{ "uniprot_canonical_ac": "A0A0B4LF36-1", "uniprot_ac": "A0A0B4LF36", "uniprot_id": "A0A0B4LF36_DROME", "mass": { "chemical_mass": 8357.0, "monoisotopic_mass": 8357.0 }, "refseq": { "ac": "NP_001286270", "name": "cytochrome c oxidase subunit 7C-like", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001286270" }, "gene_names": [ { "name": "COX7CL", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A0B4LF36", "id": "A0A0B4LF36" }, { "name": "CG44296; Dmel\\CG44296", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001286270", "id": "NP_001286270" }, { "name": "CG44296", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A0B4LF36", "id": "A0A0B4LF36" }, { "name": "COX7CL", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001286270", "id": "NP_001286270" }, { "name": "Dmel\\CG44296", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A0B4LF36", "id": "A0A0B4LF36" }, { "name": "Dmel_CG44296", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A0B4LF36", "id": "A0A0B4LF36" } ], "protein_names": [ { "name": "CG44296-PA; COX7CL-PA", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001286270", "id": "NP_001286270" }, { "name": "Uncharacterized protein", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0B4LF36/entry#names_and_taxonomy", "id": "A0A0B4LF36" }, { "name": "cytochrome c oxidase subunit 7C-like", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001286270", "id": "NP_001286270" } ], "function": [], "disease": [ { "disease_id": "DOID:10652", "recommended_name": { "id": "DOID:10652", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10652", "name": "Alzheimer's disease", "description": "A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid." }, "synonyms": [ { "id": "DOID:10652", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10652", "name": "Alzheimer disease", "description": "" }, { "id": "DOID:10652", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10652", "name": "Alzheimers dementia", "description": "" } ], "evidence": [ { "id": "10652", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10652" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "A0A0B4LF36", "url": "https://www.uniprot.org/uniprot/A0A0B4LF36" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "gene": [ { "name": "COX7CL", "url": "https://www.uniprot.org/uniprot/A0A0B4LF36", "locus": { "chromosome": "2R", "start_pos": 10050874, "end_pos": 10050348, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "FBgn0265342", "url": "https://www.ensemblgenomes.org/id/FBgn0265342" } ] } } ], "crossref": [ { "id": "A0A0B4LF36", "url": "https://alphafold.ebi.ac.uk/entry/A0A0B4LF36", "database": "AlphaFoldDB", "categories": [] }, { "id": "FBgn0265342", "url": "https://bgee.org/?page=gene&gene_id=FBgn0265342", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "FBgn0265342", "url": "https://flybase.org/reports/FBgn0265342", "database": "FlyBase", "categories": [ "Organism-specific" ] }, { "id": "19835750", "url": "https://www.ncbi.nlm.nih.gov/gene/19835750", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004202", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004202", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036636", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036636", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "dme:Dmel_CG44296", "url": "https://www.genome.jp/dbget-bin/www_bget?dme:Dmel_CG44296", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RSCHHGY", "url": "https://omabrowser.org/oma/group/RSCHHGY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A0B4LF36", "url": "https://www.orthodb.org/?gene=A0A0B4LF36", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13313", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13313", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13313:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13313:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02935", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02935", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "NP_001286270", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001286270", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A0B4LF36", "url": "https://www.uniprot.org/uniprot/A0A0B4LF36", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0B4LF36-1", "url": "https://www.uniprot.org/uniprot/A0A0B4LF36-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MWPTLRKPIGKFSGPLMRYGSGYPGGSPGANLPFGLDSPMRFTLFYLIAGVVGFGAPFLVIRHQMLRNVTNDPKDE", "length": 76, "header": "tr|A0A0B4LF36-1|A0A0B4LF36_DROME Isoform 1 of Uncharacterized protein OS=Drosophila melanogaster OX=7227 GN=COX7CL PE=3 SV=1 CANONICAL=A0A0B4LF36-1" }, "isoforms": [ { "isoform_ac": "A0A0B4LF36-1", "url": "https://www.uniprot.org/uniprotkb/A0A0B4LF36/entry#A0A0B4LF36-1", "sequence": { "sequence": "MWPTLRKPIGKFSGPLMRYGSGYPGGSPGANLPFGLDSPMRFTLFYLIAGVVGFGAPFLVIRHQMLRNVTNDPKDE", "length": 76, "header": "tr|A0A0B4LF36-1|A0A0B4LF36_DROME Isoform 1 of Uncharacterized protein OS=Drosophila melanogaster OX=7227 GN=COX7CL PE=3 SV=1 CANONICAL=A0A0B4LF36-1" }, "locus": { "chromosome": "2R", "start_pos": 10050815, "end_pos": 10050471, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0339413", "url": "https://www.ensemblgenomes.org/id/FBtr0339413" }, { "database": "Ensembl Peptide", "id": "FBpp0308503", "url": "https://www.ensemblgenomes.org/id/FBpp0308503" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "The genome sequence of Drosophila melanogaster.", "journal": "Science", "date": "2000", "authors": "Adams MD, Celniker SE, Holt RA, Evans CA, Gocayne JD, Amanatides PG, Scherer SE, Li PW, Hoskins RA, Galle RF, George RA, Lewis SE, Richards S, Ashburner M, Henderson SN, Sutton GG, Wortman JR, Yandell MD, Zhang Q, Chen LX, Brandon RC, Rogers YH, Blazej RG, Champe M, Pfeiffer BD, Wan KH, Doyle C, Baxter EG, Helt G, Nelson CR, Gabor GL, Abril JF, Agbayani A, An HJ, Andrews-Pfannkoch C, Baldwin D, Ballew RM, Basu A, Baxendale J, Bayraktaroglu L, Beasley EM, Beeson KY, Benos PV, Berman BP, Bhandari D, Bolshakov S, Borkova D, Botchan MR, Bouck J, Brokstein P, Brottier P, Burtis KC, Busam DA, Butler H, Cadieu E, Center A, Chandra I, Cherry JM, Cawley S, Dahlke C, Davenport LB, Davies P, de Pablos B, Delcher A, Deng Z, Mays AD, Dew I, Dietz SM, Dodson K, Doup LE, Downes M, Dugan-Rocha S, Dunkov BC, Dunn P, Durbin KJ, Evangelista CC, Ferraz C, Ferriera S, Fleischmann W, Fosler C, Gabrielian AE, Garg NS, Gelbart WM, Glasser K, Glodek A, Gong F, Gorrell JH, Gu Z, Guan P, Harris M, Harris NL, Harvey D, Heiman TJ, Hernandez JR, Houck J, Hostin D, Houston KA, Howland TJ, Wei MH, Ibegwam C, Jalali M, Kalush F, Karpen GH, Ke Z, Kennison JA, Ketchum KA, Kimmel BE, Kodira CD, Kraft C, Kravitz S, Kulp D, Lai Z, Lasko P, Lei Y, Levitsky AA, Li J, Li Z, Liang Y, Lin X, Liu X, Mattei B, McIntosh TC, McLeod MP, McPherson D, Merkulov G, Milshina NV, Mobarry C, Morris J, Moshrefi A, Mount SM, Moy M, Murphy B, Murphy L, Muzny DM, Nelson DL, Nelson DR, Nelson KA, Nixon K, Nusskern DR, Pacleb JM, Palazzolo M, Pittman GS, Pan S, Pollard J, Puri V, Reese MG, Reinert K, Remington K, Saunders RD, Scheeler F, Shen H, Shue BC, Siden-Kiamos I, Simpson M, Skupski MP, Smith T, Spier E, Spradling AC, Stapleton M, Strong R, Sun E, Svirskas R, Tector C, Turner R, Venter E, Wang AH, Wang X, Wang ZY, Wassarman DA, Weinstock GM, Weissenbach J, Williams SM, WoodageT, Worley KC, Wu D, Yang S, Yao QA, Ye J, Yeh RF, Zaveri JS, Zhan M, Zhang G, Zhao Q, Zheng L, Zheng XH, Zhong FN, Zhong W, Zhou X, Zhu S, Zhu X, Smith HO, Gibbs RA, Myers EW, Rubin GM, Venter JC", "evidence": [ { "database": "UniProtKB", "id": "A0A0B4LF36", "url": "https://www.uniprot.org/uniprot/A0A0B4LF36" } ], "reference": [ { "type": "PubMed", "id": "10731132", "url": "https://glygen.org/publication/PubMed/10731132" } ] }, { "title": "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence.", "journal": "Genome Biol.", "date": "2002", "authors": "Celniker SE, Wheeler DA, Kronmiller B, Carlson JW, Halpern A, Patel S, Adams M, Champe M, Dugan SP, Frise E, Hodgson A, George RA, Hoskins RA, Laverty T, Muzny DM, Nelson CR, Pacleb JM, Park S, Pfeiffer BD, Richards S, Sodergren EJ, Svirskas R, Tabor PE, Wan K, Stapleton M, Sutton GG, Venter C, Weinstock G, Scherer SE, Myers EW, Gibbs RA, Rubin GM", "evidence": [ { "database": "UniProtKB", "id": "A0A0B4LF36", "url": "https://www.uniprot.org/uniprot/A0A0B4LF36" } ], "reference": [ { "type": "PubMed", "id": "12537568", "url": "https://glygen.org/publication/PubMed/12537568" } ] }, { "title": "Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.", "journal": "Genome Biol.", "date": "2002", "authors": "Misra S, Crosby MA, Mungall CJ, Matthews BB, Campbell KS, Hradecky P, Huang Y, Kaminker JS, Millburn GH, Prochnik SE, Smith CD, Tupy JL, Whitfied EJ, Bayraktaroglu L, Berman BP, Bettencourt BR, Celniker SE, de Grey AD, Drysdale RA, Harris NL, Richter J, Russo S, Schroeder AJ, Shu SQ, Stapleton M, Yamada C, Ashburner M, Gelbart WM, Rubin GM, Lewis SE", "evidence": [ { "database": "UniProtKB", "id": "A0A0B4LF36", "url": "https://www.uniprot.org/uniprot/A0A0B4LF36" } ], "reference": [ { "type": "PubMed", "id": "12537572", "url": "https://glygen.org/publication/PubMed/12537572" } ] }, { "title": "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective.", "journal": "Genome Biol.", "date": "2002", "authors": "Kaminker JS, Bergman CM, Kronmiller B, Carlson J, Svirskas R, Patel S, Frise E, Wheeler DA, Lewis SE, Rubin GM, Ashburner M, Celniker SE", "evidence": [ { "database": "UniProtKB", "id": "A0A0B4LF36", "url": "https://www.uniprot.org/uniprot/A0A0B4LF36" } ], "reference": [ { "type": "PubMed", "id": "12537573", "url": "https://glygen.org/publication/PubMed/12537573" } ] }, { "title": "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.", "journal": "Genome Biol.", "date": "2002", "authors": "Hoskins RA, Smith CD, Carlson JW, Carvalho AB, Halpern A, Kaminker JS, Kennedy C, Mungall CJ, Sullivan BA, Sutton GG, Yasuhara JC, Wakimoto BT, Myers EW, Celniker SE, Rubin GM, Karpen GH", "evidence": [ { "database": "UniProtKB", "id": "A0A0B4LF36", "url": "https://www.uniprot.org/uniprot/A0A0B4LF36" } ], "reference": [ { "type": "PubMed", "id": "12537574", "url": "https://glygen.org/publication/PubMed/12537574" } ] }, { "title": "Combined evidence annotation of transposable elements in genome sequences.", "journal": "PLoS Comput. Biol.", "date": "2005", "authors": "Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D", "evidence": [ { "database": "UniProtKB", "id": "A0A0B4LF36", "url": "https://www.uniprot.org/uniprot/A0A0B4LF36" } ], "reference": [ { "type": "PubMed", "id": "16110336", "url": "https://glygen.org/publication/PubMed/16110336" } ] }, { "title": "The Release 5.1 annotation of Drosophila melanogaster heterochromatin.", "journal": "Science", "date": "2007", "authors": "Smith CD, Shu S, Mungall CJ, Karpen GH", "evidence": [ { "database": "UniProtKB", "id": "A0A0B4LF36", "url": "https://www.uniprot.org/uniprot/A0A0B4LF36" } ], "reference": [ { "type": "PubMed", "id": "17569856", "url": "https://glygen.org/publication/PubMed/17569856" } ] }, { "title": "Sequence finishing and mapping of Drosophila melanogaster heterochromatin.", "journal": "Science", "date": "2007", "authors": "Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE", "evidence": [ { "database": "UniProtKB", "id": "A0A0B4LF36", "url": "https://www.uniprot.org/uniprot/A0A0B4LF36" } ], "reference": [ { "type": "PubMed", "id": "17569867", "url": "https://glygen.org/publication/PubMed/17569867" } ] } ], "pathway": [ { "id": "dme:Dmel_CG44296", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?dme:Dmel_CG44296", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "mitochondrial electron transport, cytochrome c to oxygen", "id": "GO:0006123", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006123", "evidence": [ { "database": "UniProtKB", "id": "A0A0B4LF36", "url": "https://www.uniprot.org/uniprot/A0A0B4LF36" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrial respiratory chain complex IV", "id": "GO:0005751", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005751", "evidence": [ { "database": "UniProtKB", "id": "A0A0B4LF36", "url": "https://www.uniprot.org/uniprot/A0A0B4LF36" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 68, "end_pos": 70, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A0B4LF36-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 76, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A0B4LF36-F1.pdb" } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 68, "end_pos": 70 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 8 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }