{ "uniprot_canonical_ac": "A0A1D5PMI2-1", "uniprot_ac": "A0A1D5PMI2", "uniprot_id": "A0A1D5PMI2_CHICK", "mass": { "chemical_mass": 87412.0, "monoisotopic_mass": 87412.0 }, "refseq": {}, "gene_names": [ { "name": "BCL11A", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A1D5PMI2", "id": "A0A1D5PMI2" } ], "protein_names": [ { "name": "B-cell CLL/lymphoma 11A", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PMI2/entry#names_and_taxonomy", "id": "A0A1D5PMI2" } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Gallus gallus", "taxid": 9031, "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PMI2", "url": "https://www.uniprot.org/uniprot/A0A1D5PMI2" } ], "common_name": "Chicken", "glygen_name": "Chicken", "reference_species": "Gallus gallus [9031]" } ], "gene": [ { "name": "BCL11A", "url": "https://www.uniprot.org/uniprot/A0A1D5PMI2", "locus": { "chromosome": "3", "start_pos": 1930777, "end_pos": 1991462, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSGALG00010017162", "url": "https://www.ensembl.org/id/ENSGALG00010017162" } ] } } ], "crossref": [ { "id": "A0A1D5PMI2", "url": "https://alphafold.ebi.ac.uk/entry/A0A1D5PMI2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSGALG00000034048", "url": "https://bgee.org/?page=gene&gene_id=ENSGALG00000034048", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051497", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051497", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR45993", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45993", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45993:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45993:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "A0A1D5PMI2", "url": "https://www.uniprot.org/uniprot/A0A1D5PMI2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1D5PMI2-1", "url": "https://www.uniprot.org/uniprot/A0A1D5PMI2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSRRKQGKPQHLSKREFSPEPLEAILTDDEPDHSTLGAPEGDHDLLTCGQCQMNFPLGDILIFIEHKRKQCNGSLCLEKAVDKPPSPSPSELKKASNPVEVGIQVTPEDDDCLSTSSRGICPKQEHIAGKEEPSSYTCTTCKQPFNSAWFLLQHAQNTHGLRIYLESEHGSPLTPRVGIPSGLGAECPSQPPLHGIHIADNNPFNLLRIPGSVSREASGLGEGRFPPTPPLFSPPPRHHLDPHRIERLGAEEMALATHHPSAFDRVLRLNPMAMEPPAMDFSRRLRELAGNTSSPPLSPSRPSPMQRLLQPFQPGSKPPFLATPPLPPLQSAPPPSQPPMKSKSCEFCGKTFKFQSNLVVHRRSHTGEKPYKCNLCDHACTQASKLKRHMKTHMHKSSPMTVKSDDGLSTASSPEPGTSDLVGSASSALKSVVAKFKSENDPNMIPENGDEEEEEEEEEEEEEEEEEEEDLTENERPDYGFGMNLEAAHHHENNSRAGEESRSMPDVMQGMVLSSMQHFSEAFHQVLGEKHKRGHLSEAEVHRDTCDEDSVAGESDRIDDGAVNGRGCSPGESASGGLSKKLLLGSPSSLSPFSKRIKLEKEFDLPATAMPNTENVYSQWLAGYAASRQLKDPFLSFGDSRQSPFASSSEHSSENGSLRFSTPPGELDGGISGRSGTGSGGSTPHISGPGPGRPSSKEGRRSDTCEYCGKVFKNCSNLTVHRRSHTGERPYKCELCNYACAQSSKLTRHMKTHGQVGKDVYKCEICKMPFSVYSTLEKHMKKWHSDRVLNNEIKTE", "length": 796, "header": "tr|A0A1D5PMI2-1|A0A1D5PMI2_CHICK Isoform 1 of B-cell CLL/lymphoma 11A OS=Gallus gallus OX=9031 GN=BCL11A PE=4 SV=1 CANONICAL=A0A1D5PMI2-1" }, "isoforms": [ { "isoform_ac": "A0A1D5PMI2-1", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PMI2/entry#A0A1D5PMI2-1", "sequence": { "sequence": "MSRRKQGKPQHLSKREFSPEPLEAILTDDEPDHSTLGAPEGDHDLLTCGQCQMNFPLGDILIFIEHKRKQCNGSLCLEKAVDKPPSPSPSELKKASNPVEVGIQVTPEDDDCLSTSSRGICPKQEHIAGKEEPSSYTCTTCKQPFNSAWFLLQHAQNTHGLRIYLESEHGSPLTPRVGIPSGLGAECPSQPPLHGIHIADNNPFNLLRIPGSVSREASGLGEGRFPPTPPLFSPPPRHHLDPHRIERLGAEEMALATHHPSAFDRVLRLNPMAMEPPAMDFSRRLRELAGNTSSPPLSPSRPSPMQRLLQPFQPGSKPPFLATPPLPPLQSAPPPSQPPMKSKSCEFCGKTFKFQSNLVVHRRSHTGEKPYKCNLCDHACTQASKLKRHMKTHMHKSSPMTVKSDDGLSTASSPEPGTSDLVGSASSALKSVVAKFKSENDPNMIPENGDEEEEEEEEEEEEEEEEEEEDLTENERPDYGFGMNLEAAHHHENNSRAGEESRSMPDVMQGMVLSSMQHFSEAFHQVLGEKHKRGHLSEAEVHRDTCDEDSVAGESDRIDDGAVNGRGCSPGESASGGLSKKLLLGSPSSLSPFSKRIKLEKEFDLPATAMPNTENVYSQWLAGYAASRQLKDPFLSFGDSRQSPFASSSEHSSENGSLRFSTPPGELDGGISGRSGTGSGGSTPHISGPGPGRPSSKEGRRSDTCEYCGKVFKNCSNLTVHRRSHTGERPYKCELCNYACAQSSKLTRHMKTHGQVGKDVYKCEICKMPFSVYSTLEKHMKKWHSDRVLNNEIKTE", "length": 796, "header": "tr|A0A1D5PMI2-1|A0A1D5PMI2_CHICK Isoform 1 of B-cell CLL/lymphoma 11A OS=Gallus gallus OX=9031 GN=BCL11A PE=4 SV=1 CANONICAL=A0A1D5PMI2-1" }, "locus": { "chromosome": "3", "start_pos": 1991130, "end_pos": 1938413, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSGALT00010041405.1", "url": "https://www.ensembl.org/id/ENSGALT00010041405.1" }, { "database": "Ensembl Peptide", "id": "ENSGALP00010024257.1", "url": "https://www.ensembl.org/id/ENSGALP00010024257.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool": "isoglyp", "mining_tool": "", "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "start_pos": 228, "start_aa": "T", "end_pos": 228, "end_aa": "T", "residue": "Thr", "site_lbl": "Thr228", "evidence": [ { "id": "GLY_001161", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001161" } ], "filter_code": "00000000000000001000.00000000001000.1.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool": "isoglyp", "mining_tool": "", "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "start_pos": 323, "start_aa": "T", "end_pos": 323, "end_aa": "T", "residue": "Thr", "site_lbl": "Thr323", "evidence": [ { "id": "GLY_001161", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001161" } ], "filter_code": "00000000000000001000.00000000001000.1.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PMI2", "url": "https://www.uniprot.org/uniprot/A0A1D5PMI2" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PMI2", "url": "https://www.uniprot.org/uniprot/A0A1D5PMI2" } ], "pmid": "" }, { "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PMI2", "url": "https://www.uniprot.org/uniprot/A0A1D5PMI2" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PMI2", "url": "https://www.uniprot.org/uniprot/A0A1D5PMI2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PMI2", "url": "https://www.uniprot.org/uniprot/A0A1D5PMI2" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PMI2", "url": "https://www.uniprot.org/uniprot/A0A1D5PMI2" } ], "pmid": "" }, { "name": "SWI/SNF complex", "id": "GO:0016514", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016514", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PMI2", "url": "https://www.uniprot.org/uniprot/A0A1D5PMI2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PMI2", "url": "https://www.uniprot.org/uniprot/A0A1D5PMI2" } ], "pmid": "" }, { "name": "negative regulation of dendrite development", "id": "GO:2000171", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000171", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PMI2", "url": "https://www.uniprot.org/uniprot/A0A1D5PMI2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 291, "end_pos": 293, "annotation": "n_glycosylation_sequon" }, { "start_pos": 493, "end_pos": 495, "annotation": "n_glycosylation_sequon" }, { "start_pos": 655, "end_pos": 657, "annotation": "n_glycosylation_sequon" }, { "start_pos": 714, "end_pos": 716, "annotation": "n_glycosylation_sequon" }, { "start_pos": 717, "end_pos": 719, "annotation": "n_glycosylation_sequon" }, { "start_pos": 72, "end_pos": 74, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A1D5PMI2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 796, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A1D5PMI2-F1.pdb" } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 228, 323 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 291, "end_pos": 293 }, { "start_pos": 493, "end_pos": 495 }, { "start_pos": 655, "end_pos": 657 }, { "start_pos": 714, "end_pos": 716 }, { "start_pos": 717, "end_pos": 719 }, { "start_pos": 72, "end_pos": 74 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 2 } ], 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