{ "uniprot_canonical_ac": "A0A0G2K4L7-1", "uniprot_ac": "A0A0G2K4L7", "uniprot_id": "A0A0G2K4L7_RAT", "mass": { "chemical_mass": 95179.0, "monoisotopic_mass": 95179.0 }, "refseq": {}, "gene_names": [ { "name": "Polk", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A0G2K4L7", "id": "A0A0G2K4L7" } ], "protein_names": [ { "name": "DNA polymerase kappa", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K4L7/entry#names_and_taxonomy", "id": "A0A0G2K4L7" } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K4L7", "url": "https://www.uniprot.org/uniprot/A0A0G2K4L7" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "gene": [ { "name": "Polk", "url": "https://www.uniprot.org/uniprot/A0A0G2K4L7", "locus": { "chromosome": "2", "start_pos": 27822679, "end_pos": 27882313, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000060626", "url": "https://www.ensembl.org/id/ENSRNOG00000060626" } ] } } ], "crossref": [ { "id": "A0A0G2K4L7", "url": "https://alphafold.ebi.ac.uk/entry/A0A0G2K4L7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSRNOG00000060626", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000060626", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd03586", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03586", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001126", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001126", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006642", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006642", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022880", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022880", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024728", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024728", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036775", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036775", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043128", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043128", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043502", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043502", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "SWHNFLD", "url": "https://omabrowser.org/oma/group/SWHNFLD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR11076", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11076", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11076:SF33", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11076:SF33", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00817", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00817", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF11798", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11798", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF11799", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11799", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-5655862", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5655862", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-5656169", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5656169", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-5685942", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5685942", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-5693537", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5693537", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-5696397", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5696397", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-5696400", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5696400", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-6782135", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6782135", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-6782210", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6782210", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "620058", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=620058", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "A0A0G2JY51", "url": "https://www.uniprot.org/uniprot/A0A0G2JY51", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2JY51-1", "url": "https://www.uniprot.org/uniprot/A0A0G2JY51-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2K4L7", "url": "https://www.uniprot.org/uniprot/A0A0G2K4L7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2K4L7-1", "url": "https://www.uniprot.org/uniprot/A0A0G2K4L7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6A9L7", "url": "https://www.uniprot.org/uniprot/A0A8I6A9L7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6A9L7-1", "url": "https://www.uniprot.org/uniprot/A0A8I6A9L7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6GKB4", "url": "https://www.uniprot.org/uniprot/A0A8I6GKB4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6GKB4-1", "url": "https://www.uniprot.org/uniprot/A0A8I6GKB4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDNTKEKNNFKDALLLRMGLNDNKAGMEGLDKEKINKIIMEATKGSRFYGNELKKEKQVNQRIENMMQQKAQITSQQLRKAQLQVDRFAMELERNRNLNNTIVHVDMDAFYAAVEMRDNPELKEKPIAVGSMSMLATSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKEVKEILAEYDPNFMAMSLDEAYLNITQHLQERQGWPEDKRRYFIKMGNCRKIDTPRQEADELTERERSISPLLFEDSPPDLQPQGSPFQLNSEEQNNPQIAQNPVVFGTSAEEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQIVPSRSAVMDFIKDLPIRKVSGIGKVTEKMLLALGIVTCTELYQQRALLSLLFSESSWHYFLHVALGLGSTDLARDGERKSMSVERTFSEINKTEEQYSLCQELCTELAHDLQKEGLKGRTVTIKLKNVDFEVKTRASTVPSAISTAEDIFAVAKELLRTEVTAGSPQPLRLRLMGVRMSTFSNDDDRKHQQRSIIGFLQAGNQGLSPTGCTADRTDKTELVKPLETSRKKSFFDKKRSERIPNCQDPPRCKIAGEQALQASEPSQALKKMSESFKTSENSNDPQTFICPVCFREQEGISLEAFNEHVDACLDGPSTSENSEMPSYSHASSADIGQQAHRAVPLWEKRGHGDGEITSGDGADLTETEDRSPKAASMDAVGNNHSEGEGYPDSQGKSCPLSPANETVSTLSREDSAQPCTDEVVTGRALVCPVCNLEQETSDLTLFNIHVDICLNKGIIQELRNSEVNSVKQPKGSTRSTDRLQKASGKTKRAGRKTKGSTSKRTKPRDPRHTLDGFFK", "length": 851, "header": "tr|A0A0G2K4L7-1|A0A0G2K4L7_RAT Isoform 1 of DNA polymerase kappa OS=Rattus norvegicus OX=10116 GN=Polk PE=3 SV=2 CANONICAL=A0A0G2K4L7-1" }, "isoforms": [ { "isoform_ac": "A0A0G2JY51-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K4L7/entry#A0A0G2JY51-1", "sequence": { "sequence": "MDNTKEKNNFKDALLLRMGLNDNKAGMEGLDKEKINKIIMEATKGSRFYGNELKKEKQVNQRIENMMQQKAQITSQQLRKAQLQVDRFAMELERNRNLNNTIVHVDMDAFYAAVEMRDNPELKEKPIAVGSMSMLATSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKEVKEILAEYDPNFMAMSLDEAYLNITQHLQERQGWPEDKRRYFIKMGNCRKIDTPRQEADELTERERSISPLLFEDSPPDLQPQGSPFQLNSEEQNNPQIAQNPVVFGTSAEEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQIVPSRSAVMDFIKDLPIRKVSGIGKVTEKMLLALGIVTCTELYQQRALLSLLFSESSWHYFLHVALGLGSTDLARYGDRLTRTFSEINKTEEQYSLCQELCTELAHDLQKEGLKGRTVTIKLKNVDFEVKTRASTVPSAISTAEDIFAVAKELLRTEVTAGSPQPLRLRLMGVRMSTFSNDDDRKHQQRSIIGFLQAGNQGLSPTGCTADRTDKTELVKPLETSRKKSFFDKKRSERIPNCQDPPRCKIAGEQALQASEPSQALKKMSESFKTSENSNDPQTFICPVCFREQEGISLEAFNEHVDACLDGPSTSENSEMPSYSHASSADIGQQAHRAVPLWEKRGHGDGEITSGDGADLTETEDRSPKAASMDAVGNNHSEGEGYPDSQGKSCPLSPANETVSTLSREDSAQPCTDEVVTGRALVCPVCNLEQETSDLTLFNIHVDICLNKGIIQELRNSEVNSVKQPKGSTRSTDRLQKASGKTKRAGRKTKGSTSKRTKPRDPRHTLDGFFK", "length": 847, "header": "tr|A0A0G2JY51-1|A0A0G2K4L7_RAT Computationally mapped isoform of DNA polymerase kappa OS=Rattus norvegicus OX=10116 GN=Polk PE=3 SV=2 CANONICAL=A0A0G2K4L7-1" }, "locus": { "chromosome": "2", "start_pos": 27861405, "end_pos": 27823713, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000091418.2", "url": "https://www.ensembl.org/id/ENSRNOT00000091418.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000070520.2", "url": "https://www.ensembl.org/id/ENSRNOP00000070520.2" } ] } }, { "isoform_ac": "A0A0G2K4L7-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K4L7/entry#A0A0G2K4L7-1", "sequence": { "sequence": "MDNTKEKNNFKDALLLRMGLNDNKAGMEGLDKEKINKIIMEATKGSRFYGNELKKEKQVNQRIENMMQQKAQITSQQLRKAQLQVDRFAMELERNRNLNNTIVHVDMDAFYAAVEMRDNPELKEKPIAVGSMSMLATSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKEVKEILAEYDPNFMAMSLDEAYLNITQHLQERQGWPEDKRRYFIKMGNCRKIDTPRQEADELTERERSISPLLFEDSPPDLQPQGSPFQLNSEEQNNPQIAQNPVVFGTSAEEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQIVPSRSAVMDFIKDLPIRKVSGIGKVTEKMLLALGIVTCTELYQQRALLSLLFSESSWHYFLHVALGLGSTDLARDGERKSMSVERTFSEINKTEEQYSLCQELCTELAHDLQKEGLKGRTVTIKLKNVDFEVKTRASTVPSAISTAEDIFAVAKELLRTEVTAGSPQPLRLRLMGVRMSTFSNDDDRKHQQRSIIGFLQAGNQGLSPTGCTADRTDKTELVKPLETSRKKSFFDKKRSERIPNCQDPPRCKIAGEQALQASEPSQALKKMSESFKTSENSNDPQTFICPVCFREQEGISLEAFNEHVDACLDGPSTSENSEMPSYSHASSADIGQQAHRAVPLWEKRGHGDGEITSGDGADLTETEDRSPKAASMDAVGNNHSEGEGYPDSQGKSCPLSPANETVSTLSREDSAQPCTDEVVTGRALVCPVCNLEQETSDLTLFNIHVDICLNKGIIQELRNSEVNSVKQPKGSTRSTDRLQKASGKTKRAGRKTKGSTSKRTKPRDPRHTLDGFFK", "length": 851, "header": "tr|A0A0G2K4L7-1|A0A0G2K4L7_RAT Isoform 1 of DNA polymerase kappa OS=Rattus norvegicus OX=10116 GN=Polk PE=3 SV=2 CANONICAL=A0A0G2K4L7-1" }, "locus": { "chromosome": "2", "start_pos": 27861405, "end_pos": 27823713, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000078639.2", "url": "https://www.ensembl.org/id/ENSRNOT00000078639.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000073092.2", "url": "https://www.ensembl.org/id/ENSRNOP00000073092.2" } ] } }, { "isoform_ac": "A0A8I6A9L7-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K4L7/entry#A0A8I6A9L7-1", "sequence": { "sequence": "MDNTKEKNNFKDALLLRMGLNDNKAGMEGLDKEKINKIIMEATKGSRFYGNELKKEKQVNQRIENMMQQKAQITSQQLRKAQLQVDRFAMELERNRNLNNTIVHVDMDAFYAAVEMRDNPELKEKPIAVGSMSMLATSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKEVKEILAEYDPNFMAMSLDEAYLNITQHLQERQGWPEDKRRYFIKMGNCRKIDTPRQEADELTERERSISPLLFEDSPPDLQPQGSPFQLNSEEQNNPQIAQNPVVFGTSAEEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQIVPSRSAVMDFIKDLPIRKVSGIGKVTEKMLLALGIVTCTELYQQRALLSLLFSESSWHYFLHVALGLGSTDLARDGERKSMSVERTFSEINKTEEQYSLCQELCTELAHDLQKEGLKGRTVTIKLKNVDFEVKTRASTVPSAISTAEDIFAVAKELLRTEVTAGSPQPLRLRLMDRLQKASGKTKRAGRKTKGSTSKRTKPRDPRHTLDGFFK", "length": 547, "header": "tr|A0A8I6A9L7-1|A0A0G2K4L7_RAT Computationally mapped isoform of DNA polymerase kappa OS=Rattus norvegicus OX=10116 GN=Polk PE=3 SV=1 CANONICAL=A0A0G2K4L7-1" }, "locus": { "chromosome": "2", "start_pos": 27861405, "end_pos": 27823713, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000105350.1", "url": "https://www.ensembl.org/id/ENSRNOT00000105350.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000088338.1", "url": "https://www.ensembl.org/id/ENSRNOP00000088338.1" } ] } }, { "isoform_ac": "A0A8I6GKB4-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K4L7/entry#A0A8I6GKB4-1", "sequence": { "sequence": "MDNTKEKNNFKDALLLRMGLNDNKAGMEGLDKEKINKIIMEATKGSRFYGNELKKEKQVNQRIENMMQQKAQITSQQLRKAQLQVDRFAMELERNRNLNNTIVHVDMDAFYAAVEMRDNPELKEKPIAVGSMSMLATSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKEVKEILAEYDPNFMAMSLDEAYLNITQHLQERQGWPEDKRRYFIKMGNCRKIGIAPNTMLAKVCSDKNKPNGQYQIVPSRSAVMDFIKDLPIRKVSGIGKVTEKMLLALGIVTCTELYQQRALLSLLFSESSWHYFLHVALGLGSTDLARDGERKSMSVERTFSEINKTEEQYSLCQELCTELAHDLQKEGLKGRTVTIKLKNVDFEVKTRASTVPSAISTAEDIFAVAKELLRTEVTAGSPQPLRLRLMGVRMSTFSNDDDRKHQQRSIIGFLQAGNQGLSPTGCTADRTDKTELVKPLETSRKKSFFDKKRSERIPNCQDPPRCKIAGEQALQASEPSQALKKMSESFKTSENSNDPQTFICPVCFREQEGISLEAFNEHVDACLDGPSTSENSEMPSYSHASSADIGQQAHRAVPLWEKRGHGDGEITSGDGADLTETEDRSPKAASMDAVGNNHSEGEGYPDSQGKSCPLSPANETVSTLSREDSAQPCTDEVVTGRALVCPVCNLEQETSDLTLFNIHVDICLNKGIIQELRNSEVNSVKQPKGSTRSTDRLQKASGKTKRAGRKTKGSTSKRTKPRDPRHTLDGFFK", "length": 771, "header": "tr|A0A8I6GKB4-1|A0A0G2K4L7_RAT Computationally mapped isoform of DNA polymerase kappa OS=Rattus norvegicus OX=10116 GN=Polk PE=3 SV=1 CANONICAL=A0A0G2K4L7-1" }, "locus": { "chromosome": "2", "start_pos": 27861405, "end_pos": 27823713, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000094510.1", "url": "https://www.ensembl.org/id/ENSRNOT00000094510.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000092732.1", "url": "https://www.ensembl.org/id/ENSRNOP00000092732.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-RNO-5655862", "name": "Translesion synthesis by POLK", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5655862", "resource": "Reactome", "description": "Translesion synthesis by POLK" }, { "id": "R-RNO-5656169", "name": "Termination of translesion DNA synthesis", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5656169", "resource": "Reactome", "description": "Termination of translesion DNA synthesis" }, { "id": "R-RNO-5685942", "name": "HDR through Homologous Recombination (HRR)", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5685942", "resource": "Reactome", "description": "HDR through Homologous Recombination (HRR)" }, { "id": "R-RNO-5693537", "name": "Resolution of D-Loop Structures", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5693537", "resource": "Reactome", "description": "Resolution of D-Loop Structures" }, { "id": "R-RNO-5696397", "name": "Gap-filling DNA repair synthesis and ligation in GG-NER", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5696397", "resource": "Reactome", "description": "Gap-filling DNA repair synthesis and ligation in GG-NER" }, { "id": "R-RNO-5696400", "name": "Dual Incision in GG-NER", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5696400", "resource": "Reactome", "description": "Dual Incision in GG-NER" }, { "id": "R-RNO-6782135", "name": "Dual incision in TC-NER", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6782135", "resource": "Reactome", "description": "Dual incision in TC-NER" }, { "id": "R-RNO-6782210", "name": "Gap-filling DNA repair synthesis and ligation in TC-NER", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6782210", "resource": "Reactome", "description": "Gap-filling DNA repair synthesis and ligation in TC-NER" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0Y2U3-1", "protein_name": "DNA polymerase kappa", "gene_name": "POLK", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MNEERERFVRAGARETFSGLWDHVAKTGIGSNNCVRAKFLTRRSDKRTRGSSGGIKSQERYWYSESTMDNVKNVDKSSYNGGALLRMGLNDNKAGMQGLDKEKINKIIMEASKGSKFYENELKKDQQVNQRIEKMMQLKEKITQQQLLKAQLQVDKLVLELERSRNLSCTIVHIDMDAFYAAVEMRDNPELKEKPIAVGSMSMLSTSNYHARRFGVRAAMPGFIAKKLCPHLTIVPLNFEKYRKVSKEVKEILAEYDPHFMPMGLDEAYLNVTEHLEERLNWPEDKRRYFLNTENTTEKNKEDINIPGTVNIDGYSSSPELFEDGTSVMDDDSGQRDQSLKNVVVFGTSAEEAVKEIRFRIEQKTQLTASAGIAPNTMLAKMCSDRNKPNGQCRISPERQAVLDFIKDLPIRKVPGIGKVTEKMLKALGIVTCSELYQQRALLSLLFSEASWRSFLDISLGLGSTHLEKDGERKSMSTERTFSEISKAEDQYSLCQELCRELAQDLQKEGLKGKTVTLKLKNVNFEVKTRASTVLSSVSTEDEIFAVAKMLLGTEIDSVAPHPLRIRLMGVRVSGFLSEEEKKYQQKSIKSFLKSGKELDFSRLQPGRSNQENLTKNSEASSRGSFFDKKRAARQLNSNNLFPNESVGKQHFHGVKSSANFVEEANKVTDLQKSNVCEIFTCPVCFEEQSSSNLEEINRHVDECLAGSLVEDTVEISKNDLSRENTFNFLSHCKNENIDDCKENVTDQLAGTGQSASTSENSSGNSRDKKFTQIVSEKPHREKQPGDLIDIPRNASIKQCLSPKRNSQENAVQFGRMDHTEETSSSCSFEAREDSVLVCPVCNLEQKTTSLMSFNRHVDVCLNKGLIQELTEKDDCSAKTSDTENSIRVGGLSRGQKCTKPLQGTKRSGLTTSQSASKKAKSIDSKRTIEMFFK", "length": 934 }, "evidence": [ { "id": "A0A0G2K4L7", "url": "https://omabrowser.org/oma/group/A0A0G2K4L7/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0AAA9S123-1", "protein_name": "DNA polymerase kappa", "gene_name": "POLK", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MKVKSEREVAQSCPTLRNPMDCSPPGSSVHGTFQVYTMGSTKEKSDGTKEKNDNYKDDLLLRMGLNDNKAGMEGLDKEKINKIIMEATKGSRFYGNELKKEKQVNQRIENMMQQKAKITSEQLRKAQLQVDRFAVELEQSRDLNSTIVHIDMDAFYAAVEMRDNPELKDKPIAVGSMSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYQAVSREVKEILTDYDPNFMAMSLDEAYLNITKHLEERKNWPEDKRKYFITAGNSLENDKPGKEVNELSEHEGSISPLLFEDSPPDLQSPGNPSQVNFEEPNNPQIHQNSIVFGTSAEEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQILPNRQAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQQRALLSLLFSETSWHHFLHISLGLGSTHLARDGERKSMSVERTFSEISKAEEQYSLCQELCSELAQDLQKKGLKGRTVTIKLKNVNFEVKTRASTVSTVVSTAEEIFVIAKELLRTEIDADFPQPLRLRLMGVRLSGFPNEEEKKHQQRSIIGFLQPGNQALSATGCILEKTDKDQFLKPAQMSHKKSFFDKKRSERKASPQDTFTCETVNKQSLQTSQSFQVLNKKMSENLETEEKSHSCQTFTCPVCFREQGSVSLEAFNKHVDACLDGPSISGNSKMSSCSHASSTEVNEKENVCDSVSLCEKQGYETHQKNTEITSVDPIELVETTGKPSNTEDTSALSNKPSEEEECSGLSSKLFNMDPQNSCTVSLENEDVGSLRRQESPQPNLYEVISDQVLVCPVCNLEQKTSDLTLFNVHVDVCLNKGIIQELRKDKINPCNQPKESAKSTDNSGKVQKTGNKTKRPGLMTKYSASKKPKPNNPRHTLDVFFK", "length": 914 }, "evidence": [ { "id": "A0A0G2K4L7", "url": "https://omabrowser.org/oma/group/A0A0G2K4L7/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "Q9QUG2-1", "protein_name": "DNA polymerase kappa", "gene_name": "Polk", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDNTKEKDNFKDDLLLRMGLNDNKAGMEGLDKEKINKIIMEATKGSRFYGNELKKEKQVNQRIENMMQQKAQITSQQLRKAQLQVDKFAMELERNRNLNNTIVHVDMDAFYAAVEMRDNPELKDKPIAVGSMSMLATSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKEVKEILAEYDPNFMAMSLDEAYLNITQHLQERQDWPEDKRRYFIKMGNYLKIDTPRQEANELTEYERSISPLLFEDSPPDLQPQGSPFQLNSEEQNNPQIAQNSVVFGTSAEEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQILPSRSAVMDFIKDLPIRKVSGIGKVTEKMLMALGIVTCTELYQQRALLSLLFSETSWHYFLHIALGLGSTDLARDGERKSMSVERTFSEISKTEEQYSLCQELCAELAHDLQKEGLKGRTVTIKLKNVNFEVKTRASTVPAAISTAEEIFAIAKELLRTEVNVGSPHPLRLRLMGVRMSTFSSEDDRKHQQRSIIGFLQAGNQALSSTGDSLDKTDKTELAKPLEMSHKKSFFDKKRSERISNCQDTSRCKTAGQQALQILEPSQALKKLSESFETSENSNDCQTFICPVCFREQEGVSLEAFNEHVDECLDGPSTSENSKISCYSHASSADIGQKEDVHPSIPLCEKRGHENGEITLVDGVDLTGTEDRSLKAARMDTLENNRSKEECPDIPDKSCPISLENETISTLSRQDSVQPCTDEVVTGRALVCPVCNLEQETSDLTLFNIHVDICLNKGIIQELRNSEGNSVKQPKESSRSTDRLQKASGRTKRPGTKTKSSTLKKTKPRDPRHTLDGFFK", "length": 852 }, "evidence": [ { "id": "A0A0G2K4L7", "url": "https://omabrowser.org/oma/group/A0A0G2K4L7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9UBT6-1", "protein_name": "DNA polymerase kappa", "gene_name": "POLK", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDSTKEKCDSYKDDLLLRMGLNDNKAGMEGLDKEKINKIIMEATKGSRFYGNELKKEKQVNQRIENMMQQKAQITSQQLRKAQLQVDRFAMELEQSRNLSNTIVHIDMDAFYAAVEMRDNPELKDKPIAVGSMSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKEVKEILADYDPNFMAMSLDEAYLNITKHLEERQNWPEDKRRYFIKMGSSVENDNPGKEVNKLSEHERSISPLLFEESPSDVQPPGDPFQVNFEEQNNPQILQNSVVFGTSAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQILPNRQAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQQRALLSLLFSETSWHYFLHISLGLGSTHLTRDGERKSMSVERTFSEINKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAKELLKTEIDADFPHPLRLRLMGVRISSFPNEEDRKHQQRSIIGFLQAGNQALSATECTLEKTDKDKFVKPLEMSHKKSFFDKKRSERKWSHQDTFKCEAVNKQSFQTSQPFQVLKKKMNENLEISENSDDCQILTCPVCFRAQGCISLEALNKHVDECLDGPSISENFKMFSCSHVSATKVNKKENVPASSLCEKQDYEAHPKIKEISSVDCIALVDTIDNSSKAESIDALSNKHSKEECSSLPSKSFNIEHCHQNSSSTVSLENEDVGSFRQEYRQPYLCEVKTGQALVCPVCNVEQKTSDLTLFNVHVDVCLNKSFIQELRKDKFNPVNQPKESSRSTGSSSGVQKAVTRTKRPGLMTKYSTSKKIKPNNPKHTLDIFFK", "length": 870 }, "evidence": [ { "id": "A0A0G2K4L7", "url": "https://omabrowser.org/oma/group/A0A0G2K4L7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "DNA-directed DNA polymerase activity", "id": "GO:0003887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003887", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K4L7", "url": "https://www.uniprot.org/uniprot/A0A0G2K4L7" } ], "pmid": "" }, { "name": "molecular adaptor activity", "id": "GO:0060090", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060090", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K4L7", "url": "https://www.uniprot.org/uniprot/A0A0G2K4L7" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K4L7", "url": "https://www.uniprot.org/uniprot/A0A0G2K4L7" } ], "pmid": "" }, { "name": "damaged DNA binding", "id": "GO:0003684", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003684", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K4L7", "url": "https://www.uniprot.org/uniprot/A0A0G2K4L7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "nucleotide-excision repair, DNA gap filling", "id": "GO:0006297", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006297", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K4L7", "url": "https://www.uniprot.org/uniprot/A0A0G2K4L7" } ], "pmid": "" }, { "name": "DNA repair", "id": "GO:0006281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006281", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K4L7", "url": "https://www.uniprot.org/uniprot/A0A0G2K4L7" } ], "pmid": "" }, { "name": "DNA damage response", "id": "GO:0006974", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006974", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K4L7", "url": "https://www.uniprot.org/uniprot/A0A0G2K4L7" } ], "pmid": "" }, { "name": "cellular response to UV", "id": "GO:0034644", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034644", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K4L7", "url": "https://www.uniprot.org/uniprot/A0A0G2K4L7" } ], "pmid": "" }, { "name": "error-prone translesion synthesis", "id": "GO:0042276", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042276", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K4L7", "url": "https://www.uniprot.org/uniprot/A0A0G2K4L7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K4L7", "url": "https://www.uniprot.org/uniprot/A0A0G2K4L7" } ], "pmid": "" }, { "name": "nuclear body", "id": "GO:0016604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016604", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K4L7", "url": "https://www.uniprot.org/uniprot/A0A0G2K4L7" } ], "pmid": "" }, { "name": "site of DNA damage", "id": "GO:0090734", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090734", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K4L7", "url": "https://www.uniprot.org/uniprot/A0A0G2K4L7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 202, "end_pos": 204, "annotation": "n_glycosylation_sequon" }, { "start_pos": 425, "end_pos": 427, "annotation": "n_glycosylation_sequon" }, { "start_pos": 715, "end_pos": 717, "annotation": "n_glycosylation_sequon" }, { "start_pos": 736, "end_pos": 738, "annotation": "n_glycosylation_sequon" }, { "start_pos": 99, "end_pos": 101, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A0G2K4L7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 851, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A0G2K4L7-F1.pdb" } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 202, "end_pos": 204 }, { "start_pos": 425, "end_pos": 427 }, { "start_pos": 715, "end_pos": 717 }, { "start_pos": 736, "end_pos": 738 }, { "start_pos": 99, "end_pos": 101 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }