{ "uniprot_canonical_ac": "A0A0G2JTY4-1", "uniprot_ac": "A0A0G2JTY4", "uniprot_id": "NFAC3_RAT", "mass": { "chemical_mass": 115656.0, "monoisotopic_mass": 115656.0 }, "refseq": {}, "gene_names": [ { "name": "Nfatc3", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4", "id": "A0A0G2JTY4" }, { "name": "Nfat4", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4", "id": "A0A0G2JTY4" } ], "protein_names": [ { "name": "Nuclear factor of activated T-cells, cytoplasmic 3", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JTY4/entry#names_and_taxonomy", "id": "A0A0G2JTY4" }, { "name": "NFATc3", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JTY4/entry#names_and_taxonomy", "id": "A0A0G2JTY4" }, { "name": "NFATx", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JTY4/entry#names_and_taxonomy", "id": "A0A0G2JTY4" }, { "name": "T-cell transcription factor NFAT4", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JTY4/entry#names_and_taxonomy", "id": "A0A0G2JTY4" } ], "function": [ { "annotation": "Acts as a regulator of transcriptional activation. Binds to the TNFSF11/RANKL promoter region and promotes TNFSF11 transcription (By similarity). Binding to the TNFSF11 promoter region is increased by high levels of Ca(2+) which induce NFATC3 expression and may lead to regulation of TNFSF11 expression in osteoblasts (By similarity). Plays a role in promoting mesenteric arterial wall remodeling in response to the intermittent hypoxia-induced increase in EDN1 and ROCK signaling (By similarity). As a result NFATC3 colocalizes with F-actin filaments, translocates to the nucleus and promotes transcription of the smooth muscle hypertrophy and differentiation marker ACTA2 (By similarity). Promotes lipopolysaccharide-induced apoptosis and hypertrophy in cardiomyocytes (PubMed:30980393). Following JAK/STAT signaling activation and as part of a complex with NFATC4 and STAT3, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (PubMed:19538478). In conjunction with NFATC4, involved in embryonic heart development via maintenance of cardiomyocyte survival, proliferation and differentiation (By similarity). Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 (By similarity). Required for thymocyte maturation during DN3 to DN4 transition and during positive selection (By similarity). Positively regulates macrophage-derived polymicrobial clearance, via binding to the promoter region and promoting transcription of NOS2 resulting in subsequent generation of nitric oxide (By similarity). Involved in Ca(2+)-mediated transcriptional responses upon Ca(2+) influx via ORAI1 CRAC channels.", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4#function" }, { "database": "UniProtKB", "id": "P97305", "url": "https://www.uniprot.org/uniprot/P97305#function" }, { "database": "PubMed", "id": "30980393", "url": "https://glygen.org/publication/PubMed/30980393" }, { "database": "UniProtKB", "id": "Q12968", "url": "https://www.uniprot.org/uniprot/Q12968#function" }, { "database": "PubMed", "id": "19538478", "url": "https://glygen.org/publication/PubMed/19538478" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "gene": [ { "name": "Nfatc3", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4", "locus": { "chromosome": "19", "start_pos": 34035150, "end_pos": 33960852, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000054264", "url": "https://www.ensembl.org/id/ENSRNOG00000054264" } ] } } ], "crossref": [ { "id": "A0A0G2JTY4", "url": "https://alphafold.ebi.ac.uk/entry/A0A0G2JTY4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSRNOG00000054264", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000054264", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01178", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01178", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd07881", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07881", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "361400", "url": "https://www.ncbi.nlm.nih.gov/gene/361400", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008366", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008366", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008967", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008967", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011539", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011539", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014756", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014756", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032397", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032397", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037059", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037059", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:361400", "url": "https://www.genome.jp/dbget-bin/www_bget?rno:361400", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QGHKSYE", "url": "https://omabrowser.org/oma/group/QGHKSYE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A0G2JTY4", "url": "https://www.orthodb.org/?gene=A0A0G2JTY4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "D3ZU59", "url": "https://www.orthodb.org/?gene=D3ZU59", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12533", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12533", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12533:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12533:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00554", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00554", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF16179", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16179", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-2025928", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2025928", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-2871809", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2871809", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-5607763", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5607763", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "XP_006255575", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006255575", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "1308692", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1308692", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2JTY4-1", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6AB55", "url": "https://www.uniprot.org/uniprot/A0A8I6AB55", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6AB55-1", "url": "https://www.uniprot.org/uniprot/A0A8I6AB55-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3ZU59", "url": "https://www.uniprot.org/uniprot/D3ZU59", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3ZU59-1", "url": "https://www.uniprot.org/uniprot/D3ZU59-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTTANCGAHDELDFKLVFGEDGAPTPVSQVSRPADLEPDDCASIYIFNVDPPPSTLNSSLGLPHHGLLQSHSSVLSPSFQLQGFKNYEGTDDISESKYSSLSGPKPFECPSIQITSISPNCHQETDAHEDDLHVNDPEREYLERPSRDHLYLPLEPSYRESSLSPSPASSVSSRSWFSDASSCESLSHIYDDVDSELNEAAARFTLGSPLTSPGGSPGGCPGEESWHQQYGPGHSLSPRQSPCHSPRSSITDENWLSPRPASGPSSRPTSPCGKRRHSSAEVCYAGSLSPHHSPVPSPGHSPRGSVTEDTWLTAPVHTGSGLSPAPFPFQYCVETDIPLKTRKTSDDQAAILPGKLEVCSDDQGSLSPSRETSVDDGLGSQYPLKKDSSGDQFLSVPSPFTWSKPKPGHTPIFRTSSLPPLDWPLPTHFGQCELKIEVQPKTHHRAHYETEGSRGAVKASTGGHPVVKLLGYSEKPINLQMFIGTADDRYLRPHAFYQVHRITGKTVATASQEIIIASTKVLEIPLLPENNMSASIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHIPQPSGKVLSLQIASIPVECSQRSAQELPHIEKYSINSCSVNGGHEMIVTGSNFLPESKIIFLEKGQDGRPHWEAEGKIIREKCQGGHIVLEVPPYHNPAVTSAVQVHFYLCNGKRKKSQSQRFTYTPVLMKQEQREDTDLSSVPSLPVPHSAQTQRPSSDTGHPHDSALSAPRSLICPVQPAYASMITSTHLPQLQCRDEGAGKEQHIIPSSVMHQPFQVTPTSPMGSSYQSIQTNMYNGPTCLPMNPASSQEFDPVLFQQDAALSNLVNLGCQPLSPIPFHSSNSDATGHLLAHSPHSVQTPPHLQSMGYHCSSAGQRSLSSPVAAQVTGQPSSHLQPITYCPSHPGSATAASPAASHALSSSPISGPPSPQLQSMPYQSPSSGTASSPSPVTRMHSGQHSTQAQSTGQGGLSVPSSLVCHSLCDPASFPPGGAAVSIKPEPEDQEPNFATIGLQDITLDDVNEIIGRDMSQITVSQGPEVIRDAPLPGPESPDVMSSNSAQ", "length": 1076, "header": "sp|A0A0G2JTY4-1|NFAC3_RAT Isoform 1 of Nuclear factor of activated T-cells, cytoplasmic 3 OS=Rattus norvegicus OX=10116 GN=Nfatc3 PE=1 SV=1 CANONICAL=A0A0G2JTY4-1" }, "isoforms": [ { "isoform_ac": "A0A0G2JTY4-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JTY4/entry#A0A0G2JTY4-1", "sequence": { "sequence": "MTTANCGAHDELDFKLVFGEDGAPTPVSQVSRPADLEPDDCASIYIFNVDPPPSTLNSSLGLPHHGLLQSHSSVLSPSFQLQGFKNYEGTDDISESKYSSLSGPKPFECPSIQITSISPNCHQETDAHEDDLHVNDPEREYLERPSRDHLYLPLEPSYRESSLSPSPASSVSSRSWFSDASSCESLSHIYDDVDSELNEAAARFTLGSPLTSPGGSPGGCPGEESWHQQYGPGHSLSPRQSPCHSPRSSITDENWLSPRPASGPSSRPTSPCGKRRHSSAEVCYAGSLSPHHSPVPSPGHSPRGSVTEDTWLTAPVHTGSGLSPAPFPFQYCVETDIPLKTRKTSDDQAAILPGKLEVCSDDQGSLSPSRETSVDDGLGSQYPLKKDSSGDQFLSVPSPFTWSKPKPGHTPIFRTSSLPPLDWPLPTHFGQCELKIEVQPKTHHRAHYETEGSRGAVKASTGGHPVVKLLGYSEKPINLQMFIGTADDRYLRPHAFYQVHRITGKTVATASQEIIIASTKVLEIPLLPENNMSASIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHIPQPSGKVLSLQIASIPVECSQRSAQELPHIEKYSINSCSVNGGHEMIVTGSNFLPESKIIFLEKGQDGRPHWEAEGKIIREKCQGGHIVLEVPPYHNPAVTSAVQVHFYLCNGKRKKSQSQRFTYTPVLMKQEQREDTDLSSVPSLPVPHSAQTQRPSSDTGHPHDSALSAPRSLICPVQPAYASMITSTHLPQLQCRDEGAGKEQHIIPSSVMHQPFQVTPTSPMGSSYQSIQTNMYNGPTCLPMNPASSQEFDPVLFQQDAALSNLVNLGCQPLSPIPFHSSNSDATGHLLAHSPHSVQTPPHLQSMGYHCSSAGQRSLSSPVAAQVTGQPSSHLQPITYCPSHPGSATAASPAASHALSSSPISGPPSPQLQSMPYQSPSSGTASSPSPVTRMHSGQHSTQAQSTGQGGLSVPSSLVCHSLCDPASFPPGGAAVSIKPEPEDQEPNFATIGLQDITLDDVNEIIGRDMSQITVSQGPEVIRDAPLPGPESPDVMSSNSAQ", "length": 1076, "header": "sp|A0A0G2JTY4-1|NFAC3_RAT Isoform 1 of Nuclear factor of activated T-cells, cytoplasmic 3 OS=Rattus norvegicus OX=10116 GN=Nfatc3 PE=1 SV=1 CANONICAL=A0A0G2JTY4-1" }, "locus": { "chromosome": "19", "start_pos": 34032608, "end_pos": 33960933, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000087491.2", "url": "https://www.ensembl.org/id/ENSRNOT00000087491.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000068890.1", "url": "https://www.ensembl.org/id/ENSRNOP00000068890.1" } ] } }, { "isoform_ac": "A0A8I6AB55-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JTY4/entry#A0A8I6AB55-1", "sequence": { "sequence": "MTTANCGAHDELDFKLVFGEDGAPTPVSQVSRPADLEPDDCASIYIFNVDPPPSTLNSSLGLPHHGLLQSHSSVLSPSFQLQGFKNYEGTDDISESKYSSLSGPKPFECPSIQITSISPNCHQETDAHEDDLHVNDPEREYLERPSRDHLYLPLEPSYRESSLSPSPASSVSSRSWFSDASSCESLSHIYDDVDSELNEAAARFTLGSPLTSPGGSPGGCPGEESWHQQYGPGHSLSPRQSPCHSPRSSITDENWLSPRPASGPSSRPTSPCGKRRHSSAEVCYAGSLSPHHSPVPSPGHSPRGSVTEDTWLTAPVHTGSGLSPAPFPFQYCVETDIPLKTRKTSDDQAAILPGKLEVCSDDQGSLSPSRETSVDDGLGSQYPLKKDSSGDQFLSVPSPFTWSKPKPGHTPIFRTSSLPPLDWPLPTHFGQCELKIEVQPKTHHRAHYETEGSRGAVKASTGGHPVVKLLGYSEKPINLQMFIGTADDRYLRPHAFYQVHRITGKTVATASQEIIIASTKVLEIPLLPENNMSASIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHIPQPSGKVLSLQIASIPVECSQRSAQELPHIEKYSINSCSVNGGHEMIVTGSNFLPESKIIFLEKGQDGRPHWEAEGKIIREKCQGGHIVLEVPPYHNPAVTSAVQVHFYLCNGKRKKSQSQRFTYTPVLMKQEQREDTDLSSVPSLPVPHSAQTQRPSSDTGHPHDSALSAPRSLICPVQPAYASMITSTHLPQLQCRDEGAGKEQHIIPSSVMHQPFQVTPTSPMGSSYQSIQTNMYNGPTCLPMNPASSQEFDPVLFQQDAALSNLVNLGCQPLSPIPFHSSNSDATGHLLAHSPHSVQTPPHLQSMGYHCSSAGQRSLSSPVAAQVTGQPSSHLQPITYCPSHPGSATAASPAASHALSSSPISGPPSPQLQSMPYQSPSSGTASSPSPVTRMHSGQHSTQAQSTGQGGLSVPSSLVCHSLCDPASFPPGGAAVSIKPEPEDQEPNFATIGLQDITLDDGGTVGNQKGELSQRNSK", "length": 1052, "header": "tr|A0A8I6AB55-1|NFAC3_RAT Computationally mapped isoform of Nuclear factor of activated T-cells, cytoplasmic 3 OS=Rattus norvegicus OX=10116 GN=Nfatc3 PE=1 SV=1 CANONICAL=A0A0G2JTY4-1" }, "locus": { "chromosome": "19", "start_pos": 34031365, "end_pos": 33960933, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000105048.1", "url": "https://www.ensembl.org/id/ENSRNOT00000105048.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000090103.1", "url": "https://www.ensembl.org/id/ENSRNOP00000090103.1" } ] } }, { "isoform_ac": "D3ZU59-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JTY4/entry#D3ZU59-1", "sequence": { "sequence": "MTTANCGAHDELDFKLVFGEDGAPTPVSQVSRPADLEPDDCASIYIFNVDPPPSTLNSSLGLPHHGLLQSHSSVLSPSFQLQGFKNYEGTDDISESKYSSLSGPKPFECPSIQITSISPNCHQETDAHEDDLHVNDPEREYLERPSRDHLYLPLEPSYRESSLSPSPASSVSSRSWFSDASSCESLSHIYDDVDSELNEAAARFTLGSPLTSPGGSPGGCPGEESWHQQYGPGHSLSPRQSPCHSPRSSITDENWLSPRPASGPSSRPTSPCGKRRHSSAEVCYAGSLSPHHSPVPSPGHSPRGSVTEDTWLTAPVHTGSGLSPAPFPFQYCVETDIPLKTRKTSDDQAAILPGKLEVCSDDQGSLSPSRETSVDDGLGSQYPLKKDSSGDQFLSVPSPFTWSKPKPGHTPIFRTSSLPPLDWPLPTHFGQCELKIEVQPKTHHRAHYETEGSRGAVKASTGGHPVVKLLGYSEKPINLQMFIGTADDRYLRPHAFYQVHRITGKTVATASQEIIIASTKVLEIPLLPENNMSASIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHIPQPSGKVLSLQIASIPVECSQRSAQELPHIEKYSINSCSVNGGHEMIVTGSNFLPESKIIFLEKGQDGRPHWEAEGKIIREKCQGGHIVLEVPPYHNPAVTSAVQVHFYLCNGKRKKSQSQRFTYTPVLMKQEQREDTDLSSVPSLPVPHSAQTQRPSSDTGHPHDSALSAPRSLICPVQPAYASMITSTHLPQLQCRDEGAGKEQHIIPSSVMHQPFQVTPTSPMGSSYQSIQTNMYNGPTCLPMNPASSQEFDPVLFQQDAALSNLVNLGCQPLSPIPFHSSNSDATGHLLAHSPHSVQTPPHLQSMGYHCSSAGQRSLSSPVAAQVTGQPSSHLQPITYCPSHPGSATAASPAASHALSSSPISGPPSPQLQSMPYQSPSSGTASSPSPVTRMHSGQHSTQAQSTGQGGLSVPSSLVCHSLCDPASFPPGGAAVSIKPEPEDQEPNFATIGLQDITLDDDQFMSDLEHQPSGSTEKWPNHSEFSCPVPFWRI", "length": 1068, "header": "tr|D3ZU59-1|D3ZU59_RAT Computationally mapped isoform of Nuclear factor of activated T-cells 3 OS=Rattus norvegicus OX=10116 GN=Nfatc3 PE=1 SV=1 CANONICAL=A0A0G2JTY4-1" }, "locus": { "chromosome": "19", "start_pos": 34021886, "end_pos": 33960933, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000089783.2", "url": "https://www.ensembl.org/id/ENSRNOT00000089783.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000069756.1", "url": "https://www.ensembl.org/id/ENSRNOP00000069756.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool": "isoglyp", "mining_tool": "", "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "start_pos": 25, "start_aa": "T", "end_pos": 25, "end_aa": "T", "residue": "Thr", "site_lbl": "Thr25", "evidence": [ { "id": "GLY_001157", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001157" } ], "filter_code": "00000000000000001000.00000000001000.1.01000" } ], "phosphorylation": [ { "start_pos": 1066, "end_pos": 1066, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "site_lbl": "Ser1066" }, { "start_pos": 262, "end_pos": 262, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "D3ZU59", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/D3ZU59" } ], "site_lbl": "Ser262" }, { "start_pos": 265, "end_pos": 265, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "D3ZU59", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/D3ZU59" } ], "site_lbl": "Ser265" }, { "start_pos": 266, "end_pos": 266, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "D3ZU59", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/D3ZU59" } ], "site_lbl": "Ser266" }, { "start_pos": 269, "end_pos": 269, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "D3ZU59", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/D3ZU59" } ], "site_lbl": "Thr269" }, { "start_pos": 270, "end_pos": 270, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "D3ZU59", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/D3ZU59" } ], "site_lbl": "Ser270" }, { "start_pos": 345, "end_pos": 345, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "site_lbl": "Ser345" }, { "start_pos": 373, "end_pos": 373, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "site_lbl": "Ser373" }, { "start_pos": 410, "end_pos": 410, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "D3ZU59", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/D3ZU59" } ], "site_lbl": "Thr410" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Cross-talk between calcineurin/NFAT and Jak/STAT signalling induces cardioprotective alphaB-crystallin gene expression in response to hypertrophic stimuli.", "journal": "Journal of cellular and molecular medicine", "date": "2010-06", "authors": "Manukyan Irena, Galatioto Josephine, Mascareno Eduardo, Bhaduri Sikha, Siddiqui M A Q", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "reference": [ { "type": "PubMed", "id": "19538478", "url": "https://glygen.org/publication/PubMed/19538478" } ] }, { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "journal": "Nat. Commun.", "date": "2012", "authors": "Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "reference": [ { "type": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" } ] }, { "title": "CHIP attenuates lipopolysaccharide-induced cardiac hypertrophy and apoptosis by promoting NFATc3 proteasomal degradation.", "journal": "Journal of cellular physiology", "date": "2019", "authors": "Chao CN, Lai CH, Badrealam KF, Lo JF, Shen CY, Chen CH, Chen RJ, Viswanadha VP, Kuo WW, Huang CY", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "reference": [ { "type": "PubMed", "id": "30980393", "url": "https://glygen.org/publication/PubMed/30980393" } ] } ], "pathway": [ { "id": "rno:361400", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?rno:361400", "resource": "KEGG Pathway" }, { "id": "R-RNO-2025928", "name": "Calcineurin activates NFAT", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2025928", "resource": "Reactome", "description": "Calcineurin activates NFAT" }, { "id": "R-RNO-2871809", "name": "FCERI mediated Ca+2 mobilization", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2871809", "resource": "Reactome", "description": "FCERI mediated Ca+2 mobilization" }, { "id": "R-RNO-5607763", "name": "CLEC7A (Dectin-1) induces NFAT activation", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5607763", "resource": "Reactome", "description": "CLEC7A (Dectin-1) induces NFAT activation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5P8S9-1", "protein_name": "Nuclear factor of activated T cells 3", "gene_name": "NFATC3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": 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"MTTANCGAHDELDFKLVFGEDGAPAPPPPGSRPADLEPDDCASIYIFNVDPPPSTLTTPLCLPHHGLPSHSSVLSPSFQLQSHKNYEGTCEIPESKYSPLGGPKPFECPSIQITSISPNCHQELDAHEDDLQINDPEREFLERPSRDHLYLPLEPSYRESSLSPSPASSISSRSWFSDASSCESLSHIYDDVDSELNEAAARFTLGSPLTSPGGSPGGCPGEETWHQQYGLGHSLSPRQSPCHSPRSSVTDENWLSPRPASGPSSRPTSPCGKRRHSSAEVCYAGSLSPHHSPVPSPGHSPRGSVTEDTWLNASVHGGSGLGPAVFPFQYCVETDIPLKTRKTSEDQAAILPGKLELCSDDQGSLSPARETSIDDGLGSQYPLKKDSCGDQFLSVPSPFTWSKPKPGHTPIFRTSSLPPLDWPLPAHFGQCELKIEVQPKTHHRAHYETEGSRGAVKASTGGHPVVKLLGYNEKPINLQMFIGTADDRYLRPHAFYQVHRITGKTVATASQEIIIASTKVLEIPLLPENNMSASIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHIPQPSGKVLSLQIASIPVECSQRSAQELPHIEKYSINSCSVNGGHEMVVTGSNFLPESKIIFLEKGQDGRPQWEVEGKIIREKCQGAHIVLEVPPYHNPAVTAAVQVHFYLCNGKRKKSQSQRFTYTPVLMKQEHREEIDLSSVPSLPVPHPAQTQRPSSDSGCSHDSVLSGQRSLICSIPQTYASMVTSSHLPQLQCRDESVSKEQHMIPSPIVHQPFQVTPTPPVGSSYQPMQTNVVYNGPTCLPINAASSQEFDSVLFQQDATLSGLVNLGCQPLSSIPFHSSNSGSTGHLLAHTPHSVHTLPHLQSMGYHCSNTGQRSLSSPVADQITGQPSSQLQPITYGPSHSGSATTASPAASHPLASSPLSGPPSPQLQPMPYQSPSSGTASSPSPATRMHSGQHSTQAQSTGQGGLSAPSSLICHSLCDPASFPPDGATVSIKPEPEDREPNFATIGLQDITLDDVNEIIGRDMSQISVSQGAGVSRQAPLPSPESLDLGRSDGL", "length": 1075 }, "evidence": [ { "id": "47563449", "url": "http://www.informatics.jax.org/homology/47563449", "database": "MGI" }, { "id": "A0A0G2JTY4", "url": "https://omabrowser.org/oma/group/A0A0G2JTY4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 31, "go_terms": [ { "name": "myotube cell development", "id": "GO:0014904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014904", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "pmid": "" }, { "name": "vascular associated smooth muscle cell differentiation", "id": "GO:0035886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035886", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "pmid": "" }, { "name": "negative regulation of vascular associated smooth muscle cell differentiation", "id": "GO:1905064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905064", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "pmid": "" }, { "name": "heart development", "id": "GO:0007507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007507", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "pmid": "" }, { "name": "positive regulation of apoptotic process", "id": "GO:0043065", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043065", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "pmid": "" }, { "name": "positive regulation of nitric oxide biosynthetic process", "id": "GO:0045429", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045429", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "pmid": "" }, { "name": "response to hypoxia", "id": "GO:0001666", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001666", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "pmid": "" }, { "name": "blood vessel remodeling", "id": "GO:0001974", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001974", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "pmid": "" }, { "name": "cellular response to calcium ion", "id": "GO:0071277", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071277", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "pmid": "" }, { "name": "positive regulation of DNA-templated transcription", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "pmid": "" }, { "name": "skeletal muscle fiber development", "id": "GO:0048741", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048741", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "pmid": "" }, { "name": "thymus development", "id": "GO:0048538", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048538", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "pmid": "" }, { "name": "transcription by RNA polymerase II", "id": "GO:0006366", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006366", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "pmid": "" }, { "name": "cardiac muscle hypertrophy in response to stress", "id": "GO:0014898", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014898", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "pmid": "" }, { "name": "branching involved in blood vessel morphogenesis", "id": "GO:0001569", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001569", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "pmid": "" }, { "name": "vascular associated smooth muscle cell development", "id": "GO:0097084", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097084", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "pmid": "" }, { "name": "positive regulation of cardiac muscle hypertrophy", "id": "GO:0010613", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010613", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "pmid": "" }, { "name": "regulation of store-operated calcium entry", "id": "GO:2001256", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001256", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "pmid": "" }, { "name": "myotube differentiation", "id": "GO:0014902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014902", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "pmid": "" }, { "name": "T cell differentiation", "id": "GO:0030217", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030217", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "pmid": "" }, { "name": "positive thymic T cell selection", "id": "GO:0045059", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045059", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "pmid": "" }, { "name": "calcineurin-NFAT signaling cascade", "id": "GO:0033173", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033173", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "pmid": "" }, { "name": "cellular response to lithium ion", "id": "GO:0071285", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071285", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "pmid": "" }, { "name": "protein import into nucleus", "id": "GO:0006606", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006606", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "pmid": "" }, { "name": "cellular respiration", "id": "GO:0045333", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045333", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "pmid": "" }, { "name": "negative regulation of miRNA transcription", "id": "GO:1902894", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902894", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "pmid": "" }, { "name": "positive regulation of artery morphogenesis", "id": "GO:1905653", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905653", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "pmid": "" }, { "name": "DN4 thymocyte differentiation", "id": "GO:1904157", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904157", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 11, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "pmid": "" }, { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": 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