{ "uniprot_canonical_ac": "A0A0G2K583-1", "uniprot_ac": "A0A0G2K583", "uniprot_id": "A0A0G2K583_RAT", "mass": { "chemical_mass": 31089.0, "monoisotopic_mass": 31089.0 }, "refseq": { "ac": "XP_006238444", "name": "S-methyl-5'-thioadenosine phosphorylase", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006238444" }, "gene_names": [ { "name": "Mtap", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A0G2K583", "id": "A0A0G2K583" }, { "name": "Cc1-6", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006238444", "id": "XP_006238444" }, { "name": "MTAP", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A0G2K583", "id": "A0A0G2K583" }, { "name": "Mtap_predicted", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A0G2K583", "id": "A0A0G2K583" }, { "name": "Mtap", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006238444", "id": "XP_006238444" } ], "protein_names": [ { "name": "S-methyl-5'-thioadenosine phosphorylase", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K583/entry#names_and_taxonomy", "id": "A0A0G2K583" }, { "name": "2.4.2.28", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K583/entry#names_and_taxonomy", "id": "A0A0G2K583" }, { "name": "5'-methylthioadenosine phosphorylase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006238444", "id": "XP_006238444" }, { "name": "5'-methylthioadenosine phosphorylase", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K583/entry#names_and_taxonomy", "id": "A0A0G2K583" }, { "name": "MTA phosphorylase", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K583/entry#names_and_taxonomy", "id": "A0A0G2K583" }, { "name": "MTAPase", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K583/entry#names_and_taxonomy", "id": "A0A0G2K583" }, { "name": "MTAP", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K583/entry#names_and_taxonomy", "id": "A0A0G2K583" }, { "name": "S-methyl-5'-thioadenosine phosphorylase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006238444", "id": "XP_006238444" } ], "function": [ { "annotation": "Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZXI1", "url": "https://www.uniprot.org/uniprot/A0A8I5ZXI1#function" }, { "database": "HAMAP", "id": "MF_03155", "url": "https://hamap.expasy.org/signature/MF_03155" }, { "database": "UniProtKB", "id": "Q7TP15", "url": "https://www.uniprot.org/uniprot/Q7TP15#function" }, { "database": "UniProtKB", "id": "A0A0G2K583", "url": "https://www.uniprot.org/uniprot/A0A0G2K583#function" } ] } ], "disease": [ { "disease_id": "DOID:0050625", "recommended_name": { "id": "DOID:0050625", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050625", "name": "biliary tract benign neoplasm", "description": "A hepatobiliary benign neoplasm located_in the biliary tract." }, "synonyms": [ { "id": "DOID:0050625", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050625", "name": "extrahepatic bile duct neoplasm", "description": "" }, { "id": "DOID:0050625", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050625", "name": "neoplasm of extrahepatic bile ducts", "description": "" }, { "id": "DOID:0050625", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050625", "name": "tumor of the extrahepatic bile duct", "description": "" } ], "evidence": [ { "id": "0050625", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0050625" } ] }, { "disease_id": "DOID:0080664", "recommended_name": { "id": "DOID:0080664", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080664", "name": "diaphyseal medullary stenosis with malignant fibrous histiocytoma", "description": "An osteochondrodysplasia that is characterized by pathologic fractures due to abnormal cortical growth and diaphyseal medullary stenosis and that has_material_basis_in heterozygous mutation in the MTAP gene on chromosome 9p21." }, "synonyms": [ { "id": "DOID:0080664", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080664", "name": "Hardcastle syndrome", "description": "" }, { "id": "DOID:0080664", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080664", "name": "diaphyseal medullary stenosis-malignant fibrous histiocytoma syndrome", "description": "" }, { "id": "DOID:0080664", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080664", "name": "bone dysplasia-medullary fibrosarcoma syndrome", "description": "" }, { "id": "MONDO:0007205", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007205", "name": "diaphyseal medullary stenosis-bone malignancy syndrome", "description": "Diaphyseal medullary stenosis with malignant fibrous histiocytoma is a very rare autosomal dominant bone dysplasia/cancer syndrome characterized clinically by bone infarctions, cortical growth abnormalities, pathological fractures, and development of bone sarcoma (malignant fibrous histiocytoma)." }, { "id": "MONDO:0007205", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007205", "name": "DMS-MFH", "description": "" }, { "id": "MONDO:0007205", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007205", "name": "Hardcastle syndrome", "description": "" }, { "id": "MONDO:0007205", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007205", "name": "Hardcastle's syndrome", "description": "" }, { "id": "MONDO:0007205", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007205", "name": "bone dysplasia-medullary fibrosarcoma syndrome", "description": "" }, { "id": "MONDO:0007205", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007205", "name": "diaphyseal medullary stenosis-bone malignancy syndrome", "description": "" }, { "id": "MONDO:0007205", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007205", "name": "diaphyseal medullary stenosis-malignant fibrous histiocytoma syndrome", "description": "" }, { "id": "MONDO:0007205", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007205", "name": "BDMF", "description": "" }, { "id": "MONDO:0007205", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007205", "name": "DMSMFH", "description": "" }, { "id": "MONDO:0007205", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007205", "name": "bone dysplasia with malignant fibrous histiocytoma", "description": "" }, { "id": "MONDO:0007205", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007205", "name": "bone dysplasia with medullary fibrosarcoma", "description": "" }, { "id": "MONDO:0007205", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007205", "name": "diaphyseal medullary stenosis with malignant fibrous histiocytoma", "description": "" }, { "id": "MONDO:0007205", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007205", "name": "myopathy, limb-girdle, with bone fragility", "description": "" }, { "id": "MIM:112250", "resource": "MIM", "url": "https://www.omim.org/entry/112250", "name": "Diaphyseal medullary stenosis with malignant fibrous histiocytoma", "description": "Diaphyseal medullary stenosis with malignant fibrous histiocytoma" } ], "evidence": [ { "id": "0080664", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0080664" } ] }, { "disease_id": "DOID:1793", "recommended_name": { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreatic cancer", "description": "An endocrine gland cancer located_in the pancreas." }, "synonyms": [ { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "Ca body of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "Ca head of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "Ca tail of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of body of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of head of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of tail of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreas neoplasm", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreatic neoplasm", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreatic tumor", "description": "" } ], "evidence": [ { "id": "1793", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1793" } ] }, { "disease_id": "DOID:4608", "recommended_name": { "id": "DOID:4608", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4608", "name": "common bile duct neoplasm", "description": "" }, "synonyms": [ { "id": "DOID:4608", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4608", "name": "neoplasm of common bile duct", "description": "" } ], "evidence": [ { "id": "4608", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:4608" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K583", "url": "https://www.uniprot.org/uniprot/A0A0G2K583" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "gene": [ { "name": "Mtap", "url": "https://www.uniprot.org/uniprot/A0A0G2K583", "locus": { "chromosome": "5", "start_pos": 103939406, "end_pos": 103873020, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000006615", "url": "https://www.ensembl.org/id/ENSRNOG00000006615" } ] } } ], "crossref": [ { "id": "A0A0G2K583", "url": "https://alphafold.ebi.ac.uk/entry/A0A0G2K583", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSRNOG00000006615", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000006615", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd09010", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09010", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000845", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000845", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010044", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010044", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018099", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018099", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035994", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035994", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "ADPFCPE", "url": "https://omabrowser.org/oma/group/ADPFCPE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A0G2K583", "url": "https://www.orthodb.org/?gene=A0A0G2K583", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q7TP15", "url": "https://www.orthodb.org/?gene=Q7TP15", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR42679", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42679", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR42679:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42679:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01048", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01048", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-1237112", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1237112", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "XP_006238444", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006238444", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "1310114", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1310114", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "11852", "url": "https://www.rhea-db.org/rhea/11852", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A0G2K583", "url": "https://www.uniprot.org/uniprot/A0A0G2K583", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2K583-1", "url": "https://www.uniprot.org/uniprot/A0A0G2K583-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5ZXI1", "url": "https://www.uniprot.org/uniprot/A0A8I5ZXI1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5ZXI1-1", "url": "https://www.uniprot.org/uniprot/A0A8I5ZXI1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q7TP15", "url": "https://www.uniprot.org/uniprot/Q7TP15", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q7TP15-1", "url": "https://www.uniprot.org/uniprot/Q7TP15-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASGSACTAVKIGIIGGTGLDDPEILEGRTEKYVDTPFGKPSDALILGKIKNVDCVLLARHGRHHTIMPSKVNYQANIWALKEEGCTHVIVTTACGSLREEIQPGDMVIIDQFIDRTSLRPQTFYDGSHCSARGVCHIPMAEPFCPKTREVLIEMAKKLGLRCHSKGTIVTIEGPRFSSRAESFIFRTWGADVINMTTVPEVVLAKEAGLCYASIAMATDYDCWKEHEEAVSVDGVLKTMKENANKAKSLLLTTIPQIGSMEWSETLRNLKNMAQSSVLPPRH", "length": 283, "header": "tr|A0A0G2K583-1|A0A0G2K583_RAT Isoform 1 of S-methyl-5'-thioadenosine phosphorylase OS=Rattus norvegicus OX=10116 GN=Mtap PE=1 SV=1 CANONICAL=A0A0G2K583-1" }, "isoforms": [ { "isoform_ac": "A0A0G2K583-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K583/entry#A0A0G2K583-1", "sequence": { "sequence": "MASGSACTAVKIGIIGGTGLDDPEILEGRTEKYVDTPFGKPSDALILGKIKNVDCVLLARHGRHHTIMPSKVNYQANIWALKEEGCTHVIVTTACGSLREEIQPGDMVIIDQFIDRTSLRPQTFYDGSHCSARGVCHIPMAEPFCPKTREVLIEMAKKLGLRCHSKGTIVTIEGPRFSSRAESFIFRTWGADVINMTTVPEVVLAKEAGLCYASIAMATDYDCWKEHEEAVSVDGVLKTMKENANKAKSLLLTTIPQIGSMEWSETLRNLKNMAQSSVLPPRH", "length": 283, "header": "tr|A0A0G2K583-1|A0A0G2K583_RAT Isoform 1 of S-methyl-5'-thioadenosine phosphorylase OS=Rattus norvegicus OX=10116 GN=Mtap PE=1 SV=1 CANONICAL=A0A0G2K583-1" }, "locus": { "chromosome": "5", "start_pos": 103916857, "end_pos": 103874619, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000090739.2", "url": "https://www.ensembl.org/id/ENSRNOT00000090739.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000073330.1", "url": "https://www.ensembl.org/id/ENSRNOP00000073330.1" } ] } }, { "isoform_ac": "A0A8I5ZXI1-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K583/entry#A0A8I5ZXI1-1", "sequence": { "sequence": "WEPTGPCTAHSRAVPAPQSPLGPALRPAVDFPGADMASGSACTAVKIGIIGGTGLDDPEILEGRTEKYVDTPFGKPSDALILGKIKNVDCVLLASMYVLDRMCEFLLLPFCVQLNSLHEIPPGSSCHTSYLFAFVARWERRVRWLARVLCERAFVPSSASTSVQWKETKHSKEITQRSKASRFSTTVQQQAIREECQTSLRPQTFYDGSHCSARGVCHIPMAEPFCPKTREVLIEMAKKLGLRCHSKGTIVTIEGPRFSSRAESFIFRTWGADVINMTTVPEVVLAKEAGLCYASIAMATDYDCWKEHEEAVSVDGVLKTMKENANKAKSLLLTTIPQIGSMEWSETLRNLKVSVLMSKISIYQTLN", "length": 367, "header": "tr|A0A8I5ZXI1-1|A0A8I5ZXI1_RAT Computationally mapped isoform of S-methyl-5'-thioadenosine phosphorylase OS=Rattus norvegicus OX=10116 GN=Mtap PE=1 SV=1 CANONICAL=A0A0G2K583-1" }, "locus": { "chromosome": "5", "start_pos": 103914800, "end_pos": 103873732, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000096850.1", "url": "https://www.ensembl.org/id/ENSRNOT00000096850.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000082661.1", "url": "https://www.ensembl.org/id/ENSRNOP00000082661.1" } ] } }, { "isoform_ac": "Q7TP15-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K583/entry#Q7TP15-1", "sequence": { "sequence": "MEVGGRCWLILLALGLIAPQSPLGPALRPAVDFPGADMASGSACTAVKIGIIGGTGLDDPEILEGRTEKYVDTPFGKPSDALILGKIKNVDCVLLASMYVLDRMCEFLLLPFCVQLNSLHEIPPGSSCHTSYLFAFVARWERRVRWLARVLCERAFVPSSASTSVQWKETKHSKEITQRSKASRFSTTVQQQAIREECQTSLRPQTFYDGSHCSARGVCHIPMAEPFCPKTREVLIEMAKKLGLRCHSKGTIVTIEGPRFSSRAESFIFRTWGADVINMTTVPEVVLAKEAGLCYASIAMATDYDCWKEHEEAVSVDGVLKTMKENANKAKSLLLTTIPQIGSMEWSETLRNLKVVAVKLYGEKKRELHQKSSGGMLQMLASSKDSGQLAE", "length": 391, "header": "tr|Q7TP15-1|Q7TP15_RAT Computationally mapped isoform of S-methyl-5'-thioadenosine phosphorylase OS=Rattus norvegicus OX=10116 GN=Mtap PE=1 SV=1 CANONICAL=A0A0G2K583-1" }, "locus": { "chromosome": "5", "start_pos": 103939403, "end_pos": 103873020, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000029486.4", "url": "https://www.ensembl.org/id/ENSRNOT00000029486.4" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000031214.2", "url": "https://www.ensembl.org/id/ENSRNOP00000031214.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-RNO-1237112", "name": "Methionine salvage pathway", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1237112", "resource": "Reactome", "description": "Methionine salvage pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0X6U4-1", "protein_name": "S-methyl-5'-thioadenosine phosphorylase", "gene_name": "MTAP", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MTGSHYIWWERGREMQQSGTWREIGIIGGTGLDDPDILEERTEKYVDTPYGKPSDALILGKIKNVDCVLLARHGRHHTIMPSNVNYRANIWALKEENCSHVLVTTACGSLREEIQPGDLVIIDQFIDRTTKRHCTLYDGQSCSLSGVCHIPMSEPFCTKTREVLIEIAKKLGLQCHSKGTMITIEGPRFSSRAESLMFRSWGADVINMTTVPEVILAKEAGMSYASIAMATDYDCWKEHEEAVSVDKVLKTLKENANKATSILLTAIPQIGSMEWTDTLHTLKTTVQCSVILPKQ", "length": 295 }, "evidence": [ { "id": "A0A0G2K583", "url": "https://omabrowser.org/oma/group/A0A0G2K583/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q07938-1", "protein_name": "S-methyl-5'-thioadenosine phosphorylase", "gene_name": "MEU1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MNRIKNTFSVAKRLKLSKVMTNSELPSIFEGTVDLGIIGGTGLYNLDCLEPIALLPPMVTPWGTTSSPVTISQFVGTNSHFHVAFIARHGINHEYPPTKVPFRANMAALKNLNCKAVLSFSAVGSLQPHIKPRDFVLPQQIIDRTKGIRHSSYFNDEGLVGHVGFGQPFSQKFAEYIYQFKNEITNPESEEPCHLHYDKDMTVVCMEGPQFSTRAESKMYRMFGGHVINMSVIPEAKLARECELPYQMICMSTDYDAWRDEAEPVTVETVIGNLTNNGRNANILASKIIVSMAKEIPEFMHTGDGLRGSIKKSISTKPEAMSKETLERLRYLFPNYW", "length": 337 }, "evidence": [ { "id": "A0A0G2K583", "url": "https://omabrowser.org/oma/group/A0A0G2K583/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q13126-1", "protein_name": "S-methyl-5'-thioadenosine phosphorylase", "gene_name": "MTAP", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASGTTTTAVKIGIIGGTGLDDPEILEGRTEKYVDTPFGKPSDALILGKIKNVDCVLLARHGRQHTIMPSKVNYQANIWALKEEGCTHVIVTTACGSLREEIQPGDIVIIDQFIDRTTMRPQSFYDGSHSCARGVCHIPMAEPFCPKTREVLIETAKKLGLRCHSKGTMVTIEGPRFSSRAESFMFRTWGADVINMTTVPEVVLAKEAGICYASIAMATDYDCWKEHEEAVSVDRVLKTLKENANKAKSLLLTTIPQIGSTEWSETLHNLKNMAQFSVLLPRH", "length": 283 }, "evidence": [ { "id": "A0A0G2K583", "url": "https://omabrowser.org/oma/group/A0A0G2K583/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q3MHF7-1", "protein_name": "S-methyl-5'-thioadenosine phosphorylase", "gene_name": "MTAP", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MSSGATPAAVKIGIIGGTGLDDPEILEGRTEKYVDTPFGKPSDALVLGKIKNVDCVLLARHGRQHTIMPSKVNYQANIWALKEEGCTHVIVTTACGSLKEEIQPGDIIIIDQFIDRTTRRLQTFYDGNHSCARGVCHIPMAEPFCPKTREVLIETAKKLGLRCHSKGTMITIEGPRFSSRAESIMFQTWGADVINMTTVPEVVLAKEAGICYASIAMATDYDCWKEHEEAVSVDRVLKTLKENANKAKSLLLTTIPQIGSMEWSETLHNMKKMAQFSVLLPRH", "length": 283 }, "evidence": [ { "id": "A0A0G2K583", "url": "https://omabrowser.org/oma/group/A0A0G2K583/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "Q9CQ65-1", "protein_name": "S-methyl-5'-thioadenosine phosphorylase", "gene_name": "Mtap", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASGSACTAVKIGIIGGTGLDDPEILEGRTEKYVDTPFGKPSDALILGKIKNVDCVLLARHGRQHTIMPSKVNYQANIWALKEEGCTHVIVTTACGSLREEIQPGDMVIIDQFIDRTSLRPQTFYDGSHCSARGVCHIPMAEPFCPKTREVLIETAKKLGLRCHSKGTIVTIEGPRFSSRAESLIFRTWGADVVNMTTVPEVVLAKEAGICYASIAMATDYDCWKEHEEAVSVDGVLKTMKENANKAKSLLLTTIPQIGSMEWSETLRNLKNMAQFSVLPPRH", "length": 283 }, "evidence": [ { "id": "A0A0G2K583", "url": "https://omabrowser.org/oma/group/A0A0G2K583/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9V813-1", "protein_name": "S-methyl-5'-thioadenosine phosphorylase", "gene_name": "Mtap", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MITIKCKDTNLDPLPVKIGIIGGSGLDDPDILEQRQERVVETPYGEPSDALIEGEINGVQCVLLARHGRKHDIMPSNVNYRANIWALRDVGCTHLIVSTACGSLREEIKPGNLVVPHDFIDRTTKRLQTFYDGKAQSPRGVCHLPMFPAFSERTRNILLQAAKELEIPAHDKATIVTIEGPRFSSRSESHMFRQWGGDLINMTTCPEVVLAKEAGLLYGSVAIATDYDCWRMGCEGVNVQDVLRTFAENVIKVKKILVNAVGRIAKEDWSEDILNAKQCVCNNTMSGAM", "length": 289 }, "evidence": [ { "id": "A0A0G2K583", "url": "https://omabrowser.org/oma/group/A0A0G2K583/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K583", "url": "https://www.uniprot.org/uniprot/A0A0G2K583" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K583", "url": "https://www.uniprot.org/uniprot/A0A0G2K583" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K583", "url": "https://www.uniprot.org/uniprot/A0A0G2K583" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "purine ribonucleoside salvage", "id": "GO:0006166", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006166", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K583", "url": "https://www.uniprot.org/uniprot/A0A0G2K583" } ], "pmid": "" }, { "name": "methylation", "id": "GO:0032259", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032259", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K583", "url": "https://www.uniprot.org/uniprot/A0A0G2K583" } ], "pmid": "" }, { "name": "L-methionine salvage from methylthioadenosine", "id": "GO:0019509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019509", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K583", "url": "https://www.uniprot.org/uniprot/A0A0G2K583" } ], "pmid": "" }, { "name": "response to testosterone", "id": "GO:0033574", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033574", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K583", "url": "https://www.uniprot.org/uniprot/A0A0G2K583" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "S-methyl-5-thioadenosine phosphorylase activity", "id": "GO:0017061", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017061", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K583", "url": "https://www.uniprot.org/uniprot/A0A0G2K583" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 195, "end_pos": 197, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "11852", "name": "", "equation": "phosphate + S-methyl-5'-thioadenosine = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A0G2K583-1" ], "evidence": [ { "id": "11852", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/11852" } ] }, { "id": "R-RNO-1237160", "name": "MTA is cleaved and phosphorylated", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [ "R-ALL-1237165", "R-ALL-83951" ], "enzyme_list": [ "A0A0G2K583-1" ], "evidence": [ { "id": "R-RNO-1237160", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1237160" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-1237165", "participant_name": "MTRIBP [cytosol]", "crossref": [ { "id": "58533", "database": "ChEBI", "url": "" }, { "id": "000030725173", "database": "ZINC", "url": "" } ] }, { "participant_id": "R-ALL-83951", "participant_name": "Ade [cytosol]", "crossref": [ { "id": "C00147", "database": "COMPOUND", "url": "" }, { "id": "16708", "database": "ChEBI", "url": "" }, { "id": "000000000882", "database": "ZINC", "url": "" }, { "id": "4788", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "8144939", "database": "PubChem Substance", "url": "" }, { "id": "HMDB0000034", "database": "HMDB Metabolite", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A0G2K583", "gene_name": "Mtap", "activity": [ { "ec_number": "2.4.2.28", "activity": "phosphate + S-methyl-5'-thioadenosine = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate.", "evidence": [ { "id": "A0A0G2K583", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K583" } ] }, { "ec_number": "2.4.2.28", "activity": "", "evidence": [ { "id": "A0A0G2K583", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K583" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A0G2K583-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 283, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A0G2K583-F1.pdb" } ], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.4.2.28", "ec_name": "phosphate + S-methyl-5'-thioadenosine = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate.", "evidence": [ { "id": "2.4.2.28", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.28" }, { "id": "2.4.2.28", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.4.2.28" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 195, "end_pos": 197 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }