{
    "uniprot_canonical_ac": "A0A0G2K059-1",
    "uniprot_ac": "A0A0G2K059",
    "uniprot_id": "A0A0G2K059_RAT",
    "mass": {
        "chemical_mass": 37602.0,
        "monoisotopic_mass": 37602.0
    },
    "refseq": {},
    "gene_names": [
        {
            "name": "Mcu",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A0A0G2K059",
            "id": "A0A0G2K059"
        }
    ],
    "protein_names": [
        {
            "name": "Calcium uniporter protein",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprotkb/A0A0G2K059/entry#names_and_taxonomy",
            "id": "A0A0G2K059"
        }
    ],
    "function": [
        {
            "annotation": "Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes a pore-forming and calcium-conducting subunit. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A0G2K059",
                    "url": "https://www.uniprot.org/uniprot/A0A0G2K059#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "RU367035",
                    "url": "https://www.uniprot.org/uniprot/RU367035#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "A0A8I6A2V9",
                    "url": "https://www.uniprot.org/uniprot/A0A8I6A2V9#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "M0RDI5",
                    "url": "https://www.uniprot.org/uniprot/M0RDI5#function"
                }
            ]
        }
    ],
    "disease": [
        {
            "disease_id": "DOID:0050700",
            "recommended_name": {
                "id": "DOID:0050700",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0050700",
                "name": "cardiomyopathy",
                "description": "A heart disease and a myopathy that is characterized by deterioration of the function of the heart muscle."
            },
            "synonyms": [
                {
                    "id": "DOID:0050700",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0050700",
                    "name": "Cardiomyopathies",
                    "description": ""
                }
            ],
            "evidence": [
                {
                    "id": "0050700",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050700"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A0G2K059",
                    "url": "https://www.uniprot.org/uniprot/A0A0G2K059"
                }
            ],
            "common_name": "Rat",
            "glygen_name": "Rat",
            "reference_species": "Rattus norvegicus [10116]"
        }
    ],
    "gene": [
        {
            "name": "Mcu",
            "url": "https://www.uniprot.org/uniprot/A0A0G2K059",
            "locus": {
                "chromosome": "20",
                "start_pos": 27417526,
                "end_pos": 27580110,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSRNOG00000045920",
                        "url": "https://www.ensembl.org/id/ENSRNOG00000045920"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "A0A0G2K059",
            "url": "https://alphafold.ebi.ac.uk/entry/A0A0G2K059",
            "database": "AlphaFoldDB",
            "categories": []
        },
        {
            "id": "ENSRNOG00000045920",
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000045920",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "IPR006769",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR006769",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR039055",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR039055",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "DDIYVEY",
            "url": "https://omabrowser.org/oma/group/DDIYVEY/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "A0A0G2K059",
            "url": "https://www.orthodb.org/?gene=A0A0G2K059",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "M0RDI5",
            "url": "https://www.orthodb.org/?gene=M0RDI5",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR13462",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13462",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR13462:SF16",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13462:SF16",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF04678",
            "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04678",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-8949215",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8949215",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-8949664",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8949664",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "1589771",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1589771",
            "database": "RGD",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "A0A0G2K059",
            "url": "https://www.uniprot.org/uniprot/A0A0G2K059",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A0G2K059-1",
            "url": "https://www.uniprot.org/uniprot/A0A0G2K059-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8I6A2V9",
            "url": "https://www.uniprot.org/uniprot/A0A8I6A2V9",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8I6A2V9-1",
            "url": "https://www.uniprot.org/uniprot/A0A8I6A2V9-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "M0RDI5",
            "url": "https://www.uniprot.org/uniprot/M0RDI5",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "M0RDI5-1",
            "url": "https://www.uniprot.org/uniprot/M0RDI5-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MAAAAGRSLLLLLCSRGGGGGAGGCGALTAGCFPGLGVSRQRPHQQHRTAHQRPASWQSVGAAYCSTVVPSDDVTVVYQNGLPVISVRLPSRRERCQFTLKPISDSVGVFLRQLQEEDRGIDRVAIYSPDGVRVAASTGIDLLLLDDFKLVINDLTYHVRPPKRDLLSHENAETLNDVKTLVQQLYTTLCIEQHQLNKERELVERLEDLRQQLAPLEKVRIEISRKAEKRTTLVLWGGLAYMATQFGILARLTWWEYSWDIMEPVTYFITYGSAMAMYAYFVMTRQEYVYPEARDRQYLLFFHKGAKKSRFDLEKYNQLKDAIAQKWILRD",
        "length": 331,
        "header": "tr|A0A0G2K059-1|A0A0G2K059_RAT Isoform 1 of Calcium uniporter protein  OS=Rattus norvegicus OX=10116 GN=Mcu PE=1 SV=2 CANONICAL=A0A0G2K059-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A0G2K059-1",
            "url": "https://www.uniprot.org/uniprotkb/A0A0G2K059/entry#A0A0G2K059-1",
            "sequence": {
                "sequence": "MAAAAGRSLLLLLCSRGGGGGAGGCGALTAGCFPGLGVSRQRPHQQHRTAHQRPASWQSVGAAYCSTVVPSDDVTVVYQNGLPVISVRLPSRRERCQFTLKPISDSVGVFLRQLQEEDRGIDRVAIYSPDGVRVAASTGIDLLLLDDFKLVINDLTYHVRPPKRDLLSHENAETLNDVKTLVQQLYTTLCIEQHQLNKERELVERLEDLRQQLAPLEKVRIEISRKAEKRTTLVLWGGLAYMATQFGILARLTWWEYSWDIMEPVTYFITYGSAMAMYAYFVMTRQEYVYPEARDRQYLLFFHKGAKKSRFDLEKYNQLKDAIAQKWILRD",
                "length": 331,
                "header": "tr|A0A0G2K059-1|A0A0G2K059_RAT Isoform 1 of Calcium uniporter protein  OS=Rattus norvegicus OX=10116 GN=Mcu PE=1 SV=2 CANONICAL=A0A0G2K059-1"
            },
            "locus": {
                "chromosome": "20",
                "start_pos": 27580100,
                "end_pos": 27419340,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000090771.2",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000090771.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000071314.2",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000071314.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A0A8I6A2V9-1",
            "url": "https://www.uniprot.org/uniprotkb/A0A0G2K059/entry#A0A8I6A2V9-1",
            "sequence": {
                "sequence": "MQGKLERSQAHQRPASWQSVGAAYCSTVVPSDDVTVVYQNGLPVISVRLPSRRERCQFTLKPISDSVGVFLRQLQEEDRGIDRVAIYSPDGVRVAASTGIDLLLLDDFKLVINDLTYHVRPPKRDLLSHENAETLNDVKTLVQQLYTTLCIEQHQLNKERELVERLEDLRQQLAPLEKVRIEISRKAEKRTTLVLWGGLAYMATQFGILARLTWWEYSWDIMEPVTYFITYGSAMAMYAYFVMTRQEYVYPEARDRQYLLFFHKGAKKSRFDLEKYNQLKDAIAQAEMDLKRLRDPLQVHLPLRQIGEKE",
                "length": 310,
                "header": "tr|A0A8I6A2V9-1|A0A0G2K059_RAT Computationally mapped isoform of Calcium uniporter protein  OS=Rattus norvegicus OX=10116 GN=Mcu PE=1 SV=1 CANONICAL=A0A0G2K059-1"
            },
            "locus": {
                "chromosome": "20",
                "start_pos": 27564247,
                "end_pos": 27419287,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000102262.1",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000102262.1"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000086023.1",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000086023.1"
                    }
                ]
            }
        },
        {
            "isoform_ac": "M0RDI5-1",
            "url": "https://www.uniprot.org/uniprotkb/A0A0G2K059/entry#M0RDI5-1",
            "sequence": {
                "sequence": "MVLMLFSVRLPMYMGGCVCLQCAHQRPASWQSVGAAYCSTVVPSDDVTVVYQNGLPVISVRLPSRRERCQFTLKPISDSVGVFLRQLQEEDRGIDRVAIYSPDGVRVAASTGIDLLLLDDFKLVINDLTYHVRPPKRDLLSHENAETLNDVKTLVQQLYTTLCIEQHQLNKERELVERLEDLRQQLAPLEKVRIEISRKAEKRTTLVLWGGLAYMATQFGILARLTWWEYSWDIMEPVTYFITYGSAMAMYAYFVMTRQEYVYPEARDRQYLLFFHKGAKKSRFDLEKYNQLKDAIAQAEMDLKRLRDPLQVHLPLRQIGEKE",
                "length": 323,
                "header": "tr|M0RDI5-1|A0A0G2K059_RAT Computationally mapped isoform of Calcium uniporter protein  OS=Rattus norvegicus OX=10116 GN=Mcu PE=1 SV=2 CANONICAL=A0A0G2K059-1"
            },
            "locus": {
                "chromosome": "20",
                "start_pos": 27460500,
                "end_pos": 27419287,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000071477.2",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000071477.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000067686.2",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000067686.2"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [],
    "pathway": [
        {
            "id": "R-RNO-8949215",
            "name": "Mitochondrial calcium ion transport",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8949215",
            "resource": "Reactome",
            "description": "Mitochondrial calcium ion transport"
        },
        {
            "id": "R-RNO-8949664",
            "name": "Processing of SMDT1",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8949664",
            "resource": "Reactome",
            "description": "Processing of SMDT1"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "A0AAA9SGL4-1",
            "protein_name": "Calcium uniporter protein",
            "gene_name": "MCU",
            "tax_id": 9913,
            "organism": "Bos taurus",
            "sequence": {
                "sequence": "MAAAAGRSLLLLLSSRGGGGGGAGGCGALTAGCFPALGVSRHRQQQHHRTVHQRLSSWPNLGVVYCSTVVPSDDVTVVYQNGLPVISVRLPSRRERCQFTLKPISDSVGVFLRQLQEEDRGIDRVAIYSPDGVRVAASTGIDLLLLDDFKLVINDLTYHVRPPKRDLLSHENAATLNDVKTLVQQLYTTLCIEQHQLNKERELIERLEDLKEQLAPLEKVRIEISRKAEKRTTLVLWGGLAYMATQFGILARLTWWEYSWDIMEPVTYFITYGSAMAMYAYFVMTRQEYVYPEARDRQYLLFFHKGAKKSRFDLEKYNQLKDAIAQKWT",
                "length": 329
            },
            "evidence": [
                {
                    "id": "A0A0G2K059",
                    "url": "https://omabrowser.org/oma/group/A0A0G2K059/",
                    "database": "OMA"
                }
            ],
            "glygen_name": "Bovine",
            "common_name": "Bovine"
        },
        {
            "uniprot_canonical_ac": "Q3UMR5-1",
            "protein_name": "Calcium uniporter protein, mitochondrial",
            "gene_name": "Mcu",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MAAAAGRSLLLLLCSRGGGGGAGGCGALTAGCFPGLGVSRHRPHQQHRTAHQRPASWQSVGAAYCSTVVPSDDVTVVYQNGLPVISVRLPSRRERCQFTLKPISDSVGVFLRQLQEEDRGIDRVAIYSPDGVRVAASTGIDLLLLDDFKLVINDLTYHVRPPKRDLLSHEDAATLNDVKTLVQQLYTTLCIEQHQLNKERELVERLEDLKQQLAPLEKVRIEISRKAEKRTTLVLWGGLAYMATQFGILARLTWWEYSWDIMEPVTYFITYGSAMAMYAYFVMTRQEYVYPEARDRQYLLFFHKGAKKSRFDLEKYNQLKDAIAQAEMDLKRLRDPLQVHLPLRQIGEKE",
                "length": 350
            },
            "evidence": [
                {
                    "id": "A0A0G2K059",
                    "url": "https://omabrowser.org/oma/group/A0A0G2K059/",
                    "database": "OMA"
                }
            ],
            "glygen_name": "Mouse",
            "common_name": "Mouse"
        },
        {
            "uniprot_canonical_ac": "Q8NE86-1",
            "protein_name": "Calcium uniporter protein, mitochondrial",
            "gene_name": "MCU",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MAAAAGRSLLLLLSSRGGGGGGAGGCGALTAGCFPGLGVSRHRQQQHHRTVHQRIASWQNLGAVYCSTVVPSDDVTVVYQNGLPVISVRLPSRRERCQFTLKPISDSVGVFLRQLQEEDRGIDRVAIYSPDGVRVAASTGIDLLLLDDFKLVINDLTYHVRPPKRDLLSHENAATLNDVKTLVQQLYTTLCIEQHQLNKERELIERLEDLKEQLAPLEKVRIEISRKAEKRTTLVLWGGLAYMATQFGILARLTWWEYSWDIMEPVTYFITYGSAMAMYAYFVMTRQEYVYPEARDRQYLLFFHKGAKKSRFDLEKYNQLKDAIAQAEMDLKRLRDPLQVHLPLRQIGEKD",
                "length": 351
            },
            "evidence": [
                {
                    "id": "A0A0G2K059",
                    "url": "https://omabrowser.org/oma/group/A0A0G2K059/",
                    "database": "OMA"
                }
            ],
            "glygen_name": "Human",
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Molecular Function",
                "total": 2,
                "go_terms": [
                    {
                        "name": "calcium channel activity",
                        "id": "GO:0005262",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005262",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K059",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K059"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "uniporter activity",
                        "id": "GO:0015292",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015292",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K059",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K059"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 3,
                "go_terms": [
                    {
                        "name": "mitochondrial inner membrane",
                        "id": "GO:0005743",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K059",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K059"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "calcium channel complex",
                        "id": "GO:0034704",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034704",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K059",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K059"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "uniplex complex",
                        "id": "GO:1990246",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990246",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K059",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K059"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 10,
                "go_terms": [
                    {
                        "name": "calcium-mediated signaling",
                        "id": "GO:0019722",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019722",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K059",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K059"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of insulin secretion",
                        "id": "GO:0032024",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032024",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K059",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K059"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "protein complex oligomerization",
                        "id": "GO:0051259",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051259",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K059",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K059"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "glucose homeostasis",
                        "id": "GO:0042593",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042593",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K059",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K059"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "mitochondrial calcium ion transmembrane transport",
                        "id": "GO:0006851",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006851",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K059",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K059"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "calcium import into the mitochondrion",
                        "id": "GO:0036444",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036444",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K059",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K059"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "mitochondrial calcium ion homeostasis",
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