{ "uniprot_canonical_ac": "A0A0G2K764-1", "uniprot_ac": "A0A0G2K764", "uniprot_id": "A0A0G2K764_RAT", "mass": { "chemical_mass": 71388.0, "monoisotopic_mass": 71388.0 }, "refseq": {}, "gene_names": [ { "name": "Txnrd3", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A0G2K764", "id": "A0A0G2K764" } ], "protein_names": [ { "name": "thioredoxin-disulfide reductase", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K764/entry#names_and_taxonomy", "id": "A0A0G2K764" }, { "name": "1.8.1.9", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K764/entry#names_and_taxonomy", "id": "A0A0G2K764" } ], "function": [], "disease": [ { "disease_id": "DOID:0050860", "recommended_name": { "id": "DOID:0050860", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050860", "name": "colorectal adenoma", "description": "An intestinal benign neoplasm that has_material_basis_in epithelial tissue of glandular origin and is located_in colon and located_in rectum." }, "synonyms": [], "evidence": [ { "id": "0050860", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0050860" } ] }, { "disease_id": "DOID:0080199", "recommended_name": { "id": "DOID:0080199", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080199", "name": "colorectal carcinoma", "description": "A colorectal cancer that arises from the colon or rectum and invades through the muscularis mucosa into the submucosa." }, "synonyms": [], "evidence": [ { "id": "0080199", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0080199" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K764", "url": "https://www.uniprot.org/uniprot/A0A0G2K764" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "gene": [ { "name": "Txnrd3", "url": "https://www.uniprot.org/uniprot/A0A0G2K764", "locus": { "chromosome": "4", "start_pos": 122112491, "end_pos": 122072548, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000059810", "url": "https://www.ensembl.org/id/ENSRNOG00000059810" } ] } } ], "crossref": [ { "id": "A0A0G2K764", "url": "https://alphafold.ebi.ac.uk/entry/A0A0G2K764", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSRNOG00000059810", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000059810", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd03419", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03419", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001100", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001100", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002109", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002109", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004099", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004099", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006338", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006338", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011899", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011899", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012999", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012999", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016156", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016156", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023753", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023753", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036188", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036188", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036249", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036249", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046952", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046952", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "HPTCGEI", "url": "https://omabrowser.org/oma/group/HPTCGEI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR42737", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42737", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR42737:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42737:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00462", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00462", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF02852", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02852", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF07992", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07992", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "1308363", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1308363", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "20345", "url": "https://www.rhea-db.org/rhea/20345", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A0G2K0G3", "url": "https://www.uniprot.org/uniprot/A0A0G2K0G3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2K0G3-1", "url": "https://www.uniprot.org/uniprot/A0A0G2K0G3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2K764", "url": "https://www.uniprot.org/uniprot/A0A0G2K764", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2K764-1", "url": "https://www.uniprot.org/uniprot/A0A0G2K764-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "LEKPPSPPPPPRAQTSPGQGKAGVVPNRRLGAVRGGLMSSPPGRRARLTSPGTSRPPAEVREEVRRRLRDLIEGNRVMIFSKSYCPHSSRVKELFSSLGVNYYILELDQVDDGANVQEVLTEISNQKTVPNIFVNKVHVGGCDRIFQAHQNGLLQKLLQDDSTHDYDLIVIGGGSGGLSCAKEAANLGKKVMVLDFVVPSPQGTSWGLGGTCVNVGCIPKKLMHQAALLGHALQDARKYGWDYNQQVKHNWETMREAIQNHIGSLNWGYRVTLREKGVTYVNSFGEFVELHKIKATNKKGQETFYTASKFVIATGERPRYLGIQGDKEYCITSDDLFSLPYCPGNTLIVGASYVGLECAGFLAGLGLDVTVMVRSVLLRGFDQEMAEKVGSYLEQQGVKFQRKFTPILVQQLEKGLPGRLKVVAKSTEGPETVEGTYNTVLLAIGRDSCTRKIGLEKIGVKINEKNGKIPVNDVEQTNVPHVYAIGDVLEGKPELTPVAIQAGKLLARRLFGISLEKCDYINVPTTVFTPLEYGCCGLSEEKAIEMYTKENLEVYHTFFWPLEWTVAGRDNNTCYAKIICNKFDNDRVIGFHLLGPNAGEVTQGFAAAMKCGLTKQLLDDTIGIHPTCGEVFTTMEITKSSGLDITQKGC", "length": 650, "header": "tr|A0A0G2K764-1|A0A0G2K764_RAT Isoform 1 of thioredoxin-disulfide reductase OS=Rattus norvegicus OX=10116 GN=Txnrd3 PE=1 SV=2 CANONICAL=A0A0G2K764-1" }, "isoforms": [ { "isoform_ac": "A0A0G2K0G3-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K764/entry#A0A0G2K0G3-1", "sequence": { "sequence": "MSSPPGRRARLTSPGTSRPPAEVREEVKELFSSLGVNYYILELDQVDDGANVQEVLTEISNQKTVPNIFVNKVHVGGCDRIFQAHQNGLLQKLLQDDSTHDYDLIVIGGGSGGLSCAKEAANLGKKVMVLDFVVPSPQGTSWGLGGTCVNVGCIPKKLMHQAALLGHALQDARKYGWDYNQQVKHNWETMREAIQNHIGSLNWGYRVTLREKGVTYVNSFGEFVELHKIKATNKKGQETFYTASKFVIATGERPRYLGIQGDKEYCITSDDLFSLPYCPGNTLIVGASYVGLECAGFLAGLGLDVTVMVRSVLLRGFDQEMAEKVGSYLEQQGVKFQRKFTPILVQQLEKGLPGRLKVVAKSTEGPETVEGTYNTVLLAIGRDSCTRKIGLEKIGVKINEKNGKIPVNDVEQTNVPHVYAIGDVLEGKPELTPVAIQAGKLLARRLFGISLEKCDYINVPTTVFTPLEYGCCGLSEEKAIEMYTKENLEVYHTFFWPLEWTVAGRDNNTCYAKIICNKFDNDRVIGFHLLGPNAGEVTQGFAAAMKCGLTKQLLDDTIGIHPTCGEVFTTMEITKSSGLDITQKGC", "length": 586, "header": "tr|A0A0G2K0G3-1|A0A0G2K764_RAT Computationally mapped isoform of thioredoxin-disulfide reductase OS=Rattus norvegicus OX=10116 GN=Txnrd3 PE=1 SV=2 CANONICAL=A0A0G2K764-1" }, "locus": { "chromosome": "4", "start_pos": 122111805, "end_pos": 122072804, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000077374.2", "url": "https://www.ensembl.org/id/ENSRNOT00000077374.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000071434.2", "url": "https://www.ensembl.org/id/ENSRNOP00000071434.2" } ] } }, { "isoform_ac": "A0A0G2K764-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K764/entry#A0A0G2K764-1", "sequence": { "sequence": "LEKPPSPPPPPRAQTSPGQGKAGVVPNRRLGAVRGGLMSSPPGRRARLTSPGTSRPPAEVREEVRRRLRDLIEGNRVMIFSKSYCPHSSRVKELFSSLGVNYYILELDQVDDGANVQEVLTEISNQKTVPNIFVNKVHVGGCDRIFQAHQNGLLQKLLQDDSTHDYDLIVIGGGSGGLSCAKEAANLGKKVMVLDFVVPSPQGTSWGLGGTCVNVGCIPKKLMHQAALLGHALQDARKYGWDYNQQVKHNWETMREAIQNHIGSLNWGYRVTLREKGVTYVNSFGEFVELHKIKATNKKGQETFYTASKFVIATGERPRYLGIQGDKEYCITSDDLFSLPYCPGNTLIVGASYVGLECAGFLAGLGLDVTVMVRSVLLRGFDQEMAEKVGSYLEQQGVKFQRKFTPILVQQLEKGLPGRLKVVAKSTEGPETVEGTYNTVLLAIGRDSCTRKIGLEKIGVKINEKNGKIPVNDVEQTNVPHVYAIGDVLEGKPELTPVAIQAGKLLARRLFGISLEKCDYINVPTTVFTPLEYGCCGLSEEKAIEMYTKENLEVYHTFFWPLEWTVAGRDNNTCYAKIICNKFDNDRVIGFHLLGPNAGEVTQGFAAAMKCGLTKQLLDDTIGIHPTCGEVFTTMEITKSSGLDITQKGC", "length": 650, "header": "tr|A0A0G2K764-1|A0A0G2K764_RAT Isoform 1 of thioredoxin-disulfide reductase OS=Rattus norvegicus OX=10116 GN=Txnrd3 PE=1 SV=2 CANONICAL=A0A0G2K764-1" }, "locus": { "chromosome": "4", "start_pos": 122111805, "end_pos": 122072693, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000084494.2", "url": "https://www.ensembl.org/id/ENSRNOT00000084494.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000074078.2", "url": "https://www.ensembl.org/id/ENSRNOP00000074078.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool": "isoglyp", "mining_tool": "", "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "start_pos": 627, "start_aa": "T", "end_pos": 627, "end_aa": "T", "residue": "Thr", "site_lbl": "Thr627", "evidence": [ { "id": "GLY_001157", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001157" } ], "filter_code": "00000000000000001000.00000000001000.1.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "journal": "Nat. Commun.", "date": "2012", "authors": "Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K0G3", "url": "https://www.uniprot.org/uniprot/A0A0G2K0G3" } ], "reference": [ { "type": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" } ] } ], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0AAA9TCT6-1", "protein_name": "thioredoxin-disulfide reductase", "gene_name": "TXNRD3", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "LAQPPPPPPPPPSRAQTFSTPGRGSSPSRRLGNVRGAAGPPSPPGRRARPPAPGAGRLSGAAREELRRRLLGLIEGHRVVIFSKTYCPHSTRVKELFSSLGVDCNILELDQVDEGASVQEALSEITSQRTVPSVFVNRVHVGGCDHTFQAHQSGLLQQLLQQDPAYDYDLIVIGGGSGGLSCAQEAAVLGRKVMVLDFVVPSPRGTAWGLGGTCVNVGCIPKKLMHQAALLGQALTDSRKFGWEYSQQVRHSWATMTEAIQSHIGSLSWGHRLALREKAVTYVNSFGEFVEHHKVKATNEKGQEVLYTAAKFVIATGERPRYLGIPGDREYCITSDDLFSLPYCPGATLVVGASYVALECAGFLAGLGLEVTVMVRSVLLRGFDQEMAEKVGASMQQLGVRFLRKFVPVEVQQLERGLPGRLKVVAKSTEGTETIEGIYNTVLLAIGRDSCTKKLGLEKIGVNVSEKTGKIPVNDEEQTSVSYVYAVGDVLEGKPQLTPVAVQAGKLLARRLFGGRSEKCDYVNVPTVVFTPLEYGCCGYSEEKAGEVYQAENLNVYHTLFWPLEWTVAGRDNNTCYAKIICNKLDNDRVIGFHVLGPNAGEITQGFAAAMKCGLTKQLLDDTIGIHPTCGEVFTTLEITKASGLDITQKGC", "length": 652 }, "evidence": [ { "id": "A0A0G2K764", "url": "https://omabrowser.org/oma/group/A0A0G2K764/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "Q86VQ6-1", "protein_name": "Thioredoxin reductase 3", "gene_name": "TXNRD3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MERSPPQSPGPGKAGDAPNRRSGHVRGARVLSPPGRRARLSSPGPSRSSEAREELRRHLVGLIERSRVVIFSKSYCPHSTRVKELFSSLGVECNVLELDQVDDGARVQEVLSEITNQKTVPNIFVNKVHVGGCDQTFQAYQSGLLQKLLQEDLAYDYDLIIIGGGSGGLSCAKEAAILGKKVMVLDFVVPSPQGTSWGLGGTCVNVGCIPKKLMHQAALLGQALCDSRKFGWEYNQQVRHNWETMTKAIQNHISSLNWGYRLSLREKAVAYVNSYGEFVEHHKIKATNKKGQETYYTAAQFVIATGERPRYLGIQGDKEYCITSDDLFSLPYCPGKTLVVGASYVALECAGFLAGFGLDVTVMVRSILLRGFDQEMAEKVGSYMEQHGVKFLRKFIPVMVQQLEKGSPGKLKVLAKSTEGTETIEGVYNTVLLAIGRDSCTRKIGLEKIGVKINEKSGKIPVNDVEQTNVPYVYAVGDILEDKPELTPVAIQSGKLLAQRLFGASLEKCDYINVPTTVFTPLEYGCCGLSEEKAIEVYKKENLEIYHTLFWPLEWTVAGRENNTCYAKIICNKFDHDRVIGFHILGPNAGEVTQGFAAAMKCGLTKQLLDDTIGIHPTCGEVFTTLEITKSSGLDITQKGCUG", "length": 643 }, "evidence": [ { "id": "A0A0G2K764", "url": "https://omabrowser.org/oma/group/A0A0G2K764/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "thioredoxin-disulfide reductase (NADPH) activity", "id": "GO:0004791", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004791", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K764", "url": "https://www.uniprot.org/uniprot/A0A0G2K764" } ], "pmid": "" }, { "name": "flavin adenine dinucleotide binding", "id": "GO:0050660", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050660", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K764", "url": "https://www.uniprot.org/uniprot/A0A0G2K764" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K764", "url": "https://www.uniprot.org/uniprot/A0A0G2K764" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K764", "url": "https://www.uniprot.org/uniprot/A0A0G2K764" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K764", "url": "https://www.uniprot.org/uniprot/A0A0G2K764" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K764", "url": "https://www.uniprot.org/uniprot/A0A0G2K764" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "cell redox homeostasis", "id": "GO:0045454", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045454", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K764", "url": "https://www.uniprot.org/uniprot/A0A0G2K764" } ], "pmid": "" }, { "name": "cellular oxidant detoxification", "id": "GO:0098869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098869", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K764", "url": "https://www.uniprot.org/uniprot/A0A0G2K764" } ], "pmid": "" }, { "name": "blastocyst formation", "id": "GO:0001825", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001825", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K764", "url": "https://www.uniprot.org/uniprot/A0A0G2K764" } ], "pmid": "" }, { "name": "glutathione metabolic process", "id": "GO:0006749", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006749", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K764", "url": "https://www.uniprot.org/uniprot/A0A0G2K764" } ], "pmid": "" }, { "name": "response to oxidative stress", "id": "GO:0006979", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006979", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K764", "url": "https://www.uniprot.org/uniprot/A0A0G2K764" } ], "pmid": "" }, { "name": "response to inorganic substance", "id": "GO:0010035", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010035", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K764", "url": "https://www.uniprot.org/uniprot/A0A0G2K764" } ], 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