The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [ "R-ALL-1629741" ], "enzyme_list": [ "A0A0G2K7L4-1" ], "evidence": [ { "id": "R-RNO-1855159", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1855159" } ] }, { "id": "R-RNO-1855162", "name": "I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [ "R-ALL-994141" ], "enzyme_list": [ "A0A0G2K7L4-1" ], "evidence": [ { "id": "R-RNO-1855162", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1855162" } ] }, { "id": "R-RNO-1855169", "name": "I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [ "R-ALL-994146" ], "enzyme_list": [ "A0A0G2K7L4-1" ], "evidence": [ { "id": "R-RNO-1855169", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1855169" } ] }, { "id": "R-RNO-1855171", "name": "I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [ "R-ALL-994123" ], "enzyme_list": [ "A0A0G2K7L4-1" ], "evidence": [ { "id": "R-RNO-1855171", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1855171" } ] }, { "id": "R-RNO-1855172", "name": "I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A0G2K7L4-1" ], "evidence": [ { "id": "R-RNO-1855172", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1855172" } ] }, { "id": "R-RNO-1855197", "name": "I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A0G2K7L4-1" ], "evidence": [ { "id": "R-RNO-1855197", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1855197" } ] }, { "id": "R-RNO-1855218", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "D3ZGS3-1", "P97573-1", "Q9JMC1-1", "Q62910-1", "Q9WVR3-1", "A0A0G2K7L4-1" ], "evidence": [ { "id": "R-RNO-1855218", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1855218" } ] }, { "id": "R-RNO-1855219", "name": "I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [ "R-ALL-994149" ], "enzyme_list": [ "A0A0G2K7L4-1" ], "evidence": [ { "id": "R-RNO-1855219", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1855219" } ] }, { "id": "R-RNO-2267372", "name": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A0G2K7L4-1" ], "evidence": [ { "id": "R-RNO-2267372", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2267372" } ] }, { "id": "R-RNO-994137", "name": "ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A0G2K7L4-1" ], "evidence": [ { "id": "R-RNO-994137", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-994137" } ] }, { "id": "R-RNO-994140", "name": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A0G2K7L4-1" ], "evidence": [ { "id": "R-RNO-994140", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-994140" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-1629741", "participant_name": "I(3,4,6)P3 [cytosol]", "crossref": [ { "id": "62918", "database": "ChEBI", "url": "" }, { "id": "000033902518", "database": "ZINC", "url": "" } ] }, { "participant_id": "R-ALL-994123", "participant_name": "I(1,3,4)P3 [cytosol]", "crossref": [ { "id": "58414", "database": "ChEBI", "url": "" }, { "id": "HMDB0304318", "database": "HMDB Metabolite", "url": "" }, { "id": "000004095596", "database": "ZINC", "url": "" } ] }, { "participant_id": "R-ALL-994141", "participant_name": "I(1,3,4,5,6)P5 [cytosol]", "crossref": [ { "id": "57733", "database": "ChEBI", "url": "" }, { "id": "000100015963", "database": "ZINC", "url": "" } ] }, { "participant_id": "R-ALL-994146", "participant_name": "I(1,3,4,6)P4 [cytosol]", "crossref": [ { "id": "57660", "database": "ChEBI", "url": "" }, { "id": "000071789370", "database": "ZINC", "url": "" } ] }, { "participant_id": "R-ALL-994149", "participant_name": "I(3,4,5,6)P4 [cytosol]", "crossref": [ { "id": "57539", "database": "ChEBI", "url": "" }, { "id": "000004096446", "database": "ZINC", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A0G2K7L4", "gene_name": "Itpk1", "activity": [ { "ec_number": "2.7.1.134", "activity": "1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+).", "evidence": [ { "id": "A0A0G2K7L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K7L4" } ] }, { "ec_number": "2.7.1.159", "activity": "1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+).", "evidence": [ { "id": "A0A0G2K7L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K7L4" } ] }, { "ec_number": "2.7.1.134", "activity": "", "evidence": [ { "id": "A0A0G2K7L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K7L4" } ] }, { "ec_number": "2.7.1.159", "activity": "", "evidence": [ { "id": "A0A0G2K7L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K7L4" } ] } ] }, { "uniprot_ac": "D3ZGS3", "gene_name": "Ocrl", "activity": [ { "ec_number": "3.1.3.36", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.", "evidence": [ { "id": "D3ZGS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZGS3" } ] }, { "ec_number": "3.1.3.36", "activity": "", "evidence": [ { "id": "D3ZGS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZGS3" } ] }, { "ec_number": "3.1.3.86", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate.", "evidence": [ { "id": "D3ZGS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZGS3" } ] }, { "ec_number": "3.1.3.56", "activity": "1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate.", "evidence": [ { "id": "D3ZGS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZGS3" } ] }, { "ec_number": "3.1.3.56", "activity": "", "evidence": [ { "id": "D3ZGS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZGS3" } ] } ] }, { "uniprot_ac": "P97573", "gene_name": "Inpp5d", "activity": [ { "ec_number": "3.1.3.86", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate.", "evidence": [ { "id": "P97573", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97573" } ] }, { "ec_number": "3.1.3.56", "activity": "1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate.", "evidence": [ { "id": "P97573", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97573" } ] }, { "ec_number": "3.1.3.36", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.", "evidence": [ { "id": "P97573", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97573" } ] }, { "ec_number": "3.1.3.86", "activity": "", "evidence": [ { "id": "P97573", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97573" } ] } ] }, { "uniprot_ac": "Q62910", "gene_name": "Synj1", "activity": [ { "ec_number": "3.1.3.36", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.", "evidence": [ { "id": "Q62910", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62910" } ] }, { "ec_number": "3.1.3.36", "activity": "", "evidence": [ { "id": "Q62910", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62910" } ] } ] }, { "uniprot_ac": "Q9JMC1", "gene_name": "Inpp5j", "activity": [ { "ec_number": "3.1.3.56", "activity": "1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate.", "evidence": [ { "id": "Q9JMC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JMC1" } ] }, { "ec_number": "3.1.3.36", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.", "evidence": [ { "id": "Q9JMC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JMC1" } ] }, { "ec_number": "3.1.3.36", "activity": "", "evidence": [ { "id": "Q9JMC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JMC1" } ] } ] }, { "uniprot_ac": "Q9WVR3", "gene_name": "Inppl1", "activity": [ { "ec_number": "3.1.3.86", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate.", "evidence": [ { "id": "Q9WVR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WVR3" } ] }, { "ec_number": "3.1.3.86", "activity": "", "evidence": [ { "id": "Q9WVR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WVR3" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A0G2K7L4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 463, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A0G2K7L4-F1.pdb" } ], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.7.1.134", "ec_name": "1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+).", "evidence": [ { "id": "2.7.1.134", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.134" }, { "id": "2.7.1.134", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.1.134" } ] }, { "ec_number": "2.7.1.159", "ec_name": "1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+).", "evidence": [ { "id": "2.7.1.159", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.159" }, { "id": "2.7.1.159", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.1.159" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 217, "end_pos": 219 }, { "start_pos": 276, "end_pos": 278 }, { "start_pos": 328, "end_pos": 330 }, { "start_pos": 42, "end_pos": 44 }, { "start_pos": 70, "end_pos": 72 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }