{ "uniprot_canonical_ac": "A0A0G2K8F9-1", "uniprot_ac": "A0A0G2K8F9", "uniprot_id": "A0A0G2K8F9_RAT", "mass": { "chemical_mass": 114360.0, "monoisotopic_mass": 114360.0 }, "refseq": { "ac": "XP_006239941", "name": "pumilio homolog 2 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006239941" }, "gene_names": [ { "name": "Pum2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A0G2K8F9", "id": "A0A0G2K8F9" }, { "name": "Pum2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006239941", "id": "XP_006239941" } ], "protein_names": [ { "name": "Pumilio RNA-binding family member 2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K8F9/entry#names_and_taxonomy", "id": "A0A0G2K8F9" }, { "name": "pumilio homolog 2 isoform X1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006239941", "id": "XP_006239941" } ], "function": [], "disease": [ { "disease_id": "DOID:9970", "recommended_name": { "id": "DOID:9970", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9970", "name": "obesity", "description": "An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness." }, "synonyms": [ { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "inherited obesity", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "genetic obesity", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "genetic obesity (disease)", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "leanness, inherited, autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "monogenic obesity", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, association with, Autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, early-onset, susceptibility to, Autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, late-onset, Autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, mild, early-onset, Autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, severe, Autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, severe, and type II diabetes, Autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, susceptibility to, Autosomal recessive", "description": "" }, { "id": "MIM:601665", "resource": "MIM", "url": "https://www.omim.org/entry/601665", "name": "Obesity", "description": "Obesity" } ], "evidence": [ { "id": "9970", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:9970" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K8F9", "url": "https://www.uniprot.org/uniprot/A0A0G2K8F9" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "gene": [ { "name": "Pum2", "url": "https://www.uniprot.org/uniprot/A0A0G2K8F9", "locus": { "chromosome": "6", "start_pos": 31542976, "end_pos": 31462872, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000006180", "url": "https://www.ensembl.org/id/ENSRNOG00000006180" } ] } } ], "crossref": [ { "id": "A0A0G2K8F9", "url": "https://alphafold.ebi.ac.uk/entry/A0A0G2K8F9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSRNOG00000006180", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000006180", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07920", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07920", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "298874", "url": "https://www.ncbi.nlm.nih.gov/gene/298874", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001313", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001313", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011989", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033133", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033133", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033712", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033712", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:298874", "url": "https://www.genome.jp/dbget-bin/www_bget?rno:298874", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "XPAVVPP", "url": "https://omabrowser.org/oma/group/XPAVVPP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A0G2K8F9", "url": "https://www.orthodb.org/?gene=A0A0G2K8F9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "D3ZQL8", "url": "https://www.orthodb.org/?gene=D3ZQL8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12537", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12537", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12537:SF52", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12537:SF52", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00806", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00806", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "XP_006239941", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006239941", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "1311024", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1311024", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "A0A0G2K8F9", "url": "https://www.uniprot.org/uniprot/A0A0G2K8F9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2K8F9-1", "url": "https://www.uniprot.org/uniprot/A0A0G2K8F9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5ZSK1", "url": "https://www.uniprot.org/uniprot/A0A8I5ZSK1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5ZSK1-1", "url": "https://www.uniprot.org/uniprot/A0A8I5ZSK1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6AD36", "url": "https://www.uniprot.org/uniprot/A0A8I6AD36", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6AD36-1", "url": "https://www.uniprot.org/uniprot/A0A8I6AD36-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3ZQL8", "url": "https://www.uniprot.org/uniprot/D3ZQL8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3ZQL8-1", "url": "https://www.uniprot.org/uniprot/D3ZQL8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNHDFQALALESRGMGELLPTKKFWEPDDSTKDGQKGIFLGDDEWRETAWGTSHHSMSQPIMVQRRSGQSFHGNSEVNAILSPRSESGGLGVSMVEYVLSSSPADKLDSRFRKGTFGTRDAETDGPEKGDQKGKASPFEEDQNRDLKQDDEDSKINGRGLPNGMDADCKDFNRTPGSRQASPTEVVERLGPSTNPPEGLGPLPNPTANKPLVEEFSNPETQNLDAMDQVGLDSLQFDYPGNQVPMDSSGATVGLFDYNSQQQLFQRTNALTVQQLTAAQQQQYALAAAQQPHIAGVFSAGLAPAAFVPNPYIISAAPPGTDPYTAAGLAAAATLAGPAVVPPQYYGVPWGVYPANLFQQQAAAAASNTANQQAASQAQPGQQQVLRPGAGQRPITPSQGQQGQQAESLAAAAAANPTLAFGQSLAAGMPGYQVLAPTAYYDQTGALVVGPGARTGLGAPVRLMAPTPVLISSAAAQAAAAAAAAGGTANSLTGSTNGLFRPIGTQPPQQQQQQQPSTNLQSNSFYGSSSLTNSSQSSSLFSHGPGQPGSASLGFGSGSSLGAAIGSALSGFGSSVGSSASSSATRRESLSTSSDLYKRSSSSLAPIGQPFYNSLGFSSSPSPIGMPLPSQTPGHSLTPPPSLSSHGSSSSLHLGGLTNGSGRYISAAPGAEAKYRSASSTSSLFSSSSQLFPPSRLRYNRSDIMPSGRSRLLEDFRNNRFPNLQLRDLMGHIVEFSQDQHGSRFIQQKLERATPAERQMVFNEIVQAAYQLMTDVFGNYVIQKFFEFGSLDQKLALANRIRGHVLPLALQMYGCRVIQKALESISSDQQVISEMVKELDGHVLKCVKDQNGNHVVQKCIECVQPQSLQFIIDAFKGQVFVLSTHPYGCRVIQRILEHCTAEQTLPILEELHQHTEQLVQDQYGNYVIQHVLEHGRPEDKSKIVSEIRGKVLALSQHKFASNVVEKCVTHASRAERALLIDEVCCQNDGPHSALYTMMKDQYANYVVQKMIDMAEPAQRKIIMHKIRPHITTLRKYTYGKHILAKLEKYYLKNSPDLGPIGGPPNGML", "length": 1067, "header": "tr|A0A0G2K8F9-1|A0A0G2K8F9_RAT Isoform 1 of Pumilio RNA-binding family member 2 OS=Rattus norvegicus OX=10116 GN=Pum2 PE=1 SV=2 CANONICAL=A0A0G2K8F9-1" }, "isoforms": [ { "isoform_ac": "A0A0G2K8F9-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K8F9/entry#A0A0G2K8F9-1", "sequence": { "sequence": "MNHDFQALALESRGMGELLPTKKFWEPDDSTKDGQKGIFLGDDEWRETAWGTSHHSMSQPIMVQRRSGQSFHGNSEVNAILSPRSESGGLGVSMVEYVLSSSPADKLDSRFRKGTFGTRDAETDGPEKGDQKGKASPFEEDQNRDLKQDDEDSKINGRGLPNGMDADCKDFNRTPGSRQASPTEVVERLGPSTNPPEGLGPLPNPTANKPLVEEFSNPETQNLDAMDQVGLDSLQFDYPGNQVPMDSSGATVGLFDYNSQQQLFQRTNALTVQQLTAAQQQQYALAAAQQPHIAGVFSAGLAPAAFVPNPYIISAAPPGTDPYTAAGLAAAATLAGPAVVPPQYYGVPWGVYPANLFQQQAAAAASNTANQQAASQAQPGQQQVLRPGAGQRPITPSQGQQGQQAESLAAAAAANPTLAFGQSLAAGMPGYQVLAPTAYYDQTGALVVGPGARTGLGAPVRLMAPTPVLISSAAAQAAAAAAAAGGTANSLTGSTNGLFRPIGTQPPQQQQQQQPSTNLQSNSFYGSSSLTNSSQSSSLFSHGPGQPGSASLGFGSGSSLGAAIGSALSGFGSSVGSSASSSATRRESLSTSSDLYKRSSSSLAPIGQPFYNSLGFSSSPSPIGMPLPSQTPGHSLTPPPSLSSHGSSSSLHLGGLTNGSGRYISAAPGAEAKYRSASSTSSLFSSSSQLFPPSRLRYNRSDIMPSGRSRLLEDFRNNRFPNLQLRDLMGHIVEFSQDQHGSRFIQQKLERATPAERQMVFNEIVQAAYQLMTDVFGNYVIQKFFEFGSLDQKLALANRIRGHVLPLALQMYGCRVIQKALESISSDQQVISEMVKELDGHVLKCVKDQNGNHVVQKCIECVQPQSLQFIIDAFKGQVFVLSTHPYGCRVIQRILEHCTAEQTLPILEELHQHTEQLVQDQYGNYVIQHVLEHGRPEDKSKIVSEIRGKVLALSQHKFASNVVEKCVTHASRAERALLIDEVCCQNDGPHSALYTMMKDQYANYVVQKMIDMAEPAQRKIIMHKIRPHITTLRKYTYGKHILAKLEKYYLKNSPDLGPIGGPPNGML", "length": 1067, "header": "tr|A0A0G2K8F9-1|A0A0G2K8F9_RAT Isoform 1 of Pumilio RNA-binding family member 2 OS=Rattus norvegicus OX=10116 GN=Pum2 PE=1 SV=2 CANONICAL=A0A0G2K8F9-1" }, "locus": { "chromosome": "6", "start_pos": 31540141, "end_pos": 31485327, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000082598.2", "url": "https://www.ensembl.org/id/ENSRNOT00000082598.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000074592.2", "url": "https://www.ensembl.org/id/ENSRNOP00000074592.2" } ] } }, { "isoform_ac": "A0A8I5ZSK1-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K8F9/entry#A0A8I5ZSK1-1", "sequence": { "sequence": "MNHDFQALALESRGMGELLPTKKFWEPDDSTKDGQKGIFLGDDEWRETAWGTSHHSMSQPIMVQRRSGQSFHGNSEVNAILSPRSESGGLGVSMVEYVLSSSPADKLDSRFRKGTFGTRDAETDGPEKGDQKGKASPFEEDQNRDLKQDDEDSKINGRGLPNGMDADCKDFNRTPGSRQASPTEVVERLGPSTNPPEGLGPLPNPTANKPLVEEFSNPETQNLDAMDQVGLDSLQFDYPGNQVPMDSSGATVGLFDYNSQQQLFQRTNALTVQQLTAAQQQQYALAAAQQPHIAGVFSAGLAPAAFVPNPYIISAAPPGTDPYTAAGLAAAATLAGPAVVPPQYYGVPWGVYPANLFQQQAAAAASNTANQQAASQAQPGQQQVLRPGAGQRPITPSQGQQGQQAESLAAAAAANPTLAFGQSLAAGMPGYQVLAPTAYYDQTGALVVGPGARTGLGAPVRLMAPTPVLISSAAAQAAAAAAAAGGTANSLTGSTNGLFRPIGTQPPQQQQQQQPSTNLQSNSFYGSSSLTNSSQSSSLFSHGPGQPGSASLGFGSGSSLGAAIGSALSGFGSSGGLTNGSGRYISAAPGAEAKYRSASSTSSLFSSSSQLFPPSRLRYNRSDIMPSGRSRLLEDFRNNRFPNLQLRDLMGHIVEFSQDQHGSRFIQQKLERATPAERQMVFNEIVQAAYQLMTDVFGNYVIQKFFEFGSLDQKLALANRIRGHVLPLALQMYGCRVIQKALESISSDQQSEMVKELDGHVLKCVKDQNGNHVVQKCIECVQPQSLQFIIDAFKGQVFVLSTHPYGCRVIQRILEHCTAEQTLPILEELHQHTEQLVQDQYGNYVIQHVLEHGRPEDKSKIVSEIRGKVLALSQHKFASNVVEKCVTHASRAERALLIDEVCCQNDGPHSALYTMMKDQYANYVVQKMIDMAEPAQRKIIMHKIRPHITTLRKYTYGKHILAKLEKYYLKNSPDLGPIGGPPNGML", "length": 986, "header": "tr|A0A8I5ZSK1-1|A0A0G2K8F9_RAT Computationally mapped isoform of Pumilio RNA-binding family member 2 OS=Rattus norvegicus OX=10116 GN=Pum2 PE=1 SV=1 CANONICAL=A0A0G2K8F9-1" }, "locus": { "chromosome": "6", "start_pos": 31540141, "end_pos": 31485327, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000108134.1", "url": "https://www.ensembl.org/id/ENSRNOT00000108134.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000081323.1", "url": "https://www.ensembl.org/id/ENSRNOP00000081323.1" } ] } }, { "isoform_ac": "A0A8I6AD36-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K8F9/entry#A0A8I6AD36-1", "sequence": { "sequence": "ENKSFKQIKISFEYGQKGIFLGDDEWRETAWGTSHHSMSQPIMVQRRSGQSFHGNSEVNAILSPRSESGGLGVSMVEYVLSSSPADKLDSRFRKGTFGTRDAETDGPEKGDQKGKASPFEEDQNRDLKQDDEDSKINGRGLPNGMDADCKDFNRTPGSRQASPTEVVERLGPSTNPPEGLGPLPNPTANKPLVEEFSNPETQNLDAMDQVGLDSLQFDYPGNQVPMDSSGATVGLFDYNSQQQLFQRTNALTVQQLTAAQQQQYALAAAQQPHIAGVFSAGLAPAAFVPNPYIISAAPPGTDPYTAAGLAAAATLAGPAVVPPQYYGVPWGVYPANLFQQQAAAAASNTANQQAASQAQPGQQQVLRPGAGQRPITPSQGQQGQQAESLAAAAAANPTLAFGQSLAAGMPGYQVLAPTAYYDQTGALVVGPGARTGLGAPVRLMAPTPVLISSAAAQAAAAAAAAGGTANSLTGSTNGLFRPIGTQPPQQQQQQQPSTNLQSNSFYGSSSLTNSSQSSSLFSHGPGQPGSASLGFGSGSSLGAAIGSALSGFGSSVGSSASSSATRRESLSTSSDLYKRSSSSLAPIGQPFYNSLGFSSSPSPIGMPLPSQTPGHSLTPPPSLSSHGSSSRGLTNGSGRYISAAPGAEAKYRSASSTSSLFSSSSQLFPPSRLRYNRSDIMPSGRSRLLEDFRNNRFPNLQLRDLMGHIVEFSQDQHGSRFIQQKLERATPAERQMVFNEIVQAAYQLMTDVFGNYVIQKFFEFGSLDQKLALANRIRGHVLPLALQMYGCRVIQKALESISSDQQSEMVKELDGHVLKCVKDQNGNHVVQKCIECVQPQSLQFIIDAFKGQVFVLSTHPYGCRVIQRILEHCTAEQTLPILEELHQHTEQLVQDQYGNYVIQHVLEHGRPEDKSKIVSEIRGKVLALSQHKFASNVVEKCVTHASRAERALLIDEVCCQNDGPHSALYTMMKDQYANYVVQKMIDMAEPAQRKIIMHKIRPHITTLRKYTYGKHILAKLEKYYLKNSPDLGPIGGPPNGML", "length": 1042, "header": "tr|A0A8I6AD36-1|A0A8I6AD36_RAT Computationally mapped isoform of Pumilio RNA-binding family member 2 OS=Rattus norvegicus OX=10116 GN=Pum2 PE=1 SV=1 CANONICAL=A0A0G2K8F9-1" }, "locus": { "chromosome": "6", "start_pos": 31540141, "end_pos": 31492016, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000095958.1", "url": "https://www.ensembl.org/id/ENSRNOT00000095958.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000089681.1", "url": "https://www.ensembl.org/id/ENSRNOP00000089681.1" } ] } }, { "isoform_ac": "D3ZQL8-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K8F9/entry#D3ZQL8-1", "sequence": { "sequence": "MNHDFQALALESRGMGELLPTKKFWEPDDSTKDGQKGIFLGDDEWRETAWGTSHHSMSQPIMVQRRSGQSFHGNSEVNAILSPRSESGGLGVSMVEYVLSSSPADKLDSRFRKGTFGTRDAETDGPEKGDQKGKASPFEEDQNRDLKQDDEDSKINGRGLPNGMDADCKDFNRTPGSRQASPTEVVERLGPSTNPPEGLGPLPNPTANKPLVEEFSNPETQNLDAMDQVGLDSLQFDYPGNQVPMDSSGATVGLFDYNSQQQLFQRTNALTVQQLTAAQQQQYALAAAQQPHIAGVFSAGLAPAAFVPNPYIISAAPPGTDPYTAAGLAAAATLAGPAVVPPQYYGVPWGVYPANLFQQQAAAAASNTANQQAASQAQPGQQQVLRPGAGQRPITPSQGQQGQQAESLAAAAAANPTLAFGQSLAAGMPGYQVLAPTAYYDQTGALVVGPGARTGLGAPVRLMAPTPVLISSAAAQAAAAAAAAGGTANSLTGSTNGLFRPIGTQPPQQQQQQQPSTNLQSNSFYGSSSLTNSSQSSSLFSHGPGQPGSASLGFGSGSSLGAAIGSALSGFGSSVGSSASSSATRRESLSTSSDLYKRSSSSLAPIGQPFYNSLGFSSSPSPIGMPLPSQTPGHSLTPPPSLSSHGSSSRGLTNGSGRYISAAPGAEAKYRSASSTSSLFSSSSQLFPPSRLRYNRSDIMPSGRSRLLEDFRNNRFPNLQLRDLMGHIVEFSQDQHGSRFIQQKLERATPAERQMVFNEIVQAAYQLMTDVFGNYVIQKFFEFGSLDQKLALANRIRGHVLPLALQMYGCRVIQKALESISSDQQSEMVKELDGHVLKCVKDQNGNHVVQKCIECVQPQSLQFIIDAFKGQVFVLSTHPYGCRVIQRILEHCTAEQTLPILEELHQHTEQLVQDQYGNYVIQHVLEHGRPEDKSKIVSEIRGKVLALSQHKFASNVVEKCVTHASRAERALLIDEVCCQNDGPHSALYTMMKDQYANYVVQKMIDMAEPAQRKIIMHKIRPHITTLRKYTYGKHILAKLEKYYLKNSPDLGPIGGPPNGML", "length": 1061, "header": "tr|D3ZQL8-1|D3ZQL8_RAT Computationally mapped isoform of Pumilio RNA-binding family member 2 OS=Rattus norvegicus OX=10116 GN=Pum2 PE=1 SV=2 CANONICAL=A0A0G2K8F9-1" }, "locus": { "chromosome": "6", "start_pos": 31540141, "end_pos": 31485327, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000008359.7", "url": "https://www.ensembl.org/id/ENSRNOT00000008359.7" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000008359.5", "url": "https://www.ensembl.org/id/ENSRNOP00000008359.5" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 136, "end_pos": 136, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "D3ZQL8", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/D3ZQL8" } ], "site_lbl": "Ser136" }, { "start_pos": 181, "end_pos": 181, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "D3ZQL8", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/D3ZQL8" } ], "site_lbl": "Ser181" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "journal": "Nat. Commun.", "date": "2012", "authors": "Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K8F9", "url": "https://www.uniprot.org/uniprot/A0A0G2K8F9" } ], "reference": [ { "type": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" } ] } ], "pathway": [ { "id": "rno:298874", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?rno:298874", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0XR72-1", "protein_name": "Pumilio RNA binding family member 2", "gene_name": "PUM2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": 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"length": 1066 }, "evidence": [ { "id": "47568408", "url": "http://www.informatics.jax.org/homology/47568408", "database": "MGI" }, { "id": "A0A0G2K8F9", "url": "https://omabrowser.org/oma/group/A0A0G2K8F9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8TB72-1", "protein_name": "Pumilio homolog 2", "gene_name": "PUM2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNHDFQALALESRGMGELLPTKKFWEPDDSTKDGQKGIFLGDDEWRETAWGASHHSMSQPIMVQRRSGQGFHGNSEVNAILSPRSESGGLGVSMVEYVLSSSPADKLDSRFRKGNFGTRDAETDGPEKGDQKGKASPFEEDQNRDLKQGDDDDSKINGRGLPNGMDADCKDFNRTPGSRQASPTEVVERLGPNTNPSEGLGPLPNPTANKPLVEEFSNPETQNLDAMEQVGLESLQFDYPGNQVPMDSSGATVGLFDYNSQQQLFQRTNALTVQQLTAAQQQQYALAAAQQPHIAGVFSAGLAPAAFVPNPYIISAAPPGTDPYTAAGLAAAATLAGPAVVPPQYYGVPWGVYPANLFQQQAAAAANNTASQQAASQAQPGQQQVLRAGAGQRPLTPNQGQQGQQAESLAAAAAANPTLAFGQGLATGMPGYQVLAPTAYYDQTGALVVGPGARTGLGAPVRLMAPTPVLISSAAAQAAAAAAAGGTASSLTGSTNGLFRPIGTQPPQQQQQQPSTNLQSNSFYGSSSLTNSSQSSSLFSHGPGQPGSTSLGFGSGNSLGAAIGSALSGFGSSVGSSASSSATRRESLSTSSDLYKRSSSSLAPIGQPFYNSLGFSSSPSPIGMPLPSQTPGHSLTPPPSLSSHGSSSSLHLGGLTNGSGRYISAAPGAEAKYRSASSTSSLFSSSSQLFPPSRLRYNRSDIMPSGRSRLLEDFRNNRFPNLQLRDLIGHIVEFSQDQHGSRFIQQKLERATPAERQMVFNEILQAAYQLMTDVFGNYVIQKFFEFGSLDQKLALATRIRGHVLPLALQMYGCRVIQKALESISSDQQVISEMVKELDGHVLKCVKDQNGNHVVQKCIECVQPQSLQFIIDAFKGQVFVLSTHPYGCRVIQRILEHCTAEQTLPILEELHQHTEQLVQDQYGNYVIQHVLEHGRPEDKSKIVSEIRGKVLALSQHKFASNVVEKCVTHASRAERALLIDEVCCQNDGPHSALYTMMKDQYANYVVQKMIDMAEPAQRKIIMHKIRPHITTLRKYTYGKHILAKLEKYYLKNSPDLGPIGGPPNGML", 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"A0A0G2K8F9", "url": "https://www.uniprot.org/uniprot/A0A0G2K8F9" } ], "pmid": "" }, { "name": "neuronal cell body", "id": "GO:0043025", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043025", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K8F9", "url": "https://www.uniprot.org/uniprot/A0A0G2K8F9" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K8F9", "url": "https://www.uniprot.org/uniprot/A0A0G2K8F9" } ], "pmid": "" }, { "name": "postsynapse", "id": "GO:0098794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098794", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K8F9", "url": "https://www.uniprot.org/uniprot/A0A0G2K8F9" } ], "pmid": "" }, { "name": "cytoplasmic stress granule", "id": "GO:0010494", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010494", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K8F9", "url": "https://www.uniprot.org/uniprot/A0A0G2K8F9" } ], "pmid": "" }, { "name": "nuclear membrane", "id": "GO:0031965", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031965", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K8F9", "url": "https://www.uniprot.org/uniprot/A0A0G2K8F9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K8F9", "url": "https://www.uniprot.org/uniprot/A0A0G2K8F9" } ], "pmid": "" }, { "name": "miRNA binding", "id": "GO:0035198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035198", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K8F9", "url": "https://www.uniprot.org/uniprot/A0A0G2K8F9" } ], "pmid": "" }, { "name": "mRNA 3'-UTR binding", "id": "GO:0003730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003730", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K8F9", "url": "https://www.uniprot.org/uniprot/A0A0G2K8F9" } ], "pmid": "" }, { "name": "lncRNA binding", "id": "GO:0106222", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0106222", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K8F9", "url": "https://www.uniprot.org/uniprot/A0A0G2K8F9" } ], "pmid": "" }, { "name": "pumilio-response element binding", "id": "GO:0062104", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0062104", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K8F9", "url": "https://www.uniprot.org/uniprot/A0A0G2K8F9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 18, "go_terms": [ { "name": "regulation of translation", "id": "GO:0006417", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006417", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K8F9", "url": "https://www.uniprot.org/uniprot/A0A0G2K8F9" } ], "pmid": "" }, { "name": "negative regulation of gene expression", "id": "GO:0010629", "url": 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of chromosome segregation", "id": "GO:0051983", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051983", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K8F9", "url": "https://www.uniprot.org/uniprot/A0A0G2K8F9" } ], "pmid": "" }, { "name": "chromosome organization", "id": "GO:0051276", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051276", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K8F9", "url": "https://www.uniprot.org/uniprot/A0A0G2K8F9" } ], "pmid": "" }, { "name": "regulation of intracellular mRNA localization", "id": "GO:1904580", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904580", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K8F9", "url": "https://www.uniprot.org/uniprot/A0A0G2K8F9" } ], "pmid": "" }, { "name": "regulation of postsynapse assembly", "id": "GO:0150052", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0150052", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K8F9", "url": "https://www.uniprot.org/uniprot/A0A0G2K8F9" } ], "pmid": "" 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