{
    "uniprot_canonical_ac": "A0A1D5PR34-1",
    "uniprot_ac": "A0A1D5PR34",
    "uniprot_id": "A0A1D5PR34_CHICK",
    "mass": {
        "chemical_mass": 17447.0,
        "monoisotopic_mass": 17447.0
    },
    "refseq": {
        "ac": "XP_001231893",
        "name": "ORM1-like protein 1",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001231893"
    },
    "gene_names": [
        {
            "name": "ORMDL1",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A0A1D5PR34",
            "id": "A0A1D5PR34"
        },
        {
            "name": "ORMDL1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001231893",
            "id": "XP_001231893"
        }
    ],
    "protein_names": [
        {
            "name": "ORM1-like protein",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprotkb/A0A1D5PR34/entry#names_and_taxonomy",
            "id": "A0A1D5PR34"
        },
        {
            "name": "ORM1-like protein 1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001231893",
            "id": "XP_001231893"
        }
    ],
    "function": [
        {
            "annotation": "##Genome-Annotation-Data-START## Annotation Provider         :: NCBI Annotation Status           :: Full annotation Annotation Name             :: Gallus gallus Annotation Release 106 Annotation Version          :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method           :: Best-placed RefSeq; Gnomon Features Annotated          :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## ##RefSeq-Attributes-START## ab initio                   :: 3% of CDS bases ##RefSeq-Attributes-END## MODEL REFSEQ:  This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052538.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "XP_001231893",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001231893"
                }
            ]
        },
        {
            "annotation": "Plays an essential role in the homeostatic regulation of sphingolipid de novo biosynthesis by modulating the activity of the serine palmitoyltransferase (SPT) in response to ceramide levels. When complexed to SPT, the binding of ceramides to its N-terminus stabilizes a conformation that block SPT substrate entry, hence preventing SPT catalytic activity.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A1D5PR34",
                    "url": "https://www.uniprot.org/uniprot/A0A1D5PR34#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "PIRNR018147",
                    "url": "https://www.uniprot.org/uniprot/PIRNR018147#function"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Gallus gallus",
            "taxid": 9031,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A1D5PR34",
                    "url": "https://www.uniprot.org/uniprot/A0A1D5PR34"
                }
            ],
            "common_name": "Chicken",
            "glygen_name": "Chicken",
            "reference_species": "Gallus gallus [9031]"
        }
    ],
    "gene": [
        {
            "name": "ORMDL1",
            "url": "https://www.uniprot.org/uniprot/A0A1D5PR34",
            "locus": {
                "chromosome": "7",
                "start_pos": 393187,
                "end_pos": 387390,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSGALG00010012892",
                        "url": "https://www.ensembl.org/id/ENSGALG00010012892"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "A0A1D5PR34",
            "url": "https://alphafold.ebi.ac.uk/entry/A0A1D5PR34",
            "database": "AlphaFoldDB",
            "categories": []
        },
        {
            "id": "ENSGALG00000036257",
            "url": "https://bgee.org/?page=gene&gene_id=ENSGALG00000036257",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "423981",
            "url": "https://www.ncbi.nlm.nih.gov/gene/423981",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR007203",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR007203",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "gga:423981",
            "url": "https://www.genome.jp/dbget-bin/www_bget?gga:423981",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "YKGAWII",
            "url": "https://omabrowser.org/oma/group/YKGAWII/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "A0A1D5PR34",
            "url": "https://www.orthodb.org/?gene=A0A1D5PR34",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR12665",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12665",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR12665:SF12",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12665:SF12",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF04061",
            "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04061",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "XP_001231893",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001231893",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A1D5PR34",
            "url": "https://www.uniprot.org/uniprot/A0A1D5PR34",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A1D5PR34-1",
            "url": "https://www.uniprot.org/uniprot/A0A1D5PR34-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MNVGVAHSEVNPNTRVMNSRGMWLTYTLGVGLLHIVLLSIPFFSVPVAWTLTNVIHNLGMYVFLHAVKGTPFETPDQGKARLLTHWEQLDYGVQFTSSRKFFTISPIILYFLASFYTKYDPTHFIFNTTSLLTVLIPKLPQLHGVRIFGINKY",
        "length": 153,
        "header": "tr|A0A1D5PR34-1|A0A1D5PR34_CHICK Isoform 1 of ORM1-like protein  OS=Gallus gallus OX=9031 GN=ORMDL1 PE=3 SV=1 CANONICAL=A0A1D5PR34-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A1D5PR34-1",
            "url": "https://www.uniprot.org/uniprotkb/A0A1D5PR34/entry#A0A1D5PR34-1",
            "sequence": {
                "sequence": "MNVGVAHSEVNPNTRVMNSRGMWLTYTLGVGLLHIVLLSIPFFSVPVAWTLTNVIHNLGMYVFLHAVKGTPFETPDQGKARLLTHWEQLDYGVQFTSSRKFFTISPIILYFLASFYTKYDPTHFIFNTTSLLTVLIPKLPQLHGVRIFGINKY",
                "length": 153,
                "header": "tr|A0A1D5PR34-1|A0A1D5PR34_CHICK Isoform 1 of ORM1-like protein  OS=Gallus gallus OX=9031 GN=ORMDL1 PE=3 SV=1 CANONICAL=A0A1D5PR34-1"
            },
            "locus": {
                "chromosome": "7",
                "start_pos": 392897,
                "end_pos": 389464,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSGALT00010030931.1",
                        "url": "https://www.ensembl.org/id/ENSGALT00010030931.1"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSGALP00010017966.1",
                        "url": "https://www.ensembl.org/id/ENSGALP00010017966.1"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [],
    "pathway": [
        {
            "id": "gga:423981",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/www_bget?gga:423981",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "F1RXU4-1",
            "protein_name": "ORM1-like protein",
            "gene_name": "ORMDL1",
            "tax_id": 9823,
            "organism": "Sus scrofa",
            "sequence": {
                "sequence": "MNVGVAHSEVNPNTRVMNSRGMWLTYALGVGLLHIVLLSIPFFSVPVAWTLTNVIHNLGMYVFLHAVKGTPFETPDQGKARLLTHWEQLDYGVQFTSSRKFFTISPIILYFLASFYTKYDPTHFILNTASLLSVLIPKMPQLHGVRIFGINKY",
                "length": 153
            },
            "evidence": [
                {
                    "id": "A0A1D5PR34",
                    "url": "https://omabrowser.org/oma/group/A0A1D5PR34/",
                    "database": "OMA"
                }
            ],
            "glygen_name": "Pig",
            "common_name": "Pig"
        },
        {
            "uniprot_canonical_ac": "Q06144-1",
            "protein_name": "Protein ORM2",
            "gene_name": "ORM2",
            "tax_id": 559292,
            "organism": "Saccharomyces cerevisiae S288C",
            "sequence": {
                "sequence": "MIDRTKNESPAFEESPLTPNVSNLKPFPSQSNKISTPVTDHRRRRSSSVISHVEQETFEDENDQQMLPNMNATWVDQRGAWLIHIVVIVLLRLFYSLFGSTPKWTWTLTNMTYIIGFYIMFHLVKGTPFDFNGGAYDNLTMWEQINDETLYTPTRKFLLIVPIVLFLISNQYYRNDMTLFLSNLAVTVLIGVVPKLGITHRLRISIPGITGRAQIS",
                "length": 216
            },
            "evidence": [
                {
                    "id": "A0A1D5PR34",
                    "url": "https://omabrowser.org/oma/group/A0A1D5PR34/",
                    "database": "OMA"
                }
            ],
            "glygen_name": "Yeast",
            "common_name": "Baker's yeast"
        },
        {
            "uniprot_canonical_ac": "Q29RQ9-1",
            "protein_name": "ORM1-like protein 1",
            "gene_name": "ORMDL1",
            "tax_id": 9913,
            "organism": "Bos taurus",
            "sequence": {
                "sequence": "MNVGVAHSEVNPNTRVMNSRGMWLTYALGVGLLHIVLLSIPFFSVPVAWTLTNVIHNLGMYVFLHAVKGTPFETPDQGKARLLTHWEQLDYGVQFTSSRKFFTISPIILYFLASFYTKYDTTHFILNTASLLSVLIPKMPQLHGVRIFGINKY",
                "length": 153
            },
            "evidence": [
                {
                    "id": "A0A1D5PR34",
                    "url": "https://omabrowser.org/oma/group/A0A1D5PR34/",
                    "database": "OMA"
                }
            ],
            "glygen_name": "Bovine",
            "common_name": "Bovine"
        },
        {
            "uniprot_canonical_ac": "Q921I0-1",
            "protein_name": "ORM1-like protein 1",
            "gene_name": "Ormdl1",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MNVGVAHSEVNPNTRVMNSRGMWLTYALGVGLLHIVLLSIPFCSVPVAWTLTNIIHNLGMYVFLHAVKGTPFETPDQGRARLLTHWEQLDYGVQFTSSRKFFTISPIILYFLASFYTKYDPTHFILNTASLLSVLIPKMPQLHGVRIFGINKY",
                "length": 153
            },
            "evidence": [
                {
                    "id": "A0A1D5PR34",
                    "url": "https://omabrowser.org/oma/group/A0A1D5PR34/",
                    "database": "OMA"
                }
            ],
            "glygen_name": "Mouse",
            "common_name": "Mouse"
        },
        {
            "uniprot_canonical_ac": "Q9FHY3-1",
            "protein_name": "At5g42000",
            "gene_name": "ATORM2",
            "tax_id": 3702,
            "organism": "Arabidopsis thaliana",
            "sequence": {
                "sequence": "MYVRALPTTDVNRNTEWFTYPGVWTTYILILFFSWLLVLSVFHCSPGIAWTIVHLAHFTVTYHSFHWKKGTPFGDDQGVYNRLTWWEQIDNGKQLTRNRKFLTVVPVVLYLIASHTTDYQHPMLFLNTLAVFVMVVAKFPHMHKVRIFGINGDQ",
                "length": 154
            },
            "evidence": [
                {
                    "id": "A0A1D5PR34",
                    "url": "https://omabrowser.org/oma/group/A0A1D5PR34/",
                    "database": "OMA"
                }
            ],
            "glygen_name": "Arabidopsis",
            "common_name": "Mouse-ear cress"
        },
        {
            "uniprot_canonical_ac": "Q9P0S3-1",
            "protein_name": "ORM1-like protein 1",
            "gene_name": "ORMDL1",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MNVGVAHSEVNPNTRVMNSRGMWLTYALGVGLLHIVLLSIPFFSVPVAWTLTNIIHNLGMYVFLHAVKGTPFETPDQGKARLLTHWEQLDYGVQFTSSRKFFTISPIILYFLASFYTKYDPTHFILNTASLLSVLIPKMPQLHGVRIFGINKY",
                "length": 153
            },
            "evidence": [
                {
                    "id": "A0A1D5PR34",
                    "url": "https://omabrowser.org/oma/group/A0A1D5PR34/",
                    "database": "OMA"
                }
            ],
            "glygen_name": "Human",
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Biological Process",
                "total": 5,
                "go_terms": [
                    {
                        "name": "sphingomyelin biosynthetic process",
                        "id": "GO:0006686",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006686",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1D5PR34",
                                "url": "https://www.uniprot.org/uniprot/A0A1D5PR34"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "negative regulation of ceramide biosynthetic process",
                        "id": "GO:1900060",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900060",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1D5PR34",
                                "url": "https://www.uniprot.org/uniprot/A0A1D5PR34"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "myelination",
                        "id": "GO:0042552",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042552",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1D5PR34",
                                "url": "https://www.uniprot.org/uniprot/A0A1D5PR34"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "ceramide metabolic process",
                        "id": "GO:0006672",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006672",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1D5PR34",
                                "url": "https://www.uniprot.org/uniprot/A0A1D5PR34"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "motor behavior",
                        "id": "GO:0061744",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061744",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1D5PR34",
                                "url": "https://www.uniprot.org/uniprot/A0A1D5PR34"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 1,
                "go_terms": [
                    {
                        "name": "endoplasmic reticulum membrane",
                        "id": "GO:0005789",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1D5PR34",
                                "url": "https://www.uniprot.org/uniprot/A0A1D5PR34"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 127,
            "end_pos": 129,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "biomarkers": [],
    "structures": [
        {
            "pdb_id": "AF-A0A1D5PR34-F1",
            "pdb_chain": "global",
            "start_pos": 1,
            "end_pos": 153,
            "overlap": "1.0",
            "method": "AlphaFold",
            "type": "alphafold",
            "resolution": -1.0,
            "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A1D5PR34-F1.pdb"
        }
    ],
    "synthesized_glycans": [],
    "enzyme_annotation": [],
    "cluster_types": [
        {
            "name": "homologset.oma",
            "label": "OMA Homologs"
        }
    ],
    "sequence_features": {
        "n_linked_sites": [],
        "o_linked_sites": [],
        "snv_sites": [],
        "glycation_sites": [],
        "phosphorylation_sites": [],
        "sequon_annotation_sites": [
            {
                "start_pos": 127,
                "end_pos": 129
            }
        ]
    },
    "section_stats": [
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}