{ "uniprot_canonical_ac": "A0A140T896-1", "uniprot_ac": "A0A140T896", "uniprot_id": "A0A140T896_BOVIN", "mass": { "chemical_mass": 52969.0, "monoisotopic_mass": 52969.0 }, "refseq": {}, "gene_names": [ { "name": "SHMT1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A140T896", "id": "A0A140T896" } ], "protein_names": [ { "name": "Serine hydroxymethyltransferase", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A140T896/entry#names_and_taxonomy", "id": "A0A140T896" }, { "name": "2.1.2.1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A140T896/entry#names_and_taxonomy", "id": "A0A140T896" } ], "function": [ { "annotation": "Interconversion of serine and glycine.", "evidence": [ { "database": "UniProtKB", "id": "A0A140T896", "url": "https://www.uniprot.org/uniprot/A0A140T896#function" }, { "database": "UniProtKB", "id": "RU000585", "url": "https://www.uniprot.org/uniprot/RU000585#function" }, { "database": "UniProtKB", "id": "A0AAA9TCG0", "url": "https://www.uniprot.org/uniprot/A0AAA9TCG0#function" }, { "database": "UniProtKB", "id": "A0A3Q1LKF4", "url": "https://www.uniprot.org/uniprot/A0A3Q1LKF4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A140T896", "url": "https://www.uniprot.org/uniprot/A0A140T896" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SHMT1", "url": "https://www.uniprot.org/uniprot/A0A140T896", "locus": { "chromosome": "19", "start_pos": 34350203, "end_pos": 34335014, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017094", "url": "https://www.ensembl.org/id/ENSBTAG00000017094" } ] } } ], "crossref": [ { "id": "A0A140T896", "url": "https://alphafold.ebi.ac.uk/entry/A0A140T896", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017094", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017094", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00378", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00378", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001085", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001085", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015421", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015421", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015422", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015422", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015424", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015424", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019798", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019798", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039429", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039429", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "HGMALNM", "url": "https://omabrowser.org/oma/group/HGMALNM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A140T896", "url": "https://www.orthodb.org/?gene=A0A140T896", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11680", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11680", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11680:SF35", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11680:SF35", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00464", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00464", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "R-BTA-196757", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-196757", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-BTA-71262", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-71262", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "XP_005220393", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005220393", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "15481", "url": "https://www.rhea-db.org/rhea/15481", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A140T896", "url": "https://www.uniprot.org/uniprot/A0A140T896", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A140T896-1", "url": "https://www.uniprot.org/uniprot/A0A140T896-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LKF4", "url": "https://www.uniprot.org/uniprot/A0A3Q1LKF4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LKF4-1", "url": "https://www.uniprot.org/uniprot/A0A3Q1LKF4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCG0", "url": "https://www.uniprot.org/uniprot/A0AAA9TCG0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCG0-1", "url": "https://www.uniprot.org/uniprot/A0AAA9TCG0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAPVNKAPRDANLWSLHEKMLAQPLKDNDVEVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGYPGQRYYGGTEFIDELEVLCQKRALQVYGLDSQCWGVNVQPYSGSPANFAVYTALVEPHGRIMGLDLPDGGHLTHGFMTDKKKISATSIFFESMPYKVNPDTGYINYDQLEENARLFHPRLIIAGTSCYSRNLDYARLRKIADDNGAYLMADMAHVSGLVAAGVVPSPFEHCHVVSTTTHKTLRGCRAGMIFYRKGVRSVDPKTGRETRYNLESLINSAVFPGLQGGPHNHAIAGVAVALKQAMTPEFRAYQRQVVANCRALAEALMGLGYRVVTGGSDNHLILVDLRSKGTDGGRAEKVLEACSIACNKNTCPGDKSALRPSGLRLGTPALTSRGLLEEDFQKVAHFIHRGIELTLQIQDAVGVKATLKEFMEKLAGAEEHQRAVAALRAEVESFATLFPLPGLPGF", "length": 484, "header": "tr|A0A140T896-1|A0A140T896_BOVIN Isoform 1 of Serine hydroxymethyltransferase OS=Bos taurus OX=9913 GN=SHMT1 PE=3 SV=1 CANONICAL=A0A140T896-1" }, "isoforms": [ { "isoform_ac": "A0A140T896-1", "url": "https://www.uniprot.org/uniprotkb/A0A140T896/entry#A0A140T896-1", "sequence": { "sequence": "MAAPVNKAPRDANLWSLHEKMLAQPLKDNDVEVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGYPGQRYYGGTEFIDELEVLCQKRALQVYGLDSQCWGVNVQPYSGSPANFAVYTALVEPHGRIMGLDLPDGGHLTHGFMTDKKKISATSIFFESMPYKVNPDTGYINYDQLEENARLFHPRLIIAGTSCYSRNLDYARLRKIADDNGAYLMADMAHVSGLVAAGVVPSPFEHCHVVSTTTHKTLRGCRAGMIFYRKGVRSVDPKTGRETRYNLESLINSAVFPGLQGGPHNHAIAGVAVALKQAMTPEFRAYQRQVVANCRALAEALMGLGYRVVTGGSDNHLILVDLRSKGTDGGRAEKVLEACSIACNKNTCPGDKSALRPSGLRLGTPALTSRGLLEEDFQKVAHFIHRGIELTLQIQDAVGVKATLKEFMEKLAGAEEHQRAVAALRAEVESFATLFPLPGLPGF", "length": 484, "header": "tr|A0A140T896-1|A0A140T896_BOVIN Isoform 1 of Serine hydroxymethyltransferase OS=Bos taurus OX=9913 GN=SHMT1 PE=3 SV=1 CANONICAL=A0A140T896-1" }, "locus": { "chromosome": "19", "start_pos": 34349258, "end_pos": 34340949, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022732.7", "url": "https://www.ensembl.org/id/ENSBTAT00000022732.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022732.5", "url": "https://www.ensembl.org/id/ENSBTAP00000022732.5" } ] } }, { "isoform_ac": "A0A3Q1LKF4-1", "url": "https://www.uniprot.org/uniprotkb/A0A140T896/entry#A0A3Q1LKF4-1", "sequence": { "sequence": "MAAPVNKAPRDANLWSLHEKMLAQPLKDNDVEVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGYPGQRYYGGTEFIDELEVLCQKRALQVYGLDSQCWGVNVQPYSGNGQVQTSLGGPLPASLLGLPGKESISRTPCQMGEMRSPPSPSTVNPDTGYINYDQLEENARLFHPRLIIAGTSCYSRNLDYARLRKIADDNGAYLMADMAHVSGLVAAGVVPSPFEHCHVVSTTTHKTLRGCRAGMIFYRKGVRSVDPKTGRETRYNLESLINSAVFPGLQGGPHNHAIAGVAVALKQAMTPEFRAYQRQVVANCRALAEALMGLGYRVVTGGSDNHLILVDLRSKGTDGGRAEKVLEACSIACNKNTCPGDKSALRPSGLRLGTPALTSRGLLEEDFQKVAHFIHRGIELTLQIQDAVGVKATLKEFMEKLAGAEEHQRAVAALRAEVESFATLFPLPGLPGF", "length": 474, "header": "tr|A0A3Q1LKF4-1|A0A140T896_BOVIN Computationally mapped isoform of Serine hydroxymethyltransferase OS=Bos taurus OX=9913 GN=SHMT1 PE=3 SV=1 CANONICAL=A0A140T896-1" }, "locus": { "chromosome": "19", "start_pos": 34349258, "end_pos": 34340949, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084693.2", "url": "https://www.ensembl.org/id/ENSBTAT00000084693.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057116.1", "url": "https://www.ensembl.org/id/ENSBTAP00000057116.1" } ] } }, { "isoform_ac": "A0AAA9TCG0-1", "url": "https://www.uniprot.org/uniprotkb/A0A140T896/entry#A0AAA9TCG0-1", "sequence": { "sequence": "MAAPVNKAPRDANLWSLHEKMLAQPLKDNDVEVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGYPGQRYYGGTEFIDELEVLCQKRALQVYGLDSQCWGVNVQPYSGSPANFAVYTALVEPHGRIMGLDLPDGGHLTHGFMTDKKKISATSIFFESMPYKVNPDTGYINYDQLEENARLFHPRLIIAGTSCYSRNLDYARLRKIADDNGAYLMADMAHVSGLVAAGVVPSPFEHCHVVSTTTHKTLRGCRAGMIFYRKGVAVALKQAMTPEFRAYQRQVVANCRALAEALMGLGYRVVTGGSDNHLILVDLRSKGTDGGRAEKVLEACSIACNKNTCPGDKSALRPSGLRLGTPALTSRGLLEEDFQKVAHFIHRGIELTLQIQDAVGVKATLKEFMEKLAGAEEHQRAVAALRAEVESFATLFPLPGLPGF", "length": 445, "header": "tr|A0AAA9TCG0-1|A0A140T896_BOVIN Computationally mapped isoform of Serine hydroxymethyltransferase OS=Bos taurus OX=9913 GN=SHMT1 PE=3 SV=1 CANONICAL=A0A140T896-1" }, "locus": { "chromosome": "19", "start_pos": 34349258, "end_pos": 34340949, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113136.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113136.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096351.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096351.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-BTA-196757", "name": "Metabolism of folate and pterines", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-196757", "resource": "Reactome", "description": "Metabolism of folate and pterines" }, { "id": "R-BTA-71262", "name": "Carnitine synthesis", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-71262", "resource": "Reactome", "description": "Carnitine synthesis" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZN35-1", "protein_name": "Serine hydroxymethyltransferase", "gene_name": "SHMT1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MATPDSGAPWDADLWSSHDKMLVQPLKDSDLEVYNIIKKESHRQRVGLELIASENFASRAVLEALGSCLNNKYSEGYPGQRYYGGTEFIDELELLCQRRALQVYGLDPQCWGVNVQPYSGSPANFAVYTALVEPHGRIMGLDLPDGGHLTHGFMTEKKKISATSIFFESMPYKVDPDTGYINYDRLEENARLFHPKLIIAGTSCYSRNLDYARLRRIADDNGAYLMADMAHISGLVAAGVVPSPFEHCHVVSTTTHKTLRGCRAGMIFYRKGVRSVDPKTGRETRYNLESLINSAVFPGLQGGPHNHAIAGVAVALKQAMTPEFRVYQCQVVANCRALAKTLMGLGYKVVTGGSDNHLILVDLRSKGTDGGRAEKVLEACNIACNKNTCPGDKSALRPSGLRLGTPALTSRGLLEEDFQEVARFIHRGIELTLQIQDAVGAKATLKEFTETLAGAGEHQRAVAALRAEVESFAALFPLPGLPDF", "length": 484 }, "evidence": [ { "id": "A0A140T896", "url": "https://omabrowser.org/oma/group/A0A140T896/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O23254-1", "protein_name": "Serine hydroxymethyltransferase 4", "gene_name": "SHM4", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MEPVSSWGNTSLVSVDPEIHDLIEKEKRRQCRGIELIASENFTSFAVIEALGSALTNKYSEGIPGNRYYGGNEFIDEIENLCRSRALEAFHCDPAAWGVNVQPYSGSPANFAAYTALLQPHDRIMGLDLPSGGHLTHGYYTSGGKKISATSIYFESLPYKVNFTTGYIDYDKLEEKALDFRPKLLICGGSAYPRDWDYARFRAIADKVGALLLCDMAHISGLVAAQEAANPFEYCDVVTTTTHKSLRGPRAGMIFYRKGPKPPKKGQPEGAVYDFEDKINFAVFPALQGGPHNHQIGALAVALKQANTPGFKVYAKQVKANAVALGNYLMSKGYQIVTNGTENHLVLWDLRPLGLTGNKVEKLCDLCSITLNKNAVFGDSSALAPGGVRIGAPAMTSRGLVEKDFEQIGEFLSRAVTLTLDIQKTYGKLLKDFNKGLVNNKDLDQLKADVEKFSASYEMPGFLMSEMKYKD", "length": 471 }, "evidence": [ { "id": "A0A140T896", "url": "https://omabrowser.org/oma/group/A0A140T896/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "P50431-1", "protein_name": "Serine hydroxymethyltransferase, cytosolic", "gene_name": "Shmt1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MADRDATLWASHEKMLSQPLKDSDAEVYSIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGYPGQRYYGGTEFIDELEMLCQKRALQAYHLDPQCWGVNVQPYSGSPANFAVYTALVEPHGRIMGLDLPDGGHLTHGFMTDKKKISATSIFFESMPYKVYPETGYINYDQLEENASLFHPKLIIAGTSCYSRNLDYARLRKIADDNGAYLMADMAHISGLVAAGVVPSPFEHCHVVTTTTHKTLRGCRAGMIFYRKGVRSVDPKTGKETYYELESLINSAVFPGLQGGPHNHAIAGVAVALKQAMTTEFKIYQLQVLANCRALSDALTELGYKIVTGGSDNHLILMDLRSKGTDGGRAEKVLEACSIACNKNTCPGDKSALRPSGLRLGTPALTSRGLLEEDFQKVAHFIHRGIELTLQIQSHMATKATLKEFKEKLAGDEKIQSAVATLREEVENFASNFSLPGLPDF", "length": 478 }, "evidence": [ { "id": "A0A140T896", "url": "https://omabrowser.org/oma/group/A0A140T896/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q54EW1-1", "protein_name": "Serine hydroxymethyltransferase 2", "gene_name": "shmt2", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MLKSLSKLTPSIRGVVSINRSFCTKKFLPTNRSVSESDPEIYDLMMKEKQRQFTGLELIASENFTSRAVMESIGSCFTNKYAEGLPGARYYGGNEVVDQLENLCIKRALETFNLNPEEWGVNVQPYSGSTANFAAFTGLLKPHDRIMGLDLPSGGHLTHGYQTDKKKISATSIFFESMPYQVNETGYVDYNKMEANAALFRPKLLIAGASAYPREWDYERMRKIADKHGAYLLCDMAHISGMVAGKQAISPFLFCDVVTTTTHKTLRGPRAGLIFFRKTKRRDAKGNIIDDDLENRINFAVFPSCQGGPHENTIAGIAVALKEASSPDFQEYTKQVRRNSQTMGEELKKRGYSLVTEGTDNHLVLWDLRPQGITGSKIEKACDEAHITVNKNAVYGDTNAIAPGGVRLGAPALTSRGLKEQDFVKVVDFLDRVVKISLDIQSKVGKKMPDFQRAIADNQDLKQIRQEVKEFSTKFGMPGEL", "length": 481 }, "evidence": [ { "id": "A0A140T896", "url": "https://omabrowser.org/oma/group/A0A140T896/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "pyridoxal phosphate binding", "id": "GO:0030170", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030170", "evidence": [ { "database": "UniProtKB", "id": "A0A140T896", "url": "https://www.uniprot.org/uniprot/A0A140T896" } ], "pmid": "" }, { "name": "glycine hydroxymethyltransferase activity", "id": "GO:0004372", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004372", "evidence": [ { "database": "UniProtKB", "id": "A0A140T896", "url": "https://www.uniprot.org/uniprot/A0A140T896" } ], "pmid": "" }, { "name": "mRNA regulatory element binding translation repressor activity", "id": "GO:0000900", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000900", "evidence": [ { "database": "UniProtKB", "id": "A0A140T896", "url": "https://www.uniprot.org/uniprot/A0A140T896" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "A0A140T896", "url": "https://www.uniprot.org/uniprot/A0A140T896" } ], "pmid": "" }, { "name": "mRNA 5'-UTR binding", "id": "GO:0048027", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048027", "evidence": [ { "database": "UniProtKB", "id": "A0A140T896", "url": "https://www.uniprot.org/uniprot/A0A140T896" } ], "pmid": "" }, { "name": "serine binding", "id": "GO:0070905", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070905", "evidence": [ { "database": "UniProtKB", "id": "A0A140T896", "url": "https://www.uniprot.org/uniprot/A0A140T896" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "tetrahydrofolate interconversion", "id": "GO:0035999", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035999", "evidence": [ { "database": "UniProtKB", "id": "A0A140T896", "url": "https://www.uniprot.org/uniprot/A0A140T896" } ], "pmid": "" }, { "name": "glycine biosynthetic process from serine", "id": "GO:0019264", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019264", "evidence": [ { "database": "UniProtKB", "id": "A0A140T896", "url": "https://www.uniprot.org/uniprot/A0A140T896" } ], "pmid": "" }, { "name": "protein homotetramerization", "id": "GO:0051289", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051289", "evidence": [ { "database": "UniProtKB", "id": "A0A140T896", "url": "https://www.uniprot.org/uniprot/A0A140T896" } ], "pmid": "" }, { "name": "folic acid metabolic process", "id": "GO:0046655", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046655", "evidence": [ { "database": "UniProtKB", "id": "A0A140T896", "url": "https://www.uniprot.org/uniprot/A0A140T896" } ], "pmid": "" }, { "name": "cellular response to tetrahydrofolate", "id": "GO:1904482", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904482", "evidence": [ { "database": "UniProtKB", "id": "A0A140T896", "url": "https://www.uniprot.org/uniprot/A0A140T896" } ], "pmid": "" }, { "name": "purine nucleobase biosynthetic process", "id": "GO:0009113", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009113", "evidence": [ { "database": "UniProtKB", "id": "A0A140T896", "url": "https://www.uniprot.org/uniprot/A0A140T896" } ], "pmid": "" }, { "name": "tetrahydrofolate metabolic process", "id": "GO:0046653", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046653", "evidence": [ { "database": "UniProtKB", "id": "A0A140T896", "url": "https://www.uniprot.org/uniprot/A0A140T896" } ], "pmid": "" }, { "name": "L-serine catabolic process", "id": "GO:0006565", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006565", "evidence": [ { "database": "UniProtKB", "id": "A0A140T896", "url": "https://www.uniprot.org/uniprot/A0A140T896" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A140T896", "url": "https://www.uniprot.org/uniprot/A0A140T896" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0A140T896", "url": "https://www.uniprot.org/uniprot/A0A140T896" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A140T896", "url": "https://www.uniprot.org/uniprot/A0A140T896" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0A140T896", "url": "https://www.uniprot.org/uniprot/A0A140T896" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0A140T896", "url": "https://www.uniprot.org/uniprot/A0A140T896" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "15481", "name": "", "equation": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A140T896-1", "Q3SZ20-1", "Q5E9P9-1", "A0AAA9TQ60-1" ], "evidence": [ { "id": "15481", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/15481" } ] }, { "id": "R-BTA-200651", "name": "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A140T896-1" ], "evidence": [ { "id": "R-BTA-200651", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-200651" } ] }, { "id": "R-BTA-200735", "name": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A140T896-1" ], "evidence": [ { "id": "R-BTA-200735", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-200735" } ] }, { "id": "R-BTA-71249", "name": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. 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