{ "uniprot_canonical_ac": "A0A1L2C162-1", "uniprot_ac": "A0A1L2C162", "uniprot_id": "A0A1L2C162_RAT", "mass": { "chemical_mass": 28928.0, "monoisotopic_mass": 28928.0 }, "refseq": { "ac": "NP_001102381", "name": "uroplakin-1a", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102381" }, "gene_names": [ { "name": "Upk1a", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A1L2C162", "id": "A0A1L2C162" }, { "name": "Upk1a", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102381", "id": "NP_001102381" } ], "protein_names": [ { "name": "Tetraspanin", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A1L2C162/entry#names_and_taxonomy", "id": "A0A1L2C162" }, { "name": "uroplakin-1a", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102381", "id": "NP_001102381" } ], "function": [ { "annotation": "During urothelial carcinogenesis, UPII expression was the most decreased in all urothelial lesions, while UPIa, UPIb, and UPIIIa expression was differently altered in different types of lesions", "evidence": [ { "database": "RefSeq", "id": "NP_001102381", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102381" }, { "database": "PubMed", "id": "21301865", "url": "https://glygen.org/publication/PubMed/21301865" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A1L2C162", "url": "https://www.uniprot.org/uniprot/A0A1L2C162" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "gene": [ { "name": "Upk1a", "url": "https://www.uniprot.org/uniprot/A0A1L2C162", "locus": { "chromosome": "1", "start_pos": 85859671, "end_pos": 85870354, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000024331", "url": "https://www.ensembl.org/id/ENSRNOG00000024331" } ] } } ], "crossref": [ { "id": "ENSRNOG00000024331", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000024331", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd03156", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03156", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "365227", "url": "https://www.ncbi.nlm.nih.gov/gene/365227", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000301", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000301", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008952", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008952", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018499", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018499", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:365227", "url": "https://www.genome.jp/dbget-bin/www_bget?rno:365227", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "VVYIFEC", "url": "https://omabrowser.org/oma/group/VVYIFEC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A1L2C162", "url": "https://www.orthodb.org/?gene=A0A1L2C162", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "D3ZDW5", "url": "https://www.orthodb.org/?gene=D3ZDW5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19282", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19282", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19282:SF25", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19282:SF25", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00335", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00335", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "NP_001102381", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102381", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "1309849", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1309849", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "A0A1L2C162", "url": "https://www.uniprot.org/uniprot/A0A1L2C162", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1L2C162-1", "url": "https://www.uniprot.org/uniprot/A0A1L2C162-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5ZVR2", "url": "https://www.uniprot.org/uniprot/A0A8I5ZVR2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5ZVR2-1", "url": "https://www.uniprot.org/uniprot/A0A8I5ZVR2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3ZDW5", "url": "https://www.uniprot.org/uniprot/D3ZDW5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3ZDW5-1", "url": "https://www.uniprot.org/uniprot/D3ZDW5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASTATEGEKGSPVVVGLLVVGNIIILLSGLALFAETVWVTADQYRVYPLMGVSGKDDVFAGAWIAIFCGFSFFVVASFGVGAALCRRRYMILTYLLLMLIVYIFECASCITSYTHRDYMVSNPSLITKQMLTFYSADTDQGQELTRLWDRIMIEQECCGTSGPMDWVNYTSAFRAATPEVVFPWPPLCCRRTGNFIPINEDGCRVGHMDYLFTKGCFEHISHAIDSYTWGISWFGFAILMWTLPVMMIAMYFYTIL", "length": 257, "header": "tr|A0A1L2C162-1|A0A1L2C162_RAT Isoform 1 of Tetraspanin OS=Rattus norvegicus OX=10116 GN=Upk1a PE=2 SV=1 CANONICAL=A0A1L2C162-1" }, "isoforms": [ { "isoform_ac": "A0A1L2C162-1", "url": "https://www.uniprot.org/uniprotkb/A0A1L2C162/entry#A0A1L2C162-1", "sequence": { "sequence": "MASTATEGEKGSPVVVGLLVVGNIIILLSGLALFAETVWVTADQYRVYPLMGVSGKDDVFAGAWIAIFCGFSFFVVASFGVGAALCRRRYMILTYLLLMLIVYIFECASCITSYTHRDYMVSNPSLITKQMLTFYSADTDQGQELTRLWDRIMIEQECCGTSGPMDWVNYTSAFRAATPEVVFPWPPLCCRRTGNFIPINEDGCRVGHMDYLFTKGCFEHISHAIDSYTWGISWFGFAILMWTLPVMMIAMYFYTIL", "length": 257, "header": "tr|A0A1L2C162-1|A0A1L2C162_RAT Isoform 1 of Tetraspanin OS=Rattus norvegicus OX=10116 GN=Upk1a PE=2 SV=1 CANONICAL=A0A1L2C162-1" }, "locus": { "chromosome": "1", "start_pos": 85870140, "end_pos": 85860185, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000105462.1", "url": "https://www.ensembl.org/id/ENSRNOT00000105462.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000097413.1", "url": "https://www.ensembl.org/id/ENSRNOP00000097413.1" } ] } }, { "isoform_ac": "A0A8I5ZVR2-1", "url": "https://www.uniprot.org/uniprotkb/A0A1L2C162/entry#A0A8I5ZVR2-1", "sequence": { "sequence": "MASTATEGEKGSPVVVGLLVVGNIIILLSGLALFAETVWVTADQYRVYPLMGVSGKDDVFAGAWIAIFCGFSFFVVASFGVGAALCRRRYMILTMVSNPSLITKQMLTFYSADTDQGQELTRLWDRIMIEQECCGTSGPMDWVNYTSAFRAATPEVVFPWPPLCCRRTGNFIPINEDGCRVGHMDYLFTKGCFEHISHAIDSYTWGISWFGFAILMWTLPVMMIAMYFYTIL", "length": 232, "header": "tr|A0A8I5ZVR2-1|A0A1L2C162_RAT Computationally mapped isoform of Tetraspanin OS=Rattus norvegicus OX=10116 GN=Upk1a PE=2 SV=1 CANONICAL=A0A1L2C162-1" }, "locus": { "chromosome": "1", "start_pos": 85870140, "end_pos": 85860185, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000115298.1", "url": "https://www.ensembl.org/id/ENSRNOT00000115298.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000083363.1", "url": "https://www.ensembl.org/id/ENSRNOP00000083363.1" } ] } }, { "isoform_ac": "D3ZDW5-1", "url": "https://www.uniprot.org/uniprotkb/A0A1L2C162/entry#D3ZDW5-1", "sequence": { "sequence": "EQMTRFLLLVVGGGLSGLALFAETVWVTADQYRVYPLMGVSGKDDVFAGAWIAIFCGFSFFVVASFGVGAALCRRRYMILTYLLLMLIVYIFECASCITSYTHRDYMVSNPSLITKQMLTFYSADTDQGQELTRLWDRIMIEQECCGTSGPMDWVNYTSAFRAATPEVVFPWPPLCCRRTGNFIPINEDGCRVGHMDYLFTKGCFEHISHAIDSYTWGISWFGFAILMWTLPVMMIAMYFYTIL", "length": 244, "header": "tr|D3ZDW5-1|A0A1L2C162_RAT Computationally mapped isoform of Tetraspanin OS=Rattus norvegicus OX=10116 GN=Upk1a PE=2 SV=3 CANONICAL=A0A1L2C162-1" }, "locus": { "chromosome": "1", "start_pos": 85868530, "end_pos": 85860185, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000033621.5", "url": "https://www.ensembl.org/id/ENSRNOT00000033621.5" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000036268.5", "url": "https://www.ensembl.org/id/ENSRNOP00000036268.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Altered expression of UPIa, UPIb, UPII, and UPIIIa during urothelial carcinogenesis induced by N-butyl-N-(4-hydroxybutyl)nitrosamine in rats.", "journal": "Virchows Archiv : an international journal of pathology", "date": "2011", "authors": "Zupancic D, Ovcak Z, Vidmar G, Romih R", "evidence": [ { "database": "RefSeq", "id": "NP_001102381", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102381" } ], "reference": [ { "type": "PubMed", "id": "21301865", "url": "https://glygen.org/publication/PubMed/21301865" } ] } ], "pathway": [ { "id": "rno:365227", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?rno:365227", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0AAA9TIE2-1", "protein_name": "Uroplakin 1A", "gene_name": "UPK1A", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MPSLFLAHSSPRLLVEHSSQNLVTHTHLPNSPSVPEGSIPSTCLVSSLLPASSSGPGRPGSLPWRGGANQPRRQFWDSGLACGFHLNLSPSQGGSSPAERSRVVYSPSLPCPHPHPHKGLRTRGHRMSPCPCGQHNLEFQVYKSLAGGGVGEGGHKAVLPYWSARLTSCPLLQTPSPLQETGLRRGLGVYREPLWEGLAREATGREGRTMASAAAATTEKGSPVVVGLLVVGNIIILLSGLALFAETVWVTADQYRMYPLMGVSGKDDVFAGAWIAIFCGFSFFVVASFGVGAALCRRRSMILTYLILMLIIYIFECASCITSYTHRDYMVSNPSLITKQMLTFYSADSNQGRELTRLWDRIMIEQECCGTSGPMDWVNFTSAFRATTPEVVFPWPPLCCRRTGNFIPVNEEGCRLGHLDYLFTKGCFEHIGHAIDSYTWGISWFGFAILMWTLPVMLIAMYFYTTL", "length": 467 }, "evidence": [ { "id": "A0A1L2C162", "url": "https://omabrowser.org/oma/group/A0A1L2C162/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "O00322-1", "protein_name": "Uroplakin-1a", "gene_name": "UPK1A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASAAAAEAEKGSPVVVGLLVVGNIIILLSGLSLFAETIWVTADQYRVYPLMGVSGKDDVFAGAWIAIFCGFSFFMVASFGVGAALCRRRSMVLTYLVLMLIVYIFECASCITSYTHRDYMVSNPSLITKQMLTFYSADTDQGQELTRLWDRVMIEQECCGTSGPMDWVNFTSAFRAATPEVVFPWPPLCCRRTGNFIPLNEEGCRLGHMDYLFTKGCFEHIGHAIDSYTWGISWFGFAILMWTLPVMLIAMYFYTML", "length": 258 }, "evidence": [ { "id": "A0A1L2C162", "url": "https://omabrowser.org/oma/group/A0A1L2C162/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q06AT5-1", "protein_name": "Tetraspanin", "gene_name": "UPK1A", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MASAAAEGEKGSPVVVGLLVVGNIIILLSGLALFAETIWVTADQYRVYPLMGVSGKDDVFAGAWIAIFCGFSFFVVASFGVGAALCRRRSMILTYLVLMLIVYIFECASCITSYTHRDYMVSNPSLITKQMLTFYSADSDQGRELTRLWDRVMIEQECCGTSGPMDWVNFTSAFRASTPEVVFPWPPLCCRRTGNFIPVNEEGCRLGHLDYLFTKGCFEHIGHAIDSYTWGISWFGFAILMWTLPVMLIAMYFYTTL", "length": 257 }, "evidence": [ { "id": "A0A1L2C162", "url": "https://omabrowser.org/oma/group/A0A1L2C162/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q9D132-1", "protein_name": "Uroplakin-1a", "gene_name": "Upk1a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASAATEGEKGSPVVVGLLVVGNIIILLSGLALFAETVWVTADQYRVYPLMGVSGKDDVFAGAWIAIFCGFSFFVVASFGVGAALCRRRYMILTYLLLMLIVYIFECASCITSYTHRDYMVSNPSLITKQMLTYYSADTDQGQELTRLWDRIMIEQECCGTSGPMDWVNYTSAFRAATPEVVFPWPPLCCRRTGNFIPINEDGCRVGHMDYLFTKGCFEHIGHAIDSYTWGISWFGFAILMWTLPVMLIAMYFYTTL", "length": 257 }, "evidence": [ { "id": "A0A1L2C162", "url": "https://omabrowser.org/oma/group/A0A1L2C162/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "apical plasma membrane urothelial plaque", "id": "GO:0120001", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120001", "evidence": [ { "database": "UniProtKB", "id": "A0A1L2C162", "url": "https://www.uniprot.org/uniprot/A0A1L2C162" } ], "pmid": "" }, { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "A0A1L2C162", "url": "https://www.uniprot.org/uniprot/A0A1L2C162" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0A1L2C162", "url": "https://www.uniprot.org/uniprot/A0A1L2C162" } ], "pmid": "" }, { "name": "apical plasma membrane", "id": "GO:0016324", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016324", "evidence": [ { "database": "UniProtKB", "id": "A0A1L2C162", "url": "https://www.uniprot.org/uniprot/A0A1L2C162" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "epithelial cell differentiation", "id": "GO:0030855", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030855", "evidence": [ { "database": "UniProtKB", "id": "A0A1L2C162", "url": "https://www.uniprot.org/uniprot/A0A1L2C162" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 169, "end_pos": 171, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 169, "end_pos": 171 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": 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