{ "uniprot_canonical_ac": "A0A1D5PLJ0-1", "uniprot_ac": "A0A1D5PLJ0", "uniprot_id": "A0A1D5PLJ0_CHICK", "mass": { "chemical_mass": 44900.0, "monoisotopic_mass": 44900.0 }, "refseq": { "ac": "NP_001026067", "name": "ras-related GTP-binding protein C", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026067" }, "gene_names": [ { "name": "RRAGC", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A1D5PLJ0", "id": "A0A1D5PLJ0" }, { "name": "RCJMB04_5g2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A1D5PLJ0", "id": "A0A1D5PLJ0" }, { "name": "RRAGC", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026067", "id": "NP_001026067" } ], "protein_names": [ { "name": "Ras-related GTP-binding protein", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PLJ0/entry#names_and_taxonomy", "id": "A0A1D5PLJ0" }, { "name": "ras-related GTP-binding protein C", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026067", "id": "NP_001026067" } ], "function": [ { "annotation": "##Evidence-Data-START## Transcript exon combination :: AJ719695.1, HAEK01076756.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000339.1. On Aug 8, 2005 this sequence version replaced XP_417752.1.", "evidence": [ { "database": "RefSeq", "id": "NP_001026067", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026067" } ] }, { "annotation": "Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PLJ0", "url": "https://www.uniprot.org/uniprot/A0A1D5PLJ0#function" }, { "database": "UniProtKB", "id": "RU367014", "url": "https://www.uniprot.org/uniprot/RU367014#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Gallus gallus", "taxid": 9031, "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PLJ0", "url": "https://www.uniprot.org/uniprot/A0A1D5PLJ0" } ], "common_name": "Chicken", "glygen_name": "Chicken", "reference_species": "Gallus gallus [9031]" } ], "gene": [ { "name": "RRAGC", "url": "https://www.uniprot.org/uniprot/A0A1D5PLJ0", "locus": { "chromosome": "23", "start_pos": 3634385, "end_pos": 3625577, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSGALG00010013645", "url": "https://www.ensembl.org/id/ENSGALG00010013645" } ] } } ], "crossref": [ { "id": "ENSGALG00000033079", "url": "https://bgee.org/?page=gene&gene_id=ENSGALG00000033079", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd11385", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11385", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "419605", "url": "https://www.ncbi.nlm.nih.gov/gene/419605", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006762", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006762", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039400", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039400", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "gga:419605", "url": "https://www.genome.jp/dbget-bin/www_bget?gga:419605", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ICNHQAS", "url": "https://omabrowser.org/oma/group/ICNHQAS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A1D5PLJ0", "url": "https://www.orthodb.org/?gene=A0A1D5PLJ0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11259", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11259", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11259:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11259:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04670", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04670", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "R-GGA-1632852", "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-1632852", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-GGA-165159", "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-165159", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-GGA-166208", "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-166208", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-GGA-380972", "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-380972", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-GGA-5628897", "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-5628897", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-GGA-8943724", "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-8943724", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-GGA-9639288", "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-9639288", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001026067", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026067", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "19669", "url": "https://www.rhea-db.org/rhea/19669", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A1D5PLJ0", "url": "https://www.uniprot.org/uniprot/A0A1D5PLJ0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1D5PLJ0-1", "url": "https://www.uniprot.org/uniprot/A0A1D5PLJ0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALQFGGAGAAGAAEEPALVGGSFGAADSFPKDFGYGEEEEEAELEGGPGPGGPGGGAGGPGGGAGGADSKPRILLMGLRRSGKSSIQKVVFHKMSPNETLFLESTNKIYKDDISNSSFVNFQIWDFPGQMDFFDPTFDYEMIFRGTGALIYVIDAQDDYMEALTRLHITVSKAYKVNPEMNFEVFIHKVDGLSDDHKIETQRDIHQRANDDLTDAGLEKLHLSFYLTSIYDHSIFEAFSKVVQKLIPQLPTLENLLNIFISNSGIEKAFLFDVVSKIYIATDSSPVDMQSYELCCDMIDVVIDVSCIYGLKEDGTGSAYDKESMAIIKLNNTTVLYLKEVTKFLALVCILREESFERKGLIDYNFHCFRKAIHEVFEVGVASHRICNHQASASSLKAVTHNGTPRNAV", "length": 409, "header": "tr|A0A1D5PLJ0-1|A0A1D5PLJ0_CHICK Isoform 1 of Ras-related GTP-binding protein OS=Gallus gallus OX=9031 GN=RRAGC PE=1 SV=2 CANONICAL=A0A1D5PLJ0-1" }, "isoforms": [ { "isoform_ac": "A0A1D5PLJ0-1", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PLJ0/entry#A0A1D5PLJ0-1", "sequence": { "sequence": "MALQFGGAGAAGAAEEPALVGGSFGAADSFPKDFGYGEEEEEAELEGGPGPGGPGGGAGGPGGGAGGADSKPRILLMGLRRSGKSSIQKVVFHKMSPNETLFLESTNKIYKDDISNSSFVNFQIWDFPGQMDFFDPTFDYEMIFRGTGALIYVIDAQDDYMEALTRLHITVSKAYKVNPEMNFEVFIHKVDGLSDDHKIETQRDIHQRANDDLTDAGLEKLHLSFYLTSIYDHSIFEAFSKVVQKLIPQLPTLENLLNIFISNSGIEKAFLFDVVSKIYIATDSSPVDMQSYELCCDMIDVVIDVSCIYGLKEDGTGSAYDKESMAIIKLNNTTVLYLKEVTKFLALVCILREESFERKGLIDYNFHCFRKAIHEVFEVGVASHRICNHQASASSLKAVTHNGTPRNAV", "length": 409, "header": "tr|A0A1D5PLJ0-1|A0A1D5PLJ0_CHICK Isoform 1 of Ras-related GTP-binding protein OS=Gallus gallus OX=9031 GN=RRAGC PE=1 SV=2 CANONICAL=A0A1D5PLJ0-1" }, "locus": { "chromosome": "23", "start_pos": 3632556, "end_pos": 3625602, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSGALT00010032804.1", "url": "https://www.ensembl.org/id/ENSGALT00010032804.1" }, { "database": "Ensembl Peptide", "id": "ENSGALP00010019430.1", "url": "https://www.ensembl.org/id/ENSGALP00010019430.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis.", "journal": "Genome Biol.", "date": "2005", "authors": "Caldwell Randolph B, Kierzek Andrzej M, Arakawa Hiroshi, Bezzubov Yuri, Zaim Jolanta, Fiedler Petra, Kutter Stefan, Blagodatski Artem, Kostovska Diyana, Koter Marek, Plachy Jiri, Carninci Piero, Hayashizaki Yoshihide, Buerstedde Jean-Marie", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PLJ0", "url": "https://www.uniprot.org/uniprot/A0A1D5PLJ0" } ], "reference": [ { "type": "PubMed", "id": "15642098", "url": "https://glygen.org/publication/PubMed/15642098" } ] } ], "pathway": [ { "id": "gga:419605", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?gga:419605", "resource": "KEGG Pathway" }, { "id": "R-GGA-1632852", "name": "Macroautophagy", "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-1632852", "resource": "Reactome", "description": "Macroautophagy" }, { "id": "R-GGA-165159", "name": "MTOR signalling", "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-165159", "resource": "Reactome", "description": "MTOR signalling" }, { "id": "R-GGA-166208", "name": "mTORC1-mediated signalling", "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-166208", "resource": "Reactome", "description": "mTORC1-mediated signalling" }, { "id": "R-GGA-380972", "name": "Energy dependent regulation of mTOR by LKB1-AMPK", "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-380972", "resource": "Reactome", "description": "Energy dependent regulation of mTOR by LKB1-AMPK" }, { "id": "R-GGA-5628897", "name": "TP53 Regulates Metabolic Genes", "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-5628897", "resource": "Reactome", "description": "TP53 Regulates Metabolic Genes" }, { "id": "R-GGA-8943724", "name": "Regulation of PTEN gene transcription", "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-8943724", "resource": "Reactome", "description": "Regulation of PTEN gene transcription" }, { "id": "R-GGA-9639288", "name": "Amino acids regulate mTORC1", "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-9639288", "resource": "Reactome", "description": "Amino acids regulate mTORC1" } ], "orthologs": [ { "uniprot_canonical_ac": "Q0D2L6-1", "protein_name": "Ras-related GTP-binding protein", "gene_name": "Rragc", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSLQYGAEETPLAGSYGAADSFPKDFGYGVEEEEEEAAAGGGGGAGAGGGCGPGGGDSSKPRILLMGLRRSGKSSIQKVVFHKMSPNETLFLESTNKIYKDDISNSSFVNFQIWDFPGQMDFFDPTFDYEMIFRGTGALIYVIDAQDDYMEALTRLHITVSKAYKVNPDMNFEVFIHKVDGLSDDHKIETQRDIHQRANDDLADAGLEKLHLSFYLTSIYDHSIFEAFSKVVQKLIPQLPTLENLLNIFISNSGIEKAFLFDVVSKIYIATDSSPVDMQSYELCCDMIDVVIDVSCIYGLKEDGSGSAYDKESMAIIKLNNTTVLYLKEVTKFLALVCILREESFERKGLIDYNFHCFRKAIHEVFEVGVTSHRSCSHQTSAPSLKALAHNGTPRNAI", "length": 398 }, "evidence": [ { "id": "A0A1D5PLJ0", "url": "https://omabrowser.org/oma/group/A0A1D5PLJ0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q0VD29-1", "protein_name": "Ras-related GTP-binding protein", "gene_name": "RRAGC", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MSLQYGVEETPLAGSYGAADSFPKDFGYGVEEEEEEAAAAGGGVGAGAGGGCGPGGADSSKPRILLMGLRRSGKSSIQKVVFHKMSPNETLFLESTNKIYKDDISNSSFVNFQIWDFPGQMDFFDPTFDYEMIFRGTGALIYVIDAQDDYMEALTRLHITVSKAYKVNPDMNFEVFIHKVDGLSDDHKIETQRDIHQRANDDLADAGLEKLHLSFYLTSIYDHSIFEAFSKVVQKLIPQLPTLENLLNIFISNSGIEKAFLFDVVSKIYIATDSSPVDMQSYELCCDMIDVVIDVSCIYGLKEDGSGSAYDKESMAIIKLNNTTVLYLKEVTKFLALVCILREESFERKGLIDYNFHCFRKAIHEVFEVGVTSHRSCSHQTSAPSLKALTHNGTPRNAI", "length": 399 }, "evidence": [ { "id": "A0A1D5PLJ0", "url": "https://omabrowser.org/oma/group/A0A1D5PLJ0/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "Q99K70-1", "protein_name": "Ras-related GTP-binding protein C", "gene_name": "Rragc", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSLQYGAEETPLAGSYGAADSFPKDFGYGVEEEEEEAAAGGGGGAGAGGGCGPGGADSSKPRILLMGLRRSGKSSIQKVVFHKMSPNETLFLESTNKIYKDDISNSSFVNFQIWDFPGQMDFFDPTFDYEMIFRGTGALIYVIDAQDDYMEALTRLHITVSKAYKVNPDMNFEVFIHKVDGLSDDHKIETQRDIHQRANDDLADAGLEKLHLSFYLTSIYDHSIFEAFSKVVQKLIPQLPTLENLLNIFISNSGIEKAFLFDVVSKIYIATDSSPVDMQSYELCCDMIDVVIDVSCIYGLKEDGSGSAYDKESMAIIKLNNTTVLYLKEVTKFLALVCILREESFERKGLIDYNFHCFRKAIHEVFEVGVTSHRSCSHQTSAPSLKALAHNGTPRNAI", "length": 398 }, "evidence": [ { "id": "A0A1D5PLJ0", "url": "https://omabrowser.org/oma/group/A0A1D5PLJ0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9HB90-1", "protein_name": "Ras-related GTP-binding protein C", "gene_name": "RRAGC", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSLQYGAEETPLAGSYGAADSFPKDFGYGVEEEEEEAAAAGGGVGAGAGGGCGPGGADSSKPRILLMGLRRSGKSSIQKVVFHKMSPNETLFLESTNKIYKDDISNSSFVNFQIWDFPGQMDFFDPTFDYEMIFRGTGALIYVIDAQDDYMEALTRLHITVSKAYKVNPDMNFEVFIHKVDGLSDDHKIETQRDIHQRANDDLADAGLEKLHLSFYLTSIYDHSIFEAFSKVVQKLIPQLPTLENLLNIFISNSGIEKAFLFDVVSKIYIATDSSPVDMQSYELCCDMIDVVIDVSCIYGLKEDGSGSAYDKESMAIIKLNNTTVLYLKEVTKFLALVCILREESFERKGLIDYNFHCFRKAIHEVFEVGVTSHRSCGHQTSASSLKALTHNGTPRNAI", "length": 399 }, "evidence": [ { "id": "A0A1D5PLJ0", "url": "https://omabrowser.org/oma/group/A0A1D5PLJ0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "positive regulation of TORC1 signaling", "id": "GO:1904263", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904263", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PLJ0", "url": "https://www.uniprot.org/uniprot/A0A1D5PLJ0" } ], "pmid": "" }, { "name": "negative regulation of autophagy", "id": "GO:0010507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010507", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PLJ0", "url": "https://www.uniprot.org/uniprot/A0A1D5PLJ0" } ], "pmid": "" }, { "name": "protein localization to membrane", "id": "GO:0072657", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072657", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PLJ0", "url": "https://www.uniprot.org/uniprot/A0A1D5PLJ0" } ], "pmid": "" }, { "name": "cellular response to starvation", "id": "GO:0009267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009267", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PLJ0", "url": "https://www.uniprot.org/uniprot/A0A1D5PLJ0" } ], "pmid": "" }, { "name": "cellular response to amino acid starvation", "id": "GO:0034198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034198", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PLJ0", "url": "https://www.uniprot.org/uniprot/A0A1D5PLJ0" } ], "pmid": "" }, { "name": "cellular response to amino acid stimulus", "id": "GO:0071230", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071230", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PLJ0", "url": "https://www.uniprot.org/uniprot/A0A1D5PLJ0" } ], "pmid": "" }, { "name": "protein localization to lysosome", "id": "GO:0061462", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061462", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PLJ0", "url": "https://www.uniprot.org/uniprot/A0A1D5PLJ0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 7, "go_terms": [ { "name": "GTPase activity", "id": "GO:0003924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PLJ0", "url": "https://www.uniprot.org/uniprot/A0A1D5PLJ0" } ], "pmid": "" }, { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PLJ0", "url": "https://www.uniprot.org/uniprot/A0A1D5PLJ0" } ], "pmid": "" }, { "name": "protein heterodimerization activity", "id": "GO:0046982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046982", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PLJ0", "url": "https://www.uniprot.org/uniprot/A0A1D5PLJ0" } ], "pmid": "" }, { "name": "GTPase binding", "id": "GO:0051020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051020", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PLJ0", "url": "https://www.uniprot.org/uniprot/A0A1D5PLJ0" } ], "pmid": "" }, { "name": "protein-membrane adaptor activity", "id": "GO:0043495", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043495", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PLJ0", "url": "https://www.uniprot.org/uniprot/A0A1D5PLJ0" } ], "pmid": "" }, { "name": "GDP binding", "id": "GO:0019003", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019003", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PLJ0", "url": 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