{
    "uniprot_canonical_ac": "A0A0G2JDV3-1",
    "uniprot_ac": "A0A0G2JDV3",
    "uniprot_id": "GBP6_MOUSE",
    "mass": {
        "chemical_mass": 70443.0,
        "monoisotopic_mass": 70443.0
    },
    "refseq": {},
    "gene_names": [
        {
            "name": "Gbp6",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A0A0G2JDV3",
            "id": "A0A0G2JDV3"
        },
        {
            "name": "Mpa2l",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A0G2JDV3",
            "id": "A0A0G2JDV3"
        }
    ],
    "protein_names": [
        {
            "name": "Guanylate-binding protein 6",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprotkb/A0A0G2JDV3/entry#names_and_taxonomy",
            "id": "A0A0G2JDV3"
        },
        {
            "name": "3.6.5.-",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprotkb/A0A0G2JDV3/entry#names_and_taxonomy",
            "id": "A0A0G2JDV3"
        },
        {
            "name": "GBP-6",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprotkb/A0A0G2JDV3/entry#names_and_taxonomy",
            "id": "A0A0G2JDV3"
        },
        {
            "name": "GTP-binding protein 6",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprotkb/A0A0G2JDV3/entry#names_and_taxonomy",
            "id": "A0A0G2JDV3"
        },
        {
            "name": "Guanine nucleotide-binding protein 6",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprotkb/A0A0G2JDV3/entry#names_and_taxonomy",
            "id": "A0A0G2JDV3"
        },
        {
            "name": "Macrophage activation 2 like protein",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprotkb/A0A0G2JDV3/entry#names_and_taxonomy",
            "id": "A0A0G2JDV3"
        }
    ],
    "function": [
        {
            "annotation": "Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens, such as bacterial pathogens Listeria monocytogenes and Mycobacterium bovis BCG as well as the protozoan pathogen Toxoplasma gondii (PubMed:18025219, PubMed:21551061). Confers protection to several pathogens, including the bacterial pathogens Listeria monocytogenes and Mycobacterium bovis BCG as well as the protozoan pathogen Toxoplasma gondii (PubMed:18025219, PubMed:21551061).",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A0G2JDV3",
                    "url": "https://www.uniprot.org/uniprot/A0A0G2JDV3#function"
                },
                {
                    "database": "PubMed",
                    "id": "18025219",
                    "url": "https://glygen.org/publication/PubMed/18025219"
                },
                {
                    "database": "PubMed",
                    "id": "21551061",
                    "url": "https://glygen.org/publication/PubMed/21551061"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A0G2JDV3",
                    "url": "https://www.uniprot.org/uniprot/A0A0G2JDV3"
                }
            ],
            "common_name": "Mouse",
            "glygen_name": "Mouse",
            "reference_species": "Mus musculus [10090]"
        }
    ],
    "gene": [
        {
            "name": "Gbp6",
            "url": "https://www.uniprot.org/uniprot/A0A0G2JDV3",
            "locus": {
                "chromosome": "5",
                "start_pos": 105418568,
                "end_pos": 105441564,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000104713",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000104713"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "A0A0G2JDV3",
            "url": "https://alphafold.ebi.ac.uk/entry/A0A0G2JDV3",
            "database": "AlphaFoldDB",
            "categories": []
        },
        {
            "id": "ENSMUSG00000104713",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000104713",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd01851",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01851",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "cd16269",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16269",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "100702",
            "url": "https://www.ncbi.nlm.nih.gov/gene/100702",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR003191",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR003191",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR015894",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR015894",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR027417",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR030386",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR030386",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR036543",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036543",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR037684",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR037684",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "mmu:100702",
            "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:100702",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "2140937",
            "url": "http://www.informatics.jax.org/marker/MGI:2140937",
            "database": "MGI",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "MECILAG",
            "url": "https://omabrowser.org/oma/group/MECILAG/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "QRTHREN",
            "url": "https://omabrowser.org/oma/group/QRTHREN/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "A0A0G2JDV3",
            "url": "https://www.orthodb.org/?gene=A0A0G2JDV3",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR10751",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10751",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR10751:SF126",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10751:SF126",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF02263",
            "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02263",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF02841",
            "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02841",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_A0A0G2JDV3",
            "url": "http://purl.obolibrary.org/obo/PR_A0A0G2JDV3",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "19669",
            "url": "https://www.rhea-db.org/rhea/19669",
            "database": "Rhea",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "A0A0G2JDV3",
            "url": "https://www.uniprot.org/uniprot/A0A0G2JDV3",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A0G2JDV3-1",
            "url": "https://www.uniprot.org/uniprot/A0A0G2JDV3-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A0G2JF24",
            "url": "https://www.uniprot.org/uniprot/A0A0G2JF24",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A0G2JF24-1",
            "url": "https://www.uniprot.org/uniprot/A0A0G2JF24-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8Q0QEH4",
            "url": "https://www.uniprot.org/uniprot/A0A8Q0QEH4",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8Q0QEH4-1",
            "url": "https://www.uniprot.org/uniprot/A0A8Q0QEH4-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MTQPQMAPICLVENHNEQLSVNQEAIEILDKISQPVVVVAIVGLYRTGKSYLMNCLAGQNHGFPLGSTVQSQTKGIWMWCMPHPTKPEHTLVLLDTEGLGDVEKGDPKNDLWIFALSVLLSSTFIYNSMITINHQALEQLQYVTELTELIRAKSSPNPAGIKNSTEFVSFFPDFVWTVRDFMLELKLNGEDITSDDYLENALKLIPGDKPRMQASNSCRECIRLFFPNRKCFVFDRPTHDKELLQKLDSITEDQLDPKFQEVTKAFVSYIFTYAKIKTLKEGIKVTGNRLGILVTTYVNAINSGAVPCLDDAVTTLAQRENSVAVQKAADHYSEQMAQRLRLPTETLQELLDVHAACEKEAMAVFMEHSFKDENQQFLKKLVELIGENKELFLSKNEEASNKYCQEELDRLSKDFMENISTFFVPCGHKLYMDKREKIEHDYWQVPRKGVKASEVFQSFLQSQAFIESSILQADTALTAGEKAIAEERAQKVAAEKEQELLRQKQKEQQEYMEAQEKSHKENLEQLRRKLEQEREQDIKDHDMMLKKLMKDQKAFLEEGFKKKAEEMNKEIQQLRDVIKDKKRNTDRIKEALLNGFSTVLFHYLVRYLKHL",
        "length": 611,
        "header": "sp|A0A0G2JDV3-1|GBP6_MOUSE Isoform 1 of Guanylate-binding protein 6  OS=Mus musculus OX=10090 GN=Gbp6 PE=2 SV=2 CANONICAL=A0A0G2JDV3-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A0G2JDV3-1",
            "url": "https://www.uniprot.org/uniprotkb/A0A0G2JDV3/entry#A0A0G2JDV3-1",
            "sequence": {
                "sequence": "MTQPQMAPICLVENHNEQLSVNQEAIEILDKISQPVVVVAIVGLYRTGKSYLMNCLAGQNHGFPLGSTVQSQTKGIWMWCMPHPTKPEHTLVLLDTEGLGDVEKGDPKNDLWIFALSVLLSSTFIYNSMITINHQALEQLQYVTELTELIRAKSSPNPAGIKNSTEFVSFFPDFVWTVRDFMLELKLNGEDITSDDYLENALKLIPGDKPRMQASNSCRECIRLFFPNRKCFVFDRPTHDKELLQKLDSITEDQLDPKFQEVTKAFVSYIFTYAKIKTLKEGIKVTGNRLGILVTTYVNAINSGAVPCLDDAVTTLAQRENSVAVQKAADHYSEQMAQRLRLPTETLQELLDVHAACEKEAMAVFMEHSFKDENQQFLKKLVELIGENKELFLSKNEEASNKYCQEELDRLSKDFMENISTFFVPCGHKLYMDKREKIEHDYWQVPRKGVKASEVFQSFLQSQAFIESSILQADTALTAGEKAIAEERAQKVAAEKEQELLRQKQKEQQEYMEAQEKSHKENLEQLRRKLEQEREQDIKDHDMMLKKLMKDQKAFLEEGFKKKAEEMNKEIQQLRDVIKDKKRNTDRIKEALLNGFSTVLFHYLVRYLKHL",
                "length": 611,
                "header": "sp|A0A0G2JDV3-1|GBP6_MOUSE Isoform 1 of Guanylate-binding protein 6  OS=Mus musculus OX=10090 GN=Gbp6 PE=2 SV=2 CANONICAL=A0A0G2JDV3-1"
            },
            "locus": {}
        },
        {
            "isoform_ac": "A0A0G2JF24-1",
            "url": "https://www.uniprot.org/uniprotkb/A0A0G2JDV3/entry#A0A0G2JF24-1",
            "sequence": {
                "sequence": "MTQPQMAPICLVENHNEQLSVNQEAIEILDKISQPVVVVAIVGLYRTGKSYLMNCLAGQNHG",
                "length": 62,
                "header": "tr|A0A0G2JF24-1|A0A0G2JF24_MOUSE Computationally mapped isoform of Guanylate binding protein 6  OS=Mus musculus OX=10090 GN=Gbp6 PE=3 SV=1 CANONICAL=A0A0G2JDV3-1"
            },
            "locus": {
                "chromosome": "5",
                "start_pos": 105438886,
                "end_pos": 105428429,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000200045.5",
                        "url": "https://www.ensembl.org/id/ENSMUST00000200045.5"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000142994.2",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000142994.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A0A8Q0QEH4-1",
            "url": "https://www.uniprot.org/uniprotkb/A0A0G2JDV3/entry#A0A8Q0QEH4-1",
            "sequence": {
                "sequence": "MTQPQMAPICLVENHNEQLSVNQEAIEILDKISQPVVVVAIVGLYRTGKSYLMNCLAGQNHGFPLGSTVQSQTKGIWMWCMPHPTKPEHTLVLLDTEGLGDVEKGDPKNDLWIFALSVLLSSTFIYNSMITINHQALEQLHYVTELTELIRAKSSPNPAGIKNSTEFVSFFPDFVWTVRDFMLELKLNGEDITSDDYLENALKLIPGDKPRMQASNSCRECIRLFFPNRKCFVFDRPTHDKELLQKLDSITEDQLDPKFQEVTKAFVSYIFTYAKIKTLKEGIKVTGNRLGILVTTYVNAINSGAVPCLDDAVTTLAQRENSVAVQKAADHYSEQMAQRLRLPTETLQELLDVHAACEKEAMAVFMEHSFKDENQQFLKKLVELIGENKELFLSKNEEASNKYCQEELDRLSKDFMENISTFFVPCGHKLYMDKREKIEHDYWQVPRKGVKASEVFQSFLQSQAFIESSILQADTALTAGEKAIAEERAQKVAAEKEQELLRQKQKEQQEYMEAQEKSHKENLEQLRRKLEQEREQDIKDHDMMLKKLMKDQKAFLEEGFKKKAEEMNKEIQQLRDVIKDKKRNTDRIKEALLNGFSTVLFHYLVRYLKHL",
                "length": 611,
                "header": "tr|A0A8Q0QEH4-1|A0A8Q0QEH4_MOUSE Computationally mapped isoform of Guanylate binding protein 6  OS=Mus musculus OX=10090 GN=Gbp6 PE=3 SV=1 CANONICAL=A0A0G2JDV3-1"
            },
            "locus": {
                "chromosome": "5",
                "start_pos": 105438886,
                "end_pos": 105420971,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000196520.2",
                        "url": "https://www.ensembl.org/id/ENSMUST00000196520.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000142518.2",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000142518.2"
                    }
                ]
            }
        }
    ],
    "glycosylation": [
        {
            "glytoucan_ac": "G49108TO",
            "type": "O-linked",
            "subtype": "O-GlcNAcylation",
            "prediction_tool": "",
            "mining_tool": "",
            "site_category": "reported_with_glycan",
            "site_category_dict": {
                "reported_with_glycan": true
            },
            "site_seq": "",
            "relation": "attached",
            "comment": "O-GlcNAcylation",
            "evidence": [
                {
                    "id": "37507081",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/37507081"
                },
                {
                    "id": "A0A0G2JDV3",
                    "database": "O-GlcNAc Database",
                    "url": "https://www.oglcnac.mcw.edu/search/?query_protein=A0A0G2JDV3"
                }
            ],
            "filter_code": "00000000000000000000.0000000.00000001000000.1000000.0100000000.10010000111101.00000.01000"
        }
    ],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [
        "enzyme",
        "glycoprotein",
        "glycoprotein_reported_with_glycan"
    ],
    "publication": [
        {
            "title": "Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10 involved in host defense.",
            "journal": "Journal of immunology (Baltimore, Md. : 1950)",
            "date": "2007",
            "authors": "Degrandi D, Konermann C, Beuter-Gunia C, Kresse A, Wurthner J, Kurig S, Beer S, Pfeffer K",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A0G2JDV3",
                    "url": "https://www.uniprot.org/uniprot/A0A0G2JDV3"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "18025219",
                    "url": "https://glygen.org/publication/PubMed/18025219"
                }
            ]
        },
        {
            "title": "A family of IFN-gamma-inducible 65-kD GTPases protects against bacterial infection.",
            "journal": "Science (New York, N.Y.)",
            "date": "2011",
            "authors": "Kim BH, Shenoy AR, Kumar P, Das R, Tiwari S, MacMicking JD",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A0G2JDV3",
                    "url": "https://www.uniprot.org/uniprot/A0A0G2JDV3"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "21551061",
                    "url": "https://glygen.org/publication/PubMed/21551061"
                }
            ]
        },
        {
            "title": "Differential Detection of O-GlcNAcylated proteins in the heart using antibodies.",
            "journal": "Analytical biochemistry",
            "date": "2023-10-01",
            "authors": "Narayanan Bhargavi, Zahra Fiddia, Reeves Russell A, Aggarwal Akanksha, O'Meally Robert N, Henry Roger K, Craven Megan, Jacobson Avital, Cole Robert N, Kohr Mark J, Umapathi Priya, Zachara Natasha E",
            "evidence": [
                {
                    "database": "O-GlcNAc Database",
                    "id": "A0A0G2JDV3",
                    "url": "https://www.oglcnac.mcw.edu/search/?query_protein=A0A0G2JDV3"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "37507081",
                    "url": "https://glygen.org/publication/PubMed/37507081"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "mmu:100702",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:100702",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "A0A8I6A3C3-1",
            "protein_name": "Guanylate binding protein family member 6",
            "gene_name": "Gbp6",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MAPICLVENHNERLSVNQKAIEILDKISQPVVVVAIVGLYRTGKSYLMNCLAGQNHGFPLGSTVQSQTKGIWMWCVPHPTKPKHTLVLLDTEGLGDVEKGDPKNDSWIFALAVLLSSTFVYNSLSTINHQALEQLYYVTELTKLIRARSSPNPDGIKNSTEFVSFFPDFVWTVRDFMLELTLNGKNITSDEYLENALKLIPGNSPRIQASNLPRECIRQFFPNRKCFVFDRPTHDKELLQKLETISEDQLDPNFREGTKAFVSYIFTYAKMKTLREGIKVTGNRLGTLVTTYVDAINSGAVPCLDDAVTTLAQRENSVAVQKAVDHYSEQMAQRLRLPTDTLQELLDEHTACEKEAISVFMEHSFKDENQLFLKKLVKLIGEKKGLFVLKNEEASDKYCQEELDRLSKDFMENISTFSVPGGHRLYVDMREKIERDYWQVPRKGVKASEVFQSFLQSQVIIESSILQADTALTAGEKAIAEERTQREAAEKEQELLRQKQREQQQLMEAQEKSNKENLEQLREKLVQERKQLIEEHNMMLEKQLKVGLLIPLVVLVPQVVGEGWRPGHGETP",
                "length": 572
            },
            "evidence": [
                {
                    "id": "A0A0G2JDV3",
                    "url": "https://omabrowser.org/oma/group/A0A0G2JDV3/",
                    "database": "OMA"
                }
            ],
            "glygen_name": "Rat",
            "common_name": "Rat"
        },
        {
            "uniprot_canonical_ac": "Q6ZN66-1",
            "protein_name": "Guanylate-binding protein 6",
            "gene_name": "GBP6",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MESGPKMLAPVCLVENNNEQLLVNQQAIQILEKISQPVVVVAIVGLYRTGKSYLMNHLAGQNHGFPLGSTVQSETKGIWMWCVPHPSKPNHTLVLLDTEGLGDVEKGDPKNDSWIFALAVLLCSTFVYNSMSTINHQALEQLHYVTELTELIKAKSSPRPDGVEDSTEFVSFFPDFLWTVRDFTLELKLNGHPITEDEYLENALKLIQGNNPRVQTSNFPRECIRRFFPKRKCFVFDRPTNDKDLLANIEKVSEKQLDPKFQEQTNIFCSYIFTHARTKTLREGITVTGNRLGTLAVTYVEAINSGAVPCLENAVITLAQRENSAAVQRAADYYSQQMAQRVKLPTDTLQELLDMHAACEREAIAIFMEHSFKDENQEFQKKFMETTMNKKGDFLLQNEESSVQYCQAKLNELSKGLMESISAGSFSVPGGHKLYMETKERIEQDYWQVPRKGVKAKEVFQRFLESQMVIEESILQSDKALTDREKAVAVDRAKKEAAEKEQELLKQKLQEQQQQMEAQDKSRKENIAQLKEKLQMEREHLLREQIMMLEHTQKVQNDWLHEGFKKKYEEMNAEISQFKRMIDTTKNDDTPWIARTLDNLADELTAILSAPAKLIGHGVKGVSSLFKKHKLPF",
                "length": 633
            },
            "evidence": [
                {
                    "id": "47562225",
                    "url": "http://www.informatics.jax.org/homology/47562225",
                    "database": "MGI"
                }
            ],
            "glygen_name": "Human",
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Molecular Function",
                "total": 2,
                "go_terms": [
                    {
                        "name": "GTPase activity",
                        "id": "GO:0003924",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JDV3",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JDV3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "GTP binding",
                        "id": "GO:0005525",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JDV3",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JDV3"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 7,
                "go_terms": [
                    {
                        "name": "cellular response to type II interferon",
                        "id": "GO:0071346",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071346",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JDV3",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JDV3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "adhesion of symbiont to host",
                        "id": "GO:0044406",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044406",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JDV3",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JDV3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "defense response to Gram-positive bacterium",
                        "id": "GO:0050830",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050830",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JDV3",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JDV3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "response to bacterium",
                        "id": "GO:0009617",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009617",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JDV3",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JDV3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cellular response to lipopolysaccharide",
                        "id": "GO:0071222",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071222",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JDV3",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JDV3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cellular response to interferon-beta",
                        "id": "GO:0035458",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035458",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JDV3",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JDV3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "defense response to protozoan",
                        "id": "GO:0042832",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042832",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JDV3",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JDV3"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 2,
                "go_terms": [
                    {
                        "name": "cytoplasmic vesicle",
                        "id": "GO:0031410",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031410",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JDV3",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JDV3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "symbiont-containing vacuole membrane",
                        "id": "GO:0020005",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0020005",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JDV3",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JDV3"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 163,
            "end_pos": 165,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 418,
            "end_pos": 420,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [
        {
            "id": "19669",
            "name": "",
            "equation": "GTP + H2O = GDP + H(+) + phosphate",
            "summary": "",
            "cellular_location": "",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P61021-1",
                "Q62293-1",
                "Q61107-1",
                "P60766-2",
                "Q8BZ98-1",
                "Q8CFB4-1",
                "Q8C3X4-1",
                "P32233-1",
                "Q9Z0E6-1",
                "Q9QXB9-1",
                "Q01514-1",
                "Q8K1M6-12",
                "P39053-1",
                "P39054-1",
                "Q8C262-1",
                "Q8C7H1-1",
                "Q5S006-1",
                "Q80U63-1",
                "Q811U4-1",
                "Q9QZ85-1",
                "Q05D44-1",
                "P58281-1",
                "Q99P58-1",
                "Q9QUI0-1",
                "Q9ERI2-1",
                "P63001-1",
                "Q9CQD1-1",
                "Q3T9E4-1",
                "Q7TQD2-1",
                "P56371-1",
                "P62821-1",
                "P62492-1",
                "Q91ZR1-1",
                "P35278-1",
                "P46638-1",
                "P51150-1",
                "Q3TCT4-1",
                "Q9CQW2-1",
                "Q9D1G1-1",
                "P61226-1",
                "P61027-1",
                "P62071-1",
                "Q99JI6-1",
                "Q8R367-1",
                "Q922H7-1",
                "Q8BU31-1",
                "Q80ZJ1-1",
                "Q80X95-1",
                "O08989-1",
                "P70426-1",
                "Q8K5A4-1",
                "P10833-1",
                "P70425-1",
                "Q61411-1",
                "Q5SSG5-1",
                "Q7TT45-1",
                "Q6NTA4-1",
                "Q99K70-1",
                "Q9JIW9-1",
                "Q08AT1-1",
                "P60764-1",
                "P62835-1",
                "P63321-1",
                "Q6IMB1-1",
                "P32883-1",
                "Q9Z0N2-1",
                "Q9Z0N1-1",
                "P08556-1",
                "Q7TN89-1",
                "A4UUI3-1",
                "Q8VEH6-1",
                "A0A0G2JDV3-1",
                "P68368-1",
                "Q91Z40-1",
                "P62331-1",
                "Q60766-1",
                "A0A140LIF8-1",
                "Q9DCE9-1",
                "Q3UX10-1",
                "Q9JJZ2-1",
                "Q0GUM3-1",
                "E9PXC0-1",
                "P53994-1",
                "P59279-1",
                "P62827-1",
                "P68369-1",
                "P55258-1",
                "P61294-1",
                "Q61820-1",
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                "P05213-1",
                "P68373-1",
                "P84078-1",
                "Q9CQA9-1",
                "Q69ZS7-1",
                "Q921J2-1",
                "Q149F3-1",
                "Q8R050-1",
                "P14576-1",
                "P55772-1",
                "Q8R2Q4-1",
                "B2RVE2-1",
                "P10126-1",
                "Q9JHW4-1",
                "P61222-1",
                "P58252-1",
                "Q5PR73-1",
                "Q91V41-1",
                "P36536-1",
                "Q9CQC9-1"
            ],
            "evidence": [
                {
                    "id": "19669",
                    "database": "Rhea",
                    "url": "https://www.rhea-db.org/rhea/19669"
                }
            ]
        }
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                {
                    "ec_number": "3.6.5.-",
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                            "id": "A0A0G2JDV3",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/A0A0G2JDV3"
                        }
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                            "id": "A0A140LIF8",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/A0A140LIF8"
                        }
                    ]
                }
            ]
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        {
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                    "activity": "",
                    "evidence": [
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                            "id": "A4UUI3",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/A4UUI3"
                        }
                    ]
                }
            ]
        },
        {
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                    "activity": "GTP + H2O = GDP + H(+) + phosphate.",
                    "evidence": [
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                            "id": "B2RVE2",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/B2RVE2"
                        }
                    ]
                },
                {
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                    "activity": "",
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                            "id": "B2RVE2",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/B2RVE2"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "E9PXC0",
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                {
                    "ec_number": "3.6.5.-",
                    "activity": "",
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                            "id": "E9PXC0",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/E9PXC0"
                        }
                    ]
                }
            ]
        },
        {
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                    "activity": "GTP + H2O = GDP + H(+) + phosphate.",
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                            "id": "O08989",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/O08989"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.5.2",
                    "activity": "",
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                        {
                            "id": "O08989",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/O08989"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P05213",
            "gene_name": "Tuba1b",
            "activity": [
                {
                    "ec_number": "3.6.5.-",
                    "activity": "",
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                            "id": "P05213",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P05213"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P05214",
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                {
                    "ec_number": "3.6.5.-",
                    "activity": "",
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                            "id": "P05214",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P05214"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P08556",
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                    "ec_number": "3.6.5.2",
                    "activity": "GTP + H2O = GDP + H(+) + phosphate.",
                    "evidence": [
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                            "id": "P08556",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P08556"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.5.2",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P08556",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P08556"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P10126",
            "gene_name": "Eef1a1",
            "activity": [
                {
                    "ec_number": "3.6.5.-",
                    "activity": "",
                    "evidence": [
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                            "id": "P10126",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P10126"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P10833",
            "gene_name": "Rras",
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                {
                    "ec_number": "3.6.5.-",
                    "activity": "",
                    "evidence": [
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                            "id": "P10833",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P10833"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P14576",
            "gene_name": "Srp54",
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                    "ec_number": "3.6.5.4",
                    "activity": "GTP + H2O = GDP + H(+) + phosphate.",
                    "evidence": [
                        {
                            "id": "P14576",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P14576"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.5.4",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P14576",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P14576"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P32233",
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                    "ec_number": "3.6.5.-",
                    "activity": "",
                    "evidence": [
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                            "id": "P32233",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P32233"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P32883",
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                    "activity": "GTP + H2O = GDP + H(+) + phosphate.",
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                            "id": "P32883",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P32883"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.5.2",
                    "activity": "",
                    "evidence": [
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                            "id": "P32883",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P32883"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P35278",
            "gene_name": "Rab5c",
            "activity": [
                {
                    "ec_number": "3.6.5.2",
                    "activity": "GTP + H2O = GDP + H(+) + phosphate.",
                    "evidence": [
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                            "id": "P35278",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P35278"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.5.2",
                    "activity": "",
                    "evidence": [
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                            "id": "P35278",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P35278"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P36536",
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                    "ec_number": "3.6.5.2",
                    "activity": "GTP + H2O = GDP + H(+) + phosphate.",
                    "evidence": [
                        {
                            "id": "P36536",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P36536"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.5.2",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P36536",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P36536"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P39053",
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                    "ec_number": "3.6.5.5",
                    "activity": "GTP + H2O = GDP + H(+) + phosphate.",
                    "evidence": [
                        {
                            "id": "P39053",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P39053"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.5.5",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P39053",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P39053"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P39054",
            "gene_name": "Dnm2",
            "activity": [
                {
                    "ec_number": "3.6.5.5",
                    "activity": "GTP + H2O = GDP + H(+) + phosphate.",
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                        {
                            "id": "P39054",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P39054"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.5.5",
                    "activity": "",
                    "evidence": [
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                            "id": "P39054",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P39054"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P46638",
            "gene_name": "Rab11b",
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                {
                    "ec_number": "3.6.5.2",
                    "activity": "GTP + H2O = GDP + H(+) + phosphate.",
                    "evidence": [
                        {
                            "id": "P46638",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P46638"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.5.2",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P46638",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P46638"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P51150",
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                {
                    "ec_number": "3.6.5.2",
                    "activity": "GTP + H2O = GDP + H(+) + phosphate.",
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                            "id": "P51150",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P51150"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.5.2",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P51150",
                            "database": "UniProtKB",
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