{ "uniprot_canonical_ac": "A0A1L1RLE3-1", "uniprot_ac": "A0A1L1RLE3", "uniprot_id": "A0A1L1RLE3_CHICK", "mass": { "chemical_mass": 37318.0, "monoisotopic_mass": 37318.0 }, "refseq": {}, "gene_names": [ { "name": "C12orf29", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A1L1RLE3", "id": "A0A1L1RLE3" } ], "protein_names": [ { "name": "RNA ligase 1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A1L1RLE3/entry#names_and_taxonomy", "id": "A0A1L1RLE3" }, { "name": "6.5.1.3", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A1L1RLE3/entry#names_and_taxonomy", "id": "A0A1L1RLE3" }, { "name": "RNA ligase", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A1L1RLE3/entry#names_and_taxonomy", "id": "A0A1L1RLE3" } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Gallus gallus", "taxid": 9031, "evidence": [ { "database": "UniProtKB", "id": "A0A1L1RLE3", "url": "https://www.uniprot.org/uniprot/A0A1L1RLE3" } ], "common_name": "Chicken", "glygen_name": "Chicken", "reference_species": "Gallus gallus [9031]" } ], "gene": [ { "name": "C12orf29", "url": "https://www.uniprot.org/uniprot/A0A1L1RLE3", "locus": { "chromosome": "1", "start_pos": 42855676, "end_pos": 42849506, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSGALG00010011381", "url": "https://www.ensembl.org/id/ENSGALG00010011381" } ] } } ], "crossref": [ { "id": "A0A1L1RLE3", "url": "https://alphafold.ebi.ac.uk/entry/A0A1L1RLE3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSGALG00000011168", "url": "https://bgee.org/?page=gene&gene_id=ENSGALG00000011168", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR041211", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041211", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "GTCCYVS", "url": "https://omabrowser.org/oma/group/GTCCYVS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A1L1RLE3", "url": "https://www.orthodb.org/?gene=A0A1L1RLE3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31219", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31219", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31219:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31219:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF17720", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17720", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "XP_015139070", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015139070", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A1L1RLE3", "url": "https://www.uniprot.org/uniprot/A0A1L1RLE3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1L1RLE3-1", "url": "https://www.uniprot.org/uniprot/A0A1L1RLE3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSRRGAVQRKVPCLFVTEVKEEPSVKRERQPFKVLATETLSEKALEADIYNAVPTEKVDGTCCYVTTYKGQPYLWARLDRRPNKQAEKRFKRFLYSVEDCKEFIWNVEEDFKPVPDTWIPAKEIEFSNGNPLPDENGHMPGWVPVEKNSKQYCWHSSVVSYETEMALVLKHHADPGLLEIRPVSLSELLEQTLELIGTNINANPYGLGSKKQPIHLLVPHGAFEIKNPPTLKQSDIVSWFEGCSEGKVEGIVWHCRDGCLIKLHRHHLGLCWPLAETYLNSQPVVISFNRNDYDCDFGPKSLFHQFSKLDGQRFDRLKDIKFDD", "length": 324, "header": "tr|A0A1L1RLE3-1|A0A1L1RLE3_CHICK Isoform 1 of RNA ligase 1 OS=Gallus gallus OX=9031 GN=C12orf29 PE=4 SV=2 CANONICAL=A0A1L1RLE3-1" }, "isoforms": [ { "isoform_ac": "A0A1L1RLE3-1", "url": "https://www.uniprot.org/uniprotkb/A0A1L1RLE3/entry#A0A1L1RLE3-1", "sequence": { "sequence": "MSRRGAVQRKVPCLFVTEVKEEPSVKRERQPFKVLATETLSEKALEADIYNAVPTEKVDGTCCYVTTYKGQPYLWARLDRRPNKQAEKRFKRFLYSVEDCKEFIWNVEEDFKPVPDTWIPAKEIEFSNGNPLPDENGHMPGWVPVEKNSKQYCWHSSVVSYETEMALVLKHHADPGLLEIRPVSLSELLEQTLELIGTNINANPYGLGSKKQPIHLLVPHGAFEIKNPPTLKQSDIVSWFEGCSEGKVEGIVWHCRDGCLIKLHRHHLGLCWPLAETYLNSQPVVISFNRNDYDCDFGPKSLFHQFSKLDGQRFDRLKDIKFDD", "length": 324, "header": "tr|A0A1L1RLE3-1|A0A1L1RLE3_CHICK Isoform 1 of RNA ligase 1 OS=Gallus gallus OX=9031 GN=C12orf29 PE=4 SV=2 CANONICAL=A0A1L1RLE3-1" }, "locus": { "chromosome": "1", "start_pos": 42855529, "end_pos": 42849535, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSGALT00010027220.1", "url": "https://www.ensembl.org/id/ENSGALT00010027220.1" }, { "database": "Ensembl Peptide", "id": "ENSGALP00010015500.1", "url": "https://www.ensembl.org/id/ENSGALP00010015500.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "F1SPZ1-1", "protein_name": "RNA ligase 1", "gene_name": "RLIG1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRRLGSVQRKMPCVFVTEVKEEPSAKREHQPFKVLATETISHKALEADIYSAIPTEKVDGTCCYVTTYKGQPYLWARLDRKPNKLAEKRFKNFLHSKQNSKEFFWNVEEDFKPVPECWIPAKDTEQLNGSPMPDENGHIPGWVPVEKNNKQYCWHSSVVNYEFEIALVLKHHSDDPGLLEISAVPLSDLLEQTLELIGTNINGNPYGLGSKKHPLHLLIPHGAFQIRNLPTLKHNDLLSWFEGCREGKIEGIVWHCNDGCLIKVHRHHLGLCWPIPDTYLNSKPVTINMNLNKYEYAFDAKCLFNYFSKIDNQKFSRLKDIVFSV", "length": 325 }, "evidence": [ { "id": "A0A1L1RLE3", "url": "https://omabrowser.org/oma/group/A0A1L1RLE3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q2KJ69-1", "protein_name": "RNA ligase 1", "gene_name": "RLIG1", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MRRLGSVQRKMPCVFVTEVKEEPSTKREHQPFKVLATETLSHKALDADIHNAIPTEKVDGTCCYVTNYKGQPYLWARLDRKPNKLAEKRFKNFLHLKQNSKEFFWNVEEDFKPVPECWIPAKEIEQINGNPIPDENGHIPGWVPVEKNSKQHCWHSSVVDYESEIALVLRHHPDDPGLLEISAVPLSDLLEQTLELIGTNINGNPYGLGSKKHPLHLLIPHGAFQIRNLPTLKHSDLLSWFDGCREGKIEGIVWHCNDGCLIKVHRHHLGLCWPIPDTYMNSKPVIINMNLNKYEYAFDAKCLFNHFSKIDNQKFGRLKDIILTV", "length": 325 }, "evidence": [ { "id": "A0A1L1RLE3", "url": "https://omabrowser.org/oma/group/A0A1L1RLE3/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "Q6AXM9-1", "protein_name": "RNA ligase 1", "gene_name": "", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MNRLGSVQRKMPCVFVTEVKAEPSAKREHQPFKVLATETLSEKALDADVYNAVATEKVDGTCCYVTNYKGQPYLWARLDRKPNKQADKRFKKFLHSKENAKEFHWNTEEDFKPVPECWIPAKEIEKQNGKPVPDENGHIPGWVPVEKNSKQYCWHSSVVSYEFGIALVLRHHPDDPGVLEISAVPLSELLEQTLELIGTNINGNPYGLGSKKYPLHFLTPHGAFQVRNLPTLKHNDLLSWFEGCREGQIEGIVWHCGDGCLIKVHRHHLGLCWPLPDTYMNSKPVIINMNLDKYDCAFDHQSLFNKFSKIDKQKFDRLKDITLDI", "length": 325 }, "evidence": [ { "id": "A0A1L1RLE3", "url": "https://omabrowser.org/oma/group/A0A1L1RLE3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8BHN7-1", "protein_name": "RNA ligase 1", "gene_name": "", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKRLGSVQRKMPCVFVTEVKAEPSAKREHQPFKVLATETLSEKALDADVYNAVATEKVDGTCCYVTNYKGQPYLWARLDRKPNKQADKRFKKFLHSKESAKEFHWNTEEDFKPVPECWIPAKEIEKQNGKPVPDENGHIPGWVPVEKGSKQYCWHSSVVNYEFGIALVLRHHPDDPGVLEISAVPLSELLEQTLELIGTSINGNPYGLGSKKSPLHFLTPHGAFQVRNLPTLKHNDLLSWFEDCREGQIEGIVWHCGDGCLIKVHRHHLGLCWPLPDTYMNSKPVIINMNLNLNNYDCAFDNQSLFNQFSKIDKQKFERLKDIILDV", "length": 327 }, "evidence": [ { "id": "A0A1L1RLE3", "url": "https://omabrowser.org/oma/group/A0A1L1RLE3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8N999-1", "protein_name": "RNA ligase 1", "gene_name": "RLIG1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKRLGSVQRKMPCVFVTEVKEEPSSKREHQPFKVLATETVSHKALDADIYSAIPTEKVDGTCCYVTTYKDQPYLWARLDRKPNKQAEKRFKNFLHSKENPKEFFWNVEEDFKPAPECWIPAKETEQINGNPVPDENGHIPGWVPVEKNNKQYCWHSSVVNYEFEIALVLKHHPDDSGLLEISAVPLSDLLEQTLELIGTNINGNPYGLGSKKHPLHLLIPHGAFQIRNLPSLKHNDLVSWFEDCKEGKIEGIVWHCSDGCLIKVHRHHLGLCWPIPDTYMNSRPVIINMNLNKCDSAFDIKCLFNHFLKIDNQKFVRLKDIIFDV", "length": 325 }, "evidence": [ { "id": "A0A1L1RLE3", "url": "https://omabrowser.org/oma/group/A0A1L1RLE3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "response to reactive oxygen species", "id": "GO:0000302", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000302", "evidence": [ { "database": "UniProtKB", "id": "A0A1L1RLE3", "url": "https://www.uniprot.org/uniprot/A0A1L1RLE3" } ], "pmid": "" }, { "name": "RNA repair", "id": "GO:0042245", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042245", "evidence": [ { "database": "UniProtKB", "id": "A0A1L1RLE3", "url": "https://www.uniprot.org/uniprot/A0A1L1RLE3" } ], "pmid": "" }, { "name": "hematopoietic progenitor cell differentiation", "id": "GO:0002244", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002244", "evidence": [ { "database": "UniProtKB", "id": "A0A1L1RLE3", "url": "https://www.uniprot.org/uniprot/A0A1L1RLE3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "RNA ligase (ATP) activity", "id": "GO:0003972", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003972", "evidence": [ { "database": "UniProtKB", "id": "A0A1L1RLE3", "url": "https://www.uniprot.org/uniprot/A0A1L1RLE3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A1L1RLE3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 324, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A1L1RLE3-F1.pdb" } ], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "6.5.1.3", "ec_name": "ATP + (ribonucleotide)n-3'-hydroxyl + 5'-phospho-(ribonucleotide)m = (ribonucleotide)n+m + AMP + diphosphate.", "evidence": [] } ], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }