{ "uniprot_canonical_ac": "A0A0G2K7F0-1", "uniprot_ac": "A0A0G2K7F0", "uniprot_id": "A0A0G2K7F0_RAT", "mass": { "chemical_mass": 225106.0, "monoisotopic_mass": 225106.0 }, "refseq": {}, "gene_names": [ { "name": "Fancm", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A0G2K7F0", "id": "A0A0G2K7F0" } ], "protein_names": [ { "name": "FA complementation group M", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K7F0/entry#names_and_taxonomy", "id": "A0A0G2K7F0" } ], "function": [], "disease": [ { "disease_id": "DOID:0050865", "recommended_name": { "id": "DOID:0050865", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050865", "name": "tongue squamous cell carcinoma", "description": "A head and neck squamous cell carcinoma that is located_in the tongue." }, "synonyms": [], "evidence": [ { "id": "0050865", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0050865" } ] }, { "disease_id": "DOID:0080872", "recommended_name": { "id": "DOID:0080872", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080872", "name": "primary ovarian insufficiency 15", "description": "A primary ovarian insufficiency that is characterized by onset of oligomenorrhea in the third decade of life, with small ovaries, reduced number of follicles, and elevated gonadotropic hormones and that has_material_basis_in homozygous mutation in the FANCM gene on chromosome 14q21." }, "synonyms": [ { "id": "MONDO:0054862", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0054862", "name": "premature ovarian failure 15", "description": "" }, { "id": "MONDO:0054862", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0054862", "name": "premature ovarian failure 15", "description": "" }, { "id": "MONDO:0054862", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0054862", "name": "POF15", "description": "" }, { "id": "MIM:618096", "resource": "MIM", "url": "https://www.omim.org/entry/618096", "name": "Premature ovarian failure 15", "description": "Premature ovarian failure 15" } ], "evidence": [ { "id": "0080872", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0080872" } ] }, { "disease_id": "DOID:0111916", "recommended_name": { "id": "DOID:0111916", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111916", "name": "spermatogenic failure 28", "description": "A spermatogenic failure characterized by nonobstructive azoospermia and a Sertoli cell-only phenotype in testes that has_material_basis_in homozygous or compound heterozygous mutation in the FANCM gene on chromosome 14q21.2." }, "synonyms": [ { "id": "DOID:0111916", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111916", "name": "SPGF28", "description": "" }, { "id": "MONDO:0054732", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0054732", "name": "spermatogenic failure 28", "description": "" }, { "id": "MONDO:0054732", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0054732", "name": "spermatogenic failure 28", "description": "" }, { "id": "MONDO:0054732", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0054732", "name": "SPGF28", "description": "" }, { "id": "MIM:618086", "resource": "MIM", "url": "https://www.omim.org/entry/618086", "name": "Spermatogenic failure 28", "description": "Spermatogenic failure 28" } ], "evidence": [ { "id": "0111916", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0111916" } ] }, { "disease_id": "DOID:13636", "recommended_name": { "id": "DOID:13636", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:13636", "name": "Fanconi anemia", "description": "A congenital hypoplastic anemia characterized by progressive pancytopenia with bone marrow failure, variable congenital malformations and predisposition to develop hematological or solid tumors. It is a result of a genetic defect in a cluster of proteins responsible for DNA repair." }, "synonyms": [ { "id": "DOID:13636", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:13636", "name": "Fanconi anaemia", "description": "" }, { "id": "DOID:13636", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:13636", "name": "Fanconi pancytopenia", "description": "" }, { "id": "DOID:13636", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:13636", "name": "Fanconi panmyelopathy", "description": "" }, { "id": "DOID:13636", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:13636", "name": "Fanconi's anaemia", "description": "" }, { "id": "DOID:13636", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:13636", "name": "Fanconi's anemia", "description": "" }, { "id": "MONDO:0009215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009215", "name": "Fanconi anemia complementation group A", "description": "Fanconi anemia caused by mutations of the FANCA gene. FANCA gene mutations are the most common cause of Fanconi anemia. This gene provides instructions for making a protein that is involved in the Fanconi anemia (FA) pathway." }, { "id": "MONDO:0009215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009215", "name": "FANCA", "description": "" }, { "id": "MONDO:0009215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009215", "name": "FANCA Fanconi anaemia", "description": "" }, { "id": "MONDO:0009215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009215", "name": "FANCA Fanconi anemia", "description": "" }, { "id": "MONDO:0009215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009215", "name": "Fanconi Anemia, complementation group type a", "description": "" }, { "id": "MONDO:0009215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009215", "name": "Fanconi anaemia caused by mutation in FANCA", "description": "" }, { "id": "MONDO:0009215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009215", "name": "Fanconi anaemia complementation group type A", "description": "" }, { "id": "MONDO:0009215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009215", "name": "Fanconi anemia caused by mutation in FANCA", "description": "" }, { "id": "MONDO:0009215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009215", "name": "Fanconi anemia complementation group A", "description": "" }, { "id": "MONDO:0009215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009215", "name": "Fanconi anemia complementation group type A", "description": "" }, { "id": "MONDO:0009215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009215", "name": "Estren-Dameshek variant of Fanconi Anaemia", "description": "" }, { "id": "MONDO:0009215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009215", "name": "Estren-Dameshek variant of Fanconi Anemia", "description": "" }, { "id": "MONDO:0009215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009215", "name": "Estren-Dameshek variant of Fanconi pancytopenia", "description": "" }, { "id": "MONDO:0009215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009215", "name": "Fanconi Anaemia", "description": "" }, { "id": "MONDO:0009215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009215", "name": "Fanconi Anemia", "description": "" }, { "id": "MONDO:0009215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009215", "name": "Fanconi Anemia, Estren-Dameshek variant", "description": "" }, { "id": "MONDO:0009215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009215", "name": "Fanconi anemia, complementation group A", "description": "" }, { "id": "MIM:227650", "resource": "MIM", "url": "https://www.omim.org/entry/227650", "name": "Fanconi anemia, complementation group A", "description": "Fanconi anemia, complementation group A" } ], "evidence": [ { "id": "13636", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:13636" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K7F0", "url": "https://www.uniprot.org/uniprot/A0A0G2K7F0" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "gene": [ { "name": "Fancm", "url": "https://www.uniprot.org/uniprot/A0A0G2K7F0", "locus": { "chromosome": "6", "start_pos": 83180028, "end_pos": 83127093, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000056721", "url": "https://www.ensembl.org/id/ENSRNOG00000056721" } ] } } ], "crossref": [ { "id": "A0A0G2K7F0", "url": "https://alphafold.ebi.ac.uk/entry/A0A0G2K7F0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSRNOG00000056721", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000056721", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd12091", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12091", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd18033", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18033", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd18801", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18801", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd20077", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20077", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001650", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001650", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006166", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006166", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010994", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010994", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011335", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011335", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011545", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011545", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014001", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014001", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031879", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031879", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039686", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039686", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044749", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044749", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047418", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047418", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "MQMLPND", "url": "https://omabrowser.org/oma/group/MQMLPND/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR14025", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14025", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14025:SF20", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14025:SF20", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00270", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00270", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00271", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00271", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF02732", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02732", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF16783", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16783", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-6783310", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6783310", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9833482", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "1307897", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1307897", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "A0A0G2K7F0", "url": "https://www.uniprot.org/uniprot/A0A0G2K7F0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2K7F0-1", "url": "https://www.uniprot.org/uniprot/A0A0G2K7F0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1W2Q6G5", "url": "https://www.uniprot.org/uniprot/A0A1W2Q6G5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1W2Q6G5-1", "url": "https://www.uniprot.org/uniprot/A0A1W2Q6G5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSGRQRTLFQTWGPSLVRGAGAPGCGQPRSPAVTESLPEEDDEVLLVAAYEAEQQLDPGDGGFCAAAGALWIYPTNCPVRDYQLDISRTALFCNTLVCLPTGLGKTFIAAVVMYNFYRWFPSGKVVFMAPTKPLVTQQMEACFHVMGIPQSHMAEMTGSTQAVNRKEIWSSRRVLFLTPQVMVNDLTRGAVPAAHVKCLVVDEAHKALGNYAYCQVVRELVKYTNHFRILALSATPGSDIKAVQQVITNLLIEKIELRSEDSPDILPYSHERRVEKLVVPLGEELGAIQKTYVQILETFASSLIKRNILMKRDIPNLTKYQIILARDQFRKNPSPNIVGVQQGIIEGELAICISLYHGYELLQQLGMRSLYFFLSGIMDGTKGMTRVKTELSRNEDFTKLYSHLQSVFAHVRDAAAASEASAFQKGNKEKKFVYSHPKLKKLEEVILEHFKSWNAKNTTEKKCQESRVMIFSSFRDSVEEIAEMLSQHQPGVRVMTFVGHASGKNTKGYTQKEQLRVVRQFRDGGYNTLVSTCVGEEGLDIGEVDLIICFDAQKSPIRLIQRMGRTGRRRQGRIVVILAEGREERTYNQSQSNKKNIYKAISGNRQVLRLYQGSPRMVPDKINPELHKMFITHGVYESEKARSVQRKSFSSRSGIKAGNSNKDGLLSEEEFNLWNRLYRLGDSDTVKGVALPRSHFLSLQEDRVAQEPTTGIHQLSLSEWSLWQDHPLPTHQVEHSDRCHHFISIMRMIEGMRHEEDECSYELKIKPFLQMEDVYSKYNAPRNGYKNVASVTRIAPKKSSFRPSVDAGGSLSVTESEEGCADTVEQMDSEWTKITSLREKATTVGKGQTREQTDDDHDDADSSDSDRNSPADVVSRVPPSGERVADVGGIPILGAVTEDDSHTGTLLMECQVTEKSLARYSLDSGYSSFSDDKSLSSHLFLPLEEELYTERAAELFYRCQPMTEEVLANVEKFLSHSPPSLSGLSDVEYAVTQGFELDNESCLPYPEREHSPKPGSPYPEREHSPKPASLALYTAVNSQSNLELNSAKHTNPPSEKDCLPATTHNNIPDQPSFCDSDSETHNIKNQNLVSNSYGQIQVNLENNLVDENSHDDSEPPVLFTDEDESLLLFEDDLKNIEDGTEELNGVGLPPLDRISQPLCVSDKTLISEMPPVSHFLISDELLDDDSEPEDQIICDTKCWEGVEGRDEEIKTEGQPFDCSADLFSVTFDLGFCSSGSDDENPARASDRSSTLGTAEVPGRHSDKEVKDASHASGPLGGTISPIPSEKMPWSPCAQSKECAPFHSALSLPVRERAMSTPLSKAHRSSKTGAHVLKTLDSTKEKAGGQGFKVTLNPRFDNLGFSVEETKSSDQLSVYQSPRCPKVEHLTSESEDDVFLKKTRKPKGNVLKSPEDQKNNEVDSPIHVVKKSRVLRSELSSSDDESENFHRPCPKLEYFKDRNRNTRKGSKAQKKRIHMKALARGFLDEEAEVSGEDADCVSSDEGDDSENEKDSSLLDFVNDRTQLSQAINDSEMRAIYMKSVRSPLMSTKYKMVREKHNSMNIFSQIPEQDENYLEDSFCVAEEESCRSQSSEEEIFVDFNLTKDSFTDEDIRYKTRHAVKLKQMNKKQNCTRSRKKLSRIILPDSDSSEEENTANGREDPSAGGHAADKHTQQGQLWASGPSGSVQPKVLCNPAGNQSSGQRLQVLPNIMDAVPGALNVRAQSHNQTKSTSPPCASVESRKECGNRPVQLKVGDQDTSAAPCSASLLPDAEVLIAPRHPREGNRACILVDSREITTGLEVISSLRTVHGLQVEICPLNGCDYIVSNRMVVERKSQSEMLSNTAKNKFIEQIQRLQSMFQRICVIVEKDREKAGDISKMFRRTKCYDSLLTALVGAGIRILFSSGQEETAGLIKELSLVEQRKNAGIHIPAVLDTGTCEALQFYLSIPGVSYVTALNMCHQFSSVKKMVNSSPEEISTCAQVTHQKAEEIYKYIHYTFDMQMLPNDLTQERQKSETCSTL", "length": 2017, "header": "tr|A0A0G2K7F0-1|A0A0G2K7F0_RAT Isoform 1 of FA complementation group M OS=Rattus norvegicus OX=10116 GN=Fancm PE=3 SV=1 CANONICAL=A0A0G2K7F0-1" }, "isoforms": [ { "isoform_ac": "A0A0G2K7F0-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K7F0/entry#A0A0G2K7F0-1", "sequence": { "sequence": "MSGRQRTLFQTWGPSLVRGAGAPGCGQPRSPAVTESLPEEDDEVLLVAAYEAEQQLDPGDGGFCAAAGALWIYPTNCPVRDYQLDISRTALFCNTLVCLPTGLGKTFIAAVVMYNFYRWFPSGKVVFMAPTKPLVTQQMEACFHVMGIPQSHMAEMTGSTQAVNRKEIWSSRRVLFLTPQVMVNDLTRGAVPAAHVKCLVVDEAHKALGNYAYCQVVRELVKYTNHFRILALSATPGSDIKAVQQVITNLLIEKIELRSEDSPDILPYSHERRVEKLVVPLGEELGAIQKTYVQILETFASSLIKRNILMKRDIPNLTKYQIILARDQFRKNPSPNIVGVQQGIIEGELAICISLYHGYELLQQLGMRSLYFFLSGIMDGTKGMTRVKTELSRNEDFTKLYSHLQSVFAHVRDAAAASEASAFQKGNKEKKFVYSHPKLKKLEEVILEHFKSWNAKNTTEKKCQESRVMIFSSFRDSVEEIAEMLSQHQPGVRVMTFVGHASGKNTKGYTQKEQLRVVRQFRDGGYNTLVSTCVGEEGLDIGEVDLIICFDAQKSPIRLIQRMGRTGRRRQGRIVVILAEGREERTYNQSQSNKKNIYKAISGNRQVLRLYQGSPRMVPDKINPELHKMFITHGVYESEKARSVQRKSFSSRSGIKAGNSNKDGLLSEEEFNLWNRLYRLGDSDTVKGVALPRSHFLSLQEDRVAQEPTTGIHQLSLSEWSLWQDHPLPTHQVEHSDRCHHFISIMRMIEGMRHEEDECSYELKIKPFLQMEDVYSKYNAPRNGYKNVASVTRIAPKKSSFRPSVDAGGSLSVTESEEGCADTVEQMDSEWTKITSLREKATTVGKGQTREQTDDDHDDADSSDSDRNSPADVVSRVPPSGERVADVGGIPILGAVTEDDSHTGTLLMECQVTEKSLARYSLDSGYSSFSDDKSLSSHLFLPLEEELYTERAAELFYRCQPMTEEVLANVEKFLSHSPPSLSGLSDVEYAVTQGFELDNESCLPYPEREHSPKPGSPYPEREHSPKPASLALYTAVNSQSNLELNSAKHTNPPSEKDCLPATTHNNIPDQPSFCDSDSETHNIKNQNLVSNSYGQIQVNLENNLVDENSHDDSEPPVLFTDEDESLLLFEDDLKNIEDGTEELNGVGLPPLDRISQPLCVSDKTLISEMPPVSHFLISDELLDDDSEPEDQIICDTKCWEGVEGRDEEIKTEGQPFDCSADLFSVTFDLGFCSSGSDDENPARASDRSSTLGTAEVPGRHSDKEVKDASHASGPLGGTISPIPSEKMPWSPCAQSKECAPFHSALSLPVRERAMSTPLSKAHRSSKTGAHVLKTLDSTKEKAGGQGFKVTLNPRFDNLGFSVEETKSSDQLSVYQSPRCPKVEHLTSESEDDVFLKKTRKPKGNVLKSPEDQKNNEVDSPIHVVKKSRVLRSELSSSDDESENFHRPCPKLEYFKDRNRNTRKGSKAQKKRIHMKALARGFLDEEAEVSGEDADCVSSDEGDDSENEKDSSLLDFVNDRTQLSQAINDSEMRAIYMKSVRSPLMSTKYKMVREKHNSMNIFSQIPEQDENYLEDSFCVAEEESCRSQSSEEEIFVDFNLTKDSFTDEDIRYKTRHAVKLKQMNKKQNCTRSRKKLSRIILPDSDSSEEENTANGREDPSAGGHAADKHTQQGQLWASGPSGSVQPKVLCNPAGNQSSGQRLQVLPNIMDAVPGALNVRAQSHNQTKSTSPPCASVESRKECGNRPVQLKVGDQDTSAAPCSASLLPDAEVLIAPRHPREGNRACILVDSREITTGLEVISSLRTVHGLQVEICPLNGCDYIVSNRMVVERKSQSEMLSNTAKNKFIEQIQRLQSMFQRICVIVEKDREKAGDISKMFRRTKCYDSLLTALVGAGIRILFSSGQEETAGLIKELSLVEQRKNAGIHIPAVLDTGTCEALQFYLSIPGVSYVTALNMCHQFSSVKKMVNSSPEEISTCAQVTHQKAEEIYKYIHYTFDMQMLPNDLTQERQKSETCSTL", "length": 2017, "header": "tr|A0A0G2K7F0-1|A0A0G2K7F0_RAT Isoform 1 of FA complementation group M OS=Rattus norvegicus OX=10116 GN=Fancm PE=3 SV=1 CANONICAL=A0A0G2K7F0-1" }, "locus": { "chromosome": "6", "start_pos": 83179791, "end_pos": 83127167, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000086081.2", "url": "https://www.ensembl.org/id/ENSRNOT00000086081.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000074177.1", "url": "https://www.ensembl.org/id/ENSRNOP00000074177.1" } ] } }, { "isoform_ac": "A0A1W2Q6G5-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K7F0/entry#A0A1W2Q6G5-1", "sequence": { "sequence": "MGSRGFLDEEAEVSGEDADCVSSDEGDDSENEKDSSLLDFVNDRTQLSQAINDSEMRAIYMKSVRSPLMSTKYKMVREKHNSMNIFSQIPEQDENYLEDSFCVAEEESCRSQSSEEEIFVDFNLTKDSFTDEDIRYKTRHAVKLKQMNKKQNCTRSRKKLSRIILPDSDSSEEENTANGREDPSAGGHAADKHTQQGQLWASGPSGSVQPKVLCNPAGNQSSGQRLQVLPNIMDAVPGALNVRAQSHNQTKSTSPPCASVESRKECGNRPVQLKVGDQDTSAAPCSASLLPDAEVLIAPRHPREGNRACILVDSREITTGLEVISSLRTVHGLQVEICPLNGCDYIVSNRMVVERKSQSEMLSNTAKNKFIEQIQRLQSMFQRICVIVEKDREKAGDISKMFRRTKCYDSLLTALVGAGIRILFSSGQEETAGLIKELSLVEQRKNAGIHIPAVLDTGTCEALQFYLSIPGVSYVTALNMCHQFSSVKKMVNRKRQPAERFLCVYSFKADRSALDK", "length": 516, "header": "tr|A0A1W2Q6G5-1|A0A1W2Q6G5_RAT Computationally mapped isoform of FA complementation group M OS=Rattus norvegicus OX=10116 GN=Fancm PE=4 SV=2 CANONICAL=A0A0G2K7F0-1" }, "locus": { "chromosome": "6", "start_pos": 83177096, "end_pos": 83166147, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000093492.2", "url": "https://www.ensembl.org/id/ENSRNOT00000093492.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000076245.2", "url": "https://www.ensembl.org/id/ENSRNOP00000076245.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool": "isoglyp", "mining_tool": "", "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "start_pos": 235, "start_aa": "T", "end_pos": 235, "end_aa": "T", "residue": "Thr", "site_lbl": "Thr235", "evidence": [ { "id": "GLY_001157", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001157" } ], "filter_code": "00000000000000001000.00000000001000.1.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-RNO-6783310", "name": "Fanconi Anemia Pathway", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6783310", "resource": "Reactome", "description": "Fanconi Anemia Pathway" }, { "id": "R-RNO-9833482", "name": "PKR-mediated signaling", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9833482", "resource": "Reactome", "description": "PKR-mediated signaling" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A3Q1LT80-1", "protein_name": "FA complementation group M", "gene_name": "FANCM", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MSGRQRTLFQTWGSKVSRSTGAPTCNSGTERPQSTGISRARFPAVAEAAGAAEVEPESDDDVLLVAVYEAERQLNLENGGFCTSAGALWIYPTNCPVRDYQLHIARTALFCNTLVCLPTGLGKTFIAAVVMYNFYRWFPSGKVVFMAPTKPLVTQQIEACYRVMGIPQSHMAEMTGSTQAFTRKEIWSSKRVLFLTPQVMVNDLSRGACPAAEIKCLVIDEAHKALGNYAYCQVVRELVKYTNHFRVLALSATPGSDIKAVQQVITNLLIGQIELRSEDSPDILPYSHERRVEKLVVPLGEELEAIQKAYIQILEAFASSLIQRNVLMRKDIPNLTKYQIILARDQFRKNPSPNIVGIQQGIIEGEFAICISLYHGYELLQQMGMRSLYFFLCGIMDGTKGMTRAKNELSRNADFMKLYDHLDSMFSHTRSTSTSGVSAIQKGGKDKKFCYSHPKLKKLEEVVVEHFKSWNARKTSDKKCDETRVMIFSSFRDSVQEIAEMLLPHQPIIRVMTFVGHASGKSMKGFTQKEQLEVVKQFRSGGYNTLVSTCVGEEGLDIGEVDLIICFDAQKSPIRLIQRMGRTGRKRQGRIVVILAEGREERTYNQSQCNKRSIYKAISGNRQVLHFYQGSPRMVPDGVNPQLHKMFITHGVYEPEKPSRNLPRKSSIFSYRNGIKQSNSKDDWFLSEEEFKLWNRRYRLRDTDEIQQITLPQVQFLSLHNEENRPTEEPTVGIRQLSLSEWRLWQDHPLPTYQVDHSDRCHHFINIMQMIEGMRHEEGECSYESEIKSYLRMEDVSSASSALRNEYNSFADGTFTNNRKSSFANINHRKSVSMTESDEECTEIFKQIPIKSTKIPSLKKKASENLKKDQPKKENKDVVMEPLDTDDSPTTEHILQVDPRNGERVSDTGEVTATCAVSENGGNPSCGLLTDCQFTIKSTGSFTGSFFDSGYNSFSDEKSFSASLFLSFEGELDIAKTDDQFFHCHSLTKEVLANVERFLSHSPPPLSGLSDLENEISEGSALENLVFLPYSECLQNDKSTNLMACSAVNSQQNLKFITHLSEKTCIYGTTNDKISDEPSFCDSDKVHKDSKNEHLVSSNQIQINISPSKDFAEEKNHDVDNSDLPILHTAQDESLLLFEDVNTEFNDVSPPPLNSKCESLGISDRTAVSEMAPVSQFFISDELLLENDSEPQDQIVCDTNSWKSHEGLRGRHEGKLNNDENGFDCSKDLFSVTFDLGFCSTGSEDEVVDHASDTNNEILDDLPGRRLDIKQINSTNCVSNQAVMSGAHVDNSTSVTTTHPSSEDKQTPAFSCFSMNATKSKEFMSPSYSQFLLPVGDKVMSTPLSESNILNSFSEKRMEMAKKSGSNMGKVNLHSFKETLNSTFGDSGLSTGKYKSKKQINLHQACHSTEDEQLSTHESEDDEIFRRKSKKTKGNVLESPENQKNSEVDSPLQVVKKHRVPPNRLDLSSSDESDNFHKRDPQSEDFTDHKRNAKRSIKVQKRQNHLKLVARKFLDEEAELSQEDAEYVSSDENDESEGEQDSSLLDFLNDETQLSQAINDSEMRAVYMKSVRSPLMSNRYKMAHKKHNINIFSQIPEQDETYLEDSFCVDEEESCESQSSEEVCVDFNLITEDCDTNESKKYKTRRAVKLKQMKMRQNCARSKNKLSRIILLDDSSEEEKDVKDKQESRTVVNPSTVPPGSSLQSRDHSHPVDNQLLHQRQQTPPNLKVPDSDVSDFKPQSLTNTESASSLFTAVGAQEDCRKFPVQLKGASALQDSGTCVPCCSNSRPRLADTHASLRLPQEGHRTCILVDSREIVSGSEVVSSLRAIHGLQVEVCPLNGCDYIVSNRMVVERRSQSEMLNSINKNKLIDQIQYLQSMFERICVIVEKDREKTGDTSRMFRRTKSYDSLLATLIGAGIRILFSSCQEETADLLKELSLVEQRKNVGIHVPTVVNSNICETLQFYLSIPNISYITALNMCHQFSSVKKMTNSTPQEISMYAQVTHQKAEEIYRYIHYIFDMQMLPADLNQADLLTQGSNLSF", "length": 2042 }, "evidence": [ { "id": "A0A0G2K7F0", "url": "https://omabrowser.org/oma/group/A0A0G2K7F0/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "Q8BGE5-1", "protein_name": "Fanconi anemia group M protein homolog", "gene_name": "Fancm", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSGRQRTLFQTWGPSLVRGSGDSGCGQPRSPAMAEALPEEDDEVLLVAAYEAERQLDPGDGGFCAAAGALWIYPTNCPVRDYQLDISRSALFCNTLVCLPTGLGKTFIAAVVMYNFYRWFPSGKVVFMAPTKPLVTQQMEACFHVMGIPQSHMAEMTGSTQAVNRKEIWSSRRVLFLTPQVMVNDLTRGAVPATHVKCLVVDEAHKALGNYAYCQVVRELVKYTTHFRILALSATPGSDIKAVQQVITNLLIGKIELRSEESPDILPYSHERRVEKLVVPLGEELGAIQKTYIQILETFASSLIHRNVLMKRDIPNLTKYQIILARDQFRKNPSPNIVGIQQGIIEGEFALCISLYHGYELLQQMGMRSLYFFLSGIMDGTKGMTRARNELSRNEDFMKLYTHLQSAFAPASTSDASAFQRGNKEKKFVYSHPKLKKLEEVILEHFKSWNAKATTEKKCHESRVMIFSSFRDSVEEIAEMLLQHRPVIRVMTFVGHASGKNTKGFTQKEQLQVVRQFRDGGYNTLVSTCVGEEGLDIGEVDLIICFDAQKSPIRLIQRMGRTGRKRQGRIVVILAEGREERTYNQSQSNKKNIYKAISGNRQVLRLYQGSPRMVPDKINPELHKMYITHGVYEPEKARSVQRRPFSSRGGIKASKSNKDGLLSEEEFNLWSRLYRLGDSDQVKGVALPQSHFPSLQEDRVIQDPTTRIHQLSLSEWSLWQDRPLPTHQVDHSDRCHHFISIMKMIEGMRHEEGECSYELKIRPFLQMEDVCSKYHAPRNGYNNVASVASSAHQKSSFRPSVDAGGSLTVIESEEEHADTVKQRDSKWTKITSLREKPCRAGRKGQTCEHSEGEGEDGDAGSSDADGQSPAEADSQVDPPSGERMADVGGISILGAVTEEDNHPGTLQMECQVTNKSCARYSLDSGYSSFSDEKSVSSNLFLPLEEELFTDRAAEQFYNCRPMTEDVLANVERFLSRSPPSLSGLSDLVYDVTQGCEFDNASCSPYPEHEHSPRPVSPASHSAGNSQQNLESNSAKRISHPTEKYCLPGTTHNKVSDRPSFCESDSEGHNIKYQNSGSNSCAQIQADLENNFVDKNSHDDSEPPVLFTDEDESLLLFEDDFKNIEDGPEELNGASLPPFNSISQPLRVSGKTLTSEMPPVSHFLISDELLLDDDSEPEDQIVCGAKSWKCQEGVEDGQEELRTDGQTFDCSVDLFSVTFDLGFRCSSGSDDEMLAGASDRTRTLGAADVSGRHSDKEIKDAGGASGPLGRAISPIPTETAQWSPWAQNKEYASFHVASSSPVKQRVRSTPLSKSHASSKTGAHMLKTLDSTKEKAGGQGFKMALNPRLGHLGFSVEETKSSDQVFVHQSPRRTEVEHLTSESEDDVFLRKTKKPKRNVLKSPEDQKNNEVDSPIHAVKKPRVLRSELASSDDESENFGRTCPRLEHFKGRNRNIRKGSAAQKNRSQVKTMARRFLDDEAEVSGEDVDCVSADEEDESENEQDSSLLDFVNDRTQLSQAINDSEMRAIYMKSVRSPLMSTKYRMVREKRPNMNIFSQIPEQDENYLEDSFCVDEEESCKSQSSEEEISVDFNLTKDSFTDEDIRYKTRYAVKIKQMNKKQNYTRPRKKLSRIILPDDDSSEEENIPKDREHSVAGGHAAAEHTQQGQLWASGPSGSSVPPQVLSDPSWNQSSRQRLQVQPSITDAVPRTLNVKAQSHNKIKSASPPCTGVESRKEYGNHPVQLKADSQEHSDTSAAPCSTSLLHVAEGHTAPRHLQEGNRACILVDSREITTGLEVISSLRTVHGLQVEICPLNGCDYIVSSRMVVVRRSQSEMLSNTSKNKFIEQMQRLQSMFQRICVIVEKDREKAGDTSKKFRRTKCYDSLLTALVGAGIRILFSSGQEETADLLKELSLVEQRKNAGIHIPAVLNTSKLEALPFYLSIPGISYITALNMCHQFSSVKKMANSSPEEISTCAQVNHQKAEEIYKYIHYIFDMQMLPNDLNQERQKPDTCLTLGVAMKELS", "length": 2021 }, "evidence": [ { "id": "A0A0G2K7F0", "url": "https://omabrowser.org/oma/group/A0A0G2K7F0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8IYD8-1", "protein_name": "Fanconi anemia group M protein", "gene_name": "FANCM", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSGRQRTLFQTWGSSISRSSGTPGCSSGTERPQSPGSSKAPLPAAAEAQLESDDDVLLVAAYEAERQLCLENGGFCTSAGALWIYPTNCPVRDYQLHISRAALFCNTLVCLPTGLGKTFIAAVVMYNFYRWFPSGKVVFMAPTKPLVTQQIEACYQVMGIPQSHMAEMTGSTQASTRKEIWCSKRVLFLTPQVMVNDLSRGACPAAEIKCLVIDEAHKALGNYAYCQVVRELVKYTNHFRILALSATPGSDIKAVQQVITNLLIGQIELRSEDSPDILTYSHERKVEKLIVPLGEELAAIQKTYIQILESFARSLIQRNVLMRRDIPNLTKYQIILARDQFRKNPSPNIVGIQQGIIEGEFAICISLYHGYELLQQMGMRSLYFFLCGIMDGTKGMTRSKNELGRNEDFMKLYNHLECMFARTRSTSANGISAIQQGDKNKKFVYSHPKLKKLEEVVIEHFKSWNAENTTEKKRDETRVMIFSSFRDSVQEIAEMLSQHQPIIRVMTFVGHASGKSTKGFTQKEQLEVVKQFRDGGYNTLVSTCVGEEGLDIGEVDLIICFDSQKSPIRLVQRMGRTGRKRQGRIVIILSEGREERIYNQSQSNKRSIYKAISSNRQVLHFYQRSPRMVPDGINPKLHKMFITHGVYEPEKPSRNLQRKSSIFSYRDGMRQSSLKKDWFLSEEEFKLWNRLYRLRDSDEIKEITLPQVQFSSLQNEENKPAQESTTGIHQLSLSEWRLWQDHPLPTHQVDHSDRCRHFIGLMQMIEGMRHEEGECSYELEVESYLQMEDVTSTFIAPRNESNNLASDTFITHKKSSFIKNINQGSSSSVIESDEECAEIVKQTHIKPTKIVSLKKKVSKEIKKDQLKKENNHGIIDSVDNDRNSTVENIFQEDLPNDKRTSDTDEIAATCTINENVIKEPCVLLTECQFTNKSTSSLAGNVLDSGYNSFNDEKSVSSNLFLPFEEELYIVRTDDQFYNCHSLTKEVLANVERFLSYSPPPLSGLSDLEYEIAKGTALENLLFLPCAEHLRSDKCTCLLSHSAVNSQQNLELNSLKCINYPSEKSCLYDIPNDNISDEPSLCDCDVHKHNQNENLVPNNRVQIHRSPAQNLVGENNHDVDNSDLPVLSTDQDESLLLFEDVNTEFDDVSLSPLNSKSESLPVSDKTAISETPLVSQFLISDELLLDNNSELQDQITRDANSFKSRDQRGVQEEKVKNHEDIFDCSRDLFSVTFDLGFCSPDSDDEILEHTSDSNRPLDDLYGRYLEIKEISDANYVSNQALIPRDHSKNFTSGTVIIPSNEDMQNPNYVHLPLSAAKNEELLSPGYSQFSLPVQKKVMSTPLSKSNTLNSFSKIRKEILKTPDSSKEKVNLQRFKEALNSTFDYSEFSLEKSKSSGPMYLHKSCHSVEDGQLLTSNESEDDEIFRRKVKRAKGNVLNSPEDQKNSEVDSPLHAVKKRRFPINRSELSSSDESENFPKPCSQLEDFKVCNGNARRGIKVPKRQSHLKHVARKFLDDEAELSEEDAEYVSSDENDESENEQDSSLLDFLNDETQLSQAINDSEMRAIYMKSLRSPMMNNKYKMIHKTHKNINIFSQIPEQDETYLEDSFCVDEEESCKGQSSEEEVCVDFNLITDDCFANSKKYKTRRAVMLKEMMEQNCAHSKKKLSRIILPDDSSEEENNVNDKRESNIAVNPSTVKKNKQQDHCLNSVPSGSSAQSKVRSTPRVNPLAKQSKQTSLNLKDTISEVSDFKPQNHNEVQSTTPPFTTVDSQKDCRKFPVPQKDGSALEDSSTSGASCSKSRPHLAGTHTSLRLPQEGKGTCILVGGHEITSGLEVISSLRAIHGLQVEVCPLNGCDYIVSNRMVVERRSQSEMLNSVNKNKFIEQIQHLQSMFERICVIVEKDREKTGDTSRMFRRTKSYDSLLTTLIGAGIRILFSSCQEETADLLKELSLVEQRKNVGIHVPTVVNSNKSEALQFYLSIPNISYITALNMCHQFSSVKRMANSSLQEISMYAQVTHQKAEEIYRYIHYVFDIQMLPNDLNQDRLKSDI", "length": 2048 }, "evidence": [ { "id": "A0A0G2K7F0", "url": "https://omabrowser.org/oma/group/A0A0G2K7F0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "resolution of meiotic recombination intermediates", "id": "GO:0000712", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000712", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K7F0", "url": "https://www.uniprot.org/uniprot/A0A0G2K7F0" } ], "pmid": "" }, { "name": "interstrand cross-link repair", "id": "GO:0036297", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036297", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K7F0", "url": "https://www.uniprot.org/uniprot/A0A0G2K7F0" } ], "pmid": "" }, { "name": "replication fork processing", "id": "GO:0031297", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031297", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K7F0", "url": "https://www.uniprot.org/uniprot/A0A0G2K7F0" } ], "pmid": "" }, { "name": "positive regulation of protein monoubiquitination", "id": "GO:1902527", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902527", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K7F0", "url": "https://www.uniprot.org/uniprot/A0A0G2K7F0" } ], "pmid": "" }, { "name": "double-strand break repair via synthesis-dependent strand annealing", "id": "GO:0045003", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045003", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K7F0", "url": "https://www.uniprot.org/uniprot/A0A0G2K7F0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "Fanconi anaemia nuclear complex", "id": "GO:0043240", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043240", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K7F0", "url": "https://www.uniprot.org/uniprot/A0A0G2K7F0" } ], "pmid": "" }, { "name": "FANCM-MHF complex", "id": "GO:0071821", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071821", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K7F0", "url": "https://www.uniprot.org/uniprot/A0A0G2K7F0" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K7F0", "url": "https://www.uniprot.org/uniprot/A0A0G2K7F0" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K7F0", "url": "https://www.uniprot.org/uniprot/A0A0G2K7F0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 8, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K7F0", "url": "https://www.uniprot.org/uniprot/A0A0G2K7F0" } ], "pmid": "" }, { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K7F0", "url": "https://www.uniprot.org/uniprot/A0A0G2K7F0" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K7F0", "url": "https://www.uniprot.org/uniprot/A0A0G2K7F0" } ], "pmid": "" }, { "name": "helicase activity", "id": "GO:0004386", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004386", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K7F0", "url": "https://www.uniprot.org/uniprot/A0A0G2K7F0" } ], "pmid": "" }, { "name": "nuclease activity", "id": "GO:0004518", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004518", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K7F0", "url": "https://www.uniprot.org/uniprot/A0A0G2K7F0" } ], "pmid": "" }, { "name": "3'-5' DNA helicase activity", "id": "GO:0043138", "url": 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