{ "uniprot_canonical_ac": "A0A0G2K2P5-1", "uniprot_ac": "A0A0G2K2P5", "uniprot_id": "ZO1_RAT", "mass": { "chemical_mass": 197148.0, "monoisotopic_mass": 197148.0 }, "refseq": {}, "gene_names": [ { "name": "Tjp1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A0G2K2P5", "id": "A0A0G2K2P5" } ], "protein_names": [ { "name": "Tight junction protein ZO-1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2P5/entry#names_and_taxonomy", "id": "A0A0G2K2P5" }, { "name": "Tight junction protein 1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2P5/entry#names_and_taxonomy", "id": "A0A0G2K2P5" }, { "name": "Zona occludens protein 1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2P5/entry#names_and_taxonomy", "id": "A0A0G2K2P5" }, { "name": "Zonula occludens protein 1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2P5/entry#names_and_taxonomy", "id": "A0A0G2K2P5" } ], "function": [ { "annotation": "TjpP1, Tjp2, and Tjp3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:9707407). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting Cdc42bpb to the leading edge of migrating cells (By similarity). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (By similarity). With Tjp2 and Tjp3, participates in the junctional retention and stability of the transcription factor Dbpa, but is not involved in its shuttling to the nucleus (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2P5", "url": "https://www.uniprot.org/uniprot/A0A0G2K2P5#function" }, { "database": "UniProtKB", "id": "O97758", "url": "https://www.uniprot.org/uniprot/O97758#function" }, { "database": "PubMed", "id": "9707407", "url": "https://glygen.org/publication/PubMed/9707407" }, { "database": "UniProtKB", "id": "Q07157", "url": "https://www.uniprot.org/uniprot/Q07157#function" } ] } ], "disease": [ { "disease_id": "DOID:13141", "recommended_name": { "id": "DOID:13141", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:13141", "name": "uveitis", "description": "An uveal disease is characterized by inflammation of any of the layers of the uvea of the eye, which includes the iris, ciliary body, and choroid." }, "synonyms": [], "evidence": [ { "id": "13141", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:13141" } ] }, { "disease_id": "DOID:13580", "recommended_name": { "id": "DOID:13580", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:13580", "name": "cholestasis", "description": "A bile duct disease that is characterized by where bile cannot flow from the liver to the duodenum." }, "synonyms": [ { "id": "DOID:13580", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:13580", "name": "Obstruction of bile duct", "description": "" }, { "id": "DOID:13580", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:13580", "name": "bile occlusion", "description": "" } ], "evidence": [ { "id": "13580", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:13580" } ] }, { "disease_id": "DOID:13976", "recommended_name": { "id": "DOID:13976", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:13976", "name": "peptic esophagitis", "description": "" }, "synonyms": [ { "id": "DOID:13976", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:13976", "name": "Peptic reflux disease", "description": "" }, { "id": "DOID:13976", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:13976", "name": "Reflux oesophagitis", "description": "" }, { "id": "DOID:13976", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:13976", "name": "reflux esophagitis", "description": "" } ], "evidence": [ { "id": "13976", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:13976" } ] }, { "disease_id": "DOID:2316", "recommended_name": { "id": "DOID:2316", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2316", "name": "brain ischemia", "description": "An ischemia that is characterized by insufficient blood flow to the brain to meet metabolic demand." }, "synonyms": [ { "id": "DOID:2316", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2316", "name": "Ischaemic encephalopathy", "description": "" }, { "id": "DOID:2316", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2316", "name": "Ischemic encephalopathy", "description": "" }, { "id": "DOID:2316", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2316", "name": "cerebral ischemia", "description": "" } ], "evidence": [ { "id": "2316", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:2316" } ] }, { "disease_id": "DOID:4606", "recommended_name": { "id": "DOID:4606", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4606", "name": "bile duct cancer", "description": "A biliary tract cancer that is located_in the bile duct." }, "synonyms": [ { "id": "DOID:4606", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4606", "name": "Ca extrahepatic bile ducts", "description": "" }, { "id": "DOID:4606", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4606", "name": "bile duct tumor", "description": "" }, { "id": "DOID:4606", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4606", "name": "malignant neoplasm of the extrahepatic bile duct", "description": "" } ], "evidence": [ { "id": "4606", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:4606" } ] }, { "disease_id": "DOID:4948", "recommended_name": { "id": "DOID:4948", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4948", "name": "gallbladder carcinoma", "description": "A gallbladder cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells." }, "synonyms": [ { "id": "DOID:4948", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4948", "name": "cancer of the gallbladder", "description": "" }, { "id": "DOID:4948", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4948", "name": "carcinoma gallbladder", "description": "" }, { "id": "DOID:4948", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4948", "name": "carcinoma of gallbladder", "description": "" } ], "evidence": [ { "id": "4948", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:4948" } ] }, { "disease_id": "DOID:8677", "recommended_name": { "id": "DOID:8677", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8677", "name": "perinatal necrotizing enterocolitis", "description": "" }, "synonyms": [ { "id": "DOID:8677", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8677", "name": "ENTEROCOLITIS NECROTIZING", "description": "" }, { "id": "DOID:8677", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8677", "name": "Necrotizing enterocolitis in fetus OR newborn", "description": "" }, { "id": "DOID:8677", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8677", "name": "Perinatal necrotising enterocolitis", "description": "" }, { "id": "DOID:8677", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8677", "name": "Pseudomembranous enterocolitis in newborn", "description": "" }, { "id": "DOID:8677", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8677", "name": "necrotizing enterocolitis", "description": "" } ], "evidence": [ { "id": "8677", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:8677" } ] }, { "disease_id": "DOID:936", "recommended_name": { "id": "DOID:936", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:936", "name": "brain disease", "description": "A central nervous system disease that is located_in the brain." }, "synonyms": [ { "id": "DOID:936", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:936", "name": "encephalopathy", "description": "" } ], "evidence": [ { "id": "936", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:936" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2P5", "url": "https://www.uniprot.org/uniprot/A0A0G2K2P5" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "gene": [ { "name": "Tjp1", "url": "https://www.uniprot.org/uniprot/A0A0G2K2P5", "locus": { "chromosome": "1", "start_pos": 118849838, "end_pos": 119094432, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000011077", "url": "https://www.ensembl.org/id/ENSRNOG00000011077" } ] } } ], "crossref": [ { "id": "A0A0G2K2P5", "url": "https://alphafold.ebi.ac.uk/entry/A0A0G2K2P5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSRNOG00000011077", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000011077", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00992", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00992", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12026", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12026", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "A0A0G2K2P5", "url": "https://www.ebi.ac.uk/intact/interactors/id:A0A0G2K2P5*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "F1M4A0", "url": "https://www.ebi.ac.uk/intact/interactors/id:F1M4A0*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000906", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000906", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001478", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001478", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005418", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005418", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008144", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008144", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008145", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008145", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035597", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035597", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036028", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036028", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036034", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036034", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "QPVHRID", "url": "https://omabrowser.org/oma/group/QPVHRID/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1M4A0", "url": "https://www.orthodb.org/?gene=F1M4A0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13865", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13865", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13865:SF25", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13865:SF25", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00595", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00595", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00625", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00625", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00791", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00791", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF07653", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07653", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_A0A0G2K2P5", "url": "http://purl.obolibrary.org/obo/PR_A0A0G2K2P5", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-RNO-191650", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-191650", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-2028269", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2028269", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-351906", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-351906", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "1306305", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1306305", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "A0A0G2K2P5", "url": "https://www.uniprot.org/uniprot/A0A0G2K2P5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2K2P5-1", "url": "https://www.uniprot.org/uniprot/A0A0G2K2P5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6AFQ2", "url": "https://www.uniprot.org/uniprot/A0A8I6AFQ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6AFQ2-1", "url": "https://www.uniprot.org/uniprot/A0A8I6AFQ2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8L2R644", "url": "https://www.uniprot.org/uniprot/A0A8L2R644", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8L2R644-1", "url": "https://www.uniprot.org/uniprot/A0A8L2R644-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1M4A0", "url": "https://www.uniprot.org/uniprot/F1M4A0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1M4A0-1", "url": "https://www.uniprot.org/uniprot/F1M4A0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSARAAAAKSTAMEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSHPDPDPVSDNEDDSYDEDVHDPRSGRGALANRRGEKSWARDRSASRDRSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSANASERDDISEIQSLASDHSVRSHDRPPRRSQSRSPDQRSEPSDHSTQSPQQPSNGSLRSREEERMSKPGAVSTPVKHVDDHTPKAVEEVTVEKHEKQTPTLPEPKPVYAQVGQPDVDLPVSPSDGVLPNSTHEDGILRPSMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLEEGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIRTHFEYEKESPYGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIVPNKNRAEQLASVQYTLPKTAGGDRADFWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREKLAREEPDIYQIAKSEPRDAGTDHRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSYLSAPGSEYSMYSTDSRHTSDYEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSEPVREDSSGMHHENQTYPPYSPQAQPQAIHRIDSPGLKTASQQKAEASSPVPYLSPETNPASSASAVKHNVNLTNVNLEEPTPAPPTSHVSQADCLGAPSPEAPHTMLRDEGVSLPSHVDPAKVYRKEPYPEEMMRQNHILKQPALGHPGQRLDKEPNPAYDPQLPYVEKQASRDLEQPPYRYESSSYTDQFSRNYDHRLRFEDRVPTYEDQWSYYDDKQPYPTRPFDTQHPRDLDSRQHPEEASERGYFQRFEEPAPLPYDSRPRYEQLPRTSTLRHEEQPTSGYEVHNRYRPEAQPYAPAGPKSSEPKQYFDQYPRSYEQVPPPGFTSKTGHYEPLHGAAVVPPLIPSSQHKPEVLPSATKPQPPPPALTEEEEDPAMKPQSVLTRVKMFENKRSASLENKKDVNDTASFKPPEVASKPPSASLVGPKPVSQTQFSEHDKTLYRLPEPQKPQAKPPEDIVRSNHYDPEEDEEYYRKQLSYFDRRSFESKPPAHIPAGHHSEPAKPVHSQSQPNFSSYSSKGKPETDAMDRSFSEKRYDPTQAMPPPPPLPSQYSQPVPPLSNSSLHIHSKAAQSEGNSVSLDFQNSYISKPDPPPSQSKPATFRPPTREDPPQTFYPQKSFPDKASVNGAEQTQKTITPAYNRFTPKPYTSSARPFERKFESPKFNHNLLPSETVHKPELSSKPPPSPKTLMKAHSSTQPPEFDSGVETFSVHTDKPKYQINNISTMPKAVPVSPSAVEEDEDEDGHTVVATARGIFNSNGGVLSSIETGVSIIIPQGAIPEGIEQEIYFKVCRDNSILPPLDKEKGETLLSPLVMCGPHGLKFLKPVELRLPHCASMTPDGWSFALKSSDSSSGDPKTWQNKCLPGDPNYLVGANCVSVLIDHF", "length": 1765, "header": "sp|A0A0G2K2P5-1|ZO1_RAT Isoform 1 of Tight junction protein ZO-1 OS=Rattus norvegicus OX=10116 GN=Tjp1 PE=1 SV=1 CANONICAL=A0A0G2K2P5-1" }, "isoforms": [ { "isoform_ac": "A0A0G2K2P5-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2P5/entry#A0A0G2K2P5-1", "sequence": { "sequence": "MSARAAAAKSTAMEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSHPDPDPVSDNEDDSYDEDVHDPRSGRGALANRRGEKSWARDRSASRDRSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSANASERDDISEIQSLASDHSVRSHDRPPRRSQSRSPDQRSEPSDHSTQSPQQPSNGSLRSREEERMSKPGAVSTPVKHVDDHTPKAVEEVTVEKHEKQTPTLPEPKPVYAQVGQPDVDLPVSPSDGVLPNSTHEDGILRPSMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLEEGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIRTHFEYEKESPYGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIVPNKNRAEQLASVQYTLPKTAGGDRADFWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREKLAREEPDIYQIAKSEPRDAGTDHRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSYLSAPGSEYSMYSTDSRHTSDYEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSEPVREDSSGMHHENQTYPPYSPQAQPQAIHRIDSPGLKTASQQKAEASSPVPYLSPETNPASSASAVKHNVNLTNVNLEEPTPAPPTSHVSQADCLGAPSPEAPHTMLRDEGVSLPSHVDPAKVYRKEPYPEEMMRQNHILKQPALGHPGQRLDKEPNPAYDPQLPYVEKQASRDLEQPPYRYESSSYTDQFSRNYDHRLRFEDRVPTYEDQWSYYDDKQPYPTRPFDTQHPRDLDSRQHPEEASERGYFQRFEEPAPLPYDSRPRYEQLPRTSTLRHEEQPTSGYEVHNRYRPEAQPYAPAGPKSSEPKQYFDQYPRSYEQVPPPGFTSKTGHYEPLHGAAVVPPLIPSSQHKPEVLPSATKPQPPPPALTEEEEDPAMKPQSVLTRVKMFENKRSASLENKKDVNDTASFKPPEVASKPPSASLVGPKPVSQTQFSEHDKTLYRLPEPQKPQAKPPEDIVRSNHYDPEEDEEYYRKQLSYFDRRSFESKPPAHIPAGHHSEPAKPVHSQSQPNFSSYSSKGKPETDAMDRSFSEKRYDPTQAMPPPPPLPSQYSQPVPPLSNSSLHIHSKAAQSEGNSVSLDFQNSYISKPDPPPSQSKPATFRPPTREDPPQTFYPQKSFPDKASVNGAEQTQKTITPAYNRFTPKPYTSSARPFERKFESPKFNHNLLPSETVHKPELSSKPPPSPKTLMKAHSSTQPPEFDSGVETFSVHTDKPKYQINNISTMPKAVPVSPSAVEEDEDEDGHTVVATARGIFNSNGGVLSSIETGVSIIIPQGAIPEGIEQEIYFKVCRDNSILPPLDKEKGETLLSPLVMCGPHGLKFLKPVELRLPHCASMTPDGWSFALKSSDSSSGDPKTWQNKCLPGDPNYLVGANCVSVLIDHF", "length": 1765, "header": "sp|A0A0G2K2P5-1|ZO1_RAT Isoform 1 of Tight junction protein ZO-1 OS=Rattus norvegicus OX=10116 GN=Tjp1 PE=1 SV=1 CANONICAL=A0A0G2K2P5-1" }, "locus": { "chromosome": "1", "start_pos": 118931479, "end_pos": 118851242, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000112594.1", "url": "https://www.ensembl.org/id/ENSRNOT00000112594.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000078542.1", "url": "https://www.ensembl.org/id/ENSRNOP00000078542.1" } ] } }, { "isoform_ac": "A0A8I6AFQ2-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2P5/entry#A0A8I6AFQ2-1", "sequence": { "sequence": "MKYQKYLTVLQMAIGVTPSNRGSLLPLKRKLWVTPSSENPHGATSNVSQGKPSLRRIKGRLHRSKSLDSIDFCELTSTAMEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSHPDPDPVSDNEDDSYDEDVHDPRSGRGALANRRGEKSWARDRSASRDRSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSANASERDDISEIQSLASDHSVRSHDRPPRRSQSRSPDQRSEPSDHSTQSPQQPSNGSLRSREEERMSKPGAVSTPVKHVDDHTPKAVEEVTVEKHEKQTPTLPEPKPVYAQVGQPDVDLPVSPSDGVLPNSTHEDGILRPSMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLEEGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIRTHFEYEKESPYGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIVPNKNRAEQLASVQYTLPKTAGGDRADFWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREKLAREEPDIYQIAKSEPRDAGTDHRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSYLSAPGSEYSMYSTDSRHTSDYEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSEPVREDSSGMHHENQTYPPYSPQAQPQAIHRIDSPGLKTASQQVYRKEPYPEEMMRQNHILKQPALGHPGQRLDKEPNPAYDPQLPYVEKQASRDLEQPPYRYESSSYTDQFSRNYDHRLRFEDRVPTYEDQWSYYDDKQPYPTRPFDTQHPRDLDSRQHPEEASERGYFQRFEEPAPLPYDSRPRYEQLPRTSTLRHEEQPTSGYEVHNRYRPEAQPYAPAGPKSSEPKQYFDQYPRSYEQVPPPGFTSKTGHYEPLHGAAVVPPLIPSSQHKPEVLPSATKPQPPPPALTEEEEDPAMKPQSVLTRVKMFENKRSASLENKKDVNDTASFKPPEVASKPPSASLVGPKPVSQTQFSEHDKTLYRLPEPQKPQAKPPEDIVRSNHYDPEEDEEYYRKQLSYFDRRSFESKPPAHIPAGHHSEPAKPVHSQSQPNFSSYSSKGKPETDAMDRSFSEKRYDPTQAMPPPPPLPSQYSQPVPPLSNSSLHIHSKAAQSEGNSVSLDFQNSYISKPDPPPSQSKPATFRPPTREDPPQTFYPQKSFPDKASVNGAEQTQKTITPAYNRFTPKPYTSSARPFERKFESPKFNHNLLPSETVHKPELSSKPPPSPKTLMKAHSSTQPPEFDSGVETFSVHTDKPKYQINNISTMPKAVPVSPSAVEEDEDEDGHTVVATARGIFNSNGGVLSSIETGVSIIIPQGAIPEGIEQEIYFKVCRDNSILPPLDKEKGETLLSPLVMCGPHGLKFLKPVELRLPHCASMTPDGWSFALKSSDSSSGDPKTWQNKCLPGDPNYLVGANCVSVLIDHF", "length": 1752, "header": "tr|A0A8I6AFQ2-1|ZO1_RAT Computationally mapped isoform of Tight junction protein ZO-1 OS=Rattus norvegicus OX=10116 GN=Tjp1 PE=1 SV=1 CANONICAL=A0A0G2K2P5-1" }, "locus": { "chromosome": "1", "start_pos": 119094399, "end_pos": 118851242, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000096674.1", "url": "https://www.ensembl.org/id/ENSRNOT00000096674.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000093370.1", "url": "https://www.ensembl.org/id/ENSRNOP00000093370.1" } ] } }, { "isoform_ac": "A0A8L2R644-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2P5/entry#A0A8L2R644-1", "sequence": { "sequence": "MKDSYSASTAMEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSHPDPDPVSDNEDDSYDEDVHDPRSGRGALANRRGEKSWARDRSASRDRSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSANASERDDISEIQSLASDHSVRSHDRPPRRSQSRSPDQRSEPSDHSTQSPQQPSNGSLRSREEERMSKPGAVSTPVKHVDDHTPKAVEEVTVEKHEKQTPTLPEPKPVYAQVGQPDVDLPVSPSDGVLPNSTHEDGILRPSMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLEEGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIRTHFEYEKESPYGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIVPNKNRAEQLASVQYTLPKTAGGDRADFWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREKLAREEPDIYQIAKSEPRDAGTDHRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSYLSAPGSEYSMYSTDSRHTSDYEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSEPVREDSSGMHHENQTYPPYSPQAQPQAIHRIDSPGLKTASQQKAEASSPVPYLSPETNPASSASAVKHNVNLTNVNLEEPTPAPPTSHVSQADCLGAPSPEAPHTMLRDEGVSLPSHVDPAKVYRKEPYPEEMMRQNHILKQPALGHPGQRLDKEPNPAYDPQLPYVEKQASRDLEQPPYRYESSSYTDQFSRNYDHRLRFEDRVPTYEDQWSYYDDKQPYPTRPFDTQHPRDLDSRQHPEEASERGYFQRFEEPAPLPYDSRPRYEQLPRTSTLRHEEQPTSGYEVHNRYRPEAQPYAPAGPKSSEPKQYFDQYPRSYEQVPPPGFTSKTGHYEPLHGAAVVPPLIPSSQHKPEVLPSATKPQPPPPALTEEEEDPAMKPQSVLTRVKMFENKRSASLENKKDVNDTASFKPPEVASKPPSASLVGPKPVSQTQFSEHDKTLYRLPEPQKPQAKPPEDIVRSNHYDPEEDEEYYRKQLSYFDRRSFESKPPAHIPAGHHSEPAKPVHSQSQPNFSSYSSKGKPETDAMDRSFSEKRYDPTQAMPPPPPLPSQYSQPVPPLSNSSLHIHSKAAQSEGNSVSLDFQNSYISKPDPPPSQSKPATFRPPTREDPPQTFYPQKSFPDKASVNGAEQTQKTITPAYNRFTPKPYTSSARPFERKFESPKFNHNLLPSETVHKPELSSKPPPSPKTLMKAHSSTQPPEFDSGVETFSVHTDKPKYQINNISTMPKAVPVSPSAVEEDEDEDGHTVVATARGIFNSNGGVLSSIETGVSIIIPQGAIPEGIEQEIYFKVCRDNSILPPLDKEKGETLLSPLVMCGPHGLKFLKPVELRLPHCASMTPDGWSFALKSSDSSSGDPKTWQNKCLPGDPNYLVGANCVSVLIDHF", "length": 1763, "header": "tr|A0A8L2R644-1|ZO1_RAT Computationally mapped isoform of Tight junction protein ZO-1 OS=Rattus norvegicus OX=10116 GN=Tjp1 PE=1 SV=1 CANONICAL=A0A0G2K2P5-1" }, "locus": { "chromosome": "1", "start_pos": 118915820, "end_pos": 118851242, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000087332.2", "url": "https://www.ensembl.org/id/ENSRNOT00000087332.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000072324.2", "url": "https://www.ensembl.org/id/ENSRNOP00000072324.2" } ] } }, { "isoform_ac": "F1M4A0-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2P5/entry#F1M4A0-1", "sequence": { "sequence": "MIVTCNHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSHPDPDPVSDNEDDSYDEDVHDPRSGRGALANRRGEKSWARDRSASRDRSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSANASERDDISEIQSLASDHSVRSHDRPPRRSQSRSPDQRSEPSDHSTQSPQQPSNGSLRSREEERMSKPGAVSTPVKHVDDHTPKAVEEVTVEKHEKQTPTLPEPKPVYAQVGQPDVDLPVSPSDGVLPNSTHEDGILRPSMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLEEGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIRTHFEYEKESPYGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIVPNKNRAEQLASVQYTLPKTAGGDRADFWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREKLAREEPDIYQIAKSEPRDAGTDHRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSYLSAPGSEYSMYSTDSRHTSDYEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSEPVREDSSGMHHENQTYPPYSPQAQPQAIHRIDSPGLKTASQQKAEASSPVPYLSPETNPASSASAVKHNVNLTNVNLEEPTPAPPTSHVSQADCLGAPSPEAPHTMLRDEGVSLPSHVDPAKVYRKEPYPEEMMRQNHILKQPALGHPGQRLDKEPNPAYDPQLPYVEKQASRDLEQPPYRYESSSYTDQFSRNYDHRLRFEDRVPTYEDQWSYYDDKQPYPTRPFDTQHPRDLDSRQHPEEASERGYFQRFEEPAPLPYDSRPRYEQLPRTSTLRHEEQPTSGYEVHNRYRPEAQPYAPAGPKSSEPKQYFDQYPRSYEQVPPPGFTSKTGHYEPLHGAAVVPPLIPSSQHKPEVLPSATKPQPPPPALTEEEEDPAMKPQSVLTRVKMFENKRSASLENKKDVNDTASFKPPEVASKPPSASLVGPKPVSQTQFSEHDKTLYRLPEPQKPQAKPPEDIVRSNHYDPEEDEEYYRKQLSYFDRRSFESKPPAHIPAGHHSEPAKPVHSQSQPNFSSYSSKGKPETDAMDRSFSEKRYDPTQAMPPPPPLPSQYSQPVPPLSNSSLHIHSKAAQSEGNSVSLDFQNSYISKPDPPPSQSKPATFRPPTREDPPQTFYPQKSFPDKASVNGAEQTQKTITPAYNRFTPKPYTSSARPFERKFESPKFNHNLLPSETVHKPELSSKPPPSPKTLMKAHSSTQPPEFDSGVETFSVHTDKPKYQINNISTMPKAVPVSPSAVEEDEDEDGHTVVATARGIFNSNGGVLSSIETGVSIIIPQGAIPEGIEQEIYFKVCRDNSILPPLDKEKGETLLSPLVMCGPHGLKFLKPVELRLPHCDPKTWQNKCLPGDPNYLVGANCVSVLIDHF", "length": 1725, "header": "tr|F1M4A0-1|ZO1_RAT Computationally mapped isoform of Tight junction protein ZO-1 OS=Rattus norvegicus OX=10116 GN=Tjp1 PE=1 SV=3 CANONICAL=A0A0G2K2P5-1" }, "locus": { "chromosome": "1", "start_pos": 118899126, "end_pos": 118851242, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000014988.8", "url": "https://www.ensembl.org/id/ENSRNOT00000014988.8" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000014988.7", "url": "https://www.ensembl.org/id/ENSRNOP00000014988.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool": "isoglyp", "mining_tool": "", "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "start_pos": 960, "start_aa": "T", "end_pos": 960, "end_aa": "T", "residue": "Thr", "site_lbl": "Thr960", "evidence": [ { "id": "GLY_001157", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001157" } ], "filter_code": "00000000000000001000.00000000001000.1.01000" } ], "phosphorylation": [ { "start_pos": 1071, "end_pos": 1071, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2P5", "url": "https://www.uniprot.org/uniprot/A0A0G2K2P5" } ], "site_lbl": "Ser1071" }, { "start_pos": 1139, "end_pos": 1139, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2P5", "url": "https://www.uniprot.org/uniprot/A0A0G2K2P5" } ], "site_lbl": "Tyr1139" }, { "start_pos": 1164, "end_pos": 1164, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2P5", "url": "https://www.uniprot.org/uniprot/A0A0G2K2P5" } ], "site_lbl": "Tyr1164" }, { "start_pos": 125, "end_pos": 125, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2P5", "url": "https://www.uniprot.org/uniprot/A0A0G2K2P5" }, { "database": "PubMed", "id": "16641100", "url": "https://glygen.org/publication/PubMed/16641100" }, { "database": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" }, { "database": "iPTMnet", "id": "A0A0G2K2P5", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A0A0G2K2P5" } ], "site_lbl": "Ser125" }, { "start_pos": 132, "end_pos": 132, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2P5", "url": "https://www.uniprot.org/uniprot/A0A0G2K2P5" }, { "database": "PubMed", "id": "16641100", "url": "https://glygen.org/publication/PubMed/16641100" }, { "database": "iPTMnet", "id": "A0A0G2K2P5", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A0A0G2K2P5" } ], "site_lbl": "Tyr132" }, { "start_pos": 1353, "end_pos": 1353, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2P5", "url": "https://www.uniprot.org/uniprot/A0A0G2K2P5" } ], "site_lbl": "Tyr1353" }, { "start_pos": 1365, "end_pos": 1365, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2P5", "url": "https://www.uniprot.org/uniprot/A0A0G2K2P5" } ], "site_lbl": "Ser1365" }, { "start_pos": 1411, "end_pos": 1411, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2P5", "url": "https://www.uniprot.org/uniprot/A0A0G2K2P5" } ], "site_lbl": "Ser1411" }, { "start_pos": 1542, "end_pos": 1542, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2P5", "url": "https://www.uniprot.org/uniprot/A0A0G2K2P5" } ], "site_lbl": "Ser1542" }, { "start_pos": 1614, "end_pos": 1614, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2P5", "url": "https://www.uniprot.org/uniprot/A0A0G2K2P5" }, { "database": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" }, { "database": "iPTMnet", "id": "A0A0G2K2P5", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A0A0G2K2P5" } ], "site_lbl": "Ser1614" }, { "start_pos": 175, "end_pos": 175, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2P5", "url": "https://www.uniprot.org/uniprot/A0A0G2K2P5" }, { "database": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" }, { "database": "iPTMnet", "id": "A0A0G2K2P5", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A0A0G2K2P5" } ], "site_lbl": "Ser175" }, { "start_pos": 178, "end_pos": 178, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2P5", "url": "https://www.uniprot.org/uniprot/A0A0G2K2P5" }, { "database": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" }, { "database": "iPTMnet", "id": "A0A0G2K2P5", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A0A0G2K2P5" } ], "site_lbl": "Ser178" }, { "start_pos": 179, "end_pos": 179, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2P5", "url": "https://www.uniprot.org/uniprot/A0A0G2K2P5" } ], "site_lbl": "Ser179" }, { "start_pos": 185, "end_pos": 185, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2P5", "url": "https://www.uniprot.org/uniprot/A0A0G2K2P5" } ], "site_lbl": "Thr185" }, { "start_pos": 212, "end_pos": 212, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2P5", "url": "https://www.uniprot.org/uniprot/A0A0G2K2P5" }, { "database": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" }, { "database": "iPTMnet", "id": "A0A0G2K2P5", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A0A0G2K2P5" } ], "site_lbl": "Ser212" }, { "start_pos": 241, "end_pos": 241, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", 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molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia.", "journal": "J. Cell Biol.", "date": "1986", "authors": "Stevenson B R, Siliciano J D, Mooseker M S, Goodenough D A", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2P5", "url": "https://www.uniprot.org/uniprot/A0A0G2K2P5" } ], "reference": [ { "type": "PubMed", "id": "3528172", "url": "https://glygen.org/publication/PubMed/3528172" } ] }, { "title": "The gap junction protein connexin43 interacts with the second PDZ domain of the zona occludens-1 protein.", "journal": "Current biology : CB", "date": "1998", "authors": "Giepmans BN, Moolenaar WH", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2P5", "url": "https://www.uniprot.org/uniprot/A0A0G2K2P5" } ], "reference": [ { "type": "PubMed", "id": "9707407", "url": "https://glygen.org/publication/PubMed/9707407" } ] } ], "pathway": [ { "id": "R-RNO-191650", "name": "Regulation of gap junction activity", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-191650", "resource": "Reactome", "description": "Regulation of gap junction 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"length": 1855 }, "evidence": [ { "id": "A0A0G2K2P5", "url": "https://omabrowser.org/oma/group/A0A0G2K2P5/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "P39447-1", "protein_name": "Tight junction protein ZO-1", "gene_name": "Tjp1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSARAAAAKSTAMEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSHPDPEPVSDNEDDSYDEEVHDPRAGRGALANRRSEKSWARDRSASRERSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSANASERDDISEIQSLASDHSGRSHDRPPRRSQSRSPDQRSEPSDHSTQSPQQPSNGSLRSREEERMSKPGAISTPVKHVDDHPPKAVEEVTVEKNEKQTPTLPEPKPVYAQVGQPDVDLPVSPSDGALPNSAHEDGILRPSMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLEEGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIRTHFEYEKESPYGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQLASVQYTLPKTAGGDRADFWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREKLAREEPDIYQIAKSEPRDAGTDHRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSYLSAPGSEYSMYSTDSRHTSDYEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSEPVREDSSGMHHENQTYPPYSPQAQPQAIHRIDSPGLKPASQQKAEASSPVPYLSPETTPASSASAVNHNVSVTNVSLEEPAPAPPTSHASQPGCLGAPSAEAAHVVLRGEGPPLPPHADPAKVYRKEPYSEEMMRQNHILKQPALGHPGQRPDKEPNLAYEPQLPYIEKQASRDLEQPSYRYEVSSYTDQFSRNYDHRLRFEDRIPTYEDQWSYYDDKQPYQPRPFENQHPRDLDSRQHPEEASERGYFQRFEEPAPLSYDSRTRYEQLPRTSTLRHEEQPAPAYEVHNRYRPEAQPYSSTGPKSSEPKQYFDQYPRSYEQVPPPGFTSKTGHYEPLHGAAVVPPLIPSSQQKPEVLPSATKPQPPPPTLTEEEEDPAMKPQSVLTRVKMFENKRSASLENKKDVNDTASFKPPEVASKPPGASLAGPKPVPQSQFSEHDKTLYRLPEPQKPQVKPPEDIVRSNHYDPEEDEEYYRKQLSYFDRRSFESKPSAHLPAGHHSEPAKPVHSQSQPNFSSYSSKGKPETDAVDRSFSEKRYDPAQATPPPPPLPSQYSQPAPPLSSSSLHIHSKGAQGEGNSVSLDFQNSYMSKPDPPPSQSKPATFRPPTREDPPQTFYPQKSFPDKAPVNGAEQTQKTITPVYNRFTPKPYTSSARPFERKFESPKFNHNLLPSETVHKPELSSKTPTSPKTLMKAHSSTQPPEFDSGVETFSVHTDKPKYQMNNISTMPKAVPVSPSAVEEDEDEDGHTVVATARGIFNSNGGVLSSIETGVSIIIPQGAIPEGIEQEIYFKVCRDNSILPPLDKEKGETLLSPLVMCGPHGLKFLKPVELRLPHCDPKTWQNKCLPGDPNYLVGANCVSVLIDHF", "length": 1745 }, "evidence": [ { "id": "A0A0G2K2P5", "url": "https://omabrowser.org/oma/group/A0A0G2K2P5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q07157-1", "protein_name": "Tight junction protein ZO-1", "gene_name": "TJP1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSARAAAAKSTAMEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPDPEPVSDNEEDSYDEEIHDPRSGRSGVVNRRSEKIWPRDRSASRERSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSANASERDDISEIQSLASDHSGRSHDRPPRRSRSRSPDQRSEPSDHSRHSPQQPSNGSLRSRDEERISKPGAVSTPVKHADDHTPKTVEEVTVERNEKQTPSLPEPKPVYAQVGQPDVDLPVSPSDGVLPNSTHEDGILRPSMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLEEGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIRTHFEYEKESPYGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQLASVQYTLPKTAGGDRADFWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREKLAREEPDIYQIAKSEPRDAGTDQRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSYLSAPGSEYSMYSTDSRHTSDYEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSEPVREDSSGMHHENQTYPPYSPQAQPQPIHRIDSPGFKPASQQKAEASSPVPYLSPETNPASSTSAVNHNVNLTNVRLEEPTPAPSTSYSPQADSLRTPSTEAAHIMLRDQEPSLSSHVDPTKVYRKDPYPEEMMRQNHVLKQPAVSHPGHRPDKEPNLTYEPQLPYVEKQASRDLEQPTYRYESSSYTDQFSRNYEHRLRYEDRVPMYEEQWSYYDDKQPYPSRPPFDNQHSQDLDSRQHPEESSERGYFPRFEEPAPLSYDSRPRYEQAPRASALRHEEQPAPGYDTHGRLRPEAQPHPSAGPKPAESKQYFEQYSRSYEQVPPQGFTSRAGHFEPLHGAAAVPPLIPSSQHKPEALPSNTKPLPPPPTQTEEEEDPAMKPQSVLTRVKMFENKRSASLETKKDVNDTGSFKPPEVASKPSGAPIIGPKPTSQNQFSEHDKTLYRIPEPQKPQLKPPEDIVRSNHYDPEEDEEYYRKQLSYFDRRSFENKPPAHIAASHLSEPAKPAHSQNQSNFSSYSSKGKPPEADGVDRSFGEKRYEPIQATPPPPPLPSQYAQPSQPVTSASLHIHSKGAHGEGNSVSLDFQNSLVSKPDPPPSQNKPATFRPPNREDTAQAAFYPQKSFPDKAPVNGTEQTQKTVTPAYNRFTPKPYTSSARPFERKFESPKFNHNLLPSETAHKPDLSSKTPTSPKTLVKSHSLAQPPEFDSGVETFSIHAEKPKYQINNISTVPKAIPVSPSAVEEDEDEDGHTVVATARGIFNSNGGVLSSIETGVSIIIPQGAIPEGVEQEIYFKVCRDNSILPPLDKEKGETLLSPLVMCGPHGLKFLKPVELRLPHCDPKTWQNKCLPGDPNYLVGANCVSVLIDHF", "length": 1748 }, "evidence": [ { "id": "A0A0G2K2P5", "url": "https://omabrowser.org/oma/group/A0A0G2K2P5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 19, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2P5", "url": "https://www.uniprot.org/uniprot/A0A0G2K2P5" } ], "pmid": "" }, { "name": "bicellular tight junction", "id": "GO:0005923", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005923", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2P5", "url": "https://www.uniprot.org/uniprot/A0A0G2K2P5" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2P5", "url": "https://www.uniprot.org/uniprot/A0A0G2K2P5" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2P5", "url": "https://www.uniprot.org/uniprot/A0A0G2K2P5" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2P5", "url": "https://www.uniprot.org/uniprot/A0A0G2K2P5" } ], "pmid": "" }, { "name": "cell-cell junction", "id": "GO:0005911", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005911", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2P5", "url": "https://www.uniprot.org/uniprot/A0A0G2K2P5" } ], "pmid": "" }, { "name": "adherens junction", "id": "GO:0005912", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005912", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2P5", "url": "https://www.uniprot.org/uniprot/A0A0G2K2P5" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2P5", "url": "https://www.uniprot.org/uniprot/A0A0G2K2P5" } ], "pmid": "" }, { "name": "basolateral plasma membrane", "id": "GO:0016323", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016323", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2P5", "url": "https://www.uniprot.org/uniprot/A0A0G2K2P5" } ], "pmid": "" }, { "name": "cell junction", "id": "GO:0030054", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030054", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2P5", "url": "https://www.uniprot.org/uniprot/A0A0G2K2P5" } ], "pmid": "" }, { "name": "apical part of cell", "id": "GO:0045177", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045177", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2P5", "url": "https://www.uniprot.org/uniprot/A0A0G2K2P5" } ], "pmid": "" }, { "name": "intercalated disc", "id": "GO:0014704", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014704", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2P5", "url": "https://www.uniprot.org/uniprot/A0A0G2K2P5" } ], "pmid": "" }, { "name": "apical plasma membrane", "id": "GO:0016324", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016324", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2P5", "url": "https://www.uniprot.org/uniprot/A0A0G2K2P5" } ], "pmid": "" }, { "name": "intercellular canaliculus", "id": "GO:0046581", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046581", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2P5", "url": "https://www.uniprot.org/uniprot/A0A0G2K2P5" } ], "pmid": "" }, { "name": "gap junction", "id": "GO:0005921", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005921", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2P5", "url": "https://www.uniprot.org/uniprot/A0A0G2K2P5" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2P5", "url": "https://www.uniprot.org/uniprot/A0A0G2K2P5" } ], "pmid": "" }, { "name": "apical junction complex", "id": "GO:0043296", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043296", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2P5", "url": "https://www.uniprot.org/uniprot/A0A0G2K2P5" } ], "pmid": "" }, { "name": "tight junction", "id": "GO:0070160", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070160", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2P5", "url": "https://www.uniprot.org/uniprot/A0A0G2K2P5" } ], "pmid": "" }, { "name": "apicolateral plasma membrane", "id": "GO:0016327", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016327", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2P5", "url": "https://www.uniprot.org/uniprot/A0A0G2K2P5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 7, "go_terms": [ { "name": "connexin binding", "id": "GO:0071253", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071253", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2P5", "url": "https://www.uniprot.org/uniprot/A0A0G2K2P5" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2P5", "url": "https://www.uniprot.org/uniprot/A0A0G2K2P5" } ], "pmid": "" }, { "name": "protein domain specific binding", "id": "GO:0019904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019904", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2P5", "url": "https://www.uniprot.org/uniprot/A0A0G2K2P5" } ], "pmid": "" }, { "name": "transmembrane transporter binding", "id": "GO:0044325", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044325", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2P5", "url": "https://www.uniprot.org/uniprot/A0A0G2K2P5" } ], "pmid": "" }, { "name": "cell adhesion molecule binding", "id": "GO:0050839", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050839", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2P5", "url": "https://www.uniprot.org/uniprot/A0A0G2K2P5" } ], "pmid": "" }, { "name": "beta-catenin binding", "id": "GO:0008013", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008013", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2P5", "url": "https://www.uniprot.org/uniprot/A0A0G2K2P5" } ], "pmid": "" }, { "name": "kinase activity", "id": "GO:0016301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016301", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2P5", "url": "https://www.uniprot.org/uniprot/A0A0G2K2P5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 27, "go_terms": [ { "name": "positive regulation of sprouting angiogenesis", "id": "GO:1903672", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903672", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2P5", "url": "https://www.uniprot.org/uniprot/A0A0G2K2P5" } ], "pmid": "" }, { "name": "protein localization to cell-cell junction", "id": "GO:0150105", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0150105", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2P5", "url": "https://www.uniprot.org/uniprot/A0A0G2K2P5" } ], "pmid": "" }, { "name": "positive regulation of cell population proliferation", "id": "GO:0008284", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008284", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2P5", "url": "https://www.uniprot.org/uniprot/A0A0G2K2P5" } ], "pmid": "" }, { "name": "positive regulation of cell migration", "id": "GO:0030335", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030335", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2P5", "url": "https://www.uniprot.org/uniprot/A0A0G2K2P5" } ], "pmid": "" }, { "name": "response to lipopolysaccharide", "id": "GO:0032496", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032496", "evidence": [ { 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