{ "uniprot_canonical_ac": "A0A1D5PKA7-1", "uniprot_ac": "A0A1D5PKA7", "uniprot_id": "A0A1D5PKA7_CHICK", "mass": { "chemical_mass": 69377.0, "monoisotopic_mass": 69377.0 }, "refseq": { "ac": "NP_001186375", "name": "dachshund homolog 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186375" }, "gene_names": [ { "name": "DACH1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A1D5PKA7", "id": "A0A1D5PKA7" }, { "name": "DACH1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186375", "id": "NP_001186375" }, { "name": "DACH", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186375", "id": "NP_001186375" } ], "protein_names": [ { "name": "Dachshund family transcription factor 1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PKA7/entry#names_and_taxonomy", "id": "A0A1D5PKA7" }, { "name": "dachshund homolog 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186375", "id": "NP_001186375" } ], "function": [ { "annotation": "##Evidence-Data-START## Transcript exon combination :: SRR12888548.202011.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000027.1. On Dec 7, 2010 this sequence version replaced XP_417018.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments.", "evidence": [ { "database": "RefSeq", "id": "NP_001186375", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186375" } ] }, { "annotation": "Dach1 interacts with the Smad complex and Sin3a and has a role in controlling AER formation and limb development", "evidence": [ { "database": "RefSeq", "id": "NP_001186375", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186375" }, { "database": "PubMed", "id": "15280207", "url": "https://glygen.org/publication/PubMed/15280207" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Gallus gallus", "taxid": 9031, "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PKA7", "url": "https://www.uniprot.org/uniprot/A0A1D5PKA7" } ], "common_name": "Chicken", "glygen_name": "Chicken", "reference_species": "Gallus gallus [9031]" } ], "gene": [ { "name": "DACH1", "url": "https://www.uniprot.org/uniprot/A0A1D5PKA7", "locus": { "chromosome": "1", "start_pos": 156979403, "end_pos": 156610367, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSGALG00010000870", "url": "https://www.ensembl.org/id/ENSGALG00010000870" } ] } } ], "crossref": [ { "id": "A0A1D5PKA7", "url": "https://alphafold.ebi.ac.uk/entry/A0A1D5PKA7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSGALG00000037015", "url": "https://bgee.org/?page=gene&gene_id=ENSGALG00000037015", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd21081", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21081", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "373935", "url": "https://www.ncbi.nlm.nih.gov/gene/373935", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003380", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003380", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009061", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009061", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037000", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037000", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "gga:373935", "url": "https://www.genome.jp/dbget-bin/www_bget?gga:373935", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR12577", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12577", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12577:SF14", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12577:SF14", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02437", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02437", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "NP_001186375", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186375", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A1D5PKA7", "url": "https://www.uniprot.org/uniprot/A0A1D5PKA7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1D5PKA7-1", "url": "https://www.uniprot.org/uniprot/A0A1D5PKA7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAVPAALIPPAPLVPPQPPVSTSAACTTTTTTSSAAATSSPAPAIAPPPPASGTNLFRPEPIAAPAAAAATVTSTATTTTTGGSGGGGGSGGGGGSPSLGSGTGGGTSGTSTPNAGAAGSLPGKPVYSTPSPVENTPQNNECKMVDLRGAKVASFTVEGCELICLPQAFDLFLKHLVGGLHTVYTKLKRLEITPVVCNVEQVRILRGLGAIQPGVNRCKLISRKDFETLYNDCTNASSRPGRPPKRTQSVTSPENSHIMPHSVPGLMSPGIIPPTGLTAAAAAAAAATNAAIAEAMKVKKIKLEAMSNYHANNNQHGADSENGDLNSSVGLELPFMMMPHPLIPVSLPPASVTMAMSQMNHLSTIANMAAAAQVQSPPSRVETSVIKERVPDSPSPAPSLEEGRRPGSHPSSHRSSSVSSSPARTESSSDRIPVHQNGLSMNQMLMGLSPNVLPGPKEGDLAGHDMGHESKRIHIEKDETPLSTPTARDSLDKLSLTGHGQPLPPGFPSPFLFPDGLSSIETLLTNIQGLLKVAIDNARAQEKQVQLEKTELKMELFRERELRETLEKQLAVEQKNRAIIQKRLKKEKKAKRKLQEALEFETKRREQAEQTLKQAASTDSLRVLNDSLTPEIEADRSGGRTDAERTIQDGRLYLKTTVMY", "length": 660, "header": "tr|A0A1D5PKA7-1|A0A1D5PKA7_CHICK Isoform 1 of Dachshund family transcription factor 1 OS=Gallus gallus OX=9031 GN=DACH1 PE=3 SV=1 CANONICAL=A0A1D5PKA7-1" }, "isoforms": [ { "isoform_ac": "A0A1D5PKA7-1", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PKA7/entry#A0A1D5PKA7-1", "sequence": { "sequence": "MAVPAALIPPAPLVPPQPPVSTSAACTTTTTTSSAAATSSPAPAIAPPPPASGTNLFRPEPIAAPAAAAATVTSTATTTTTGGSGGGGGSGGGGGSPSLGSGTGGGTSGTSTPNAGAAGSLPGKPVYSTPSPVENTPQNNECKMVDLRGAKVASFTVEGCELICLPQAFDLFLKHLVGGLHTVYTKLKRLEITPVVCNVEQVRILRGLGAIQPGVNRCKLISRKDFETLYNDCTNASSRPGRPPKRTQSVTSPENSHIMPHSVPGLMSPGIIPPTGLTAAAAAAAAATNAAIAEAMKVKKIKLEAMSNYHANNNQHGADSENGDLNSSVGLELPFMMMPHPLIPVSLPPASVTMAMSQMNHLSTIANMAAAAQVQSPPSRVETSVIKERVPDSPSPAPSLEEGRRPGSHPSSHRSSSVSSSPARTESSSDRIPVHQNGLSMNQMLMGLSPNVLPGPKEGDLAGHDMGHESKRIHIEKDETPLSTPTARDSLDKLSLTGHGQPLPPGFPSPFLFPDGLSSIETLLTNIQGLLKVAIDNARAQEKQVQLEKTELKMELFRERELRETLEKQLAVEQKNRAIIQKRLKKEKKAKRKLQEALEFETKRREQAEQTLKQAASTDSLRVLNDSLTPEIEADRSGGRTDAERTIQDGRLYLKTTVMY", "length": 660, "header": "tr|A0A1D5PKA7-1|A0A1D5PKA7_CHICK Isoform 1 of Dachshund family transcription factor 1 OS=Gallus gallus OX=9031 GN=DACH1 PE=3 SV=1 CANONICAL=A0A1D5PKA7-1" }, "locus": { "chromosome": "1", "start_pos": 156976662, "end_pos": 156610599, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSGALT00010001903.1", "url": "https://www.ensembl.org/id/ENSGALT00010001903.1" }, { "database": "Ensembl Peptide", "id": "ENSGALP00010001045.1", "url": "https://www.ensembl.org/id/ENSGALP00010001045.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool": "isoglyp", "mining_tool": "", "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "start_pos": 129, "start_aa": "T", "end_pos": 129, "end_aa": "T", "residue": "Thr", "site_lbl": "Thr129", "evidence": [ { "id": "GLY_001161", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001161" } ], "filter_code": "00000000000000001000.00000000001000.1.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Chick Dach1 interacts with the Smad complex and Sin3a to control AER formation and limb development along the proximodistal axis.", "journal": "Development (Cambridge, England)", "date": "2004-09", "authors": "Kida Yasuyuki, Maeda Yukiko, Shiraishi Tomoki, Suzuki Takayuki, Ogura Toshihiko", "evidence": [ { "database": "RefSeq", "id": "NP_001186375", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186375" } ], "reference": [ { "type": "PubMed", "id": "15280207", "url": "https://glygen.org/publication/PubMed/15280207" } ] } ], "pathway": [ { "id": "gga:373935", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?gga:373935", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 9, "go_terms": [ { "name": "regulation of nuclear cell cycle DNA replication", "id": "GO:0033262", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033262", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PKA7", "url": "https://www.uniprot.org/uniprot/A0A1D5PKA7" } ], "pmid": "" }, { "name": "negative regulation of cell proliferation involved in contact inhibition", "id": "GO:0060244", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060244", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PKA7", "url": "https://www.uniprot.org/uniprot/A0A1D5PKA7" } ], "pmid": "" }, { "name": "respiratory gaseous exchange by respiratory system", "id": "GO:0007585", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007585", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PKA7", "url": "https://www.uniprot.org/uniprot/A0A1D5PKA7" } ], "pmid": "" }, { "name": "negative regulation of cell migration", "id": "GO:0030336", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030336", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PKA7", "url": "https://www.uniprot.org/uniprot/A0A1D5PKA7" } ], "pmid": "" }, { "name": "negative regulation of fibroblast proliferation", "id": "GO:0048147", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048147", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PKA7", "url": "https://www.uniprot.org/uniprot/A0A1D5PKA7" } ], "pmid": "" }, { "name": "development of primary female sexual characteristics", "id": "GO:0046545", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046545", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PKA7", "url": "https://www.uniprot.org/uniprot/A0A1D5PKA7" } ], "pmid": "" }, { "name": "negative regulation of DNA biosynthetic process", "id": "GO:2000279", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000279", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PKA7", "url": "https://www.uniprot.org/uniprot/A0A1D5PKA7" } ], "pmid": "" }, { "name": "negative regulation of transcription by competitive promoter binding", "id": "GO:0010944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010944", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PKA7", "url": "https://www.uniprot.org/uniprot/A0A1D5PKA7" } ], "pmid": "" }, { "name": "type B pancreatic cell proliferation", "id": "GO:0044342", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044342", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PKA7", "url": "https://www.uniprot.org/uniprot/A0A1D5PKA7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PKA7", "url": "https://www.uniprot.org/uniprot/A0A1D5PKA7" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PKA7", "url": "https://www.uniprot.org/uniprot/A0A1D5PKA7" } ], "pmid": "" }, { "name": "nuclear speck", "id": "GO:0016607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PKA7", "url": "https://www.uniprot.org/uniprot/A0A1D5PKA7" } ], "pmid": "" }, { "name": "transcription regulator complex", "id": "GO:0005667", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005667", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PKA7", "url": "https://www.uniprot.org/uniprot/A0A1D5PKA7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PKA7", "url": "https://www.uniprot.org/uniprot/A0A1D5PKA7" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PKA7", "url": "https://www.uniprot.org/uniprot/A0A1D5PKA7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 235, "end_pos": 237, "annotation": "n_glycosylation_sequon" }, { "start_pos": 326, "end_pos": 328, "annotation": "n_glycosylation_sequon" }, { "start_pos": 625, "end_pos": 627, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A1D5PKA7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 660, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A1D5PKA7-F1.pdb" } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 129 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 235, "end_pos": 237 }, { "start_pos": 326, "end_pos": 328 }, { "start_pos": 625, "end_pos": 627 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "prediction_tool", "mining_tool", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "prediction_tool", "mining_tool", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }