{ "uniprot_canonical_ac": "A0A0G2K2M3-1", "uniprot_ac": "A0A0G2K2M3", "uniprot_id": "A0A0G2K2M3_RAT", "mass": { "chemical_mass": 95054.0, "monoisotopic_mass": 95054.0 }, "refseq": {}, "gene_names": [ { "name": "Stat6", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A0G2K2M3", "id": "A0A0G2K2M3" } ], "protein_names": [ { "name": "Signal transducer and activator of transcription", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2M3/entry#names_and_taxonomy", "id": "A0A0G2K2M3" } ], "function": [], "disease": [ { "disease_id": "DOID:0050855", "recommended_name": { "id": "DOID:0050855", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050855", "name": "renal fibrosis", "description": "A kidney disease that is characterized by progressive detrimental connective tissue deposition of the kidney parenchyma leading to deterioration of renal function." }, "synonyms": [], "evidence": [ { "id": "0050855", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0050855" } ] }, { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0700275", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0700275", "name": "prostate cancer, hereditary", "description": "An instance of prostate cancer that is caused by an inherited genomic modification in an individual. Familial prostate cancer (FPC) is a malignant tumor of the prostate with an early onset. FPC is either asymptomatic or causes mictionary symptoms, erectile dysfunction, bone pain, venous compression and infectious or inflammatory syndrome (for the metastatic forms). It is also characterized by familial antecedents." }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ], "evidence": [ { "id": "10283", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10283" } ] }, { "disease_id": "DOID:10286", "recommended_name": { "id": "DOID:10286", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10286", "name": "prostate carcinoma", "description": "A prostate cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells." }, "synonyms": [ { "id": "DOID:10286", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10286", "name": "cancer of prostate", "description": "" }, { "id": "DOID:10286", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10286", "name": "carcinoma of prostate", "description": "" } ], "evidence": [ { "id": "10286", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10286" } ] }, { "disease_id": "DOID:10966", "recommended_name": { "id": "DOID:10966", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10966", "name": "lipoid nephrosis", "description": "" }, "synonyms": [ { "id": "DOID:10966", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10966", "name": "Minimal Change Glomerulonephritis", "description": "" }, { "id": "DOID:10966", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10966", "name": "Minimal change disease", "description": "" }, { "id": "DOID:10966", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10966", "name": "Nephrotic syndrome with lesion of minimal change glomerulonephritis", "description": "" }, { "id": "DOID:10966", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10966", "name": "Nephrotic syndrome with lesion of minimal change nephrotic syndrome", "description": "" } ], "evidence": [ { "id": "10966", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10966" } ] }, { "disease_id": "DOID:1394", "recommended_name": { "id": "DOID:1394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1394", "name": "urinary schistosomiasis", "description": "A schistosomiasis that involves parasitic infection of the urinary tract caused by a digenetic trematode Schistosoma haematobium causing cystitis, ureteritis, fibrosis of the bladder and haematuria, which can progress to bladder cancer." }, "synonyms": [ { "id": "DOID:1394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1394", "name": "Schistosoma Hematobium Infection", "description": "" }, { "id": "DOID:1394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1394", "name": "Schistosoma haematobium", "description": "" }, { "id": "DOID:1394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1394", "name": "Schistosoma hematobium infectious disease", "description": "" }, { "id": "DOID:1394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1394", "name": "Schistosomiasis due to schistosoma haematobium", "description": "" }, { "id": "DOID:1394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1394", "name": "Schistosomiasis of bladder", "description": "" }, { "id": "DOID:1394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1394", "name": "Vesical schistosomiasis", "description": "" }, { "id": "DOID:1394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1394", "name": "bladder Schistosomiasis", "description": "" }, { "id": "DOID:1394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1394", "name": "cystitis with bilharziasis", "description": "" } ], "evidence": [ { "id": "1394", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1394" } ] }, { "disease_id": "DOID:1996", "recommended_name": { "id": "DOID:1996", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1996", "name": "rectum adenocarcinoma", "description": "A rectum cancer that derives_from epithelial cells of glandular origin." }, "synonyms": [ { "id": "DOID:1996", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1996", "name": "Rectal adenocarcinoma", "description": "" } ], "evidence": [ { "id": "1996", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1996" } ] }, { "disease_id": "DOID:234", "recommended_name": { "id": "DOID:234", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:234", "name": "colon adenocarcinoma", "description": "A colon carcinoma that derives_from epithelial cells of glandular origin." }, "synonyms": [ { "id": "DOID:234", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:234", "name": "Colonic adenocarcinoma", "description": "" }, { "id": "DOID:234", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:234", "name": "adenocarcinoma of colon", "description": "" } ], "evidence": [ { "id": "234", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:234" } ] }, { "disease_id": "DOID:2841", "recommended_name": { "id": "DOID:2841", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2841", "name": "asthma", "description": "A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. The disease has_symptom recurring periods of wheezing (a whistling sound while breathing), has_symptom chest tightness, has_symptom shortness of breath, has_symptom mucus production and has_symptom coughing." }, "synonyms": [ { "id": "DOID:2841", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2841", "name": "bronchial hyperreactivity", "description": "" }, { "id": "DOID:2841", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2841", "name": "chronic obstructive asthma", "description": "" }, { "id": "DOID:2841", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2841", "name": "chronic obstructive asthma with acute exacerbation", "description": "" }, { "id": "DOID:2841", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2841", "name": "chronic obstructive asthma with status asthmaticus", "description": "" }, { "id": "MONDO:0010940", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010940", "name": "inherited susceptibility to asthma", "description": "" }, { "id": "MONDO:0010940", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010940", "name": "asthma, nocturnal, susceptibility to", "description": "" }, { "id": "MONDO:0010940", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010940", "name": "asthma, bronchial", "description": "" }, { "id": "MONDO:0010940", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010940", "name": "asthma, diminished response to Antileukotriene treatment 1N", "description": "" }, { "id": "MONDO:0010940", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010940", "name": "asthma, protection against", "description": "" }, { "id": "MONDO:0010940", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010940", "name": "asthma, susceptibility to", "description": "" }, { "id": "MONDO:0010940", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010940", "name": "asthma-related traits, susceptibility to", "description": "" }, { "id": "MIM:600807", "resource": "MIM", "url": "https://www.omim.org/entry/600807", "name": "Asthma", "description": "Asthma" } ], "evidence": [ { "id": "2841", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:2841" } ] }, { "disease_id": "DOID:3717", "recommended_name": { "id": "DOID:3717", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3717", "name": "gastric adenocarcinoma", "description": "A stomach carcinoma that derives_from epithelial cells of glandular origin." }, "synonyms": [ { "id": "DOID:3717", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3717", "name": "adenocarcinoma of stomach", "description": "" }, { "id": "DOID:3717", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3717", "name": "stomach adenocarcinoma", "description": "" } ], "evidence": [ { "id": "3717", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:3717" } ] }, { "disease_id": "DOID:820", "recommended_name": { "id": "DOID:820", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:820", "name": "myocarditis", "description": "An extrinsic cardiomyopathy that is characterized as an inflammation of the heart muscle." }, "synonyms": [ { "id": "DOID:820", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:820", "name": "Myocardial inflammation", "description": "" } ], "evidence": [ { "id": "820", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:820" } ] }, { "disease_id": "DOID:898", "recommended_name": { "id": "DOID:898", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:898", "name": "autosomal dominant polycystic kidney disease", "description": "A polycystic kidney disease characterized by the presence of multiple cysts located_in the kidney resulting from ciliopathy that disrupts the function of primary cilium, inherited in an autosomal dominant fashion." }, "synonyms": [ { "id": "DOID:898", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:898", "name": "Congenital biliary ectasias", "description": "" }, { "id": "DOID:898", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:898", "name": "POLYCYSTIC KIDNEY AND HEPATIC DISEASE 1", "description": "" }, { "id": "DOID:898", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:898", "name": "ADPKD", "description": "" } ], "evidence": [ { "id": "898", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:898" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2M3", "url": "https://www.uniprot.org/uniprot/A0A0G2K2M3" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "gene": [ { "name": "Stat6", "url": "https://www.uniprot.org/uniprot/A0A0G2K2M3", "locus": { "chromosome": "7", "start_pos": 63498495, "end_pos": 63479642, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000025023", "url": "https://www.ensembl.org/id/ENSRNOG00000025023" } ] } } ], "crossref": [ { "id": "cd10377", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd10377", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd16850", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16850", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd16856", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16856", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000980", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000980", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001217", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001217", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008967", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008967", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012345", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012345", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013799", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013799", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013800", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013800", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013801", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013801", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015988", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015988", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028187", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028187", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035857", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035857", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036535", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036535", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036860", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036860", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048988", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048988", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "EPQMPAM", "url": "https://omabrowser.org/oma/group/EPQMPAM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR11801", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11801", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11801:SF48", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11801:SF48", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00017", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00017", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF01017", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01017", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF02864", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02864", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF02865", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02865", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF14596", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14596", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF21354", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21354", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-186763", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-186763", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-3249367", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3249367", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-6785807", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6785807", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "1309063", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1309063", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "A0A0G2K2M3", "url": "https://www.uniprot.org/uniprot/A0A0G2K2M3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2K2M3-1", "url": "https://www.uniprot.org/uniprot/A0A0G2K2M3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSLWSLVSKMSPEKLQRLYVDFPQHLRHLLAEWLENQPWEFLVGSDAFCYNMASALLSATVQRLQASAGEQGKGSSLLQHISTLESIYQRDPLKLVATIRQILQGEKKAVIEEFHHLPGPFHRKQEELKFTTALGRLQHRVRETRILRESLQQGTKTAQVSLKNLIDPPANGTGPSEDLATMLQGTVGDLEATQALVLKRIQIWKRQQQLAGNGTPFEESLAGLQERTVFPDNCPGPRCESLVEIYSQLQQEIGAASGELEPKTRASLISRLDEVLRTLVTSSFLVEKQPPQVLKTQTKFQAGVRFLLGLQFLGTSAKPPLVRADMVTEKQARELSLPQGSGAGVESTGEIMNNTVPLENSVPGNCCSALFKNLLLKKIKRCERKGTESVTEEKCAVLFSTSFMLGPNKHLIQLQALSLPLVVIVHGNQDNNAKATILWDNAFSEMDRVPFVVAERVPWEKMCETLNLKFMAEVGTSRGLLPEHFLFLAQKIFNDNSLSIEAFQHRCVSWSQFNKEILLGRGFTFWQWFDGVLDLTKRCLRSYWSDRLIIGFISKQYVTSLLLNEPDGTFLLRFSDSEIGGITIAHVIRGQDGSSQIENIQPFSAKDLSIRSLGDRIRDLAQLKNLYPKKPKDEAFRSHYKPEQMGKDGRGYVSTTIKMTVERDQPLPTPEPQMPAMVAPYDLGMAPDASMQLSSDMVYPPQSHSIHSFQSIPLEESMSVLPPFQEPHLQMPPTMSQISMPFDQPHPQGLLQCQSQEHAVSSPEPLLCSDVTMAEDSCLTQPVQGFPQGTWVSEGMYPPLMPPTEQDLTKLLLEGQGEGGGSIGTQPLLQPSSYGQSGISMSHLDLRTNPSW", "length": 852, "header": "tr|A0A0G2K2M3-1|A0A0G2K2M3_RAT Isoform 1 of Signal transducer and activator of transcription OS=Rattus norvegicus OX=10116 GN=Stat6 PE=1 SV=1 CANONICAL=A0A0G2K2M3-1" }, "isoforms": [ { "isoform_ac": "A0A0G2K2M3-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2M3/entry#A0A0G2K2M3-1", "sequence": { "sequence": "MSLWSLVSKMSPEKLQRLYVDFPQHLRHLLAEWLENQPWEFLVGSDAFCYNMASALLSATVQRLQASAGEQGKGSSLLQHISTLESIYQRDPLKLVATIRQILQGEKKAVIEEFHHLPGPFHRKQEELKFTTALGRLQHRVRETRILRESLQQGTKTAQVSLKNLIDPPANGTGPSEDLATMLQGTVGDLEATQALVLKRIQIWKRQQQLAGNGTPFEESLAGLQERTVFPDNCPGPRCESLVEIYSQLQQEIGAASGELEPKTRASLISRLDEVLRTLVTSSFLVEKQPPQVLKTQTKFQAGVRFLLGLQFLGTSAKPPLVRADMVTEKQARELSLPQGSGAGVESTGEIMNNTVPLENSVPGNCCSALFKNLLLKKIKRCERKGTESVTEEKCAVLFSTSFMLGPNKHLIQLQALSLPLVVIVHGNQDNNAKATILWDNAFSEMDRVPFVVAERVPWEKMCETLNLKFMAEVGTSRGLLPEHFLFLAQKIFNDNSLSIEAFQHRCVSWSQFNKEILLGRGFTFWQWFDGVLDLTKRCLRSYWSDRLIIGFISKQYVTSLLLNEPDGTFLLRFSDSEIGGITIAHVIRGQDGSSQIENIQPFSAKDLSIRSLGDRIRDLAQLKNLYPKKPKDEAFRSHYKPEQMGKDGRGYVSTTIKMTVERDQPLPTPEPQMPAMVAPYDLGMAPDASMQLSSDMVYPPQSHSIHSFQSIPLEESMSVLPPFQEPHLQMPPTMSQISMPFDQPHPQGLLQCQSQEHAVSSPEPLLCSDVTMAEDSCLTQPVQGFPQGTWVSEGMYPPLMPPTEQDLTKLLLEGQGEGGGSIGTQPLLQPSSYGQSGISMSHLDLRTNPSW", "length": 852, "header": "tr|A0A0G2K2M3-1|A0A0G2K2M3_RAT Isoform 1 of Signal transducer and activator of transcription OS=Rattus norvegicus OX=10116 GN=Stat6 PE=1 SV=1 CANONICAL=A0A0G2K2M3-1" }, "locus": { "chromosome": "7", "start_pos": 63497522, "end_pos": 63484256, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000085350.2", "url": "https://www.ensembl.org/id/ENSRNOT00000085350.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000072301.2", "url": "https://www.ensembl.org/id/ENSRNOP00000072301.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool": "isoglyp", "mining_tool": "", "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "start_pos": 669, "start_aa": "T", "end_pos": 669, "end_aa": "T", "residue": "Thr", "site_lbl": "Thr669", "evidence": [ { "id": "GLY_001157", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001157" } ], "filter_code": "00000000000000001000.00000000001000.1.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-RNO-186763", "name": "Downstream signal transduction", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-186763", "resource": "Reactome", "description": "Downstream signal transduction" }, { "id": "R-RNO-3249367", "name": "STAT6-mediated induction of chemokines", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3249367", "resource": "Reactome", "description": "STAT6-mediated induction of chemokines" }, { "id": "R-RNO-6785807", "name": "Interleukin-4 and Interleukin-13 signaling", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6785807", "resource": "Reactome", "description": "Interleukin-4 and Interleukin-13 signaling" } ], "orthologs": [ { "uniprot_canonical_ac": "E5F1H4-1", "protein_name": "Signal transducer and activator of transcription", "gene_name": "STAT6", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSLWGLVSKMPPEKLQRLYVDFPQHLRHLLGDWLENQPWEFLVGSDAFCCNMASALLSATVQRLQALAGEQGEGSTILQHISTLESIYQRDPLKLVATFRHILQGEKKAVMEQFRHLPMPFHWKQEELKFNTILRRLQHRVGETRLLRKALQPGAEAGQVSLHNLLETPAKGTGPSEALATLLQETVGELEAAQALVLKRIQIWKRQQQLAGNGAPFEESLAPLQERCESLVDIYSQLQQEVGAAGGELEPKTRAALISRLDEVLQTLVTSSFLVEKQPPQVLKTQTKFQAGVRFLLGLRFLGAPAKPPLVRADMVTEKQARELSMPQGPGAGAESTGEIINNSVPLENSVPGNCCSALFKNLLLKKIKRCERKGTESVTEEKCAVLFSTSFVLGPNKLPIQLQALSLPLVVIVHGNQDNNAKATILWDNAFSEMDRVPFVVAERVPWEKMCETLNLKFMAEVGTNRGLLPEHFLFLAQKIFNDNSLSMEAFQHRSVSWSQFNKEILLGRGFTFWQWFDGVLDLTKRCLRSYWSDRLIIGFISKQYVTSLLLNEPDGTFLLRFSDSEIGGITIAHVIRGQDGSPQIENIQPFSAKDLSIRSLGDRIRDLAQLKNLYPKKPKDEAFRSHYKPEQMGKDGRGYVPATIKMTVERDQPLPTPEPQMPTMVPTYDLGMAPDTSMNMQLSPDMVSQMYPPHSHSIPSYPAIPREESVSVLSAFQEPHLQMPPNLSQMGLPFDQPHPQGLLPCQPQEHAVSSPEPLLCPDVTMAEESCLSQPVGGFPQGTWVGEDMFPPLLPPTEQDLTKLLLEGQGESGGGSLGAQPLLQPSLYGQSGISMSHLDLRANPSW", "length": 847 }, "evidence": [ { "id": "A0A0G2K2M3", "url": "https://omabrowser.org/oma/group/A0A0G2K2M3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F1MGJ4-1", "protein_name": "Signal transducer and activator of transcription", "gene_name": "STAT6", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MSLWGLVSKMPPEKLQRLYVDFPQHLRHLLGDWLENQPWEFLVGSDTFCCNMASALLSATVQRLQASAGEQGEGNTILQHISTLETIYQRDPLKLVATCRHILQGEKKAVMEQFHHLPMSFHWKQEELKFNTVLRRLQHRAGETRLLREALQPGAEAGQVSLHSLIETPTNGTGPSEALVTLLQETVGELEAAQALVLKRIQIWKRQQQLAGNGAPFEESLAPLQERCESLVDIYSQLQQEVGAAGGELDPKTRAALISRLDEVLRTLVTSSFLVEKQPPQVLKTQTKFQAGVRFLLGLRFLGAPAKPPLVRADMVTEKQARELSMPQGPGAGAESTGEIINNTVPLENSIPGNCCSALFKNLLLKKIKRCERKGTESVTEEKCAVLFSTSLTLGPNKLPIQLQALSLPLVVIVHGNQDNNAKATILWDNAFSEMDRVPFVVAERVPWEKMCETLNLKFMAEVGTNRGLLPEHFLFLAQKIFNDNSLSIEAFQHRSVSWSQFNKEILLGRGFTFWQWFDGVLDLTKRCLRSYWSDRLIIGFISKQYVTSLLLNEPDGTFLLRFSDSEIGGITIAHVIRGQDGSPQIENIQPFSAKDLSIRSLGDRIRDLAQLKNLYPKKPKDEAFRSHYKPEQMGKDGRGYVPATIKMTVERDQPLPTPEPQMPTMVPSYDLGMAPDSSMNLQLGPDMVPQVYPPRSHSIPSYPALPREESVNMLPAFQEPHLPMPPNLSQMSLPFDQPHPQGLLPCPPQDHAVSSPEPLLCSDVTMAEDSCLNQPVGGFPQGTWVREDMFPPLLPPTEQDLTKLLLEGQGESGGGSLGPQPLLQPSPYGQSGISMSHLDLRANPSW", "length": 847 }, "evidence": [ { "id": "A0A0G2K2M3", "url": "https://omabrowser.org/oma/group/A0A0G2K2M3/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "P42226-1", "protein_name": "Signal transducer and activator of transcription 6", "gene_name": "STAT6", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": 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