{ "uniprot_canonical_ac": "A0A1D5PIQ4-1", "uniprot_ac": "A0A1D5PIQ4", "uniprot_id": "A0A1D5PIQ4_CHICK", "mass": { "chemical_mass": 34559.0, "monoisotopic_mass": 34559.0 }, "refseq": {}, "gene_names": [ { "name": "EN1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A1D5PIQ4", "id": "A0A1D5PIQ4" } ], "protein_names": [ { "name": "Homeobox protein engrailed-like", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PIQ4/entry#names_and_taxonomy", "id": "A0A1D5PIQ4" } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Gallus gallus", "taxid": 9031, "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PIQ4", "url": "https://www.uniprot.org/uniprot/A0A1D5PIQ4" } ], "common_name": "Chicken", "glygen_name": "Chicken", "reference_species": "Gallus gallus [9031]" } ], "gene": [ { "name": "EN1", "url": 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Classification" ] }, { "id": "IPR009057", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009057", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017970", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017970", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019549", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019549", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019737", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019737", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020479", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020479", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050720", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050720", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "gga:771008", "url": "https://www.genome.jp/dbget-bin/www_bget?gga:771008", 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"https://www.uniprot.org/uniprotkb/A0A1D5PIQ4/entry#A0A1D5PIQ4-1", "sequence": { "sequence": "MEEPPEGHGHHRDAAPPGPANGGGGGGGGSDGDSAPVSPSPAPASPAAPCPLPLPRRRPPPPPPPRTTNFFIDNILRPDFGCKKEPPAATGAATGAGGGGGGGGREQRDGAQSAGRENVNPLLARPPHAPSSALLCPDSNCAPDGSAPAGTAAKANPGTAAGAAGAAGAAKAQGDGGETPAAKYGEHGSPAILLMGSNNGGAVLKPDSQQPLVWPAWVYCTRYSDRPSSGPRTRKLKKKKTEKEDKRPRTAFTAEQLQRLKAEFQANRYITEQRRQSLAQELSLNESQIKIWFQNKRAKIKKATGIKNGLALHLMAQGLYNHSTTTVQDKEESE", "length": 334, "header": "tr|A0A1D5PIQ4-1|A0A1D5PIQ4_CHICK Isoform 1 of Homeobox protein engrailed-like OS=Gallus gallus OX=9031 GN=EN1 PE=3 SV=1 CANONICAL=A0A1D5PIQ4-1" }, "locus": { "chromosome": "7", "start_pos": 28138683, "end_pos": 28136628, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSGALT00010050542.1", "url": "https://www.ensembl.org/id/ENSGALT00010050542.1" }, { "database": "Ensembl Peptide", "id": "ENSGALP00010029834.1", "url": "https://www.ensembl.org/id/ENSGALP00010029834.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "gga:771008", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?gga:771008", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2JT82-1", "protein_name": "Homeobox protein engrailed-like", "gene_name": "En1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEEQQPEPKSQRDSGLGAVAAAAPGGLSLSLSPGASGSSGSDGDSVPVSPQPAPPSPPAAPCLPPLAHHPHLPPHPPPPPPPPPPPPPPQHLAAPAHQPQPAAQLHRTTNFFIDNILRPDFGCKKEQPLPQLLVASAAAGGGAAGGGSRVERDRSQTGAGRDPVHSLGTRASGAASLLCAPDANCGPPDGSQPATAVGAGASKAGNPAAAAAAAAAAAAAAVAAAAAAASKPSDSGGGSGGSAGSPGAQGAKFPEHNPAILLMGSANGGPVVKTDSQQPLVWPAWVYCTRYSDRPSSGPRTRKLKKKKNEKEDKRPRTAFTAEQLQRLKAEFQANRYITEQRRQTLAQELSLNESQIKIWFQNKRAKIKKATGIKNGLALHLMAQGLYNHSTTTVQDKDESE", "length": 402 }, "evidence": [ { "id": "A0A1D5PIQ4", "url": "https://omabrowser.org/oma/group/A0A1D5PIQ4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1N5R9-1", "protein_name": "Homeobox protein engrailed-like", "gene_name": "EN1", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MEEQQPEPKSQRDSGLGAAAAVAAAPGSLTLSLSPGASGSSGSDGDSVPVSPQPAPPSPPAAPCLPPLAHHPHLPPHPPPPPPPPPQQHLAAPAHQPQPAAQLHRTTNFFIDNILRPDFGCKKEQPPPQLLVAAAAAAGGGTGGGRVERDRGQTGSGRDPVHPLGTRAPGAASLLCTADGNCGPPDGSPPATAGGAGASKAGNPAAAAAAAAAAAVAAAAAAAAAAAKPSDSGGGSGGGVGSPGAQGAKYPEHSNPAILLMGSANGGPVVKTDSQQPLVWPAWVYCTRYSDRPSSGPRTRKLKKKKNEKEDKRPRTAFTAEQLQRLKAEFQANRYITEQRRQTLAQELSLNESQIKIWFQNKRAKIKKATGIKNGLALHLMAQGLYNHSTTTVQDKDESE", "length": 400 }, "evidence": [ { "id": "A0A1D5PIQ4", "url": "https://omabrowser.org/oma/group/A0A1D5PIQ4/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "P09065-1", "protein_name": "Homeobox protein engrailed-1", "gene_name": "En1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEEQQPEPKSQRDSGLGAVAAAAPSGLSLSLSPGASGSSGSDGDSVPVSPQPAPPSPPAAPCLPPLAHHPHLPPHPPPPPPPPPPPPQHLAAPAHQPQPAAQLHRTTNFFIDNILRPDFGCKKEQPLPQLLVASAAAGGGAAAGGGSRVERDRGQTGAGRDPVHSLGTRASGAASLLCAPDANCGPPDGSQPATAVSAGASKAGNPAAAAAAAAAAAAAAVAAAAAAASKPSDSGGGSGGNAGSPGAQGAKFPEHNPAILLMGSANGGPVVKTDSQQPLVWPAWVYCTRYSDRPSSGPRTRKLKKKKNEKEDKRPRTAFTAEQLQRLKAEFQANRYITEQRRQTLAQELSLNESQIKIWFQNKRAKIKKATGIKNGLALHLMAQGLYNHSTTTVQDKDESE", "length": 401 }, "evidence": [ { "id": "A0A1D5PIQ4", "url": "https://omabrowser.org/oma/group/A0A1D5PIQ4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q05925-1", "protein_name": "Homeobox protein engrailed-1", "gene_name": "EN1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEEQQPEPKSQRDSALGAAAAATPGGLSLSLSPGASGSSGSGSDGDSVPVSPQPAPPSPPAAPCLPPLAHHPHLPPHPPPPPPQHLAAPAHQPQPAAQLHRTTNFFIDNILRPDFGCKKEQPPPQLLVAAAARGGAGGGGRVERDRGQTAAGRDPVHPLGTRAPGAASLLCAPDANCGPPDGSQPAAAGAGASKAGNPAAAAAAAAAAVAAAAAAAAAKPSDTGGGGSGGGAGSPGAQGTKYPEHGNPAILLMGSANGGPVVKTDSQQPLVWPAWVYCTRYSDRPSSGPRTRKLKKKKNEKEDKRPRTAFTAEQLQRLKAEFQANRYITEQRRQTLAQELSLNESQIKIWFQNKRAKIKKATGIKNGLALHLMAQGLYNHSTTTVQDKDESE", "length": 392 }, "evidence": [ { "id": "A0A1D5PIQ4", "url": "https://omabrowser.org/oma/group/A0A1D5PIQ4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PIQ4", "url": "https://www.uniprot.org/uniprot/A0A1D5PIQ4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 19, "go_terms": [ { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PIQ4", "url": "https://www.uniprot.org/uniprot/A0A1D5PIQ4" } ], "pmid": "" }, { "name": "adult locomotory behavior", "id": "GO:0008344", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008344", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PIQ4", "url": "https://www.uniprot.org/uniprot/A0A1D5PIQ4" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PIQ4", "url": "https://www.uniprot.org/uniprot/A0A1D5PIQ4" } ], "pmid": "" }, { "name": "multicellular organism growth", "id": "GO:0035264", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035264", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PIQ4", "url": "https://www.uniprot.org/uniprot/A0A1D5PIQ4" } ], "pmid": "" }, { "name": "negative regulation of neuron apoptotic process", "id": "GO:0043524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043524", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PIQ4", "url": "https://www.uniprot.org/uniprot/A0A1D5PIQ4" } ], "pmid": "" }, { "name": "proximal/distal pattern formation", "id": "GO:0009954", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009954", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PIQ4", "url": "https://www.uniprot.org/uniprot/A0A1D5PIQ4" } ], "pmid": "" }, { "name": "neuron differentiation", "id": "GO:0030182", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030182", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PIQ4", "url": "https://www.uniprot.org/uniprot/A0A1D5PIQ4" } ], "pmid": "" }, { "name": "embryonic forelimb morphogenesis", "id": "GO:0035115", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035115", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PIQ4", "url": "https://www.uniprot.org/uniprot/A0A1D5PIQ4" } ], "pmid": "" }, { "name": "drinking behavior", "id": "GO:0042756", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042756", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PIQ4", "url": "https://www.uniprot.org/uniprot/A0A1D5PIQ4" } ], "pmid": "" }, { "name": "motor learning", "id": "GO:0061743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061743", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PIQ4", "url": "https://www.uniprot.org/uniprot/A0A1D5PIQ4" } ], "pmid": "" }, { "name": "social behavior", "id": "GO:0035176", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035176", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PIQ4", "url": "https://www.uniprot.org/uniprot/A0A1D5PIQ4" } ], "pmid": "" }, { "name": "dorsal/ventral pattern formation", "id": "GO:0009953", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009953", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PIQ4", "url": "https://www.uniprot.org/uniprot/A0A1D5PIQ4" } ], "pmid": "" }, { "name": "neuron development", "id": "GO:0048666", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048666", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PIQ4", "url": "https://www.uniprot.org/uniprot/A0A1D5PIQ4" } ], "pmid": "" }, { "name": "pigmentation", "id": "GO:0043473", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043473", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PIQ4", "url": "https://www.uniprot.org/uniprot/A0A1D5PIQ4" } ], "pmid": "" }, { "name": "cerebellum development", "id": "GO:0021549", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021549", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PIQ4", "url": "https://www.uniprot.org/uniprot/A0A1D5PIQ4" } ], "pmid": "" }, { "name": "embryonic brain development", "id": "GO:1990403", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990403", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PIQ4", "url": "https://www.uniprot.org/uniprot/A0A1D5PIQ4" } ], "pmid": "" }, { "name": "midbrain-hindbrain boundary development", "id": "GO:0030917", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030917", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PIQ4", "url": "https://www.uniprot.org/uniprot/A0A1D5PIQ4" } ], "pmid": "" }, { "name": "midbrain development", "id": "GO:0030901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030901", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PIQ4", "url": "https://www.uniprot.org/uniprot/A0A1D5PIQ4" } ], "pmid": "" }, { "name": "dopaminergic neuron differentiation", "id": "GO:0071542", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071542", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PIQ4", "url": "https://www.uniprot.org/uniprot/A0A1D5PIQ4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227", "url": 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