{ "uniprot_canonical_ac": "A0A0G2K261-1", "uniprot_ac": "A0A0G2K261", "uniprot_id": "A0A0G2K261_RAT", "mass": { "chemical_mass": 109987.0, "monoisotopic_mass": 109987.0 }, "refseq": {}, "gene_names": [ { "name": "Iars2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A0G2K261", "id": "A0A0G2K261" } ], "protein_names": [ { "name": "isoleucine--tRNA ligase", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K261/entry#names_and_taxonomy", "id": "A0A0G2K261" }, { "name": "6.1.1.5", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K261/entry#names_and_taxonomy", "id": "A0A0G2K261" }, { "name": "Isoleucyl-tRNA synthetase", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K261/entry#names_and_taxonomy", "id": "A0A0G2K261" } ], "function": [], "disease": [ { "disease_id": "DOID:700", "recommended_name": { "id": "DOID:700", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:700", "name": "mitochondrial metabolism disease", "description": "An inherited metabolic disorder that involves mitochondrial metabolism dysfunction." }, "synonyms": [], "evidence": [ { "id": "700", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:700" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K261", "url": "https://www.uniprot.org/uniprot/A0A0G2K261" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "gene": [ { "name": "Iars2", "url": "https://www.uniprot.org/uniprot/A0A0G2K261", "locus": { "chromosome": "13", "start_pos": 96831484, "end_pos": 96865501, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000002368", "url": "https://www.ensembl.org/id/ENSRNOG00000002368" } ] } } ], "crossref": [ { "id": "A0A0G2K261", "url": "https://alphafold.ebi.ac.uk/entry/A0A0G2K261", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSRNOG00000002368", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000002368", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07960", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07960", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "A0A0G2K261", "url": "https://www.ebi.ac.uk/intact/interactors/id:A0A0G2K261*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR001412", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001412", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002300", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002300", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002301", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002301", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009008", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009008", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009080", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009080", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013155", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013155", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014729", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014729", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023585", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023585", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033708", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033708", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050081", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050081", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "HCWRCKT", "url": "https://omabrowser.org/oma/group/HCWRCKT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR42765", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42765", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR42765:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42765:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00133", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00133", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF08264", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08264", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-9837999", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9837999", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "1311857", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1311857", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "A0A0G2K261", "url": "https://www.uniprot.org/uniprot/A0A0G2K261", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2K261-1", "url": "https://www.uniprot.org/uniprot/A0A0G2K261-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D4A8P9", "url": "https://www.uniprot.org/uniprot/D4A8P9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D4A8P9-1", "url": "https://www.uniprot.org/uniprot/D4A8P9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLWGLHPHGPGTAALTAAGSLWGPARFPSRLGCLGMTRRLVVRSVAGADSPQSSPKSGRYRDTVLLPQTNFPMKLLGHQQSDMELEIQQKCGFSELYSWQRERKVKTEFCLHDGPPYANGDPHVGHALNKILKDIVNRFHMMRGSKVHFVPGWDCHGLPIETKVLSELGVNTQTLSAMEIREKARSFAQAAIEKQKSAFARWGVMADWSNCYYTFDPKYEAKQLRVFQQMYEKGLVYRSYKPVYWSPSSRTALAEAELEYNPEHVSRSVYVRFPLLKPPPTLESLTGASSPVSALVWTTQPWTVPANQAICYMPEAKYAVVKCSASGNFYILAEDKISPVASALETTFDVTATFSGVDLEGGTCSHPLIPDKVSPLLPATHVTMAKGTGLVHTAPAHGMEDYSVASQHSLPMDCLVDEEGMFTSAAGPELQNKAVLTEGTDVVIKMLQATKNLLKEESIVHSYPCDWRTKKPVLIRASKQWFVNIMDIKATAKESLKTVKFIPGAALNSMMDMLDRRPYWCISRQRVWGVPIPVFHHKTKDEYLINSQTTEHIIKLVEQHGSDVWWTLPAEKLLPEEVVAQAGGPGALEYVPGQDILDIWFDSGTSWSCVLQGTEQRADLYLEGKDQLGGWFQSSLLTSVATRSKAPFRTVMVHGFTLGEKGEKMSKSLGNVIDPDTIISGGKDHSKEPPYGADILRWWIAESNVFTEVTIGPSVLSAARDDISKLRNTLRFLLGNLAGFNPETASVPVKNMYIIDQYMLHLIQDFATKVTDSYKQYDFGKVVRLLKAFYTRELSSFYFSIVKDRLYCESETDPKRRSCQTALAEILDVLVRSFAPVLPHLAEEVFQHIPYVKEPKSVFRTGWISTSSVWKKPGLEEAVESACAMRDSFLGSIPGKNAAEYDVIIVIEPGLLFEIMEMLQAEETSSTSQLNELMMASQTTLLAQEPRERSADAIELTGTFVINLEGQNLTRVRIVEGRRALGRSVQ", "length": 986, "header": "tr|A0A0G2K261-1|A0A0G2K261_RAT Isoform 1 of isoleucine--tRNA ligase OS=Rattus norvegicus OX=10116 GN=Iars2 PE=1 SV=2 CANONICAL=A0A0G2K261-1" }, "isoforms": [ { "isoform_ac": "A0A0G2K261-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K261/entry#A0A0G2K261-1", "sequence": { "sequence": "MLWGLHPHGPGTAALTAAGSLWGPARFPSRLGCLGMTRRLVVRSVAGADSPQSSPKSGRYRDTVLLPQTNFPMKLLGHQQSDMELEIQQKCGFSELYSWQRERKVKTEFCLHDGPPYANGDPHVGHALNKILKDIVNRFHMMRGSKVHFVPGWDCHGLPIETKVLSELGVNTQTLSAMEIREKARSFAQAAIEKQKSAFARWGVMADWSNCYYTFDPKYEAKQLRVFQQMYEKGLVYRSYKPVYWSPSSRTALAEAELEYNPEHVSRSVYVRFPLLKPPPTLESLTGASSPVSALVWTTQPWTVPANQAICYMPEAKYAVVKCSASGNFYILAEDKISPVASALETTFDVTATFSGVDLEGGTCSHPLIPDKVSPLLPATHVTMAKGTGLVHTAPAHGMEDYSVASQHSLPMDCLVDEEGMFTSAAGPELQNKAVLTEGTDVVIKMLQATKNLLKEESIVHSYPCDWRTKKPVLIRASKQWFVNIMDIKATAKESLKTVKFIPGAALNSMMDMLDRRPYWCISRQRVWGVPIPVFHHKTKDEYLINSQTTEHIIKLVEQHGSDVWWTLPAEKLLPEEVVAQAGGPGALEYVPGQDILDIWFDSGTSWSCVLQGTEQRADLYLEGKDQLGGWFQSSLLTSVATRSKAPFRTVMVHGFTLGEKGEKMSKSLGNVIDPDTIISGGKDHSKEPPYGADILRWWIAESNVFTEVTIGPSVLSAARDDISKLRNTLRFLLGNLAGFNPETASVPVKNMYIIDQYMLHLIQDFATKVTDSYKQYDFGKVVRLLKAFYTRELSSFYFSIVKDRLYCESETDPKRRSCQTALAEILDVLVRSFAPVLPHLAEEVFQHIPYVKEPKSVFRTGWISTSSVWKKPGLEEAVESACAMRDSFLGSIPGKNAAEYDVIIVIEPGLLFEIMEMLQAEETSSTSQLNELMMASQTTLLAQEPRERSADAIELTGTFVINLEGQNLTRVRIVEGRRALGRSVQ", "length": 986, "header": "tr|A0A0G2K261-1|A0A0G2K261_RAT Isoform 1 of isoleucine--tRNA ligase OS=Rattus norvegicus OX=10116 GN=Iars2 PE=1 SV=2 CANONICAL=A0A0G2K261-1" }, "locus": { "chromosome": "13", "start_pos": 96865421, "end_pos": 96832149, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000090786.2", "url": "https://www.ensembl.org/id/ENSRNOT00000090786.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000072118.2", "url": "https://www.ensembl.org/id/ENSRNOP00000072118.2" } ] } }, { "isoform_ac": "D4A8P9-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K261/entry#D4A8P9-1", "sequence": { "sequence": "MLWGLHPHGPGTAALTAAGSLWGPARFPSRLGCLGMTRRLVVRSVAGADSPQSSPKSGRYRDTVLLPQTNFPMKLLGHQQSDMELEIQQKCGFSELYSWQRERKVKTEFCLHDGPPYANGDPHVGHALNKILKDIVNRFHMMRGSKVHFVPGWDCHGLPIETKVLSELGVNTQTLSAMEIREKARSFAQAAIEKQKSAFARWGVMADWSNCYYTFDPKYEAKQLRVFQQMYEKGLVYRSYKPVYWSPSSRTALAEAELEYNPEHVSRSVYVRFPLLKPPPTLESLTGASSPVSALVWTTQPWTVPANQAICYMPEAKYAVVKCSASGNFYILAEDKISPVASALETTFDVTATFSGVDLEGGTCSHPLIPDKVSPLLPATHVTMAKGTGLVHTAPAHGMEDYSVASQHSLPMDCLVDEEGMFTSAAGPELQNKAVLTEGTDVVIKMLQATKNLLKEESIVHSYPCDWRTKKPVLIRASKQWFVNIMDIKATAKESLKTVKFIPGAALNSMMDMLDRRPYWCISRQRVWGVPIPVFHHKTKDEYLINRCVLLSPSLLALSVSL", "length": 562, "header": "tr|D4A8P9-1|A0A0G2K261_RAT Computationally mapped isoform of isoleucine--tRNA ligase OS=Rattus norvegicus OX=10116 GN=Iars2 PE=1 SV=4 CANONICAL=A0A0G2K261-1" }, "locus": { "chromosome": "13", "start_pos": 96865421, "end_pos": 96853329, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000057395.5", "url": "https://www.ensembl.org/id/ENSRNOT00000057395.5" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000054206.5", "url": "https://www.ensembl.org/id/ENSRNOP00000054206.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-RNO-9837999", "name": "Mitochondrial protein degradation", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9837999", "resource": "Reactome", "description": "Mitochondrial protein degradation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A480QG80-1", "protein_name": "isoleucine--tRNA ligase", "gene_name": "IARS2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRWGLRPSGPGAAALAAARNLWVQPRPSCRPSWRGTTGRLSVRSVTGASNQLQNSRNGSYRDTVLLPQTSFPMKLLGSQQPDTELEIQQKCGFSELYSWQRERKAKTEFCLHDGPPYANGDPHVGHALNKILKDIANRYHMMRGSKIHFVPGWDCHGLPIEIKVLSELGGKAQNLSAMEIREKARSFAKAAIEKQKSAFIRWGIMADWDNCYYTFDGKYEARQLRIFYQMYDKGLIYRSYKPVYWSPSSRTALAEAELEYNPEHVSRSVYVKFPLLKPSPKLASLIDGSSPVSFLVWTTQPWTIPANQAVCYMPESKYAVVKCSKSGDFYILAADKVTSVASTLGTTFEVISTFSGVDLESGTCTHPLIAERASPLLPANHVTMTKGTGLVHTAPAHGMEDYSVASQHSLSTDCLVNEDGVFTDAAGPELQNKAVLEEGTEVVIKMLQAANNLLKEEELVHSYPYDWRTKKPVVIRASKQWFVNITDVKTTAKDLLKKVKFIPESALNAMVDMMDRRPYWCISRQRVWGVPIPVFHHKTKDEFLINSQTVEHIAKLVEEHGSDIWWTLPSEQLLPKEVLSQVGGPDALEYVPGRDILDIWFDSGTSWSYVLPGTDQRADLYLEGKDQLGGWFQSSLLTSVAARRKSPFKTVVVHGFTLGEKGEKMSKSLGNVIDPDVVINGGQDQSKEPPFGADVLRWWVAESNVFTEVTISPSVLRAARDDVSKLRNTLRFLLGNVAGFNPETDSVPVNDMYVIDQYMLHLLQDLANKVTDAYKQYDFGKVVRLLRAFYTRELSTFYFSIIKDRLYCENAKDPKRRSCQTALAEILDVLVRSFAPILPHLAEEVFQYVPYAKEPKSVFRTGWIKTSPIWKKPGLEEAIEGACAMRDSFLGSIPGKNAAEYEVILVIEPGLLFEIIEMLQAEETSSTSQLNELMMASQTTLLPREPRTLTPDVMERRGTFLINLEGGDIREESAYKVIVMPTTKEKCPRCWKHTAASADALCPRCADVVGGQ", "length": 1012 }, "evidence": [ { "id": "A0A0G2K261", "url": "https://omabrowser.org/oma/group/A0A0G2K261/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3MWG4-1", "protein_name": "isoleucine--tRNA ligase", "gene_name": "IARS2", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MRWGLRPRGPGAAALAAAWNLWVPPRLPCRPLWRGTTGSLLVRSVTGASNQPQNSSNGSYRDTVLLPQTSFPMKLLGRQQPDTELEIQQKCGFSELYSWQRERKVKAEFCLHDGPPYANGDPHVGHALNKILKDIANRYHMMRGSKIHFVPGWDCHGLPIEIKVLSELGGKAQNLSAMEIREKARSFAKAAIEKQKLSFIRWGIMADWNNCYYTFDGRYEAKQLRIFYQMYDKGLIYRSYKPVFWSPSSRTALAEAELEYNPEHISRSVYVKFPLLKPSPKLASLLDGSSPVSFLVWTTQPWTIPANQAVCYMPESKYAVVKCSSSGDLYILGADKVTSVASTLGTTFEVISTFSGVDLENGSCAHPLISERESPLLPANHVTMTKGTGLVHTAPAHGMEDYSVAAQHNLSTDCLVNEDGVFTDAAGPELQNKAVLKEGTDAVIMMLQAAKNLLKEEKLVHSYPYDWRTKKPVVIRASKQWFVNITDIKTTAKELLKKVKFIPGSALNAMVEMMDRRPYWCISRQRVWGVPIPVFHHKTKDDVLINSQTIEHIIQLVEEHGSDIWWTLPPEQLLPKEVLSQVGGPDALEYVPGQDILDIWFDSGTSWSNVLPGTDQRADLYLEGKDQLGGWFQSSLLTSVAARNKSPFKTVVVHGFTLGEKGEKMSKSLGNIIDPDVVINGGQDHSKEPPYGADVLRWWVAESNVFTEVTISPSLLNAARDDISKLRNTLRFLLGNVAGFNPETDSIPVNSMYVIDQYMLHLLQDLANKINDSYKQYDFGKVVRLLQAFYTRELSNFYFSIIKDRLYCENADDPKRRSCQTALAEILDVMVRSFAPILPHLAEEVFQHIPYIKEPKSVFRTGWIKTSSIWKKPGLEEAIESACAMRDSFLGSIPGKNAAEYEVIIVIEPGLLFEIMEMLQAEETSSTSQLNELMMASQTTLLSQEPRGISEDVTELKGTFLINLEGGDIREESSYKVIVMTTTKEKCPRCWKYTAESSDTLCPRCAEVVKGK", "length": 1012 }, "evidence": [ { "id": "A0A0G2K261", "url": "https://omabrowser.org/oma/group/A0A0G2K261/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "Q54CE4-1", "protein_name": "Probable isoleucine--tRNA ligase, mitochondrial", "gene_name": "mileS", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MISLNNSFFNKRVIVNSFNNYKRSFGTKSQNEESAIVDSNHSFAHTLNLPKTTFSMKANAATREPTLLKDPYKLYKWQLENNKGENWVFHDGPPYANGDLHMGHALNKILKDIVNRYKVLKGFKVNYIPGWDCHGLPIEQQAFKKLKKSSDMKASDIRKIAGDFARKEIEKQSKGFQEMGILGDWENPYKTLDYGYEVEQIQTFYDMFNKGYIYRGVKPVHWSPSSRTALADAELEYNNNHTSKSIFVKFNVKSLSNHILNNLPTTSDINKAEMVISAIIWTTTPWTIPANQAICVNSEMDYILVKPIESEQYRNEMFIISKERLESLTKSFNIGELKVILEFKGEQLKGTITKHPQYDRESPIITGDHVIEGSGTGLVHTAPGHGVEDFQICQQQYPDLKVLSPVNDLGCFTDEVGEKFVGLEVLGDGNEAVINDLETIGSLLHKEDYIHKYPYDWRTKKPIIIRTTLQWFVGLKNIQKTALQSIERVNMVPPSGSNRLSSMIGKRTDWCISRQRVWGCPIPVLYNCKTNEPLINDESINHIKELFGKFGSDCWFEMSTQQLLPPSLKDQHENFVKGTDTMDVWFDSGTSWRGVLVERGIIDKDTGRADIYLEGSDQHRGWFQSSLLTSVCVRDIEPYKNVVTHGFLLDESGIKMSKSIGNTIVPSTVIKGGPNKVQNPPYGVDLLRTWVASSDYSKDISIGPNILIKILDGIKKIRNTLRFMLASNFDFDPTIHAIPYEKLSSLDKYALHRVFKLQESVTRHYDQFQFQKVHTEIINFSIEISSFYFDVIKRHLYAESPNSHSRRSTQTVLFKMLDVINIALAPITVHTSEDVFLHQYQFKNNGKGLDKNLIENSVFAHGWDQLPSQYENELISNQFTNIIAIRDVVNRVLQSMRSQGIIGRSDETIMELTVTNEESSPFYDNLFAINSQLDDIFCVSNVLLKKFNTFEKDVEQQQQQQQQQQQQQPQQIEPNSKGEFIFNTIISNNSKQLGRIEVLLKISDKFKCPRCWRHTSIENDKVCKPCDSVLNSLK", "length": 1034 }, "evidence": [ { "id": "A0A0G2K261", "url": "https://omabrowser.org/oma/group/A0A0G2K261/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q5ZKA2-1", "protein_name": "Isoleucine--tRNA ligase, mitochondrial", "gene_name": "IARS2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MLGAWRAAPRLRLRARFGVASVWARSAASEANSRRPAEESRQDSQYRDTVLLPHSRFAAQLPGRLQPDTELETQQKSGFLELYSWQRQRKAKQEFCLHDGPPYANGDPHVGHALNKILKDITNRFHMMRGYKVHYVPGWDCHGLPIELKALSEVKGAENLSPVEIRQKAKEFAERAIEKQKAAFIRWGIMADWANCYRTFDPKYEANQLRVFHKMYDKGFIYQDYKPVFWSPSAKTALAEAELEYNEQHVSRSVYMKFPLLKSPPKLASVIDGSSPASVLVWTTQPWTVPANQAVCYMPDAEYSVVKCATTGEHLILAADRVESTAAVLDTQFEVISTCKGVDLADGSCAHPTIAGRVSPLLPANHVTMTKGTGLVHTAPAHGMEDYNVASHHQLPTECLVDESGHFTEAAGPELKNKNVLEEGNEAVIKMLQAAGSLLKEEKYVHSYPYDWRTKKPMIIRASKQWFVNTANVKATAQEALKKVKIIPTSAVNRMLEMLDRRTFWCISRQRCWGVPIPVFYQKDTGESLINSETIADVIKIVEQQGTDAWWTLPIEQLLSKEAVAKAGGHNVLDYVKGQDVLDIWFDSGTSWAHVLEGAEQRADVYLEGKDQLGGWFQSSLLTSVATRKKAPYKTLVVHGFTLGEKGEKMSKSIGNVVDPDVVINGGDDHTKDPPYGADVLRWWVAESNVFTEVLIGPVVLNAARDDINKLRNTLRFMLGNMAGFNPETDSIPPSEMYIVDQYMLHLLQDYGSKVTEAYKEYDYSKVVRLLQAFCSRNLSNFYFSIIKDRLYCEEEKDPKRRSCQTVLAEALDVVVRSFAPILPHLAEEVFQHLPYKKDSEGVFRTGWINASSGWKKPGIEEAIEGACAMRDSFLGSISGKNALEYEVIIVIEPGLLFELMEALQAEESSRVSQLNEIMMASQTTLLSEIPKETPADANIVKGNFLINLEGGDIREESSYQVIALPTTKAKCPRCRRYTSDSSSTPCPRCLKVIAGKGST", "length": 1000 }, "evidence": [ { "id": "A0A0G2K261", "url": "https://omabrowser.org/oma/group/A0A0G2K261/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q8BIJ6-1", "protein_name": "Isoleucine--tRNA ligase, mitochondrial", "gene_name": "Iars2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MHWGLCPRGPGAAAVAAAGSFWGPARLPSRLGCLGMTRRLVVRSVAGADSPQSSSKGGRYRDTVLLPQTSFPMKLLGRQQSDMELEIQQKCGFSELYSWQRERKVKTEFCLHDGPPYANGDPHVGHALNKILKDIANRFHMMRGSKVHFVPGWDCHGLPIETKVLSELGVDAQSLSAMEIREKARSFAQAAIEKQKSAFVRWGVMADWNNCYYTFDPKYEAKQLRVFYQMYEKGLVYRSYKPVYWSPSSRTALAEAELEYNPEHVSRSIYVRFPLLRPPPKLESLTDASSPVSVLVWTTQPWTIPANQAICYMPEAKYAVVKCSASGHLYILAEDKIAPVASALETTFDVVAAFSGVDLEGGTCSHPLTPDKVSPLLPATHVTMAKGTGLVHTAPAHGMEDYSVASQHSLPMDCLVDEGGMFTDAAGPELQNKAVLKEGTDVVIKMLQATKNVLKEENIVHSYPCDWRTKTPVLIRASKQWFVNITDIKAAAKESLKTVKFIPGAALNSMTDMLDRRPYWCISRQRVWGVPIPVFHHKTKDEYLINSQTTEHIIKLVEQHGSDVWWTLPAEQLLPAEVLAQAGGPGALEYAPGQDILDIWFDSGTSWSCVLQDTQQRADLYLEGKDQLGGWFQSSLLTSVATRSKAPFRTVMVHGFTLGEKGEKMSKSLGNVINPDTIISGGKDHSKEPPYGADILRWWIAESNVFTEVTIGPSVLSAARDDISKLRNTLRFLLGNLTGFNPETDSVPVKNMYVIDQYMLHLIQDFATKITDSYKQYDFGKVVRLLKAFYTRELSSFYFSIVKDRLYCENEKDPKRRSCQTALAEILDVLVRAFAPILPHLAEEVFQHIPYVTEPKSVFRTGWINTSSIWKKPGLEEAVESACAMRDSFLGSIPGKNAAEYEVIIVIEPGLLFEIMEMLQAEETSSTSQLNELMMASQTTLLAQEPRERTAGDIELTGTFVINLEGGDIREESSYKVIVVPTAREKCPRCWKHTSETADALCPRCAEVIGAK", "length": 1012 }, "evidence": [ { "id": "A0A0G2K261", "url": "https://omabrowser.org/oma/group/A0A0G2K261/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8RXK8-1", "protein_name": "Isoleucine--tRNA ligase, chloroplastic/mitochondrial", "gene_name": "OVA2", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MSSFFKSFAGNPREAAAMAMVQSSSYRVLSGKSCSNLRRNTPLDSFLAKGRSSVKAFSFLYVSRFSTEPNNEFGHSSKRRSRGPVMAAKKASEGEKQEDGKYKQTVDLPKTGFGMRANSLTREPELQKLWEENQVFKRVSDNNNGGSFILHDGPPYANGDLHMGHALNKILKDIINRYKLLQNYKVQYVPGWDCHGLPIELKVLQSLDQEVRKELTPLKLRAKAAKFAKATVKTQMESFKRFGVWADWNNPYLTLDPEYEAAQIEVFGQMALKGYIYRGRKPVHWSPSSRTALAEAELEYPEGHISKSIYAIFKLVGGAKTSLLDEFIPNIYLAVWTTTPWTMPANAAVAVNAKLQYSVVEVQSFSEDESTVTSNKKKIPGKVLKNQQKLFVIVATDLVPALEAKWGVKLSISKTFLGSDLENCRYTHPIDNRDCPVVIGGDYITTESGTGLVHTAPGHGQEDYATGLKYGLPLVSPVDDEGKFTEEAGQFRGLSVLGEGNTAVVSYLDENMSLVMEESYAHKYPYDWRTKKPTIFRATEQWFASVEGFRTATMDAINNVKWVPHQAVNRISAMTSSRSDWCISRQRTWGVPIPAFYHVKTKEPLMNEETINHVKSIISQKGSDAWWYMSVEDLLPEKYRDKAADYEKGTDTMDVWFDSGSSWAGVLGKREGLSFPADVYLEGTDQHRGWFQSSLLTSIATQGKAPYSAVITHGFVLDEKGMKMSKSLGNVVDPRLVIEGGKNSKDAPAYGADVMRLWVSSVDYTGDVLIGPQILRQMSDIYRKLRGTLRYLLGNLHDWRVDNAVPYQDLPIIDQHALFQLENVVKNIQECYENYQFFKIFQIIQRFTIVDLSNFYFDIAKDRLYTGGTSSFTRRSCQTVLSTHLLSILRVIAPIVPHLAEDVWQNLPFEYRNEDGSAAEFVFELKWPTLNEQWLSFPAEDVLFWQRLLELRTEVNKVLELARNEKMIGSSLEAKVYLHTADAGMAAKLLEMSEAKNEADTLQRIFITSQVEVLSSMEKEMISSVQHTGEYVEGENKVWIGVSRAEGSKCERCWNYSGQVGSFSDHPTLCGRCFSVIVANPPEPAVAAVNSLA", "length": 1093 }, "evidence": [ { "id": "A0A0G2K261", "url": "https://omabrowser.org/oma/group/A0A0G2K261/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9NSE4-1", "protein_name": "Isoleucine--tRNA ligase, mitochondrial", "gene_name": "IARS2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRWGLRPRGPGAAALATARSLWGTPRLPCSPGWQGATKRLLVRSVSGASNHQPNSNSGRYRDTVLLPQTSFPMKLLGRQQPDTELEIQQKCGFSELYSWQRERKVKTEFCLHDGPPYANGDPHVGHALNKILKDIANRFHMMNGSKIHFVPGWDCHGLPIEIKVLSELGREAQNLSAMEIRKKARSFAKAAIEKQKSAFIRWGIMADWNNCYYTFDGKYEAKQLRTFYQMYDKGLVYRSYKPVFWSPSSRTALAEAELEYNPEHVSRSIYVKFPLLKPSPKLASLIDGSSPVSILVWTTQPWTIPANEAVCYMPESKYAVVKCSKSGDLYVLAADKVASVASTLETTFETISTLSGVDLENGTCSHPLIPDKASPLLPANHVTMAKGTGLVHTAPAHGMEDYGVASQHNLPMDCLVDEDGVFTDVAGPELQNKAVLEEGTDVVIKMLQTAKNLLKEEKLVHSYPYDWRTKKPVVIRASKQWFINITDIKTAAKELLKKVKFIPGSALNGMVEMMDRRPYWCISRQRVWGVPIPVFHHKTKDEYLINSQTTEHIVKLVEQHGSDIWWTLPPEQLLPKEVLSEVGGPDALEYVPGQDILDIWFDSGTSWSYVLPGPDQRADLYLEGKDQLGGWFQSSLLTSVAARKRAPYKTVIVHGFTLGEKGEKMSKSLGNVIHPDVVVNGGQDQSKEPPYGADVLRWWVADSNVFTEVAIGPSVLNAARDDISKLRNTLRFLLGNVADFNPETDSIPVNDMYVIDQYMLHLLQDLANKITELYKQYDFGKVVRLLRTFYTRELSNFYFSIIKDRLYCEKENDPKRRSCQTALVEILDVIVRSFAPILPHLAEEVFQHIPYIKEPKSVFRTGWISTSSIWKKPGLEEAVESACAMRDSFLGSIPGKNAAEYKVITVIEPGLLFEIIEMLQSEETSSTSQLNELMMASESTLLAQEPREMTADVIELKGKFLINLEGGDIREESSYKVIVMPTTKEKCPRCWKYTAESSDTLCPRCAEVVSGK", "length": 1012 }, "evidence": [ { "id": "A0A0G2K261", "url": "https://omabrowser.org/oma/group/A0A0G2K261/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VUY4-1", "protein_name": "isoleucine--tRNA ligase", "gene_name": "IleRS-m", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MLRIFYFRVGNRLYSMKAAKKDAKKYTDTINLPKTKFPNRLTAAKREEQERLVLENKIAVSYAYQEQRLAEKGKPTFVLHDGPPYANGQLHMGHAVNKILKDITLRQRVAHGQRVNYIPGWDCHGLPIELKATSTAPGQSAQEIRQKSRAFAWEAIKSQKEEFSSWGILANWQKDNIYMTFQPEFIVNQLEMFYNLYEKGLVYRDLKPVYWSPSSRTALAEAELEYDANHISPSVYVRFALNPSSFDVKDKQIYALVWTTTPWTLPSNQAICYNASLEYVIVRLSDRNQDELYLMASALMADFEANTQLKCEIVQHLSGELLSKLSYNHPIDKEQSNLPFFDASHVQDSKGTGLVHTAPAHGPEDFLVSLTQKIPVKCFVNEEGTYTKEAPDFLRGKSVLDQGNSLVLDRIAEDVVHSSKLEHSYPIDWRTKKPVIIRASEQWFINTEKLKTPAADALEQVEIYPRANAEASKKALLTQLQKRPYWCISRQRAWGVPIPVLYSRESGKVVLNSALIEHLCNLLRKEGSIDFWWVKSVEELVPEHLLRELHHEAKDLVKGTDILDIWFDSGSTWSAVLGKDKIADLYLEGYDQFTGWFQSSLLMSIAARECAPYKALFVHGFTVDEKGYKMSKSLGNVISPKQITKKYGTDALRWWVASHGTQHMSITVSDKLLQQAAENLCKIRGTMRYLKGVIGEKQSGEKLIRTSDKSYLNRYLLSQLVEFESEVEKLYQAYEYNRVVACVQNFIANQVSAVYVHLIKDRLYCGDDHELLAIRQTLTHCYQQLCKSLWPIVPFLVEESWSYYDTTGGAFHEQIVQTNPEWQDTKATEVINAAFDVKRLINQQAGDVNTWHLAVTIKGKERSQLDLLRELHSPLGESVSNSELCEILQVGSVTLLQSHNSDLDIALSKLQISLCPRCRRYGLEDEQKTCQRCSDVMEAKN", "length": 941 }, "evidence": [ { "id": "A0A0G2K261", "url": "https://omabrowser.org/oma/group/A0A0G2K261/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "aminoacyl-tRNA editing activity", "id": "GO:0002161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002161", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K261", "url": "https://www.uniprot.org/uniprot/A0A0G2K261" } ], "pmid": "" }, { "name": "isoleucine-tRNA ligase activity", "id": "GO:0004822", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004822", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K261", "url": "https://www.uniprot.org/uniprot/A0A0G2K261" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K261", "url": "https://www.uniprot.org/uniprot/A0A0G2K261" } ], "pmid": "" }, { "name": "tRNA binding", "id": "GO:0000049", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000049", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K261", "url": "https://www.uniprot.org/uniprot/A0A0G2K261" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "isoleucyl-tRNA aminoacylation", "id": "GO:0006428", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006428", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K261", "url": "https://www.uniprot.org/uniprot/A0A0G2K261" } ], "pmid": "" }, { "name": "mitochondrial translation", "id": "GO:0032543", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032543", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K261", "url": "https://www.uniprot.org/uniprot/A0A0G2K261" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K261", "url": "https://www.uniprot.org/uniprot/A0A0G2K261" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 968, "end_pos": 970, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-RNO-9838081", "name": "LONP1 degrades mitochondrial matrix proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P22791-1", "Q62651-1", "P10719-1", "P10860-1", "O88267-1", "P04636-1", "B2GV15-1", "P17764-1", "P63039-1", "P70584-1", "Q9ER34-1", "P07633-1", "Q66HF1-1", "G3V6R7-1", "O55171-1", "P11884-1", "P14408-1", "P23965-1", "Q66HF8-1", "Q8VHF5-1", "B2GV06-1", "Q63065-1", "O08701-1", "P49432-1", "Q5XI78-1", "Q924S5-1", "O70351-1", "Q1HCL7-1", "Q9WVK7-1", "A0A0G2K261-1", "D3ZBM3-1" ], "evidence": [ { "id": "R-RNO-9838081", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9838081" } ] }, { "id": "R-RNO-9838093", "name": "LONP1 binds mitochondrial matrix proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P22791-1", "Q62651-1", "P10719-1", "P10860-1", "O88267-1", "P04636-1", "B2GV15-1", "P17764-1", "P63039-1", "P70584-1", "Q9ER34-1", "P07633-1", "Q66HF1-1", "G3V6R7-1", "O55171-1", "P11884-1", "P14408-1", "P23965-1", "Q66HF8-1", "Q8VHF5-1", "B2GV06-1", "Q63065-1", "O08701-1", "P49432-1", "Q5XI78-1", "Q924S5-1", "O70351-1", "Q1HCL7-1", "Q9WVK7-1", "A0A0G2K261-1", "D3ZBM3-1" ], "evidence": [ { "id": "R-RNO-9838093", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9838093" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A0G2K261", "gene_name": "Iars2", "activity": [ { "ec_number": "6.1.1.5", "activity": "ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile).", "evidence": [ { "id": "A0A0G2K261", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K261" } ] }, { "ec_number": "6.1.1.5", "activity": "", "evidence": [ { "id": "A0A0G2K261", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K261" } ] } ] }, { "uniprot_ac": "B2GV06", "gene_name": "Oxct1", "activity": [ { "ec_number": "2.8.3.5", "activity": "a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate.", "evidence": [ { "id": "B2GV06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2GV06" } ] }, { "ec_number": "2.8.3.5", "activity": "", "evidence": [ { "id": "B2GV06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2GV06" } ] } ] }, { "uniprot_ac": "B2GV15", "gene_name": "Dbt", "activity": [ { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "B2GV15", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2GV15" } ] } ] }, { "uniprot_ac": "D3ZBM3", "gene_name": "Fech", "activity": [ { "ec_number": "4.98.1.1", "activity": "2 H(+) + heme b = Fe(2+) + protoporphyrin IX.", "evidence": [ { "id": "D3ZBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZBM3" } ] }, { "ec_number": "4.98.1.1", "activity": "", "evidence": [ { "id": "D3ZBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZBM3" } ] } ] }, { "uniprot_ac": "G3V6R7", "gene_name": "Oxsm", "activity": [ { "ec_number": "2.3.1.41", "activity": "a fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + holo-[ACP].", "evidence": [ { "id": "G3V6R7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V6R7" } ] }, { "ec_number": "2.3.1.41", "activity": "", "evidence": [ { "id": "G3V6R7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V6R7" } ] } ] }, { "uniprot_ac": "O08701", "gene_name": "Arg2", "activity": [ { "ec_number": "3.5.3.1", "activity": "H2O + L-arginine = L-ornithine + urea.", "evidence": [ { "id": "O08701", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08701" } ] }, { "ec_number": "3.5.3.1", "activity": "", "evidence": [ { "id": "O08701", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08701" } ] } ] }, { "uniprot_ac": "O55171", "gene_name": "Acot2", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "O55171", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55171" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "O55171", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55171" } ] } ] }, { "uniprot_ac": "O70351", "gene_name": "Hsd17b10", "activity": [ { "ec_number": "1.1.1.35", "activity": "a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH.", "evidence": [ { "id": "O70351", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70351" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "O70351", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70351" } ] }, { "ec_number": "1.1.1.239", "activity": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "O70351", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70351" } ] }, { "ec_number": "1.1.1.178", "activity": "(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD(+) = 2-methyl-3-oxobutanoyl-CoA + H(+) + NADH.", "evidence": [ { "id": "O70351", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70351" } ] }, { "ec_number": "1.1.1.53", "activity": "5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH.", "evidence": [ { "id": "O70351", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70351" } ] }, { "ec_number": "1.1.1.159", "activity": "cholate + NAD(+) = 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADH.", "evidence": [ { "id": "O70351", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70351" } ] }, { "ec_number": "1.1.1.35", "activity": "", "evidence": [ { "id": "O70351", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70351" } ] } ] }, { "uniprot_ac": "O88267", "gene_name": "Acot1", "activity": [ { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "O88267", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88267" } ] }, { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "O88267", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88267" } ] } ] }, { "uniprot_ac": "P04636", "gene_name": "Mdh2", "activity": [ { "ec_number": "1.1.1.37", "activity": "(S)-malate + NAD(+) = H(+) + NADH + oxaloacetate.", "evidence": [ { "id": "P04636", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04636" } ] }, { "ec_number": "1.1.1.37", "activity": "", "evidence": [ { "id": "P04636", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04636" } ] } ] }, { "uniprot_ac": "P07633", "gene_name": "Pccb", "activity": [ { "ec_number": "6.4.1.3", "activity": "ATP + hydrogencarbonate + propanoyl-CoA = (S)-methylmalonyl-CoA + ADP + H(+) + phosphate.", "evidence": [ { "id": "P07633", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07633" } ] }, { "ec_number": "6.4.1.3", "activity": "", "evidence": [ { "id": "P07633", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07633" } ] } ] }, { "uniprot_ac": "P10719", "gene_name": "Atp5f1b", "activity": [ { "ec_number": "7.1.2.2", "activity": "ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate.", "evidence": [ { "id": "P10719", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10719" } ] }, { "ec_number": "7.1.2.2", "activity": "", "evidence": [ { "id": "P10719", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10719" } ] } ] }, { "uniprot_ac": "P10860", "gene_name": "Glud1", "activity": [ { "ec_number": "1.4.1.3", "activity": "H2O + L-glutamate + NAD(+) = 2-oxoglutarate + H(+) + NADH + NH4(+).", "evidence": [ { "id": "P10860", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10860" } ] }, { "ec_number": "1.4.1.3", "activity": "", "evidence": [ { "id": "P10860", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10860" } ] } ] }, { "uniprot_ac": "P11884", "gene_name": "Aldh2", "activity": [ { "ec_number": "1.2.1.3", "activity": "an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH.", "evidence": [ { "id": "P11884", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11884" } ] }, { "ec_number": "1.2.1.3", "activity": "", "evidence": [ { "id": "P11884", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11884" } ] } ] }, { "uniprot_ac": "P14408", "gene_name": "Fh", "activity": [ { "ec_number": "4.2.1.2", "activity": "(S)-malate = fumarate + H2O.", 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