{ "uniprot_canonical_ac": "A0A1D5PYC2-1", "uniprot_ac": "A0A1D5PYC2", "uniprot_id": "A0A1D5PYC2_CHICK", "mass": { "chemical_mass": 109807.0, "monoisotopic_mass": 109807.0 }, "refseq": { "ac": "XP_015132171", "name": "inositol polyphosphate 4-phosphatase type II isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015132171" }, "gene_names": [ { "name": "INPP4B", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A1D5PYC2", "id": "A0A1D5PYC2" }, { "name": "INPP4B", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015132171", "id": "XP_015132171" } ], "protein_names": [ { "name": "phosphatidylinositol-3,4-bisphosphate 4-phosphatase", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PYC2/entry#names_and_taxonomy", "id": "A0A1D5PYC2" }, { "name": "3.1.3.66", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PYC2/entry#names_and_taxonomy", "id": "A0A1D5PYC2" }, { "name": "inositol polyphosphate 4-phosphatase type II isoform X1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015132171", "id": "XP_015132171" } ], "function": [ { "annotation": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052535.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length.", "evidence": [ { "database": "RefSeq", "id": "XP_015132171", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015132171" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Gallus gallus", "taxid": 9031, "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PYC2", "url": "https://www.uniprot.org/uniprot/A0A1D5PYC2" } ], "common_name": "Chicken", "glygen_name": "Chicken", "reference_species": "Gallus gallus [9031]" } ], "gene": [ { "name": "INPP4B", "url": "https://www.uniprot.org/uniprot/A0A1D5PYC2", "locus": { "chromosome": "4", "start_pos": 29661610, "end_pos": 29945542, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSGALG00010009381", "url": "https://www.ensembl.org/id/ENSGALG00010009381" } ] } } ], "crossref": [ { "id": "A0A1D5PYC2", "url": "https://alphafold.ebi.ac.uk/entry/A0A1D5PYC2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSGALG00000009880", "url": "https://bgee.org/?page=gene&gene_id=ENSGALG00000009880", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04048", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04048", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "422454", "url": "https://www.ncbi.nlm.nih.gov/gene/422454", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000008", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000008", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035892", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035892", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039034", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039034", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "VITGRRX", "url": "https://omabrowser.org/oma/group/VITGRRX/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A1D5PYC2", "url": "https://www.orthodb.org/?gene=A0A1D5PYC2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12187", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12187", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12187:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12187:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "R-GGA-1660499", "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-1660499", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-GGA-1660516", "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-1660516", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-GGA-1855183", "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-1855183", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "XP_015132171", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015132171", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "43388", "url": "https://www.rhea-db.org/rhea/43388", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A1D5PYC2", "url": "https://www.uniprot.org/uniprot/A0A1D5PYC2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1D5PYC2-1", "url": "https://www.uniprot.org/uniprot/A0A1D5PYC2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V0XX80", "url": "https://www.uniprot.org/uniprot/A0A8V0XX80", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V0XX80-1", "url": "https://www.uniprot.org/uniprot/A0A8V0XX80-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V0Y1Q6", "url": "https://www.uniprot.org/uniprot/A0A8V0Y1Q6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V0Y1Q6-1", "url": "https://www.uniprot.org/uniprot/A0A8V0Y1Q6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V0Y5R9", "url": "https://www.uniprot.org/uniprot/A0A8V0Y5R9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V0Y5R9-1", "url": "https://www.uniprot.org/uniprot/A0A8V0Y5R9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEIKEERASDEAQQFLPSSQIDSLGEPQLTSIQRIANEPKLEFSLACKDLVAATRDRKLNTFIQVSVVHPAEHVLTRYSSTEIVEGTRDPLFLTGVTFPPEYPIYEETKIKLTVYDVKDKSQDTVHTTVLPDHKEPRTDVGRSFLGFTTFTVGDLVKSKEQQLTLTLRTSDGGKTVGTIEVNLVNMGELEDGEPGHVTTDSQDQKLLCFLPLKSCKRGFLSAASAHNTENLERMADRKAKEECALVRECTASEGISGKDNLPSLNAVLKNPICKLYRFPTSDNKWMRIREQMAETILSFHVPKELINLHIKEDMRRNQELKDLGELAPHWDNMRKSVIAHCDQMLSMYQDTLAELGKHTGSSFKSSCSKGEKTLEFIPINLHLQRMHVHSPLLKDALYDVITVGAPAAHFQGFKNGGLRKLLSKFETERRNTGYQCIYYSPENTAKAKEVLSNINHLQPLISSHADLLLNSASQHSPDSLKNSLKMLSEKTELFVHAFKDQLVRSALLALYTARPGCVLKKPAVPRNSAEEGDDLKHQDHPSQVKRQDSIPHHSEYDEEEWDRVWANVGKSLNCVIAMVDKLLEKDNSGNTKEGETDPSTADCKHAGSDWYEQLYPLVITLKDCMGEVVTRAKQSMAFVLLQELACGLPQCLMLTLRRDIVFSQALAGLVCGFIIKLHTGLHDQGFLQQLHTVGLLVQYEGLLSTYSEEAGMLEDMAVGISDLQKVMFKVIEAKSEDFLPIITGRREHYVIEVQLPAKMFELLPQEIKEGKLLRMYPVLFNVGINEQQTLADRFGDTTLQENINQENLQLLKEYYNLFTEKMPPDCLPHFQEQNDLKGLLESLHQSIQAKKRKNVEIMWLAATICRKLNGVRFTCCKSAKDRTSMSVTLEQCSILRDEHQLHKDFFIRALDCMRSRQTQGALNDSDDPETGCLTDNKPTSRHFYPVALLLVSSHLLVVWLILSLALLLAKYQ", "length": 972, "header": "tr|A0A1D5PYC2-1|A0A1D5PYC2_CHICK Isoform 1 of phosphatidylinositol-3,4-bisphosphate 4-phosphatase OS=Gallus gallus OX=9031 GN=INPP4B PE=3 SV=2 CANONICAL=A0A1D5PYC2-1" }, "isoforms": [ { "isoform_ac": "A0A1D5PYC2-1", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PYC2/entry#A0A1D5PYC2-1", "sequence": { "sequence": "MEIKEERASDEAQQFLPSSQIDSLGEPQLTSIQRIANEPKLEFSLACKDLVAATRDRKLNTFIQVSVVHPAEHVLTRYSSTEIVEGTRDPLFLTGVTFPPEYPIYEETKIKLTVYDVKDKSQDTVHTTVLPDHKEPRTDVGRSFLGFTTFTVGDLVKSKEQQLTLTLRTSDGGKTVGTIEVNLVNMGELEDGEPGHVTTDSQDQKLLCFLPLKSCKRGFLSAASAHNTENLERMADRKAKEECALVRECTASEGISGKDNLPSLNAVLKNPICKLYRFPTSDNKWMRIREQMAETILSFHVPKELINLHIKEDMRRNQELKDLGELAPHWDNMRKSVIAHCDQMLSMYQDTLAELGKHTGSSFKSSCSKGEKTLEFIPINLHLQRMHVHSPLLKDALYDVITVGAPAAHFQGFKNGGLRKLLSKFETERRNTGYQCIYYSPENTAKAKEVLSNINHLQPLISSHADLLLNSASQHSPDSLKNSLKMLSEKTELFVHAFKDQLVRSALLALYTARPGCVLKKPAVPRNSAEEGDDLKHQDHPSQVKRQDSIPHHSEYDEEEWDRVWANVGKSLNCVIAMVDKLLEKDNSGNTKEGETDPSTADCKHAGSDWYEQLYPLVITLKDCMGEVVTRAKQSMAFVLLQELACGLPQCLMLTLRRDIVFSQALAGLVCGFIIKLHTGLHDQGFLQQLHTVGLLVQYEGLLSTYSEEAGMLEDMAVGISDLQKVMFKVIEAKSEDFLPIITGRREHYVIEVQLPAKMFELLPQEIKEGKLLRMYPVLFNVGINEQQTLADRFGDTTLQENINQENLQLLKEYYNLFTEKMPPDCLPHFQEQNDLKGLLESLHQSIQAKKRKNVEIMWLAATICRKLNGVRFTCCKSAKDRTSMSVTLEQCSILRDEHQLHKDFFIRALDCMRSRQTQGALNDSDDPETGCLTDNKPTSRHFYPVALLLVSSHLLVVWLILSLALLLAKYQ", "length": 972, "header": "tr|A0A1D5PYC2-1|A0A1D5PYC2_CHICK Isoform 1 of phosphatidylinositol-3,4-bisphosphate 4-phosphatase OS=Gallus gallus OX=9031 GN=INPP4B PE=3 SV=2 CANONICAL=A0A1D5PYC2-1" }, "locus": { "chromosome": "4", "start_pos": 29831514, "end_pos": 29663970, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSGALT00010022398.1", "url": "https://www.ensembl.org/id/ENSGALT00010022398.1" }, { "database": "Ensembl Peptide", "id": "ENSGALP00010012890.1", "url": "https://www.ensembl.org/id/ENSGALP00010012890.1" } ] } }, { "isoform_ac": "A0A8V0XX80-1", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PYC2/entry#A0A8V0XX80-1", "sequence": { "sequence": "MEIKEERASDEAQQFLPSSQIDSLGEPQLTSIQRIANEPKLEFSLACKDLVAATRDRKLNTFIQVSVVHPAEHVLTRYSSTEIVEGTRDPLFLTGVTFPPEYPIYEETKIKLTVYDVKDKSQDTVHTTVLPDHKEPRTDVGRSFLGFTTFTVGDLVKSKEQQLTLTLRTSDGGKTVGTIEVNLVNMGELEDGEPGHVTTDSQDQKCALVRECTASEGISGKDNLPSLNAVLKNPICKLYRFPTSDNKWMRIREQMAETILSFHVPKELINLHIKEDMRRNQELKDLGELAPHWDNMRKSVIAHCDQMLSMYQDTLAELGKHTGSSFKSSCSKGEKTLEFIPINLHLQRMHVHSPLLKDALYDVITVGAPAAHFQGFKNGGLRKLLSKFETERRNTGYQCIYYSPENTAKAKEVLSNINHLQPLISSHADLLLNSASQHSPDSLKNSLKMLSEKTELFVHAFKDQLVRSALLALYTARPGCVLKKPAVPRNSAEEGDDLKHQDHPSQVKRQDSIPHHSEYDEEEWDRVWANVGKSLNCVIAMVDKLLEKDNSGNTKEGETDPSTADCKHAGSDWYEQLYPLVITLKDCMGEVVTRAKQSMAFVLLQELACGLPQCLMLTLRRDIVFSQALAGLVCGFIIKLHTGLHDQGFLQQLHTVGLLVQYEGLLSTYSEEAGMLEDMAVGISDLQKVMFKVIEAKSEDFLPIITGRREHYVIEVQLPAKMFELLPQEIKEGKLLRMYPVLFNVGINEQQTLADRFGDTTLQENINQENLQLLKEYYNLFTEKMPPDCLPHFQEQNDLKGLLESLHQSIQAKKRKNVEIMWLAATICRKLNGVRFTCCKSAKDRTSMSVTLEQCSILRDEHQLHKDFFIRALDCMRRYVKIIAYPLLFELNRGLQNWPKPVANA", "length": 905, "header": "tr|A0A8V0XX80-1|A0A8V0XX80_CHICK Computationally mapped isoform of phosphatidylinositol-3,4-bisphosphate 4-phosphatase OS=Gallus gallus OX=9031 GN=INPP4B PE=3 SV=1 CANONICAL=A0A1D5PYC2-1" }, "locus": { "chromosome": "4", "start_pos": 29831514, "end_pos": 29687790, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSGALT00010022389.1", "url": "https://www.ensembl.org/id/ENSGALT00010022389.1" }, { "database": "Ensembl Peptide", "id": "ENSGALP00010012882.1", "url": "https://www.ensembl.org/id/ENSGALP00010012882.1" } ] } }, { "isoform_ac": "A0A8V0Y1Q6-1", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PYC2/entry#A0A8V0Y1Q6-1", "sequence": { "sequence": "MEIKEERASDEAQQFLPSSQIDSLGEPQLTSIQRIANEPKLEFSLACKDLVAATRDRKLNTFIQVSVVHPAEHVLTRYSSTEIVEGTRDPLFLTGVTFPPEYPIYEETKIKLTVYDVKDKSQDTVHTTVLPDHKEPRTDVGRSFLGFTTFTVGDLVKSKEQQLTLTLRTSDGGKTVGTIEVNLVNMGELEDGEPGHVTTDSQDQKCALVRECTASEGISGKDNLPSLNAVLKNPICKLYRFPTSDNKWMRIREQMAETILSFHVPKELINLHIKEDMRRNQELKDLGELAPHWDNMRKSVIAHCDQMLSMYQDTLAELGKHTGSSFKSSCSKGEKTLEFIPINLHLQRMHVHSPLLKDALYDVITVGAPAAHFQGFKNGGLRKLLSKFETERRNTGYQCIYYSPENTAKAKEVLSNINHLQPLISSHADLLLNSASQHSPDSLKNSLKMLSEKTELFVHAFKDQLVRSALLALYTARPGCVLKKPAVPRNSAEEGDDLKHQDHPSQVKRQDSIPHHSEYDEEEWDRVWANVGKSLNCVIAMVDKLLEKDNSGNTKEGETDPSTADCKHAGSDWYEQLYPLVITLKDCMGEVVTRAKQSMAFVLLQELACGLPQCLMLTLRRDIVFSQALAGLVCGFIIKLHTGLHDQGFLQQLHTVGLLVQYEGLLSTYSEEAGMLEDMAVGISDLQKVMFKVIEAKSEDFLPIITGRREHYVIEVQLPAKMFELLPQEIKEGKLLRMYPVLFNVGINEQQTLADRFGDTTLQENINQENLQLLKEYYNLFTEKMPPDCLPHFQEQNDLKGLLESLHQSIQAKKRKNVEIMWLAATICRKLNGVRFTCCKSAKDRTSMSVTLEQCSILRDEHQLHKDFFIRALDCMRRMPHRECTEECQMQKVCIQHDTADGFPKVLQTSRRDIWKN", "length": 917, "header": "tr|A0A8V0Y1Q6-1|A0A8V0Y1Q6_CHICK Computationally mapped isoform of phosphatidylinositol-3,4-bisphosphate 4-phosphatase OS=Gallus gallus OX=9031 GN=INPP4B PE=3 SV=1 CANONICAL=A0A1D5PYC2-1" }, "locus": { "chromosome": "4", "start_pos": 29831514, "end_pos": 29662614, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSGALT00010022394.1", "url": "https://www.ensembl.org/id/ENSGALT00010022394.1" }, { "database": "Ensembl Peptide", "id": "ENSGALP00010012886.1", "url": "https://www.ensembl.org/id/ENSGALP00010012886.1" } ] } }, { "isoform_ac": "A0A8V0Y5R9-1", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PYC2/entry#A0A8V0Y5R9-1", "sequence": { "sequence": "MEIKEERASDEAQQFLPSSQIDSLGEPQLTTCKDLVAATRDRKLNTFIQVSVVHPAEHVLTRYSSTEIVEGTRDPLFLTGVTFPPEYPIYEETKIKLTVYDVKDKSQDTVHTTVLPDHKEPRTDVGRSFLGFTTFTVGDLVKSKEQQLTLTLRTSDGGKTVGTIEVNLVNMGELEDGEPGHVTTDSQDQKCALVRECTASEGISGKDNLPSLNAVLKNPICKLYRFPTSDNKWMRIREQMAETILSFHVPKELINLHIKEDMRRNQELKDLGELAPHWDNMRKSVIAHCDQMLSMYQDTLAELGKHTGSSFKSSCSKGEKTLEFIPINLHLQRMHVHSPLLKDALYDVITVGAPAAHFQGFKNGGLRKLLSKFETERRNTGYQCIYYSPENTAKAKEVLSNINHLQPLISSHADLLLNSASQHSPDSLKNSLKMLSEKTELFVHAFKDQLVRSALLALYTARPGCVLKKPAVPRNSAEEGDDLKHQDHPSQVKRQDSIPHHSEYDEEEWDRVWANVGKSLNCVIAMVDKLLEKDNSGNTKEGETDPSTADCKHAGSDWYEQLYPLVITLKDCMGEVVTRAKQSMAFVLLQELACGLPQCLMLTLRRDIVFSQALAGLVCGFIIKLHTGLHDQGFLQQLHTVGLLVQYEGLLSTYSEEAGMLEDMAVGISDLQKVMFKVIEAKSEDFLPIITGRREHYVIEVQLPAKMFELLPQEIKEGKLLRMYPVLFNVGINEQQTLADRFGDTTLQENINQENLQLLKEYYNLFTEKMPPDCLPHFQEQNDLKGLLESLHQSIQAKKRKNVEIMWLAATICRKLNGVRFTCCKSAKDRTSMSVTLEQCSILRDEHQLHKDFFIRALDCMRREGCRIENVLKNVKCRKYAFNMIQLMAFPKYYRPPEGTYGKTDT", "length": 906, "header": "tr|A0A8V0Y5R9-1|A0A8V0Y5R9_CHICK Computationally mapped isoform of Inositol polyphosphate-4-phosphatase type II B OS=Gallus gallus OX=9031 GN=INPP4B PE=4 SV=1 CANONICAL=A0A1D5PYC2-1" }, "locus": { "chromosome": "4", "start_pos": 29831514, "end_pos": 29662607, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSGALT00010022386.1", "url": "https://www.ensembl.org/id/ENSGALT00010022386.1" }, { "database": "Ensembl Peptide", "id": "ENSGALP00010012880.1", "url": "https://www.ensembl.org/id/ENSGALP00010012880.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-GGA-1660499", "name": "Synthesis of PIPs at the plasma membrane", "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-1660499", "resource": "Reactome", "description": "Synthesis of PIPs at the plasma membrane" }, { "id": "R-GGA-1660516", "name": "Synthesis of PIPs at the early endosome membrane", "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-1660516", "resource": "Reactome", "description": "Synthesis of PIPs at the early endosome membrane" }, { "id": "R-GGA-1855183", "name": "Synthesis of IP2, IP, and Ins in the cytosol", "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-1855183", "resource": "Reactome", "description": "Synthesis of IP2, IP, and Ins in the cytosol" } ], "orthologs": [ { "uniprot_canonical_ac": "F1MNJ3-1", "protein_name": "phosphatidylinositol-3,4-bisphosphate 4-phosphatase", "gene_name": "INPP4B", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MEIKEEGASEEGQNFLPTPQANDTGDFQFTSIQKTPNEPQLEFILACKDLVAPVRDRKLNTLVQISVIHPAEQGLTRYSSTEIVEGTRDPLFLTGVTFPSEYPIYEETKIKLTVYDVKDKSHDTVRTSVVPEHKDPPPEVGRSFLGYASFKVGELLKSKEQVLALSLRTSDGGKVVGTIEVSVVKMGEIEDGEADNITTDVQGQKCALVCECSAPESVSRKDNLPFLNAVLKNPVCKLYRFPTSDNKWMQIREQMSESILSFHIPKELISLQIKEDLCRNQELKELGELSPHWDNLRKNVLTHCDQMVNMYQDILTELSKETGSSFKSSSSKGEKTLEFVPINLHLQRMHVHSPHLKDALYDVITVGAPAAHFQGFKNGGLRKLLHRFEAERRNTGYQFIYYSPENTAKAKEVLSNINQLQPLIAAHADLLLNSASQHSPDSLKNSLKMLSEKTELFVHAFKDQLVRSALLALYTARPGGVLKKPPSPQSGTEESISQDPPLPVRRQDSIPHHSDYDEEEWDRVWANVGKSLNCIIAMVDKLIERESGGEGSSTSSKDVEKDSSPVDSIITHPKEDWYEQLYPLILTLKDCMGEVVNRAKQSLTFVLLQELAYSLPQCLMLTLRRDIVFSQALAGLVCGFIIKLHTSLYDPGFLEQLHTVGLIVQYEGLLSTYSEEIGMLEDMAVGISDLKKVAFKIIEATSNDVLPVITGRREHYVVEVKVPARVFESLPLQIKEGQLLHVHPVLFNVGINEQQTLAERFGDVSLQESINQENFELLKEYYTVFMEKMPPDYISHFQEQNDLKGLLENLHQNIQAKKRKNVEIMWLAATICRKLNGIRFTCCKSAKDRTSMSVTLEQCSILRDEHQLHKDFFIRALDCMRREGCRIENVLKNIKCRKYAFNMLQLMAFPKYYRPPEGTYGKADT", "length": 925 }, "evidence": [ { "id": "A0A1D5PYC2", "url": "https://omabrowser.org/oma/group/A0A1D5PYC2/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "F1RRG5-1", "protein_name": "Inositol polyphosphate-4-phosphatase type II B", "gene_name": "INPP4B", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEIKEEGTSEEGQHFLPAPQANDTGDFQFTSIQKTPDEPQLEFILACKDLVAPVRDRKLNTLVQIAVVHPAEQSLTRYSCTEIVEGTRDPLFLTGVTFPSEYPIYEETKIKLTVYDVKDKSHDTVRTSVLPEHKDPLPEVGRSFLGYASFKVGELLKSKEQVLALSLRTSDGGKVVGTIEVSVVKMGEIEDGEADHITTDVQGQKCALVCECTAPESVSRKDNLPFLNAVLKNPVYKLYRFPTSDNKWMRIREQMSESILSFHIPKELISLQIKEDLCRNQELKELGELSPHWDNLRKNVLTHCDQMVNMYQDILTELSKETGSSFKSSSSKGEKSLEFVPVNLHLQRMHVHSPHLKDALYDVITVGAPAAHFQGFKNGGLRKLLHRFETERRNTEYQFIYYSPENTAKAKEVLSNINQLQPLIATHADLLLNSASQRSPDSLKNSLKMLSEKTELFVHAFKDQLVRSALLALYTARPGGVLKKPPSPKNSTEESSSQDPPPPMRRQDSIPHHSDYDEEEWDRVWANVGKSLNCIIAMVDKLIERDGFSEGSSSSKDGEKDPSLVDSTITHPKEDWYEQLYPLILTLKDCMGEVVHRAKQSLTFVLLQELAYSLPQCLMLTLRRDVVFSQALAGLVCGFVIKLHTSLYDPGFLEQLHTVGLIAQYEGLLSTYSDEIGMLEDMAVGISDLKKVAFKIIEAKSNDVLPVITGRREHYVVEVKLPARLFESLPLQIKEGQLLRVYPVLFNVGINEQQTLAERFGDVSLQESINQENFELLKEYCTVFMEKMPPDYISHFQEQNDLKGLLENLHQNIQAKKRKNVEIMWLAATICRKLNGIRFTCCKSAKDRTSMSVTLEQCSILRDEHQLHKDFFIRALDCMRREGCRIENVLKNIKCRKYAFNMLQLMAFPKYYRPPEGTYGKADT", "length": 924 }, "evidence": [ { "id": "A0A1D5PYC2", "url": "https://omabrowser.org/oma/group/A0A1D5PYC2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O15327-1", "protein_name": "Inositol polyphosphate 4-phosphatase type II", "gene_name": "INPP4B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEIKEEGASEEGQHFLPTAQANDPGDCQFTSIQKTPNEPQLEFILACKDLVAPVRDRKLNTLVQISVIHPVEQSLTRYSSTEIVEGTRDPLFLTGVTFPSEYPIYEETKIKLTVYDVKDKSHDTVRTSVLPEHKDPPPEVGRSFLGYASFKVGELLKSKEQLLVLSLRTSDGGKVVGTIEVSVVKMGEIEDGEADHITTDVQGQKCALVCECTAPESVSGKDNLPFLNSVLKNPVCKLYRFPTSDNKWMRIREQMSESILSFHIPKELISLHIKEDLCRNQEIKELGELSPHWDNLRKNVLTHCDQMVNMYQDILTELSKETGSSFKSSSSKGEKTLEFVPINLHLQRMQVHSPHLKDALYDVITVGAPAAHFQGFKNGGLRKLLHRFETERRNTGYQFIYYSPENTAKAKEVLSNINQLQPLIATHADLLLNSASQHSPDSLKNSLKMLSEKTELFVHAFKDQLVRSALLALYTARPGGILKKPPSPKSSTEESSPQDQPPVMRGQDSIPHHSDYDEEEWDRVWANVGKSLNCIIAMVDKLIERDGGSEGSGGNNDGEKEPSLTDAIPSHPREDWYEQLYPLILTLKDCMGEVVNRAKQSLTFVLLQELAYSLPQCLMLTLRRDIVFSQALAGLVCGFIIKLQTSLYDPGFLQQLHTVGLIVQYEGLLSTYSDEIGMLEDMAVGISDLKKVAFKIIEAKSNDVLPVITGRREHYVVEVKLPARMFESLPLQIKEGQLLHVYPVLFNVGINEQQTLAERFGDVSLQESINQENFELLQEYYKIFMEKMPPDYISHFQEQNDLKALLENLLQNIQSKKRKNVEIMWLAATICRKLNGIRFTCCKSAKDRTSMSVTLEQCSILRDEHQLHKDFFIRALDCMRREGCRIENVLKNIKCRKYAFNMLQLMAFPKYYRPPEGTYGKADT", "length": 924 }, "evidence": [ { "id": "A0A1D5PYC2", "url": "https://omabrowser.org/oma/group/A0A1D5PYC2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q6P1Y8-1", "protein_name": "Type II inositol 3,4-bisphosphate 4-phosphatase", "gene_name": "Inpp4b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEIKEEGTSEEGQHFLPAAQANDPEDIQFTSIQKIPNEPQLEFILACRDLVAPVSDRKLNTVVQISVIHPVEQTLTRYSSTEIVEGTKDPLFLTGVTFPPDYPIYEETRIKLTVYDVKDKSHDTRSFLGCASFKVGELLKSKEQLLSLSLRTSDGGKVVGTIEVSLVKMGEIEDGDTDHITTDVQGQKCALMYESTAPESLSGKENLPFMNAVLRNPVCKLYRFPTSDNKWMRIREQMSESILSFHIPKELISLHIKEDLCRNQELKELGDLSPHWDNLRKNVLSHCDQMVTMYQDILTELSKETGSSFKSSSSKGEKTLEFVPVNLHLQRMQVHSPHLKDALYDVITVGAPAAHFQGFKNGGLRKLLHRFETERRNTGYQFIYYSPENTAKAKEVLSSINQLQPLIATHADLLLTSASQRSPDSLKSSLKLLSEKTELFVHAFKDQLVRSALLALYTARPGGILKKPPSPNVSTEEKSTQHDTPQLRRQDSIPHHSDYDEEEWDRVWANVGKSLNCIIAKVDKLIERDSHNEEGAGGSSSKDGEADHTLEDSITSHPREDWYEQLHPLILTLKECMGEVVNRAKQSLTFVLLQELAYSLPQCLMLTLRRDIVFSQALAGLVCGFIIKLHTSLHDPGFLQQLHTVGLIVQYEGLLSTYSDEIGMLEDMAVGISDLRKVAFKITEATSNDVLPVLTGRREHYVVEVKLPATVFESLPLQIKEGQLLHVYPVLFNVGINEQQTLAERFGDVSLQESINQENFELVQEYYSIFMEKMPPDYISHFQEQTDLKGLLDNLHQNIQAKKRKNVEIMWLAATICRKLNGIRFTCCKSAKDRTSMSVTLEQCSILRDEHQLHKDFFIRALDCMRSRQTQGALNESDDPETGCLTDNKPTSRHFYPVALLLVSSHLLVVWLILSLALLLAKYQ", "length": 924 }, "evidence": [ { "id": "A0A1D5PYC2", "url": "https://omabrowser.org/oma/group/A0A1D5PYC2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9QWG5-1", "protein_name": "Type II inositol 3,4-bisphosphate 4-phosphatase", "gene_name": "Inpp4b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEIKEEGTSEEGQHFLPAAQANDPEDIQFTSIQKSPNEPQLEFILACKDLVAPVSDRKLNTVVQVSVIHPVEQTLTRYSSTEIVEGTKDPLFLTGVTFPSDYPIYEETRIKLTVYDVKDKPHDTIRTSVLPEHKDPPPEVARSFLGCASFKVGELLKSKEQLLSLSLRTSDGGKVVGTIEVSLVKMGEIEDGDTDHITTDVQGQKCALVYDSTAPESLSGKENLPFMNAVLRNPVCKLYRFPTSDNKWMRIREQMSESILSFHIPKELISLHIKEDLCRNQELKELGDLSPHWDNLRNNVLSHCDQMVTMYQDILTELSKETGSSFKSSSSKGEKTLEFVPINLHLQRMQVHSPHLKDALYDVITVGAPAAHFQGFKNGGLRKLLHRFETERRNTGYQFIYYSPENTAKAKEVLSSINQLQPLVATHADLLLTSASQHSPDSLRSSLKLLSEKTELFVHAFKDQLVRSALLALYTARPGGILRKPPSPKVSTEEKSSQHDSPQQLRRQDSIPHHSDYDEEEWDRVWANVGKSLNCIIAKVDKLIERDSRNDKSTGGDSSKDGDADPNLEDSLTSHPREDWYEQLHPLILTLKECMAEVVNRAKQSLTFVLLQELAYSLPQCLMLTLRRDIVFSQALAGLVCGFIIKLHTSLHDPGFLQQLHTVGLIVQYEGLLSTYSDEIGMLEDMAVGISDLRKVAFKITEATSNDVLPVLTGRREHYVVEVKLPATVFESLPLQIKEGQLLHVYPVLFNVGINEQQTLAERFGDVSLQESINQENFELVQEYYSIFMEKMPPDYISHFQEQNDLKGLLDNLHQNIQAKKRKNVEIMWLAATICRKLNGIRFTCCKSAKDRTSMSVTLEQCSILRDEHQLHKDFFIRALDCMRREGCRIENVLKNIKCRRYAFNMLQLMAFPKCYRPPEGTYGKADT", "length": 928 }, "evidence": [ { "id": "A0A1D5PYC2", "url": "https://omabrowser.org/oma/group/A0A1D5PYC2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity", "id": "GO:0016316", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016316", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PYC2", "url": "https://www.uniprot.org/uniprot/A0A1D5PYC2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PYC2", "url": "https://www.uniprot.org/uniprot/A0A1D5PYC2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 923, "end_pos": 925, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "43388", "name": "", "equation": "1D-myo-inositol 3,4-bisphosphate + H2O = 1D-myo-inositol 3-phosphate + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A1D5PYC2-1" ], "evidence": [ { "id": "43388", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/43388" } ] }, { "id": "R-GGA-1676162", "name": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, early endosome membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A1D5PYC2-1" ], "evidence": [ { "id": "R-GGA-1676162", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-1676162" } ] }, { "id": "R-GGA-1676164", "name": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A1D5PYC2-1" ], "evidence": [ { "id": "R-GGA-1676164", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-1676164" } ] }, { "id": "R-GGA-1855180", "name": "I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [ "R-ALL-1629769" ], "enzyme_list": [ "A0A1D5PYC2-1" ], "evidence": [ { "id": "R-GGA-1855180", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-1855180" } ] }, { "id": "R-GGA-1855202", "name": "I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-1629746" ], "output_participant_list": [], "enzyme_list": [ "A0A1D5PYC2-1" ], "evidence": [ { "id": "R-GGA-1855202", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-1855202" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-1629746", "participant_name": "I(3,4)P2 [cytosol]", "crossref": [ { "id": "HMDB0006235", "database": "HMDB Metabolite", "url": "" }, { "id": "C04063", "database": "COMPOUND", "url": "" }, { "id": "28858", "database": "ChEBI", "url": "" }, { "id": "000004096300", "database": "ZINC", "url": "" } ] }, { "participant_id": "R-ALL-1629769", "participant_name": "I(1,3)P2 [cytosol]", "crossref": [ { "id": "C04062", "database": "COMPOUND", "url": "" }, { "id": "18225", "database": "ChEBI", "url": "" }, { "id": "000100016181", "database": "ZINC", "url": "" }, { "id": "HMDB0006234", "database": "HMDB Metabolite", "url": "" }, { "id": "5099", "database": "Guide to Pharmacology - Ligands", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A1D5PYC2", "gene_name": "INPP4B", "activity": [ { "ec_number": "3.1.3.66", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate.", "evidence": [ { "id": "A0A1D5PYC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A1D5PYC2" } ] }, { "ec_number": "3.1.3.66", "activity": "", "evidence": [ { "id": "A0A1D5PYC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A1D5PYC2" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A1D5PYC2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 972, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A1D5PYC2-F1.pdb" } ], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.1.3.66", "ec_name": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate.", "evidence": [ { "id": "3.1.3.66", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.66" }, { "id": "3.1.3.66", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.3.66" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 923, "end_pos": 925 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }