{ "uniprot_canonical_ac": "A0A1L1RKB7-1", "uniprot_ac": "A0A1L1RKB7", "uniprot_id": "A0A1L1RKB7_CHICK", "mass": { "chemical_mass": 114779.0, "monoisotopic_mass": 114779.0 }, "refseq": { "ac": "NP_001258903", "name": "sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258903" }, "gene_names": [ { "name": "ATP2A2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A1L1RKB7", "id": "A0A1L1RKB7" }, { "name": "ATP2A2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258903", "id": "NP_001258903" }, { "name": "SERCA2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258903", "id": "NP_001258903" } ], "protein_names": [ { "name": "Calcium-transporting ATPase", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A1L1RKB7/entry#names_and_taxonomy", "id": "A0A1L1RKB7" }, { "name": "7.2.2.10", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A1L1RKB7/entry#names_and_taxonomy", "id": "A0A1L1RKB7" }, { "name": "sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258903", "id": "NP_001258903" }, { "name": "sarcoplasmic/endoplasmic reticulum calcium ATPase 2; calcium pump 2; endoplasmic reticulum class 1/2 Ca(2+) ATPase; SR Ca(2+)-ATPase 2; ATPase, Ca++ transporting, cardiac muscle, slow twitch 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258903", "id": "NP_001258903" } ], "function": [ { "annotation": "##Evidence-Data-START## Transcript exon combination :: SRR13267655.251676.1, SRR13267658.12997.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000260.1. Sequence Note:.", "evidence": [ { "database": "RefSeq", "id": "NP_001258903", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258903" } ] }, { "annotation": "Catalyzes the hydrolysis of ATP coupled with the transport of calcium.", "evidence": [ { "database": "UniProtKB", "id": "A0A8V1A667", "url": "https://www.uniprot.org/uniprot/A0A8V1A667#function" }, { "database": "UniProtKB", "id": "RU361146", "url": "https://www.uniprot.org/uniprot/RU361146#function" }, { "database": "UniProtKB", "id": "A0A1L1RKB7", "url": "https://www.uniprot.org/uniprot/A0A1L1RKB7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Gallus gallus", "taxid": 9031, "evidence": [ { "database": "UniProtKB", "id": "A0A1L1RKB7", "url": "https://www.uniprot.org/uniprot/A0A1L1RKB7" } ], "common_name": "Chicken", "glygen_name": "Chicken", "reference_species": "Gallus gallus [9031]" } ], "gene": [ { "name": "ATP2A2", "url": "https://www.uniprot.org/uniprot/A0A1L1RKB7", "locus": { "chromosome": "15", "start_pos": 5319274, "end_pos": 5360262, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSGALG00010025130", "url": "https://www.ensembl.org/id/ENSGALG00010025130" } ] } } ], "crossref": [ { "id": "A0A1L1RKB7", "url": "https://alphafold.ebi.ac.uk/entry/A0A1L1RKB7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSGALG00000032287", "url": "https://bgee.org/?page=gene&gene_id=ENSGALG00000032287", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02083", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02083", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "396446", "url": "https://www.ncbi.nlm.nih.gov/gene/396446", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001757", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001757", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004014", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004014", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005782", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005782", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006068", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006068", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008250", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008250", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018303", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018303", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023214", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023214", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023298", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023298", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023299", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023299", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036412", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036412", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044492", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044492", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "gga:396446", "url": "https://www.genome.jp/dbget-bin/www_bget?gga:396446", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PLWNNMM", "url": "https://omabrowser.org/oma/group/PLWNNMM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A1L1RKB7", "url": "https://www.orthodb.org/?gene=A0A1L1RKB7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR42861", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42861", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR42861:SF18", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42861:SF18", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00122", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00122", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00689", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00689", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00690", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00690", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00702", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00702", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF13246", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13246", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "R-GGA-418359", "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-418359", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-GGA-5578775", "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-5578775", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-GGA-936837", "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-936837", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001258903", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258903", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "18105", "url": "https://www.rhea-db.org/rhea/18105", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A1L1RKB7", "url": "https://www.uniprot.org/uniprot/A0A1L1RKB7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1L1RKB7-1", "url": "https://www.uniprot.org/uniprot/A0A1L1RKB7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V1A667", "url": "https://www.uniprot.org/uniprot/A0A8V1A667", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V1A667-1", "url": "https://www.uniprot.org/uniprot/A0A8V1A667-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MENAHTKTVEEVLAYFGVNESTGLSLEQVKKLKEKWGSNELPAEEGKTLLELVIEQFEDLLVRILLLAACISFVLAWFEEGEETITAFVEPFVILLILVANAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSVQRIKARDIVPGDIVEVAVGDKVPADIRITSIKSTTLRVDQSILTGESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKAMGVVIATGVNTEIGKIRDEMVATEQERTPLQQKLDEFGEQLSKVISLICIAVWIINIGHFNDPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFILDKVEGDSCSLNEFTVTGSTYAPMGEVHKDDKLIKCSQYDGLVELATICALCNDSSLDYNEAKGVYEKVGEATETALTCLVEKMNVFDTDLKGLSRIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTPNKPSRTSMSKMFVKGAPEGVIDRCTHVRVGNAKIPLSSGIKQKIMSVIREWGTGRDTLRCLALATHDNPPRKEEMNLEDSSNFINYETNLTFVGCVGMLDPPRIEVASSIKLCKQAGIRVIMITGDNKGTAVAICRRIGIFVEDEDVSTKAFTGREFDELSLAAQRDACHHARCFARVEPSHKSKIVEFLQSFDEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMNKPPRNPKEPLISGWLFFRYLAIGCYVGAATVGAAAWWFIAADGGPRVTFYQLSHFLQCKEDNPDFSGVDCVVFESPYPMTMALSVLVTIEMCNALNSLSENQSLMRMPPWENIWLVGAICLSMSLHFLILYVEPLPIIFQITPLNVTQWLMVLKISLPVILLDETLKYVARNYLEPGKDSVQPATKPCSLSACTEGVSWPFVFITLPLVIWLYSTDTNFSDMFWS", "length": 1042, "header": "tr|A0A1L1RKB7-1|A0A1L1RKB7_CHICK Isoform 1 of Calcium-transporting ATPase OS=Gallus gallus OX=9031 GN=ATP2A2 PE=3 SV=2 CANONICAL=A0A1L1RKB7-1" }, "isoforms": [ { "isoform_ac": "A0A1L1RKB7-1", "url": "https://www.uniprot.org/uniprotkb/A0A1L1RKB7/entry#A0A1L1RKB7-1", "sequence": { "sequence": "MENAHTKTVEEVLAYFGVNESTGLSLEQVKKLKEKWGSNELPAEEGKTLLELVIEQFEDLLVRILLLAACISFVLAWFEEGEETITAFVEPFVILLILVANAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSVQRIKARDIVPGDIVEVAVGDKVPADIRITSIKSTTLRVDQSILTGESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKAMGVVIATGVNTEIGKIRDEMVATEQERTPLQQKLDEFGEQLSKVISLICIAVWIINIGHFNDPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFILDKVEGDSCSLNEFTVTGSTYAPMGEVHKDDKLIKCSQYDGLVELATICALCNDSSLDYNEAKGVYEKVGEATETALTCLVEKMNVFDTDLKGLSRIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTPNKPSRTSMSKMFVKGAPEGVIDRCTHVRVGNAKIPLSSGIKQKIMSVIREWGTGRDTLRCLALATHDNPPRKEEMNLEDSSNFINYETNLTFVGCVGMLDPPRIEVASSIKLCKQAGIRVIMITGDNKGTAVAICRRIGIFVEDEDVSTKAFTGREFDELSLAAQRDACHHARCFARVEPSHKSKIVEFLQSFDEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMNKPPRNPKEPLISGWLFFRYLAIGCYVGAATVGAAAWWFIAADGGPRVTFYQLSHFLQCKEDNPDFSGVDCVVFESPYPMTMALSVLVTIEMCNALNSLSENQSLMRMPPWENIWLVGAICLSMSLHFLILYVEPLPIIFQITPLNVTQWLMVLKISLPVILLDETLKYVARNYLEPGKDSVQPATKPCSLSACTEGVSWPFVFITLPLVIWLYSTDTNFSDMFWS", "length": 1042, "header": "tr|A0A1L1RKB7-1|A0A1L1RKB7_CHICK Isoform 1 of Calcium-transporting ATPase OS=Gallus gallus OX=9031 GN=ATP2A2 PE=3 SV=2 CANONICAL=A0A1L1RKB7-1" }, "locus": { "chromosome": "15", "start_pos": 5360041, "end_pos": 5325152, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSGALT00010061313.1", "url": "https://www.ensembl.org/id/ENSGALT00010061313.1" }, { "database": "Ensembl Peptide", "id": "ENSGALP00010037911.1", "url": "https://www.ensembl.org/id/ENSGALP00010037911.1" } ] } }, { "isoform_ac": "A0A8V1A667-1", "url": "https://www.uniprot.org/uniprotkb/A0A1L1RKB7/entry#A0A8V1A667-1", "sequence": { "sequence": "MENAHTKTVEEVLAYFGVNESTGLSLEQVKKLKEKWGSNELPAEEGKTLLELVIEQFEDLLVRILLLAACISFVLAWFEEGEETITAFVEPFVILLILVANAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSVQRIKARDIVPGDIVEVAVGDKVPADIRITSIKSTTLRVDQSILTGESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKAMGVVIATGVNTEIGKIRDEMVATEQERTPLQQKLDEFGEQLSKVISLICIAVWIINIGHFNDPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFILDKVEGDSCSLNEFTVTGSTYAPMGEVHKDDKLIKCSQYDGLVELATICALCNDSSLDYNEAKGVYEKVGEATETALTCLVEKMNVFDTDLKGLSRIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTPNKPSRTSMSKMFVKGAPEGVIDRCTHVRVGNAKIPLSSGIKQKIMSVIREWGTGRDTLRCLALATHDNPPRKEEMNLEDSSNFINYETNLTFVGCVGMLDPPRIEVASSIKLCKQAGIRVIMITGDNKGTAVAICRRIGIFVEDEDVSTKAFTGREFDELSLAAQRDACHHARCFARVEPSHKSKIVEFLQSFDEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMNKPPRNPKEPLISGWLFFRYLAIGCYVGAATVGAAAWWFIAADGGPRVTFYQLSHFLQCKEDNPDFSGVDCVVFESPYPMTMALSVLVTIEMCNALNRFVSPDQVGGFCIAYLKSYLLRSPALSLWTAQLINNESYFLSDSW", "length": 958, "header": "tr|A0A8V1A667-1|A0A8V1A667_CHICK Computationally mapped isoform of Calcium-transporting ATPase OS=Gallus gallus OX=9031 GN=ATP2A2 PE=3 SV=1 CANONICAL=A0A1L1RKB7-1" }, "locus": { "chromosome": "15", "start_pos": 5360041, "end_pos": 5326422, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSGALT00010061309.1", "url": "https://www.ensembl.org/id/ENSGALT00010061309.1" }, { "database": "Ensembl Peptide", "id": "ENSGALP00010037908.1", "url": "https://www.ensembl.org/id/ENSGALP00010037908.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "gga:396446", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?gga:396446", "resource": "KEGG Pathway" }, { "id": "R-GGA-418359", "name": "Reduction of cytosolic Ca++ levels", "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-418359", "resource": "Reactome", "description": "Reduction of cytosolic Ca++ levels" }, { "id": "R-GGA-5578775", "name": "Ion homeostasis", "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-5578775", "resource": "Reactome", "description": "Ion homeostasis" }, { "id": "R-GGA-936837", "name": "Ion transport by P-type ATPases", "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-936837", "resource": "Reactome", "description": "Ion transport by P-type ATPases" } ], "orthologs": [ { "uniprot_canonical_ac": "A0AAA9SIU9-1", "protein_name": "Calcium-transporting ATPase", "gene_name": "ATP2A2", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MENAHTKTVEEVLGHFGVNESTGLSLEQVKKLKERWGSNELPAEEGKTLLELVIEQFEDLLVRILLLAACISFVLAWFEEGEETITAFVEPFVILLILIANAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSVQRIKAKDIVPGDIVEIAVGDKVPADIRLTSIKSTTLRVDQSILTGESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQERTPLQQKLDEFGEQLSKVISLICIAVWIINIGHFNDPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFILDKVEGDTCSLNEFTITGSTYAPIGEIHKDDKPVKCHQYDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKMNVFDTELKGLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTPNKPSRTSMSKMFVKGAPEGVIDRCTHIRVGSTKVPMTPGVKQKIMSVIREWGSGSDTLRCLALATHDNPLRREEMNLEDSANFIKYETNLTFVGCVGMLDPPRIEVASSVKLCRQAGIRVIMITGDNKGTAVAICRRIGIFRQDEDVTAKAFTGREFDELSPSAQREACLNARCFARVEPSHKSKIVEFLQSFDEITAMTGDGVNDAPALKKSEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMNKPPRNPKEPLISGWLFFRYLAIGCYVGAATVGAAAWWFIAAEGGPRVSFYQLSHFLQCKEDNPDFEGVDCAVFESPYPMTMALSVLVTIEMCNALNSLSENQSLLRMPPWENIWLVGSICLSMSLHFLILYVEPLPLIFQITPLNVTQWLMVLKISLPVILMDETLKFVARNYLEPGKECVQPATKPCSFSACTDGISWPFVLLIMPLVVWVYSTDTNFSDMFWS", "length": 1042 }, "evidence": [ { "id": "A0A1L1RKB7", "url": "https://omabrowser.org/oma/group/A0A1L1RKB7/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "O55143-1", "protein_name": "Sarcoplasmic/endoplasmic reticulum calcium ATPase 2", "gene_name": "Atp2a2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MENAHTKTVEEVLGHFGVNESTGLSLEQVKKLKERWGSNELPAEEGKTLLELVIEQFEDLLVRILLLAACISFVLAWFEEGEETITAFVEPFVILLILVANAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSVQRIKAKDIVPGDIVEIAVGDKVPADIRLTSIKSTTLRVDQSILTGESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQERTPLQQKLDEFGEQLSKVISLICIAVWIINIGHFNDPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFILDKVEGDTCSLNEFSITGSTYAPIGEVQKDDKPVKCHQYDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKMNVFDTELKGLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTPNKPSRTSMSKMFVKGAPEGVIDRCTHIRVGSTKVPMTPGVKQKIMSVIREWGSGSDTLRCLALATHDNPLKREEMHLEDSANFIKYETNLTFVGCVGMLDPPRIEVASSVKLCRQAGIRVIMITGDNKGTAVAICRRIGIFGQDEDVTSKAFTGREFDELSPSAQRDACLNARCFARVEPSHKSKIVEFLQSFDEITAMTGDGVNDAPALKKSEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMNKPPRNPKEPLISGWLFFRYLAIGCYVGAATVGAAAWWFIAADGGPRVSFYQLSHFLQCKEDNPDFDGVDCAIFESPYPMTMALSVLVTIEMCNALNSLSENQSLLRMPPWENIWLVGSICLSMSLHFLILYVEPLPLIFQITPLNLTQWLMVLKISLPVILMDETLKFVARNYLEQPGKECVQPATKSSCSLSACTDGISWPFVLLIMPLVVWVYSTDTNFSDMFWS", "length": 1044 }, "evidence": [ { "id": "A0A1L1RKB7", "url": "https://omabrowser.org/oma/group/A0A1L1RKB7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P11507-1", "protein_name": "Sarcoplasmic/endoplasmic reticulum calcium ATPase 2", "gene_name": "Atp2a2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MENAHTKTVEEVLGHFGVNESTGLSLEQVKKLKERWGSNELPAEEGKTLLELVIEQFEDLLVRILLLAACISFVLAWFEEGEETITAFVEPFVILLILVANAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSVQRIKAKDIVPGDIVEIAVGDKVPADIRLTSIKSTTLRVDQSILTGESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQERTPLQQKLDEFGEQLSKVISLICIAVWIINIGHFNDPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFILDKVEGDTCSLNEFTITGSTYAPIGEVQKDDKPVKCHQYDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKMNVFDTELKGLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTPNKPSRTSMSKMFVKGAPEGVIDRCTHIRVGSTKVPMTPGVKQKIMSVIREWGSGSDTLRCLALATHDNPLRREEMHLEDSANFIKYETNLTFVGCVGMLDPPRIEVASSVKLCRQAGIRVIMITGDNKGTAVAICRRIGIFGQDEDVTSKAFTGREFDELSPSAQRDACLNARCFARVEPSHKSKIVEFLQSFDEITAMTGDGVNDAPALKKSEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMNKPPRNPKEPLISGWLFFRYLAIGCYVGAATVGAAAWWFIAADGGPRVSFYQLSHFLQCKEDNPDFEGVDCAIFESPYPMTMALSVLVTIEMCNALNSLSENQSLLRMPPWENIWLVGSICLSMSLHFLILYVEPLPLIFQITPLNLTQWLMVLKISLPVILMDETLKFVARNYLEPGKECAQPATKPSCSLSACTDGISWPFVLLIMPLVVWVYSTDTNFSDMFWS", "length": 1043 }, "evidence": [ { "id": "A0A1L1RKB7", "url": "https://omabrowser.org/oma/group/A0A1L1RKB7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P11607-1", "protein_name": "Sarcoplasmic/endoplasmic reticulum calcium ATPase 2", "gene_name": "ATP2A2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MENAHTKTVEEVLGHFGVNESTGLSLEQVKKLKERWGSNELPAEEGKTLLELVIEQFEDLLVRILLLAACISFVLAWFEEGEETITAFVEPFVILLILVANAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSVQRIKAKDIVPGDIVEIAVGDKVPADIRLTSIKSTTLRVDQSILTGESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQERTPLQQKLDEFGEQLSKVISLICIAVWIINIGHFNDPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFILDKVEGDTCSLNEFTITGSTYAPIGEVHKDDKPVKCHQYDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKMNVFDTELKGLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTPNKPSRTSMSKMFVKGAPEGVIDRCTHIRVGSTKVPMTPGVKQKIMSVIREWGSGSDTLRCLALATHDNPMRREEMNLEDSANFIKYETNLTFVGCVGMLDPPRIEVASSVKLCRQAGIRVIMITGDNKGTAVAICRRIGIFGQDEDVTSKAFTGREFDELNPSAQREACLNARCFARVEPSHKSKIVEFLQSFDEITAMTGDGVNDAPALKKSEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMNKPPRNPKEPLISGWLFFRYLAIGCYVGAATVGAAAWWFIAADGGPRVTFYQLSHFLQCKEDNPDFEGVDCAVFESPYPMTMALSVLVTIEMCNALNSLSENQSLLRMPPWENIWLVGSICLSMSLHFLILYVEPLPLIFQITPLNLTQWLMVLKISLPVILMDETLKFVARNYLEPGKECVQPATKSCSFSACTDGISWPFVLLIMPLVIWVYSTDTNFSDMFWS", "length": 1042 }, "evidence": [ { "id": "A0A1L1RKB7", "url": "https://omabrowser.org/oma/group/A0A1L1RKB7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P16615-1", "protein_name": "Sarcoplasmic/endoplasmic reticulum calcium ATPase 2", "gene_name": "ATP2A2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MENAHTKTVEEVLGHFGVNESTGLSLEQVKKLKERWGSNELPAEEGKTLLELVIEQFEDLLVRILLLAACISFVLAWFEEGEETITAFVEPFVILLILVANAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSVQRIKAKDIVPGDIVEIAVGDKVPADIRLTSIKSTTLRVDQSILTGESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQERTPLQQKLDEFGEQLSKVISLICIAVWIINIGHFNDPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFILDRVEGDTCSLNEFTITGSTYAPIGEVHKDDKPVNCHQYDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKMNVFDTELKGLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTPNKPSRTSMSKMFVKGAPEGVIDRCTHIRVGSTKVPMTSGVKQKIMSVIREWGSGSDTLRCLALATHDNPLRREEMHLEDSANFIKYETNLTFVGCVGMLDPPRIEVASSVKLCRQAGIRVIMITGDNKGTAVAICRRIGIFGQDEDVTSKAFTGREFDELNPSAQRDACLNARCFARVEPSHKSKIVEFLQSFDEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMNKPPRNPKEPLISGWLFFRYLAIGCYVGAATVGAAAWWFIAADGGPRVSFYQLSHFLQCKEDNPDFEGVDCAIFESPYPMTMALSVLVTIEMCNALNSLSENQSLLRMPPWENIWLVGSICLSMSLHFLILYVEPLPLIFQITPLNVTQWLMVLKISLPVILMDETLKFVARNYLEPGKECVQPATKSCSFSACTDGISWPFVLLIMPLVIWVYSTDTNFSDMFWS", "length": 1042 }, "evidence": [ { "id": "A0A1L1RKB7", "url": "https://omabrowser.org/oma/group/A0A1L1RKB7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P22700-1", "protein_name": "Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type", "gene_name": "SERCA", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MEDGHSKTVEQSLNFFGTDPERGLTLDQIKANQKKYGPNELPTEEGKSIWQLVLEQFDDLLVKILLLAAIISFVLALFEEHEETFTAFVEPLVILLILIANAVVGVWQERNAESAIEALKEYEPEMGKVVRQDKSGIQKVRAKEIVPGDLVEVSVGDKIPADIRITHIYSTTLRIDQSILTGESVSVIKHTDAIPDPRAVNQDKKNILFSGTNVAAGKARGVVIGTGLSTAIGKIRTEMSETEEIKTPLQQKLDEFGEQLSKVISVICVAVWAINIGHFNDPAHGGSWIKGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFIFDKVEGNDSSFLEFEMTGSTYEPIGEVFLNGQRIKAADYDTLQELSTICIMCNDSAIDYNEFKQAFEKVGEATETALIVLAEKLNSFSVNKSGLDRRSAAIACRGEIETKWKKEFTLEFSRDRKSMSSYCTPLKASRLGTGPKLFVKGAPEGVLERCTHARVGTTKVPLTSALKAKILALTGQYGTGRDTLRCLALAVADSPMKPDEMDLGDSTKFYQYEVNLTFVGVVGMLDPPRKEVFDSIVRCRAAGIRVIVITGDNKATAEAICRRIGVFAEDEDTTGKSYSGREFDDLSPTEQKAAVARSRLFSRVEPQHKSKIVEFLQSMNEISAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLADDNFSSIVSAVEEGRAIYNNMKQFIRYLISSNIGEVVSIFLTAALGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKPPRKADEGLISGWLFFRYMAIGFYVGAATVGAAAWWFVFSDEGPKLSYWQLTHHLSCLGGGDEFKGVDCKIFSDPHAMTMALSVLVTIEMLNAMNSLSENQSLITMPPWCNLWLIGSMALSFTLHFVILYVDVLSTVFQVTPLSAEEWITVMKFSIPVVLLDETLKFVARKIADGESPIYKMHGIVLMWAVFFGLLYAMML", "length": 1020 }, "evidence": [ { "id": "A0A1L1RKB7", "url": "https://omabrowser.org/oma/group/A0A1L1RKB7/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q03669-1", "protein_name": "Sarcoplasmic/endoplasmic reticulum calcium ATPase 2", "gene_name": "ATP2A2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MENAHTKTVEEVLAYFGVNESTGLSLEQVKKLKEKWGSNELPAEEGKTLLELVIEQFEDLLVRILLLAACISFVLAWFEEGEETITAFVEPFVILLILVANAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSVQRIKARDIVPGDIVEVAVGDKVPADIRITSIKSTTLRVDQSILTGESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKAMGVVIATGVNTEIGKIRDEMVATEQERTPLQQKLDEFGEQLSKVISLICIAVWIINIGHFNDPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFILDKVEGDSCSLNEFTVTGSTYAPMGEVHKDDKLIKCSQYDGLVELATICALCNDSSLDYNEAKGVYEKVGEATETALTCLVEKMNVFDTDLKGLSRIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTPNKPSRTSMSKMFVKGAPEGVIDRCTHVRVGNAKIPLSSGIKQKIMSVIREWGTGRDTLRCLALATHDNPPRKEEMNLEDSSNFINYETNLTFVGCVGMLDPPRIEVASSIKLCKQAGIRVIMITGDNKGTAVAICRRIGIFVEDEDVSTKAFTGREFDELSLAAQRDACHHARCFARVEPSHKSKIVEFLQSFDEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMNKPPRNPKEPLISGWLFFRYLAIGCYVGAATVGAAAWWFIAADGGPRVTFYQLSHFLQCKEDNPDFSGVDCVVFESPYPMTMALSVLVTIEMCNALNSLSENQSLMRMPPWENIWLVGAICLSMSLHFLILYVEPLPIIFQITPLNVTQWLMVLKISLPVILLDETLKYVARNYLEPGKDSVQPATKPCSLSACTEGVSWPFVFITLPLVIWLYSTDTNFSDMFW", "length": 1041 }, "evidence": [ { "id": "A0A1L1RKB7", "url": "https://omabrowser.org/oma/group/A0A1L1RKB7/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q9SY55-1", "protein_name": "Calcium-transporting ATPase 3, endoplasmic reticulum-type", "gene_name": "ECA3", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MEDAYARSVSEVLDFFGVDPTKGLSDSQVVHHSRLYGRNVLPEEKRTPFWKLVLKQFDDLLVKILIVAAIVSFVLALANGETGLTAFLEPFVILLILAANAAVGVITETNAEKALEELRAYQANIATVLRNGCFSILPATELVPGDIVEVTVGCKIPADLRMIEMSSNTFRVDQAILTGESCSVEKDVDCTLTTNAVYQDKKNILFSGTDVVAGRGRAVVIGVGSNTAMGSIHDSMLQTDDEATPLKKKLDEFGSFLAKVIAGICVLVWVVNIGHFSDPSHGGFFKGAIHYFKIAVALAVAAIPEGLPAVVTTCLALGTKKMARLNAIVRSLPSVETLGCTTVICSDKTGTLTTNMMSVSKICVVQSAEHGPMINEFTVSGTTYAPEGTVFDSNGMQLDLPAQSPCLHHLAMCSSLCNDSILQYNPDKDSYEKIGESTEVALRVLAEKVGLPGFDSMPSALNMLSKHERASYCNHYWENQFKKVYVLEFTRDRKMMSVLCSHKQMDVMFSKGAPESIIARCNKILCNGDGSVVPLTAAGRAELESRFYSFGDETLRCLALAFKTVPHGQQTISYDNENDLTFIGLVGMLDPPREEVRDAMLACMTAGIRVIVVTGDNKSTAESLCRKIGAFDNLVDFSGMSYTASEFERLPAVQQTLALRRMTLFSRVEPSHKRMLVEALQKQNEVVAMTGDGVNDAPALKKADIGIAMGSGTAVAKSASDMVLADDNFASIVAAVAEGRAIYNNTKQFIRYMISSNIGEVVCIFVAAVLGIPDTLAPVQLLWVNLVTDGLPATAIGFNKQDSDVMKAKPRKVGEAVVTGWLFFRYLVIGVYVGLATVAGFIWWFVYSDGGPKLTYSELMNFETCALRETTYPCSIFEDRHPSTVAMTVLVVVEMFNALNNLSENQSLLVITPRSNLWLVGSIILTMLLHVLILYVHPLAVLFSVTPLSWAEWTAVLYLSFPVIIIDELLKFLSRNTGMRFRFRLRKADLLPKDRRDK", "length": 998 }, "evidence": [ { "id": "A0A1L1RKB7", "url": "https://omabrowser.org/oma/group/A0A1L1RKB7/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 19, "go_terms": [ { "name": "autophagosome assembly", "id": "GO:0000045", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000045", "evidence": [ { "database": "UniProtKB", "id": "A0A1L1RKB7", "url": "https://www.uniprot.org/uniprot/A0A1L1RKB7" } ], "pmid": "" }, { "name": "neuron cellular homeostasis", "id": "GO:0070050", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070050", "evidence": [ { "database": "UniProtKB", "id": "A0A1L1RKB7", "url": "https://www.uniprot.org/uniprot/A0A1L1RKB7" } ], "pmid": "" }, { "name": "intracellular calcium ion homeostasis", "id": "GO:0006874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006874", "evidence": [ { "database": "UniProtKB", "id": "A0A1L1RKB7", "url": "https://www.uniprot.org/uniprot/A0A1L1RKB7" } ], "pmid": "" }, { "name": "cellular response to oxidative stress", "id": "GO:0034599", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034599", "evidence": [ { "database": "UniProtKB", "id": "A0A1L1RKB7", "url": "https://www.uniprot.org/uniprot/A0A1L1RKB7" } ], "pmid": "" }, { "name": "transition between fast and slow fiber", "id": "GO:0014883", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014883", "evidence": [ { "database": "UniProtKB", "id": "A0A1L1RKB7", "url": "https://www.uniprot.org/uniprot/A0A1L1RKB7" } ], "pmid": "" }, { "name": "cardiac muscle hypertrophy in response to stress", "id": "GO:0014898", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014898", "evidence": [ { "database": "UniProtKB", "id": "A0A1L1RKB7", "url": "https://www.uniprot.org/uniprot/A0A1L1RKB7" } ], "pmid": "" }, { "name": "calcium ion transmembrane transport", "id": "GO:0070588", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070588", "evidence": [ { "database": "UniProtKB", "id": "A0A1L1RKB7", "url": "https://www.uniprot.org/uniprot/A0A1L1RKB7" } ], "pmid": "" }, { "name": "regulation of the force of heart contraction", "id": "GO:0002026", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002026", "evidence": [ { "database": "UniProtKB", "id": "A0A1L1RKB7", "url": "https://www.uniprot.org/uniprot/A0A1L1RKB7" } ], "pmid": "" }, { "name": "regulation of cardiac muscle contraction by calcium ion signaling", "id": "GO:0010882", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010882", "evidence": [ { "database": "UniProtKB", "id": "A0A1L1RKB7", "url": "https://www.uniprot.org/uniprot/A0A1L1RKB7" } ], "pmid": "" }, { "name": "T-tubule organization", "id": "GO:0033292", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033292", "evidence": [ { "database": "UniProtKB", "id": "A0A1L1RKB7", "url": "https://www.uniprot.org/uniprot/A0A1L1RKB7" } ], "pmid": "" }, { "name": "positive regulation of cardiac muscle cell apoptotic process", "id": "GO:0010666", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010666", "evidence": [ { "database": "UniProtKB", "id": "A0A1L1RKB7", "url": "https://www.uniprot.org/uniprot/A0A1L1RKB7" } ], "pmid": "" }, { "name": "negative regulation of heart contraction", "id": "GO:0045822", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045822", "evidence": [ { "database": "UniProtKB", "id": "A0A1L1RKB7", "url": "https://www.uniprot.org/uniprot/A0A1L1RKB7" } ], "pmid": "" }, { "name": "ER-nucleus signaling pathway", "id": "GO:0006984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006984", "evidence": [ { "database": "UniProtKB", "id": "A0A1L1RKB7", "url": "https://www.uniprot.org/uniprot/A0A1L1RKB7" } ], "pmid": "" }, { "name": "positive regulation of endoplasmic reticulum calcium ion concentration", "id": "GO:0032470", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032470", "evidence": [ { "database": "UniProtKB", "id": "A0A1L1RKB7", "url": "https://www.uniprot.org/uniprot/A0A1L1RKB7" } ], "pmid": "" }, { "name": "regulation of calcium ion-dependent exocytosis of neurotransmitter", "id": "GO:1903233", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903233", "evidence": [ { "database": "UniProtKB", "id": "A0A1L1RKB7", "url": "https://www.uniprot.org/uniprot/A0A1L1RKB7" } ], "pmid": "" }, { "name": "calcium ion transport from cytosol to endoplasmic reticulum", "id": "GO:1903515", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903515", "evidence": [ { "database": "UniProtKB", "id": "A0A1L1RKB7", "url": "https://www.uniprot.org/uniprot/A0A1L1RKB7" } ], "pmid": "" }, { "name": "calcium ion import into sarcoplasmic reticulum", "id": "GO:1990036", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990036", "evidence": [ { "database": "UniProtKB", "id": "A0A1L1RKB7", "url": "https://www.uniprot.org/uniprot/A0A1L1RKB7" } ], "pmid": "" }, { "name": "autophagosome membrane docking", "id": "GO:0016240", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016240", "evidence": [ { "database": "UniProtKB", "id": "A0A1L1RKB7", "url": "https://www.uniprot.org/uniprot/A0A1L1RKB7" } ], "pmid": "" }, { "name": "mitochondrion-endoplasmic reticulum membrane tethering", "id": "GO:1990456", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990456", "evidence": [ { "database": "UniProtKB", "id": "A0A1L1RKB7", "url": "https://www.uniprot.org/uniprot/A0A1L1RKB7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 9, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0A1L1RKB7", "url": "https://www.uniprot.org/uniprot/A0A1L1RKB7" } ], "pmid": "" }, { "name": "enzyme binding", "id": "GO:0019899", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019899", "evidence": [ { "database": "UniProtKB", "id": "A0A1L1RKB7", "url": "https://www.uniprot.org/uniprot/A0A1L1RKB7" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "A0A1L1RKB7", "url": "https://www.uniprot.org/uniprot/A0A1L1RKB7" } ], "pmid": "" }, { "name": "transmembrane transporter binding", "id": "GO:0044325", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044325", "evidence": [ { "database": "UniProtKB", "id": "A0A1L1RKB7", "url": "https://www.uniprot.org/uniprot/A0A1L1RKB7" } ], "pmid": "" }, { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "A0A1L1RKB7", "url": "https://www.uniprot.org/uniprot/A0A1L1RKB7" } ], "pmid": "" }, { "name": "S100 protein binding", "id": "GO:0044548", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044548", "evidence": [ { "database": "UniProtKB", "id": "A0A1L1RKB7", "url": "https://www.uniprot.org/uniprot/A0A1L1RKB7" } ], "pmid": "" }, { "name": "P-type calcium transporter activity", "id": "GO:0005388", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005388", "evidence": [ { "database": "UniProtKB", "id": "A0A1L1RKB7", "url": "https://www.uniprot.org/uniprot/A0A1L1RKB7" } ], "pmid": "" }, { "name": "P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential", "id": "GO:0086039", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0086039", "evidence": [ { "database": "UniProtKB", "id": "A0A1L1RKB7", "url": "https://www.uniprot.org/uniprot/A0A1L1RKB7" } ], "pmid": "" }, { "name": "lncRNA binding", "id": "GO:0106222", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0106222", "evidence": [ { "database": "UniProtKB", "id": "A0A1L1RKB7", "url": "https://www.uniprot.org/uniprot/A0A1L1RKB7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0A1L1RKB7", "url": "https://www.uniprot.org/uniprot/A0A1L1RKB7" } ], "pmid": "" }, { "name": "sarcoplasmic reticulum membrane", "id": "GO:0033017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033017", "evidence": [ { "database": "UniProtKB", "id": "A0A1L1RKB7", "url": "https://www.uniprot.org/uniprot/A0A1L1RKB7" } ], "pmid": "" }, { "name": "ribbon synapse", "id": "GO:0097470", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097470", "evidence": [ { "database": "UniProtKB", "id": "A0A1L1RKB7", "url": "https://www.uniprot.org/uniprot/A0A1L1RKB7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1035, "end_pos": 1037, "annotation": "n_glycosylation_sequon" }, { "start_pos": 19, "end_pos": 21, "annotation": "n_glycosylation_sequon" }, { "start_pos": 421, "end_pos": 423, "annotation": "n_glycosylation_sequon" }, { "start_pos": 589, "end_pos": 591, "annotation": "n_glycosylation_sequon" }, { "start_pos": 738, "end_pos": 740, "annotation": "n_glycosylation_sequon" }, { "start_pos": 918, "end_pos": 920, "annotation": "n_glycosylation_sequon" }, { "start_pos": 962, "end_pos": 964, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "18105", "name": "", "equation": "ATP + Ca(2+)(in) + H2O = ADP + Ca(2+)(out) + H(+) + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q2U0I3-1", "A0A8V0Z7T1-1", "Q98SH2-1", "Q9YGL9-2", "A0A8V0YJM2-1", "A0A1D5PJX0-1", "A0A8V0XTF5-1", "A0A1L1RKB7-1", "P13585-1", "Q03669-1" ], "evidence": [ { "id": "18105", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/18105" } ] }, { "id": "R-GGA-418365", "name": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "platelet dense tubular network membrane", "input_participant_list": [ "R-ALL-74016", "R-ALL-427899" ], "output_participant_list": [ "R-ALL-139827" ], "enzyme_list": [ "A0A1L1RKB7-1" ], "evidence": [ { "id": "R-GGA-418365", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-418365" } ] }, { "id": "R-GGA-427910", "name": "ATP2A1-3 transport Ca2+ from cytosol to ER lumen", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [ "R-ALL-111875" ], "enzyme_list": [ "F1NGS8-1", "A0A1L1RKB7-1" ], "evidence": [ { "id": "R-GGA-427910", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-427910" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-111875", "participant_name": "Ca2+ [endoplasmic reticulum lumen]", "crossref": [ { "id": "C00076", "database": "COMPOUND", "url": "" }, { "id": "29108", "database": "ChEBI", "url": "" }, { "id": "HMDB0000464", "database": "HMDB Metabolite", "url": "" }, { "id": "8145461", "database": "PubChem Substance", "url": "" } ] }, { "participant_id": "R-ALL-139827", "participant_name": "Ca2+ [platelet dense tubular network lumen]", "crossref": [ { "id": "C00076", "database": "COMPOUND", "url": "" }, { "id": "29108", "database": "ChEBI", "url": "" }, { "id": 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"https://www.uniprot.org/uniprot/A0A3Q2U0I3" } ] }, { "ec_number": "7.2.2.10", "activity": "", "evidence": [ { "id": "A0A3Q2U0I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A3Q2U0I3" } ] } ] }, { "uniprot_ac": "A0A8V0XTF5", "gene_name": "ATP2C2", "activity": [ { "ec_number": "7.2.2.10", "activity": "ATP + Ca(2+)(in) + H2O = ADP + Ca(2+)(out) + H(+) + phosphate.", "evidence": [ { "id": "A0A8V0XTF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V0XTF5" } ] }, { "ec_number": "7.2.2.10", "activity": "", "evidence": [ { "id": "A0A8V0XTF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V0XTF5" } ] } ] }, { "uniprot_ac": "A0A8V0YJM2", "gene_name": "ATP2B1", "activity": [ { "ec_number": "7.2.2.10", "activity": "ATP + Ca(2+)(in) + H2O = ADP + Ca(2+)(out) + H(+) + phosphate.", "evidence": [ { "id": "A0A8V0YJM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V0YJM2" } ] }, { "ec_number": "7.2.2.10", "activity": "", "evidence": [ { "id": "A0A8V0YJM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V0YJM2" } ] } ] }, { "uniprot_ac": "A0A8V0Z7T1", "gene_name": "ATP2C1", "activity": [ { "ec_number": "7.2.2.10", "activity": "ATP + Ca(2+)(in) + H2O = ADP + Ca(2+)(out) + H(+) + phosphate.", "evidence": [ { "id": "A0A8V0Z7T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V0Z7T1" } ] }, { "ec_number": "7.2.2.10", "activity": "", "evidence": [ { "id": "A0A8V0Z7T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V0Z7T1" } ] } ] }, { "uniprot_ac": "F1NGS8", "gene_name": "CAMK2A", "activity": [ { "ec_number": "2.7.11.17", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "F1NGS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1NGS8" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F1NGS8", "database": "UniProtKB", "url": 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