{ "uniprot_canonical_ac": "A0A0G2K2W1-1", "uniprot_ac": "A0A0G2K2W1", "uniprot_id": "A0A0G2K2W1_RAT", "mass": { "chemical_mass": 444289.0, "monoisotopic_mass": 444289.0 }, "refseq": {}, "gene_names": [ { "name": "Pkhd1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A0G2K2W1", "id": "A0A0G2K2W1" } ], "protein_names": [ { "name": "PKHD1 ciliary IPT domain containing fibrocystin/polyductin", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2W1/entry#names_and_taxonomy", "id": "A0A0G2K2W1" } ], "function": [], "disease": [ { "disease_id": "DOID:0080212", "recommended_name": { "id": "DOID:0080212", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080212", "name": "polycystic kidney disease 4", "description": "A autosomal recessive polycystic kidney disease that has_material_basis_in mutation in the PKD4 gene." }, "synonyms": [], "evidence": [ { "id": "0080212", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0080212" } ] }, { "disease_id": "DOID:0081394", "recommended_name": { "id": "DOID:0081394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0081394", "name": "Caroli syndrome", "description": "A syndrome that is characterized by the presence of associated congenital hepatic fibrosis and that is associated with autosomal recessive polycystic kidney disease." }, "synonyms": [], "evidence": [ { "id": "0081394", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0081394" } ] }, { "disease_id": "DOID:0110861", "recommended_name": { "id": "DOID:0110861", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110861", "name": "autosomal recessive polycystic kidney disease", "description": "A polycystic kidney disease characterized by the presence of multiple cysts located_in the kidney resulting from ciliopathy that disrupts the function of primary cilium, inherited in an autosomal recessive fashion." }, "synonyms": [ { "id": "DOID:0110861", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110861", "name": "Arpkd", "description": "" }, { "id": "DOID:0110861", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110861", "name": "Pkhd1", "description": "" }, { "id": "DOID:0110861", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110861", "name": "Polycystic Kidney Disease, Infantile, Type I", "description": "" }, { "id": "DOID:0110861", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110861", "name": "Polycystic Kidney and Hepatic Disease 1", "description": "" }, { "id": "MONDO:0033004", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0033004", "name": "polycystic kidney disease 4", "description": "A autosomal dominant polycystic kidney disease that has material basis in mutation in the PKD4 gene." }, { "id": "MONDO:0033004", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0033004", "name": "polycystic kidney disease 4", "description": "" }, { "id": "MONDO:0033004", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0033004", "name": "polycystic kidney disease 4, with or without hepatic disease", "description": "" }, { "id": "MONDO:0033004", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0033004", "name": "PKD3", "description": "" }, { "id": "MONDO:0033004", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0033004", "name": "PKD3, formerly", "description": "" }, { "id": "MONDO:0033004", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0033004", "name": "PKD4", "description": "" }, { "id": "MONDO:0033004", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0033004", "name": "hepatic fibrosis, congenital", "description": "" }, { "id": "MONDO:0033004", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0033004", "name": "polycystic kidney and hepatic disease 1", "description": "" }, { "id": "MONDO:0033004", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0033004", "name": "polycystic kidney disease 4 with or without hepatic disease", "description": "" }, { "id": "MONDO:0033004", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0033004", "name": "polycystic kidney disease 4 with or without polycystic liver disease", "description": "" }, { "id": "MONDO:0033004", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0033004", "name": "polycystic kidney disease, autosomal recessive", "description": "" }, { "id": "MONDO:0033004", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0033004", "name": "polycystic kidney disease, infantile, type 1", "description": "" }, { "id": "MIM:263200", "resource": "MIM", "url": "https://www.omim.org/entry/263200", "name": "Polycystic kidney disease 4, with or without polycystic liver disease", "description": "Polycystic kidney disease 4, with or without polycystic liver disease" } ], "evidence": [ { "id": "0110861", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0110861" } ] } ], "snv": [ { "evidence": [ { "id": "rs106508406", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs106508406" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 965, "end_pos": 965, "sequence_org": "I", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (INT->NNT).", "chr_id": "9", "chr_pos": "22982023", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "I965", "keywords": [ "ebi", "germline" ] } ], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2W1", "url": "https://www.uniprot.org/uniprot/A0A0G2K2W1" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "gene": [ { "name": "Pkhd1", "url": "https://www.uniprot.org/uniprot/A0A0G2K2W1", "locus": { "chromosome": "9", "start_pos": 22549513, "end_pos": 23037381, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000058742", "url": "https://www.ensembl.org/id/ENSRNOG00000058742" } ] } } ], "crossref": [ { "id": "A0A0G2K2W1", "url": "https://alphafold.ebi.ac.uk/entry/A0A0G2K2W1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSRNOG00000058742", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000058742", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00603", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00603", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR002909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006626", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006626", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011050", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011050", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012334", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012334", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014756", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014756", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019316", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019316", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037524", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037524", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039448", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039448", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052387", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052387", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "QSCAINV", "url": "https://omabrowser.org/oma/group/QSCAINV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR46769", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46769", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46769:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46769:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01833", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01833", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF10162", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10162", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF13229", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13229", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "1308476", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1308476", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "A0A0G2K2W1", "url": "https://www.uniprot.org/uniprot/A0A0G2K2W1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2K2W1-1", "url": "https://www.uniprot.org/uniprot/A0A0G2K2W1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "VMPAWRISLLSVELLLLANAYSSFRIEPTEGSLAGGTWITLVFDGLETSILYPNNGSQLAIDLVNVATPALKIPCDISPLFVDLPVVTCQTRSLPSEAPEGLYSLEIRSGDQLLGSPCARLLDNCTFKFSKEQTPVLYQVNPSSGVPGEVVHVYGWVITDRMEIFDPDVDYMESPLILEAGGDKWLTPCSLINRKTGICFPIQEEHGLGTVQCRVEGSYIGSQNVSFSVFNKGRSMVHKEAWLISAKQELFLYQTYPEIHSVFPKVGSLGGRTDITITGDFFDPSARVTIAGIPCDIRHVSPRKIECTTRAPGNGARLTAPQAGNRGLLFEVGNAVKDEELTEATPGYRWQIVPNASSPSGFWSKEGRPFRARLSGFFVAPETNNYTFWIQADSQAFLRFSSSEEPRMKVEVASIAVGTADWFDSWEQNGNEGSWQQKTNKLELQGGAKYYLEAEQHGIAPSRGMRIAVQIHNTWLNPDVVNTYLLEKHQIRAQAQRLPEIQVLNMSGKGNFFLTWGNVSSQPVPANATAQQIQTIIEELLVVKCNLVPLSARVLLWLGFEQGLDGSRSDGVLTSSTEPFCGRFSLGQLRHLILSPGAVSKGYQLDRYPYLCFAYRGHMNRTLDMTVSFLFGFQNVMKNITCDWSLMEPHPESWHFTCNNLWDTCVRHSEELQSSLANTPLLVHRIDIFPVVPEADLLYVDEIILADTNVTVSQADSGVARPGGNVVESVSVVGVPPVYSIASWMAGCGSELPLITACYVPTQGTGEGSELIEVTAKRLQRTSPPLGGHFSLHLSDTVIPDVPVHVSARQLHKLLQDNADESTSGYLNADDFIVTKDQNSCYEHVWTLSWTTQIGDLPNFIRVSDQNLTGLNPTITARVVYDGGVFLGPILGDTLATANQQTQVTVQVNDIPAHCSGSCSFQYQRASTPSVDCVWYSLGSDVNLLVHFTGNGFPRDAQFLQVTVINTSCEVIFSNETNVACELALLPVGVHRVFMLVRPSGLALNASGEGLFLRVEPRLDAVEPSTGAEIGGWWVTLRGSSLEGVSLVLFGTRSCVIDVIRSNSQQIQCKVPPRGKDGYTVNVTVINGDHSTVLARAFTYVSSLNPVIVSLSRNRSNIAGGEILFLGMTLMVNYTDLNVQIYIQNTSAQVLAKTAWGLEVLLPPLLPGIYVISAFINGISIRSQGVDLHIQYLTEVFSMEPCSGSLLGGTILRLSGAGLGRDPALIRVLVDNRPCDTVKLTEVNIWCETPRVLLPPRADVLTVPASVEIWAGNTSFVGKAFIFTYEAAATPVVTAMWGELMNNSVRFYVEGNNLSDSVILLGSLKCDLQVQLFGDNMNLSGCSLLLHSLEAGVYALQVRHKRMGFANMSAVPQKFELSPQIIDIFPTHGSIYGGTVLTVKGTAFRSRRRSVHVDLSGPFTCVILSLGDHTVLCQTKFVGDQFSETSLALNITVLVNGLTSKCEGNCTLFLEEAATPIVDALTISISGSLTTVLMRGQRLGSAGEPTAFVDGQLLCHTTFFNTSYVACQMRDLAPGFHYLSAVRTSAGYACLNSVSRNFFVVPQVFDYFPKDFSIHGGSLLTIKGTTLRGWKTTFVYVGQQACLTVNISSEFIQCIVPAGNGSAALEIDVDGVLYHMGFVDYSSIFTPELLSVSRSHDILTFTVARISGAANVDILIGTSPCLDVAGNRTILRCMVPLLPAGEYAVTGYDHSRGWVSSTLILVLRATVTSVTENYGCLGGRLLHVLGAGFSPGNISAAVCGAPCQVLANATVSAFSCLVLPLDASLAFLCNLRHAEDSCGVSRPTYLQCDLTVSVGMERLPGSWPYVYLCEESSQGLFVPDHQIFLSFSGLFLSPKVERDEVLIYNSSCNITMETEAEMECGTPNQPITAKITEIQKSRGQNTQGNFSFQFCRRWSRPHSWFPHRVPQDGDNVTVETSHLLLLDANTSLLNSLHIKGGKLIFMEPGPIDLRAHSILITDGGELHIGSEDKPFQGKARIKLYGSVHSTSFFPYGVKFLAVRNGTLSLHGSVPEVTFTYLRAAACAGDTVLALEEAVAWHPGDEAVISSGATVEGAEATEEVVVVETVHDADLHLRNPLRYSYNFTENWVTGVNHILKATVALLSRNIIVQGNLTLERVKLLDSCQEAGAAEGNLKHCLYSKSEKMLGARNLGARVIIQSFPEEPSLVKLKGVQFRDLGQAFHKHLSSLTLVGAMRGSYLHSCSMWGSFSRGLSIHRTWGLKVENNIFYKIVGHALLVGSYMDRSFSTSEAVIGRKNGWWEEGSMIRNNVIINVSGAEGLSSSEMLAPAGIYTFSPTSAIEGNRVCAAGYGYVLHLVTSQTVQAPLLSFNWNTAHSCTRYGLLVYPEFQPPWNNDTGFTLFQNFMVWGSAGGAQIFRSNNLHLRNFQVYACRDFGIDILESDTNTLVTDSFLLGHFTHEGSLCMSVGIKTPKRWGLTISNTTFVNFDLNCVAIRTCSGCSQGQGGFPVKTRQLKFVNSSNLVAFPFPHAAVLQDLDGSLSGKNGSHVLASMETLSDTCLTNASFSQIVSGSVCGEAVLFHRMSIGLAKSLDVPKNLTMTDIRNRTITINYVDDTLSNSYGWMALLLDQETYLLQFEGPWTDGSLQYSATFDNFAPGNYLLLMHRDLLPYPDILLRCGSRVGQSLPSHPLPSRDGACDWFFHRQLRQLTYLVSGEGQVHVFLQVKHGAPPTVSASTSVSESALKWSLPETWQDVEKGWGGYNHTIPGPGDDVLILPNKTVLVDTDLPVLRCLYVMGTLEFPVDRSNVLSVACLLIAGGELKVGTLENPLGKDQRLLILLRASEEIFCDRFDGIRVDPGTIGVYGKLRLHSAYPKKSWVHLGADIAPGNERIIVHNAVDWQPHDKIVLSSSSYEPHEAEVLTVKEVKDHHIRIYERLKHRHIGSAHTLEDSRQICLAAEVGLLTRNIRIQSDSSCRGRLLVGSFRKSSGEEFSGILQLLNVEIQNMGSPLYASIEFTGVSAGSWVISSTVHQSCTVGIHASSSRGMVLNDNIVFGTKGHGIDVEGQNYSLTNNLVILSMQSANSLPWVAGIKVNYAEDIILHGNVVAGSERLGFHVRGHGCSSEVLWSDNVVHSSLHGIHLYKKREPNNCTGVSGFLAFKNFDYGAMVQTENSVDIQNITLVDNTVGLLAISYVSSAPLRSGSTLQITLRNSVIVATSSSFDCIQDRKAPQSANWTSTDRAPSNPRGGRIGILWPVSASEPNGWPQEPWHKVRGGHSVPGIMKLQDVTFSSFVKSCYSDDLDVCILTNEHSTGIMYPITAERTRMLKIKDKNKFYFLPLQSGKDLVGTICPASSDCEIPRKYLFTDLDGRTLGLSPPVSVFPRIEEGWTGSFFNTGIFREEQKCTFRAMIQGFFCKQTEHAVLILDNVDVTWTIPKFYPLVSITNGFVDTFSIVKDSGLCFPTSSPSTFYSILPTRQMTKVCFPERTPPFLHFFLLANRRASKLILAVFYNEIQSPYVFLDKSFIPPTPVESAFSLLDEPVGANYFDIMNNLLYVVLQGEEAVEIRSSVSIHLALTVTFSVLEKGWEKAVLESLRGFFQIDQNQIRLTLEMPGNKETLKAIANSEGKRKRSCPTVTCAVPSSRYVQRRPLMAEMASFTITPATTLETFSKVIVFEIGDLPNARDSEFIQSLPSNRLQKLAHQVITAQQTGVLENVLGMTVGALLVAQSEGVTGYRNASSLITGNQIYTRPSVVSILVQPSDGEVGIELPIQPRLIFLDEKNERVEALGLPSEPWIISVSLEGTSESMLKGCTQAETQDGYVTFSRLAVLTSGSNWHLVFTVTFPPGTNLTARSKTFAVLPVAGKERSTIILALSLCSVASWVALSCLICCWFKKSKTRKIKPEDISESQAKEQKKNTHISSKPRELQVKTAKEDAMMGEDMRMKVMEGRQNQFSQHSMDGVSKRKVSRRAVPEERTATPALKIPRTTCVPGALPQQLTLPEPGNWQEAQQQLLRYQLAGRDQLLLLCPDLRQERQQGQEPSQLNKGSGRCMGLSQEKATCVPTETFCLHTAPPETIQ", "length": 4052, "header": "tr|A0A0G2K2W1-1|A0A0G2K2W1_RAT Isoform 1 of PKHD1 ciliary IPT domain containing fibrocystin/polyductin OS=Rattus norvegicus OX=10116 GN=Pkhd1 PE=1 SV=2 CANONICAL=A0A0G2K2W1-1" }, "isoforms": [ { "isoform_ac": "A0A0G2K2W1-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2W1/entry#A0A0G2K2W1-1", "sequence": { "sequence": "VMPAWRISLLSVELLLLANAYSSFRIEPTEGSLAGGTWITLVFDGLETSILYPNNGSQLAIDLVNVATPALKIPCDISPLFVDLPVVTCQTRSLPSEAPEGLYSLEIRSGDQLLGSPCARLLDNCTFKFSKEQTPVLYQVNPSSGVPGEVVHVYGWVITDRMEIFDPDVDYMESPLILEAGGDKWLTPCSLINRKTGICFPIQEEHGLGTVQCRVEGSYIGSQNVSFSVFNKGRSMVHKEAWLISAKQELFLYQTYPEIHSVFPKVGSLGGRTDITITGDFFDPSARVTIAGIPCDIRHVSPRKIECTTRAPGNGARLTAPQAGNRGLLFEVGNAVKDEELTEATPGYRWQIVPNASSPSGFWSKEGRPFRARLSGFFVAPETNNYTFWIQADSQAFLRFSSSEEPRMKVEVASIAVGTADWFDSWEQNGNEGSWQQKTNKLELQGGAKYYLEAEQHGIAPSRGMRIAVQIHNTWLNPDVVNTYLLEKHQIRAQAQRLPEIQVLNMSGKGNFFLTWGNVSSQPVPANATAQQIQTIIEELLVVKCNLVPLSARVLLWLGFEQGLDGSRSDGVLTSSTEPFCGRFSLGQLRHLILSPGAVSKGYQLDRYPYLCFAYRGHMNRTLDMTVSFLFGFQNVMKNITCDWSLMEPHPESWHFTCNNLWDTCVRHSEELQSSLANTPLLVHRIDIFPVVPEADLLYVDEIILADTNVTVSQADSGVARPGGNVVESVSVVGVPPVYSIASWMAGCGSELPLITACYVPTQGTGEGSELIEVTAKRLQRTSPPLGGHFSLHLSDTVIPDVPVHVSARQLHKLLQDNADESTSGYLNADDFIVTKDQNSCYEHVWTLSWTTQIGDLPNFIRVSDQNLTGLNPTITARVVYDGGVFLGPILGDTLATANQQTQVTVQVNDIPAHCSGSCSFQYQRASTPSVDCVWYSLGSDVNLLVHFTGNGFPRDAQFLQVTVINTSCEVIFSNETNVACELALLPVGVHRVFMLVRPSGLALNASGEGLFLRVEPRLDAVEPSTGAEIGGWWVTLRGSSLEGVSLVLFGTRSCVIDVIRSNSQQIQCKVPPRGKDGYTVNVTVINGDHSTVLARAFTYVSSLNPVIVSLSRNRSNIAGGEILFLGMTLMVNYTDLNVQIYIQNTSAQVLAKTAWGLEVLLPPLLPGIYVISAFINGISIRSQGVDLHIQYLTEVFSMEPCSGSLLGGTILRLSGAGLGRDPALIRVLVDNRPCDTVKLTEVNIWCETPRVLLPPRADVLTVPASVEIWAGNTSFVGKAFIFTYEAAATPVVTAMWGELMNNSVRFYVEGNNLSDSVILLGSLKCDLQVQLFGDNMNLSGCSLLLHSLEAGVYALQVRHKRMGFANMSAVPQKFELSPQIIDIFPTHGSIYGGTVLTVKGTAFRSRRRSVHVDLSGPFTCVILSLGDHTVLCQTKFVGDQFSETSLALNITVLVNGLTSKCEGNCTLFLEEAATPIVDALTISISGSLTTVLMRGQRLGSAGEPTAFVDGQLLCHTTFFNTSYVACQMRDLAPGFHYLSAVRTSAGYACLNSVSRNFFVVPQVFDYFPKDFSIHGGSLLTIKGTTLRGWKTTFVYVGQQACLTVNISSEFIQCIVPAGNGSAALEIDVDGVLYHMGFVDYSSIFTPELLSVSRSHDILTFTVARISGAANVDILIGTSPCLDVAGNRTILRCMVPLLPAGEYAVTGYDHSRGWVSSTLILVLRATVTSVTENYGCLGGRLLHVLGAGFSPGNISAAVCGAPCQVLANATVSAFSCLVLPLDASLAFLCNLRHAEDSCGVSRPTYLQCDLTVSVGMERLPGSWPYVYLCEESSQGLFVPDHQIFLSFSGLFLSPKVERDEVLIYNSSCNITMETEAEMECGTPNQPITAKITEIQKSRGQNTQGNFSFQFCRRWSRPHSWFPHRVPQDGDNVTVETSHLLLLDANTSLLNSLHIKGGKLIFMEPGPIDLRAHSILITDGGELHIGSEDKPFQGKARIKLYGSVHSTSFFPYGVKFLAVRNGTLSLHGSVPEVTFTYLRAAACAGDTVLALEEAVAWHPGDEAVISSGATVEGAEATEEVVVVETVHDADLHLRNPLRYSYNFTENWVTGVNHILKATVALLSRNIIVQGNLTLERVKLLDSCQEAGAAEGNLKHCLYSKSEKMLGARNLGARVIIQSFPEEPSLVKLKGVQFRDLGQAFHKHLSSLTLVGAMRGSYLHSCSMWGSFSRGLSIHRTWGLKVENNIFYKIVGHALLVGSYMDRSFSTSEAVIGRKNGWWEEGSMIRNNVIINVSGAEGLSSSEMLAPAGIYTFSPTSAIEGNRVCAAGYGYVLHLVTSQTVQAPLLSFNWNTAHSCTRYGLLVYPEFQPPWNNDTGFTLFQNFMVWGSAGGAQIFRSNNLHLRNFQVYACRDFGIDILESDTNTLVTDSFLLGHFTHEGSLCMSVGIKTPKRWGLTISNTTFVNFDLNCVAIRTCSGCSQGQGGFPVKTRQLKFVNSSNLVAFPFPHAAVLQDLDGSLSGKNGSHVLASMETLSDTCLTNASFSQIVSGSVCGEAVLFHRMSIGLAKSLDVPKNLTMTDIRNRTITINYVDDTLSNSYGWMALLLDQETYLLQFEGPWTDGSLQYSATFDNFAPGNYLLLMHRDLLPYPDILLRCGSRVGQSLPSHPLPSRDGACDWFFHRQLRQLTYLVSGEGQVHVFLQVKHGAPPTVSASTSVSESALKWSLPETWQDVEKGWGGYNHTIPGPGDDVLILPNKTVLVDTDLPVLRCLYVMGTLEFPVDRSNVLSVACLLIAGGELKVGTLENPLGKDQRLLILLRASEEIFCDRFDGIRVDPGTIGVYGKLRLHSAYPKKSWVHLGADIAPGNERIIVHNAVDWQPHDKIVLSSSSYEPHEAEVLTVKEVKDHHIRIYERLKHRHIGSAHTLEDSRQICLAAEVGLLTRNIRIQSDSSCRGRLLVGSFRKSSGEEFSGILQLLNVEIQNMGSPLYASIEFTGVSAGSWVISSTVHQSCTVGIHASSSRGMVLNDNIVFGTKGHGIDVEGQNYSLTNNLVILSMQSANSLPWVAGIKVNYAEDIILHGNVVAGSERLGFHVRGHGCSSEVLWSDNVVHSSLHGIHLYKKREPNNCTGVSGFLAFKNFDYGAMVQTENSVDIQNITLVDNTVGLLAISYVSSAPLRSGSTLQITLRNSVIVATSSSFDCIQDRKAPQSANWTSTDRAPSNPRGGRIGILWPVSASEPNGWPQEPWHKVRGGHSVPGIMKLQDVTFSSFVKSCYSDDLDVCILTNEHSTGIMYPITAERTRMLKIKDKNKFYFLPLQSGKDLVGTICPASSDCEIPRKYLFTDLDGRTLGLSPPVSVFPRIEEGWTGSFFNTGIFREEQKCTFRAMIQGFFCKQTEHAVLILDNVDVTWTIPKFYPLVSITNGFVDTFSIVKDSGLCFPTSSPSTFYSILPTRQMTKVCFPERTPPFLHFFLLANRRASKLILAVFYNEIQSPYVFLDKSFIPPTPVESAFSLLDEPVGANYFDIMNNLLYVVLQGEEAVEIRSSVSIHLALTVTFSVLEKGWEKAVLESLRGFFQIDQNQIRLTLEMPGNKETLKAIANSEGKRKRSCPTVTCAVPSSRYVQRRPLMAEMASFTITPATTLETFSKVIVFEIGDLPNARDSEFIQSLPSNRLQKLAHQVITAQQTGVLENVLGMTVGALLVAQSEGVTGYRNASSLITGNQIYTRPSVVSILVQPSDGEVGIELPIQPRLIFLDEKNERVEALGLPSEPWIISVSLEGTSESMLKGCTQAETQDGYVTFSRLAVLTSGSNWHLVFTVTFPPGTNLTARSKTFAVLPVAGKERSTIILALSLCSVASWVALSCLICCWFKKSKTRKIKPEDISESQAKEQKKNTHISSKPRELQVKTAKEDAMMGEDMRMKVMEGRQNQFSQHSMDGVSKRKVSRRAVPEERTATPALKIPRTTCVPGALPQQLTLPEPGNWQEAQQQLLRYQLAGRDQLLLLCPDLRQERQQGQEPSQLNKGSGRCMGLSQEKATCVPTETFCLHTAPPETIQ", "length": 4052, "header": "tr|A0A0G2K2W1-1|A0A0G2K2W1_RAT Isoform 1 of PKHD1 ciliary IPT domain containing fibrocystin/polyductin OS=Rattus norvegicus OX=10116 GN=Pkhd1 PE=1 SV=2 CANONICAL=A0A0G2K2W1-1" }, "locus": { "chromosome": "9", "start_pos": 23035484, "end_pos": 22550573, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000080948.2", "url": "https://www.ensembl.org/id/ENSRNOT00000080948.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000072399.2", "url": "https://www.ensembl.org/id/ENSRNOP00000072399.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool": "isoglyp", "mining_tool": "", "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "start_pos": 3503, "start_aa": "T", "end_pos": 3503, "end_aa": "T", "residue": "Thr", "site_lbl": "Thr3503", "evidence": [ { "id": "GLY_001157", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001157" } ], "filter_code": "00000000000000001000.00000000001000.1.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2006", "authors": "Hoffert JD, Pisitkun T, Wang G, Shen RF, Knepper MA", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2W1", "url": "https://www.uniprot.org/uniprot/A0A0G2K2W1" } ], "reference": [ { "type": "PubMed", "id": "16641100", "url": "https://glygen.org/publication/PubMed/16641100" } ] } ], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "E1BK86-1", "protein_name": "PKHD1 ciliary IPT domain containing fibrocystin/polyductin", "gene_name": "PKHD1", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "KSFWEVEILEISVPCLNIHIEPEEGSLAGGTWITVIFDGLELGLLHPANGSQLEIHLVNVALPTLPSIPCDVSPVFLDVPAVMCRTRSLLPEAQEGVYSLEVQAGGQVVGSPHPGPQDGRTFKFSRAQTPIVYKVNPPSGVPGKLIHVYGWIITGRSETFDFDAEYIDSPLILEAQGDKWITPCSLVNRQTGSHYPIQEDHGLGTLQCRVEGNYIVLSICVSVNMIILLFGSHPGLYLETYFSFPLAEILSVFPETGSLGGRTDITIIGDFFDNPAQVTIAGIPCDIRHVSPRRIECTTRAPSKGARLSAPQAGNRGLLFEVGDASEDLDLTEATPGYSWQIVPNASSPSGFWSKEGQPFRARLSGFFVAPETNNYTFWIQADNQASLYFSWSEDLRTKVKMASIRVGTADWFDSWEQNGSDKTQQQKTPKLELLGGARYYLEAEHRGRAPSSGVRIGVQIHNTWLNPDVVSTYLREKHQIRAWAQRLPEIQMLTLSGTGNFFLTWDNVSSQPIPANATAHQIQTAIEELLAVKCKLEPLSANILLWLGFEQGLEGSTSDGHLTSGTEPFCGRFSLHQPRHLVLTPPAVQKVYRLDQYTHLCLAYRGHENTTLKMTVSFTIGLQNPVKNITCDWSLLGTSPNWQFTCTDLWKMCVHHASHLQLPPANSPVLVHQIDLLPLSPEMGMFYVDEIIIADTNLTVSQADTGTARPGGNLLELLSVVGSPPVYSVTSWLAGCGLELPLITASAVPTEGAEEGSRLVQVTTQRLQRTSPPLGGHFRIQLSNTAIPGVPVHISASHLQKLLQTSADDFTSRYLNASDFTVTEDLKSCYEHVWTFSWSSRVGDLPNFIKVSNENLTGVNPAVTTRVVYDGGVFLGPIFGDMLVTANQHTQVVVRVNDIPAYCSGSCAFQYLEGSTPQVYSVWYALDDMDLLVYITGTSFSGDYKALQVTVNKTSCNVIFSNQTNVVCQTSLLPIGLHQISMLVRPSGLAINASGGGLFLNVEPRLDTVEPSRAADIGGLWATIRGSGLDNVNLVLFGSQSCVINVTTSNSRRIQCKVPSKGEDGPTVNVTVILGGHPVVLAMAFTYVSSLNPVIVSLSRNGSSIADPFHWNALPVNHTDLDAEVRIGDTRAWVLAQTAQGLEVVLPPLPAGLHGISVSINGVHIHAQGVDLHIQYITEVFSIQPCCGSLVGGTILSISGRGFSRDRALLWVLVGNRSCDIVNSTETSIWCETPPPAPLPLSAPVPVEVWAGSKPFPHRPSPRLVGKGFTFMYEVAATPVVTAMRGEVTNHSLRLYVEGQNLFDSVVLLGNLSCDLQTPSPGSNLSPAGCAFPLDTLEAGLYPLQVHQRQMGFADMSAVPQQCVVMPQITSIFPTRGSTCGGTVLTVRGLALRSSRGSVEVDLSGPFTCVILSLGDQTVLCRITPVGDPLPGTSFALNVTILVNGLPSTCQGNCTLFLCEETTPIVDEWTTNISGSLTTVLVRGQRLGITADEPVVFVDDRLACTVAFCNASHVACWISDLSPGPHYLSVFHARYGYACSGNLSRHFHVWPQVFHYFPKNFSLHGGSLLTLEGTALKGLNSTLVYIGQQACLTVSLGSELIQCAVPAGNGSAALVIEVDGLSYQMGVIGYSSAFTPELLSVSQTEDVLTFSVARISGAANVDIFIGMSPCVGVSGNHTLLHCLVPSLPTGEYQVRGYDRMRGWASSILVFTSRVTITAVTENFGRLGGRLVHVFGAGFSPGNISAAVCGAPCQVLANATVSAFSCLVLPLDVSLASLCDLRPEEEDCETASCSYVHCDLIITVGTESLPESWPYFYICEESSRCLLARDHWTESILPSFSGLFISPKVERDEVLIYNSSCTITMETEAKMECETPNQPITAKITEIRKSRGQNTQGNFIFQFCGRWSRAHSWFPQRPPQEGDNVTVEKGQLLLLDTNTSILNFLHVKGSWRTHSILVSDGGELRIGSEDKPFQGKARIKLYGSSYSARFFPYGVKFLAVRNGTLSLHGSLPEVVVTHLRAAANAHDTVLALEDAVDWHAGDEVLVISGMGAEDAKPKEEIVTVETVHSTDLQLRSPLRYSHNSTEKWVAGEHHVLKVMLVLLSRSITIQGNLTDERVQFLASCQGASASEGDLQNCLYSKSEKMLGSRDLGARVIVQSFPEEPSRVQLKGVQFRDLGQAFHEHVSSLMLVGAMRGSYVQGCTVRRSFSRGLSMSQTSGLKVDSNVFYDISGHALLLGTSPEIRYILWEVTSGGGKDWSEQGNIIRNNVIIRVSGAEGLSSPEVMTPSGIYIRHPTNVIEGNRVFAAGYGYFFHLVTNQTSQAPLLSFTRNSAHSCTRSGLFVYPKFQPPWDNSAGSTLFQNFTVWGSAGGAQIFRSSNLHLKNFQVYACRDFGIDVLESDANTSITDSLLLGHFAHKANLCMSAGIKSPRRWELRVSNTTFVNFDLTHCVAIRTCSGCSQGQGGFTVKTNQLKFMNSPNLVAFPSPHAAILEDLDGSLSGKNRSHILASMETLPATCVVKASFSQLVHGSVCEENVLFHRMSIGLASALKVSQDLTITDSRNKTTTVSYVHDTLSNPYGWMALLLDQETYSLRFESPWTSSALQYSATFDNFAPGNFLLLVHTDVWVYPDILIKCGSHVGRSLSSLPSPGQDQGCDWFFDSQLRQLTYLVSGEGQVKVVLQVRKGVDPTISASISVPESVLKWSLPEAWEGVAEGWGGHSGASPGPGEDVLILSNRTVLVDTDLPPLRGLYVMGTLEFPVDRSNVLSVACMLIAGGELRVGTSENPLEKEKKLLILLRASEGVFCDRFSGIHIDPGTIGVFGKVQLHSAYPKKSWTRLGADIASGNERIIVEDAVDWRPHDKIVLSSSSYEPHEAEVLTVKEVRGHHIRIHERLRHRHIGSAHVMEGGRHIRLAAEVGLLTRNIQIQGDTSCRGGLLVGSFRKSSVEEFSGILQLYNVEIQNFGSPLYSSIELTDVSTGSWVISSSLHQSCGGGIHAAASQGIILNDNVVFSTAGHGIDLEGQDYSLSKNLVVLMTQSAWSPVWVAGIKVNEAKNTRLHGNVVAGSERLGFHIQGHRCSAPESLWSDNVAHSSLHGLHLYKGSGLDSCTGISGFLAFKNFDYGAMLQVENSMEIENLTLVDNTVGLFTAVYVSSAPRYYIRSLQIVLRNSVIVATSSSFDCIQDRVKPHSAHLTSPDRAPSNPRGGRVGILWPVFTSEPNRWPQEPWHKVRNSHLISGIMKLQDVTFSSFVKSCYSDDLDVCILPNAENTGIVPPIMAERTSMLKIKDKNKFHFPPLQTRKDLETLVCSESDCESPGKYLFKDLDGRALGLPPPVSVFPKTEGEWTGSFFNTGTFREEQKCTYRPLINGYICKQTDPVILILDSADTTWAMQKLYPVVSVTSGFVDTFSSINASAPCSISRSVSAFYSIVPTRRITKVCFVDQTPDVLHFFLLGNKNTSKLLLAVFYHELQSPYVFSGDRFIPPTQVHSTSSLLNESIGSNYFSITDNLLYVVLQGEKPIEIRSSVSIHLALNVMFSVLEKGWEIVILERLTVFLQINQDQIRFIHQMPGNEATLKAMADSRAKRKRNCPTVTCTSHDRVGQRRPLMVEMSSYRDLPTMEMISKVMVIEIGDLPTVRNAGLIPSLSSNKLQNLAHQVIIAQQTGLLESVLNMTIGALLVTQSKGIIGYGNTSSFKTGNLIYVRPYGLSVFVQPSDGEVGKELTVQPQLVFLDKQNRRVESLGPPSEPWVISVSLEGTLDSVLRGCTHAETQDGYVSFSNLAVLISGSNWHFIFTVTSPPGVNFTARSRSFAVLPATPSERSTIIMAASLCSGVSWLALCCLVCCWFKKSKTRKIKNEEISETQTSDQRNHSHVSPKHQGSQVETEKEVTMMAEDLRMKVMLAKLNQLPHQSLNGVSRRKVSHRVVREEGGSREEAAVPAPSITSVTSPRNTCTPGSPAQQVYLQESGGWKGAQEQVLRYQLAGQDQLLLLCPDLRRERQRLQGQSQLGKGHISLGLSQKKPGSCGATEAFCLHSVHPEAVQEQL", "length": 4045 }, "evidence": [ { "id": "A0A0G2K2W1", "url": "https://omabrowser.org/oma/group/A0A0G2K2W1/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "E9PZ36-1", "protein_name": "Fibrocystin", "gene_name": "Pkhd1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MMLAWLVSLLSMEVLLLAKPYSSFQFEPAEGSLAGGTWITVVFDGLDRSILYPNNGSQLQIDLVSVAIPTLRIPCDVSPAFVDLPVVTCQTRSLPSEADAGPYSLEMRSGEQVLGTPCPGSLDSCTFKFSKDQTPVLYQVYPASGVPGEVVSVYGRVITTWLETFDPDVDYIESPLILEAREDKWLTPCSLINRQTGSCFPIQEEHGLGNVQCRVEGDYIGSQNVSFSVFNKGRSMVHKEAWLISAKQELFLYQTYPEILSVFPKVGSLGGRTDIIITGDFFDPSARVTIAGIPCDIRYVSPRKIECTTRAPGNEARLTAPQAGNRGLRFEVGDATKDVELTEATPGYRWQIVPNASSPSGFWSKEGRPFRARLSGFFVAPQTNNYTFWIQADSQASLCFSSSEEPRTKVEVASVGVGTADWFDSWEQIGNEGSWHQKTTKLELQGGAKYYLEAEQHGIAPSRGMRIGVQIHNTWLNPDVVNTYLLEKHQIRARAQRLPEIQVLHVSGKGNFFLTWGNVSSQPVPANATAQQIQTTIEELLVVKCNLAPFSAHVLLRLGFEQGLEGSRSDGVRTSSTEPFCGRFSLGQLGHLILIPEAADKGYQLDRYPYLCLAYRGHMNKTLDMTVSFLFGFQTIMKNITCDWSLTDPHPESWQFTCINLWDTCLCHSEDIQSSLANTPLLAHRIDIRPVVPEAGLLYVDEIILADTNVTVSQADSGRACPGGNVVESVSVVGVPPVYSISSWLAGCGSELPLITACSVSTEGTGDGSELIEVTAQRLQRTSPPLGGHFFLYLSDTVIPDVPVRMSARQLHKLLQDSADESTSGYLNAGDFTVTEDLNSCYEHVWTLSWTTQTGDLPNFIRVSDQNLTGVNPTVTARVVYDGGVFLGPIFGDMLATANQQTQVAVQVNDIPAYCSGSCSFQYQQESTPSVDHVWYSLGSDVNLLVHFTGTGFPRDTQFLQVTVNKTSCEVLFSNETNVACELALLPVGVHQIFMLVIPSGLAVHASGEDLLLHVEPRLDAVEPSTAAEIGGRWVTLRGSSLEGVSLVLFGTQSCVIDAIRSNSQQIQCKVPPRGKDGYTVNVTVISGDHSTVLARAFTYVSSLNPVIVSLSRNRSSIAGGEILFLGMSLLVNYTDLDVQIHVQDTSAQVLSQTAWGLEVVLPPLVPGIHVISAFINGVSIRSQGVDLYIQYLTEVFSVEPCSGSLLGGTLLSLLGTGLGRDPALIRVLVDNHPCDIVNLTEVNIWCETPPAVLPPRADVLTVLASVEIWAGNTSFFHGPSLVGKGFTFTYEAAATPVVTAMWGEFRNNSVRFYVEGSNISDSVILLGSLKCELEVQFFGDSMNLSGCFFPLHSLEAGVYTLQVRHKRMGFANMSVVPQKFELSPQIIAIFPTHGSKCGGTVLTVKGMAFSSRKRSVHVDISGPFACMILSLEDHTVLCQTRFVGDQFSEASLALNITVLVNGLTSKCKGNCTLFIEEAATPIVDALTISISGSLTMVLMRGRRLATTADEPIAFVDDQLPCHTTFFNTSHVACQIRDLAPGFHYLSAVHTSAGYACLNSVSRNFFIVPQVLDYFPKDFSIHGGSLLTIKGTALRGWKATVVYVGRQACLTVNFSSDFIQCIVPAGNGSAALEIDVNGVLYHIGLVDYSSIFTPELLSVSRSQDILTFTVARISGAANVDIFIGTSPCLGVAGNRTVLQCMVPLLPAGEYLVTGYDHSRGWASSTLILVLRATVTSVTKNYGCLGGRLLHVLGAGFSPGNISAAVCGAPCQVLANATVSAFSCLVLPLHVSLAFLCDLRHAEDSCKVRSSTYLRCDLTVSMGTERLPGSWPYVYLCEESSLCLFEPDHWTESVFPSFSGLFLSPKVERDEVLIYNSSCNITMETEAEMECEMPNQPITAKITEIQKSWGQNTQGNFSFQFCRRWSRPHSWFPQRVPHDGDSVTVETGHLLLLDANTSFLNSLHIKGGKLIFMDPGPIELRAHSILITDGGELHIGSEEKPFQGKARIKIYGSVHSTPFFPYGVKFLAVRNGTLSLHGSVPEVTVTYLQAAAHAGDKVLTLGEAVDWKPGDEAVITSGMTVAGAEATEVVVVETVHNADLHLRNPLRYSYDFRENWVAGENPILKPTVALLSRNIIIQGNFTLERVKLLNSCQEANTAKGNLKHCLYSKSEKMLGARDLGARVIIQSFPEEPSFVKLKGVQFRDLGQAFHKHLSSLALVGAMRGSYIQSCSVWNSFSRGLSMHRTWGLKVDSNVFYKIVGHALLLGSYLDGRFSTSETVTGRKNGWWEQGSTIRNNVIISVSAAEGLSGSEMLAPAGIYTFSPTNVMEGNRVCAAGYGYVFHLVTSQTLQAPLLSFNWNTAHSCTRYGLLVYPKFQPPWNNDTGFTLFQNFMVWGSAGGAQIFRSNNLHLKNFQVYACRDFGIDILESDANTLITDSFLLGHFTHKGSLCMSAGIKTPQRWELTISNTTFVNFDGNCVAIRTCSGCFQGQGGYTVKTRQLKFVNSSNLVAFPFPHAAVLEDLDGSLSGKNGSHVLASMETLSDTCLTNASFSQIVPGSVCGEAVLFHRMSIALANSLDVPKNLTITDISNKTITVNYVEDTLSNYYGWMALLLDQETYSLQFESPWMNRSLQYSATFDSFAPGNYLLIMHRDLPPYPDILLRCGSQVGHSLPFHPLPSQDRACDWFFNRQLRQLTYLVSGEGQVKVFLQLKPGVPPSVSASTSVPESASRWSLPETWQDVEKGWGGYNHTIPGPGDDVLILPNKTVLVDTDLPVLRCLYVMGTLEFPVDRSNVLSVACLLIAGGELKVGTLENPLEKDQRLLIFLRASEEVVCDYFEGIHVDPGTIGVYGKLRLHSAYPKKSWVHLGADIAPGNERIIVHNAVDWQPHDTIVLSSSSYEAHEAEVLTVKEVKGHHIRIYERLKHRHIGSTHTMEDGQQVHLAAEVGLLTRNIRIQPDSSCRGRLLVGSFRKSSGEDFSGVLQLLNVEIQNMGLPLYSSIEFTGVSAGSWVISSTVHQSCSVGIHASSSHGVILTDNVVFGTNGHGIDVEGQNYSLTNNLVILTMQSANSSPWVAGIKVNYAEDIILHGNVVAGSERLGFHVGGHGCSSEVLWSDNVVHSSLHGLHLYKKHESNNCTGVSGFMAFKNFDYGAMVQTENSVDIQNITLVDNTVGLLAITYVSSALLSSVSTVQITLRNSVIVATSSSFDCIHDRKAPQSANWTSTDRAPSNPRGGRIGILWPVSASEPNAWPQEPWHKVRSRHSVPGIMKLQDVTFSSFVKSCYSNDLDVCILPNEYSTGVMYPITAERTRMLGIKDKNKFYFPVLQSSKDLVGTICPTLVCEYPRKYLFTDLDGRTLGLPPPVSVFPRTEEEWTGSFLNTGIFREEQKCTFRAMNQGFFCKQTEHAVLILDNVDATWTIPKSHPLVSVTNGFVDTFSIVKDSDLCPPTSSLSTFYSILPTRQMTKVCFPEQTPPFLRFLLLGNQRASKLILAVFYNEIQSPHVFLDKSFIPPTPLESAFSLLAEPSGANYFDIMNNLLYVVLQGEEPVEIHSSVSIHLALTVTFSVLEKGWERAMLESLSDFFQIDPNQIRLTLEMPGNKETLEAIANSERKRKRNCPSVTCGGPSIRYGQRRPLMAEMTSLKITPATTLETFSKVIVIEVGDLPNIRNSEPIQSLPSNRLQRLVNQVITAQQTGALENVLGMTVGALLVTQSKGVTGYRNASSLITGNLIYTRPSELSILVQPSDGEVGIELPVQPRLVFLDEKNERVESLGLPSEPWIISVSLEGASESVLKGCTLAETRDGYVTFSRLAVLISGSNWHLFFTVISPPGTNFTARSRTFVVLPVASKERSTIILALSLCSVASWVALSCLVCCWFKKSKTRKIKPEDISESQAKEQKKNTHNSSKPRGLQAKTAKENTLMGEDMRMKVMQGMQSQFPQHSMDGVSKRKVSRLAVTEERTTTPAPKIPRITCVPGSLAQQLTLQEPGNWQEAQQQLLRYQLAGRNQLLLLRPDLRQERKQGQEPSQLDKGSDCTGLSQEKATCIPTETFSLHTAPPETIQ", "length": 4059 }, "evidence": [ { "id": "A0A0G2K2W1", "url": "https://omabrowser.org/oma/group/A0A0G2K2W1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P08F94-1", "protein_name": "Fibrocystin", "gene_name": "PKHD1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTAWLISLMSIEVLLLAVRHLSLHIEPEEGSLAGGTWITVIFDGLELGVLYPNNGSQLEIHLVNVNMVVPALRSVPCDVFPVFLDLPVVTCRTRSVLSEAHEGLYFLEAYFGGQLVSSPNPGPRDSCTFKFSKAQTPIVHQVYPPSGVPGKLIHVYGWIITGRLETFDFDAEYIDSPVILEAQGDKWVTPCSLINRQMGSCYPIQEDHGLGTLQCHVEGDYIGSQNVSFSVFNKGKSMVHKKAWLISAKQDLFLYQTHSEILSVFPETGSLGGRTNITITGDFFDNSAQVTIAGIPCDIRHVSPRKIECTTRAPGKDVRLTTPQPGNRGLLFEVGDAVEGLELTEATPGYRWQIVPNASSPFGFWSQEGQPFRARLSGFFVAPETNNYTFWIQADSQASLHFSWSEEPRTKVKVASISVGTADWFDSWEQNRDEGTWQQKTPKLELLGGAMYYLEAEHHGIAPSRGMRIGVQIHNTWLNPDVVTTYLREKHQIRVRAQRLPEVQVLNVSGRGNFFLTWDNVSSQPIPANATAHLIQTTIEELLAVKCKLEPLWSNILLRLGFERGPEVSNSDGDLTSGTEPFCGRFSLRQPRHLVLTPPAAQKGYRLDQYTHLCLAYKGHMNKILKMIVSFTIGFQNMVKNTTCDWSLTRTSPESWQFDCTDLWETCVRCFGDLQPPPANSPVLVHQINLLPLAQETGLFYVDEIIIADTNVTVSQADSGTARPGGNLVESVSVVGSPPVYSVTSWLAGCGTELPLITARSVPTEGTEEGSGLVLVTTQRRQRTSPPLGGHFRIQLPNTVISDVPVQISAHHLHQLLQNNADDFTSRYLNASDFTVKEDLYTCYEHVWTLSWSTQIGDLPNFIRVSDENLTGVNPAAATRVVYDGGVFLGPIFGDMLATANQHTQVVVRVNDVPAHCPGSCSFQYLQGSTPCVHSVWYSIDGDINLMIYITGTGFSGDSQFLQVTVNKTSCKVIFSNQTNVVCQTDLLPVGMHRILMLVRPSGLAISATGEDLFLNVKPRLDMVEPSRAADIGGLWATIRGSSLEGVSLILFGSYSCAINVATSNSSRIQCKVPPRGKDGRIVNVTVIRGDYSAVLPRAFTYVSSLNPVIVTLSRNISNIAGGETLVIGVARLMNYTDLDVEVHVQDALAPVHTQSAWGLEVALPPLPAGLHRISVSINGVSIHSQGVDLHIQYLTEVFSIEPCCGSLLGGTILSISGIGFSRDPALVWVLVGNRSCDIVNLTEASIWCETLPAPQIPDAGAPTVPAAVEVWAGNRFFARGPSPSLVGKGFTFMYEAAATPVVTAMQGEITNSSLSLHVGGSNLSNSVILLGNLNCDVETQSFQGNVSLSGCSIPLHSLEAGIYPLQVRQKQMGFANMSVVLQQFAVMPRIMAIFPSQGSACGGTILTVRGLLLNSRRRSVRVDLSGPFTCVILSLGDHTILCQVSLEGDPLPGASFSLNVTVLVNGLTSECQGNCTLFIREEASPVMDALSTNTSGSLTTVLIRGQRLATTADEPMVFVDDQLPCNVTFFNASHVVCQTRDLAPGPHYLSVFYTRNGYACSGNVSRHFYIMPQVFHYFPKNFSLHGGSLLTIEGTGLRGQNTTSVYIDQQTCLTVNIGAELIRCIVPTGNGSVALEIEVDGLWYHIGVIGYNKAFTPELISISQSDDILTFAVAQISGAANIDIFIGMSPCVGVSGNHTVLQCVVPSLPAGEYHVRGYDCIRGWASSALVFTSRVIITAVTENFGCLGGRLVHVFGAGFSPGNVSAAVCGAPCRVLANATVSAFSCLVLPLDVSLAFLCGLKREEDSCEAARHTYVQCDLTVAMATEQLLESWPYLYICEESSQCLFVPDHWAESMFPSFSGLFISPKLERDEVLIYNSSCNITMETEAEMECETPNQPITVKITEIRKRWGQNTQGNFSLQFCRRWSRTHSWFPERLPQDGDNVTVENGQLLLLDTNTSILNLLHIKGGKLIFMAPGPIELRAHAILVSDGGELRIGSEDKPFQGRAQITLYGSSYSTPFFPYGVKFLAVRNGTLSLHGSLPEVIVTCLRATAHALDTVLALEDAVDWNPGDEVVIISGTGVKGAKPMEEIVTVETVQDTDLYLKSPLRYSHNFTENWVAGEHHILKATVALLSRSITIQGNLTNEREKLLVSCQEANAPEGNLQHCLYSMSEKMLGSRDMGARVIVQSFPEEPSQVQLKGVQFQVLGQAFHKHLSSLTLVGAMRESFIQGCTVRNSFSRGLSMCGTLGLKVDSNVFYNILGHALLVGTCTEMRYISWEAIHGRKDDWSGHGNIIRNNVIIQVSGAEGLSNPEMLTPSGIYICSPTNVIEGNRVCGAGYGYFFHLMTNQTSQAPLLSFTQNIAHSCTRYGLFVYPKFQPPWDNVTGTTLFQSFTVWESAGGAQIFRSSNLRLKNFKVYSCRDFGIDVLESDANTSVTDSLLLGHFAHKGSLCMSSGIKTPKRWELMVSNTTFVNFDLINCVAIRTCSDCSQGQGGFTVKTSQLKFTNSSNLVAFPFPHAAILEDLDGSLSGKNRSHILASMETLSASCLVNSSFGRVVHGSACGGGVLFHRMSIGLANTPEVSYDLTMTDSRNKTTTVNYVRDTLSNPRGWMALLLDQETYSLQSENLWINRSLQYSATFDNFAPGNYLLLVHTDLPPYPDILLRCGSRVGLSFPFLPSPGQNQGCDWFFNSQLRQLTYLVSGEGQVQVILRVKEGMPPTISASTSAPESALKWSLPETWQGVEEGWGGYNNTIPGPGDDVLILPNRTVLVDTDLPFFKGLYVMGTLDFPVDRSNVLSVACMVIAGGELKVGTLENPLEKEQKLLILLRASEGVFCDRMNGIHIDPGTIGVYGKVHLYSAYPKNSWTHLGADIASGNERIIVEDAVDWRPHDKIVLSSSSYEPHEAEVLTVKEVKGHHVRIYERLKHRHIGSVHVTEDGRHIRLAAEVGLLTRNIQIQPDVSCRGRLFVGSFRKSSREEFSGVLQLLNVEIQNFGSPLYSSVEFSNVSAGSWIISSTLHQSCGGGIHAAASHGVLLNDNIVFGTAGHGIDLEGQAYTVTNNLVVLMTQPAWSTIWVAGIKVNQVKDINLHGNVVAGSERLGFHIRGHKCSSCELLWSDNVAHSSLHGLHLYKESGLDNCTRISGFLAFKNFDYGAMLHVENSVEIENITLVDNTIGLLAVVYVFSAPQNSVKKVQIVLRNSVIVATSSSFDCIQDKVKPHSANLTSTDRAPSNPRGGRIGILWPVFTSEPNQWPQEPWHKVRNDHSISGIMKLQDVTFSSFVKSCYSDDLDVCILPNAENSGIMHPITAERTRMLKIKDKNKFYFPSLQPRKDLGKVVCPELDCASPRKYLFKDLDGRALGLPPPVSVFPKTEAEWTASFFNAGTFREEQKCTYQFLMQGFICKQTDQVVLILDSADAIWAIQKLYPVVSVTSGFVDVFSSVNANIPCSTSGSVSTFYSILPIRQITKVCFMDQTPQVLRFFLLGNKSTSKLLLAVFYHELQSPHVFLGESFIPPTLVQSASLLLNESIGANYFNIMDNLLYVVLQGEEPIEIRSGVSIHLALTVMVSVLEKGWEIVILERLTNFLQIGQNQIRFIHEMPGHEETLKAIADSRAKRKRNCPTVTCTSHYRRVGQRRPLMMEMNSHRASPPMTVETISKVIVIEIGDSPTVRSTGMISSLSSNKLQNLAHRVITAQQTGVLENVLNMTIGALLVTQSKGVIGYGNTSSFKTGNLIYIRPYALSILVQPSDGEVGNELPVQPQLVFLDEQNRRVESLGPPSEPWTISASLEGASDSVLKGCTQAETQDGYVSFYNLAVLISGSNWHFIFTVTSPPGVNFTARSKPFAVLPVTRKEKSTIILAASLSSVASWLALSCLVCCWLKRSKSRKTKPEEIPESQTNNQNIHIHISSKRRESQGPKKEDTVVGEDMRMKVMLGKVNQCPHQLMNGVSRRKVSRHIVREEEAAVPAPGTTGITSHGHICAPGAPAQQVYLQETGNWKEGQEQLLRYQLAGQNQLLLLCPDFRQERQQLPGQSRLSKQSGSLGLSQEKKASCGATEAFCLHSVHPETIQEQL", 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"id": "A0A0G2K2W1", "url": "https://www.uniprot.org/uniprot/A0A0G2K2W1" } ], "pmid": "" }, { "name": "negative regulation of apoptotic process", "id": "GO:0043066", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043066", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2W1", "url": "https://www.uniprot.org/uniprot/A0A0G2K2W1" } ], "pmid": "" }, { "name": "kidney development", "id": "GO:0001822", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001822", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2W1", "url": "https://www.uniprot.org/uniprot/A0A0G2K2W1" } ], "pmid": "" }, { "name": "intracellular calcium ion homeostasis", "id": "GO:0006874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006874", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2W1", "url": "https://www.uniprot.org/uniprot/A0A0G2K2W1" } ], "pmid": "" }, { "name": "cilium assembly", "id": "GO:0060271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271", "evidence": [ { "database": "UniProtKB", 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