{ "uniprot_canonical_ac": "A0A0G2K712-1", "uniprot_ac": "A0A0G2K712", "uniprot_id": "A0A0G2K712_RAT", "mass": { "chemical_mass": 93063.0, "monoisotopic_mass": 93063.0 }, "refseq": { "ac": "XP_008764990", "name": "TBC1 domain family member 5 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_008764990" }, "gene_names": [ { "name": "Tbc1d5", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A0G2K712", "id": "A0A0G2K712" }, { "name": "RGD1561626", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_008764990", "id": "XP_008764990" }, { "name": "Tbc1d5", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_008764990", "id": "XP_008764990" } ], "protein_names": [ { "name": "TBC1 domain family member 5 isoform X1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_008764990", "id": "XP_008764990" }, { "name": "TBC1 domain family, member 5", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K712/entry#names_and_taxonomy", "id": "A0A0G2K712" } ], "function": [], "disease": [ { "disease_id": "DOID:9970", "recommended_name": { "id": "DOID:9970", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9970", "name": "obesity", "description": "An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness." }, "synonyms": [ { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "inherited obesity", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "genetic obesity", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "genetic obesity (disease)", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "leanness, inherited, autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "monogenic obesity", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, association with, Autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, early-onset, susceptibility to, Autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, late-onset, Autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, mild, early-onset, Autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, severe, Autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, severe, and type II diabetes, Autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, susceptibility to, Autosomal recessive", "description": "" }, { "id": "MIM:601665", "resource": "MIM", "url": "https://www.omim.org/entry/601665", "name": "Obesity", "description": "Obesity" } ], "evidence": [ { "id": "9970", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:9970" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K712", "url": "https://www.uniprot.org/uniprot/A0A0G2K712" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "gene": [ { "name": "Tbc1d5", "url": "https://www.uniprot.org/uniprot/A0A0G2K712", "locus": { "chromosome": "9", "start_pos": 3513623, "end_pos": 4016913, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000010637", "url": "https://www.ensembl.org/id/ENSRNOG00000010637" } ] } } ], "crossref": [ { "id": "A0A0G2K712", "url": "https://alphafold.ebi.ac.uk/entry/A0A0G2K712", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSRNOG00000010637", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000010637", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "501088", "url": "https://www.ncbi.nlm.nih.gov/gene/501088", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000195", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000195", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035969", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035969", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:501088", "url": "https://www.genome.jp/dbget-bin/www_bget?rno:501088", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RSICWKX", "url": "https://omabrowser.org/oma/group/RSICWKX/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A0G2K712", "url": "https://www.orthodb.org/?gene=A0A0G2K712", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1M9Q1", "url": "https://www.orthodb.org/?gene=F1M9Q1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22957", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22957", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22957:SF686", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22957:SF686", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00566", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00566", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "XP_008764990", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_008764990", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "1561626", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1561626", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "A0A0G2K712", "url": "https://www.uniprot.org/uniprot/A0A0G2K712", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2K712-1", "url": "https://www.uniprot.org/uniprot/A0A0G2K712-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6AMF2", "url": "https://www.uniprot.org/uniprot/A0A8I6AMF2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6AMF2-1", "url": "https://www.uniprot.org/uniprot/A0A8I6AMF2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1M9Q1", "url": "https://www.uniprot.org/uniprot/F1M9Q1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1M9Q1-1", "url": "https://www.uniprot.org/uniprot/F1M9Q1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MYKSVSETRHPLQSEEQEVGIDPLFSYSNKPRGDSCQNGRGANSNLDCDGTFSSYMREWDDLFVNNNYLAAVRQKGINGQLRSSRFRSICWKLFLCVLPQDKSQWISRIKELRSWYSNIKEIHITNPRKVVGQQDLMINNPLSQDEGSLWNKFFQDKELRSMIEQDVRRTFPEMQFFQQENVRKILTDVLFCYARENEQLLYKQGMHELLAPIIFTLHCDHQAFLHASESAQPSEEMKTLLNPEYLEHDAYAMFSQLMETAEPWFSTFEHDGQKGKETLMPPIPFARPQDLGPTVAIVTKVNQIQDHLLKKHDTELYMHLNRLEIPPQIYGLRWVRLLFGREFPLQDLLVVWDALFADGLHLSLVDYVFTAMLLYIRDALISSNYQTCLGLLMHYPLIGDIHSLILKALFLRDPKRNPRPVTYQFHPNLDYYKARGADLMNKSRTNARGAPLNIHKVSNSLINFGRKLIAPASAPGSMGGPVPGSNSSSSFSAAVPFRTSAEAPRHHSQQQRQQQQQQQQQQQQQQQQQQQRLMKSESMPVQLNKGDVVTGSDAQVSVPVQALTDLQGQSPKTISSSPSMESLPGGREPPGSPPSSATKRDSFFSHIARSRSHSKAMGRKESEEELEAQISFLQGQLNDLDAMCKYCAKVMDMHLVNIQDVVLQENLEKEDQILVSLAGLKQIKDILKGSLRFNQSQLEAEENEQITIADDHYCSSGQDQGTQGPRAAKQASSEMPGCTGGATSDDFILVSKEDEGRRAKEAFSGQAQPLLTLRNTSGKSRVPTCSPLVFSDPLMGPASASSSNPSSSPDDDSSKDSGFTIVSPLDI", "length": 827, "header": "tr|A0A0G2K712-1|A0A0G2K712_RAT Isoform 1 of TBC1 domain family, member 5 OS=Rattus norvegicus OX=10116 GN=Tbc1d5 PE=1 SV=1 CANONICAL=A0A0G2K712-1" }, "isoforms": [ { "isoform_ac": "A0A0G2K712-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K712/entry#A0A0G2K712-1", "sequence": { "sequence": "MYKSVSETRHPLQSEEQEVGIDPLFSYSNKPRGDSCQNGRGANSNLDCDGTFSSYMREWDDLFVNNNYLAAVRQKGINGQLRSSRFRSICWKLFLCVLPQDKSQWISRIKELRSWYSNIKEIHITNPRKVVGQQDLMINNPLSQDEGSLWNKFFQDKELRSMIEQDVRRTFPEMQFFQQENVRKILTDVLFCYARENEQLLYKQGMHELLAPIIFTLHCDHQAFLHASESAQPSEEMKTLLNPEYLEHDAYAMFSQLMETAEPWFSTFEHDGQKGKETLMPPIPFARPQDLGPTVAIVTKVNQIQDHLLKKHDTELYMHLNRLEIPPQIYGLRWVRLLFGREFPLQDLLVVWDALFADGLHLSLVDYVFTAMLLYIRDALISSNYQTCLGLLMHYPLIGDIHSLILKALFLRDPKRNPRPVTYQFHPNLDYYKARGADLMNKSRTNARGAPLNIHKVSNSLINFGRKLIAPASAPGSMGGPVPGSNSSSSFSAAVPFRTSAEAPRHHSQQQRQQQQQQQQQQQQQQQQQQQRLMKSESMPVQLNKGDVVTGSDAQVSVPVQALTDLQGQSPKTISSSPSMESLPGGREPPGSPPSSATKRDSFFSHIARSRSHSKAMGRKESEEELEAQISFLQGQLNDLDAMCKYCAKVMDMHLVNIQDVVLQENLEKEDQILVSLAGLKQIKDILKGSLRFNQSQLEAEENEQITIADDHYCSSGQDQGTQGPRAAKQASSEMPGCTGGATSDDFILVSKEDEGRRAKEAFSGQAQPLLTLRNTSGKSRVPTCSPLVFSDPLMGPASASSSNPSSSPDDDSSKDSGFTIVSPLDI", "length": 827, "header": "tr|A0A0G2K712-1|A0A0G2K712_RAT Isoform 1 of TBC1 domain family, member 5 OS=Rattus norvegicus OX=10116 GN=Tbc1d5 PE=1 SV=1 CANONICAL=A0A0G2K712-1" }, "locus": { "chromosome": "9", "start_pos": 3847478, "end_pos": 3514959, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000083387.2", "url": "https://www.ensembl.org/id/ENSRNOT00000083387.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000074017.1", "url": "https://www.ensembl.org/id/ENSRNOP00000074017.1" } ] } }, { "isoform_ac": "A0A8I6AMF2-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K712/entry#A0A8I6AMF2-1", "sequence": { "sequence": "MYKSVSETRHPLQSEEQEVGIDPLFSYSNKPRGDSCQNGRGANSNLDCDGTFSSYMREWDDLFVNNNYLAAVRQKGINGQLRSSRFRSICWKLFLCVLPQDKSQWISRIKELRSWYSNIKEIHITNPRKVVGQQDLMINNPLSQDEGSLWNKFFQDKELRSMIEQDVRRTFPEMQFFQQENVRKILTDVLFCYARENEQLLYKQGMHELLAPIIFTLHCDHQAFLHASESAQPSEEMKTLLNPEYLEHDAYAMFSQLMETAEPWFSTFEHDGQKGKETLMPPIPFARPQDLGPTVAIVTKVNQIQDHLLKKHDTELYMHLNRLEIPPQIYGLRWVRLLFGREFPLQDLLVVWDALFADGLHLSLVDYVFTAMLLYIRDALISSNYQTCLGLLMHYPLIGDIHSLILKALFLRDPKRNPRPVTYQFHPNLDYYKARGADLMNKSRTNARGAPLNIHKVSNSLINFGRKLIAPASAPGSMGGPVPGSNSSSSFSAAVPFRTSAEAPRHHSQQQRQQQQQQQQQQQQQQQQQQQRLMKSESMPVQLNKGDVVTGSDAQVSVPVQALTDLQGQSPKTISSSPSMESLPGGREPPGSPPSSATKRDSFFSHIARSRSHSKAMVCRFPWRRAPLMLINIQDVVLQENLEKEDQILVSLAGLKQIKDILKGSLRFNQSQLEAEENEQITIADDHYCSSGQDQGTQGPRAAKQASSEMPGCTGGATSDDFILVSKEDEGRRAKEAFSGQAQPLLTLRNTSGKSRVPTCSPLVFSDPLMGPASASSSNPSSSPDDDSSKDSGFTIVSPLDI", "length": 802, "header": "tr|A0A8I6AMF2-1|A0A8I6AMF2_RAT Computationally mapped isoform of TBC1 domain family, member 5 OS=Rattus norvegicus OX=10116 GN=Tbc1d5 PE=1 SV=1 CANONICAL=A0A0G2K712-1" }, "locus": { "chromosome": "9", "start_pos": 3847478, "end_pos": 3514959, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000112471.1", "url": "https://www.ensembl.org/id/ENSRNOT00000112471.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000094871.1", "url": "https://www.ensembl.org/id/ENSRNOP00000094871.1" } ] } }, { "isoform_ac": "F1M9Q1-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K712/entry#F1M9Q1-1", "sequence": { "sequence": "MYKSVSETRHPLQSEEQEVGIDPLFSYSNKPRGDSCQNGRGANSNLDCDGTFSSYMREWDDLFVNNNYLAAVRQKGINGQLRSSRFRSICWKLFLCVLPQDKSQWISRIKELRSWYSNIKEIHITNPRKVVGQQDLMINNPLSQDEGSLWNKFFQDKELRSMIEQDVRRTFPEMQFFQQENVRKILTDVLFCYARENEQLLYKQGMHELLAPIIFTLHCDHQAFLHASESAQPSEEMKTLLNPEYLEHDAYAMFSQLMETAEPWFSTFEHDGQKGKETLMPPIPFARPQDLGPTVAIVTKVNQIQDHLLKKHDTELYMHLNRLEIPPQIYGLRWVRLLFGREFPLQDLLVVWDALFADGLHLSLVDYVFTAMLLYIRDALISSNYQTCLGLLMHYPLIGDIHSLILKALFLRDPKRNPRPVTYQFHPNLDYYKARGADLMNKSRTNARGAPLNIHKVSNSLINFGRKLIAPASAPGSMGGPVPGSNSSSSFSAAVPFRTSAEAPRHHSQQQRQQQQQQQQQQQQQQQQQQQRLMKSESMPVQLNKGQSPKTISSSPSMESLPGGREPPGSPPSSATKRDSFFSHIARSRSHSKAMGRKESEEELEAQISFLQGQLNDLDAMCKYCAKVMDMHLVNIQDVVLQENLEKEDQILVSLAGLKQIKDILKGSLRFNQSQLEAEENEQITIADDHYCSSGQDQGTQGPRAAKQASSEMPGCTGGATSDDFILVSKEDEGRRAKEAFSGQAQPLLTLRNTSGKSRVPTCSPLVFSDPLMGPASASSSNPSSSPDDDSSKDSGFTIVSPLDI", "length": 805, "header": "tr|F1M9Q1-1|F1M9Q1_RAT Computationally mapped isoform of TBC1 domain family, member 5 OS=Rattus norvegicus OX=10116 GN=Tbc1d5 PE=1 SV=1 CANONICAL=A0A0G2K712-1" }, "locus": { "chromosome": "9", "start_pos": 3847478, "end_pos": 3514959, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000014171.7", "url": "https://www.ensembl.org/id/ENSRNOT00000014171.7" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000014171.5", "url": "https://www.ensembl.org/id/ENSRNOP00000014171.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool": "isoglyp", "mining_tool": "", "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "start_pos": 294, "start_aa": "T", "end_pos": 294, "end_aa": "T", "residue": "Thr", "site_lbl": "Thr294", "evidence": [ { "id": "GLY_001157", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001157" } ], "filter_code": "00000000000000001000.00000000001000.1.01000" } ], "phosphorylation": [ { "start_pos": 538, "end_pos": 538, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "F1M9Q1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/F1M9Q1" } ], "site_lbl": "Ser538" }, { "start_pos": 557, "end_pos": 557, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "F1M9Q1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/F1M9Q1" } ], "site_lbl": "Ser557" }, { "start_pos": 801, "end_pos": 801, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "F1M9Q1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/F1M9Q1" } ], "site_lbl": "Ser801" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "journal": "Nat. Commun.", "date": "2012", "authors": "Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K712", "url": "https://www.uniprot.org/uniprot/A0A0G2K712" } ], "reference": [ { "type": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" } ] } ], "pathway": [ { "id": "rno:501088", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?rno:501088", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0X5W4-1", "protein_name": "TBC1 domain family member 5", "gene_name": "TBC1D5", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MVTSKTSEGLQKIVREPPRRLLQYYKYPSVEIIANMYHSVSETSHPLQTEEQEVGIDPLQSYLNKTEEGGSNENGSTQHTSDSAGTFISYSKEWEELFVNNNYLATIRLKGINGQLRSSRFRSVCWKLFLEVLPQDRSQWIKNTSELRTSYNKIKEIHITNPRKAGQQDLIINNPLSQDEGSLWNKFFQDKELRAMIEQDVTRTFPEMQYFQQENVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFILHCDHQAFSHASEAAQPSEEMKVLLNPEYLEHDAYAMFTRLMKTAEHWFSTFEHDSQKEKDVMITPMPFARPQDLGPSIAIVTKVNQIQDQLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALFADSITLNLVDYIFVAMLLYIRDALISSNYQTCLGLLMHYPPIGDVHSLILRALFLRDPKKNPRPVTHQFQQNLDYYKARGADLMNKTRASAKAAPLNINKVSNSLLNFGRKLIAPAMASGSTAGPTAGTGSFPPTTGPTRGTTEAPQYHQHQAQQQRMMKSESMPVQLGKGQSSKISSSPSIESLPGGREFTGSPPLSASKKDSFFSTISRSRSQSKTMSRKESEEELEAQISFLQGQLNDLEAMCKYCAKMMNTHLGNIQEVILQEHLEKEDEILVSLAGLKQIKDILKGSLRFNQSQLEAEENEQITIADDHYCSNNQNKGTGDILKGSVMTKQQFISGRQTATHSSTSESKGADDCILVSKEEGSRNAVPEPAQLLQTFKESAVKPEAPSRPLVFSDPLMGSISASSSNLSSSPDDNSSNNSKDSDFAIVSPLDI", "length": 828 }, "evidence": [ { "id": "A0A0G2K712", "url": "https://omabrowser.org/oma/group/A0A0G2K712/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1N3C5-1", "protein_name": "TBC1 domain family member 5", "gene_name": "TBC1D5", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MYHSLSETRHPLQPEEQEVGTDPLSSYPDQPGGDSNQNGRTSSLDSDGTFNSYRKEWEELFVNNNYLATIRQKGINGQLRSSRFRSICWKLFLCVLPQDKSQWISKIKELRAWYSSVKEIHITNPRKAVGQQDLMINNPLSQDEGSLWNKFFQDKELRSMIEQDVKRTFPEMQFFQQESVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFTLHCDHQAFLHASESAQPSEEMKTLLNPEYLEHDAYAMFSQLMETAEPWFSTFEHDGQKGKETLMPPIPFARPQDLGPTIAIVTKVNQIQDQLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALFADGLTLTLVDYVFVAMLLYIRDALISSNYQTCLGLLMHYPLIGDVHSLILKALFLRDPKRNPRPVTYQFHPNLDYYKARGADLMNKSRTNAKGVPLNINKVSNSLINFGRKLISPAAAPGGAGGPVAAGGAGAPSPAAAPTRTLAEAPRHALQQQQQRLMKSESMPVQLNKGDVVTGSDAQVSVPVQTLTDLPGQSSKNISSSPSIESLPGGREFTGSPPSSAAKKDSFFSNISRSRSHSKTMGRRESEEELEAQISFLQGQLNDLDAMCKYCAKVMDTHLVNIQEVILQENLEKEDQILVSLAGLKQIKDILKGSLRFNQSQLEAEDNEQISISDDHYCSSGAAQQVPGSQGGAGPGGVHRGRGETPGRRERPGADDFVLVSKDCEERGAGLSPAGQAQPLRPLRGAARPVLVFSDPLTGPASASSSNPSSSPDDDSSGHSKDSGFTIVSPLDL", "length": 809 }, "evidence": [ { "id": "A0A0G2K712", "url": "https://omabrowser.org/oma/group/A0A0G2K712/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "Q80XQ2-1", "protein_name": "TBC1 domain family member 5", "gene_name": "Tbc1d5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MYKSVSETRHPLQSEEQEVGIDPLFSYSNKTRGDLSQNGRGSNSTLDTEGTFNSYMKEWEELFVNNNYLATVRQKGINGQLRSSRFRSICWKLFLCVLPQDKSQWISKIKELRAWYSSIKEIHITNPRKAAGQQDLMINNPLSQDEGSLWNKFFQDKELRSMIEQDVKRTFPEMQFFQQENVRKILTDVLFCYARENEQLLYKQGMHELLAPIIFTLHCDHQAFLHASESAQPSEEMKTLLNPEYLEHDAYAMFSQLMETAEPWFSTFEHDGQKGKETLMAPIPFARPQDLGPTVAIVTKVNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALFADSLNLSLVDYVFTAMLLYIRDALISSNYQTCLGLLMHYPIIGDIHSLILKALFLRDPKRNPRPATYQFHPNLDYYKARGADLMNKSRTNARGAPLNIHKVSNSLINFGRKLISPASAPGSMGGPVPGNNSSSSFSAAIPTRTSTEAPRHHLLQQQQQQQHQQQQQQQPQQQQQQHQQQQQQQRLMKSESMPVQLNKGQSSKTISSSPSIESLPGGREFTGSPPPSATKKDSFFSNIARSRSHSKTMGRKESEEELEAQISFLQGQLNDLDAMCKYCAKVMDMHLVNIQDVVLQENLEKEDQILVSLAGLKQIKDILKGSLRFNQSQLEAGENEQITIADDHYCSSGQDQGSQVPRAAKQASSEMPGCTGGTTPDDFILVSKEDEGHRARGAFSGQAQPLLTLRSTSGKSRAPACSPLLFSDPLMGPASASASSSNPSSSPDDDSSKESGFTIVSPLDI", "length": 815 }, "evidence": [ { "id": "47560532", "url": "http://www.informatics.jax.org/homology/47560532", "database": "MGI" }, { "id": "A0A0G2K712", "url": "https://omabrowser.org/oma/group/A0A0G2K712/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q92609-1", "protein_name": "TBC1 domain family member 5", "gene_name": "TBC1D5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MYHSLSETRHPLQPEEQEVGIDPLSSYSNKSGGDSNKNGRRTSSTLDSEGTFNSYRKEWEELFVNNNYLATIRQKGINGQLRSSRFRSICWKLFLCVLPQDKSQWISRIEELRAWYSNIKEIHITNPRKVVGQQDLMINNPLSQDEGSLWNKFFQDKELRSMIEQDVKRTFPEMQFFQQENVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDHQAFLHASESAQPSEEMKTVLNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGKETLMTPIPFARPQDLGPTIAIVTKVNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALFADGLSLGLVDYIFVAMLLYIRDALISSNYQTCLGLLMHYPFIGDVHSLILKALFLRDPKRNPRPVTYQFHPNLDYYKARGADLMNKSRTNAKGAPLNINKVSNSLINFGRKLISPAMAPGSAGGPVPGGNSSSSSSVVIPTRTSAEAPSHHLQQQQQQQRLMKSESMPVQLNKGLSSKNISSSPSVESLPGGREFTGSPPSSATKKDSFFSNISRSRSHSKTMGRKESEEELEAQISFLQGQLNDLDAMCKYCAKVMDTHLVNIQDVILQENLEKEDQILVSLAGLKQIKDILKGSLRFNQSQLEAEENEQITIADNHYCSSGQGQGRGQGQSVQMSGAIKQASSETPGCTDRGNSDDFILISKDDDGSSARGSFSGQAQPLRTLRSTSGKSQAPVCSPLVFSDPLMGPASASSSNPSSSPDDDSSKDSGFTIVSPLDI", "length": 795 }, "evidence": [ { "id": "47560532", "url": "http://www.informatics.jax.org/homology/47560532", "database": "MGI" }, { "id": "A0A0G2K712", "url": "https://omabrowser.org/oma/group/A0A0G2K712/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "GTPase activator activity", "id": "GO:0005096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K712", "url": "https://www.uniprot.org/uniprot/A0A0G2K712" } ], "pmid": "" }, { "name": "AP-2 adaptor complex binding", "id": "GO:0035612", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035612", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K712", "url": "https://www.uniprot.org/uniprot/A0A0G2K712" } ], "pmid": "" }, { "name": "protein-containing complex binding", "id": "GO:0044877", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044877", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K712", "url": "https://www.uniprot.org/uniprot/A0A0G2K712" } ], "pmid": "" }, { "name": "retromer complex binding", "id": "GO:1905394", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905394", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K712", "url": "https://www.uniprot.org/uniprot/A0A0G2K712" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K712", "url": "https://www.uniprot.org/uniprot/A0A0G2K712" } ], "pmid": "" }, { "name": "endosome membrane", "id": "GO:0010008", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010008", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K712", "url": "https://www.uniprot.org/uniprot/A0A0G2K712" } ], "pmid": "" }, { "name": "autophagosome", "id": "GO:0005776", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005776", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K712", "url": "https://www.uniprot.org/uniprot/A0A0G2K712" } ], "pmid": "" }, { "name": "AP-2 adaptor complex", "id": "GO:0030122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030122", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K712", "url": "https://www.uniprot.org/uniprot/A0A0G2K712" } ], "pmid": "" }, { "name": "Atg1/ULK1 kinase complex", "id": "GO:1990316", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990316", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K712", "url": "https://www.uniprot.org/uniprot/A0A0G2K712" } ], "pmid": "" }, { "name": "retromer complex", "id": "GO:0030904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030904", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K712", "url": "https://www.uniprot.org/uniprot/A0A0G2K712" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "response to starvation", "id": "GO:0042594", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042594", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K712", "url": "https://www.uniprot.org/uniprot/A0A0G2K712" } ], "pmid": "" }, { "name": "macroautophagy", "id": "GO:0016236", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016236", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K712", "url": "https://www.uniprot.org/uniprot/A0A0G2K712" } ], "pmid": "" }, { "name": "autophagy", "id": "GO:0006914", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006914", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K712", "url": "https://www.uniprot.org/uniprot/A0A0G2K712" } ], "pmid": "" }, { "name": "positive regulation of receptor internalization", "id": "GO:0002092", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002092", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K712", "url": "https://www.uniprot.org/uniprot/A0A0G2K712" } ], "pmid": "" }, { "name": "retrograde transport, endosome to Golgi", "id": "GO:0042147", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042147", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K712", "url": "https://www.uniprot.org/uniprot/A0A0G2K712" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 441, "end_pos": 443, "annotation": "n_glycosylation_sequon" }, { "start_pos": 486, "end_pos": 488, "annotation": "n_glycosylation_sequon" }, { "start_pos": 694, "end_pos": 696, "annotation": "n_glycosylation_sequon" }, { "start_pos": 775, "end_pos": 777, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A0G2K712-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 827, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A0G2K712-F1.pdb" } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 294 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 538, 557, 801 ], "sequon_annotation_sites": [ { "start_pos": 441, "end_pos": 443 }, { "start_pos": 486, "end_pos": 488 }, { "start_pos": 694, "end_pos": 696 }, { "start_pos": 775, "end_pos": 777 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "prediction_tool", "mining_tool", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { 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