{ "uniprot_canonical_ac": "A0A0G2JTM6-1", "uniprot_ac": "A0A0G2JTM6", "uniprot_id": "A0A0G2JTM6_RAT", "mass": { "chemical_mass": 78759.0, "monoisotopic_mass": 78759.0 }, "refseq": { "ac": "XP_006235485", "name": "probable ATP-dependent RNA helicase DHX35 isoform 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006235485" }, "gene_names": [ { "name": "Dhx35", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A0G2JTM6", "id": "A0A0G2JTM6" }, { "name": "Dhx35", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006235485", "id": "XP_006235485" } ], "protein_names": [ { "name": "RNA helicase", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JTM6/entry#names_and_taxonomy", "id": "A0A0G2JTM6" }, { "name": "3.6.4.13", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JTM6/entry#names_and_taxonomy", "id": "A0A0G2JTM6" }, { "name": "probable ATP-dependent RNA helicase DHX35 isoform 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006235485", "id": "XP_006235485" }, { "name": "probable ATP-dependent RNA helicase DHX35; DEAH (Asp-Glu-Ala-His) box polypeptide 35", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006235485", "id": "XP_006235485" } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTM6", "url": "https://www.uniprot.org/uniprot/A0A0G2JTM6" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "gene": [ { "name": "Dhx35", "url": "https://www.uniprot.org/uniprot/A0A0G2JTM6", "locus": { "chromosome": "3", "start_pos": 147507451, "end_pos": 147450163, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000015928", "url": "https://www.ensembl.org/id/ENSRNOG00000015928" } ] } } ], "crossref": [ { "id": "A0A0G2JTM6", "url": "https://alphafold.ebi.ac.uk/entry/A0A0G2JTM6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSRNOG00000015928", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000015928", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd17980", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17980", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd18791", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18791", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "362260", "url": "https://www.ncbi.nlm.nih.gov/gene/362260", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001650", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001650", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002464", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002464", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007502", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007502", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011709", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011709", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014001", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014001", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:362260", "url": "https://www.genome.jp/dbget-bin/www_bget?rno:362260", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FHEVMET", "url": "https://omabrowser.org/oma/group/FHEVMET/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A0G2JTM6", "url": "https://www.orthodb.org/?gene=A0A0G2JTM6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "D4AEG5", "url": "https://www.orthodb.org/?gene=D4AEG5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR18934", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18934", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR18934:SF136", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18934:SF136", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00271", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00271", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF04408", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04408", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF07717", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07717", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF21010", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21010", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-72163", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-72163", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "XP_006235485", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006235485", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "1311165", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1311165", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "13065", "url": "https://www.rhea-db.org/rhea/13065", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A0G2JTM6", "url": "https://www.uniprot.org/uniprot/A0A0G2JTM6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2JTM6-1", "url": "https://www.uniprot.org/uniprot/A0A0G2JTM6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D4AEG5", "url": "https://www.uniprot.org/uniprot/D4AEG5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D4AEG5-1", "url": "https://www.uniprot.org/uniprot/D4AEG5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAPLGPVKFWKPGTEGPGVSISEERQSVTENSGTTVIYNPYAALSIEQQRQKLPVFKLRNHILYLVENYQTVVIVGETGCGKSTQVPQYLAEAGWTAEGRVVGVTQPRRVAAVTVAGRVADERGAVLGHEVGYCIRFDDCTDPLATRIKFLTDGMLVREMMVDPLLTKYSVVMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDAEKFRDFFNQNETSDPARDTCVILTVEGRTFPVDIFYLQSPVPDYIKATVDTVVKIHQTEGDGDILAFLTGQEEVETVVSMLIEQARALARTGMKKHLRVLPMYAGLPSFEQMKVFERVSHSVRKVIVATNVAETSITISGIVYVIDCGFMKLRAYNPRTAIECLVVVPVSQASANQRAGRGGRNRSGKCYRLYTEEAFEQLPQSTVPEMQRSNLAPVVLQLKALGIDSVLRFHFMSPPPAQSMVQALELLYALGGLDKDCRLTEPLGMRIAEFPLNPMFAKMLLESGNFGCSQEILSIAAMMQIQNVFVFPSNQKSQATRVHRKFAVEEGDHLTMLNVYEAFIKHNKSSQWCQEHFLNYKGLVRAATVRDQLKKLLVKFQVPKMSSEGDPDPVLRCIVSGFFANAARFHSTGAYRTIRDDHELHIHPASVLYAEKPPRWVIYNEVIQTSKYYMRDVTAIESAWLLELAPHFYQQGTHLSLKAKRAKVQDQ", "length": 703, "header": "tr|A0A0G2JTM6-1|A0A0G2JTM6_RAT Isoform 1 of RNA helicase OS=Rattus norvegicus OX=10116 GN=Dhx35 PE=4 SV=1 CANONICAL=A0A0G2JTM6-1" }, "isoforms": [ { "isoform_ac": "A0A0G2JTM6-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JTM6/entry#A0A0G2JTM6-1", "sequence": { "sequence": "MAAPLGPVKFWKPGTEGPGVSISEERQSVTENSGTTVIYNPYAALSIEQQRQKLPVFKLRNHILYLVENYQTVVIVGETGCGKSTQVPQYLAEAGWTAEGRVVGVTQPRRVAAVTVAGRVADERGAVLGHEVGYCIRFDDCTDPLATRIKFLTDGMLVREMMVDPLLTKYSVVMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDAEKFRDFFNQNETSDPARDTCVILTVEGRTFPVDIFYLQSPVPDYIKATVDTVVKIHQTEGDGDILAFLTGQEEVETVVSMLIEQARALARTGMKKHLRVLPMYAGLPSFEQMKVFERVSHSVRKVIVATNVAETSITISGIVYVIDCGFMKLRAYNPRTAIECLVVVPVSQASANQRAGRGGRNRSGKCYRLYTEEAFEQLPQSTVPEMQRSNLAPVVLQLKALGIDSVLRFHFMSPPPAQSMVQALELLYALGGLDKDCRLTEPLGMRIAEFPLNPMFAKMLLESGNFGCSQEILSIAAMMQIQNVFVFPSNQKSQATRVHRKFAVEEGDHLTMLNVYEAFIKHNKSSQWCQEHFLNYKGLVRAATVRDQLKKLLVKFQVPKMSSEGDPDPVLRCIVSGFFANAARFHSTGAYRTIRDDHELHIHPASVLYAEKPPRWVIYNEVIQTSKYYMRDVTAIESAWLLELAPHFYQQGTHLSLKAKRAKVQDQ", "length": 703, "header": "tr|A0A0G2JTM6-1|A0A0G2JTM6_RAT Isoform 1 of RNA helicase OS=Rattus norvegicus OX=10116 GN=Dhx35 PE=4 SV=1 CANONICAL=A0A0G2JTM6-1" }, "locus": { "chromosome": "3", "start_pos": 147506370, "end_pos": 147450232, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000084866.2", "url": "https://www.ensembl.org/id/ENSRNOT00000084866.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000068770.1", "url": "https://www.ensembl.org/id/ENSRNOP00000068770.1" } ] } }, { "isoform_ac": "D4AEG5-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JTM6/entry#D4AEG5-1", "sequence": { "sequence": "MAAPLGPVKFWKPGTEGPGVSISEERQSVTENSGTTVIYNPYAALSIEQQRQKLPVFKLRNHILYLVENYQTVVIVGETGCGKSTQVPQYLAEAGWTAEGRVVGVTQPRRVAAVTVAGRVADERGAVLGHEVGYCIRFDDCTDPLATRIKFLTDGMLVREMMVDPLLTKYSVVMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDAEKFRDFFNQNETSDPARDTCVILTVEGRTFPVDIFYLQSPVPDYIKATVDTVVKIHQTEGDGDILAFLTGQEEVETVVSMLIEQARALARTGMKKHLRVLPMYAGLPSFEQMKVFERVSHSVRKVIVATNVAETSITISGIVYVIDCGFMKLRAYNPRTAIECLVVVPVSQASANQRAGRGGRNRSGKCYRLYTEEAFEQLPQSTVPEMQRSNLAPVVLQLKALGIDSVLRFHFMSPPPAQSMVQALELLYALGGLDKDCRLTEPLGMRIAEFPLNPMFAKMLLESGNFGCSQEILSIAAMMQIQNVFVFPSNQKSQATRVHRKFAVEEGDHLTMLNVYEAFIKHNKSSQWCQEHFLNYKGLVRAATVRDQLKKLLVKFQVPKMSSEGDPDPVLRCIVSGFFANAARFHSTGAYRVIYNEVIQTSKYYMRDVTAIESAWLLELAPHFYQQGTHLSLKAKRAKVQDQ", "length": 679, "header": "tr|D4AEG5-1|A0A0G2JTM6_RAT Computationally mapped isoform of RNA helicase OS=Rattus norvegicus OX=10116 GN=Dhx35 PE=4 SV=1 CANONICAL=A0A0G2JTM6-1" }, "locus": { "chromosome": "3", "start_pos": 147506370, "end_pos": 147450232, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000021435.6", "url": "https://www.ensembl.org/id/ENSRNOT00000021435.6" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000021435.4", "url": "https://www.ensembl.org/id/ENSRNOP00000021435.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool": "isoglyp", "mining_tool": "", "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "start_pos": 115, "start_aa": "T", "end_pos": 115, "end_aa": "T", "residue": "Thr", "site_lbl": "Thr115", "evidence": [ { "id": "GLY_001157", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001157" } ], "filter_code": "00000000000000001000.00000000001000.1.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "rno:362260", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?rno:362260", "resource": "KEGG Pathway" }, { "id": "R-RNO-72163", "name": "mRNA Splicing - Major Pathway", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-72163", "resource": "Reactome", "description": "mRNA Splicing - Major Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0ZUF1-1", "protein_name": "RNA helicase", "gene_name": "DHX35", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAAPVGPVKFWKPGTEGPGVSVSEERQSPAESSGVTVVYNPYASLSIEQQRQKLPVFKLRNHILYLVESYQTLVIVGETGCGKSTQIPQYLAEAGWTAEGRVVGVTQPRRVAAVSVAGRVADERGAVLGHEVGYCIRFDDCTDPQATRIKFLTDGMLVREMMADPLLTRYSVLMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDAEKFRDFFNQNDTGDPSKDTSVILTVEGRTFPVDIFYIQSPVPDYIKSTVETAMKIHQMENDGDILAFLTGQEEVETVVSMLIEQARALSRTGMRKHLRVLPMYAGLPSPDQMKVFERVSRSVRKVIVATNVAETSITIHGIAYVIDCGFVKLRAYNPKTAIECLVVVPVSKASANQRAGRAGRNRSGKCYRLYTEEDFEKLPQSTVPEMQRSNLAPVILQLKALGIDNVLRFPFLSPPPAQSMVQALELLYALGGLDMHCRLTEPLGMRIAEFPLNPMFAKMLLESGNFGCSQEILTIAAMMQIQNIFLIPPNQKSQAARQHRKFAVEEGDHLTMLNVYEAFVKHSKSSQWCQEHFLNYKGLVRASVVREQLKKLLVRFKVPKKSSEGDPDPVLRCIVSGFFANAAKFHSTGAYRTIRDDHELHIHPTSVLYAEKPPRWVVYNEVIQTAKYYMRDVTAIESAWLVELAPHFYQQGTVRNRHKAQTHLSLNAKRAKVDDH", "length": 712 }, "evidence": [ { "id": "A0A0G2JTM6", "url": "https://omabrowser.org/oma/group/A0A0G2JTM6/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0AAA9SQM0-1", "protein_name": "RNA helicase", "gene_name": "DHX35", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MAAPVGPVKFWRPGTEGPGVSISEERQSLAENSATTVVYNPYAALSIEQQRQKLPVFKLRNHILYLIENYQTVVIIGETGCGKSTQIPQYLAEAGWTAEGRVVGVTQPRRVAAVTVAGRVAEERGAVLGHEVGYCIRFDDCTNPLATRIKFLTDGMLVREMMVDPLLTKYSAIMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDAEKFRDFFNHNDTSDPTRDTCVILTVEGRTFPVDIFYLQSPVPDYIKSTVETVMKIHQTEGDGDILAFLTGQEEVETVVSMLIEQARALGQTGMKRHLRILPMYAGLPSFEQMKVFERVSRSVRKVIVATNVAETSITISGIVYVIDCGFVKLRAYNPRTAIECLVVVPVSQASANQRAGRGGRSRSGKCYRLYTEEAFDQLPQSTVPEMQRSNLAPVILQLKALGIDNVLRFHFMSPPPAQSMVQALELLYALGGLDKDCRLTEPLGMRIAEFPLNPMFAKMLLESGNFGCSQEILSIAAMMQIQNVFVVPSNQKSQAIRAHRKFAVEEGDHLTMLNVYEAFIKHNKNSQWCQEHFLNYKGLVRAATVREQLKKLLVKFQVPKKSSEGDPDPVLRCIVSGFFANAARFHSTGAYRTIRDDHELHIHPASVLYAEKPPRWVIYNEVIQTSKYYMRDVTAIESAWLLELAPHFYQQGTVSSSPAPKTWTFDVSTGCLGCSVRPLHSGCAELQCLQHCADLQNLLCTRSQLPSSCSLPALWTLGLHLCGLVFSQRFKSGSSVLISGAPLF", "length": 780 }, "evidence": [ { "id": "A0A0G2JTM6", "url": "https://omabrowser.org/oma/group/A0A0G2JTM6/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "A2ACQ1-1", "protein_name": "RNA helicase", "gene_name": "Dhx35", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAPLGPVKFWKPGTEGPGVSISEERQSVTENSGTTIIYNPYAALSIEQQRQKLPVFKLRNHILYLVENYQTVVIVGETGCGKSTQIPQYLAEAGWTAEGRVVGVTQPRRVAAVTVAGRVADERGAVLGHEVGYCIRFDDCTDPLATRIKFLTDGMLVREMMVDPLLTKYSVIMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDAEKFRDFFNQNETSDPARDTSVTLTVEGRTFPVDIFYLQSPVPDYIKATVDTVVKIHQTEGDGDILAFLTGQEEVETVVSMLIEQARALARTGMKKHLRVLPMYAGLPSFEQMKVFERVSHSVRKVIVATNVAETSITISGIVYVIDCGFMKLRAYNPRTAIECLVVVPVSQASANQRAGRGGRNRSGKCYRLYTEEAFDQLPQSTVPEMQRSNLAPVILQLKALGIDNVLRFHFMSPPPAQSMVQALELLYALGGLDKDCRLTEPLGMRIAEFPLNPMFAKMLLESGNFGCSQEVLSIAAMMQIQNVFVFPSNQKSQATRVHRKFAVEEGDHLTMLNVYEAFIKHNKSSQWCQEHFLNYKGLVRAATVRDQLKKLLVKFQVPKVSSEGDPDPVLRCIVSGFFANAARFHSSGAYRTIRDDHELHIHPASVLYAEKPPRWVIYNEVIQTSKYYMRDVTAIESAWLLELAPHFYQQGTHLSLKAKRAKVQDQ", "length": 703 }, "evidence": [ { "id": "47572089", "url": "http://www.informatics.jax.org/homology/47572089", "database": "MGI" }, { "id": "A0A0G2JTM6", "url": "https://omabrowser.org/oma/group/A0A0G2JTM6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "F4JRJ6-1", "protein_name": "Probable pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH9", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MAFWKPGTEKPRFEEDGEGGIVFMSNNLASSSSSSYGYANIEKQRQRLPVYKYRTEILYLVENHATTIIVGETGSGKTTQIPQYLKEAGWAEGGRVIACTQPRRLAVQAVSARVAEEMGVNLGEEVGYTIRFEDHTTSGVTSVKFLTDGVLIREMMEDPLLTKYSVIMIDEAHERSISTDILLGLLKKIQRRRPELRLIISSATIEAKTMSNFFNSSKKRHAPEGSTPGPKLEPAILSVEGRGFSVKIHYVEEPVSDYIRSVVSTILLINEREPPGDVLVFLTGQEDIETAIKLLEEEAHSNQKNSSGLLPLPLYSGLSRSEQELIFTPTPRGKRKVILSTNIAETSLTLEGVVYVIDSGFSKQKFYNPISDIESLVVAPISKASARQRSGRAGRVRPGKCYRLYTEDYFLNQMPGEGIPEMQRSNLVSTVIQLKALGIDNILGFDWPAPPSSEAMIRALEVLYSLQILDDDAKLTSPTGFQVAELPLDPMISKMILASSELGCSHEIITIAAVLSVQSVWIIARGVQKEQDEAKLRFAAAEGDHVTFLNVYKGFLESKKPTQWCYKNFLNYQSMKKVVEIRDQLKRIARRLGITLKSCDGDMEAVRKAVTAGFFANACRLEPHSNGVYKTIRGSEEVYIHPSSVLFRVNPKWVVYQSIVSTERQYMRNVVTINPSWLTEVAPHFYQNRQNAMSF", "length": 695 }, "evidence": [ { "id": "A0A0G2JTM6", "url": "https://omabrowser.org/oma/group/A0A0G2JTM6/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q55EC3-1", "protein_name": "RNA helicase", "gene_name": "dhx35", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MATNNQINNNSSNNNNNNNNNNSLFDKDSSLSFGNDNFIYNSNQKLTIQQQRISLPIYQNRKHILYLLEKYSTLVIIGNTGCGKSTQIPQYLFESGWSDGFRTILCTQPRRVAAISLAERVAQEMGEQHVGKTVGYSVRFDEKISDIETRIKYVTDGMLIREMMLDPLLLKYSVIMIDEAHERSLQTDLLMGLLKKVQKKRNSTNNNNNNDNSLKLIISSATLNANDFFNFFNYNQTNDKSKDTSTILSIEGRTYPVDIHYLEESTSNYIQTTIQTIIDIHTTQPPGDILVFLTGQEEIEKLIQTLDDKFEILRQYHQQHHHQQQQPFMKYSLLPMYSGLSINKQIKVFESVGDSKKIRKIIISTNIAETSITIDGVVYVVDCGFVKIKSYDSESGLESLVIVPTSKSSANQRAGRAGRSRAGKCYRLYTELTYEKLLPDQTIPEIQRSNLTNTILQLKALGIDNILNFDFISQPPSSSLIRGLEVLYGLGALDDNGKLTNPTGMIMAEFPTDPTFSKMIIQSSSNGFNCSDECITITAMLNIQGLFTNQNHKSRKHLLVKEGDHLTLLNIFNSFISNQSSPQWCNQHQINYKAMQRVLQVRKQLLAYAKKYSINVISCFDSNNNREQCSNLIRKAIVSGFFTNAAQLQPDGSYQTIREKHKLWLHPTSVLCLSNSPQWVIFNEVTITTKEYMKDVTSIEPNWLFEIAPHYYKFKK", "length": 716 }, "evidence": [ { "id": "A0A0G2JTM6", "url": "https://omabrowser.org/oma/group/A0A0G2JTM6/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9H5Z1-1", "protein_name": "Probable ATP-dependent RNA helicase DHX35", "gene_name": "DHX35", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAPVGPVKFWRPGTEGPGVSISEERQSLAENSGTTVVYNPYAALSIEQQRQKLPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPQYLAEAGWTAEGRVVGVTQPRRVAAVTVAGRVAEERGAVLGHEVGYCIRFDDCTDQLATRIKFLTDGMLVREMMVDPLLTKYSVIMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDADKFRDFFNQNETSDPARDTCVILTVEGRTFPVDIFYLQSPVPDYIKSTVETVVKIHQTEGDGDVLAFLTGQEEVETVVSMLIEQARALARTGMKRHLRVLPMYAGLPSFEQMKVFERVSRSVRKVIVATNVAETSITISGIVYVIDCGFVKLRAYNPRTAIECLVVVPVSQASANQRAGRGGRSRSGKCYRLYTEEAFDKLPQSTVPEMQRSNLAPVILQLKALGIDNVLRFHFMSPPPAQSMVQALELLYALGGLDKDCRLTEPLGMRIAEFPLNPMFAKMLLESGNFGCSQEILSIAAMMQIQNIFVVPPNQKSHAIRVHRKFAVEEGDHLTMLNIYEAFIKHNKDSKWCQEHFLNYKGLVRAATVREQLKKLLVKFQVPRKSSEGDPDLVLRCIVSGFFANAARFHSTGAYRTIRDDHELHIHPASVLYAEKPPRWVIYNEVIQTSKYYMRDVTAIESAWLLELAPHFYQQGTHLSLKAKRAKVQDP", "length": 703 }, "evidence": [ { "id": "47572089", "url": "http://www.informatics.jax.org/homology/47572089", "database": "MGI" }, { "id": "A0A0G2JTM6", "url": "https://omabrowser.org/oma/group/A0A0G2JTM6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VR29-1", "protein_name": "RNA helicase", "gene_name": "cg3225", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSTFKPKFLKPETDDAITDSAGGEQQSSAFVFNVNHNMGLMEQRERLPIRQYRDQILYCLEKHQVVILVGETGSGKSTQVPQYLYEWGWHTKGLIGITEPRRVSTVTLANRVAQERGELVGDTVGYVVRFLESMSSCTKIKFMTEGILLREVLADPLLTQYGVIIVDEAHERNMLTDMILGLLKKILRKRSSLKLIISSATIDASFFSEFFSWPGSGEVSVKLSIEGRMHPVSNFYLNEPCADYVKETVETVWKLHQKEPPGDILAFLTGQEEVLEALDLLREYIASSEQENLKVLPMYGSMSSTDQLSVFFTPPKGTRKVVLATNIAETSITIPGIVYVIDCGYVKVKWYNPKTCSDSLVIVPVSKASAIQRAGRAGRMRPGKVYRLYTKSDYEALAPRQPPEMRRSELSGAILQLKALGIGNILRFDFPSPPPAQNLLSALESLFALDAIDEQGNLTKPVGYLLAELPFSAMLSKMLYVSGQMGCSEEIITIIALLQVQSIFSRPASAVAQQSGRIAHRKFEVAEGDFITMLNAYTGFVEEGMTKEFCGQYFLIYRNLKRAHSLREQLITVARKKYGIPIFSCKGDVEKLCKCITAGFFTQVAYLHHSGVYRQISSGTELAIHPNSTLYTLPQAQYVVYGELLQTTKLFMNYVTVIKREWLTELAPHYYQQTTVRD", "length": 678 }, "evidence": [ { "id": "A0A0G2JTM6", "url": "https://omabrowser.org/oma/group/A0A0G2JTM6/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "in utero embryonic development", "id": "GO:0001701", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001701", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTM6", "url": "https://www.uniprot.org/uniprot/A0A0G2JTM6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTM6", "url": "https://www.uniprot.org/uniprot/A0A0G2JTM6" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTM6", "url": "https://www.uniprot.org/uniprot/A0A0G2JTM6" } ], "pmid": "" }, { "name": "hydrolase activity", "id": "GO:0016787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016787", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTM6", "url": "https://www.uniprot.org/uniprot/A0A0G2JTM6" } ], "pmid": "" }, { "name": "helicase activity", "id": "GO:0004386", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004386", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTM6", "url": "https://www.uniprot.org/uniprot/A0A0G2JTM6" } ], "pmid": "" }, { "name": "RNA helicase activity", "id": "GO:0003724", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003724", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTM6", "url": "https://www.uniprot.org/uniprot/A0A0G2JTM6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "catalytic step 2 spliceosome", "id": "GO:0071013", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071013", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTM6", "url": "https://www.uniprot.org/uniprot/A0A0G2JTM6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 223, "end_pos": 225, "annotation": "n_glycosylation_sequon" }, { "start_pos": 397, "end_pos": 399, "annotation": "n_glycosylation_sequon" }, { "start_pos": 559, "end_pos": 561, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "13065", "name": "", "equation": "ATP + H2O = ADP + H(+) + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "D3ZD32-1", "D4A523-1", "Q3MHU3-1", "F1M298-1", "Q5RJZ1-1", "P60123-1", "Q793F9-1", "F1LPQ2-1", "G3V681-1", "F1LNJ2-1", "D4A2Z8-1", "Q5RKI1-1", "P70486-1", "Q66HG7-1", "Q99PT0-1", "D3ZG52-1", "Q5U216-1", "Q62780-1", "Q641Y8-1", "Q5BJS0-1", "Q63413-1", "Q64060-1", "Q9JIX5-1", "P06761-1", "Q6GX84-1", "Q5XI69-1", "Q9QUL6-1", "Q1HG60-1", "Q3B8Q2-1", "P46462-1", "D3ZA12-1", "D3Z9Z9-1", "Q68G38-1", "Q9QY16-1", "A0A8I5ZZZ0-1", "A0A0G2K0H9-1", "Q62724-1", "Q5EBA1-1", "Q3B8Q1-1", "Q9EQN5-1", "F1M9L4-1", "F1M5F3-1", "D3ZFP4-1", "F1MA70-1", "D3ZBY5-1", "D3ZVK1-1", "D3ZX56-1", "B1H269-1", "Q9WTT2-1", "G3V8T5-1", "Q8CG07-1", "B2GUX3-1", "P08289-1", "D3ZP96-1", "D3ZHW0-1", "Q5XIR6-1", "A0A8I6AFW4-1", "Q5XI46-1", "A0A0G2KA92-1", "D4AAG9-1", "A0A096MJV7-1", "A0A0G2JTM6-1", "A0A8I5ZKV9-1", "A0A8I5ZKH1-1", "D3ZD46-1", "A0A8I6GIY0-1", "E9PU01-1", "A0A8I6ABZ7-1", "D3ZAP7-1", "D4A321-1", "A0A0G2K283-1", "Q6MG13-1", "P62738-1", "P63259-1", "P68035-1", "P68136-1", "P60711-1", "P63269-1", "P56536-1", "P54777-1", "D3ZSV6-1", "D3ZUC2-1", "G3V6W5-1", "D3ZD97-1", "D3ZEG9-1", "A6KAR2-1", "P63018-1", "P82995-1", "D4ADT5-1", "D4A6Q6-1", "A0A8I5ZMZ5-1", "A0A8I6GIN4-1", "A6KSS8-1", "D4A2B7-1", "A0A8I6AK63-1", "A0A0G2K4S4-1", "F1LTR3-1", "F1LWY1-1", "D4A1R0-1", "P97687-1", "Q9JIL8-1", "Q925S8-1", "Q6AYJ1-1", "D4ACP5-1", "Q641Z7-1", "Q5EB68-1", "D3ZQW1-1", "Q4G005-1", "M0RCB1-1", "A0A8I6AGW3-1", "A0A8I6AQL9-1", "Q5BKE0-1", "F1LTH9-1", "P34158-1", "Q7TT47-1", "F1M3J4-1" ], "evidence": [ { "id": "13065", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/13065" } ] }, { "id": "R-RNO-9770141", "name": "Formation of the Spliceosomal C* complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [ "R-RNO-5688092", "R-RNO-5688093", "R-RNO-72073", "R-RNO-9769591", "R-RNO-9769593", "R-RNO-9769594", "R-RNO-9769596", "R-RNO-9769598", "R-RNO-9769599", "R-RNO-9769601" ], "output_participant_list": [ "R-RNO-72060", "R-RNO-8867898", "R-RNO-9770419", "R-RNO-9770425", "R-RNO-9770427", "R-RNO-9770428", "R-RNO-9770430" ], "enzyme_list": [ "Q9JMJ4-1", "P63018-1", "Q62780-1", "F1LNJ2-1", "A0A8I5ZKV9-1", "A0A0G2K283-1", "G3V8Y5-1", "A0A0G2JTM6-1", "D4A5A6-1", "D4A321-1", "Q4KLI4-1", "Q3B8Q2-1", "D3ZD97-1", "Q63413-1", "Q812D3-1", "D4AEG3-1", "F7FHL6-1" ], "evidence": [ { "id": "R-RNO-9770141", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9770141" } ] } ], "reaction_participants": [ { "participant_id": "R-RNO-5688092", "participant_name": "Dhx8 [nucleoplasm]", "crossref": [ { "id": "ENSRNOT00000086892", "database": "Ensembl", "url": "" }, { "id": "ENSRNOP00000072141", "database": "Ensembl", "url": "" }, { "id": "A0A0G2K283", "database": "UniProt", "url": "" }, { "id": "ENSRNOG00000020772", "database": "Ensembl", "url": "" }, { "id": "1310723", "database": "RGD", "url": "" } ] }, { "participant_id": "R-RNO-5688093", "participant_name": "Prpf18 [nucleoplasm]", "crossref": [ { "id": "708550", "database": "RGD", "url": "" }, { "id": "Q9JKB8", "database": "PRO", "url": "" }, { "id": "ENSRNOT00000024872", "database": "Ensembl", "url": "" }, { "id": "ENSRNOG00000018396", "database": "Ensembl", "url": "" }, { "id": "ENSRNOP00000024872", "database": "Ensembl", "url": "" }, { "id": "Q9JKB8", "database": "UniProt", "url": "" }, { "id": "NP_612532.1", "database": "RefSeq", "url": "" } ] }, { "participant_id": "R-RNO-72060", "participant_name": "Dhx38 [nucleoplasm]", "crossref": [ { "id": "D4A321", "database": "UniProt", "url": "" }, { "id": "NP_001099655.1", "database": "RefSeq", "url": "" }, { "id": "1310345", "database": "RGD", "url": "" }, { "id": "ENSRNOP00000019810", "database": "Ensembl", "url": "" }, { "id": "ENSRNOT00000019810", "database": "Ensembl", "url": "" }, { "id": "ENSRNOG00000014619", "database": "Ensembl", "url": "" } ] }, { "participant_id": "R-RNO-72073", "participant_name": "Slu7 [nucleoplasm]", "crossref": [ { "id": "XP_008765864.1", "database": "RefSeq", "url": "" }, { "id": "ENSRNOT00000005132", "database": "Ensembl", "url": "" }, { "id": "Q80ZG5", "database": "UniProt", "url": "" }, { "id": "Q80ZG5", "database": "PRO", "url": "" }, { "id": "631432", "database": "RGD", "url": "" }, { "id": "ENSRNOP00000005132", "database": "Ensembl", "url": "" }, { "id": "ENSRNOG00000003822", "database": "Ensembl", "url": "" }, { "id": "NP_001094020.1", "database": "RefSeq", "url": "" } ] }, { "participant_id": "R-RNO-8867898", "participant_name": "Cwc25 [nucleoplasm]", "crossref": [ { "id": "A0A8I5ZK98", "database": "UniProt", "url": "" }, { "id": "1305258", "database": "RGD", "url": "" }, { "id": "ENSRNOT00000104055", "database": "Ensembl", "url": "" }, { "id": "ENSRNOP00000077307", "database": "Ensembl", "url": "" }, { "id": "ENSRNOG00000004091", "database": "Ensembl", "url": "" } ] }, { "participant_id": "R-RNO-9769591", "participant_name": "Cactin [nucleoplasm]", "crossref": [ { "id": "ENSRNOP00000027926", "database": "Ensembl", "url": "" }, { "id": "1563634", "database": "RGD", "url": "" }, { "id": "ENSRNOG00000039852", "database": "Ensembl", "url": "" }, { "id": "ENSRNOT00000027926", "database": "Ensembl", "url": "" }, { "id": "B2GUU0", "database": "UniProt", "url": "" } ] }, { "participant_id": "R-RNO-9769593", "participant_name": "Sde2 [nucleoplasm]", "crossref": [ { "id": "Q5BJN8", "database": "PRO", "url": "" }, { "id": "Q5BJN8", "database": "UniProt", "url": "" }, { "id": "1305572", "database": "RGD", "url": "" }, { "id": "NP_001020141.2", "database": "RefSeq", "url": "" } ] }, { "participant_id": "R-RNO-9769594", "participant_name": "Prkrip1 [nucleoplasm]", "crossref": [ { "id": "ENSRNOP00000081998", "database": "Ensembl", "url": "" }, { "id": "ENSRNOG00000063308", "database": "Ensembl", "url": "" }, { "id": "B0BMS9", "database": "UniProt", "url": "" }, { "id": "ENSRNOT00000103038", "database": "Ensembl", "url": "" }, { "id": "1595708", "database": "RGD", "url": "" }, { "id": "NP_001092263.1", "database": "RefSeq", "url": "" } ] }, { "participant_id": "R-RNO-9769596", "participant_name": "Steep1 [nucleoplasm]", "crossref": [ { "id": "A0A0U1RS26", "database": "UniProt", "url": "" }, { "id": "ENSRNOT00000092455", "database": "Ensembl", "url": "" }, { "id": "1564541", "database": "RGD", "url": "" }, { "id": "ENSRNOG00000012564", "database": "Ensembl", "url": "" }, { "id": "ENSRNOP00000075907", "database": "Ensembl", "url": "" } ] }, { "participant_id": "R-RNO-9769598", "participant_name": "Fam32a [nucleoplasm]", "crossref": [ { "id": "NP_001121550.1", "database": "RefSeq", "url": "" }, { "id": "1561287", "database": "RGD", "url": "" }, { "id": "B2RYG1", "database": "UniProt", "url": "" }, { "id": "B2RYG1", "database": "PRO", "url": "" } ] }, { "participant_id": "R-RNO-9769599", "participant_name": "Fam50a [nucleoplasm]", "crossref": [ { "id": "ENSRNOG00000058439", "database": "Ensembl", "url": "" }, { "id": "ENSRNOP00000071078", "database": "Ensembl", "url": "" }, { "id": "ENSRNOT00000086921", "database": "Ensembl", "url": "" }, { "id": "G3V9M8", "database": "UniProt", "url": "" }, { "id": "XP_003749827.1", "database": "RefSeq", "url": "" }, { "id": "1560964", "database": "RGD", "url": "" }, { "id": "NP_001164044.1", "database": "RefSeq", "url": "" } ] }, { "participant_id": "R-RNO-9769601", "participant_name": "DDX41 [nucleoplasm]", "crossref": [ { "id": "NP_001101516.1", "database": "RefSeq", "url": "" }, { "id": "ENSRNOP00000018114", "database": "Ensembl", "url": "" }, { "id": "B2RYL8", "database": "UniProt", "url": "" }, { "id": "1311758", "database": "RGD", "url": "" }, { "id": "ENSRNOT00000018114", "database": "Ensembl", "url": "" }, { "id": "ENSRNOG00000012771", "database": "Ensembl", "url": "" } ] }, { "participant_id": "R-RNO-9770419", "participant_name": "Gpatch1 [nucleoplasm]", "crossref": [ { "id": "F1LU70", "database": "UniProt", "url": "" }, { "id": "ENSRNOP00000015791", "database": "Ensembl", "url": "" }, { "id": "ENSRNOT00000015791", "database": "Ensembl", "url": "" }, { "id": "1308935", "database": "RGD", "url": "" }, { "id": "NP_001099716.1", "database": "RefSeq", "url": "" }, { "id": "ENSRNOG00000011584", "database": "Ensembl", "url": "" } ] }, { "participant_id": "R-RNO-9770425", "participant_name": "Wdr70 [nucleoplasm]", "crossref": [ { "id": "Q5EB92", "database": "UniProt", "url": "" }, { "id": "ENSRNOT00000060146", "database": "Ensembl", "url": "" }, { "id": "NP_001013931.1", "database": "RefSeq", "url": "" }, { "id": "1309487", "database": "RGD", "url": "" }, { "id": "Q5EB92", "database": "PRO", "url": "" }, { "id": "ENSRNOG00000013336", "database": "Ensembl", "url": "" }, { "id": "ENSRNOP00000056890", "database": "Ensembl", "url": "" } ] }, { "participant_id": "R-RNO-9770427", "participant_name": "Dhx35 [nucleoplasm]", "crossref": [ { "id": "A0A0G2JTM6", "database": "UniProt", "url": "" }, { "id": "ENSRNOT00000084866", "database": "Ensembl", "url": "" }, { "id": "ENSRNOG00000015928", "database": "Ensembl", "url": "" }, { "id": "1311165", "database": "RGD", "url": "" }, { "id": "XP_006235485.1", "database": "RefSeq", "url": "" }, { "id": "ENSRNOP00000068770", "database": "Ensembl", "url": "" } ] }, { "participant_id": "R-RNO-9770428", "participant_name": "Nsrp1 [nucleoplasm]", "crossref": [ { "id": "Q4FZU3", "database": "UniProt", "url": "" }, { "id": "NP_001032266.1", "database": "RefSeq", "url": "" }, { "id": "ENSRNOG00000062400", "database": "Ensembl", "url": "" }, { "id": "ENSRNOT00000107073", "database": "Ensembl", "url": "" }, { "id": "ENSRNOP00000087935", "database": "Ensembl", "url": "" }, { "id": "1309863", "database": "RGD", "url": 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"3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "B2GUX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2GUX3" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "B2GUX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2GUX3" } ] } ] }, { "uniprot_ac": "D3Z9Z9", "gene_name": "Smarcad1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3Z9Z9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z9Z9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D3Z9Z9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z9Z9" } ] } ] }, { "uniprot_ac": "D3ZA12", "gene_name": "Chd6", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZA12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZA12" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D3ZA12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZA12" } ] } ] }, { "uniprot_ac": "D3ZAP7", "gene_name": "Chd7", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZAP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZAP7" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D3ZAP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZAP7" } ] } ] }, { "uniprot_ac": "D3ZBY5", "gene_name": "Ddx10", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZBY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZBY5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D3ZBY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZBY5" } ] } ] }, { "uniprot_ac": 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"https://www.uniprot.org/uniprot/D3ZHW0" } ] } ] }, { "uniprot_ac": "D3ZP96", "gene_name": "Mcm2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZP96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZP96" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D3ZP96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZP96" } ] } ] }, { "uniprot_ac": "D3ZQW1", "gene_name": "Blm", "activity": [ { "ec_number": "5.6.2.4", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.", "evidence": [ { "id": "D3ZQW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZQW1" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "D3ZQW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZQW1" } ] } ] }, { "uniprot_ac": "D3ZSV6", "gene_name": "Dhx33", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZSV6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZSV6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D3ZSV6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZSV6" } ] } ] }, { "uniprot_ac": "D3ZUC2", "gene_name": "Mov10", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZUC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZUC2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D3ZUC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZUC2" } ] } ] }, { "uniprot_ac": "D3ZVK1", "gene_name": "Mcm8", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZVK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZVK1" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D3ZVK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZVK1" } ] } ] }, { "uniprot_ac": "D3ZX56", "gene_name": "Ddx55", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZX56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZX56" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D3ZX56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZX56" } ] } ] }, { "uniprot_ac": "D4A1R0", "gene_name": "Dhx37", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D4A1R0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A1R0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D4A1R0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A1R0" } ] } ] }, { "uniprot_ac": "D4A2B7", "gene_name": "Afg2b", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D4A2B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A2B7" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "D4A2B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A2B7" } ] } ] }, { "uniprot_ac": "D4A2Z8", "gene_name": "Dhx36", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D4A2Z8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A2Z8" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D4A2Z8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A2Z8" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D4A2Z8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A2Z8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D4A2Z8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A2Z8" } ] } ] }, { "uniprot_ac": "D4A321", "gene_name": "Dhx38", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D4A321", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A321" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D4A321", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A321" } ] } ] }, { "uniprot_ac": "D4A523", "gene_name": "Nlrp3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "D4A523", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A523" } ] } ] }, { "uniprot_ac": "D4A5A6", "gene_name": "Polr2a", "activity": [ { "ec_number": "2.7.7.6", "activity": "a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1).", "evidence": [ { "id": "D4A5A6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A5A6" } ] }, { "ec_number": "2.7.7.6", "activity": "", "evidence": [ { "id": "D4A5A6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A5A6" } ] } ] }, { "uniprot_ac": "D4A6Q6", "gene_name": "Ino80", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "D4A6Q6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A6Q6" } ] } ] }, { "uniprot_ac": "D4AAG9", "gene_name": "Chd1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D4AAG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4AAG9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D4AAG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4AAG9" } ] } ] }, { "uniprot_ac": "D4ACP5", "gene_name": "Recql5", "activity": [ { "ec_number": "5.6.2.4", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.", "evidence": [ { "id": "D4ACP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ACP5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "D4ACP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ACP5" } ] } ] }, { "uniprot_ac": "D4ADT5", "gene_name": "Rig1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D4ADT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ADT5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D4ADT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ADT5" } ] } ] }, { "uniprot_ac": "D4AEG3", "gene_name": "Ppil4", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "D4AEG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4AEG3" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "D4AEG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4AEG3" } ] } ] }, { "uniprot_ac": "E9PU01", "gene_name": "Chd4", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "E9PU01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PU01" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E9PU01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PU01" } ] } ] }, { "uniprot_ac": "F1LNJ2", "gene_name": "Snrnp200", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "F1LNJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LNJ2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1LNJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LNJ2" } ] } ] }, { "uniprot_ac": "F1LPQ2", "gene_name": "Ascc3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "F1LPQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LPQ2" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1LPQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LPQ2" } ] } ] }, { "uniprot_ac": "F1LTH9", "gene_name": "Wrn", "activity": [ { "ec_number": "5.6.2.4", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.", "evidence": [ { "id": "F1LTH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LTH9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1LTH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LTH9" } ] } ] }, { "uniprot_ac": "F1LTR3", "gene_name": "Tdrd12", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "F1LTR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LTR3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1LTR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LTR3" } ] } ] }, { "uniprot_ac": "F1LWY1", "gene_name": "Hfm1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "F1LWY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LWY1" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1LWY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LWY1" } ] } ] }, { "uniprot_ac": "F1M298", "gene_name": "Fbh1", "activity": [ { "ec_number": "5.6.2.4", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.", "evidence": [ { "id": "F1M298", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M298" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1M298", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M298" } ] } ] }, { "uniprot_ac": "F1M3J4", "gene_name": "Abcc4", "activity": [ { "ec_number": "7.6.2.2", "activity": "ATP + daunorubicin(in) + H2O = ADP + daunorubicin(out) + H(+) + phosphate.", "evidence": [ { "id": "F1M3J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M3J4" } ] }, { "ec_number": "7.6.2.-", "activity": "", "evidence": [ { "id": "F1M3J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M3J4" } ] }, { "ec_number": "7.6.2.3", "activity": "an S-substituted glutathione(in) + ATP + H2O = ADP + an S-substituted glutathione(out) + H(+) + phosphate.", "evidence": [ { "id": "F1M3J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M3J4" } ] }, { "ec_number": "7.6.2.2", "activity": "", "evidence": [ { "id": "F1M3J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M3J4" } ] }, { "ec_number": "7.6.2.3", "activity": "", "evidence": [ { "id": "F1M3J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M3J4" } ] }, { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "F1M3J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M3J4" } ] }, { "ec_number": "5.6.1.6", "activity": "", "evidence": [ { "id": "F1M3J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M3J4" } ] } ] }, { "uniprot_ac": "F1M5F3", "gene_name": "Mcm9", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "F1M5F3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M5F3" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1M5F3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M5F3" } ] } ] }, { "uniprot_ac": "F1M9L4", "gene_name": "Atp13a4", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "F1M9L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M9L4" } ] } ] }, { "uniprot_ac": "F1MA70", "gene_name": "Atp13a5", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "F1MA70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1MA70" } ] } ] }, { "uniprot_ac": "F7FHL6", "gene_name": "Ppil2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F7FHL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F7FHL6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F7FHL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F7FHL6" } ] } ] }, { "uniprot_ac": "G3V681", "gene_name": "Mcm4", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "G3V681", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V681" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "G3V681", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V681" } ] } ] }, { "uniprot_ac": "G3V6W5", "gene_name": "Ifih1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "G3V6W5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V6W5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3V6W5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V6W5" } ] } ] }, { "uniprot_ac": "G3V8T5", "gene_name": "Ruvbl2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "G3V8T5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V8T5" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "G3V8T5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V8T5" } ] } ] }, { "uniprot_ac": "G3V8Y5", "gene_name": "Polr2b", "activity": [ { "ec_number": "2.7.7.6", "activity": "a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1).", "evidence": [ { "id": "G3V8Y5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V8Y5" } ] }, { "ec_number": "2.7.7.6", "activity": "", "evidence": [ { "id": "G3V8Y5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V8Y5" } ] } ] }, { "uniprot_ac": "M0RCB1", "gene_name": "Hsc70-ps1", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "M0RCB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0RCB1" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "M0RCB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0RCB1" } ] } ] }, { "uniprot_ac": "P06761", "gene_name": "Hspa5", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P06761", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06761" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P06761", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06761" } ] } ] }, { "uniprot_ac": "P08289", "gene_name": "Alpl", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P08289", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08289" } ] }, { "ec_number": "3.9.1.1", "activity": "H2O + N-phosphocreatine = creatine + phosphate.", "evidence": [ { "id": "P08289", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08289" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "P08289", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08289" } ] } ] }, { "uniprot_ac": "P34158", "gene_name": "Cftr", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "P34158", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34158" } ] }, { "ec_number": "5.6.1.6", "activity": "", "evidence": [ { "id": "P34158", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34158" } ] } ] }, { "uniprot_ac": "P46462", "gene_name": "Vcp", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P46462", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46462" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "P46462", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46462" } ] } ] }, { "uniprot_ac": "P54777", "gene_name": "Pex6", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P54777", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54777" } ] } ] }, { "uniprot_ac": "P56536", "gene_name": "Kif5c", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P56536", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P56536" } ] } ] }, { "uniprot_ac": "P60123", "gene_name": "Ruvbl1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P60123", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60123" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P60123", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60123" } ] } ] }, { "uniprot_ac": "P60711", "gene_name": "Actb", 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