{ "uniprot_canonical_ac": "A0A1D5PCU3-1", "uniprot_ac": "A0A1D5PCU3", "uniprot_id": "A0A1D5PCU3_CHICK", "mass": { "chemical_mass": 57318.0, "monoisotopic_mass": 57318.0 }, "refseq": { "ac": "NP_001186150", "name": "E3 ubiquitin-protein ligase ARIH2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186150" }, "gene_names": [ { "name": "ARIH2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A1D5PCU3", "id": "A0A1D5PCU3" }, { "name": "ARIH2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186150", "id": "NP_001186150" } ], "protein_names": [ { "name": "RBR-type E3 ubiquitin transferase", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PCU3/entry#names_and_taxonomy", "id": "A0A1D5PCU3" }, { "name": "2.3.2.31", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PCU3/entry#names_and_taxonomy", "id": "A0A1D5PCU3" }, { "name": "E3 ubiquitin-protein ligase ARIH2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186150", "id": "NP_001186150" }, { "name": "protein ariadne-2 homolog; ariadne homolog 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186150", "id": "NP_001186150" } ], "function": [ { "annotation": "##Evidence-Data-START## Transcript exon combination :: HAEL01011517.1, SRR13267651.7224.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000252.1. On Nov 25, 2010 this sequence version replaced XP_414399.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments.", "evidence": [ { "database": "RefSeq", "id": "NP_001186150", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186150" } ] }, { "annotation": "Arih2 gene influences immune response and tissue development in chicken.", "evidence": [ { "database": "RefSeq", "id": "NP_001186150", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186150" }, { "database": "PubMed", "id": "31551339", "url": "https://glygen.org/publication/PubMed/31551339" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Gallus gallus", "taxid": 9031, "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PCU3", "url": "https://www.uniprot.org/uniprot/A0A1D5PCU3" } ], "common_name": "Chicken", "glygen_name": "Chicken", "reference_species": "Gallus gallus [9031]" } ], "gene": [ { "name": "ARIH2", "url": "https://www.uniprot.org/uniprot/A0A1D5PCU3", "locus": { "chromosome": "12", "start_pos": 11853173, "end_pos": 11884534, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSGALG00010020732", "url": "https://www.ensembl.org/id/ENSGALG00010020732" } ] } } ], "crossref": [ { "id": "ENSGALG00000006956", "url": "https://bgee.org/?page=gene&gene_id=ENSGALG00000006956", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd16773", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16773", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd20344", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20344", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd20360", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20360", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "416061", "url": "https://www.ncbi.nlm.nih.gov/gene/416061", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002867", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002867", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017907", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017907", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031127", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031127", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044066", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044066", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045840", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045840", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047555", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047555", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047556", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047556", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "gga:416061", "url": "https://www.genome.jp/dbget-bin/www_bget?gga:416061", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ICKVCHT", "url": "https://omabrowser.org/oma/group/ICKVCHT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A1D5PCU3", "url": "https://www.orthodb.org/?gene=A0A1D5PCU3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11685", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11685", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11685:SF210", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11685:SF210", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01485", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01485", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF19422", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19422", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "R-GGA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-983168", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001186150", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186150", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A1D5PCU3", "url": "https://www.uniprot.org/uniprot/A0A1D5PCU3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1D5PCU3-1", "url": "https://www.uniprot.org/uniprot/A0A1D5PCU3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V0ZEF5", "url": "https://www.uniprot.org/uniprot/A0A8V0ZEF5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V0ZEF5-1", "url": "https://www.uniprot.org/uniprot/A0A8V0ZEF5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V0ZFJ3", "url": "https://www.uniprot.org/uniprot/A0A8V0ZFJ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V0ZFJ3-1", "url": "https://www.uniprot.org/uniprot/A0A8V0ZFJ3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V0ZFS4", "url": "https://www.uniprot.org/uniprot/A0A8V0ZFS4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V0ZFS4-1", "url": "https://www.uniprot.org/uniprot/A0A8V0ZFS4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V0ZLV5", "url": "https://www.uniprot.org/uniprot/A0A8V0ZLV5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V0ZLV5-1", "url": "https://www.uniprot.org/uniprot/A0A8V0ZLV5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSVDMNSQGSDSNEEDYDPNCEEEEEDEDPGDIEDYYDGVANDVEQQGADAFDPEEYQFTCLTYKESESTLNEHMASLAATLKVSHAVAKLVLVSFHWQISEILERHKSNAAQLLVEARVQPTSSKHAMVHSSHHCAVCMQFVRKENLLSLACQHQFCRSCWEQHCTVLVKDGVGVGVSCMAQDCLLRTPEDFVFPLLPSEELKDKYRRYLFRDYVESHYQLQLCPGADCPMVIQVQEPKARRVQCNRCNEVFCFKCRQMYHAPTDCATIRKWLTKCADDSETANYISAHTKDCPKCNICIEKNGGCNHMQCSKCKHDFCWMCLGDWKTHGSEYYECSRYKENPDIVNQSQQAQAREALKKYLFYFERWENHNKSLQLEAQTYQRIQEKIQERVMNNLGTWIDWQYLQNAAKLLAKCRYTLQYTYPYAYYMESGPRKKLFEYQQAQLEAEIENLSWKVERADSYDRGDLENQMHIAEQRRRTLLKDFHDT", "length": 490, "header": "tr|A0A1D5PCU3-1|A0A1D5PCU3_CHICK Isoform 1 of RBR-type E3 ubiquitin transferase OS=Gallus gallus OX=9031 GN=ARIH2 PE=1 SV=2 CANONICAL=A0A1D5PCU3-1" }, "isoforms": [ { "isoform_ac": "A0A1D5PCU3-1", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PCU3/entry#A0A1D5PCU3-1", "sequence": { "sequence": "MSVDMNSQGSDSNEEDYDPNCEEEEEDEDPGDIEDYYDGVANDVEQQGADAFDPEEYQFTCLTYKESESTLNEHMASLAATLKVSHAVAKLVLVSFHWQISEILERHKSNAAQLLVEARVQPTSSKHAMVHSSHHCAVCMQFVRKENLLSLACQHQFCRSCWEQHCTVLVKDGVGVGVSCMAQDCLLRTPEDFVFPLLPSEELKDKYRRYLFRDYVESHYQLQLCPGADCPMVIQVQEPKARRVQCNRCNEVFCFKCRQMYHAPTDCATIRKWLTKCADDSETANYISAHTKDCPKCNICIEKNGGCNHMQCSKCKHDFCWMCLGDWKTHGSEYYECSRYKENPDIVNQSQQAQAREALKKYLFYFERWENHNKSLQLEAQTYQRIQEKIQERVMNNLGTWIDWQYLQNAAKLLAKCRYTLQYTYPYAYYMESGPRKKLFEYQQAQLEAEIENLSWKVERADSYDRGDLENQMHIAEQRRRTLLKDFHDT", "length": 490, "header": "tr|A0A1D5PCU3-1|A0A1D5PCU3_CHICK Isoform 1 of RBR-type E3 ubiquitin transferase OS=Gallus gallus OX=9031 GN=ARIH2 PE=1 SV=2 CANONICAL=A0A1D5PCU3-1" }, "locus": { "chromosome": "12", "start_pos": 11880984, "end_pos": 11856756, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSGALT00010050124.1", "url": "https://www.ensembl.org/id/ENSGALT00010050124.1" }, { "database": "Ensembl Peptide", "id": "ENSGALP00010029621.1", "url": "https://www.ensembl.org/id/ENSGALP00010029621.1" } ] } }, { "isoform_ac": "A0A8V0ZEF5-1", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PCU3/entry#A0A8V0ZEF5-1", "sequence": { "sequence": "MSVDMNSQGSDSNEEDYDPNCEEEEEDEDPGDIEDYYDGVANDVEQQGADAFDPEEYQFTCLTYKESESTLNEHMASLAATLKVSHAVAKLVLVSFHWQISEILERHKSNAAQLLVEARVQPTSSKHAMVHSSHHCAVCMQFVRKENLLSLACQHQFCRSCWEQHCTVLVKDGVGVGVSCMAQDCLLRTPEDFVFPLLPSEELKDKYRRYLFRDYVESHYQLQLCPGADCPMVIQVQEPKARRVQCNRCNEVFCFKCRQMYHAPTDCATIRKWLTKCADDSETANYISAHTKDCPKCNICIEKNGGCNHMVSNFCWMCLGDWKTHGSEYYECSRYKENPDIVNQSQQAQAREALKKYLFYFERWENHNKSLQLEAQTYQRIQEKIQERVMNNLGTWIDWQYLQNAAKLLAKCRYTLQYTYPYAYYMESGPRKKLFEYQQAQLEAEIENLSWKVERADSYDRGDLENQMHIAEQRRRTLLKDFHDT", "length": 485, "header": "tr|A0A8V0ZEF5-1|A0A8V0ZEF5_CHICK Computationally mapped isoform of RBR-type E3 ubiquitin transferase OS=Gallus gallus OX=9031 GN=ARIH2 PE=1 SV=1 CANONICAL=A0A1D5PCU3-1" }, "locus": { "chromosome": "12", "start_pos": 11880984, "end_pos": 11856756, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSGALT00010050108.1", "url": "https://www.ensembl.org/id/ENSGALT00010050108.1" }, { "database": "Ensembl Peptide", "id": "ENSGALP00010029608.1", "url": "https://www.ensembl.org/id/ENSGALP00010029608.1" } ] } }, { "isoform_ac": "A0A8V0ZFJ3-1", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PCU3/entry#A0A8V0ZFJ3-1", "sequence": { "sequence": "MSVDMNSQGSDSNEEDYDPNCEEEEEDEDPGDIEDYYDGVANDVEQQGADAFDPEEYQFTCLTYKESESTLNEHMASLAATLKVRKVDLIILLIVFFRHKSNAAQLLVEARVQPTSSKHAMVHSSHHCAVCMQFVRKENLLSLACQHQFCRSCWEQHCTVLVKDGVGVGVSCMAQDCLLRTPEDFVFPLLPSEELKDKYRRYLFRDYVESHYQLQLCPGADCPMVIQVQEPKARRVQCNRCNEVFCFKCRQMYHAPTDCATIRKWLTKCADDSETANYISAHTKDCPKCNICIEKNGGCNHMQCSKCKHDFCWMCLGDWKTHGSEYYECSRYKENPDIVNQSQQAQAREALKKYLFYFERWENHNKSLQLEAQTYQRIQEKIQERVMNNLGTWIDWQYLQNAAKLLAKCRYTLQYTYPYAYYMESGPRKKLFEYQQAQLEAEIENLSWKVERADSYDRGDLENQMHIAEQRRRTLLKDFHDT", "length": 482, "header": "tr|A0A8V0ZFJ3-1|A0A8V0ZFJ3_CHICK Computationally mapped isoform of RBR-type E3 ubiquitin transferase OS=Gallus gallus OX=9031 GN=ARIH2 PE=1 SV=1 CANONICAL=A0A1D5PCU3-1" }, "locus": { "chromosome": "12", "start_pos": 11880984, "end_pos": 11856756, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSGALT00010050117.1", "url": "https://www.ensembl.org/id/ENSGALT00010050117.1" }, { "database": "Ensembl Peptide", "id": "ENSGALP00010029614.1", "url": "https://www.ensembl.org/id/ENSGALP00010029614.1" } ] } }, { "isoform_ac": "A0A8V0ZFS4-1", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PCU3/entry#A0A8V0ZFS4-1", "sequence": { "sequence": "MSVDMNSQGSDSNEEDYDPNCEEEEEDEDPGDIEDYYDGVANDVEQQGADAFDPEEYQFTCLTYKESESTLNEHMASLAATLKNLISSSTIFLTSFITLEDFPLRQSSFLLALFLSLLTRRCFSSAALDMSIGHV", "length": 135, "header": "tr|A0A8V0ZFS4-1|A0A8V0ZFS4_CHICK Computationally mapped isoform of Ariadne RBR E3 ubiquitin protein ligase 2 OS=Gallus gallus OX=9031 GN=ARIH2 PE=4 SV=1 CANONICAL=A0A1D5PCU3-1" }, "locus": { "chromosome": "12", "start_pos": 11880984, "end_pos": 11872386, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSGALT00010050101.1", "url": "https://www.ensembl.org/id/ENSGALT00010050101.1" }, { "database": "Ensembl Peptide", "id": "ENSGALP00010029603.1", "url": "https://www.ensembl.org/id/ENSGALP00010029603.1" } ] } }, { "isoform_ac": "A0A8V0ZLV5-1", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PCU3/entry#A0A8V0ZLV5-1", "sequence": { "sequence": "MSVDMNSQGSDSNEEDYDPNCEEEEEDEDPGDIEDYYDGVANDVEQQGADAFDPEEYQFTCLTYKESESTLNEHMASLAATLKVSHAVAKLVLVSFHWQISEILERHKSNAAQLLVEARVQPTSSKHAMVHSSHHCAVCMQFVRKENLLSLACQHQFCRSCWEQHCTVLVKDGVSCMAQDCLLRTPEDFVFPLLPSEELKDKYRRYLFRDYVESHYQLQLCPGADCPMVIQVQEPKARRVQCNRCNEVFCFKCRQMYHAPTDCATIRKWLTKCADDSETANYISAHTKDCPKCNICIEKNGGCNHMQCSKCKHDFCWMCLGDWKTHGSEYYECSRYKENPDIVNQSQQAQAREALKKYLFYFERWENHNKSLQLEAQTYQRIQEKIQERVMNNLGTWIDWQYLQNAAKLLAKCRYTLQYTYPYAYYMESGPRKKLFEYQQAQLEAEIENLSWKVERADSYDRGDLENQMHIAEQRRRTLLKDFHDT", "length": 486, "header": "tr|A0A8V0ZLV5-1|A0A8V0ZLV5_CHICK Computationally mapped isoform of RBR-type E3 ubiquitin transferase OS=Gallus gallus OX=9031 GN=ARIH2 PE=1 SV=1 CANONICAL=A0A1D5PCU3-1" }, "locus": { "chromosome": "12", "start_pos": 11880984, "end_pos": 11856756, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSGALT00010050121.1", "url": "https://www.ensembl.org/id/ENSGALT00010050121.1" }, { "database": "Ensembl Peptide", "id": "ENSGALP00010029618.1", "url": "https://www.ensembl.org/id/ENSGALP00010029618.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Arih2 gene influences immune response and tissue development in chicken.", "journal": "Bioscience reports", "date": "2019-10-30", "authors": "Wu Guanxian, Xu Sifan, Zhang Wanting, Liu Yang, Wang Qiuyuan, Man Chaolai", "evidence": [ { "database": "RefSeq", "id": "NP_001186150", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186150" } ], "reference": [ { "type": "PubMed", "id": "31551339", "url": "https://glygen.org/publication/PubMed/31551339" } ] } ], "pathway": [ { "id": "gga:416061", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?gga:416061", "resource": "KEGG Pathway" }, { "id": "R-GGA-983168", "name": "Antigen processing: Ubiquitination & Proteasome degradation", "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-983168", "resource": "Reactome", "description": "Antigen processing: Ubiquitination & Proteasome degradation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1SZT7-1", "protein_name": "RBR-type E3 ubiquitin transferase", "gene_name": "ARIH2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSVDMNSQGSDSNEEDYDPNCEEEEEDEDPGDIEDYYVGVASDVEQQGADAFDPEEYQFTCLTYKESEGALNEHMTSLASVLKVSHSVAKLILVNFHWQVAEILDRYKSNSAQLLVEARVQPNPLKHVPTSHPPHHCAVCMQFVRKENLLSLACQHQFCRSCWEQHCSVLVKDGVGVGVSCMAQDCPLRTPEDFVFPLLPNEELRDKYRRYLFRDYVESHYQLQLCPGADCPMVIRVQEPRARRVQCNRCNEVFCFKCRQMYHAPTDCATIRKWLTKCADDSETANYISAHTKDCPKCNICIEKNGGCNHMQCSKCKHDFCWMCLGDWKTHGSEYYECSRYKENPDIVNQSQQAQAREALKKYLFYFERWENHNKSLQLEAQTYQRIHEKIQERVMNNLGTWIDWQYLQNAAKLLAKCRYTLQYTYPYAYYMESGPRKKLFEYQQAQLEAEIENLSWKVERADSYDRGDLENQMHIAEQRRRTLLKDFHDT", "length": 491 }, "evidence": [ { "id": "A0A1D5PCU3", "url": "https://omabrowser.org/oma/group/A0A1D5PCU3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "D3ZJB8-1", "protein_name": "RBR-type E3 ubiquitin transferase", "gene_name": "Arih2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSVDMNSQGSDSNEEDYDPNCEEEEEEEEDPGDIEDYYVGVASDVEQQGADAFDPEEYQFTCLTYKESEGALHEHMTSLASALKVSHSVAKLILVNFHWQVSEILDRYRSNSAQLLVEARVQPNPSKHVPTAHPPHHCAVCMQFVRKENLLSLTCQHQFCRSCWEQHCSVLVKDGVGVGISCMAQDCPLRTPEDFVFPLLPNEELRDKYRRYLFRDYVESHYQLQLCPGADCPMVIRVQEPRARRVQCNRCNEVFCFKCRQMYHAPTDCATIRKWLTKCADDSETANYISAHTKDCPKCNICIEKNGGCNHMQCSKCKHDFCWMCLGDWKTHGSEYYECSRYKENPDIVNQSQQAQAREALKKYLFYFERWENHNKSLQLEAQTYQRIHEKIQERVMNNLGTWIDWQYLQNAAKLLAKCRYTLQYTYPYAYYMESGPRKKLFEYQQAQLEAEIENLSWKVERADSYDRGDLENQMHIAEQRRRTLLKDFHDT", "length": 492 }, "evidence": [ { "id": "A0A1D5PCU3", "url": "https://omabrowser.org/oma/group/A0A1D5PCU3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "E1B8R6-1", "protein_name": "RBR-type E3 ubiquitin transferase", "gene_name": "ARIH2", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MSVDMNSQGSDSNEEDYDPNCEEEEEDEDPGDIEDYYVGVASDVEQQGADSFDPEEYQFTCLTYKESEGALNEHMTSLASVLKVSHSVAKLILVNFHWQVAEILDRYKSNSAQLLVEARVQPNPSKHVPPAHSPHHCAVCMQFVRKENLLSLACQHQFCRSCWEQHCSVLVKDGVGVGVSCMAQDCPLRTPEDFVFPLLPNEELRDKYRRYLFRDYVESHYQLQLCPGADCPMVIRVQEPRARRVQCNRCNEVFCFKCRQMYHAPTDCATIRKWLTKCADDSETANYISAHTKDCPKCNICIEKNGGCNHMQCSKCKHDFCWMCLGDWKTHGSEYYECSRYKENPDIVNQSQQAQAREALKKYLFYFERWENHNKSLQLEAQTYQRIHEKIQERVMNNLGTWIDWQYLQNAAKLLAKCRYTLQYTYPYAYYMESGPRKKLALPWLPSPLLLTLLLYPYSLNTSRLSWRLRSKTCRGKWSGRTAMTEGT", "length": 488 }, "evidence": [ { "id": "A0A1D5PCU3", "url": "https://omabrowser.org/oma/group/A0A1D5PCU3/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "O76924-1", "protein_name": "Potential E3 ubiquitin-protein ligase ariadne-2", "gene_name": "ari-2", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MDSDIEMDMESDNDGEYDDDYDYYNTGEDCDVERLDPKRADPEYFEYECLTVEDIEKLLNERVEKLNTILQITPSLAKVLLLEHQWNNVAVVEKYRQDANALLVTARIKPPSVAVTDTASTSAAAASAQLLRLGSSGYKTTASATPQYRSQMCPVCASSQLGDKFYSLACGHSFCKDCWTIYFETQIFQGISTQIGCMAQMCNVRVPEDLVLTLVTRPVMRDKYQQFAFKDYVKSHPELRFCPGPNCQIIVQSSEISAKRAICKACHTGFCFRCGMDYHAPTDCQVIKKWLTKCADDSETANYISAHTKDCPKCHICIEKNGGCNHMQCFNCKHDFCWMCLGDWKTHGSEYYECSRYKDNPNIANESVHVQAREALKKYLHYYERWENHSKSLKLEQQTIDRLRQRINSKVMNGSGTWIDWQYLFNAAALLAKCRYTLQYTYPYAYYMEAGSRKNLFEYQQAQLEAEIENLSWKIERAETTDLGDLENQMDIAEKRRTTLLKDFFPVDA", "length": 509 }, "evidence": [ { "id": "A0A1D5PCU3", "url": "https://omabrowser.org/oma/group/A0A1D5PCU3/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "O95376-1", "protein_name": "E3 ubiquitin-protein ligase ARIH2", "gene_name": "ARIH2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSVDMNSQGSDSNEEDYDPNCEEEEEEEEDDPGDIEDYYVGVASDVEQQGADAFDPEEYQFTCLTYKESEGALNEHMTSLASVLKVSHSVAKLILVNFHWQVSEILDRYKSNSAQLLVEARVQPNPSKHVPTSHPPHHCAVCMQFVRKENLLSLACQHQFCRSCWEQHCSVLVKDGVGVGVSCMAQDCPLRTPEDFVFPLLPNEELREKYRRYLFRDYVESHYQLQLCPGADCPMVIRVQEPRARRVQCNRCNEVFCFKCRQMYHAPTDCATIRKWLTKCADDSETANYISAHTKDCPKCNICIEKNGGCNHMQCSKCKHDFCWMCLGDWKTHGSEYYECSRYKENPDIVNQSQQAQAREALKKYLFYFERWENHNKSLQLEAQTYQRIHEKIQERVMNNLGTWIDWQYLQNAAKLLAKCRYTLQYTYPYAYYMESGPRKKLFEYQQAQLEAEIENLSWKVERADSYDRGDLENQMHIAEQRRRTLLKDFHDT", "length": 493 }, "evidence": [ { "id": "A0A1D5PCU3", "url": "https://omabrowser.org/oma/group/A0A1D5PCU3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q54XG4-1", "protein_name": "RBR-type E3 ubiquitin transferase", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MDKDLILAQLLEFGYDPVVAQTALEQTNWKDIDKAIDYIYTHFGEGMNKAATAMEYTQNKNNSTTKPTSTQAPISRSNSKLKTSGKRIKSSITISTGSEEYNSDNEYEDYDEENEYYQDVDDYEFDIAVVDAFPKTNTVIQAVDIVKTALSEIDKIASITETSPSAATLLLCHFQWNGNKLLERYYEDPEKVIAQAGIKKIDQFFTHQNVKGESCSVCADDLDSLNGSYLPCKHYSCNDCWNQYLSLKVLEGGATSITCMGLKCPSVIPDEFINLVAPTVYPKYLERLAQTYVDQNPNMRWCPAPKCGNALKADSQTEATALCSCGFKICFKCKQESHFPADCEKMKHWKKKCEDDSETANWISTNTQDCPKCHSAIEKNGGCMHMTCKKCKHEFCWICLGNWIGHSNCNSYKKEENSNKSESKKQLERYLFYFHRFNTHEQAKKFETKLRTAALETIISFQNKTDKRWIDIKFVETSTEILIQCRRTLKYTYVYGYFMEDGPEKNLFEYIQSDLEKTTEQLSFLLSQAHQDLKIFDLKEMTNLASTKLKHLLEGVEDGFINQ", "length": 563 }, "evidence": [ { "id": "A0A1D5PCU3", "url": "https://omabrowser.org/oma/group/A0A1D5PCU3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q8W468-1", "protein_name": "Probable E3 ubiquitin-protein ligase ARI8", "gene_name": "ARI8", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MEADDDFYSGTENYSDYADSDEDDADGEYEFVDDAADDSDDLIFRRRQQNYSVLSEADICKLQEDDISRISTVLSISRNSSAILLRHYNWCVSRVHDEWFADEEKVRDAVGLLEKPVVDFPTDGELDCGICFETFLSDKLHAAACGHPFCDSCWEGYITTAINDGPGCLTLRCPDPSCRAAVGQDMINLLAPDKDKQKYTSYFVRSYVEDNRKTKWCPAPGCDYAVNFVVGSGNYDVNCRCCYSFCWNCAEEAHRPVDCDTVSKWVLKNSAESENMNWILANSKPCPKCKRPIEKNQGCMHITCTPPCKFEFCWLCLGAWTEHGEKTGGFYACNRYEAAKQDGIYDETEKRREMAKNSLERYTHYYERWATNQSSRQKALLDLKKMQTDDIEKLSDIQCQPESQLKFIIEAWLQIVECRRVLKWTYAYGFYIPDQEHGKRVFFEYLQGEAESGLERLHQCAEKELLPYLDAKGPSEDFNEFRTKLAGLTSVTKNYFENLVRALENGLSDVNSHDAYDRTSSSKSLGGKTKGSSSKASSSDSSHWPCEYCTYVNPRSTTICQMCEHGR", "length": 567 }, "evidence": [ { "id": "A0A1D5PCU3", "url": "https://omabrowser.org/oma/group/A0A1D5PCU3/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9Z1K6-1", "protein_name": "E3 ubiquitin-protein ligase ARIH2", "gene_name": "Arih2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSVDMNSQGSDSNEEDYDPNCEEEEEEEEDPGDIEDYYVGVASDVEQQGADAFDPEEYQFTCLTYKESEGALHEHMTSLASVLKVSHSVAKLILVNFHWQVSEILDRYRSNSAQLLVEARVQPNPSKHVPTAHPPHHCAVCMQFVRKENLLSLACQHQFCRSCWEQHCSVLVKDGVGVGISCMAQDCPLRTPEDFVFPLLPNEELRDKYRRYLFRDYVESHFQLQLCPGADCPMVIRVQEPRARRVQCNRCSEVFCFKCRQMYHAPTDCATIRKWLTKCADDSETANYISAHTKDCPKCNICIEKNGGCNHMQCSKCKHDFCWMCLGDWKTHGSEYYECSRYKENPDIVNQSQQAQAREALKKYLFYFERWENHNKSLQLEAQTYERIHEKIQERVMNNLGTWIDWQYLQNAAKLLAKCRYTLQYTYPYAYYMESGPRKKLFEYQQAQLEAEIENLSWKVERADSYDRGDLENQMHIAEQRRRTLLKDFHDT", "length": 492 }, "evidence": [ { "id": "A0A1D5PCU3", "url": "https://omabrowser.org/oma/group/A0A1D5PCU3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PCU3", "url": "https://www.uniprot.org/uniprot/A0A1D5PCU3" } ], "pmid": "" }, { "name": "ubiquitin-protein transferase activity", "id": "GO:0004842", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004842", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PCU3", "url": "https://www.uniprot.org/uniprot/A0A1D5PCU3" } ], "pmid": "" }, { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PCU3", "url": "https://www.uniprot.org/uniprot/A0A1D5PCU3" } ], "pmid": "" }, { "name": "ubiquitin conjugating enzyme binding", "id": "GO:0031624", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031624", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PCU3", "url": "https://www.uniprot.org/uniprot/A0A1D5PCU3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PCU3", "url": "https://www.uniprot.org/uniprot/A0A1D5PCU3" } ], "pmid": "" }, { "name": "protein polyubiquitination", "id": "GO:0000209", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000209", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PCU3", "url": "https://www.uniprot.org/uniprot/A0A1D5PCU3" } ], "pmid": "" }, { "name": "ubiquitin-dependent protein catabolic process", "id": "GO:0006511", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006511", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PCU3", "url": "https://www.uniprot.org/uniprot/A0A1D5PCU3" } ], "pmid": "" }, { "name": "protein K48-linked ubiquitination", "id": "GO:0070936", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070936", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PCU3", "url": "https://www.uniprot.org/uniprot/A0A1D5PCU3" } ], "pmid": "" }, { "name": "protein K63-linked ubiquitination", "id": "GO:0070534", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070534", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PCU3", "url": "https://www.uniprot.org/uniprot/A0A1D5PCU3" } ], "pmid": "" }, { "name": "hematopoietic stem cell proliferation", "id": "GO:0071425", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071425", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PCU3", "url": "https://www.uniprot.org/uniprot/A0A1D5PCU3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PCU3", "url": "https://www.uniprot.org/uniprot/A0A1D5PCU3" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PCU3", "url": "https://www.uniprot.org/uniprot/A0A1D5PCU3" } ], "pmid": "" }, { "name": "ubiquitin ligase complex", "id": "GO:0000151", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000151", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PCU3", "url": "https://www.uniprot.org/uniprot/A0A1D5PCU3" } ], "pmid": "" }, { "name": "Cul5-RING ubiquitin ligase complex", "id": "GO:0031466", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031466", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PCU3", "url": "https://www.uniprot.org/uniprot/A0A1D5PCU3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 348, "end_pos": 350, "annotation": "n_glycosylation_sequon" }, { "start_pos": 373, "end_pos": 375, "annotation": "n_glycosylation_sequon" }, { "start_pos": 453, "end_pos": 455, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-GGA-983140", "name": "Transfer of Ub from E2 to substrate and release of E2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A8V0Y0Q2-1", "F1NRC6-1", "F1NTZ8-1", "A0A1D5PCU3-1", "F1NL77-1", "Q5ZHY5-1", "A0A1D5NXC7-1", "A0A8V0YL05-1", "A0A8V0Z1W7-1", "A0A8V0XGC1-1", "Q5ZKX6-1", "A0A8V0Z0F1-1", "Z4YJC3-1", "E1BZ35-1", "E1C3Q9-1", "F1NC08-1", "A0A8V0XTY5-1", "F1P2G0-1", "E1C656-1", "A0A8V0YDQ1-1", "A0A8V1ANR3-1" ], "evidence": [ { "id": "R-GGA-983140", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-983140" } ] }, { "id": "R-GGA-983147", "name": "Release of E3 from polyubiquitinated substrate", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A8V0Y0Q2-1", "F1NRC6-1", "F1NTZ8-1", "A0A1D5PCU3-1", "F1NL77-1", "Q5ZHY5-1", "A0A1D5NXC7-1", "A0A8V0YL05-1", "Z4YJC3-1", "E1BZ35-1", "E1C3Q9-1", "F1NC08-1", "A0A8V0XTY5-1", "F1P2G0-1", "E1C656-1", "A0A8V0YDQ1-1" ], "evidence": [ { "id": "R-GGA-983147", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-983147" } ] }, { "id": "R-GGA-983156", "name": "Polyubiquitination of substrate", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A8V0Y0Q2-1", "F1NRC6-1", "F1NTZ8-1", "A0A1D5PCU3-1", "F1NL77-1", "Q5ZHY5-1", "A0A1D5NXC7-1", "A0A8V0YL05-1", "A0A8V0Z1W7-1", "A0A8V0XGC1-1", "Q5ZKX6-1", "A0A8V0Z0F1-1", "Z4YJC3-1", "E1BZ35-1", "E1C3Q9-1", "F1NC08-1", "A0A8V0XTY5-1", "F1P2G0-1", "E1C656-1", "A0A8V0YDQ1-1", "A0A8V1ANR3-1" ], "evidence": [ { "id": "R-GGA-983156", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-983156" } ] }, { "id": "R-GGA-983157", "name": "Interaction of E3 with substrate and E2-Ub complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A8V0Y0Q2-1", "F1NRC6-1", "F1NTZ8-1", "A0A1D5PCU3-1", "F1NL77-1", "Q5ZHY5-1", "A0A1D5NXC7-1", "A0A8V0YL05-1", "A0A8V0Z1W7-1", "A0A8V0XGC1-1", "Q5ZKX6-1", "A0A8V0Z0F1-1", "Z4YJC3-1", "E1BZ35-1", "E1C3Q9-1", "F1NC08-1", "A0A8V0XTY5-1", "F1P2G0-1", "E1C656-1", "A0A8V0YDQ1-1", "A0A8V1ANR3-1" ], "evidence": [ { "id": "R-GGA-983157", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-983157" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A1D5NXC7", "gene_name": "AREL1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A1D5NXC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A1D5NXC7" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "A0A1D5NXC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A1D5NXC7" } ] } ] }, { "uniprot_ac": "A0A1D5PCU3", "gene_name": "ARIH2", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "A0A1D5PCU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A1D5PCU3" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "A0A1D5PCU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A1D5PCU3" } ] } ] }, { "uniprot_ac": "A0A8V0XGC1", "gene_name": "UBE2J1", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "A0A8V0XGC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V0XGC1" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "A0A8V0XGC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V0XGC1" } ] } ] }, { "uniprot_ac": "A0A8V0XTY5", "gene_name": "SH3RF1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A8V0XTY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V0XTY5" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0A8V0XTY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V0XTY5" } ] } ] }, { "uniprot_ac": "A0A8V0Y0Q2", "gene_name": "RNF144B", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "A0A8V0Y0Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V0Y0Q2" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "A0A8V0Y0Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V0Y0Q2" } ] } ] }, { "uniprot_ac": "A0A8V0YDQ1", "gene_name": "WWP1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A8V0YDQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V0YDQ1" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "A0A8V0YDQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V0YDQ1" } ] } ] }, { "uniprot_ac": "A0A8V0YL05", "gene_name": "UBE3A", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A8V0YL05", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V0YL05" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "A0A8V0YL05", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V0YL05" } ] } ] }, { "uniprot_ac": "A0A8V0Z0F1", "gene_name": "UBE2U", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A8V0Z0F1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V0Z0F1" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "A0A8V0Z0F1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V0Z0F1" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "A0A8V0Z0F1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V0Z0F1" } ] }, { "ec_number": "2.3.2.24", "activity": "", "evidence": [ { "id": "A0A8V0Z0F1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V0Z0F1" } ] } ] }, { "uniprot_ac": "A0A8V0Z1W7", "gene_name": "UBE2K", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "A0A8V0Z1W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V0Z1W7" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "A0A8V0Z1W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V0Z1W7" } ] } ] }, { "uniprot_ac": "A0A8V1ANR3", "gene_name": "UBE2G1", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "A0A8V1ANR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V1ANR3" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "A0A8V1ANR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V1ANR3" } ] } ] }, { "uniprot_ac": "E1BZ35", "gene_name": "RNF182", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BZ35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E1BZ35" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BZ35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E1BZ35" } ] } ] }, { "uniprot_ac": "E1C3Q9", "gene_name": "SIAH2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1C3Q9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E1C3Q9" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1C3Q9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E1C3Q9" } ] } ] }, { "uniprot_ac": "E1C656", "gene_name": "HACE1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1C656", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E1C656" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "E1C656", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E1C656" } ] } ] }, { "uniprot_ac": "F1NC08", "gene_name": "RNF138", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1NC08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1NC08" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1NC08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1NC08" } ] } ] }, { "uniprot_ac": "F1NL77", "gene_name": "CBLB", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1NL77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1NL77" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1NL77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1NL77" } ] } ] }, { "uniprot_ac": "F1NRC6", "gene_name": "RLIM", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1NRC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1NRC6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1NRC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1NRC6" } ] } ] }, { "uniprot_ac": "F1NTZ8", "gene_name": "HECW2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1NTZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1NTZ8" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1NTZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1NTZ8" } ] } ] }, { "uniprot_ac": "F1P2G0", "gene_name": "SIAH1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1P2G0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1P2G0" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1P2G0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1P2G0" } ] } ] }, { "uniprot_ac": "Q5ZHY5", "gene_name": "STUB1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q5ZHY5", "database": "UniProtKB", "url": 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"sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }