homolog", "gene_name": "PELI1", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MFSPDQENHPSKAPVKYGELIVLGYNGSLPNGDRGRRKSRFALFKRPKANGVKPSTVHVACTPQAAKAISNKDQHSISYTLSRAQTVVVEYTHDSNTDMFQIGRSTESPIDFVVTDTVPGSQSNSDTQSVQSTISRFACRIICERNPPFTARIYAAGFDSSKNIFLGEKAAKWKTSDGQMDGLTTNGVLVMHPRNGFTEDSKPGIWREISVCGNVFSLRETRSAQQRGKMVEIETNQLQDGSLIDLCGATLLWRTAEGLSHTPTVKHLEALRQEINAARPQCPVGFNTLAFPSMKRKDVVDEKQPWVYLHCGHVHGYHNWGNKEERDGKDRECPMCRSVGPYVPLWLGCEAGFYVDAGPPTHAFSPCGHVCSEKTTAYWSQIPLPHGTHTFHAACPFCAHQLAGEQGYIRLIFQGPLD", "length": 418 }, "evidence": [ { "id": "O77237", "url": "https://omabrowser.org/oma/group/O77237/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "A4QN36-1", "protein_name": "Protein pellino homolog 1", "gene_name": "peli1b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MFSPDQENISTSSTKVPVKYGELIVLGYNGSLPNGDRGRRKSRFALFKRPKSNGVKPSTVHVACTPQAAKAISNKDQHSISYTLSRVQTVVVEYTQDSNTDMFQIGRSTESPIDFVVTDTVPGSQSNSDTQSVQSTISRFACRIMCQRTPPYNARIYAAGFDSSKNIFLGEKAAKWKTSDGQMDGLTTNGVLVMHPRHGFTEDSKPGVWREISVCGNVFTLRETRSAQQRGKMVENETQELVDGSLIDLCGATLLWRTAEGLSRTPTIKHLEALRQELNAARPQCPVGFNTLAFPSMRRKDIVDEKQPWVYLNCGHVHGYHNWGNRDAERDGREGRERECPMCRARGPYVPLWLGCEAGFYLDAAPPTHAFSPCGHVCSEKTAAYWSQIPLPHGTHTFHAACPFCAQQLNGEQGYIRLIFQGPVD", "length": 425 }, "evidence": [ { "id": "HGNC:8827", "url": "https://alliancegenome.org/gene/HGNC:8827#orthology", "database": "AGR" }, { "id": "RGD:1311199", "url": "https://alliancegenome.org/gene/RGD:1311199#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-061027-372", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-061027-372#orthology", "database": "AGR" }, { "id": "MGI:1914495", "url": "https://alliancegenome.org/gene/MGI:1914495#orthology", "database": "AGR" }, { "id": "FB:FBgn0025574", "url": "https://alliancegenome.org/gene/FB:FBgn0025574#orthology", "database": "AGR" }, { "id": "O77237", "url": "https://omabrowser.org/oma/group/O77237/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A6HZ09-1", "protein_name": "E3 ubiquitin-protein ligase pellino homolog", "gene_name": "Peli3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVLEGNPEVGSPRTSDLQHPGDKGSCILSSPGEEALPGEEPIKYGELIVLGYNGCLSSGDKGRRRSRLALSRRPHANGVKPDVMHHISTPLVSKALSNRGQHSISYTLSRSHSVIVEYTHDSDKDMFQIGRSTENMIDFVVTDTSPGGGTTEGPSAQSTISRYACRILCDRRPPYTARIYAAGFDASSNIFLGERAAKWRTPDGLMDGLTTNGVLVMHPAGGFSEDSAPGVWREISVCGNVYELRDSRSAQQRGKLVENESNVLQDGSLIDLCGATLLWRTPAGLLRAPTLKQLEAQRQEANAARPQCPVGLSTLAFPSPARGRTAPDKQQPWVYVRCGHVHGYHGWGCRRERGPQERECPLCRLVGPYVPLWLGQEAGLCLDPGPPSHAFAPCGHVCSEKTARYWAQTPLPHGTHAFHAACPFCGAWLTGELGCVRLIFQGPLD", "length": 445 }, "evidence": [ { "id": "ZFIN:ZDB-GENE-110304-4", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-110304-4#orthology", "database": "AGR" }, { "id": "RGD:1305989", "url": "https://alliancegenome.org/gene/RGD:1305989#orthology", "database": "AGR" }, { "id": "MGI:1924963", "url": "https://alliancegenome.org/gene/MGI:1924963#orthology", "database": "AGR" }, { "id": "HGNC:30010", "url": "https://alliancegenome.org/gene/HGNC:30010#orthology", "database": "AGR" }, { "id": "FB:FBgn0025574", "url": "https://alliancegenome.org/gene/FB:FBgn0025574#orthology", "database": "AGR" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A6JQ36-1", "protein_name": "E3 ubiquitin-protein ligase pellino homolog", "gene_name": "Peli1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MFSPDQENHPSKAPVKYGELIVLGYNGSLPNGDRGRRKSRFALFKRPKANGVKPSTVHIACTPQAAKAISNKDQHSISYTLSRAQTVVVEYTHDSNTDMFQIGRSTESPIDFVVTDTVPGSQSNSDTQSVQSTISRFACRIICERNPPFTARIYAAGFDSSKNIFLGEKAAKWKTSDGQMDGLTTNGVLVMHPRDGFTEDSKPGIWREISVCGNVFSLRETRSAQQRGKMVEIETNQLQDGSLIDLCGATLLWRTAEGLSHTPTVKHLEALRQEINAARPQCPVGFNTLAFPSMKRKDVVDEKQPWVYLNCGHVHGYHNWGNKEERDGKDRECPMCRSVGPYVPLWLGCEAGFYVDAGPPTHAFSPCGHVCSEKTTAYWSQIPLPHGTHTFHAACPFCAHQLAGEQGYIRLIFQGPLD", "length": 418 }, "evidence": [ { "id": "ZFIN:ZDB-GENE-110310-6", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-110310-6#orthology", "database": "AGR" }, { "id": "HGNC:8827", "url": "https://alliancegenome.org/gene/HGNC:8827#orthology", "database": "AGR" }, { "id": "RGD:1311199", "url": "https://alliancegenome.org/gene/RGD:1311199#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-061027-372", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-061027-372#orthology", "database": "AGR" }, { "id": "MGI:1914495", "url": "https://alliancegenome.org/gene/MGI:1914495#orthology", "database": "AGR" }, { "id": "FB:FBgn0025574", "url": "https://alliancegenome.org/gene/FB:FBgn0025574#orthology", "database": "AGR" }, { "id": "O77237", "url": "https://omabrowser.org/oma/group/O77237/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3ZSK3-1", "protein_name": "E3 ubiquitin-protein ligase pellino homolog", "gene_name": "Peli2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MFSPGQEEPSSPNKEPVKYGELVVLGYNGALPNGDRGRRKSRFALYKRTKANGVKPSTIHVVSTPQASKAISCKGQHSISYTLSRNQTVVVEYTHDNDTDMFQVGRSTESPIDFVVTDTVSGGQNDDAQITQSTISRFACRIVCDRNEPYTARIFAAGFDSSKNIFLGEKAAKWKNPGGHMDGLTTNGVLVMHPRGGFTDESQPGVWREISVCGDVYTLRETRSAQQRGKLVESETNVLQDGSLIDLCGATLLWRTADGLFHAPTQKHIEALRQEINAARPQCPVGLNTLAFPSINRKEVVEEKQPWAYLSCGHVHGYHSWGHRSDGEANERECPMCRTVGPYVPLWLGCEAGFYVDAGPPTHAFTPCGHVCSEKSAKYWSQIPLPHGTHAFHAACPFCATQLVGEQNCIKLIFQGPVD", "length": 419 }, "evidence": [ { "id": "ZFIN:ZDB-GENE-040718-360", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-040718-360#orthology", "database": "AGR" }, { "id": "MGI:1891445", "url": "https://alliancegenome.org/gene/MGI:1891445#orthology", "database": "AGR" }, { "id": "HGNC:8828", "url": "https://alliancegenome.org/gene/HGNC:8828#orthology", "database": "AGR" }, { "id": "RGD:1565884", "url": "https://alliancegenome.org/gene/RGD:1565884#orthology", "database": "AGR" }, { "id": "FB:FBgn0025574", "url": "https://alliancegenome.org/gene/FB:FBgn0025574#orthology", "database": "AGR" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "E7F7M5-1", "protein_name": "E3 ubiquitin-protein ligase pellino homolog 1-like", "gene_name": "peli3", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MVLEGSSEALCPPPSLELRPSCNKNQSSPPLGSGSQSHDALCPEDKEPIKYGELIVLGHNGSLASGDKGRRRSRLALYKRPKANGVKPDVIHNVSTPLVSKALSNKSQHSISYTLSRSHSVIVEYTHDPNTDMFQIGRSTESMIDFVVTDTASSGGGGQGQGGAGGEGGQSAQSTISRYACRIMCERSAPYTARIYAAGFDSSKNIFLGERAAKWRTSDGLMDGLTTNGVLVMHPAGEFVSEPAPGVWREISVCGNVFALRETRSAQQRGKLVENESNMLQDGSLIDLCGATLLWRTPSGLRHTPTLKQLESLRQELNAARPQCPVGFNTLAFPSLAQRATIDKKQPWVYMNCGHVHGYHNWGFRKEKAGVAAVALTGGGGTAPATTGERECPMCRGVGPYVPLWLGCEGGLYLDAGPPTHAFCPCGHVCSEKTVQGWSQIPLPHGTHAFHAACPFCGTWLTGEQGYIKLIFQGPVD", "length": 477 }, "evidence": [ { "id": "ZFIN:ZDB-GENE-110304-4", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-110304-4#orthology", "database": "AGR" }, { "id": "RGD:1305989", "url": "https://alliancegenome.org/gene/RGD:1305989#orthology", "database": "AGR" }, { "id": "MGI:1924963", "url": "https://alliancegenome.org/gene/MGI:1924963#orthology", "database": "AGR" }, { "id": "HGNC:30010", "url": "https://alliancegenome.org/gene/HGNC:30010#orthology", "database": "AGR" }, { "id": "FB:FBgn0025574", "url": "https://alliancegenome.org/gene/FB:FBgn0025574#orthology", "database": "AGR" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "G3H131-1", "protein_name": "E3 ubiquitin-protein ligase pellino homolog", "gene_name": "Peli1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MFSPDQENHPSKAPVKYGELIVLGYNGSLPNGDRGRRKSRFALFKRPKANGVKPSTVHIACTPQAAKAISNKDQHSISYTLSRAQTVVVEYTHDSNTDMFQIGRSTESPIDFVVTDTVPGSQSNSDTQSVQSTISRFACRIICERNPPFTARIYAAGFDSSKNIFLGEKAAKWKTSDGQMDGLTTNGVLVMHPRNGFTEDSKPGIWREISVCGNVFSLRETRSAQQRGKMVEIETNQLQDGSLIDLCGATLLWRTAEGLSHTPTVKHLEALRQEINAARPQCPVGFNTLAFPSMKRKDVVDEKQPWVYLNCGHVHGYHNWGNKEERDGKDRECPMCRSVGPYVPLWLGCEAGFYVDAGPPTHAFSPCGHVCSEKTTAYWSQIPLPHGTHTFHAACPFCAHQLAGEQGYIRLIFQGPLD", "length": 418 }, "evidence": [ { "id": "O77237", "url": "https://omabrowser.org/oma/group/O77237/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q6DHJ8-1", "protein_name": "Pellino homolog 2 (Drosophila)", "gene_name": "peli2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MFSPGQEEHCAPTKEPVKYGELVVLGYNGSLPNGDRGRRKSRFALYKRAKANGVKPSTVHILNTPQASKAVNCKGQHSISYTLSRNQTVVVEYSHDKDTDMFQIGRSTEGPIDFVVTDTVSGGGESEETPITQSTISRFACRVVCERNPPYTARIFAAGFDSSKNIFLGEKAAKWKNPDGHMDGLTTNGVLVMHPRGGFTEESKPGVWREISVCGDVYTLRETRSAQTRGKLVESESNVLQDGSLVDLCGATLLWRTADGLFHTPTQKHLEALRQELNAARPQCPVGLNTLAFPSMQRCSRALSNVPAQEDKQPWVYLACGHVHGYHDWGHRSERESNAQRECPMCRAVGPYVPLWLGCEPAFYVDTGAPTHVFVPCGHVCSEKSTRYWAEIPLPHGTHAFHAACPFCATQLNLTQKWAKLIFQGPID", "length": 428 }, "evidence": [ { "id": "ZFIN:ZDB-GENE-040718-360", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-040718-360#orthology", "database": "AGR" }, { "id": "MGI:1891445", "url": "https://alliancegenome.org/gene/MGI:1891445#orthology", "database": "AGR" }, { "id": "HGNC:8828", "url": "https://alliancegenome.org/gene/HGNC:8828#orthology", "database": "AGR" }, { "id": "RGD:1565884", "url": "https://alliancegenome.org/gene/RGD:1565884#orthology", "database": "AGR" }, { "id": "FB:FBgn0025574", "url": "https://alliancegenome.org/gene/FB:FBgn0025574#orthology", "database": "AGR" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q8BST6-1", "protein_name": "E3 ubiquitin-protein ligase pellino homolog 2", "gene_name": "Peli2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFSPGQEEPSAPNKEPVKYRELVVLGYNGALPNGDRGRRKSRFALYKRTYASGVKPSTIHMVSTPQASKAISSRGHHSISYTLSRSQTVVVEYTHDKDTDMFQVGRSTESPIDFVVTDTVSGGQNEDAQITQSTISRFACRIVCDRNEPYTARIFAAGFDSSKNIFLGEKAAKWKNPDGHMDGLTTNGVLVMHPQGGFTEESQPGVWREISVCGDVYTLRETRSAQQRGKLVESETNVLQDGSLIDLCGATLLWRTADGLFHAPTQKHIEALRQEINAARPQCPVGLNTLAFPSINRKEVVEEKQPWAYLSCGHVHGYHSWGHRSDTEANERECPMCRTVGPYVPLWLGCEAGFYVDAGPPTHAFTPCGHVCSEKSAKYWSQIPLPHGTHAFHAACPFCATQLVGEQNCIKLIFQGPVD", "length": 419 }, "evidence": [ { "id": "ZFIN:ZDB-GENE-040718-360", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-040718-360#orthology", "database": "AGR" }, { "id": "MGI:1891445", "url": "https://alliancegenome.org/gene/MGI:1891445#orthology", "database": "AGR" }, { "id": "HGNC:8828", "url": "https://alliancegenome.org/gene/HGNC:8828#orthology", "database": "AGR" }, { "id": "RGD:1565884", "url": "https://alliancegenome.org/gene/RGD:1565884#orthology", "database": "AGR" }, { "id": "FB:FBgn0025574", "url": "https://alliancegenome.org/gene/FB:FBgn0025574#orthology", "database": "AGR" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8BXR6-1", "protein_name": "E3 ubiquitin-protein ligase pellino homolog 3", "gene_name": "Peli3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVLEGNPDVGSPRTSDLQHPGSQGSCILSCPGEEALAGEEPIKYGELIVLGYNGCLASGDKGRRRSRLALSRRPHANGVKPDVMHHISTPLVSKALSNRGQHSISFTLSRSHSVIVEYTHDSDKDMFQIGRSTENMIDFVVTDTSPGGGATEGPSAQSTISRYACRILCDRRPPYTARIYAAGFDASSNIFLGERAAKWRTPDGLMDGLTTNGVLVMHPAGGFSEDSAPGVWREISVCGNVYTLRDSRSAQQRGKLVENESNVLQDGSLIDLCGATLLWRTPAGLLRAPTLKQLEAQRQEANAARPQCPVGLSTLAFPSPARGRTAPDKQQPWVYVRCGHVHGYHGWGCRRERGPQERECPLCRLVGPYVPLWLGQEAGLCLDPGPPSHAFAPCGHVCSEKTARYWAQTPLPHGTHAFHAACPFCGAWLTGELGCVRLIFQGPLD", "length": 445 }, "evidence": [ { "id": "ZFIN:ZDB-GENE-110304-4", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-110304-4#orthology", "database": "AGR" }, { "id": "RGD:1305989", "url": "https://alliancegenome.org/gene/RGD:1305989#orthology", "database": "AGR" }, { "id": "MGI:1924963", "url": "https://alliancegenome.org/gene/MGI:1924963#orthology", "database": "AGR" }, { "id": "HGNC:30010", "url": "https://alliancegenome.org/gene/HGNC:30010#orthology", "database": "AGR" }, { "id": "FB:FBgn0025574", "url": "https://alliancegenome.org/gene/FB:FBgn0025574#orthology", "database": "AGR" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8C669-1", "protein_name": "E3 ubiquitin-protein ligase pellino homolog 1", "gene_name": "Peli1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFSPDQENHPSKAPVKYGELIVLGYNGSLPNGDRGRRKSRFALFKRPKANGVKPSTVHIACTPQAAKAISNKDQHSISYTLSRAQTVVVEYTHDSNTDMFQIGRSTESPIDFVVTDTVPGSQSNSDTQSVQSTISRFACRIICERSPPFTARIYAAGFDSSKNIFLGEKAAKWKTSDGQMDGLTTNGVLVMHPRNGFTEDSKPGIWREISVCGNVFSLRETRSAQQRGKMVEIETNQLQDGSLIDLCGATLLWRTAEGLSHTPTVKHLEALRQEINAARPQCPVGFNTLAFPSMKRKDVVDEKQPWVYLNCGHVHGYHNWGNKEERDGKDRECPMCRSVGPYVPLWLGCEAGFYVDAGPPTHAFSPCGHVCSEKTTAYWSQIPLPHGTHTFHAACPFCAHQLAGEQGYIRLIFQGPLD", "length": 418 }, "evidence": [ { "id": "ZFIN:ZDB-GENE-110310-6", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-110310-6#orthology", "database": "AGR" }, { "id": "HGNC:8827", "url": "https://alliancegenome.org/gene/HGNC:8827#orthology", "database": "AGR" }, { "id": "RGD:1311199", "url": "https://alliancegenome.org/gene/RGD:1311199#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-061027-372", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-061027-372#orthology", "database": "AGR" }, { "id": "MGI:1914495", "url": "https://alliancegenome.org/gene/MGI:1914495#orthology", "database": "AGR" }, { "id": "FB:FBgn0025574", "url": "https://alliancegenome.org/gene/FB:FBgn0025574#orthology", "database": "AGR" }, { "id": "O77237", "url": "https://omabrowser.org/oma/group/O77237/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8N2H9-1", "protein_name": "E3 ubiquitin-protein ligase pellino homolog 3", "gene_name": "PELI3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVLEGNPEVGSPRTSDLQHRGNKGSCVLSSPGEDAQPGEEPIKYGELIVLGCCEEGGEETEAQRGEVTGPRAHSCYNGCLASGDKGRRRSRLALSRRSHANGVKPDVMHHISTPLVSKALSNRGQHSISYTLSRSHSVIVEYTHDSDTDMFQIGRSTENMIDFVVTDTSPGGGAAEGPSAQSTISRYACRILCDRRPPYTARIYAAGFDASSNIFLGERAAKWRTPDGLMDGLTTNGVLVMHPAGGFSEDSAPGVWREISVCGNVYTLRDSRSAQQRGKLVENESNVLQDGSLIDLCGATLLWRTPAGLLRAPTLKQLEAQRQEANAARPQCPVGLSTLAFPSPARGRTAPDKQQPWVYVRCGHVHGYHGWGCRRERGPQERECPLCRLVGPYVPLWLGQEAGLCLDPGPPSHAFAPCGHVCSEKTARYWAQTPLPHGTHAFHAACPFCGAWLTGEHGCVRLIFQGPLD", "length": 469 }, "evidence": [ { "id": "ZFIN:ZDB-GENE-110304-4", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-110304-4#orthology", "database": "AGR" }, { "id": "RGD:1305989", "url": "https://alliancegenome.org/gene/RGD:1305989#orthology", "database": "AGR" }, { "id": "MGI:1924963", "url": "https://alliancegenome.org/gene/MGI:1924963#orthology", "database": "AGR" }, { "id": "HGNC:30010", "url": "https://alliancegenome.org/gene/HGNC:30010#orthology", "database": "AGR" }, { "id": "FB:FBgn0025574", "url": "https://alliancegenome.org/gene/FB:FBgn0025574#orthology", "database": "AGR" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q96FA3-1", "protein_name": "E3 ubiquitin-protein ligase pellino homolog 1", "gene_name": "PELI1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MFSPDQENHPSKAPVKYGELIVLGYNGSLPNGDRGRRKSRFALFKRPKANGVKPSTVHIACTPQAAKAISNKDQHSISYTLSRAQTVVVEYTHDSNTDMFQIGRSTESPIDFVVTDTVPGSQSNSDTQSVQSTISRFACRIICERNPPFTARIYAAGFDSSKNIFLGEKAAKWKTSDGQMDGLTTNGVLVMHPRNGFTEDSKPGIWREISVCGNVFSLRETRSAQQRGKMVEIETNQLQDGSLIDLCGATLLWRTAEGLSHTPTVKHLEALRQEINAARPQCPVGFNTLAFPSMKRKDVVDEKQPWVYLNCGHVHGYHNWGNKEERDGKDRECPMCRSVGPYVPLWLGCEAGFYVDAGPPTHAFSPCGHVCSEKTTAYWSQIPLPHGTHTFHAACPFCAHQLAGEQGYIRLIFQGPLD", "length": 418 }, "evidence": [ { "id": "ZFIN:ZDB-GENE-110310-6", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-110310-6#orthology", "database": "AGR" }, { "id": "HGNC:8827", "url": "https://alliancegenome.org/gene/HGNC:8827#orthology", "database": "AGR" }, { "id": "RGD:1311199", "url": "https://alliancegenome.org/gene/RGD:1311199#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-061027-372", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-061027-372#orthology", "database": "AGR" }, { "id": "MGI:1914495", "url": "https://alliancegenome.org/gene/MGI:1914495#orthology", "database": "AGR" }, { "id": "FB:FBgn0025574", "url": "https://alliancegenome.org/gene/FB:FBgn0025574#orthology", "database": "AGR" }, { "id": "O77237", "url": "https://omabrowser.org/oma/group/O77237/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9HAT8-1", "protein_name": "E3 ubiquitin-protein ligase pellino homolog 2", "gene_name": "PELI2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MFSPGQEEHCAPNKEPVKYGELVVLGYNGALPNGDRGRRKSRFALYKRPKANGVKPSTVHVISTPQASKAISCKGQHSISYTLSRNQTVVVEYTHDKDTDMFQVGRSTESPIDFVVTDTISGSQNTDEAQITQSTISRFACRIVCDRNEPYTARIFAAGFDSSKNIFLGEKAAKWKNPDGHMDGLTTNGVLVMHPRGGFTEESQPGVWREISVCGDVYTLRETRSAQQRGKLVESETNVLQDGSLIDLCGATLLWRTADGLFHTPTQKHIEALRQEINAARPQCPVGLNTLAFPSINRKEVVEEKQPWAYLSCGHVHGYHNWGHRSDTEANERECPMCRTVGPYVPLWLGCEAGFYVDAGPPTHAFTPCGHVCSEKSAKYWSQIPLPHGTHAFHAACPFCATQLVGEQNCIKLIFQGPID", "length": 420 }, "evidence": [ { "id": "ZFIN:ZDB-GENE-040718-360", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-040718-360#orthology", "database": "AGR" }, { "id": "MGI:1891445", "url": "https://alliancegenome.org/gene/MGI:1891445#orthology", "database": "AGR" }, { "id": "HGNC:8828", "url": "https://alliancegenome.org/gene/HGNC:8828#orthology", "database": "AGR" }, { "id": "RGD:1565884", "url": "https://alliancegenome.org/gene/RGD:1565884#orthology", "database": "AGR" }, { "id": "FB:FBgn0025574", "url": "https://alliancegenome.org/gene/FB:FBgn0025574#orthology", "database": "AGR" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "O77237", "url": "https://www.uniprot.org/uniprot/O77237" } ], "pmid": "" }, { "name": "ubiquitin-protein transferase activity", "id": "GO:0004842", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004842", "evidence": [ { "database": "UniProtKB", "id": "O77237", "url": "https://www.uniprot.org/uniprot/O77237" } ], "pmid": "" }, { "name": "kinase regulator activity", "id": "GO:0019207", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019207", "evidence": [ { "database": "UniProtKB", "id": "O77237", "url": "https://www.uniprot.org/uniprot/O77237" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 9, "go_terms": [ { "name": "protein polyubiquitination", "id": "GO:0000209", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000209", "evidence": [ { "database": "UniProtKB", "id": "O77237", "url": "https://www.uniprot.org/uniprot/O77237" } ], "pmid": "" }, { "name": "regulation of Toll signaling pathway", "id": "GO:0008592", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008592", "evidence": [ { "database": "UniProtKB", "id": "O77237", "url": "https://www.uniprot.org/uniprot/O77237" } ], "pmid": "" }, { "name": "negative regulation of antifungal innate immune response", "id": "GO:1905035", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905035", "evidence": [ { "database": "UniProtKB", "id": "O77237", "url": "https://www.uniprot.org/uniprot/O77237" } ], "pmid": "" }, { "name": "innate immune response", "id": "GO:0045087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "evidence": [ { "database": "UniProtKB", "id": "O77237", "url": "https://www.uniprot.org/uniprot/O77237" } ], "pmid": "" }, { "name": "protein K48-linked ubiquitination", "id": "GO:0070936", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070936", "evidence": [ { "database": "UniProtKB", "id": "O77237", "url": "https://www.uniprot.org/uniprot/O77237" } ], "pmid": "" }, { "name": "negative regulation of defense response to bacterium", "id": "GO:1900425", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900425", "evidence": [ { "database": "UniProtKB", "id": "O77237", "url": "https://www.uniprot.org/uniprot/O77237" } ], "pmid": "" }, { "name": "negative regulation of Toll signaling pathway", "id": "GO:0045751", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045751", "evidence": [ { "database": "UniProtKB", "id": "O77237", "url": "https://www.uniprot.org/uniprot/O77237" } ], "pmid": "" }, { "name": "positive regulation of antimicrobial peptide production", "id": "GO:0002225", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002225", "evidence": [ { "database": "UniProtKB", "id": "O77237", "url": "https://www.uniprot.org/uniprot/O77237" } ], "pmid": "" }, { "name": "positive regulation of Toll signaling pathway", "id": "GO:0045752", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045752", "evidence": [ { "database": "UniProtKB", "id": "O77237", "url": "https://www.uniprot.org/uniprot/O77237" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "O77237", "url": "https://www.uniprot.org/uniprot/O77237" } ], "pmid": "" }, { "name": "cytoplasmic side of plasma membrane", "id": "GO:0009898", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009898", "evidence": [ { "database": "UniProtKB", "id": "O77237", "url": "https://www.uniprot.org/uniprot/O77237" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-O77237-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 424, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-O77237-F1.pdb" } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.agr", "label": "AGR Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 333 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 10 ], "sequon_annotation_sites": [] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "prediction_tool", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl", "mining_tool" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "prediction_tool", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl", "mining_tool" ] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }