{ "uniprot_canonical_ac": "A0A0G2K470-1", "uniprot_ac": "A0A0G2K470", "uniprot_id": "A0A0G2K470_RAT", "mass": { "chemical_mass": 128839.0, "monoisotopic_mass": 128839.0 }, "refseq": {}, "gene_names": [ { "name": "Itga2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A0G2K470", "id": "A0A0G2K470" } ], "protein_names": [ { "name": "Integrin subunit alpha 2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K470/entry#names_and_taxonomy", "id": "A0A0G2K470" } ], "function": [], "disease": [ { "disease_id": "DOID:0060573", "recommended_name": { "id": "DOID:0060573", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060573", "name": "von Willebrand's disease 1", "description": "A von Willebrand's disease characterized by quantitative partial deficiency of circulating VWF that has_material_basis_in heterozygous mutation in the VWF gene on chromosome 12p13." }, "synonyms": [ { "id": "DOID:0060573", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060573", "name": "VWD type 1", "description": "" }, { "id": "DOID:0060573", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060573", "name": "VWD1", "description": "" }, { "id": "DOID:0060573", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060573", "name": "von Willebrand disease type 1", "description": "" }, { "id": "DOID:0060573", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060573", "name": "von Willebrand disease type I", "description": "" }, { "id": "MONDO:0008668", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008668", "name": "von Willebrand disease 1", "description": "Type 1 von Willebrand disease (type 1 VWD) is a form of VWD characterized by a bleeding disorder associated with a partial quantitative plasmatic deficiency of an otherwise structurally and functionally normal Willebrand factor (von Willebrand factor; VWF)." }, { "id": "MONDO:0008668", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008668", "name": "VWD type 1", "description": "" }, { "id": "MONDO:0008668", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008668", "name": "VWD1", "description": "" }, { "id": "MONDO:0008668", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008668", "name": "von Willebrand disease 1", "description": "" }, { "id": "MONDO:0008668", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008668", "name": "von Willebrand disease type 1", "description": "" }, { "id": "MONDO:0008668", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008668", "name": "von Willebrand disease type I", "description": "" }, { "id": "MONDO:0008668", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008668", "name": "von Willebrand's disease type 1", "description": "" }, { "id": "MONDO:0008668", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008668", "name": "von willebrand's disease 1", "description": "" }, { "id": "MONDO:0008668", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008668", "name": "VON WILLEBRAND disease, type 1", "description": "" }, { "id": "MONDO:0008668", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008668", "name": "VWD, type 1", "description": "" }, { "id": "MONDO:0008668", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008668", "name": "Von Willebrand disease, type 1", "description": "" }, { "id": "MIM:193400", "resource": "MIM", "url": "https://www.omim.org/entry/193400", "name": "von Willebrand disease 1", "description": "von Willebrand disease 1" } ], "evidence": [ { "id": "0060573", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0060573" } ] }, { "disease_id": "DOID:0060574", "recommended_name": { "id": "DOID:0060574", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060574", "name": "von Willebrand's disease 2", "description": "A von Willebrand's disease characterized by qualitative but not quantitative abnormalities of the VWF protein that has_material_basis_in mutation in the VWF gene which maps to chromosome 12p13." }, "synonyms": [ { "id": "DOID:0060574", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060574", "name": "VWD type 2", "description": "" }, { "id": "DOID:0060574", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060574", "name": "VWD2", "description": "" }, { "id": "DOID:0060574", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060574", "name": "von Willebrand disease type 2", "description": "" }, { "id": "DOID:0060574", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060574", "name": "von Willebrand disease type II", "description": "" }, { "id": "MONDO:0013304", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013304", "name": "von Willebrand disease 2", "description": "Type 2 von Willebrand disease (type 2 VWD) is a form of VWD characterized by a bleeding disorder associated with a qualitative deficiency and functional anomalies of the Willebrand factor (von Willebrand factor; VWF)." }, { "id": "MONDO:0013304", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013304", "name": "VWD type 2", "description": "" }, { "id": "MONDO:0013304", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013304", "name": "VWD2", "description": "" }, { "id": "MONDO:0013304", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013304", "name": "von Willebrand disease 2", "description": "" }, { "id": "MONDO:0013304", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013304", "name": "von Willebrand disease type 2", "description": "" }, { "id": "MONDO:0013304", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013304", "name": "von Willebrand disease type II", "description": "" }, { "id": "MONDO:0013304", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013304", "name": "von Willebrand disease, types 2A, 2B, 2M, and 2N", "description": "" }, { "id": "MONDO:0013304", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013304", "name": "von Willebrand's disease type 2", "description": "" }, { "id": "MONDO:0013304", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013304", "name": "von willebrand's disease 2", "description": "" }, { "id": "MONDO:0013304", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013304", "name": "VON WILLEBRAND disease, type 2", "description": "" }, { "id": "MONDO:0013304", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013304", "name": "VWD, type 2", "description": "" }, { "id": "MONDO:0013304", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013304", "name": "Von Willebrand disease, type 2", "description": "" }, { "id": "MONDO:0013304", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013304", "name": "Von Willebrand disease, type 2A", "description": "" }, { "id": "MONDO:0013304", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013304", "name": "Von Willebrand disease, type 2B", "description": "" }, { "id": "MONDO:0013304", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013304", "name": "Von Willebrand disease, type 2M", "description": "" }, { "id": "MONDO:0013304", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013304", "name": "Von Willebrand disease, type 2N", "description": "" }, { "id": "MIM:613554", "resource": "MIM", "url": "https://www.omim.org/entry/613554", "name": "von Willebrand disease 2", "description": "von Willebrand disease 2" } ], "evidence": [ { "id": "0060574", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0060574" } ] }, { "disease_id": "DOID:0060903", "recommended_name": { "id": "DOID:0060903", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060903", "name": "thrombosis", "description": "A vascular disease caused by the formation of a blood clot inside a blood vessel, obstructing the flow of blood through the circulatory system." }, "synonyms": [], "evidence": [ { "id": "0060903", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0060903" } ] }, { "disease_id": "DOID:10003", "recommended_name": { "id": "DOID:10003", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10003", "name": "sensorineural hearing loss", "description": "An inner ear disease that is characterized by hearing loss resulting from damage to the cochlea, auditory nerve and/or brainstem." }, "synonyms": [ { "id": "DOID:10003", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10003", "name": "High Frequency Hearing Loss", "description": "" }, { "id": "DOID:10003", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10003", "name": "High frequency deafness", "description": "" }, { "id": "DOID:10003", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10003", "name": "Perceptive deafness", "description": "" }, { "id": "DOID:10003", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10003", "name": "Perceptive hearing loss", "description": "" }, { "id": "DOID:10003", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10003", "name": "Perceptive hearing loss or deafness", "description": "" }, { "id": "DOID:10003", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10003", "name": "Sensorineural Deafness", "description": "" }, { "id": "DOID:10003", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10003", "name": "Sensory hearing loss", "description": "" }, { "id": "DOID:10003", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10003", "name": "central hearing loss", "description": "" }, { "id": "DOID:10003", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10003", "name": "high-frequency hearing loss", "description": "" } ], "evidence": [ { "id": "10003", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10003" } ] }, { "disease_id": "DOID:11758", "recommended_name": { "id": "DOID:11758", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11758", "name": "iron deficiency anemia", "description": "A microcytic anemia that is characterized by pallor, fatigue, lightheadedness, and weakness and has_material_basis_in low total body iron causing impaired synthesis of red blood cells." }, "synonyms": [], "evidence": [ { "id": "11758", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:11758" } ] }, { "disease_id": "DOID:13241", "recommended_name": { "id": "DOID:13241", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:13241", "name": "Behcet's disease", "description": "A vasculitis that is characterized by an autoimmune mediated inflammation of the blood vessels throughout the body leading to ulcerations on the mouth and sometimes the genitals, notorious for causing hypopyon uveitis." }, "synonyms": [ { "id": "DOID:13241", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:13241", "name": "Adamantiades-Behcet disease", "description": "" }, { "id": "DOID:13241", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:13241", "name": "Behcet syndrome", "description": "" }, { "id": "DOID:13241", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:13241", "name": "Behet's syndrome", "description": "" }, { "id": "DOID:13241", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:13241", "name": "triple symptom complex", "description": "" }, { "id": "MONDO:0007191", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007191", "name": "Behcet disease", "description": "A chronic, relapsing, multisystemic vasculitis characterized by mucocutaneous lesions, as well as articular, vascular, ocular and central nervous system manifestations." }, { "id": "MONDO:0007191", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007191", "name": "Adamantiades-Behcet disease", "description": "" }, { "id": "MONDO:0007191", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007191", "name": "Bechet syndrome", "description": "" }, { "id": "MONDO:0007191", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007191", "name": "Behcet disease", "description": "" }, { "id": "MONDO:0007191", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007191", "name": "Behcet syndrome", "description": "" }, { "id": "MONDO:0007191", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007191", "name": "Behcet's syndrome", "description": "" }, { "id": "MONDO:0007191", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007191", "name": "Behet's syndrome", "description": "" }, { "id": "MONDO:0007191", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007191", "name": "Behet disease", "description": "" }, { "id": "MONDO:0007191", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007191", "name": "Behet syndrome", "description": "" }, { "id": "MONDO:0007191", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007191", "name": "Behet-Adamantiades syndrome", "description": "" }, { "id": "MONDO:0007191", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007191", "name": "Morbus Behet's syndrome", "description": "" }, { "id": "MONDO:0007191", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007191", "name": "silk road disease", "description": "" }, { "id": "MONDO:0007191", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007191", "name": "triple symptom complex", "description": "" }, { "id": "MONDO:0007191", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007191", "name": "BD", "description": "" }, { "id": "MONDO:0007191", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007191", "name": "Behcet's disease", "description": "" }, { "id": "MONDO:0007191", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007191", "name": "Behet's disease", "description": "" }, { "id": "MONDO:0007191", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007191", "name": "Behets disease", "description": "" } ], "evidence": [ { "id": "13241", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:13241" } ] }, { "disease_id": "DOID:1588", "recommended_name": { "id": "DOID:1588", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1588", "name": "thrombocytopenia", "description": "A blood platelet disease that is characterized by low a platelet count in the blood." }, "synonyms": [ { "id": "MONDO:0012775", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012775", "name": "thrombocytopenia 4", "description": "Any thrombocytopenia in which the cause of the disease is a mutation in the CYCS gene." }, { "id": "MONDO:0012775", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012775", "name": "CYCS thrombocytopenia", "description": "" }, { "id": "MONDO:0012775", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012775", "name": "thrombocytopenia 4", "description": "" }, { "id": "MONDO:0012775", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012775", "name": "thrombocytopenia caused by mutation in CYCS", "description": "" }, { "id": "MONDO:0012775", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012775", "name": "thrombocytopenia type 4", "description": "" }, { "id": "MONDO:0012775", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012775", "name": "THC4", "description": "" }, { "id": "MONDO:0012775", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012775", "name": "thrombocytopenia, autosomal dominant, 4", "description": "" }, { "id": "MONDO:0010308", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010308", "name": "thrombocytopenia, X-linked, with or without dyserythropoietic anemia", "description": "An X-linked condition caused by mutation(s) in the GATA1 gene, encoding erythroid transcription factor. It is characterized by thrombocytopenia, as well as abnormal platelet function and morphology. Dyserythropoietic anemia of variable severity may also be present." }, { "id": "MONDO:0010308", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010308", "name": "X-linked thrombocytopenia, with or without dyserythropoietic Anaemia", "description": "" }, { "id": "MONDO:0010308", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010308", "name": "X-linked thrombocytopenia, with or without dyserythropoietic Anemia", "description": "" }, { "id": "MONDO:0010308", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010308", "name": "thrombocytopenia, X-linked, with or without dyserythropoietic anemia", "description": "" }, { "id": "MONDO:0010308", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010308", "name": "thrombocytopenia, X-linked, with or without dyserythropoietic anemia, X-linked recessive", "description": "" }, { "id": "MONDO:0010308", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010308", "name": "XLTDA", "description": "" }, { "id": "MONDO:0008555", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008555", "name": "thrombocytopenia 2", "description": "An autosomal dominant disorder caused by mutation(s) in the ANKRD26 gene, encoding ANKRD26 protein. Additionally, in one family, a mutation(s) has been identified in the MASTL gene, encoding serine/threonine-protein kinase greatwall. The condition is characterized by mild to moderate bruisability." }, { "id": "MONDO:0008555", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008555", "name": "thrombocytopenia 2", "description": "" }, { "id": "MONDO:0008555", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008555", "name": "thrombocytopenia type 2", "description": "" }, { "id": "MONDO:0008555", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008555", "name": "THC2", "description": "" }, { "id": "MONDO:0008555", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008555", "name": "thrombocytopenia autosomal dominant 2", "description": "" }, { "id": "MONDO:0008555", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008555", "name": "thrombocytopenia, autosomal dominant, 2", "description": "" }, { "id": "MONDO:0010120", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010120", "name": "thrombocytopenia 3", "description": "" }, { "id": "MONDO:0010120", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010120", "name": "THC3", "description": "" }, { "id": "MONDO:0010120", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010120", "name": "thrombocytopenia 3", "description": "" }, { "id": "MONDO:0010120", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010120", "name": "thrombocytopenia, autosomal recessive, 3", "description": "" }, { "id": "MONDO:0010743", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010743", "name": "thrombocytopenia 1", "description": "" }, { "id": "MONDO:0010743", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010743", "name": "X-linked thrombocytopenia with normal platelets", "description": "" }, { "id": "MONDO:0010743", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010743", "name": "thrombocytopenia 1", "description": "" }, { "id": "MONDO:0010743", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010743", "name": "thrombocytopenia type 1", "description": "" }, { "id": "MONDO:0010743", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010743", "name": "thrombocytopenia, X-linked, X-linked recessive", "description": "" }, { "id": "MONDO:0010743", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010743", "name": "thrombocytopenia, X-linked, intermittent, X-linked recessive", "description": "" }, { "id": "MONDO:0010743", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010743", "name": "THC", "description": "" }, { "id": "MONDO:0010743", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010743", "name": "THC1", "description": "" }, { "id": "MONDO:0010743", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010743", "name": "X-linked thrombocytopenia", "description": "" }, { "id": "MONDO:0010743", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010743", "name": "XLT", "description": "" }, { "id": "MONDO:0010743", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010743", "name": "thrombocytopenia, X-linked", "description": "" }, { "id": "MONDO:0010743", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010743", "name": "thrombocytopenia, X-linked, 1", "description": "" }, { "id": "MONDO:0010743", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010743", "name": "thrombocytopenia, X-linked, intermittent", "description": "" }, { "id": "MIM:612004", "resource": "MIM", "url": "https://www.omim.org/entry/612004", "name": "Thrombocytopenia 4", "description": "Thrombocytopenia 4" }, { "id": "MIM:300367", "resource": "MIM", "url": "https://www.omim.org/entry/300367", "name": "X-linked dyserythropoietic anemia and thrombocytopenia", "description": "X-linked dyserythropoietic anemia and thrombocytopenia" }, { "id": "MIM:188000", "resource": "MIM", "url": "https://www.omim.org/entry/188000", "name": "Thrombocytopenia 2", "description": "Thrombocytopenia 2" }, { "id": "MIM:273900", "resource": "MIM", "url": "https://www.omim.org/entry/273900", "name": "Thrombocytopenia 3", "description": "Thrombocytopenia 3" }, { "id": "MIM:313900", "resource": "MIM", "url": "https://www.omim.org/entry/313900", "name": "Thrombocytopenia 1", "description": "Thrombocytopenia 1" } ], "evidence": [ { "id": "1588", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1588" } ] }, { "disease_id": "DOID:1727", "recommended_name": { "id": "DOID:1727", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1727", "name": "retinal vein occlusion", "description": "" }, "synonyms": [ { "id": "DOID:1727", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1727", "name": "Occlusion, of retinal vein", "description": "" } ], "evidence": [ { "id": "1727", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1727" } ] }, { "disease_id": "DOID:2219", "recommended_name": { "id": "DOID:2219", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2219", "name": "Glanzmann's thrombasthenia", "description": "A blood coagulation disease characterized by autosomal recessive inheritance of failure of platelet aggregation and absent or diminished clot retraction that has_material_basis_in mutation in the ITGA2B or ITGB3 genes on chromosome 17q21.32." }, "synonyms": [ { "id": "DOID:2219", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2219", "name": "BDPLT2", "description": "" }, { "id": "DOID:2219", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2219", "name": "Glanzmann thrombasthenia", "description": "" }, { "id": "DOID:2219", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2219", "name": "Glycoprotein IIb/IIIa defect", "description": "" }, { "id": "DOID:2219", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2219", "name": "Thrombocytasthenia", "description": "" }, { "id": "DOID:2219", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2219", "name": "deficiency of GP IIb-IIIa complex", "description": "" }, { "id": "DOID:2219", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2219", "name": "deficiency of glycoprotein complex IIb-IIIa", "description": "" }, { "id": "DOID:2219", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2219", "name": "deficiency of platelet fibrinogen receptor", "description": "" }, { "id": "DOID:2219", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2219", "name": "platelet glycoprotein IIb-IIIa deficiency", "description": "" }, { "id": "DOID:2219", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2219", "name": "platelet-type bleeding disorder 2", "description": "" }, { "id": "DOID:2219", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2219", "name": "thrombasthenia of Glanzmann and Naegeli", "description": "" }, { "id": "MONDO:0031332", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0031332", "name": "Glanzmann thrombasthenia 1", "description": "A bleeding syndrome characterized by spontaneous mucocutaneous bleeding and an exaggerated response to trauma due to a constitutional thrombocytopenia" }, { "id": "MONDO:0031332", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0031332", "name": "Glanzmann thrombasthenia", "description": "" }, { "id": "MONDO:0031332", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0031332", "name": "Glanzmann's thrombasthenia", "description": "" }, { "id": "MONDO:0031332", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0031332", "name": "BDPLT2", "description": "" }, { "id": "MONDO:0031332", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0031332", "name": "Glanzmann thrombasthenia 1", "description": "" }, { "id": "MONDO:0031332", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0031332", "name": "Thrombocytasthenia", "description": "" }, { "id": "MONDO:0031332", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0031332", "name": "deficiency of GP IIb-IIIa complex", "description": "" }, { "id": "MONDO:0031332", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0031332", "name": "deficiency of glycoprotein complex IIb-IIIa", "description": "" }, { "id": "MONDO:0031332", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0031332", "name": "deficiency of platelet fibrinogen receptor", "description": "" }, { "id": "MONDO:0031332", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0031332", "name": "glycoprotein IIb/IIIa defect", "description": "" }, { "id": "MONDO:0031332", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0031332", "name": "platelet glycoprotein IIb-IIIa deficiency", "description": "" }, { "id": "MONDO:0031332", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0031332", "name": "platelet-type bleeding disorder 2", "description": "" }, { "id": "MONDO:0031332", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0031332", "name": "thrombasthenia", "description": "" }, { "id": "MONDO:0031332", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0031332", "name": "thrombasthenia of Glanzmann and Naegeli", "description": "" }, { "id": "MONDO:0031332", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0031332", "name": "Diacyclothrombopathia 2B 3A", "description": "" }, { "id": "MONDO:0031332", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0031332", "name": "GP IIb-IIIa Complex, deficiency of", "description": "" }, { "id": "MONDO:0031332", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0031332", "name": "GT", "description": "" }, { "id": "MONDO:0031332", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0031332", "name": "Glanzmann thrombasthenia type A", "description": "" }, { "id": "MONDO:0031332", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0031332", "name": "Platelet fibrinogen receptor, deficiency of", "description": "" }, { "id": "MONDO:0031332", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0031332", "name": "Platelet glycoprotein 2B 3A deficiency", "description": "" }, { "id": "MONDO:0031332", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0031332", "name": "Platelet glycoprotein IIb-IIIa deficiency", "description": "" }, { "id": "MONDO:0031332", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0031332", "name": "bleeding disorder, Platelet-type, 2", "description": "" }, { "id": "MONDO:0031332", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0031332", "name": "deficiency of GP 2B 3A complex", "description": "" }, { "id": "MONDO:0031332", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0031332", "name": "glycoprotein Complex IIb-IIIa, deficiency of", "description": "" }, { "id": "MIM:273800", "resource": "MIM", "url": "https://www.omim.org/entry/273800", "name": "Glanzmann thrombasthenia 1", "description": "Glanzmann thrombasthenia 1" } ], "evidence": [ { "id": "2219", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:2219" } ] }, { "disease_id": "DOID:2349", "recommended_name": { "id": "DOID:2349", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2349", "name": "arteriosclerosis", "description": "An artery disease that is characterized by a thickening and hardening of arterial walls in the arteries." }, "synonyms": [ { "id": "DOID:2349", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2349", "name": "Arteriosclerotic vascular disease", "description": "" } ], "evidence": [ { "id": "2349", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:2349" } ] }, { "disease_id": "DOID:3891", "recommended_name": { "id": "DOID:3891", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3891", "name": "placental insufficiency", "description": "A placenta disease that is characterized by insufficient blood flow to the placenta during pregnancy." }, "synonyms": [], "evidence": [ { "id": "3891", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:3891" } ] }, { "disease_id": "DOID:5844", "recommended_name": { "id": "DOID:5844", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5844", "name": "myocardial infarction", "description": "A coronary artery disease characterized by myocardial cell death (myocardial necrosis) due to prolonged ischaemia." }, "synonyms": [ { "id": "DOID:5844", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5844", "name": "Myocardial infarct", "description": "" }, { "id": "DOID:5844", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5844", "name": "heart attack", "description": "" }, { "id": "MONDO:0012058", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012058", "name": "myocardial infarction, susceptibility to, 2", "description": "" }, { "id": "MONDO:0012058", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012058", "name": "myocardial infarction, susceptibility to, 2", "description": "" }, { "id": "MONDO:0012058", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012058", "name": "myocardial infarction, susceptibility to, type 2", "description": "" }, { "id": "MONDO:0012058", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012058", "name": "Mci2", "description": "" } ], "evidence": [ { "id": "5844", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:5844" } ] }, { "disease_id": "DOID:8805", "recommended_name": { "id": "DOID:8805", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8805", "name": "intermediate coronary syndrome", "description": "" }, "synonyms": [ { "id": "DOID:8805", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8805", "name": "Angina at rest", "description": "" }, { "id": "DOID:8805", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8805", "name": "Anginal chest pain at rest", "description": "" }, { "id": "DOID:8805", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8805", "name": "Impending infarction", "description": "" }, { "id": "DOID:8805", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8805", "name": "Preinfarction angina", "description": "" }, { "id": "DOID:8805", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8805", "name": "Unstable angina", "description": "" }, { "id": "DOID:8805", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8805", "name": "Worsening angina", "description": "" } ], "evidence": [ { "id": "8805", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:8805" } ] }, { "disease_id": "DOID:8947", "recommended_name": { "id": "DOID:8947", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8947", "name": "diabetic retinopathy", "description": "" }, "synonyms": [ { "id": "DOID:8947", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8947", "name": "Retinal abnormality - diabetes-related", "description": "" } ], "evidence": [ { "id": "8947", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:8947" } ] }, { "disease_id": "DOID:9351", "recommended_name": { "id": "DOID:9351", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9351", "name": "diabetes mellitus", "description": "A glucose metabolism disease that is characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both." }, "synonyms": [ { "id": "DOID:9351", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9351", "name": "diabetes", "description": "" } ], "evidence": [ { "id": "9351", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:9351" } ] }, { "disease_id": "DOID:9352", "recommended_name": { "id": "DOID:9352", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9352", "name": "type 2 diabetes mellitus", "description": "A diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin." }, "synonyms": [ { "id": "DOID:9352", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9352", "name": "NIDDM", "description": "" }, { "id": "DOID:9352", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9352", "name": "non-insulin-dependent diabetes mellitus", "description": "" }, { "id": "DOID:9352", 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"MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, type 2, protection against", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, type 2, susceptibility to", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, type II, susceptibility to", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "hypertension, insulin resistance-related, susceptibility to", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "insulin resistance, susceptibility to", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "maturity-onset diabetes", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "type 2 diabetes mellitus, susceptibility to", "description": "" }, { "id": "MONDO:0011027", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011027", "name": "diabetes mellitus, noninsulin-dependent, 1", "description": "" }, { "id": "MONDO:0011027", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011027", "name": "diabetes mellitus, noninsulin-dependent 1", "description": "" }, { "id": "MONDO:0011027", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011027", "name": "diabetes mellitus, noninsulin-dependent, 1", "description": "" }, { "id": "MONDO:0011027", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011027", "name": "diabetes mellitus, noninsulin-dependent, type 1", "description": "" }, { "id": "MONDO:0011027", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011027", "name": "NIDDM1", "description": "" }, { "id": "MONDO:0011027", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011027", "name": "noninsulin-dependent diabetes mellitus 1", "description": "" }, { "id": "MONDO:0011072", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011072", "name": "diabetes mellitus, noninsulin-dependent, 2", "description": "" }, { "id": "MONDO:0011072", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011072", "name": "NIDDM2", "description": "" }, { "id": "MONDO:0011072", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011072", "name": "diabetes mellitus, noninsulin-dependent, 2", "description": "" }, { "id": "MONDO:0011072", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011072", "name": "noninsulin-dependent diabetes mellitus 2", "description": "" }, { "id": "MONDO:0011363", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011363", "name": "diabetes mellitus, noninsulin-dependent, 3", "description": "" }, { "id": "MONDO:0011363", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011363", "name": "diabetes mellitus, noninsulin-dependent, 3", "description": "" }, { "id": "MONDO:0011363", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011363", "name": "diabetes mellitus, noninsulin-dependent, type 3", "description": "" }, { "id": "MONDO:0011363", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011363", "name": "type 2 diabetes mellitus 3", "description": "" }, { "id": "MONDO:0011363", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011363", "name": "NIDDM3", "description": "" }, { "id": "MONDO:0011363", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011363", "name": "noninsulin-dependent diabetes mellitus 3", "description": "" }, { "id": "MIM:125853", "resource": "MIM", "url": "https://www.omim.org/entry/125853", "name": "Type 2 diabetes mellitus", "description": "Type 2 diabetes mellitus" }, { "id": "MIM:601283", "resource": "MIM", "url": "https://www.omim.org/entry/601283", "name": "Type 2 diabetes mellitus 1", "description": "Type 2 diabetes mellitus 1" } ], "evidence": [ { "id": "9352", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:9352" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K470", "url": "https://www.uniprot.org/uniprot/A0A0G2K470" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "gene": [ { "name": "Itga2", "url": "https://www.uniprot.org/uniprot/A0A0G2K470", "locus": { "chromosome": "2", "start_pos": 46523948, "end_pos": 46621481, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000058111", "url": "https://www.ensembl.org/id/ENSRNOG00000058111" } ] } } ], "crossref": [ { "id": "A0A0G2K470", "url": "https://alphafold.ebi.ac.uk/entry/A0A0G2K470", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSRNOG00000058111", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000058111", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01469", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01469", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "170921", "url": "https://www.ncbi.nlm.nih.gov/gene/170921", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000413", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000413", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002035", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002035", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013517", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013517", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013519", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013519", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018184", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018184", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028994", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028994", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032695", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032695", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036465", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036465", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048285", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048285", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048286", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048286", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IQYASQW", "url": "https://omabrowser.org/oma/group/IQYASQW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A0G2K470", "url": "https://www.orthodb.org/?gene=A0A0G2K470", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23220", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23220", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23220:SF23", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23220:SF23", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00092", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00092", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00357", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00357", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF01839", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01839", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF20805", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20805", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF20806", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20806", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-216083", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-3000170", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3000170", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-3000178", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3000178", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-8874081", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8874081", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "XP_001075558", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001075558", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "621632", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=621632", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "A0A0G2K470", "url": "https://www.uniprot.org/uniprot/A0A0G2K470", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2K470-1", "url": "https://www.uniprot.org/uniprot/A0A0G2K470-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGPGQAGGALLLQLLLLTQGLLSCLAYNVGLPGAKIFSGSSSEQFGYSVQQLTTPQGNWLLVGSPWSGFPDNRMGDVYKCPVDLPTATCEKLNLQNSASISNVTEIKTNMSLGLTLTRNPGTGGFLTCGPLWAHQCGNQYYATGICSDVSPDFQSLTSFSPAVQACPSLVDVVVVCDESNSIYPWEAVKNFLEKFVQGLDIGPKKTQVALIQYANDPRVVFNLTTYKNKEDMVQATSETRQYGGDLTNTFKAIQFARDIAYLPESGGRPGATKVMVVVTDGESHDGSKLQTVIQQCNDDEILRFGIAVLGYLNRNALDTKNLIKEIKAIASTPTERYFFNVADEAALLEKAGTLGEHIFSIEGTVQGGDNFQMEMAQVGFSADYSPQNDILMLGAVGAFDWSGTVVQETSYEHLIFPKQAFDQVLQDRNHSSFLGYSVAAISTENGVHFVAGAPRANYTGQIVLYSVNKHGNVTVIQSHRGDQIGSYFGSVLCSVDVDKDTITDVLLVGAPMYMNDLKKEEGKVYLFTITKGVLNQHQFLEGPEGTGNARFGSAIAALSDINMDGFNDVIVGSPVENENSGAVYIYNGHQGTIRTKYSQKILGSDGAFKSHLQFFGRSLDGYGDLNGDSITDVSIGALGQVVQLWSQSVADVATEASFTPDKIILLNKEAKITLKLCFRAKFRPPGQNHQVAILFNMTLDADQYSSRVTSRGIFRENSERFLQKTMVVSEVENCSEYHISIQKPSDVVNPLDLRVDISLEKPGTSPALEAYSETVKVFSIPFYKECGSDGICISDLILDVRQLPALRNQPFIVSNQNKRLTFSVTLKNRGESAYNTAVLAEFSENLFFASFSMPVDGTEVTCQIGSSQKSVTCDVGYPALKSEQQVTFTINFDFNLQNLQNQAAINFQAFSESQETNKADNSVSLIVPLLYDAELHLTRSTNINFYEISSDENAPSVINSVEDIGPEFIFSLKITAGSAPVSMASVTIHIPLHTKEKNPLLYLTGIQTDKAGDISCRAEINPLNLPHTASPVSFKSENFRHMKELDCKTTSCSNVSCWLKDLHMKAEYFINVTTRVWNRTFAASTFQTVQLTAAAEIDTHNPQLFVIEENAVTIPLMIMKPTEKAEVPTGVIIGSIIAGILLLLAMVAGLWKLGFFKRQYKKMGQNPDETDETTELNS", "length": 1178, "header": "tr|A0A0G2K470-1|A0A0G2K470_RAT Isoform 1 of Integrin subunit alpha 2 OS=Rattus norvegicus OX=10116 GN=Itga2 PE=3 SV=1 CANONICAL=A0A0G2K470-1" }, "isoforms": [ { "isoform_ac": "A0A0G2K470-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K470/entry#A0A0G2K470-1", "sequence": { "sequence": "MGPGQAGGALLLQLLLLTQGLLSCLAYNVGLPGAKIFSGSSSEQFGYSVQQLTTPQGNWLLVGSPWSGFPDNRMGDVYKCPVDLPTATCEKLNLQNSASISNVTEIKTNMSLGLTLTRNPGTGGFLTCGPLWAHQCGNQYYATGICSDVSPDFQSLTSFSPAVQACPSLVDVVVVCDESNSIYPWEAVKNFLEKFVQGLDIGPKKTQVALIQYANDPRVVFNLTTYKNKEDMVQATSETRQYGGDLTNTFKAIQFARDIAYLPESGGRPGATKVMVVVTDGESHDGSKLQTVIQQCNDDEILRFGIAVLGYLNRNALDTKNLIKEIKAIASTPTERYFFNVADEAALLEKAGTLGEHIFSIEGTVQGGDNFQMEMAQVGFSADYSPQNDILMLGAVGAFDWSGTVVQETSYEHLIFPKQAFDQVLQDRNHSSFLGYSVAAISTENGVHFVAGAPRANYTGQIVLYSVNKHGNVTVIQSHRGDQIGSYFGSVLCSVDVDKDTITDVLLVGAPMYMNDLKKEEGKVYLFTITKGVLNQHQFLEGPEGTGNARFGSAIAALSDINMDGFNDVIVGSPVENENSGAVYIYNGHQGTIRTKYSQKILGSDGAFKSHLQFFGRSLDGYGDLNGDSITDVSIGALGQVVQLWSQSVADVATEASFTPDKIILLNKEAKITLKLCFRAKFRPPGQNHQVAILFNMTLDADQYSSRVTSRGIFRENSERFLQKTMVVSEVENCSEYHISIQKPSDVVNPLDLRVDISLEKPGTSPALEAYSETVKVFSIPFYKECGSDGICISDLILDVRQLPALRNQPFIVSNQNKRLTFSVTLKNRGESAYNTAVLAEFSENLFFASFSMPVDGTEVTCQIGSSQKSVTCDVGYPALKSEQQVTFTINFDFNLQNLQNQAAINFQAFSESQETNKADNSVSLIVPLLYDAELHLTRSTNINFYEISSDENAPSVINSVEDIGPEFIFSLKITAGSAPVSMASVTIHIPLHTKEKNPLLYLTGIQTDKAGDISCRAEINPLNLPHTASPVSFKSENFRHMKELDCKTTSCSNVSCWLKDLHMKAEYFINVTTRVWNRTFAASTFQTVQLTAAAEIDTHNPQLFVIEENAVTIPLMIMKPTEKAEVPTGVIIGSIIAGILLLLAMVAGLWKLGFFKRQYKKMGQNPDETDETTELNS", "length": 1178, "header": "tr|A0A0G2K470-1|A0A0G2K470_RAT Isoform 1 of Integrin subunit alpha 2 OS=Rattus norvegicus OX=10116 GN=Itga2 PE=3 SV=1 CANONICAL=A0A0G2K470-1" }, "locus": { "chromosome": "2", "start_pos": 46621327, "end_pos": 46523965, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000077401.2", "url": "https://www.ensembl.org/id/ENSRNOT00000077401.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000072929.1", "url": "https://www.ensembl.org/id/ENSRNOP00000072929.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-RNO-216083", "name": "Integrin cell surface interactions", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-216083", "resource": "Reactome", "description": "Integrin cell surface interactions" }, { "id": "R-RNO-3000170", "name": "Syndecan interactions", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3000170", "resource": "Reactome", "description": "Syndecan interactions" }, { "id": "R-RNO-3000178", "name": "ECM proteoglycans", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3000178", "resource": "Reactome", "description": "ECM proteoglycans" }, { "id": "R-RNO-8874081", "name": "MET activates PTK2 signaling", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8874081", "resource": "Reactome", "description": "MET activates PTK2 signaling" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0YFV5-1", "protein_name": "Integrin subunit alpha 2", "gene_name": "ITGA2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MASASAALLLALGFLHNCCEAYNVGLLKAKIFSGPSREQFGYAVQQFINEQGKWLLVGSPWSGYPVNRTGDIYACPVGTPKTTCKKLNLQALINIPNVTEIKEDMNLGLTLIQNSKTGGFLTCGPLWAQQCGSQHYATGVCSEISPSFQILRSFSPAVQKCSSVIDIVVVCDESNSIYPWDAVRAFLKKFVQGLDIGINKTQVGLIQYANNPRVVFKLNEYRTKDDVVNATEKTFQQGGDLTNTFKAIDYARQHAFSAESGGRPTATKVMVVVTDGESHDGSNLKTVIGRCNEDNITRFGIAVLGYLIRNELDTKNLIKEIKGIASHPTEKYFFNVSSEAALLEEAGTLGERIFSIEGTDQGDTFQMEMSQVGFSAYFSEKKDVLLLGAVGAYDWSGTVLQESSNRVTTFPSNVFEKILQDRNHSSYLGYSVAVLSTQSSIYFVAGAPRSNYTGRVVVYDVDSQGNISIVQSQRGEQIGSYFGSVVCSVDVNKDSVTDVLLVGAPMFMNDMKKEEGRVYMFSITKGILDQQELLQGPQGSENARFGSAIAALTDIDLDGFNDIVIGAPLENQNSGAIYIYNGFQKTIRTKYSQKILGSDSAFGKRLKFFGRSVDGHRDLDDNDITDVSVGADGNVVLLWSQSIANVSVIALFTPEKISLLNKNTEITVKICFQATFRPAKRDNQVAIKCNATLDADLQSSRVTSRGLFKENNERYMQRDVMVTHSMNCVQDIFNVQEPSDAVNSLNVRIDIGLANPGTSPVLDTSSPASVAYSIPFIKDCGEDELCICDLVLNIQQKGDDGKQQFIVSSKNKRLTFNVKLRNKKENAYNTRIQATFSDNLFFASSSLPSDGTEVSCQTGTSQTTVICQISYPVFRTGQQVSFDISFDFNLKNLQNMAVLSFHALSESKEEQEPDNQISLSIPLRYDAEIHFTRLANINFYEVYSGHNIPSTVNNFEDIGPMFNFSVKVTTGSIPVKMASVKIHLPELTSKDNALMYITAVDTDQARGVTCQVQINPLQIGIRPYSASFKKENLRAVKELNCKNAKCSTITCKLEDLMLKGEYFVNVSTRIWNSTFAVSTFQTVQLFAEAEINVHNTDLFIIGENTLTIPVTIIKPDEKAEIPIGVVIGSILAGLLLLLALVAVLWKLGFFKRQYEKMTQDIEDIDEITELTKDKD", "length": 1175 }, "evidence": [ { "id": "A0A0G2K470", "url": "https://omabrowser.org/oma/group/A0A0G2K470/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1MBA3-1", "protein_name": "Integrin subunit alpha 2", "gene_name": "ITGA2", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MRPGRTGGTPLQLVLVFSQGILNCCVAYNVGLPKAKIFSGPSSEQFGYAVQQFINPKGNWLLVGSPWSGFPKNRMGDVYKCPVDLSTTTCEKLNLQTSTSMSNVTEMKTNMSLGLTLTRNVGTGGFLTCGPLWAQQCGSQYYTTGVCSDVSPDFQLRTSFAPAVQTCPSFIDVVVVCDESNSIYPWDAVKNFLEKFVQGLDIGPTKTQMGLIQYANNPRVVFNLNTFKSKDEMIKATSQTFQYGGDLTNTFKAIQYARDTAYSTAAGGRPGATKVMVVVTDGESHDGSKLKAVIDQCNKDNILRFGIAVLGYLNRNALDTKNLIKEIKAIASIPTERHFFNVSDEADLLEKAGTIGEQIFSIEGTVQGGDNFQMEMSQVGFSAEYSPQNNILMLGAVGAYDWSGTVVQKTPHGHLIFSKQAFEQILQDRNHSSYLGYSVASISTGNSVHFVAGAPRANYTGQIVLYSVNENGNVTVIQSHRGDQIGSYFGSVLCAVDVNKDTITDVLLVGAPMYMNDLKKEEGRVYLFTITKGILNWHQFLEGPKGLENARFGSAIAALSDINMDGFNDVIVGSPLENQNSGAVYIYNGHEGMIRLRYSQKILGSDRAFSSHLQYFGRSLDGYGDLNGDSITDVSVGAFGQVVQLWSQSIADVSVDASFTPKKITLLNKNAEIKLKLCFSAKFRPTNQNNQVAIVYNITIDEDQFSSRVISRGLFKENNERCLQKTMIVSQAQRCSEYIIHIQEPSDIISPLNLCMNISLENPGTNPALEAYSETVKVFSIPFHKDCGDDGVCISDLVLNVQQLPATQQQPFIVSNQNKRLTFSVQLKNKKESAYNTEIVVDFSENLFFASWSMPVDGTEVTCQIASSQKSVTCNVGYPALKSKQQVTFTINFDFNLQNLQNQASISFRALSESQEENMADNSVNLKLSLLYDAEIHITRSTNINFYEVSLDGNVSSVVHSFEDIGPKFIFSIKVTTGSVPVSMASVIIHIPQYTKDKNPLMYLTGVHTDQAGDISCEAEINPLKIGQTSSSVSFKSENFRHIKELNCRTASCSNIMCWLRDLQVKGEYFLNVSTRIWNGTFAASTFQTVQLTAAAEIDTYNPQIYVIEENTVTIPLTIMKPHEKVEVPTGVIVGSVIAGILLLLALVAILWKLGFFKRKYEKMAKNPDETDETTELNS", "length": 1179 }, "evidence": [ { "id": "A0A0G2K470", "url": "https://omabrowser.org/oma/group/A0A0G2K470/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "F1SMF4-1", "protein_name": "Integrin subunit alpha 2", "gene_name": "ITGA2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRPRPTSGARLRLLLMLTQGILNCCVAYNVGLPEAKIFSGPSSEQFGYAVQQFINPKGNWLLVGSPWSGFPENRMGDVYKCPIDPSTTTCEKLNLQTSTSISNVTEMKTNMSLGLTLTRNAGTGGFLTCGPLWAQQCGSQYYTTGVCSDVSPDFQLLTSFSPAVQACPSLIDVVVVCDESNSIYPWDAVKNFLEKFVQGLDIPTKTQVGLIQYANNPRVVFNLNTFKTKAEMVEATSHTTQYGGDLTNTFKAIQYARDSAYSAAAGGRPGATKVMVVVTDGESHDGSMLKAVIDQCNNDNILRFGIAVLGYLNRNALDTKNLIKEIKAIASIPTERYFFNVSDEADLLEKAGTLGEQIFSIEGTVQGGDNFQMEMSQVGFSADYAPQNDVLMLGAVGAYDWSGTVVQQTPHGHLIFPKQAFDQILQDRNHSSYLGYSVASISTGKSIHFVAGAPRANYTGQIVLYSVNEDGNVTVIQSHRGDQIGSYFGSVLCAVDVDKDTITDVLLVGAPMYMNDLKKEEGRVYLFTITKGVLNWHQFLEGPEGVENARFGSAIAALADINMDGFNDVIVGSPLENQNSGAVYIYNGHEGTIRLRYSQKILGSDGAFRSRLQYFGRSLDGYGDLNGDSITDVSVGAFGQVVQLWSQTIADVSVDASFTPEKIILLNKNAELNLKLCFSAKFRPTDPNNQVAIIYNITIDADQYSSRVTSRGLFKENNERCLQKTMIVKQAQSCSEHIIHIQKPSDVVNSLDLCVNISLENPGTSPALEAYSESAKVFSIPFYKDCGDDGICISDLVLDVQQLPATQQQPFIVSNQNKRLTFSVTLKNKKESAYNTGIVIAFSENLFFASWSMPVDGTEVTCQIPSSQKSVTCDVGYPALKREEQVTFTINFDFNLQNLQNRASVSFQALSESNEENKADNSVSFNFSLLYDAEIHITRFTNINFYEVSSDGNIPSTVHSFEDIGPKFTFSIKVTTGSVPVSMASVSIHIPQYTKGKNPLMYVTGVHTDQVGDISCNAEINPLKIGQTSSSLSFKSENFRHIKELNCRTAACSNITCWLKDLQVKGEYFLNVSTRIWNGTFATSTFQTVQLTAAAEIDTYNPQIYVIEENTVMIPITIMKPHEKAEVPTGVIIGSVIAGILLLLALVAVLWKLGFFKRKYEKMTKNPDEIDETTELNS", "length": 1178 }, "evidence": [ { "id": "A0A0G2K470", "url": "https://omabrowser.org/oma/group/A0A0G2K470/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P17301-1", "protein_name": "Integrin alpha-2", "gene_name": "ITGA2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": 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"length": 1181 }, "evidence": [ { "id": "47569005", "url": "http://www.informatics.jax.org/homology/47569005", "database": "MGI" }, { "id": "A0A0G2K470", "url": "https://omabrowser.org/oma/group/A0A0G2K470/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q62469-1", "protein_name": "Integrin alpha-2", "gene_name": "Itga2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGPGQAGGALLLRLLMLVQGILNCLAYNVGLPGAKIFSGPSSEQFGYSVQQLTNPQGNWLLVGSPWSGFPENRMGDVYKCPVDLPTATCEKLNLQNSASISNVTEIKTNMSLGLTLTRNPGTGGFLTCGPLWAHQCGNQYYATGICSDVSPDFQFLTSFSPAVQACPSLVDVVVVCDESNSIYPWEAVKNFLVKFVTGLDIGPKKTQVALIQYANEPRIIFNLNDFETKEDMVQATSETRQHGGDLTNTFRAIEFARDYAYSQTSGGRPGATKVMVVVTDGESHDGSKLKTVIQQCNDDEILRFGIAVLGYLNRNALDTKNLIKEIKAIASTPTERYFFNVADEAALLEKAGTLGEQIFSIEGTVQGGDNFQMEMAQVGFSADYAPQNDILMLGAVGAFDWSGTLVQETSHKPVIFPKQAFDQVLQDRNHSSFLGYSVAAISTEDGVHFVAGAPRANYTGQIVLYSVNKQGNVTVIQSHRGDQIGSYFGSVLCSVDVDKDTITDVLLVGAPTYMNDLKKEEGKVYLFTITKGILNQHQFLEGPEGTGNARFGSAIAALSDINMDGFNDVIVGSPVENENSGAVYIYNGHQGTIRTKYSQKILGSNGAFRRHLQFFGRSLDGYGDLNGDSITDVSIGALGQVIQLWSQSIADVAIEALFTPDKITLLNKDAKITLKLCFRAEFRPAGQNNQVAILFNMTLDADGHSSRVTSRGVFRENSERFLQKNMVVNEVQKCSEHHISIQKPSDVVNPLDLRVDISLENPGTSPALEAYSETVKVFSIPFYKECGSDGICISDLILDVQQLPAIQTQSFIVSNQNKRLTFSVILKNRGESAYNTVVLAEFSENLFFASFSMPVDGTEVTCEVGSSQKSVTCDVGYPALKSEQQVTFTINFDFNLQNLQNQAAINFQAFSESQETNKADNSVSLTIPLLYDAELHLTRSTNINFYEISSDENAPSVIKSVEDIGPKFIFSLKVTAGSAPVSMALVTIHIPQYTKEKNPLLYLTGIQTDQAGDISCTAEINPLKLPHTAPSVSFKNENFRHTKELDCRTTSCSNITCWLKDLHMKAEYFINVTTRVWNRTFAASTFQTVQLTAAAEIDTHNPQLFVIEENAVTIPLMIMKPTEKAEVPTGVIIGSIIAGILLLLAMTAGLWKLGFFKRQYKKMGQNPDEMDETTELNS", "length": 1178 }, "evidence": [ { "id": "47569005", "url": "http://www.informatics.jax.org/homology/47569005", "database": "MGI" }, { "id": "A0A0G2K470", "url": "https://omabrowser.org/oma/group/A0A0G2K470/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 8, "go_terms": [ { "name": "integrin binding", "id": "GO:0005178", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005178", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K470", "url": "https://www.uniprot.org/uniprot/A0A0G2K470" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K470", "url": "https://www.uniprot.org/uniprot/A0A0G2K470" } ], "pmid": "" }, { "name": "amyloid-beta binding", "id": "GO:0001540", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001540", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K470", "url": "https://www.uniprot.org/uniprot/A0A0G2K470" } ], "pmid": "" }, { "name": "collagen binding", "id": "GO:0005518", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005518", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K470", "url": "https://www.uniprot.org/uniprot/A0A0G2K470" } ], "pmid": "" }, { "name": "laminin binding", "id": "GO:0043236", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043236", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K470", "url": "https://www.uniprot.org/uniprot/A0A0G2K470" } ], "pmid": "" }, { "name": "protein-containing complex binding", "id": "GO:0044877", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044877", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K470", "url": "https://www.uniprot.org/uniprot/A0A0G2K470" } ], "pmid": "" }, { "name": "collagen receptor activity", "id": "GO:0038064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038064", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K470", "url": "https://www.uniprot.org/uniprot/A0A0G2K470" } ], "pmid": "" }, { "name": "collagen binding involved in cell-matrix adhesion", "id": "GO:0098639", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098639", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K470", "url": "https://www.uniprot.org/uniprot/A0A0G2K470" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 12, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K470", "url": "https://www.uniprot.org/uniprot/A0A0G2K470" } ], "pmid": "" }, { "name": "focal adhesion", "id": "GO:0005925", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005925", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K470", "url": "https://www.uniprot.org/uniprot/A0A0G2K470" } ], "pmid": "" }, { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K470", "url": "https://www.uniprot.org/uniprot/A0A0G2K470" } ], "pmid": "" }, { "name": "axon", "id": "GO:0030424", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030424", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K470", "url": "https://www.uniprot.org/uniprot/A0A0G2K470" } ], "pmid": "" }, { "name": "axon terminus", "id": "GO:0043679", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043679", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K470", "url": "https://www.uniprot.org/uniprot/A0A0G2K470" } ], "pmid": "" }, { "name": "basal part of cell", "id": "GO:0045178", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045178", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K470", "url": "https://www.uniprot.org/uniprot/A0A0G2K470" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K470", "url": "https://www.uniprot.org/uniprot/A0A0G2K470" } ], "pmid": "" }, { "name": "external side of plasma membrane", "id": "GO:0009897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K470", "url": "https://www.uniprot.org/uniprot/A0A0G2K470" } ], "pmid": "" }, { "name": "cell projection", "id": "GO:0042995", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042995", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K470", "url": "https://www.uniprot.org/uniprot/A0A0G2K470" } ], "pmid": "" }, { "name": "presynapse", "id": "GO:0098793", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098793", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K470", "url": "https://www.uniprot.org/uniprot/A0A0G2K470" } ], "pmid": "" }, { "name": "integrin complex", "id": "GO:0008305", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008305", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K470", "url": "https://www.uniprot.org/uniprot/A0A0G2K470" } ], "pmid": "" }, { "name": "integrin alpha2-beta1 complex", "id": "GO:0034666", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034666", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K470", "url": "https://www.uniprot.org/uniprot/A0A0G2K470" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 37, "go_terms": [ { "name": "integrin-mediated signaling pathway", "id": "GO:0007229", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007229", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K470", "url": "https://www.uniprot.org/uniprot/A0A0G2K470" } ], "pmid": "" }, { "name": "positive regulation of cell adhesion", "id": "GO:0045785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045785", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K470", "url": "https://www.uniprot.org/uniprot/A0A0G2K470" } ], "pmid": "" }, { "name": "positive regulation of smooth muscle contraction", "id": "GO:0045987", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045987", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K470", "url": "https://www.uniprot.org/uniprot/A0A0G2K470" } ], "pmid": "" }, { "name": "response to hypoxia", "id": "GO:0001666", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001666", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K470", "url": "https://www.uniprot.org/uniprot/A0A0G2K470" } ], "pmid": "" }, { "name": "response to organic cyclic compound", "id": "GO:0014070", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014070", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K470", "url": "https://www.uniprot.org/uniprot/A0A0G2K470" } ], "pmid": "" }, { "name": "cell-matrix adhesion", "id": "GO:0007160", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007160", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K470", "url": "https://www.uniprot.org/uniprot/A0A0G2K470" } ], "pmid": "" }, { "name": "cell adhesion mediated by integrin", "id": "GO:0033627", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033627", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K470", "url": "https://www.uniprot.org/uniprot/A0A0G2K470" } ], "pmid": "" }, { "name": "cell-cell adhesion", "id": "GO:0098609", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098609", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K470", "url": "https://www.uniprot.org/uniprot/A0A0G2K470" } ], "pmid": "" }, { "name": "female pregnancy", "id": "GO:0007565", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007565", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K470", "url": "https://www.uniprot.org/uniprot/A0A0G2K470" } ], "pmid": "" }, { "name": "positive regulation of collagen biosynthetic process", "id": "GO:0032967", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032967", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K470", "url": "https://www.uniprot.org/uniprot/A0A0G2K470" } ], "pmid": "" }, { "name": "positive regulation of smooth muscle cell proliferation", "id": "GO:0048661", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048661", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K470", "url": "https://www.uniprot.org/uniprot/A0A0G2K470" } ], "pmid": "" }, { "name": "positive regulation of transmission of nerve impulse", "id": "GO:0051971", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051971", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K470", "url": "https://www.uniprot.org/uniprot/A0A0G2K470" } ], "pmid": "" }, { "name": "detection of mechanical stimulus involved in sensory perception of pain", "id": "GO:0050966", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050966", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K470", "url": "https://www.uniprot.org/uniprot/A0A0G2K470" } ], "pmid": "" }, { "name": "response to muscle activity", "id": "GO:0014850", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014850", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K470", "url": "https://www.uniprot.org/uniprot/A0A0G2K470" } ], "pmid": "" }, { "name": "focal adhesion assembly", "id": "GO:0048041", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048041", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K470", "url": "https://www.uniprot.org/uniprot/A0A0G2K470" } ], "pmid": "" }, { "name": "substrate-dependent cell migration", "id": "GO:0006929", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006929", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K470", "url": "https://www.uniprot.org/uniprot/A0A0G2K470" } ], "pmid": "" }, { "name": "positive regulation of translation", "id": "GO:0045727", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045727", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K470", "url": "https://www.uniprot.org/uniprot/A0A0G2K470" } ], "pmid": "" }, { "name": "cellular response to mechanical stimulus", "id": "GO:0071260", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071260", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K470", "url": "https://www.uniprot.org/uniprot/A0A0G2K470" } ], "pmid": "" }, { "name": "positive regulation of phagocytosis, engulfment", "id": "GO:0060100", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060100", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K470", "url": "https://www.uniprot.org/uniprot/A0A0G2K470" } ], "pmid": "" }, { "name": "response to xenobiotic stimulus", "id": "GO:0009410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009410", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K470", "url": "https://www.uniprot.org/uniprot/A0A0G2K470" } ], "pmid": "" }, { "name": "cellular response to estradiol stimulus", "id": "GO:0071392", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071392", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K470", "url": "https://www.uniprot.org/uniprot/A0A0G2K470" } ], "pmid": "" }, { "name": "cellular response to organic cyclic compound", "id": "GO:0071407", "url": 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