{ "uniprot_canonical_ac": "A0A1L1RNA9-1", "uniprot_ac": "A0A1L1RNA9", "uniprot_id": "A0A1L1RNA9_CHICK", "mass": { "chemical_mass": 37021.0, "monoisotopic_mass": 37021.0 }, "refseq": {}, "gene_names": [ { "name": "TMX2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A1L1RNA9", "id": "A0A1L1RNA9" } ], "protein_names": [ { "name": "Thioredoxin related transmembrane protein 2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A1L1RNA9/entry#names_and_taxonomy", "id": "A0A1L1RNA9" } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Gallus gallus", "taxid": 9031, "evidence": [ { "database": "UniProtKB", "id": "A0A1L1RNA9", "url": "https://www.uniprot.org/uniprot/A0A1L1RNA9" } ], "common_name": "Chicken", "glygen_name": "Chicken", "reference_species": "Gallus gallus [9031]" } ], "gene": [ { "name": "TMX2", "url": "https://www.uniprot.org/uniprot/A0A1L1RNA9", "locus": { "chromosome": "5", "start_pos": 16531228, "end_pos": 16533624, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSGALG00010026203", "url": "https://www.ensembl.org/id/ENSGALG00010026203" } ] } } ], "crossref": [ { "id": "A0A1L1RNA9", "url": "https://alphafold.ebi.ac.uk/entry/A0A1L1RNA9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSGALG00000007350", "url": "https://bgee.org/?page=gene&gene_id=ENSGALG00000007350", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02962", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02962", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR013766", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013766", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036249", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036249", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037463", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037463", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039101", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039101", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "KIDIGRW", "url": "https://omabrowser.org/oma/group/KIDIGRW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A1L1RNA9", "url": "https://www.orthodb.org/?gene=A0A1L1RNA9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15853", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15853", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15853:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15853:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00085", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00085", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "A0A1L1RNA9", "url": "https://www.uniprot.org/uniprot/A0A1L1RNA9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1L1RNA9-1", "url": "https://www.uniprot.org/uniprot/A0A1L1RNA9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V1ACX3", "url": "https://www.uniprot.org/uniprot/A0A8V1ACX3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V1ACX3-1", "url": "https://www.uniprot.org/uniprot/A0A8V1ACX3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1C8J7", "url": "https://www.uniprot.org/uniprot/E1C8J7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1C8J7-1", "url": "https://www.uniprot.org/uniprot/E1C8J7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAVLAPLLALLYSVPGLCRWLARPYYPLSALLATAFLLVRKVPPLCRGLPSQREDGNPCDFDWREVEILMFLSAIVMMKNRRSITVEQHIGNIFMFSKVANAILFFRLDIRMGLLYLTLCIVFLMTCKPPLYMGPEYIKYFSDKTIDEELERDKRVTWIVEFFANWSSECQSFAPIFADLSLKYNCSGLHFGKVDVGRYTDVSTRSVGPRERVGGGTRPSKCLGVIVCLLPYSCRYKVSTSPLTKQLPTLILFQGGTEIMRRPQIDKKGRAVSWTFSEENVIREFNLNELYQKAKKQSKPRDEGSEEPPEGQAAAGLANGETKKEK", "length": 326, "header": "tr|A0A1L1RNA9-1|A0A1L1RNA9_CHICK Isoform 1 of Thioredoxin related transmembrane protein 2 OS=Gallus gallus OX=9031 GN=TMX2 PE=1 SV=2 CANONICAL=A0A1L1RNA9-1" }, "isoforms": [ { "isoform_ac": "A0A1L1RNA9-1", "url": "https://www.uniprot.org/uniprotkb/A0A1L1RNA9/entry#A0A1L1RNA9-1", "sequence": { "sequence": "MAVLAPLLALLYSVPGLCRWLARPYYPLSALLATAFLLVRKVPPLCRGLPSQREDGNPCDFDWREVEILMFLSAIVMMKNRRSITVEQHIGNIFMFSKVANAILFFRLDIRMGLLYLTLCIVFLMTCKPPLYMGPEYIKYFSDKTIDEELERDKRVTWIVEFFANWSSECQSFAPIFADLSLKYNCSGLHFGKVDVGRYTDVSTRSVGPRERVGGGTRPSKCLGVIVCLLPYSCRYKVSTSPLTKQLPTLILFQGGTEIMRRPQIDKKGRAVSWTFSEENVIREFNLNELYQKAKKQSKPRDEGSEEPPEGQAAAGLANGETKKEK", "length": 326, "header": "tr|A0A1L1RNA9-1|A0A1L1RNA9_CHICK Isoform 1 of Thioredoxin related transmembrane protein 2 OS=Gallus gallus OX=9031 GN=TMX2 PE=1 SV=2 CANONICAL=A0A1L1RNA9-1" }, "locus": { "chromosome": "5", "start_pos": 16533511, "end_pos": 16531469, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSGALT00010063779.1", "url": "https://www.ensembl.org/id/ENSGALT00010063779.1" }, { "database": "Ensembl Peptide", "id": "ENSGALP00010039334.1", "url": "https://www.ensembl.org/id/ENSGALP00010039334.1" } ] } }, { "isoform_ac": "A0A8V1ACX3-1", "url": "https://www.uniprot.org/uniprotkb/A0A1L1RNA9/entry#A0A8V1ACX3-1", "sequence": { "sequence": "MAVLAPLLALLYSVPGLCRWLARPYYPLSALLATAFLLVRKVPPLCRGLPSQREDGNPCDFDWREVEILMFLSAIVMMKNRRSITVEQHIGNIFMFSKVANAILFFRLDIRMGLLYLTLCIVFLMTCKPPLYMGPEYIKYFSDKTIDEELERDKRVTWIVEFFANWSSECQSFAPIFADLSLKYNCSGLHFGKVDVGRYTDVSTRYKIDKKGRAVSWTFSEENVIREFNLNELYQKAKKQSKPRDEGSEEPPEGQAAAGLANGETKKEK", "length": 269, "header": "tr|A0A8V1ACX3-1|A0A1L1RNA9_CHICK Computationally mapped isoform of Thioredoxin related transmembrane protein 2 OS=Gallus gallus OX=9031 GN=TMX2 PE=1 SV=1 CANONICAL=A0A1L1RNA9-1" }, "locus": { "chromosome": "5", "start_pos": 16533511, "end_pos": 16531469, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSGALT00010063787.1", "url": "https://www.ensembl.org/id/ENSGALT00010063787.1" }, { "database": "Ensembl Peptide", "id": "ENSGALP00010039336.1", "url": "https://www.ensembl.org/id/ENSGALP00010039336.1" } ] } }, { "isoform_ac": "E1C8J7-1", "url": "https://www.uniprot.org/uniprotkb/A0A1L1RNA9/entry#E1C8J7-1", "sequence": { "sequence": "MAVLAPLLALLYSVPGLCRWLARPYYPLSALLATAFLLVRKVPPLCRGLPSQREDGNPCDFDWREVEILMFLSAIVMMKNRRSITVEQHIGNIFMFSKVANAILFFRLDIRMGLLYLTLCIVFLMTCKPPLYMGPEYIKYFSDKTIDEELERDKRVTWIVEFFANWSSECQSFAPIFADLSLKYNCSGLHFGKVDVGRYTDVSTRYKVSTSPLTKQLPTLILFQGGTEIMRRPQIDKKGRAVSWTFSEENVIREFNLNELYQKAKKQSKPRDEGSEEPPEGQAAAGLANGETKKEK", "length": 296, "header": "tr|E1C8J7-1|A0A1L1RNA9_CHICK Computationally mapped isoform of Thioredoxin related transmembrane protein 2 OS=Gallus gallus OX=9031 GN=TMX2 PE=1 SV=1 CANONICAL=A0A1L1RNA9-1" }, "locus": { "chromosome": "5", "start_pos": 16533511, "end_pos": 16531469, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSGALT00010063783.1", "url": "https://www.ensembl.org/id/ENSGALT00010063783.1" }, { "database": "Ensembl Peptide", "id": "ENSGALP00010039335.1", "url": "https://www.ensembl.org/id/ENSGALP00010039335.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "Q2TBU2-1", "protein_name": "Thioredoxin-related transmembrane protein 2", "gene_name": "TMX2", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MAVLAPLIALVYSVPRLSRWLARPYYFLSALLSAAFLLVRKLPPVCESLPTQREDGNPCDFDWREVEILMFLSAIVMMKNRRSITVEQHVGNIFMFSKVANAILFFRLDIRMGLLYITLCIVFLMTCKPPLYMGPEYIKYFSDKTIDEELERDKRVTWIVEFFANWSSDCQSFAPIYADLSLKYNCTGLNFGKVDVGRYTDVSTRYKVSTSPLTKQLPTLILFQGGKEVMRRPQIDKKGRAVSWTFSEENVIREFNLNELYQRAKKLSKAGDKIPEEQPVAAVPAAVPDEESKKDK", "length": 296 }, "evidence": [ { "id": "A0A1L1RNA9", "url": "https://omabrowser.org/oma/group/A0A1L1RNA9/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "disulfide oxidoreductase activity", "id": "GO:0015036", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015036", "evidence": [ { "database": "UniProtKB", "id": "A0A1L1RNA9", "url": "https://www.uniprot.org/uniprot/A0A1L1RNA9" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0A1L1RNA9", "url": "https://www.uniprot.org/uniprot/A0A1L1RNA9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "mitochondrial membrane", "id": "GO:0031966", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031966", "evidence": [ { "database": "UniProtKB", "id": "A0A1L1RNA9", "url": "https://www.uniprot.org/uniprot/A0A1L1RNA9" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "A0A1L1RNA9", "url": "https://www.uniprot.org/uniprot/A0A1L1RNA9" } ], "pmid": "" }, { "name": "mitochondria-associated endoplasmic reticulum membrane contact site", "id": "GO:0044233", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044233", "evidence": [ { "database": "UniProtKB", "id": "A0A1L1RNA9", "url": "https://www.uniprot.org/uniprot/A0A1L1RNA9" } ], "pmid": "" }, { "name": "membrane-bounded organelle", "id": "GO:0043227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043227", "evidence": [ { "database": "UniProtKB", "id": "A0A1L1RNA9", "url": "https://www.uniprot.org/uniprot/A0A1L1RNA9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "brain development", "id": "GO:0007420", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007420", "evidence": [ { "database": "UniProtKB", "id": "A0A1L1RNA9", "url": "https://www.uniprot.org/uniprot/A0A1L1RNA9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 165, "end_pos": 167, "annotation": "n_glycosylation_sequon" }, { "start_pos": 185, "end_pos": 187, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A1L1RNA9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 326, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": 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