{ "uniprot_canonical_ac": "A0A1P8AV25-1", "uniprot_ac": "A0A1P8AV25", "uniprot_id": "A0A1P8AV25_ARATH", "mass": { "chemical_mass": 142134.0, "monoisotopic_mass": 142134.0 }, "refseq": { "ac": "NP_001322805", "name": "RAD3-like DNA-binding helicase protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001322805" }, "gene_names": [ { "name": "F2D10.21; F2D10_21", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001322805", "id": "NP_001322805" }, { "name": "F2D10.21", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A1P8AV25", "id": "A0A1P8AV25" }, { "name": "F2D10_21", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A1P8AV25", "id": "A0A1P8AV25" } ], "protein_names": [ { "name": "RAD3-like DNA-binding helicase protein", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001322805", "id": "NP_001322805" }, { "name": "RAD3-like DNA-binding helicase protein", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A1P8AV25/entry#names_and_taxonomy", "id": "A0A1P8AV25" } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Arabidopsis thaliana", "taxid": 3702, "evidence": [ { "database": "UniProtKB", "id": "A0A1P8AV25", "url": "https://www.uniprot.org/uniprot/A0A1P8AV25" } ], "common_name": "Mouse-ear cress", "glygen_name": "Arabidopsis", "reference_species": "Arabidopsis thaliana [3702]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprot/A0A1P8AV25", "locus": {} } ], "crossref": [ { "id": "A0A1P8AV25", "url": "https://alphafold.ebi.ac.uk/entry/A0A1P8AV25", "database": "AlphaFoldDB", "categories": [] }, { "id": "AT1G20720", "url": "https://bar.utoronto.ca/thalemine/portal.do?externalids=AT1G20720", "database": "Araport", "categories": [ "Protein", "Organism-specific" ] }, { "id": "cd18788", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18788", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "838662", "url": "https://www.ncbi.nlm.nih.gov/gene/838662", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006554", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006554", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006555", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006555", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010614", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010614", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014013", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014013", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045028", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045028", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "ath:AT1G20720", "url": "https://www.genome.jp/dbget-bin/www_bget?ath:AT1G20720", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FSNDNAR", "url": "https://omabrowser.org/oma/group/FSNDNAR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A1P8AV25", "url": "https://www.orthodb.org/?gene=A0A1P8AV25", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11472", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11472", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11472:SF47", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11472:SF47", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06733", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06733", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF13307", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13307", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "NP_001322805", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001322805", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "AT1G20720", "url": "https://www.arabidopsis.org/servlets/TairObject?type=locus&name=AT1G20720", "database": "TAIR", "categories": [ "Protein", "Organism-specific" ] }, { "id": "A0A1P8AV25", "url": "https://www.uniprot.org/uniprot/A0A1P8AV25", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1P8AV25-1", "url": "https://www.uniprot.org/uniprot/A0A1P8AV25-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F4HUN4", "url": "https://www.uniprot.org/uniprot/F4HUN4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F4HUN4-1", "url": "https://www.uniprot.org/uniprot/F4HUN4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVSSTSKSDSKEEVKQTLNSKNPKNVYQIGGLQVEFPYQPYGTQLAFMSRVISTLDRAQRDGHCHALLESPTGTGKSLSLLCSVLAWQQNYKSRLLKGNLSHSKAAPEAATDPLNHGGGFIPETQPSDTPASTNVEKAETATKKRTKIPTIYYASRTHSQITQVIREYRKTGYRVPMAVLASRKHYCTNRHVLGKDNVDDECRLLLKDKANIQCSEFKNVNKITSHPSLQPRGHNEVHDIEDLVKVGKNVRGCPYFASWSMAENAQLVFCPYSYIVNPVIRAGVEVDLKGAIIIFDEAHNMEDIAREAGSINLEEDTLFKLQNELEQMSVAQPMIYQPLCEVVEGLISWIGRKKDSLAKRDFQHYFSSWTGDKALRELEESNITRECFPILLECFTKAIRTSKEAEMESDMLYLSGISVLTLEELFSSLTYFFSRNGSHILDYQLGLQRSTKRGDPSGTWTHTFSLWCMNPAVVFKDLADISLSVILTSGTLSPMNSFSSELGMQFGTSLEAPHVIDPNMQVWAGAISNGPSNYPLNASYKTADAYSFQDALGKSLEEICTIVPGGSLVFFPSYKLMEKLCMRWRETEQWSRLCLKKDLFVEPRGGAQDEFDSVLKGYYDSIRGKNKIIGRNRRAKKAGPIKTETQDDSKKGAAFLAVCRGKVSEGIDFADDNARAVIIVGIPFPNLHDIQVGLKKKYNDTYKSSKSLLGGSEWYCQQAYRALNQAAGRCIRHRFDYGAIIFLDERYKEQRNRASISKWLRQSIKVYDNFEASMEGLRSFFNSVKEQVDSKMLGSQEDSVEKNFSSEKQSKEFRRKENQIQNKSSQVEPKVEDYTNSNPKYHFMYESKAFGYHRDVKPKIAEDLRSMGHSAQTFVQVKEEAECCREVIDLECGVQPDLGYCEVSSVTNCDEAPETSFVQETSGMINGISVASPCSCSMNESSSPATVGLRSPGSPDQLLKQHISTPNFRKSPLGTESSVVATSERYSFGGTRSLTLEAESSFNMSVNSQALKRRKFTSSPVIDLEVENSDAPRPSTRPSDHTSLTRRIEFGFTEPRSQNYNIYSFPEVNQKVQLSCSLCRSPLGLPENHSYVNCLLTSSSKKYLLSLLKKTSRTGAAEMSTSVSIIMTDCSMVNQRLCRKFEGLKGQGIWCEQDGCVFNTIYCPFCSIPNTCLGVQVMATDSSNVQFLSKILFFADHLEVTNEAASKDSTLKHKEPLAETNAAVDKSDVLKSIDRFAYSPNQQQESGGWRTTKSKLRLPKRNLPTSKKA", "length": 1269, "header": "tr|A0A1P8AV25-1|A0A1P8AV25_ARATH Isoform 1 of RAD3-like DNA-binding helicase protein OS=Arabidopsis thaliana OX=3702 GN= PE=1 SV=1 CANONICAL=A0A1P8AV25-1" }, "isoforms": [ { "isoform_ac": "A0A1P8AV25-1", "url": "https://www.uniprot.org/uniprotkb/A0A1P8AV25/entry#A0A1P8AV25-1", "sequence": { "sequence": "MVSSTSKSDSKEEVKQTLNSKNPKNVYQIGGLQVEFPYQPYGTQLAFMSRVISTLDRAQRDGHCHALLESPTGTGKSLSLLCSVLAWQQNYKSRLLKGNLSHSKAAPEAATDPLNHGGGFIPETQPSDTPASTNVEKAETATKKRTKIPTIYYASRTHSQITQVIREYRKTGYRVPMAVLASRKHYCTNRHVLGKDNVDDECRLLLKDKANIQCSEFKNVNKITSHPSLQPRGHNEVHDIEDLVKVGKNVRGCPYFASWSMAENAQLVFCPYSYIVNPVIRAGVEVDLKGAIIIFDEAHNMEDIAREAGSINLEEDTLFKLQNELEQMSVAQPMIYQPLCEVVEGLISWIGRKKDSLAKRDFQHYFSSWTGDKALRELEESNITRECFPILLECFTKAIRTSKEAEMESDMLYLSGISVLTLEELFSSLTYFFSRNGSHILDYQLGLQRSTKRGDPSGTWTHTFSLWCMNPAVVFKDLADISLSVILTSGTLSPMNSFSSELGMQFGTSLEAPHVIDPNMQVWAGAISNGPSNYPLNASYKTADAYSFQDALGKSLEEICTIVPGGSLVFFPSYKLMEKLCMRWRETEQWSRLCLKKDLFVEPRGGAQDEFDSVLKGYYDSIRGKNKIIGRNRRAKKAGPIKTETQDDSKKGAAFLAVCRGKVSEGIDFADDNARAVIIVGIPFPNLHDIQVGLKKKYNDTYKSSKSLLGGSEWYCQQAYRALNQAAGRCIRHRFDYGAIIFLDERYKEQRNRASISKWLRQSIKVYDNFEASMEGLRSFFNSVKEQVDSKMLGSQEDSVEKNFSSEKQSKEFRRKENQIQNKSSQVEPKVEDYTNSNPKYHFMYESKAFGYHRDVKPKIAEDLRSMGHSAQTFVQVKEEAECCREVIDLECGVQPDLGYCEVSSVTNCDEAPETSFVQETSGMINGISVASPCSCSMNESSSPATVGLRSPGSPDQLLKQHISTPNFRKSPLGTESSVVATSERYSFGGTRSLTLEAESSFNMSVNSQALKRRKFTSSPVIDLEVENSDAPRPSTRPSDHTSLTRRIEFGFTEPRSQNYNIYSFPEVNQKVQLSCSLCRSPLGLPENHSYVNCLLTSSSKKYLLSLLKKTSRTGAAEMSTSVSIIMTDCSMVNQRLCRKFEGLKGQGIWCEQDGCVFNTIYCPFCSIPNTCLGVQVMATDSSNVQFLSKILFFADHLEVTNEAASKDSTLKHKEPLAETNAAVDKSDVLKSIDRFAYSPNQQQESGGWRTTKSKLRLPKRNLPTSKKA", "length": 1269, "header": "tr|A0A1P8AV25-1|A0A1P8AV25_ARATH Isoform 1 of RAD3-like DNA-binding helicase protein OS=Arabidopsis thaliana OX=3702 GN= PE=1 SV=1 CANONICAL=A0A1P8AV25-1" }, "locus": { "chromosome": "1", "start_pos": 7192794, "end_pos": 7185661, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "AT1G20720.2", "url": "https://www.ensemblgenomes.org/id/AT1G20720.2" }, { "database": "Ensembl Peptide", "id": "AT1G20720.2", "url": "https://www.ensemblgenomes.org/id/AT1G20720.2" } ] } }, { "isoform_ac": "F4HUN4-1", "url": "https://www.uniprot.org/uniprotkb/A0A1P8AV25/entry#F4HUN4-1", "sequence": { "sequence": "MVSSTSKSDSKEEVKQTLNSKNPKNVYQIGGLQVEFPYQPYGTQLAFMSRVISTLDRAQRDGHCHALLESPTGTGKSLSLLCSVLAWQQNYKSRLLKGNLSHSKAAPEAATDPLNHGGGFIPETQPSDTPASTNVEKAETATKKRTKIPTIYYASRTHSQITQVIREYRKTGYRVPMAVLASRKHYCTNRHVLGKDNVDDECRLLLKDKANIQCSEFKNVNKITSHPSLQPRGHNEVHDIEDLVKVGKNVRGCPYFASWSMAENAQLVFCPYSYIVNPVIRAGVEVDLKGAIIIFDEAHNMEDIAREAGSINLEEDTLFKLQNELEQMSVAQPMIYQPLCEVVEGLISWIGRKKDSLAKRDFQHYFSSWTGDKALRELEESNITRECFPILLECFTKAIRTSKEAEMESDMLYLSGISVLTLEELFSSLTYFFSRNGSHILDYQLGLQRSTKRGDPSGTWTHTFSLWCMNPAVVFKDLADISLSVILTSGTLSPMNSFSSELGMQFGTSLEAPHVIDPNMQVWAGAISNGPSNYPLNASYKTADAYSFQDALGKSLEEICTIVPGGSLVFFPSYKLMEKLCMRWRETEQWSRLCLKKDLFVEPRGGAQDEFDSVLKGYYDSIRGKNKIIGRNRRAKKAGPIKTETQDDSKKGAAFLAVCRGKVSEGIDFADDNARAVIIVGIPFPNLHDIQVGLKKKYNDTYKSSKSLLGGSEWYCQQAYRALNQAAGRCIRHRFDYGAIIFLDERYKEQRNRASISKWLRQSIKVYDNFEASMEGLRSFFNSVKEQVDSKMLGSQEDSVEKNFSSEKQSKEFRRKENQIQNKSSQVEPKVEDYTNSNPKYHFMYESKAFGYHRDVKPKIAEDLRSMGHSAQTFVQVKEEAECCREVIDLECGVQPDLGYCEVSSVTNCDEAPETSFVQETSGMINGISVASPCSCSMNESSSPATVGLRSPGSPDQLLKQHISTPNFRKSPLGTESSVVATSERYSFGGTRSLTLEAESSFNMSVNSQALKRRKFTSSPVIDLEVENSDAPRPNCSMVNQRLCRKFEGLKGQGIWCEQDGCVFNTIYCPFCSIPNTCLGVQVMATDSSNVQFLSKILFFADHLEVTNEAASKDSTLKHKEPLAETNAAVDKSDVLKSIDRFAYSPNQQQESGGWRTTKSKLRLPKRNLPTSKKA", "length": 1175, "header": "tr|F4HUN4-1|A0A1P8AV25_ARATH Computationally mapped isoform of RAD3-like DNA-binding helicase protein OS=Arabidopsis thaliana OX=3702 GN= PE=1 SV=1 CANONICAL=A0A1P8AV25-1" }, "locus": { "chromosome": "1", "start_pos": 7192794, "end_pos": 7185661, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "AT1G20720.1", "url": "https://www.ensemblgenomes.org/id/AT1G20720.1" }, { "database": "Ensembl Peptide", "id": "AT1G20720.1", "url": "https://www.ensemblgenomes.org/id/AT1G20720.1" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 5, "end_pos": 5, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "A0A1P8AV25", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A0A1P8AV25" }, { "database": "iPTMnet", "id": "F4HUN4", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/F4HUN4" } ], "site_lbl": "Thr5" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.", "journal": "Nature", "date": "2000", "authors": "Theologis A, Ecker J R, Palm C J, Federspiel N A, Kaul S, White O, Alonso J, Altafi H, Araujo R, Bowman C L, Brooks S Y, Buehler E, Chan A, Chao Q, Chen H, Cheuk R F, Chin C W, Chung M K, Conn L, Conway A B, Conway A R, Creasy T H, Dewar K, Dunn P, Etgu P, Feldblyum T V, Feng J, Fong B, Fujii C Y, Gill J E, Goldsmith A D, Haas B, Hansen N F, Hughes B, Huizar L, Hunter J L, Jenkins J, Johnson-Hopson C, Khan S, Khaykin E, Kim C J, Koo H L, Kremenetskaia I, Kurtz D B, Kwan A, Lam B, Langin-Hooper S, Lee A, Lee J M, Lenz C A, Li J H, Li Y, Lin X, Liu S X, Liu Z A, Luros J S, Maiti R, Marziali A, Militscher J, Miranda M, Nguyen M, Nierman W C, Osborne B I, Pai G, Peterson J, Pham P K, Rizzo M, Rooney T, Rowley D, Sakano H, Salzberg S L, Schwartz J R, Shinn P, Southwick A M, Sun H, Tallon L J, Tambunga G, Toriumi M J, Town C D, Utterback T, Van Aken S, Vaysberg M, Vysotskaia V S, Walker M, Wu D, Yu G, Fraser C M, Venter J C, Davis R W", "evidence": [ { "database": "UniProtKB", "id": "F4HUN4", "url": "https://www.uniprot.org/uniprot/F4HUN4" } ], "reference": [ { "type": "PubMed", "id": "11130712", "url": "https://glygen.org/publication/PubMed/11130712" } ] }, { "title": "Araport11: a complete reannotation of the Arabidopsis thaliana reference genome.", "journal": "Plant J.", "date": "2017", "authors": "Cheng Chia-Yi, Krishnakumar Vivek, Chan Agnes P, Thibaud-Nissen Fran\u00e7oise, Schobel Seth, Town Christopher D", "evidence": [ { "database": "UniProtKB", "id": "F4HUN4", "url": "https://www.uniprot.org/uniprot/F4HUN4" } ], "reference": [ { "type": "PubMed", "id": "27862469", "url": "https://glygen.org/publication/PubMed/27862469" } ] } ], "pathway": [ { "id": "ath:AT1G20720", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?ath:AT1G20720", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2K475-1", "protein_name": "BRCA1 interacting helicase 1", "gene_name": "Brip1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSSVLSEYTIGGVKIHFPCRAYPAQLAMMNSIVRGLNSSQHCLLESPTGSGKSLALLCSALAWQQSLTGKPVDEGLNKKPEAPSSCSCSCHSKNFTYSDTNLDTSPHFSSPSKPSSERNAVSSPCRDSPERNSLAAKLSAKKHASIHEDDDFQVEKKRIRPLETTQQIRKRHCLEKDVHHLDARLASEKRVKPESPIRKTSSSFQNPDGLCSRCCCSANQGINKESANTVKKDNGDQSKRPKIYFGTRTHKQIAQITRELRKTAYSGVPMTILSSRDHTCVHPEVVGNFNRNEKCMELLDGKHGKSCYFYHGVHRISNQQTLQFLHGISKAWDIEELVSLGRKLKACPYYTARELIDSADIIFCPYNYLLDSQIRESMDIKLKEQVVILDEAHNIEECARETASYSVTEVQLRFARDELDSLINSNIRKKSHEPLRDVCYNLINWLETNSKNLVERDYESSCKIWSGNEMLLNLHRMGITAASFPVLQKHLSAVLQKEEKVTSTHGKEEAIQIPIISASTQIMLKGLFMVLDYLFRKNSRFADDYKVAIQQTYSWTNQIAIFDKNALLPVPKNKKHSRQKIGVNVLNFWCLNPAVAFSDINDKVRTIVLTSGTLSPLKSFSSELGVTFNIQLEANHVISNSQVWVGTVGSGPKGRNLCATFQHTETFEFQDEVGMLLLSVCQTVSQGILCFLPSYKLLEKLRERWIFTGLWHSLESVKTVIAEPQGGEKTDFDELLQVYYDAIKFKGEKDGALLIAVCRGKVSEGLDFSDDNARAVITIGIPFPNVKDLQVELKRQYNDHHSKLRGLLPGRQWYEIQAYRALNQALGRCIRHKNDWGALILVDDRFNNNPDRYISGLSKWVRQQIQHHSTFASALESLTEFSKRHQKVTNRSKKEEKCTKENGSTLDVACLEGSTLTSVSEASHQTPENSLEEEAKVCVQEQRYPQMAAENPSGPSHGVSRRKESDPGLREKSVQTMKTEKSEISRSSSPTFGKQTEPVNWPIFNSLKRHFNSKVKNRTPVLKSSKNHASASSAFNKTALPLTGKCVSSSAPANTPLAPCPQSEVIIPSVKADTTPAKTHCKQNEKDPSPDAELSPVTEEAKGSSSNPAVGTEVDDDSVCFTPELFDPVSTDEENSELVETDRSSNNSDCLSAEELFETVTGFGQK", "length": 1166 }, "evidence": [ { "id": "A0A1P8AV25", "url": "https://omabrowser.org/oma/group/A0A1P8AV25/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1MMS0-1", "protein_name": "BRCA1 interacting helicase 1", "gene_name": "BRIP1", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MMSSAEYTIGGVKINFPCKAYPSQLAMMNSIVRGLNSKQHCLLESPTGSGKSLALLCSALAWQQSLSGKPVDESLSKKTEVPLSCCCTCHSKNSANSDVHQRTSHHFSSPSTPPSERNGTLSGSQDSPEKTTLAAKLSAKKQASMYRDENDDFQVEKKRIRPLETAQQIRKRHCFEKEVHHLDAKVASEKTTKLNSPLGKINSISPQNPPGHCSRCCCSTKQGNSEDSSNTTKKDHGGKFKIPKIYFGTRTHKQIAQITRELQRTAYSGVPMTILSSRDHTCVHPEVMGNFNRNEKCMELLDGKNGKSCYFYHGVHKMSDQHTLQTFQGMHKAWDIEELVSLGRKLKACPYYTARELMQNADIIFCPYNYLLDAQIRETMDINLKEQVVILDEAHNIEDCARESASYSVTEVQLRFARDELDSMINYNIRKKDHEPLRAVCCSLINWLEASSEHLVERNYESSCKVWSGSEMLLNLHKMGITTATFPILQGHFSAVLQREEKVPSIHGKEEAREIPVISASTQIMLKGLFMVLDYLFRQNSRFADDYKVAIQQTYSWINQSDTTDHGLLILSKNKKRLRQKAAVRVLNFWCLNPAVAFSDINGKVWAIVLTSGTLSPMKSFSSELGVTFTIQLEANHVINNSQVWVGTIGSGPKGRSLCATFQHTETFEFQDEVGALLLSVCQTISQGILCFLPSYKLLEKLKERWLSTGLWYNLELVKTVIVEPQGGEKIDFDELLQMYYDAIKYKGEKDGALLVAVCRGKVSEGLDFSDDNARAVVTIGIPFPNVKDLQVELKRQYNDQHSKLRGLLPGRQWYEIQAYRALNQALGRCIRHKNDWGALILVDDRFRSNPSRYISGLSKWVRQLIQHHSTFESALESLAEFAKKHQKVIAASKEDRKSIQGSEPTLGGACSKDSTYFLEAASHLSPEYAMEDDPELLEESAQAVGAEGIVISRSTSPTFSKQIDQVSWSGSNLGGQCLTGKILTGTPMVRSSEDCASTSSTFKTEKKCETVLLLTDKYESSSLTVDTSFGACPQSETIVPSTNVDAANLNSEDPAIQLSVVSEEAEPSPSNIASETEAEDESIYFTPELYDPVETNEEKNELVGTERDSRLTNSSNGILTEDLFEIKTTKGVDSVREMEAEDCTDTKLKRLMPIKESKVDDLGSNVKTTRK", "length": 1172 }, "evidence": [ { "id": "A0A1P8AV25", "url": "https://omabrowser.org/oma/group/A0A1P8AV25/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "Q54LI7-1", "protein_name": "DNA helicase", "gene_name": "BRIP1", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSSNNNNPPPKKVFSLSLLKPSPRVSGSSLPSSQSSQSSQSSQHSQSSQPPPSILSFFKAKPITSSSQSSQTPATTTTTTTTTTTTTKTSTTIGVKRPISDIMDSGDDFNYLENEPDDYYNTPFDYFNNSNINNNNNINNNNNNSVNKNTNTNSNINTNINGSIINNNNNKINVKDDASYEKYEELGNGVYKIGNYKVKFPFKPYACQASMMSRILEGLDSKENCILESPTGTGKTLSLLCSSLAWQEENKKKNQRDLEEKRKLALDSKQRMIEKKQLIDAAAAASAASNTTSNLPSITSTSTSNSTSTSTSTSPIKQEATATTATTNSISPIKQETTKTTTTMTTTPSTSPIKSEELNLDSYKYEKGLQCDYNGTGVGKFEPKKIPKIINKKPKYGSMTTTTTIQNNELIDYDNDGTQKFIKKKSPTIFFCSRTHSQIKQLTGELKKTPYRPNMVVLASRDQYCINPLLKDVPKKLEKCKKLLLDHGCRFKKTEQQTSLAKSSDFLGGGKKEVWDIEDLMEAGQAHSECPYFASRDMIEKADLIFCPYNYLIDPQIRKSFADKVAGSIVIFDEAHNIEDALMETSSFDSSLEELNEHCYQNFKDCIMNSRTMSMLSNEKALAIHYCYKLLESIIAWINKKVQTLKPIDFEKHQNVWKGEKILNIFEEFGLNETNYFSFRDHLATLFDEGDGTSDNGKEGGGGSLSFPSKGKGGIGVGSNKQKIDPVPQRALVLLESFEKVTAMIYQNKGWIEDYRLVLQKASAFQTNGGKKSNQGTKWNYQFGIWAMSPRIAFSSLVQATRSVVLTSGTLSPLYSFPMELAAKFPISAEMGNLPDIAQRAWIGTLSHGVKGTKLICTHGPSEGLDFQDSLGETILQHIELIPSGVLCFFPSYGFLEKLLSRWDETGILKKINAKKRYFYEPKNQREFIETLDNYREEIKQRPNKGAILFAVCRGKVSEGIDFSDEYARGVIVVGIPYPSLVDLRIVLKKEHNDTNKKGISGGDWYKLQAYRALNQALGRCIRHKNDYGSILLIDERFTQMGNWNSLSKWTRSCIKNNRNLNTSLSSLKLFYDSKNKQ", "length": 1078 }, "evidence": [ { "id": "A0A1P8AV25", "url": "https://omabrowser.org/oma/group/A0A1P8AV25/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q5SXJ3-1", "protein_name": "Fanconi anemia group J protein homolog", "gene_name": "Brip1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSSVLSDYTIGGVKIHFPCRAYPAQLAMMNSIVRGLNSSQHCLLESPTGSGKSLALLCSALAWQQSLSEKPVDEGLNKKPEAPPSCSCACHSKNFTYSDTNLDTSPHFNSPSKPSSGRNGVSTPCQDSPEKNTLAAKLSAKKQASIHRDEDDDFQVEKKRIRPLETTQQIRKRHCLEKDVHHVDARLASEKRVKPESPIGKSFSDRKDSFQNVDGLCSRCCCSAKQGNNQEPANTVKKDHGGQCKRPKIYFGTRTHKQIAQITRELRKTAYSGVPMTILSSRDHSCVHPEVVGNFNRKEKCMELLDGKHGKSCYFYHGVHKISNQQTLQHLQGMSRAWDIEELVSLGRKLKACPYYTARELIEDADIVFCPYNYLLDSQIRETMDIKLKGQVVILDEAHNIEDCARESASYSVTEVQLRFARDELDSLINGNIRKKSHEPLRDVCYNLINWLETNSKHLVERGYESSCKIWSGNEMLLNLYRMGITTATFPVLQRHLSAVLQKEEKVTPIHGKEEAIQIPIISASTQVVLKGLFMVLDYLFRENSRFADDYKVAIQQTYSWTNQIAIFDKTGVLAVPKNKKHSRQKIGVNALNFWCLNPAVAFSDINDKVRTIVLTSGTLSPLKSFSSELGVTFSIQLEANHVISNSQVWVGTVGSGPKGRNLCATFQHTETFEFQDEVGMLLLSVCQTVSQGILCFLPSYKLLEKLRERWIFTGLWHSLESVKTVIAEPQGGEKTDFDELLQVYYDAIKFKGEKDGALLIAVCRGKVSEGLDFSDDNARAVITVGIPFPNVKDLQVELKRQYNDHHSKSRGLLPGRQWYEIQAYRALNQALGRCIRHKNDWGALILVDDRFNNNPNRYISGLSKWVRQQIQHHSSFASALESLTEFSRRHQKVTNRSKKDEKCTKDNEPTLEVACLEDSTFTSVSESSHQSPENSTEEAEVCVQELQCPQVATKSPSVASHGVSRRKKSDPGLRGESLQTMKTEKNEISRSSSPTFGKQTEPVNWPIFNSLRRHFNSKVKNCTPVLKSSKNRAPGSSTFNKTALPLTGNCVPSNETADTSLGPCLQSEVIISPVKIEATPATNYSKQVFCCEKDLLPDTELSPGTEEAKCPSSNKAAETEVDDDSECFTPELFDPVDTNEENGELVETDRSSHSSDCFSAEELFETATGFGQK", "length": 1174 }, "evidence": [ { "id": "A0A1P8AV25", "url": "https://omabrowser.org/oma/group/A0A1P8AV25/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9BX63-1", "protein_name": "Fanconi anemia group J protein", "gene_name": "BRIP1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSSMWSEYTIGGVKIYFPYKAYPSQLAMMNSILRGLNSKQHCLLESPTGSGKSLALLCSALAWQQSLSGKPADEGVSEKAEVQLSCCCACHSKDFTNNDMNQGTSRHFNYPSTPPSERNGTSSTCQDSPEKTTLAAKLSAKKQASIYRDENDDFQVEKKRIRPLETTQQIRKRHCFGTEVHNLDAKVDSGKTVKLNSPLEKINSFSPQKPPGHCSRCCCSTKQGNSQESSNTIKKDHTGKSKIPKIYFGTRTHKQIAQITRELRRTAYSGVPMTILSSRDHTCVHPEVVGNFNRNEKCMELLDGKNGKSCYFYHGVHKISDQHTLQTFQGMCKAWDIEELVSLGKKLKACPYYTARELIQDADIIFCPYNYLLDAQIRESMDLNLKEQVVILDEAHNIEDCARESASYSVTEVQLRFARDELDSMVNNNIRKKDHEPLRAVCCSLINWLEANAEYLVERDYESACKIWSGNEMLLTLHKMGITTATFPILQGHFSAVLQKEEKISPIYGKEEAREVPVISASTQIMLKGLFMVLDYLFRQNSRFADDYKIAIQQTYSWTNQIDISDKNGLLVLPKNKKRSRQKTAVHVLNFWCLNPAVAFSDINGKVQTIVLTSGTLSPMKSFSSELGVTFTIQLEANHIIKNSQVWVGTIGSGPKGRNLCATFQNTETFEFQDEVGALLLSVCQTVSQGILCFLPSYKLLEKLKERWLSTGLWHNLELVKTVIVEPQGGEKTNFDELLQVYYDAIKYKGEKDGALLVAVCRGKVSEGLDFSDDNARAVITIGIPFPNVKDLQVELKRQYNDHHSKLRGLLPGRQWYEIQAYRALNQALGRCIRHRNDWGALILVDDRFRNNPSRYISGLSKWVRQQIQHHSTFESALESLAEFSKKHQKVLNVSIKDRTNIQDNESTLEVTSLKYSTSPYLLEAASHLSPENFVEDEAKICVQELQCPKIITKNSPLPSSIISRKEKNDPVFLEEAGKAEKIVISRSTSPTFNKQTKRVSWSSFNSLGQYFTGKIPKATPELGSSENSASSPPRFKTEKMESKTVLPFTDKCESSNLTVNTSFGSCPQSETIISSLKIDATLTRKNHSEHPLCSEEALDPDIELSLVSEEDKQSTSNRDFETEAEDESIYFTPELYDPEDTDEEKNDLAETDRGNRLANNSDCILAKDLFEIRTIKEVDSAREVKAEDCIDTKLNGILHIEESKIDDIDGNVKTTWINELELGKTHEIEIKNFKPSPSKNKGMFPGFK", "length": 1249 }, "evidence": [ { "id": "A0A1P8AV25", "url": "https://omabrowser.org/oma/group/A0A1P8AV25/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0A1P8AV25", "url": "https://www.uniprot.org/uniprot/A0A1P8AV25" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0A1P8AV25", "url": "https://www.uniprot.org/uniprot/A0A1P8AV25" } ], "pmid": "" }, { "name": "DNA helicase activity", "id": "GO:0003678", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003678", "evidence": [ { "database": "UniProtKB", "id": "A0A1P8AV25", "url": "https://www.uniprot.org/uniprot/A0A1P8AV25" } ], "pmid": "" }, { "name": "hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides", "id": "GO:0016818", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016818", "evidence": [ { "database": "UniProtKB", "id": "A0A1P8AV25", "url": "https://www.uniprot.org/uniprot/A0A1P8AV25" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0A1P8AV25", "url": "https://www.uniprot.org/uniprot/A0A1P8AV25" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A1P8AV25", "url": "https://www.uniprot.org/uniprot/A0A1P8AV25" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA repair", "id": "GO:0006281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006281", "evidence": [ { "database": "UniProtKB", "id": "A0A1P8AV25", "url": "https://www.uniprot.org/uniprot/A0A1P8AV25" } ], "pmid": "" }, { "name": "double-strand break repair involved in meiotic recombination", "id": "GO:1990918", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990918", "evidence": [ { "database": "UniProtKB", "id": "A0A1P8AV25", "url": "https://www.uniprot.org/uniprot/A0A1P8AV25" } ], "pmid": "" }, { "name": "nucleotide-excision repair", "id": "GO:0006289", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006289", "evidence": [ { "database": "UniProtKB", "id": "A0A1P8AV25", "url": "https://www.uniprot.org/uniprot/A0A1P8AV25" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1003, "end_pos": 1005, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1088, "end_pos": 1090, "annotation": "n_glycosylation_sequon" }, { "start_pos": 382, "end_pos": 384, "annotation": "n_glycosylation_sequon" }, { "start_pos": 436, "end_pos": 438, "annotation": "n_glycosylation_sequon" }, { "start_pos": 537, "end_pos": 539, "annotation": "n_glycosylation_sequon" }, { "start_pos": 699, "end_pos": 701, "annotation": "n_glycosylation_sequon" }, { "start_pos": 803, "end_pos": 805, "annotation": "n_glycosylation_sequon" }, { "start_pos": 822, "end_pos": 824, "annotation": "n_glycosylation_sequon" }, { "start_pos": 939, "end_pos": 941, "annotation": "n_glycosylation_sequon" }, { "start_pos": 99, "end_pos": 101, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A1P8AV25-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1269, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A1P8AV25-F1.pdb" } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 5 ], "sequon_annotation_sites": [ { "start_pos": 1003, "end_pos": 1005 }, { "start_pos": 1088, "end_pos": 1090 }, { "start_pos": 382, "end_pos": 384 }, { "start_pos": 436, "end_pos": 438 }, { "start_pos": 537, "end_pos": 539 }, { "start_pos": 699, "end_pos": 701 }, { "start_pos": 803, "end_pos": 805 }, { "start_pos": 822, "end_pos": 824 }, { "start_pos": 939, "end_pos": 941 }, { "start_pos": 99, "end_pos": 101 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }