{ "uniprot_canonical_ac": "A0A0G2K5L2-1", "uniprot_ac": "A0A0G2K5L2", "uniprot_id": "GHC1_RAT", "mass": { "chemical_mass": 34662.0, "monoisotopic_mass": 34662.0 }, "refseq": { "ac": "NP_001014049", "name": "mitochondrial glutamate carrier 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014049" }, "gene_names": [ { "name": "Slc25a22", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A0G2K5L2", "id": "A0A0G2K5L2" }, { "name": "GC-1; GC1; RGD1307826", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014049", "id": "NP_001014049" }, { "name": "Gc1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A0G2K5L2", "id": "A0A0G2K5L2" }, { "name": "Slc25a22", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014049", "id": "NP_001014049" } ], "protein_names": [ { "name": "Mitochondrial glutamate carrier 1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K5L2/entry#names_and_taxonomy", "id": "A0A0G2K5L2" }, { "name": "GC-1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K5L2/entry#names_and_taxonomy", "id": "A0A0G2K5L2" }, { "name": "Glutamate/H(+) symporter 1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K5L2/entry#names_and_taxonomy", "id": "A0A0G2K5L2" }, { "name": "Solute carrier family 25 member 22", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K5L2/entry#names_and_taxonomy", "id": "A0A0G2K5L2" }, { "name": "mitochondrial glutamate carrier 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014049", "id": "NP_001014049" }, { "name": "solute carrier family 25 (mitochondrial carrier, glutamate), member 22; mitochondrial glutamate carrier 1-like; glutamate/H(+) symporter 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014049", "id": "NP_001014049" } ], "function": [ { "annotation": "Insulin-secreting cells depend on GC1 for maximal glucose response.", "evidence": [ { "database": "RefSeq", "id": "NP_001014049", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014049" }, { "database": "PubMed", "id": "19584051", "url": "https://glygen.org/publication/PubMed/19584051" } ] }, { "annotation": "Mitochondrial glutamate/H(+) symporter (By similarity). Responsible for the transport of glutamate from the cytosol into the mitochondrial matrix with the concomitant import of a proton (Probable). Plays a role in the control of glucose-stimulated insulin secretion (PubMed:19584051).", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K5L2", "url": "https://www.uniprot.org/uniprot/A0A0G2K5L2#function" }, { "database": "UniProtKB", "id": "Q9H936", "url": "https://www.uniprot.org/uniprot/Q9H936#function" }, { "database": "PubMed", "id": "19584051", "url": "https://glygen.org/publication/PubMed/19584051" } ] } ], "disease": [ { "disease_id": "DOID:0080440", "recommended_name": { "id": "DOID:0080440", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080440", "name": "developmental and epileptic encephalopathy 3", "description": "A developmental and epileptic encephalopathy characterized by onset in the first months of life of erratic, typically myoclonic, refractory seizures that has_material_basis_in homozygous or compound heterozygous mutation in the SLC25A22 gene on chromosome 11p15." }, "synonyms": [ { "id": "DOID:0080440", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080440", "name": "early infantile epileptic encephalopathy 3", "description": "" }, { "id": "MONDO:0012245", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012245", "name": "developmental and epileptic encephalopathy, 3", "description": "Any early infantile epileptic encephalopathy in which the cause of the disease is a mutation in the SLC25A22 gene." }, { "id": "MONDO:0012245", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012245", "name": "DEE3", "description": "" }, { "id": "MONDO:0012245", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012245", "name": "EIEE3", "description": "" }, { "id": "MONDO:0012245", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012245", "name": "SLC25A22 early infantile epileptic encephalopathy", "description": "" }, { "id": "MONDO:0012245", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012245", "name": "developmental and epileptic encephalopathy 3", "description": "" }, { "id": "MONDO:0012245", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012245", "name": "early infantile epileptic encephalopathy caused by mutation in SLC25A22", "description": "" }, { "id": "MONDO:0012245", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012245", "name": "epileptic encephalopathy, early infantile, 3", "description": "" }, { "id": "MONDO:0012245", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012245", "name": "epileptic encephalopathy, early infantile, type 3", "description": "" }, { "id": "MIM:609304", "resource": "MIM", "url": "https://www.omim.org/entry/609304", "name": "Developmental and epileptic encephalopathy 3", "description": "Developmental and epileptic encephalopathy 3" } ], "evidence": [ { "id": "0080440", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0080440" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K5L2", "url": "https://www.uniprot.org/uniprot/A0A0G2K5L2" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "gene": [ { "name": "Slc25a22", "url": "https://www.uniprot.org/uniprot/A0A0G2K5L2", "locus": { "chromosome": "1", "start_pos": 196528472, "end_pos": 196536331, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000049944", "url": "https://www.ensembl.org/id/ENSRNOG00000049944" } ] } } ], "crossref": [ { "id": "A0A0G2K5L2", "url": "https://alphafold.ebi.ac.uk/entry/A0A0G2K5L2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSRNOG00000018450", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000018450", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "309111", "url": "https://www.ncbi.nlm.nih.gov/gene/309111", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "A0A0G2K5L2", "url": "https://www.ebi.ac.uk/intact/interactors/id:A0A0G2K5L2*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR002067", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002067", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018108", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018108", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023395", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023395", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051028", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051028", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:309111", "url": "https://www.genome.jp/dbget-bin/www_bget?rno:309111", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KIWQHEG", "url": "https://omabrowser.org/oma/group/KIWQHEG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A0G2K5L2", "url": "https://www.orthodb.org/?gene=A0A0G2K5L2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45678", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45678", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45678:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45678:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00153", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00153", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_A0A0G2K5L2", "url": "http://purl.obolibrary.org/obo/PR_A0A0G2K5L2", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-RNO-428643", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-428643", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-9856872", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9856872", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001014049", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014049", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "1307826", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1307826", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "70955", "url": "https://www.rhea-db.org/rhea/70955", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A0G2JTG5", "url": "https://www.uniprot.org/uniprot/A0A0G2JTG5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2JTG5-1", "url": "https://www.uniprot.org/uniprot/A0A0G2JTG5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2K5L2", "url": "https://www.uniprot.org/uniprot/A0A0G2K5L2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2K5L2-1", "url": "https://www.uniprot.org/uniprot/A0A0G2K5L2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2K5L2-2", "url": "https://www.uniprot.org/uniprot/A0A0G2K5L2-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6AAT8", "url": "https://www.uniprot.org/uniprot/A0A8I6AAT8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6AAT8-1", "url": "https://www.uniprot.org/uniprot/A0A8I6AAT8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MADKQISLPAKLINGGIAGLIGVTCVFPIDLAKTRLQNQQNGQRMYASMSDCLIKTIRSEGYFGMYRGAAVNLTLVTPEKAIKLAANDFFRHQLSKDGQKLTLPKEMLAGCGAGTCQVIVTTPMEMLKIQLQDAGRIAAQRKMLAAQAQLATQGGGQPSVEAPAAPRPTATQLTRDLLRNHGIAGLYKGLGATLLRDVPFSIVYFPLFANLNQLGRPSSEEKSPFYVSFLAGCVAGSAAAVAVNPCDVVKTRLQSLERGVNEDTYSGFLDCARKIWRHEGPSAFLKGAYCRALVIAPLFGIAQVVYFLGIAESLLGLLQEPQA", "length": 323, "header": "sp|A0A0G2K5L2-1|GHC1_RAT Isoform 1 of Mitochondrial glutamate carrier 1 OS=Rattus norvegicus OX=10116 GN=Slc25a22 PE=2 SV=1 CANONICAL=A0A0G2K5L2-1" }, "isoforms": [ { "isoform_ac": "A0A0G2JTG5-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K5L2/entry#A0A0G2JTG5-1", "sequence": { "sequence": "MADKQISLPAKLINGGIAGLIGVTCVFPIDLAKTRLQNQQNGQRMYASMSDCLIKTIRSEGYFGMYRAAVNLTLVTPEKAIKLAANDFFRHQLSKDGQKLTLPKEMLAGCGAGTCQVIVTTPMEMLKIQLQDAGRIAAQRKMLAAQAQLATQGGGQPSVEAPAAPRPTATQLTRDLLRNHGIAGLYKGLGATLLRDVPFSIVYFPLFANLNQLGRPSSEEKSPFYVSFLAGCVAGSAAAVAVNPCDVVKTRLQSLERGVNEDTYSGFLDCARKIWRHEGPSAFLKGAYCRALVIAPLFGIAQVVYFLGIAESLLGLLQEPQA", "length": 322, "header": "tr|A0A0G2JTG5-1|A0A0G2JTG5_RAT Computationally mapped isoform of Mitochondrial glutamate carrier 1 OS=Rattus norvegicus OX=10116 GN=Slc25a22 PE=1 SV=1 CANONICAL=A0A0G2K5L2-1" }, "locus": { "chromosome": "1", "start_pos": 196532846, "end_pos": 196529823, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000077776.2", "url": "https://www.ensembl.org/id/ENSRNOT00000077776.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000068705.2", "url": "https://www.ensembl.org/id/ENSRNOP00000068705.2" } ] } }, { "isoform_ac": "A0A0G2K5L2-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K5L2/entry#A0A0G2K5L2-1", "sequence": { "sequence": "MADKQISLPAKLINGGIAGLIGVTCVFPIDLAKTRLQNQQNGQRMYASMSDCLIKTIRSEGYFGMYRGAAVNLTLVTPEKAIKLAANDFFRHQLSKDGQKLTLPKEMLAGCGAGTCQVIVTTPMEMLKIQLQDAGRIAAQRKMLAAQAQLATQGGGQPSVEAPAAPRPTATQLTRDLLRNHGIAGLYKGLGATLLRDVPFSIVYFPLFANLNQLGRPSSEEKSPFYVSFLAGCVAGSAAAVAVNPCDVVKTRLQSLERGVNEDTYSGFLDCARKIWRHEGPSAFLKGAYCRALVIAPLFGIAQVVYFLGIAESLLGLLQEPQA", "length": 323, "header": "sp|A0A0G2K5L2-1|GHC1_RAT Isoform 1 of Mitochondrial glutamate carrier 1 OS=Rattus norvegicus OX=10116 GN=Slc25a22 PE=2 SV=1 CANONICAL=A0A0G2K5L2-1" }, "locus": { "chromosome": "1", "start_pos": 196532846, "end_pos": 196529823, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000086238.2", "url": "https://www.ensembl.org/id/ENSRNOT00000086238.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000073467.1", "url": "https://www.ensembl.org/id/ENSRNOP00000073467.1" } ] } }, { "isoform_ac": "A0A0G2K5L2-2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K5L2/entry#A0A0G2K5L2-2", "sequence": { "sequence": "MADKQISLPAKLINGGIAGLIGVTCVFPIDLAKTRLQNQQNGQRMYASMSDCLIKTIRSEGYFGMYRGAAVNLTLVTPEKAIKLAANDFFRHQLSKDGQKLTLPKEMLAGCGAGTCQVIVTTPMEMLKIQLQDAGRIGCVAGSAAAVAVNPCDVVKTRLQSLERGVNEDTYSGFLDCARKIWRHEGPSAFLKGAYCRALVIAPLFGIAQVVYFLGIAESLLGLLQEPQA", "length": 229, "header": "sp|A0A0G2K5L2-2|GHC1_RAT Isoform 2 of Mitochondrial glutamate carrier 1 OS=Rattus norvegicus OX=10116 GN=Slc25a22 PE=2 SV=1 CANONICAL=A0A0G2K5L2-1" }, "locus": { "chromosome": "1", "start_pos": 196532846, "end_pos": 196529823, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000054869.5", "url": "https://www.ensembl.org/id/ENSRNOT00000054869.5" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000051753.2", "url": "https://www.ensembl.org/id/ENSRNOP00000051753.2" } ] } }, { "isoform_ac": "A0A8I6AAT8-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K5L2/entry#A0A8I6AAT8-1", "sequence": { "sequence": "MADKQISLPAKLINGGIAGLIGVTCVFPIDLAKTRLQNQQNGQRMYASMSDCLIKTIRSEGYFGMYRGEAWGWATDGSGWEQGQGCMPRLGL", "length": 92, "header": "tr|A0A8I6AAT8-1|GHC1_RAT Computationally mapped isoform of Mitochondrial glutamate carrier 1 OS=Rattus norvegicus OX=10116 GN=Slc25a22 PE=2 SV=1 CANONICAL=A0A0G2K5L2-1" }, "locus": { "chromosome": "1", "start_pos": 196532846, "end_pos": 196532198, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000112082.1", "url": "https://www.ensembl.org/id/ENSRNOT00000112082.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000088989.1", "url": "https://www.ensembl.org/id/ENSRNOP00000088989.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Mitochondrial glutamate carrier GC1 as a newly identified player in the control of glucose-stimulated insulin secretion.", "journal": "The Journal of biological chemistry", "date": "2009", "authors": "Casimir M, Lasorsa FM, Rubi B, Caille D, Palmieri F, Meda P, Maechler P", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K5L2", "url": "https://www.uniprot.org/uniprot/A0A0G2K5L2" }, { "database": "RefSeq", "id": "NP_001014049", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014049" } ], "reference": [ { "type": "PubMed", "id": "19584051", "url": "https://glygen.org/publication/PubMed/19584051" } ] } ], "pathway": [ { "id": "rno:309111", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?rno:309111", "resource": "KEGG Pathway" }, { "id": "R-RNO-428643", "name": "Organic anion transporters", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-428643", "resource": "Reactome", "description": "Organic anion transporters" }, { "id": "R-RNO-9856872", "name": "Malate-aspartate shuttle", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9856872", "resource": "Reactome", "description": "Malate-aspartate shuttle" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0ZTQ5-1", "protein_name": "Mitochondrial glutamate carrier 1", "gene_name": "SLC25A22", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MADKQISLPAKLINGGIAGLIGVTCVFPIDLAKTRLQNQQNGQRMYTSMSDCLIKTIRSEGYFGMYRGAAVNLTLVTPEKAIKLAANDFFRHHLSKDGKKLTLLREMLAGCGAGTCQVIVTTPMEMLKIQLQDAGRIAAQKKLMAAQAQLSPSSAAGAAEPVVEARTTATQITRELLRSKGIAGLYKGLGATLLRDVPFSIVYFPLFANLNKLGQKDPDVKAPFYVSFLSGCVAGSTAAVAVNPCDVIKTRLQSLQRGVNEDTYSGILDCTKTHGLPERGVLPSPGHRSSLRHRTSRLLHWHCGVPPGHTPQAPGLAPACLPVPARPLPHRIHPCVCRPCPVVSEQQHRGFAWEHGGHGLQTSKRGKGESLFCLDLEPVPSLSFHGQYPIMHTFFFFFYPFLFFFFFFSFFFLIIILKDTGKHRLGLHTQKSPPSIYKEEGRGKK", "length": 445 }, "evidence": [ { "id": "A0A0G2K5L2", "url": "https://omabrowser.org/oma/group/A0A0G2K5L2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1RYY8-1", "protein_name": "Mitochondrial glutamate carrier 1", "gene_name": "SLC25A22", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAEKQISLPAKLINGGIAGLIGVTCVFPIDLAKTRLQNQQNGQRMYTSMSDCLIKTIRSEGYFGMYRGAAVNLTLVTPEKAIKLAANDFFRHQLSKDGQKLTLLKEMLAGCGAGTCQVIVTTPMEMLKIQLQDAGRIAAQKKILAAHARLSAQGAAQPSVEAPATPRPTATQLTRDLLRSRGIAGLYKGLGATLLRDVPFSIVYFPLFANLDQLGRPASGEKSPFYVSFLAGCVAGSAAAVAVNPCDVVKTRLQSLQRGANEDTYSGILDCARKILRHEGPSAFLKGAYCRALVIAPLFGIAQVVYFLGIAETLLGLQRSQP", "length": 322 }, "evidence": [ { "id": "A0A0G2K5L2", "url": "https://omabrowser.org/oma/group/A0A0G2K5L2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F4HT41-1", "protein_name": "Probable S-adenosylmethionine carrier 2, chloroplastic", "gene_name": "SAMC2", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MTKALSGFCCSLSLSTLVRSSSSHMDSDIVSSSIDRSQTAMPDALAFKSINDPIKNQINSCAAICVKQDDPCHFLRVLYESLITGGLAGVVVEAALYPIDTIKTRIQVARDGGKIIWKGLYSGLGGNLVGVLPASALFFGVYEPTKQKLLKVLPDNLSAVAHLAAGALGGAVSSIVRVPTEVVKQRMQTGQFVSAPDAVRLIIAKEGFGGMYAGYGSFLLRDLPFDALQFCVYEQLRIGYKLAARRDLNDPENAMIGAFAGAVTGVLTTPLDVIKTRLMVQGSGTQYKGVSDCIKTIIREEGSSALWKGMGPRVLWIGIGGSIFFGVLEKTKQILSERSQKSHNA", "length": 345 }, "evidence": [ { "id": "A0A0G2K5L2", "url": "https://omabrowser.org/oma/group/A0A0G2K5L2/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q08DK4-1", "protein_name": "Mitochondrial glutamate carrier 1", "gene_name": "SLC25A22", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MADKQISLPAKLINGGIAGLIGVTCVFPIDLAKTRLQNQQNGQRMYTSMSDCLIKTIRSEGYFGMYRGAAVNLTLVTPEKAIKLAANDFFRYQLSKDGQQLTLFKEMLAGCGAGTCQVIVTTPMEMLKIQLQDAGRLAAQRKILSAQAQLSGQGSAQPSVEAPATPRPTATQLTRDLLRSRGIAGLYKGLGATLLRDVPFSIVYFPLFANLNELGRPASGEKSPFYVSFLAGCVAGSAAAVAVNPCDVVKTRLQSLQRGINEDTYSGFLDCARKILQNEGPSAFLKGAYCRALVIAPLFGIAQVVYFLGIAETLLGLPRVQP", "length": 322 }, "evidence": [ { "id": "A0A0G2K5L2", "url": "https://omabrowser.org/oma/group/A0A0G2K5L2/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "Q86AV5-1", "protein_name": "Mitochondrial substrate carrier family protein X", "gene_name": "mcfX", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MVQQQQQQQQIKKNQVKPPLYSNLIAGAIAGVIGSSVVFPLDFVKTRLQQQRVSIDGSKQYNGIIDCFKKVIKNEGGVRGLYRGLSSNLIGIIPEKALKLAMNDYFRTRFQGDRSYIKLWEEVASGGLAGMCQVVATNPMELVKIRMQVSGLSGKKASLKEVVSELGIKGLYKGTASTLLRDVPFSMIYFSIYGRMKHNLTDQETGEIGLPKILLCGITAGSIAASVSTPFDVIKTRIQVKPGPNDPHYKGIADCFRKTIQSEGPKALFKGVLPRVCIISPLFGITLVVYEIQKSFYASTH", "length": 301 }, "evidence": [ { "id": "A0A0G2K5L2", "url": "https://omabrowser.org/oma/group/A0A0G2K5L2/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9D6M3-1", "protein_name": "Mitochondrial glutamate carrier 1", "gene_name": "Slc25a22", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MADKQISLPAKLINGGIAGLIGVTCVFPIDLAKTRLQNQQNGQRMYASMSDCLIKTIRSEGYFGMYRGAAVNLTLVTPEKAIKLAANDFFRHQLSKDGQKLTLPKEMLAGCGAGTCQVIVTTPMEMLKIQLQDAGRIAAQRKILAAQAQLSAQGGAQPSVEAPAPPRPTATQLTRDLLRNHGIAGLYKGLGATLLRDVPFSIVYFPLFANLNQLGRPSSEEKSPFYVSFLAGCVAGSAAAVAVNPCDVVKTRLQSLERGVNEDTYSGFLDCARKIWRHEGPSAFLKGAYCRALVIAPLFGIAQVVYFLGIAESLLGLLQEPQA", "length": 323 }, "evidence": [ { "id": "47569466", "url": "http://www.informatics.jax.org/homology/47569466", "database": "MGI" }, { "id": "A0A0G2K5L2", "url": "https://omabrowser.org/oma/group/A0A0G2K5L2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9H936-1", "protein_name": "Mitochondrial glutamate carrier 1", "gene_name": "SLC25A22", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MADKQISLPAKLINGGIAGLIGVTCVFPIDLAKTRLQNQQNGQRVYTSMSDCLIKTVRSEGYFGMYRGAAVNLTLVTPEKAIKLAANDFFRHQLSKDGQKLTLLKEMLAGCGAGTCQVIVTTPMEMLKIQLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAPAAPRPTATQLTRDLLRSRGIAGLYKGLGATLLRDVPFSVVYFPLFANLNQLGRPASEEKSPFYVSFLAGCVAGSAAAVAVNPCDVVKTRLQSLQRGVNEDTYSGILDCARKILRHEGPSAFLKGAYCRALVIAPLFGIAQVVYFLGIAESLLGLLQDPQA", "length": 323 }, "evidence": [ { "id": "47569466", "url": "http://www.informatics.jax.org/homology/47569466", "database": "MGI" }, { "id": "A0A0G2K5L2", "url": "https://omabrowser.org/oma/group/A0A0G2K5L2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K5L2", "url": "https://www.uniprot.org/uniprot/A0A0G2K5L2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "transmembrane transport", "id": "GO:0055085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055085", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K5L2", "url": "https://www.uniprot.org/uniprot/A0A0G2K5L2" } ], "pmid": "" }, { "name": "regulation of insulin secretion", "id": "GO:0050796", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050796", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K5L2", "url": "https://www.uniprot.org/uniprot/A0A0G2K5L2" } ], "pmid": "" }, { "name": "L-glutamate transmembrane transport", "id": "GO:0015813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015813", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K5L2", "url": "https://www.uniprot.org/uniprot/A0A0G2K5L2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "amino acid:proton symporter activity", "id": "GO:0005280", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005280", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K5L2", "url": "https://www.uniprot.org/uniprot/A0A0G2K5L2" } ], "pmid": "" }, { "name": "L-glutamate transmembrane transporter activity", "id": "GO:0005313", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005313", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K5L2", "url": "https://www.uniprot.org/uniprot/A0A0G2K5L2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 72, "end_pos": 74, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "70955", "name": "", "equation": "H(+)(in) + L-glutamate(in) = H(+)(out) + L-glutamate(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "70955", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/70955" } ] } ], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A0G2K5L2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 323, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A0G2K5L2-F1.pdb" } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 72, "end_pos": 74 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], 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