{ "uniprot_canonical_ac": "A0A0G2K3F3-1", "uniprot_ac": "A0A0G2K3F3", "uniprot_id": "A0A0G2K3F3_RAT", "mass": { "chemical_mass": 79464.0, "monoisotopic_mass": 79464.0 }, "refseq": { "ac": "XP_008759462", "name": "DC-STAMP domain containing 2 isoform 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_008759462" }, "gene_names": [ { "name": "Dcst2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A0G2K3F3", "id": "A0A0G2K3F3" }, { "name": "Dcst2-ps1; RGD1564557", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_008759462", "id": "XP_008759462" }, { "name": "Dcst2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_008759462", "id": "XP_008759462" } ], "protein_names": [ { "name": "DC-STAMP domain containing 2 isoform 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_008759462", "id": "XP_008759462" }, { "name": "DC-STAMP domain containing 2, pseudogene 1; DC-STAMP domain-containing protein 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_008759462", "id": "XP_008759462" }, { "name": "DC-STAMP domain containing 2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K3F3/entry#names_and_taxonomy", "id": "A0A0G2K3F3" } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K3F3", "url": "https://www.uniprot.org/uniprot/A0A0G2K3F3" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "gene": [ { "name": "Dcst2", "url": "https://www.uniprot.org/uniprot/A0A0G2K3F3", "locus": { "chromosome": "2", "start_pos": 174795832, "end_pos": 174781902, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000058618", "url": "https://www.ensembl.org/id/ENSRNOG00000058618" } ] } } ], "crossref": [ { "id": "A0A0G2K3F3", "url": "https://alphafold.ebi.ac.uk/entry/A0A0G2K3F3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSRNOG00000058618", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000058618", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "295247", "url": "https://www.ncbi.nlm.nih.gov/gene/295247", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR012858", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012858", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051856", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051856", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "DDAKDNC", "url": "https://omabrowser.org/oma/group/DDAKDNC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A0G2K3F3", "url": "https://www.orthodb.org/?gene=A0A0G2K3F3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21041", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21041", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21041:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21041:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07782", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07782", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "XP_008759462", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_008759462", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "1564557", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1564557", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "A0A0G2K3F3", "url": "https://www.uniprot.org/uniprot/A0A0G2K3F3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2K3F3-1", "url": "https://www.uniprot.org/uniprot/A0A0G2K3F3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVKTDIEWPSGEEKSSMARAVVRSTCGFTLGLSLATAYGLLELLAEGHSPFGCLVTTVTLAAFLGLGMGFSRQVRVSVFLLLPQVFSKQSRLLLLVAAFGLVLQGPCANTLRNFTRASEAVACGAELALNQTAEVLERVKQPLVSALTKIKAIAQKAKVVADRVRKFFRSVMDGVKHVARCLQNMWYWLLHIGDVCNSELGNPYTKCARVFDDAKDNCMKVVPRFHQLCYVLLPFKLVFCGLANLVQLFCVIPMYLQQFLRKTIKTPVMKLLDRVRREFEFNMTATHYFSVDLNASRSLSQVALDLHEAVSMKLYTAREVLSMMGYTMPLLFGLLYIQALYYRYGYLNWDNFDNVYITRRFLDMEAVRSLAGLRTVLPLSSHEARHYVQPGSFFLTRWEQILYIVETFNLARHLLLVLLLVFLDYGVFWILDLARYHLQGEIVARSPVLVSIKVEGTGYSGNIYRDLVSAFDVLQQGNVSILSRRCALRPSEPDANGYIVIGTMYGLCFFVTLFGSYVSRLRRVICASYYPSREQERITYLYNMLLSRRTNIPAAVQRAVRRRAADQGHMSILQVLATRYPSLSPLLGRFLLHQTYCLGCGQPEEKGGMENFVSCSTPGCRGLYCPTCFRLLDNTCSVCASPLSNQGRLDLELDSSDEEGPQLWLAAARRRAPEQELELRQQLQEALGTNLSEEPGSQPESRKQ", "length": 704, "header": "tr|A0A0G2K3F3-1|A0A0G2K3F3_RAT Isoform 1 of DC-STAMP domain containing 2 OS=Rattus norvegicus OX=10116 GN=Dcst2 PE=4 SV=1 CANONICAL=A0A0G2K3F3-1" }, "isoforms": [ { "isoform_ac": "A0A0G2K3F3-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K3F3/entry#A0A0G2K3F3-1", "sequence": { "sequence": "MVKTDIEWPSGEEKSSMARAVVRSTCGFTLGLSLATAYGLLELLAEGHSPFGCLVTTVTLAAFLGLGMGFSRQVRVSVFLLLPQVFSKQSRLLLLVAAFGLVLQGPCANTLRNFTRASEAVACGAELALNQTAEVLERVKQPLVSALTKIKAIAQKAKVVADRVRKFFRSVMDGVKHVARCLQNMWYWLLHIGDVCNSELGNPYTKCARVFDDAKDNCMKVVPRFHQLCYVLLPFKLVFCGLANLVQLFCVIPMYLQQFLRKTIKTPVMKLLDRVRREFEFNMTATHYFSVDLNASRSLSQVALDLHEAVSMKLYTAREVLSMMGYTMPLLFGLLYIQALYYRYGYLNWDNFDNVYITRRFLDMEAVRSLAGLRTVLPLSSHEARHYVQPGSFFLTRWEQILYIVETFNLARHLLLVLLLVFLDYGVFWILDLARYHLQGEIVARSPVLVSIKVEGTGYSGNIYRDLVSAFDVLQQGNVSILSRRCALRPSEPDANGYIVIGTMYGLCFFVTLFGSYVSRLRRVICASYYPSREQERITYLYNMLLSRRTNIPAAVQRAVRRRAADQGHMSILQVLATRYPSLSPLLGRFLLHQTYCLGCGQPEEKGGMENFVSCSTPGCRGLYCPTCFRLLDNTCSVCASPLSNQGRLDLELDSSDEEGPQLWLAAARRRAPEQELELRQQLQEALGTNLSEEPGSQPESRKQ", "length": 704, "header": "tr|A0A0G2K3F3-1|A0A0G2K3F3_RAT Isoform 1 of DC-STAMP domain containing 2 OS=Rattus norvegicus OX=10116 GN=Dcst2 PE=4 SV=1 CANONICAL=A0A0G2K3F3-1" }, "locus": { "chromosome": "2", "start_pos": 174791613, "end_pos": 174781946, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000081189.2", "url": "https://www.ensembl.org/id/ENSRNOT00000081189.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000072613.1", "url": "https://www.ensembl.org/id/ENSRNOP00000072613.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool": "isoglyp", "mining_tool": "", "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "start_pos": 617, "start_aa": "T", "end_pos": 617, "end_aa": "T", "residue": "Thr", "site_lbl": "Thr617", "evidence": [ { "id": "GLY_001157", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001157" } ], "filter_code": "00000000000000001000.00000000001000.1.01000" } ], "phosphorylation": [ { "start_pos": 540, "end_pos": 540, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "A0A0G2K3F3", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A0A0G2K3F3" } ], "site_lbl": "Tyr540" }, { "start_pos": 542, "end_pos": 542, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "A0A0G2K3F3", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A0A0G2K3F3" } ], "site_lbl": "Tyr542" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A140LIJ0-1", "protein_name": "DC-STAMP domain-containing protein 2", "gene_name": "Dcst2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEEGSSTARAVVRSTCGFTVGLSLATAFGLLELLGEGHSPFGCLVTTVTLAAFLSLGMGFSRQVRVSVLLLLPQAFSKQSRLLLLVASFGLVLQGPCANTLQNFTRASEAVACGAELALNQTAEMLERAKQPLISALSKIKAIAQKAKVVGDRIRKFFRSIIDAVKHIARCLQNVWYWLLHIGDMCNSELGNPYSKCTQVFDDAKIHCMKVVSGFPHLCYALLPYKLLVCGLASLVQKFCVLPSYLEFFLRTVIRTPVMKLLGKLRREFEFNMTATHYFSVDLNSSRSLSQVALDLQEAVSMKLYTAREALSLMGYTMPLLIGFLYIQALCYRYYYLNSDKFDNVYITRRFLDMEAVRSLAGMPTVLPLSSHEAKHYIQPDSMFLSQREQMFYTLEIFNLTRHLLIMLLLVFLDYGVFWLLDLARYHLQGEIVARSPVVVSISVEGSGYSGNIYRDLASAFDVMQQGNVSVLSPRCTLHPSEPDAKGYIVIGTMYGLCFFVTLFGSYVSRLRRAICASYYPSREQERITYLYNMLLSHRTNITATVQRAVRRRSADQGQMNILQVLAIRLPFLRPLLGPFSLQQSYCMGCGEPEDKGGMENFVSCSTPGCRGLYCPTCFRLLNNTCSVCSAPLSNQGHLDLELDSSDEESPQLWLAAARRKAPEQELKLRQQLQEALGTNLSDKSTSKPERAGNRNQDRKQ", "length": 701 }, "evidence": [ { "id": "A0A0G2K3F3", "url": "https://omabrowser.org/oma/group/A0A0G2K3F3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q5T1A1-1", "protein_name": "DC-STAMP domain-containing protein 2", "gene_name": "DCST2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPKVMKDVVHPLGGEEPSMARAVVRSVGGFTLGLSLATAYGLLELLVEGHSPWGCLVGTLTLAAFLSLGMGFSRQVRATVLLLLPQAFSRQGRTLLLVAAFGLVLQGPCANTLRNFTRASEAVACGAELALNQTAEVLQRAKQPLVSALNKIKAIARKTKEVADRVRKFFRSIMDGVKHIARALRNVWQWLLHIGDVCNSELGNPYLKCARVFDDAKDSCMMVIPQAYHLCYVLMPFKLALCGLASLVQVFCVIPKYIQPFLRQTIGTPVIQLLNRVRQEFEFNMTATHHFSVDLNASRSLSQVAMDLHEAVSMKLHRVREALALMGFTTPLLLVLLYLQALFYRYCYLNWDHYDNIYITSRFLRMEAVRSTAGLPTVLPLSAHEARRYIPPGSIFLSQWEKFFYILETFNLIRHLLLVLFLVFLDYAVFWVLDLARHQLQGEIVARSPVLVSLTVEGTGYAGNIYRDLVSAFDVLQQGNISILSRRCLLRPSEPDSTGYIVIGVMYGLCFFITLFGSYVSRLRRVICASYYPSREQERISYLYNVLLSRRTNLLAALHRSVRRRAADQGHRSAFLVLASRCPCLGPFVSHFWLHQAYCLGCGQPQDEGDMENTVSCSTPGCQGLYCLTCFRLLDNTCSVCASPLSYQGDLDLELDSSDEEGPQLWLAAAQRKDPEQAWLLQQQLQEVLGRSLSMESTSESSDLDEEKGPQQRKHGQQPLPEAHQPVSILTSPEPHRPPETSSATKGAPTPASEPSVPLSPPSLPDPSHPPPK", "length": 773 }, "evidence": [ { "id": "47567588", "url": "http://www.informatics.jax.org/homology/47567588", "database": "MGI" }, { "id": "A0A0G2K3F3", "url": "https://omabrowser.org/oma/group/A0A0G2K3F3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9W0V0-1", "protein_name": "Uncharacterized protein, isoform C", "gene_name": "Dmel\\CG6845", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MEESQPRYGAMWTFKLVAPYVIGGYLCGLAVTLAWNWWQLGHLVLGLNLTFAIPVALVLAVFYSRPVRCIVTLALPSLCSSRGRAFLISLAFVIAAVGPTANILANLKVMLRSLACGQELLRQALGQMLDVILEPVNAIQLAVDLLMREVRRVLKLAMVVLLRIQDQLIAIIKTLKNCAAWLKSIVDLCNTEMGTPWARCKKTAHHAMIRCQSKMGVFKALCHAAKLFLALCYPAKIIDVFCSGYWDLSWGLLDKIAERYREFVRHIEEMFDANITFEHEFFFDTNSSKSLTDVGEEILQDINKRLSSFIFLSSFVDILCWVMVVTVFFKATIFYLRYMHSRQFQNVFLTKILSDIDRRHEKHGYDPLLPLHQLERAKYMKLTSLRLTLFEFVSIVENACFMATTCLQLFAICFLDYGLFWLLATISLHGHQETGLEVPAYVDLEIKGGGFVADVMRGIANAFRPLTQKSILDVNPCLPLPVKPDYAEYLIILLLCLLAWLILLAEPYILRTRHLIMAHFYPKRAKERGMFLYNMISEDRTSIFKFIRRRKRNEFNHTRNVKHTRNYTWLNNRFSCLMCMCSCCSSCQSTERCTICGRSLTLSNRNPCDTPGCKGVYCGKCFEKSHNKCCLCNRPVDYGDFSDVTEVDDSSDYSEKESFSERQYRKTCGGQR", "length": 672 }, "evidence": [ { "id": "A0A0G2K3F3", "url": "https://omabrowser.org/oma/group/A0A0G2K3F3/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "sperm-egg recognition", "id": "GO:0035036", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035036", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K3F3", "url": "https://www.uniprot.org/uniprot/A0A0G2K3F3" } ], "pmid": "" }, { "name": "fusion of sperm to egg plasma membrane involved in single fertilization", "id": "GO:0007342", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007342", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K3F3", "url": "https://www.uniprot.org/uniprot/A0A0G2K3F3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K3F3", "url": "https://www.uniprot.org/uniprot/A0A0G2K3F3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 113, "end_pos": 115, "annotation": "n_glycosylation_sequon" }, { "start_pos": 130, "end_pos": 132, "annotation": "n_glycosylation_sequon" }, { "start_pos": 282, "end_pos": 284, "annotation": "n_glycosylation_sequon" }, { "start_pos": 294, "end_pos": 296, "annotation": "n_glycosylation_sequon" }, { "start_pos": 478, "end_pos": 480, "annotation": "n_glycosylation_sequon" }, { "start_pos": 690, "end_pos": 692, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A0G2K3F3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 704, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A0G2K3F3-F1.pdb" } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 617 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 540, 542 ], "sequon_annotation_sites": [ { "start_pos": 113, "end_pos": 115 }, { "start_pos": 130, "end_pos": 132 }, { "start_pos": 282, "end_pos": 284 }, { "start_pos": 294, "end_pos": 296 }, { "start_pos": 478, "end_pos": 480 }, { "start_pos": 690, "end_pos": 692 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "prediction_tool", "mining_tool", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { 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[] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }