{ "uniprot_canonical_ac": "A0A1D5PB24-1", "uniprot_ac": "A0A1D5PB24", "uniprot_id": "A0A1D5PB24_CHICK", "mass": { "chemical_mass": 104798.0, "monoisotopic_mass": 104798.0 }, "refseq": { "ac": "XP_426162", "name": "leucine-rich repeat-containing G-protein coupled receptor 4 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_426162" }, "gene_names": [ { "name": "LGR4", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A1D5PB24", "id": "A0A1D5PB24" }, { "name": "LGR4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_426162", "id": "XP_426162" } ], "protein_names": [ { "name": "Leucine rich repeat containing G protein-coupled receptor 4", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PB24/entry#names_and_taxonomy", "id": "A0A1D5PB24" }, { "name": "leucine-rich repeat-containing G-protein coupled receptor 4 isoform X1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_426162", "id": "XP_426162" } ], "function": [ { "annotation": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052536.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Dec 16, 2011 this sequence version replaced XP_426162.2. COMPLETENESS: full length.", "evidence": [ { "database": "RefSeq", "id": "XP_426162", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_426162" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Gallus gallus", "taxid": 9031, "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PB24", "url": "https://www.uniprot.org/uniprot/A0A1D5PB24" } ], "common_name": "Chicken", "glygen_name": "Chicken", "reference_species": "Gallus gallus [9031]" } ], "gene": [ { "name": "LGR4", "url": "https://www.uniprot.org/uniprot/A0A1D5PB24", "locus": { "chromosome": "5", "start_pos": 3835419, "end_pos": 3895806, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSGALG00010019873", "url": "https://www.ensembl.org/id/ENSGALG00010019873" } ] } } ], "crossref": [ { "id": "A0A1D5PB24", "url": "https://alphafold.ebi.ac.uk/entry/A0A1D5PB24", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSGALG00000040834", "url": "https://bgee.org/?page=gene&gene_id=ENSGALG00000040834", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15361", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15361", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "428605", "url": "https://www.ncbi.nlm.nih.gov/gene/428605", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000372", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000372", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002131", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002131", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "gga:428605", "url": "https://www.genome.jp/dbget-bin/www_bget?gga:428605", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PPGNCSM", "url": "https://omabrowser.org/oma/group/PPGNCSM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A1D5PB24", "url": "https://www.orthodb.org/?gene=A0A1D5PB24", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24372", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24372", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24372:SF77", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24372:SF77", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00001", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00001", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00560", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00560", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF01462", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01462", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF13516", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13516", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF13855", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13855", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "R-GGA-4641263", "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-4641263", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "XP_426162", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_426162", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A1D5PB24", "url": "https://www.uniprot.org/uniprot/A0A1D5PB24", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1D5PB24-1", "url": "https://www.uniprot.org/uniprot/A0A1D5PB24-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V0Z544", "url": "https://www.uniprot.org/uniprot/A0A8V0Z544", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V0Z544-1", "url": "https://www.uniprot.org/uniprot/A0A8V0Z544-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V0ZBS3", "url": "https://www.uniprot.org/uniprot/A0A8V0ZBS3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V0ZBS3-1", "url": "https://www.uniprot.org/uniprot/A0A8V0ZBS3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V0ZCD2", "url": "https://www.uniprot.org/uniprot/A0A8V0ZCD2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V0ZCD2-1", "url": "https://www.uniprot.org/uniprot/A0A8V0ZCD2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V0ZID2", "url": "https://www.uniprot.org/uniprot/A0A8V0ZID2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V0ZID2-1", "url": "https://www.uniprot.org/uniprot/A0A8V0ZID2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRCLALLGLVAWGLGSSAGPSGGASPPPCPASCSCDGDRGVDCSGRGLAAVPPGLSAFTQALDVSMNNITRLPEDAFKNFPYLEELRLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPNEAIRGLSGLQSLRLDANHITAVPKDSFEGLVQLRHLWLDDNSLTEVPIHPLSNLPSLQALTLALNKITHIPDYAFTNLSSLVVLHLHNNKIKTIGKHCFDGLDNLETLDLNYNNMVEFPEAIKALPNLKELAFHSNYISIIPDGAFAGNPLLRMIHLYDNPLSFVGNSAFQNLSDLHSLVIRGASMVQWFPNLTGTVNLESLTLTGTKINSIPVNLCQEQKMLRTLDLSYNNIKDLPSFTGCRSLEEISLQHNQIHEITDDTFQGLSSLRILDLSRNRICKIHKEAFTTIGAIVNLDLSFNELTSVPTEGLSGLNQLKLAGNSELKEALAAQNFAKLRSLSVPYAYQCCAFWGCDSYLNSNAEDSSHQDQDAMGDREKTDADGLRNEENAELGQTIIHCTPAIGAFKPCEYLLGSWMIRLTVWFIFLVALFFNLLVMLTVFASCAPLPSSKLFIGLISVSNLFMGVYTGILTFLDAISWGRFAEFGIWWETGSGCRVAGFLAVFSSESAIFFLMLAAVERSFSAKEIIKKGKSNHQKQFQIAAVLAFLCAVVAGCLPLFHKAEYSASPLCLPFPTGETPSLGFTVTLVLLNSLAFLLMAIIYTKLYCNLEKEDLSENSQSCMIKHVAWLIFTNCIFFCPVAFFSFAPLITAISISPEIMKSVTLIFFPLPACLNPVLYVFFNPKFKEDWKLLRRQVTRKNGVVAISISAQGGCATQDFYYDCGMYTHLQGNVAMCECCESLLLSKPVPCKHLIKSHSCPTLAVVPCQRPDGYWSDCGTQSAHSDYADEDDSFVSDSSDQVQACGRACFYQSRGFPLVRYAYNINIPRIKD", "length": 952, "header": "tr|A0A1D5PB24-1|A0A1D5PB24_CHICK Isoform 1 of Leucine rich repeat containing G protein-coupled receptor 4 OS=Gallus gallus OX=9031 GN=LGR4 PE=4 SV=1 CANONICAL=A0A1D5PB24-1" }, "isoforms": [ { "isoform_ac": "A0A1D5PB24-1", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PB24/entry#A0A1D5PB24-1", "sequence": { "sequence": "MRCLALLGLVAWGLGSSAGPSGGASPPPCPASCSCDGDRGVDCSGRGLAAVPPGLSAFTQALDVSMNNITRLPEDAFKNFPYLEELRLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPNEAIRGLSGLQSLRLDANHITAVPKDSFEGLVQLRHLWLDDNSLTEVPIHPLSNLPSLQALTLALNKITHIPDYAFTNLSSLVVLHLHNNKIKTIGKHCFDGLDNLETLDLNYNNMVEFPEAIKALPNLKELAFHSNYISIIPDGAFAGNPLLRMIHLYDNPLSFVGNSAFQNLSDLHSLVIRGASMVQWFPNLTGTVNLESLTLTGTKINSIPVNLCQEQKMLRTLDLSYNNIKDLPSFTGCRSLEEISLQHNQIHEITDDTFQGLSSLRILDLSRNRICKIHKEAFTTIGAIVNLDLSFNELTSVPTEGLSGLNQLKLAGNSELKEALAAQNFAKLRSLSVPYAYQCCAFWGCDSYLNSNAEDSSHQDQDAMGDREKTDADGLRNEENAELGQTIIHCTPAIGAFKPCEYLLGSWMIRLTVWFIFLVALFFNLLVMLTVFASCAPLPSSKLFIGLISVSNLFMGVYTGILTFLDAISWGRFAEFGIWWETGSGCRVAGFLAVFSSESAIFFLMLAAVERSFSAKEIIKKGKSNHQKQFQIAAVLAFLCAVVAGCLPLFHKAEYSASPLCLPFPTGETPSLGFTVTLVLLNSLAFLLMAIIYTKLYCNLEKEDLSENSQSCMIKHVAWLIFTNCIFFCPVAFFSFAPLITAISISPEIMKSVTLIFFPLPACLNPVLYVFFNPKFKEDWKLLRRQVTRKNGVVAISISAQGGCATQDFYYDCGMYTHLQGNVAMCECCESLLLSKPVPCKHLIKSHSCPTLAVVPCQRPDGYWSDCGTQSAHSDYADEDDSFVSDSSDQVQACGRACFYQSRGFPLVRYAYNINIPRIKD", "length": 952, "header": "tr|A0A1D5PB24-1|A0A1D5PB24_CHICK Isoform 1 of Leucine rich repeat containing G protein-coupled receptor 4 OS=Gallus gallus OX=9031 GN=LGR4 PE=4 SV=1 CANONICAL=A0A1D5PB24-1" }, "locus": { "chromosome": "5", "start_pos": 3895607, "end_pos": 3837132, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSGALT00010048052.1", "url": "https://www.ensembl.org/id/ENSGALT00010048052.1" }, { "database": "Ensembl Peptide", "id": "ENSGALP00010028361.1", "url": "https://www.ensembl.org/id/ENSGALP00010028361.1" } ] } }, { "isoform_ac": "A0A8V0Z544-1", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PB24/entry#A0A8V0Z544-1", "sequence": { "sequence": "MAPPLLGCLVKWNRDVSMNNITRLPEDAFKNFPYLEELRLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPNEAIRGLSGLQSLRLDANHITAVPKDSFEGLVQLRHLWLDDNSLTEVPIHPLSNLPSLQALTLALNKITHIPDYAFTNLSSLVVLHLHNNKIKTIGKHCFDGLDNLETLDLNYNNMVEFPEAIKALPNLKELAFHSNYISIIPDGAFAGNPLLRMIHLYDNPLSFVGNSAFQNLSDLHSLVIRGASMVQWFPNLTGTVNLESLTLTGTKINSIPVNLCQEQKMLRTLDLSYNNIKDLPSFTGCRSLEEISLQHNQIHEITDDTFQGLSSLRILDLSRNRICKIHKEAFTTIGAIVNLDLSFNELTSVPTEGLSGLNQLKLAGNSELKEALAAQNFAKLRSLSVPYAYQCCAFWGCDSYLNSNAEDSSHQDQDAMGDREKTDADGLRNEENAELGQTIIHCTPAIGAFKPCEYLLGSWMIRLTVWFIFLVALFFNLLVMLTVFASCAPLPSSKLFIGLISVSNLFMGVYTGILTFLDAISWGRFAEFGIWWETGSGCRVAGFLAVFSSESAIFFLMLAAVERSFSAKEIIKKGKSNHQKQFQIAAVLAFLCAVVAGCLPLFHKAEYSASPLCLPFPTGETPSLGFTVTLVLLNSLAFLLMAIIYTKLYCNLEKEDLSENSQSCMIKHVAWLIFTNCIFFCPVAFFSFAPLITAISISPEIMKSVTLIFFPLPACLNPVLYVFFNPKFKEDWKLLRRQVTRKNGVVAISISAQGGCATQDFYYDCGMYTHLQGNVAMCECCESLLLSKPVPCKHLIKSHSCPTLAVVPCQRPDGYWSDCGTQSAHSDYADEDDSFVSDSSDQVQACGRACFYQSRGFPLVRYAYNINIPRIKD", "length": 904, "header": "tr|A0A8V0Z544-1|A0A8V0Z544_CHICK Computationally mapped isoform of Leucine rich repeat containing G protein-coupled receptor 4 OS=Gallus gallus OX=9031 GN=LGR4 PE=4 SV=1 CANONICAL=A0A1D5PB24-1" }, "locus": { "chromosome": "5", "start_pos": 3895309, "end_pos": 3837132, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSGALT00010048038.1", "url": "https://www.ensembl.org/id/ENSGALT00010048038.1" }, { "database": "Ensembl Peptide", "id": "ENSGALP00010028355.1", "url": "https://www.ensembl.org/id/ENSGALP00010028355.1" } ] } }, { "isoform_ac": "A0A8V0ZBS3-1", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PB24/entry#A0A8V0ZBS3-1", "sequence": { "sequence": "MRCLALLGLVAWGLGSSAGPSGGASPPPCPASCSCDGDRGVDCSGRGLAAVPPGLSAFTQALDVSMNNITRLPEDAFKNFPYLEELRLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPNEAIRGLSGLQSLRLDANHITAVPKDSFEGLVQLRHLWLDDNSLTEVPIHPLSNLPSLQALTLALNKITHIPDYAFTNLSSLVVLDLNYNNMVEFPEAIKALPNLKELAFHSNYISIIPDGAFAGNPLLRMIHLYDNPLSFVGNSAFQNLSDLHSLVIRGASMVQWFPNLTGTVNLESLTLTGTKINSIPVNLCQEQKMLRTLDLSYNNIKDLPSFTGCRSLEEISLQHNQIHEITDDTFQGLSSLRILDLSRNRICKIHKEAFTTIGAIVNLDLSFNELTSVPTEGLSGLNQLKLAGNSELKEALAAQNFAKLRSLSVPYAYQCCAFWGCDSYLNSNAEDSSHQDQDAMGDREKTDADGLRNEENAELGQTIIHCTPAIGAFKPCEYLLGSWMIRLTVWFIFLVALFFNLLVMLTVFASCAPLPSSKLFIGLISVSNLFMGVYTGILTFLDAISWGRFAEFGIWWETGSGCRVAGFLAVFSSESAIFFLMLAAVERSFSAKEIIKKGKSNHQKQFQIAAVLAFLCAVVAGCLPLFHKAEYSASPLCLPFPTGETPSLGFTVTLVLLNSLAFLLMAIIYTKLYCNLEKEDLSENSQSCMIKHVAWLIFTNCIFFCPVAFFSFAPLITAISISPEIMKSVTLIFFPLPACLNPVLYVFFNPKFKEDWKLLRRQVTRKNGVVAISISAQGGCATQDFYYDCGMYTHLQGNVAMCECCESLLLSKPVPCKHLIKSHSCPTLAVVPCQRPDGYWSDCGTQSAHSDYADEDDSFVSDSSDQVQACGRACFYQSRGFPLVRYAYNINIPRIKD", "length": 928, "header": "tr|A0A8V0ZBS3-1|A0A1D5PB24_CHICK Computationally mapped isoform of Leucine rich repeat containing G protein-coupled receptor 4 OS=Gallus gallus OX=9031 GN=LGR4 PE=4 SV=1 CANONICAL=A0A1D5PB24-1" }, "locus": { "chromosome": "5", "start_pos": 3895607, "end_pos": 3837132, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSGALT00010048046.1", "url": "https://www.ensembl.org/id/ENSGALT00010048046.1" }, { "database": "Ensembl Peptide", "id": "ENSGALP00010028359.1", "url": "https://www.ensembl.org/id/ENSGALP00010028359.1" } ] } }, { "isoform_ac": "A0A8V0ZCD2-1", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PB24/entry#A0A8V0ZCD2-1", "sequence": { "sequence": "MDVSMNNITRLPEDAFKNFPYLEELRLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPNEAIRGLSGLQSLRLDANHITAVPKDSFEGLVQLRHLWLDDNSLTEVPIHPLSNLPSLQALTLALNKITHIPDYAFTNLSSLVVLHLHNNKIKTIGKHCFDGLDNLETLDLNYNNMVEFPEAIKALPNLKELAFHSNYISIIPDGAFAGNPLLRMIHLYDNPLSFVGNSAFQNLSDLHSLVIRGASMVQWFPNLTGTVNLESLTLTGTKINSIPVNLCQEQKMLRTLDLSYNNIKDLPSFTGCRSLEEISLQHNQIHEITDDTFQGLSSLRILDLSRNRICKIHKEAFTTIGAIVNLDLSFNELTSVPTEGLSGLNQLKLAGNSELKEALAAQNFAKLRSLSVPYAYQCCAFWGCDSYLNSNAEDSSHQDQDAMGDREKTDADGLRNEENAELGQTIIHCTPAIGAFKPCEYLLGSWMIRLTVWFIFLVALFFNLLVMLTVFASCAPLPSSKLFIGLISVSNLFMGVYTGILTFLDAISWGRFAEFGIWWETGSGCRVAGFLAVFSSESAIFFLMLAAVERSFSAKEIIKKGKSNHQKQFQIAAVLAFLCAVVAGCLPLFHKAEYSASPLCLPFPTGETPSLGFTVTLVLLNSLAFLLMAIIYTKLYCNLEKEDLSENSQSCMIKHVAWLIFTNCIFFCPVAFFSFAPLITAISISPEIMKSVTLIFFPLPACLNPVLYVFFNPKFKEDWKLLRRQVTRKNGVVAISISAQGGCATQDFYYDCGMYTHLQGNVAMCECCESLLLSKPVPCKHLIKSHSCPTLAVVPCQRPDGYWSDCGTQSAHSDYADEDDSFVSDSSDQVQACGRACFYQSRGFPLVRYAYNINIPRIKD", "length": 891, "header": "tr|A0A8V0ZCD2-1|A0A1D5PB24_CHICK Computationally mapped isoform of Leucine rich repeat containing G protein-coupled receptor 4 OS=Gallus gallus OX=9031 GN=LGR4 PE=4 SV=1 CANONICAL=A0A1D5PB24-1" }, "locus": { "chromosome": "5", "start_pos": 3874871, "end_pos": 3837132, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSGALT00010048015.1", "url": "https://www.ensembl.org/id/ENSGALT00010048015.1" }, { "database": "Ensembl Peptide", "id": "ENSGALP00010028343.1", "url": "https://www.ensembl.org/id/ENSGALP00010028343.1" } ] } }, { "isoform_ac": "A0A8V0ZID2-1", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PB24/entry#A0A8V0ZID2-1", "sequence": { "sequence": "MWCAGELRSQQQMGDVSMNNITRLPEDAFKNFPYLEELRLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPNEAIRGLSGLQSLRLDANHITAVPKDSFEGLVQLRHLWLDDNSLTEVPIHPLSNLPSLQALTLALNKITHIPDYAFTNLSSLVVLHLHNNKIKTIGKHCFDGLDNLETLDLNYNNMVEFPEAIKALPNLKELAFHSNYISIIPDGAFAGNPLLRMIHLYDNPLSFVGNSAFQNLSDLHSLVIRGASMVQWFPNLTGTVNLESLTLTGTKINSIPVNLCQEQKMLRTLDLSYNNIKDLPSFTGCRSLEEISLQHNQIHEITDDTFQGLSSLRILDLSRNRICKIHKEAFTTIGAIVNLDLSFNELTSVPTEGLSGLNQLKLAGNSELKEALAAQNFAKLRSLSVPYAYQCCAFWGCDSYLNSNAEDSSHQDQDAMGDREKTDADGLRNEENAELGQTIIHCTPAIGAFKPCEYLLGSWMIRLTVWFIFLVALFFNLLVMLTVFASCAPLPSSKLFIGLISVSNLFMGVYTGILTFLDAISWGRFAEFGIWWETGSGCRVAGFLAVFSSESAIFFLMLAAVERSFSAKEIIKKGKSNHQKQFQIAAVLAFLCAVVAGCLPLFHKAEYSASPLCLPFPTGETPSLGFTVTLVLLNSLAFLLMAIIYTKLYCNLEKEDLSENSQSCMIKHVAWLIFTNCIFFCPVAFFSFAPLITAISISPEIMKSVTLIFFPLPACLNPVLYVFFNPKFKEDWKLLRRQVTRKNGVVAISISAQGGCATQDFYYDCGMYTHLQGNVAMCECCESLLLSKPVPCKHLIKSHSCPTLAVVPCQRPDGYWSDCGTQSAHSDYADEDDSFVSDSSDQVQACGRACFYQSRGFPLVRYAYNINIPRIKD", "length": 904, "header": "tr|A0A8V0ZID2-1|A0A8V0ZID2_CHICK Computationally mapped isoform of Leucine rich repeat containing G protein-coupled receptor 4 OS=Gallus gallus OX=9031 GN=LGR4 PE=4 SV=1 CANONICAL=A0A1D5PB24-1" }, "locus": { "chromosome": "5", "start_pos": 3875942, "end_pos": 3837132, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSGALT00010048029.1", "url": "https://www.ensembl.org/id/ENSGALT00010048029.1" }, { "database": "Ensembl Peptide", "id": "ENSGALP00010028351.1", "url": "https://www.ensembl.org/id/ENSGALP00010028351.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "gga:428605", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?gga:428605", "resource": "KEGG Pathway" }, { "id": "R-GGA-4641263", "name": "Regulation of FZD by ubiquitination", "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-4641263", "resource": "Reactome", "description": "Regulation of FZD by ubiquitination" } ], "orthologs": [ { "uniprot_canonical_ac": "A2ARI4-1", "protein_name": "Leucine-rich repeat-containing G-protein coupled receptor 4", "gene_name": "Lgr4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPGPLRLLCFFALGLLGSAGPSGAAPPLCAAPCSCDGDRRVDCSGKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNILTEVPVRPLSNLPTLQALTLALNNISSIPDFAFTNLSSLVVLHLHNNKIKSLSQHCFDGLDNLETLDLNYNNLDEFPQAIKALPSLKELGFHSNSISVIPDGAFAGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASLVQWFPNLAGTVHLESLTLTGTKISSIPDDLCQNQKMLRTLDLSYNDIRDLPSFNGCRALEEISLQRNQISLIKETTFQGLTSLRILDLSRNLIREIHSGAFAKLGTITNLDVSFNELTSFPTEGLNGLNQLKLVGNFQLKDALAARDFANLRSLSVPYAYQCCAFWGCDSYANLNTEDNSPQDHSVTKEKGATDAANATSTAESEEHSQIIIHCTPSTGAFKPCEYLLGSWMIRLTVWFIFLVALLFNLLVILTVFASCSSLPASKLFIGLISVSNLLMGIYTGILTFLDAVSWGRFAEFGIWWETGSGCKVAGSLAVFSSESAVFLLTLAAVERSVFAKDVMKNGKSSHLRQFQVAALVALLGAAIAGCFPLFHGGQYSASPLCLPFPTGETPSLGFTVTLVLLNSLAFLLMAIIYTKLYCNLEKEDPSENSQSSMIKHVAWLIFTNCIFFCPVAFFSFAPLITAISISPEIMKSVTLIFFPLPACLNPVLYVFFNPKFKDDWKLLKRRVTRKHGSVSVSISSQGGCGEQDFYYDCGMYSHLQGNLTVCDCCESFLLTKPVSCKHLIKSHSCPVLTVASCQRPEAYWSDCGTQSAHSDYADEEDSFVSDSSDQVQACGRACFYQSRGFPLVRYAYNLPRVRD", "length": 951 }, "evidence": [ { "id": "A0A1D5PB24", "url": "https://omabrowser.org/oma/group/A0A1D5PB24/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "F1MLX5-1", "protein_name": "Leucine-rich repeat-containing G-protein coupled receptor 4", "gene_name": "LGR4", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MPGPLGLLCFLALGLRGSAEPSGAAPPLCAAPCSCDGDRRVDCSGKGLTAVPEGLSAFTQLLDISMNNITQLPEDAFKNFPFLEELRLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSSLQSLRLDANHITSVPEDSFEGLTQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIKSLGQHCFDGLDNLETLDLNYNNLGEFPQAIKALPSLKELLFHSNSISVIPDGAFDGNPLLKTIHLYDNPLSFVGNSAFHNLSELHSLVIRGASMVQRFPNLTGTVRLESLTLTGTKISSISNNLCQEQKRLRTLDLSYNSIKDLPSFNGCHALEEISLQRNQIHQIKEDTFQGLTSLKILDLSRNLIHEIDDRAFAKLGSITNLDVSFNELTSFPTEGLNGLNQLKLVGNFKLKEALAAKDFVNLRSLSVPYAYQCCAFWGCDSYTHSNTEDNSLQDHSGSKDKGLSDVAGVTSSAENEEHSQIIIHCTPSTGAFKPCEYLLGSWMIRLTVWFIFLVALFFNLLVILTTFASCTSVPSSKLFIGLISVSNLFMGAYTGILTFLDAVSWGRFAEFGIWWEIGSGCKIAGFLAVFSSESAIFLLMLAAVERSLSAKDMMKNGKSNHLRQFRIAALLAFLGAAVAGSFPLFHRGEYSASPLCLPFPTGETPSLGFTVTLVLLNSLAFLLMAIIYTKLYCNLEKEDLSESSQSSMIKHVAWLIFTNCIFFCPVAFFSFAPLITAVSISPEIMKSVTLIFFPLPACLNPVLYVFFNPKFKEDWKLLKRHVSKKSGSASVSISSQAGCVEQDFYYDCGMYSHLQGNLTVCDCCEAFLLTKPVSCKHLIKSHSCPALTVGSCQRPDGYWSDCGTQSAHSDYADEEDSFVSDSSDQVQACGRACFYQSRGFPLVRYAYNLPRVKD", "length": 951 }, "evidence": [ { "id": "A0A1D5PB24", "url": "https://omabrowser.org/oma/group/A0A1D5PB24/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "F1SGM5-1", "protein_name": "Leucine rich repeat containing G protein-coupled receptor 4", "gene_name": "LGR4", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MPGPLGLLCFLALGLRCSAEPSGAAPSLCSAPCSCDGDRRVDCSGKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKNFPFLEELRLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLTQLRHLWLDDNSLTEVPVQPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIKSLGQHCFDGLDNLETLDLNYNNLGEFPQAIKALPSLKELLFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQRFPNLTGTVHLESLTLTGTKISSISSNLCQEQKMLRTLDLSYNNIKDLPSFNGCYALEEISLQRNQIHQIKEGTFQGLTSLRILDLSRNLIHEIHDRAFAKLGSITNLDISFNELTSFPTEGLNGLNQLKLVGNFKLKEALAAKDFVNLRSLSVPYAYQCCAFWGCDSYAHSNTDDNSLQDYSVAKEKGSTDGTGVTSSVDNEEHSQIIIHCTPSTGAFKPCEYLLGSWMIRLTVWFIFLVALFFNLLVILTTFASCTSLPSSKLFIGLISVSNLFMGAYTGILTFLDAVSWGRFAEFGIWWEIGSGCKIAGFLAVFSSESAIFLLMLAAVERSLSAKDIMKNGKSDHLKQFQIAAFFAFLGAAVAGCFPLFHGGEYSASPLCLPFPTGETPSLGFTVTLVLLNSLAFLLMAIIYTKLYCNLEKEDLSENSHSSMIKHVAWLIFTNCIFFCPVAFFSFAPLITAISISPEIMKSVTLIFFPLPACLNPVLYVFFNPKFKEDWKLLKRHITKKSGSVSVSTSSQAGCVDQDFYYDCGMYSHLQGNLSVCDCCESFLLTKPVSCKHLIKSHSCPALAVGSCQRPDGYWSDCGTQSAHSDYADEEDSFVSDSSDQVQACGRACFYQSRGFPLVRYAYNLPRVKD", "length": 951 }, "evidence": [ { "id": "A0A1D5PB24", "url": "https://omabrowser.org/oma/group/A0A1D5PB24/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q9BXB1-1", "protein_name": "Leucine-rich repeat-containing G-protein coupled receptor 4", "gene_name": "LGR4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPGPLGLLCFLALGLLGSAGPSGAAPPLCAAPCSCDGDRRVDCSGKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEFPQAIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLPSFNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDVSFNELTSFPTEGLNGLNQLKLVGNFKLKEALAAKDFVNLRSLSVPYAYQCCAFWGCDSYANLNTEDNSLQDHSVAQEKGTADAANVTSTLENEEHSQIIIHCTPSTGAFKPCEYLLGSWMIRLTVWFIFLVALFFNLLVILTTFASCTSLPSSKLFIGLISVSNLFMGIYTGILTFLDAVSWGRFAEFGIWWETGSGCKVAGFLAVFSSESAIFLLMLATVERSLSAKDIMKNGKSNHLKQFRVAALLAFLGATVAGCFPLFHRGEYSASPLCLPFPTGETPSLGFTVTLVLLNSLAFLLMAVIYTKLYCNLEKEDLSENSQSSMIKHVAWLIFTNCIFFCPVAFFSFAPLITAISISPEIMKSVTLIFFPLPACLNPVLYVFFNPKFKEDWKLLKRRVTKKSGSVSVSISSQGGCLEQDFYYDCGMYSHLQGNLTVCDCCESFLLTKPVSCKHLIKSHSCPALAVASCQRPEGYWSDCGTQSAHSDYADEEDSFVSDSSDQVQACGRACFYQSRGFPLVRYAYNLPRVKD", "length": 951 }, "evidence": [ { "id": "A0A1D5PB24", "url": "https://omabrowser.org/oma/group/A0A1D5PB24/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9Z2H4-1", "protein_name": "Leucine-rich repeat-containing G-protein coupled receptor 4", "gene_name": "Lgr4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPGPLRLLCFFALGLLGSAGPSGAAPPLCAAPCSCDGDRRVDCSGKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKSFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLRTVPSEAIHGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVRPLSNLPTLQALTLALNNISSIPDFAFTNLSSLVVLHLHNNKIKSLSQHCFDGLDNLETLDLNYNNLDEFPQAIKALPSLKELGFHSNSISVIPDGAFGGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASLVQWFPNLTGTVHLESLTLTGTKISSIPDDLCQNQKMLRTLDLSYNNIRDLPSFNGCRALEEISLQRNQISLIKENTFQGLTSLRILDLSRNLIREIHSGAFAKLGTITNLDVSFNELTSFPTEGLNGLNQLKLVGNFKLKDALAARDFANLRSLSVPYAYQCCAFWGCDSYANLNTEDNSPQEHSVTKEKGATDAANVTSTAENEEHSQIIIHCTPSTGAFKPCEYLLGSWMIRLTVWFIFLVALLFNLLVILTVFASCSSLPASKLFIGLISVSNLLMGIYTGILTFLDAVSWGRFAEFGIWWETGSGCKVAGSLAVFSSESAVFLLTLAAVERSVFAKDLMKHGKSSHLRQFQVAALLALLGAAVAGCFPLFHGGQYSASPLCLPFPTGETPSLGFTVTLVLLNSLAFLLMAIIYTKLYCNLEKEDLSENSQSSVIKHVAWLIFTNCIFFCPVAFFSFAPLITAISISPEIMKSVTLIFFPLPACLNPVLYVFFNPKFKEDWKLLKRRVTRKHGSVSVSISSQGGCGEQDFYYDCGMYSHLQGNLTVCDCCESFLLTKPVSCKHLIKSHSCPVLTAASCQRPEAYWSDCGTQSAHSDYADEEDSFVSDSSDQVQACGRACFYQSRGFPLVRYAYNLQRVRD", "length": 951 }, "evidence": [ { "id": "A0A1D5PB24", "url": "https://omabrowser.org/oma/group/A0A1D5PB24/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "protein-hormone receptor activity", "id": "GO:0016500", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016500", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PB24", "url": "https://www.uniprot.org/uniprot/A0A1D5PB24" } ], "pmid": "" }, { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PB24", "url": "https://www.uniprot.org/uniprot/A0A1D5PB24" } ], "pmid": "" }, { "name": "G protein-coupled peptide receptor activity", "id": "GO:0008528", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008528", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PB24", "url": "https://www.uniprot.org/uniprot/A0A1D5PB24" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PB24", "url": "https://www.uniprot.org/uniprot/A0A1D5PB24" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 17, "go_terms": [ { "name": "adenylate cyclase-activating G protein-coupled receptor signaling pathway", "id": "GO:0007189", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007189", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PB24", "url": "https://www.uniprot.org/uniprot/A0A1D5PB24" } ], "pmid": "" }, { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PB24", "url": "https://www.uniprot.org/uniprot/A0A1D5PB24" } ], "pmid": "" }, { "name": "bone remodeling", "id": "GO:0046849", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046849", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PB24", "url": "https://www.uniprot.org/uniprot/A0A1D5PB24" } ], "pmid": "" }, { "name": "positive regulation of branching involved in ureteric bud morphogenesis", "id": "GO:0090190", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090190", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PB24", "url": "https://www.uniprot.org/uniprot/A0A1D5PB24" } ], "pmid": "" }, { "name": "positive regulation of canonical Wnt signaling pathway", "id": "GO:0090263", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090263", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PB24", "url": "https://www.uniprot.org/uniprot/A0A1D5PB24" } ], "pmid": "" }, { "name": "osteoblast differentiation", "id": "GO:0001649", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001649", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PB24", "url": "https://www.uniprot.org/uniprot/A0A1D5PB24" } ], "pmid": "" }, { "name": "digestive tract development", "id": "GO:0048565", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048565", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PB24", "url": "https://www.uniprot.org/uniprot/A0A1D5PB24" } ], "pmid": "" }, { "name": "circadian regulation of gene expression", "id": "GO:0032922", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032922", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PB24", "url": "https://www.uniprot.org/uniprot/A0A1D5PB24" } ], "pmid": "" }, { "name": "negative regulation of toll-like receptor signaling pathway", "id": "GO:0034122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034122", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PB24", "url": "https://www.uniprot.org/uniprot/A0A1D5PB24" } ], "pmid": "" }, { "name": "male genitalia development", "id": "GO:0030539", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030539", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PB24", "url": "https://www.uniprot.org/uniprot/A0A1D5PB24" } ], "pmid": "" }, { "name": "bone mineralization", "id": "GO:0030282", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030282", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PB24", "url": "https://www.uniprot.org/uniprot/A0A1D5PB24" } ], "pmid": "" }, { "name": "negative regulation of cytokine production", "id": "GO:0001818", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001818", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PB24", "url": "https://www.uniprot.org/uniprot/A0A1D5PB24" } ], "pmid": "" }, { "name": "metanephric glomerulus development", "id": "GO:0072224", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072224", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PB24", "url": "https://www.uniprot.org/uniprot/A0A1D5PB24" } ], "pmid": "" }, { "name": "intestinal stem cell homeostasis", "id": "GO:0036335", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036335", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PB24", "url": "https://www.uniprot.org/uniprot/A0A1D5PB24" } ], "pmid": "" }, { "name": "epithelial cell proliferation involved in renal tubule morphogenesis", "id": "GO:2001013", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001013", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PB24", "url": "https://www.uniprot.org/uniprot/A0A1D5PB24" } ], "pmid": "" }, { "name": "negative regulation of cold-induced thermogenesis", "id": "GO:0120163", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120163", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PB24", "url": "https://www.uniprot.org/uniprot/A0A1D5PB24" } ], "pmid": "" }, { "name": "metanephric nephron tubule morphogenesis", "id": "GO:0072282", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072282", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PB24", "url": "https://www.uniprot.org/uniprot/A0A1D5PB24" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 199, "end_pos": 201, "annotation": "n_glycosylation_sequon" }, { "start_pos": 294, "end_pos": 296, "annotation": "n_glycosylation_sequon" }, { "start_pos": 314, "end_pos": 316, "annotation": "n_glycosylation_sequon" }, { "start_pos": 68, "end_pos": 70, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A1D5PB24-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 952, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A1D5PB24-F1.pdb" } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], 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