{ "uniprot_canonical_ac": "A0A0G2K618-1", "uniprot_ac": "A0A0G2K618", "uniprot_id": "A0A0G2K618_RAT", "mass": { "chemical_mass": 87824.0, "monoisotopic_mass": 87824.0 }, "refseq": {}, "gene_names": [ { "name": "Large1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A0G2K618", "id": "A0A0G2K618" } ], "protein_names": [ { "name": "LARGE xylosyl- and glucuronyltransferase 1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K618/entry#names_and_taxonomy", "id": "A0A0G2K618" } ], "function": [], "disease": [ { "disease_id": "DOID:0050588", "recommended_name": { "id": "DOID:0050588", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050588", "name": "muscular dystrophy-dystroglycanopathy type B1", "description": "A congenital muscular dystrophy characterized by muscle weakness, cognitive impairment and brain abnormalities and has_material_basis_in mutation to the POMT1 gene that encodes O-mannosyltransferase." }, "synonyms": [ { "id": "DOID:0050588", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050588", "name": "CMD due to dystroglycanopathy", "description": "" }, { "id": "DOID:0050588", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050588", "name": "Muscular dystrophy-dystroglycanopathy congenital with impaired intellectual development B1", "description": "" }, { "id": "MONDO:0013159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013159", "name": "muscular dystrophy-dystroglycanopathy (congenital with intellectual disability), type B1", "description": "" }, { "id": "MONDO:0013159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013159", "name": "congenital muscular dystrophy-POMT1 related", "description": "" }, { "id": "MONDO:0013159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013159", "name": "MDDGB1", "description": "" }, { "id": "MONDO:0013159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013159", "name": "muscular dystrophy, congenital, Pomt1-related", "description": "" }, { "id": "MONDO:0013159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013159", "name": "muscular dystrophy-dystroglycanopathy (congenital with intellectual disability), type B, 1", "description": "" }, { "id": "MONDO:0013159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013159", "name": "muscular dystrophy-dystroglycanopathy (congenital with mental retardation), type B, 1", "description": "" }, { "id": "MIM:613155", "resource": "MIM", "url": "https://www.omim.org/entry/613155", "name": "Muscular dystrophy-dystroglycanopathy congenital with impaired intellectual development B1", "description": "Muscular dystrophy-dystroglycanopathy congenital with impaired intellectual development B1" } ], "evidence": [ { "id": "0050588", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0050588" } ] }, { "disease_id": "DOID:0110637", "recommended_name": { "id": "DOID:0110637", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110637", "name": "muscular dystrophy-dystroglycanopathy type B6", "description": "A congenital muscular dystrophy characterized by autosomal recessive inheritance of muscular dystrophy with mental retardation and structural brain abnormalities that has_material_basis_in homozygous or compound heterozygous mutation in the LARGE gene on chromosome 22q12." }, "synonyms": [ { "id": "DOID:0110637", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110637", "name": "MDC1D", "description": "" }, { "id": "DOID:0110637", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110637", "name": "MDDGB6", "description": "" }, { "id": "DOID:0110637", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110637", "name": "congenital muscular dystrophy LARGE-related", "description": "" }, { "id": "DOID:0110637", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110637", "name": "congenital muscular dystrophy type 1D", "description": "" }, { "id": "DOID:0110637", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110637", "name": "muscular dystrophy-dystroglycanopathy (congenital with mental retardation), type B, 6", "description": "" }, { "id": "DOID:0110637", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110637", "name": "muscular dystrophy-dystroglycanopathy (congenital with impaired intellectual development), type B, 6", "description": "" }, { "id": "MONDO:0012138", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012138", "name": "muscular dystrophy-dystroglycanopathy type B6", "description": "A congenital muscular dystrophy characterized by autosomal recessive inheritance of muscular dystrophy with mental retardation and structural brain abnormalities that has material basis in homozygous or compound heterozygous mutation in the LARGE gene on chromosome 22q12." }, { "id": "MONDO:0012138", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012138", "name": "MDC1D", "description": "" }, { "id": "MONDO:0012138", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012138", "name": "MDDGB6", "description": "" }, { "id": "MONDO:0012138", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012138", "name": "congenital muscular dystrophy large-related", "description": "" }, { "id": "MONDO:0012138", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012138", "name": "congenital muscular dystrophy type 1D", "description": "" }, { "id": "MONDO:0012138", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012138", "name": "muscular dystrophy-dystroglycanopathy (congenital with intellectual disability), type B, 6", "description": "" }, { "id": "MONDO:0012138", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012138", "name": "muscular dystrophy-dystroglycanopathy (congenital with mental retardation), type B, 6", "description": "" }, { "id": "MONDO:0012138", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012138", "name": "muscular dystrophy, congenital, large-related", "description": "" }, { "id": "MONDO:0012138", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012138", "name": "muscular dystrophy, congenital, type 1D", "description": "" }, { "id": "MIM:608840", "resource": "MIM", "url": "https://www.omim.org/entry/608840", "name": "Muscular dystrophy-dystroglycanopathy congenital with impaired intellectual development B6", "description": "Muscular dystrophy-dystroglycanopathy congenital with impaired intellectual development B6" } ], "evidence": [ { "id": "0110637", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0110637" } ] }, { "disease_id": "DOID:0111242", "recommended_name": { "id": "DOID:0111242", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111242", "name": "congenital muscular dystrophy-dystroglycanopathy type A6", "description": "A congenital muscular dystrophy-dystroglycanopathy type A that has_material_basis_in homozygous or compound heterozygous mutation in LARGE on 22q12.3." }, "synonyms": [ { "id": "DOID:0111242", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111242", "name": "Walker-Warburg syndrome or muscle-eye-brain disease, LARGE-related", "description": "" }, { "id": "DOID:0111242", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111242", "name": "MDDGA6", "description": "" }, { "id": "DOID:0111242", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111242", "name": "congenital muscular dystrophy-dystroglycanopathy with brain and eye anomalies type A6", "description": "" }, { "id": "MONDO:0013158", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013158", "name": "muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A6", "description": "An autosomal recessive muscular dystrophy caused by mutations in the LARGE gene. It is associated with characteristic brain and eye malformations, profound mental retardation, and death usually in the first years of life." }, { "id": "MONDO:0013158", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013158", "name": "muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies) type A, 6", "description": "" }, { "id": "MONDO:0013158", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013158", "name": "MDDGA6", "description": "" }, { "id": "MONDO:0013158", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013158", "name": "Walker-Warburg syndrome or muscle-eye-brain disease, large-related", "description": "" }, { "id": "MONDO:0013158", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013158", "name": "muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A, 6", "description": "" }, { "id": "MIM:613154", "resource": "MIM", "url": "https://www.omim.org/entry/613154", "name": "Muscular dystrophy-dystroglycanopathy congenital with brain and eye anomalies A6", "description": "Muscular dystrophy-dystroglycanopathy congenital with brain and eye anomalies A6" } ], "evidence": [ { "id": "0111242", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0111242" } ] }, { "disease_id": "DOID:11727", "recommended_name": { "id": "DOID:11727", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11727", "name": "facioscapulohumeral muscular dystrophy", "description": "" }, "synonyms": [ { "id": "DOID:11727", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11727", "name": "Landouzy Dejerine muscular dystrophy", "description": "" }, { "id": "DOID:11727", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11727", "name": "Landouzy-Dejerine muscular dystrophy", "description": "" }, { "id": "DOID:11727", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11727", "name": "Muscular dystrophy, Landouzy-Dejerine", "description": "" } ], "evidence": [ { "id": "11727", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:11727" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "gene": [ { "name": "Large1", "url": "https://www.uniprot.org/uniprot/A0A0G2K618", "locus": { "chromosome": "19", "start_pos": 11603129, "end_pos": 12048930, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000013742", "url": "https://www.ensembl.org/id/ENSRNOG00000013742" } ] } } ], "crossref": [ { "id": "A0A0G2K618", "url": "https://alphafold.ebi.ac.uk/entry/A0A0G2K618", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSRNOG00000013742", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000013742", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06431", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06431", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR002495", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002495", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029044", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029044", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051292", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051292", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "GWNKVSY", "url": "https://omabrowser.org/oma/group/GWNKVSY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A0G2K618", "url": "https://www.orthodb.org/?gene=A0A0G2K618", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "D4A390", "url": "https://www.orthodb.org/?gene=D4A390", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12270", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12270", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12270:SF48", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12270:SF48", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01501", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01501", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF13896", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13896", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-5173105", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5173105", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "1308895", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1308895", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "57336", "url": "https://www.rhea-db.org/rhea/57336", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "67924", "url": "https://www.rhea-db.org/rhea/67924", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "68368", "url": "https://www.rhea-db.org/rhea/68368", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2K618-1", "url": "https://www.uniprot.org/uniprot/A0A0G2K618-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D4A390", "url": "https://www.uniprot.org/uniprot/D4A390", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D4A390-1", "url": "https://www.uniprot.org/uniprot/D4A390-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLGICRGRRKFLAASLTLLCIPALTWIYLFAGSLEDGKPVSLSPLESQAHSPRYTASSQRERESLEVRVREVEEENRALRRQLSLAQGQSPAHRRGNHSKTYSMEEGTGDSENQRAGIVAGNSSECGQQPAVEKCETIHVAIVCAGYNASRDVVTLVKSVLFHRNPLHFHLIADSIAEQILATLFQTWMVPAVRVDFYNADELKSEVSWIPNKHYSGIYGLMKLVLTKTLPANLERVIVLDTDITFATDIAELWAVFHKFKGQQVLGLVENQSDWYLGNLWKNHRPWPALGRGYNTGVILLLLDKLRKMKWEQMWRLTAERELMGMLSTSLADQDIFNAVIKQNPFLVYQLPCFWNVQLSDHTRSEQCYRDVSDLKVIHWNSPKKLRVKNKHVEFFRNLYLTFLEYDGNLLRRELFGCPSETDVNSENLQKQLSELDEDDLCYEFRRERFTVHRTHLYFLHYEFEPSADHTDVTLVAQLSMDRLQMLEAICKHWEGPISLALYLSDAEAQQFLRYAQGSEVLMSRQNVGYHIVYKEGQFYPVNFLRNVAMKHISTPYMFLSDIDFLPMYGLYEYLRKSVIQLDLANTKKAMIVPAFETLRYRLSFPKSKAELLSMLDMGTLFTFRYHVWTKGHAPTNFAKWRTATTPYQVEWEADFEPYVVVRRDCPEYDRRFVGFGWNKVAHIMELDAQEYEFTVLPNAYMIHMPHAPSFDITKFRSNKQYRVCLKTLKEEFQQDMSRRYGFAALKYLTAENNS", "length": 755, "header": "tr|A0A0G2K618-1|A0A0G2K618_RAT Isoform 1 of LARGE xylosyl- and glucuronyltransferase 1 OS=Rattus norvegicus OX=10116 GN=Large1 PE=3 SV=2 CANONICAL=A0A0G2K618-1" }, "isoforms": [ { "isoform_ac": "A0A0G2K618-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K618/entry#A0A0G2K618-1", "sequence": { "sequence": "MLGICRGRRKFLAASLTLLCIPALTWIYLFAGSLEDGKPVSLSPLESQAHSPRYTASSQRERESLEVRVREVEEENRALRRQLSLAQGQSPAHRRGNHSKTYSMEEGTGDSENQRAGIVAGNSSECGQQPAVEKCETIHVAIVCAGYNASRDVVTLVKSVLFHRNPLHFHLIADSIAEQILATLFQTWMVPAVRVDFYNADELKSEVSWIPNKHYSGIYGLMKLVLTKTLPANLERVIVLDTDITFATDIAELWAVFHKFKGQQVLGLVENQSDWYLGNLWKNHRPWPALGRGYNTGVILLLLDKLRKMKWEQMWRLTAERELMGMLSTSLADQDIFNAVIKQNPFLVYQLPCFWNVQLSDHTRSEQCYRDVSDLKVIHWNSPKKLRVKNKHVEFFRNLYLTFLEYDGNLLRRELFGCPSETDVNSENLQKQLSELDEDDLCYEFRRERFTVHRTHLYFLHYEFEPSADHTDVTLVAQLSMDRLQMLEAICKHWEGPISLALYLSDAEAQQFLRYAQGSEVLMSRQNVGYHIVYKEGQFYPVNFLRNVAMKHISTPYMFLSDIDFLPMYGLYEYLRKSVIQLDLANTKKAMIVPAFETLRYRLSFPKSKAELLSMLDMGTLFTFRYHVWTKGHAPTNFAKWRTATTPYQVEWEADFEPYVVVRRDCPEYDRRFVGFGWNKVAHIMELDAQEYEFTVLPNAYMIHMPHAPSFDITKFRSNKQYRVCLKTLKEEFQQDMSRRYGFAALKYLTAENNS", "length": 755, "header": "tr|A0A0G2K618-1|A0A0G2K618_RAT Isoform 1 of LARGE xylosyl- and glucuronyltransferase 1 OS=Rattus norvegicus OX=10116 GN=Large1 PE=3 SV=2 CANONICAL=A0A0G2K618-1" }, "locus": { "chromosome": "19", "start_pos": 11916561, "end_pos": 11604348, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000090886.2", "url": "https://www.ensembl.org/id/ENSRNOT00000090886.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000073641.2", "url": "https://www.ensembl.org/id/ENSRNOP00000073641.2" } ] } }, { "isoform_ac": "D4A390-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K618/entry#D4A390-1", "sequence": { "sequence": "MLGICRGRRKFLAASLTLLCIPALTWIYLFAGSLEDGKPVSLSPLESQAHSPRYTASSQRERESLEVRVREVEEENRALRRQLSLAQGQSPAHRRGNHSKTYSMEEGTGDSENQRAGIVAGNSSECGQQPAVEKCETIHVAIVCAGYNASRDVVTLVKSVLFHRANPLHFHLIADSIAEQILATLFQTWMVPAVRVDFYNADELKSEVSWIPNKHYSGIYGLMKLVLTKTLPANLERVIVLDTDITFATDIAELWAVFHKFKGQQVLGLVENQSDWYLGNLWKNHRPWPALGRGYNTGVILLLLDKLRKMKWEQMWRLTAERELMGMLSTSLADQDIFNAVIKQNPFLVYQLPCFWNVQLSDHTRSEQCYRDVSDLKTTDVGGHL", "length": 385, "header": "tr|D4A390-1|A0A0G2K618_RAT Computationally mapped isoform of LARGE xylosyl- and glucuronyltransferase 1 OS=Rattus norvegicus OX=10116 GN=Large1 PE=3 SV=2 CANONICAL=A0A0G2K618-1" }, "locus": { "chromosome": "19", "start_pos": 11916561, "end_pos": 11626317, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000064105.2", "url": "https://www.ensembl.org/id/ENSRNOT00000064105.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000059410.2", "url": "https://www.ensembl.org/id/ENSRNOP00000059410.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-RNO-5173105", "name": "O-linked glycosylation", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5173105", "resource": "Reactome", "description": "O-linked glycosylation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A480F6A1-1", "protein_name": "LARGE xylosyl- and glucuronyltransferase 1", "gene_name": "LARGE1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLGICRGRRKFLAASLTLLCIPAITWLYLFAGSLEDGKPVSLSPLESQPHSPRYTASSQRDRESLELRMREVEEENRALRRQLSLAQGRGHRRGNHSRTYSMEEGTGDSENLRAGIVAGNSSECGQQPVVEKCETIHVAIVCAGYNASRDVVTLVKSVLFHRRNPLHFHLIADSIAEQILATLFQTWMVPAVRVDFYNADELKSEVSWIPNKHYSGIYGLMKLVLTKTLPAKLERVIVLDTDITFATDIAELWAVFHKFKGQQVLGLVENQSDWYLGNLWKNHRPWPALGRGYNTGVILLLLDKLRKMKWEQMWRLTAERELMGMLSTSLADQDIFNAVIKQNPFLVYQLPCFWNVQLSDHTRSEQCYRDVSDLKVIHWNSPKKLRVKNKHVEFFRNLYLTFLEYDGNLLRRELFGCPSEADVNSENLQKQLSELDEDDLCYEFRRERFTVHRTHLYFLHYEYEPASDNTDVTLVAQLSMDRLQMLEAICKHWEGPISLALYLSDAEAQQFLRYAQGSEVLMGRHNVAYHIVYKEGQFYPVNLLRNVAMKHVGTPYMFLSDIDFLPMYGLYEYLRKSVIQLDLANTKKAMIVPAFETLRYRLSFPKSKAELLSMLDMGTLFTFRYHVWTKGHAPTNFAKWRTATTPYRVEWEADFEPYVVVRRDCPEYDRRFVGFGWNKVAHIMELDAQEYEFIVLPNAYMIHMPHAPSFDITKFRSNKQYRICLKTLKEEFQQDMSRRYGFAALKYLTAENNS", "length": 754 }, "evidence": [ { "id": "A0A0G2K618", "url": "https://omabrowser.org/oma/group/A0A0G2K618/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "E1BDI0-1", "protein_name": "LARGE xylosyl- and glucuronyltransferase 1", "gene_name": "LARGE1", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MLGVCRGRRKFLAASLTLLCIPAITWLYLFAGSFEDGKPVSLSPLEAQPHSPRYTASSQRERESLEVRVREVEEENRALRRQLSLAQGRSPSHRRGNHSKTYSMEEGTGDSENLHAGIVAGNSSECGQQPVVEKCETIHVAIVCAGYNASRDVVTLVKSVLFHRRNPLHFHLIADSIAEQILATLFQTWMVPAVRVDFYNADELKSEVSWIPNKHYSGIYGLMKLVLTKTLPANLERVIVLDTDITFATDIAELWAVFHKFKGQQVLGLVENQSDWYLGNLWKNHRPWPALGRGYNTGVILLLLDKLRKMKWEQMWRLTAERELMGMLSTSLADQDIFNAVIKQNPFLVYQLPCFWNVQLSDHTRSEQCYRDVSDLKVIHWNSPKKLRVKNKHVEFFRNLYLTFLEYDGNLLRRELFGCPSEADVNSENLQKQLSELDEDDLCYEFRRERFTVHRTHLYFLHYEYEPASDNTDVTLVAQLSMDRLQMLEAICKHWEGPVSLALYLSDAEAQQFLRYAQGSEVLMGRHNVAYHIVYKEGQFYPVNLLRNVAMKHVGTPYMFLSDIDFLPMYGLYEYLRKSVIQLDLANTKKAMIVPAFETLRYRLSFPKSKAELLSMLDMGTLFTFRYHVWTKGHAPTNFAKWRTATTPYRVEWEADFEPYVVVRRDCPEYDRRFVGFGWNKVAHIMELDAQEYEFIVLPNAYMIHMPHAPSFDITKFRSNKQYRICLKTLKEEFQQDMSRRYGFAALKYLTAENNS", "length": 756 }, "evidence": [ { "id": "A0A0G2K618", "url": "https://omabrowser.org/oma/group/A0A0G2K618/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "O95461-1", "protein_name": "Xylosyl- and glucuronyltransferase LARGE1", "gene_name": "LARGE1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLGICRGRRKFLAASLSLLCIPAITWIYLFSGSFEDGKPVSLSPLESQAHSPRYTASSQRERESLEVRMREVEEENRALRRQLSLAQGRAPSHRRGNHSKTYSMEEGTGDSENLRAGIVAGNSSECGQQPVVEKCETIHVAIVCAGYNASRDVVTLVKSVLFHRRNPLHFHLIADSIAEQILATLFQTWMVPAVRVDFYNADELKSEVSWIPNKHYSGIYGLMKLVLTKTLPANLERVIVLDTDITFATDIAELWAVFHKFKGQQVLGLVENQSDWYLGNLWKNHRPWPALGRGYNTGVILLLLDKLRKMKWEQMWRLTAERELMGMLSTSLADQDIFNAVIKQNPFLVYQLPCFWNVQLSDHTRSEQCYRDVSDLKVIHWNSPKKLRVKNKHVEFFRNLYLTFLEYDGNLLRRELFGCPSEADVNSENLQKQLSELDEDDLCYEFRRERFTVHRTHLYFLHYEYEPAADSTDVTLVAQLSMDRLQMLEAICKHWEGPISLALYLSDAEAQQFLRYAQGSEVLMSRHNVGYHIVYKEGQFYPVNLLRNVAMKHISTPYMFLSDIDFLPMYGLYEYLRKSVIQLDLANTKKAMIVPAFETLRYRLSFPKSKAELLSMLDMGTLFTFRYHVWTKGHAPTNFAKWRTATTPYRVEWEADFEPYVVVRRDCPEYDRRFVGFGWNKVAHIMELDVQEYEFIVLPNAYMIHMPHAPSFDITKFRSNKQYRICLKTLKEEFQQDMSRRYGFAALKYLTAENNS", "length": 756 }, "evidence": [ { "id": "A0A0G2K618", "url": "https://omabrowser.org/oma/group/A0A0G2K618/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9Z1M7-1", "protein_name": "Xylosyl- and glucuronyltransferase LARGE1", "gene_name": "Large1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLGICRGRRKFLAASLTLLCIPAITWIYLFAGSFEDGKPVSLSPLESQAHSPRYTASSQRERESLEVRVREVEEENRALRRQLSLAQGQSPAHHRGNHSKTYSMEEGTGDSENLRAGIVAGNSSECGQQPAVEKCETIHVAIVCAGYNASRDVVTLVKSVLFHRRNPLHFHLIADSIAEQILATLFQTWMVPAVRVDFYNADELKSEVSWIPNKHYSGIYGLMKLVLTKTLPANLERVIVLDTDITFATDIAELWAVFHKFKGQQVLGLVENQSDWYLGNLWKNHRPWPALGRGYNTGVILLLLDKLRKMKWEQMWRLTAERELMGMLSTSLADQDIFNAVIKQNPFLVYQLPCFWNVQLSDHTRSEQCYRDVSDLKVIHWNSPKKLRVKNKHVEFFRNLYLTFLEYDGNLLRRELFGCPSETDVNNENLQKQLSELDEDDLCYEFRRERFTVHRTHLYFLHYEFEPSADNTDVTLVAQLSMDRLQMLEAICKHWEGPISLALYLSDAEAQQFLRYAQGSEVLMSRQNVGYHIVYKEGQFYPVNLLRNVAMKHISTPYMFLSDIDFLPMYGLYEYLRKSVIQLDLANTKKAMIVPAFETLRYRLSFPKSKAELLSMLDMGTLFTFRYHVWTKGHAPTNFAKWRTATTPYQVEWEADFEPYVVVRRDCPEYDRRFVGFGWNKVAHIMELDAQEYEFTVLPNAYMIHMPHAPSFDITKFRSNKQYRICLKTLKEEFQQDMSRRYGFAALKYLTAENNS", "length": 756 }, "evidence": [ { "id": "A0A0G2K618", "url": "https://omabrowser.org/oma/group/A0A0G2K618/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 68, "go_terms": [ { "name": "skeletal muscle tissue regeneration", "id": "GO:0043403", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043403", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "skeletal muscle organ development", "id": "GO:0060538", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060538", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "protein modification process", "id": "GO:0036211", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036211", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "astrocyte differentiation", "id": "GO:0048708", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048708", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "protein glycosylation", "id": "GO:0006486", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006486", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "intracellular protein transport", "id": "GO:0006886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006886", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "plasma membrane organization", "id": "GO:0007009", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007009", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "neuromuscular synaptic transmission", "id": "GO:0007274", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007274", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "heart development", "id": "GO:0007507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007507", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "neuromuscular junction development", "id": "GO:0007528", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007528", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "memory", "id": "GO:0007613", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007613", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "post-translational protein modification", "id": "GO:0043687", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043687", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "muscle cell cellular homeostasis", "id": "GO:0046716", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046716", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "synapse organization", "id": "GO:0050808", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050808", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "neuromuscular process", "id": "GO:0050905", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050905", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "synaptic assembly at neuromuscular junction", "id": "GO:0051124", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051124", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "transmembrane transport", "id": "GO:0055085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055085", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "protein localization to plasma membrane", "id": "GO:0072659", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072659", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "acetylcholine receptor signaling pathway", "id": "GO:0095500", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0095500", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "neuron migration", "id": "GO:0001764", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001764", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "protein O-linked glycosylation", "id": "GO:0006493", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006493", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "protein targeting to membrane", "id": "GO:0006612", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006612", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "chemical synaptic transmission", "id": "GO:0007268", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007268", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "glycoprotein biosynthetic process", "id": "GO:0009101", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009101", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "myelination", "id": "GO:0042552", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042552", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "regulation of synaptic plasticity", "id": "GO:0048167", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048167", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "multicellular organism growth", "id": "GO:0035264", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035264", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "cytoskeleton organization", "id": "GO:0007010", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007010", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "brain development", "id": "GO:0007420", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007420", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "muscle organ development", "id": "GO:0007517", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007517", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "response to mechanical stimulus", "id": "GO:0009612", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009612", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "skeletal muscle fiber development", "id": "GO:0048741", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048741", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "retina development in camera-type eye", "id": "GO:0060041", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060041", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "blood vessel development", "id": "GO:0001568", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001568", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "cardiac muscle tissue development", "id": "GO:0048738", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048738", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "behavioral fear response", "id": "GO:0001662", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001662", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "sensory perception of sound", "id": "GO:0007605", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007605", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "retina vasculature development in camera-type eye", "id": "GO:0061298", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061298", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "protein localization", "id": "GO:0008104", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008104", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "retina layer formation", "id": "GO:0010842", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010842", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "limb development", "id": "GO:0060173", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060173", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "bone development", "id": "GO:0060348", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060348", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "protein localization to membrane", "id": "GO:0072657", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072657", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "striated muscle contraction", "id": "GO:0006941", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006941", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "cardiac muscle cell development", "id": "GO:0055013", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055013", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "nerve development", "id": "GO:0021675", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021675", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "water transport", "id": "GO:0006833", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006833", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "response to light stimulus", "id": "GO:0009416", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009416", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "long-term synaptic potentiation", "id": "GO:0060291", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060291", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "glycoprotein metabolic process", "id": "GO:0009100", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009100", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "protein O-linked mannosylation", "id": "GO:0035269", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035269", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "neuromuscular process controlling posture", "id": "GO:0050884", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050884", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "principal sensory nucleus of trigeminal nerve development", "id": "GO:0021740", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021740", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "connective tissue development", "id": "GO:0061448", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061448", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "striated muscle cell development", "id": "GO:0055002", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055002", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "walking behavior", "id": "GO:0090659", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090659", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "determination of adult lifespan", "id": "GO:0008340", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008340", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "myotube differentiation", "id": "GO:0014902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014902", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "gene expression", "id": "GO:0010467", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010467", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "potassium ion transmembrane transport", "id": "GO:0071805", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071805", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "dentate gyrus development", "id": "GO:0021542", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021542", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "macrophage differentiation", "id": "GO:0030225", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030225", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "basement membrane organization", "id": "GO:0071711", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071711", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "skeletal muscle fiber differentiation", "id": "GO:0098528", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098528", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "protein-containing complex assembly", "id": "GO:0065003", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0065003", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "reactive gliosis", "id": "GO:0150103", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0150103", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "post-embryonic hindlimb morphogenesis", "id": "GO:0035129", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035129", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "localization of cell", "id": "GO:0051674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051674", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "xylosyltransferase activity", "id": "GO:0042285", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042285", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "manganese ion binding", "id": "GO:0030145", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030145", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "glycosyltransferase activity", "id": "GO:0016757", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016757", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "glucuronosyltransferase activity", "id": "GO:0015020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015020", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "hexosyltransferase activity", "id": "GO:0016758", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016758", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "neuromuscular junction", "id": "GO:0031594", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031594", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "intracellular membrane-bounded organelle", "id": "GO:0043231", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043231", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K618", "url": "https://www.uniprot.org/uniprot/A0A0G2K618" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 122, "end_pos": 124, "annotation": "n_glycosylation_sequon" }, { "start_pos": 148, "end_pos": 150, "annotation": "n_glycosylation_sequon" }, { "start_pos": 271, "end_pos": 273, "annotation": "n_glycosylation_sequon" }, { "start_pos": 753, "end_pos": 755, "annotation": "n_glycosylation_sequon" }, { "start_pos": 97, "end_pos": 99, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "57336", "name": "", "equation": "3-O-[beta-D-GlcA-(1->3)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP-alpha-D-xylose = 3-O-[alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + H(+) + UDP", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q6P7A1-1" ], "evidence": [ { "id": "57336", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/57336" } ] }, { "id": "67924", "name": "", "equation": "3-O-{(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + UDP-alpha-D-glucuronate = 3-O-{beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + H(+) + UDP", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q6P7A1-1" ], "evidence": [ { "id": "67924", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/67924" } ] }, { "id": "68368", "name": "", "equation": "3-O-{beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + UDP-alpha-D-xylose = 3-O-{(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n+1)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + H(+) + UDP", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q6P7A1-1" ], "evidence": [ { "id": "68368", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/68368" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "Q6P7A1", "gene_name": "Large2", "activity": [ { "ec_number": "2.4.2.-", "activity": "", "evidence": [ { "id": "Q6P7A1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P7A1" } ] }, { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "Q6P7A1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P7A1" } ] }, { "ec_number": "2.4.-.-", "activity": "", "evidence": [ { "id": "Q6P7A1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P7A1" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A0G2K618-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 755, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A0G2K618-F1.pdb" } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 122, "end_pos": 124 }, { "start_pos": 148, "end_pos": 150 }, { "start_pos": 271, "end_pos": 273 }, { "start_pos": 753, "end_pos": 755 }, { "start_pos": 97, "end_pos": 99 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }