{
    "uniprot_canonical_ac": "A0A1D5P3F4-1",
    "uniprot_ac": "A0A1D5P3F4",
    "uniprot_id": "A0A1D5P3F4_CHICK",
    "mass": {
        "chemical_mass": 44722.0,
        "monoisotopic_mass": 44722.0
    },
    "refseq": {},
    "gene_names": [
        {
            "name": "TRHR",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A0A1D5P3F4",
            "id": "A0A1D5P3F4"
        }
    ],
    "protein_names": [
        {
            "name": "Thyrotropin-releasing hormone receptor",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprotkb/A0A1D5P3F4/entry#names_and_taxonomy",
            "id": "A0A1D5P3F4"
        },
        {
            "name": "Thyroliberin receptor",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprotkb/A0A1D5P3F4/entry#names_and_taxonomy",
            "id": "A0A1D5P3F4"
        }
    ],
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        {
            "annotation": "Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway.",
            "evidence": [
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                    "database": "UniProtKB",
                    "id": "A0A1D5P3F4",
                    "url": "https://www.uniprot.org/uniprot/A0A1D5P3F4#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "ARBA00004100",
                    "url": "https://www.uniprot.org/uniprot/ARBA00004100#function"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Gallus gallus",
            "taxid": 9031,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A1D5P3F4",
                    "url": "https://www.uniprot.org/uniprot/A0A1D5P3F4"
                }
            ],
            "common_name": "Chicken",
            "glygen_name": "Chicken",
            "reference_species": "Gallus gallus [9031]"
        }
    ],
    "gene": [
        {
            "name": "TRHR",
            "url": "https://www.uniprot.org/uniprot/A0A1D5P3F4",
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                "end_pos": 131482009,
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                "evidence": [
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                        "database": "Ensembl Gene",
                        "id": "ENSGALG00010007990",
                        "url": "https://www.ensembl.org/id/ENSGALG00010007990"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "A0A1D5P3F4",
            "url": "https://alphafold.ebi.ac.uk/entry/A0A1D5P3F4",
            "database": "AlphaFoldDB",
            "categories": []
        },
        {
            "id": "cd14995",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14995",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR000276",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR002120",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR002120",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR017452",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR46061",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46061",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR46061:SF2",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46061:SF2",
            "database": "PANTHER",
            "categories": [
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            ]
        },
        {
            "id": "PF00001",
            "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00001",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-GGA-375276",
            "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-375276",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-GGA-416476",
            "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-416476",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "A0A1D5P3F4",
            "url": "https://www.uniprot.org/uniprot/A0A1D5P3F4",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A1D5P3F4-1",
            "url": "https://www.uniprot.org/uniprot/A0A1D5P3F4-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MENGTGDEQNHTGLLLSSQEIVTAEYQVVTILLVLLICGLGIVGNIMVVLVVLRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITESLYKSWVYGYVGCLCITYLQYLGINASSFSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWSFTSVYCMLWFFLLDLNIAVYKDTTVVSCGYKVSRSYYSPIYMMDFGIFYVLPMVLATVLYGLIARILFLNPIPSDPKENSNTWRNDMAQQNKTVNSKMTNKSFNSTIASRRQVTKMLAVVVVLFAFLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCHLKRDKKPANYSVALNYNVIKESDHFSSEIEDITVTNTYLSSAKTSIGDTCLSSEA",
        "length": 395,
        "header": "tr|A0A1D5P3F4-1|A0A1D5P3F4_CHICK Isoform 1 of Thyrotropin-releasing hormone receptor  OS=Gallus gallus OX=9031 GN=TRHR PE=3 SV=2 CANONICAL=A0A1D5P3F4-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A1D5P3F4-1",
            "url": "https://www.uniprot.org/uniprotkb/A0A1D5P3F4/entry#A0A1D5P3F4-1",
            "sequence": {
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                "length": 395,
                "header": "tr|A0A1D5P3F4-1|A0A1D5P3F4_CHICK Isoform 1 of Thyrotropin-releasing hormone receptor  OS=Gallus gallus OX=9031 GN=TRHR PE=3 SV=2 CANONICAL=A0A1D5P3F4-1"
            },
            "locus": {
                "chromosome": "2",
                "start_pos": 131496948,
                "end_pos": 131482436,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSGALT00010019043.1",
                        "url": "https://www.ensembl.org/id/ENSGALT00010019043.1"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSGALP00010010592.1",
                        "url": "https://www.ensembl.org/id/ENSGALP00010010592.1"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [],
    "pathway": [
        {
            "id": "R-GGA-375276",
            "name": "Peptide ligand-binding receptors",
            "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-375276",
            "resource": "Reactome",
            "description": "Peptide ligand-binding receptors"
        },
        {
            "id": "R-GGA-416476",
            "name": "G alpha (q) signalling events",
            "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-416476",
            "resource": "Reactome",
            "description": "G alpha (q) signalling events"
        }
    ],
    "orthologs": [],
    "go_annotation": {
        "categories": [
            {
                "name": "Cellular Component",
                "total": 1,
                "go_terms": [
                    {
                        "name": "plasma membrane",
                        "id": "GO:0005886",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886",
                        "evidence": [
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                                "database": "UniProtKB",
                                "id": "A0A1D5P3F4",
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                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 1,
                "go_terms": [
                    {
                        "name": "phospholipase C-activating G protein-coupled receptor signaling pathway",
                        "id": "GO:0007200",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007200",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1D5P3F4",
                                "url": "https://www.uniprot.org/uniprot/A0A1D5P3F4"
                            }
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                    }
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                "go_terms": [
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                        "name": "thyrotropin-releasing hormone receptor activity",
                        "id": "GO:0004997",
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                                "database": "UniProtKB",
                                "id": "A0A1D5P3F4",
                                "url": "https://www.uniprot.org/uniprot/A0A1D5P3F4"
                            }
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    "ptm_annotation": [],
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            "pdb_id": "AF-A0A1D5P3F4-F1",
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