The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A0B4KGS4-1", "Q9VI13-1", "Q9VXH3-1" ], "evidence": [ { "id": "R-DME-2730856", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-2730856" } ] }, { "id": "R-DME-2730889", "name": "Recruitment of PAK to the membrane by binding active RAC1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A0B4KGS4-1", "Q9VI13-1", "Q9VXH3-1" ], "evidence": [ { "id": "R-DME-2730889", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-2730889" } ] }, { "id": "R-DME-389788", "name": "Activation of PAKs by RAC1 and CDC42", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P40793-1", "A0A0B4KGS4-1", "Q9VI13-1" ], "evidence": [ { "id": "R-DME-389788", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-389788" } ] }, { "id": "R-DME-3928625", "name": "PAKs autophosphorylate", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P00528-1", "A0A0B4KGS4-1", "Q9V4E5-1", "Q9VI13-1" ], "evidence": [ { "id": "R-DME-3928625", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-3928625" } ] }, { "id": "R-DME-3928640", "name": "PAKs phosphorylate MLC", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [ "R-DME-390735" ], "output_participant_list": [ "R-DME-390749" ], "enzyme_list": [ "P00528-1", "A0A0B4KGS4-1", "Q9V4E5-1", "Q9VI13-1" ], "evidence": [ { "id": "R-DME-3928640", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-3928640" } ] }, { "id": "R-DME-3928641", "name": "PAK binds RAC and bPIX", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P00528-1", "A0A0B4KGS4-1", "Q9V4E5-1", "Q9VI13-1" ], "evidence": [ { "id": "R-DME-3928641", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-3928641" } ] }, { "id": "R-DME-399930", "name": "Activation of PAK by Rac1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P00528-1", "P18106-4", "A0A0B4KGS4-1", "Q9VI13-1" ], "evidence": [ { "id": "R-DME-399930", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-399930" } ] }, { "id": "R-DME-399939", "name": "Autophosphorylation of PAK", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P00528-1", "P18106-4", "A0A0B4KGS4-1", "Q9VI13-1" ], "evidence": [ { "id": "R-DME-399939", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-399939" } ] }, { "id": "R-DME-399952", "name": "Phosphorylation of LIMK-1 by PAK", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [ "R-DME-397785" ], "output_participant_list": [ "R-DME-399816" ], "enzyme_list": [ "P00528-1", "P18106-4", "Q8IR79-1", "A0A0B4KGS4-1", "Q9VI13-1" ], "evidence": [ { "id": "R-DME-399952", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-399952" } ] }, { "id": "R-DME-430183", "name": "NCK binds PAK", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A0B4KGS4-1", "Q9VI13-1" ], "evidence": [ { "id": "R-DME-430183", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-430183" } ] }, { "id": "R-DME-5218804", "name": "p38 MAPK activation by VEGFR", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1JHB7-1", "O62618-1", "P00528-1", "P40793-1", "P83100-1", "A0A0B4KGS4-1", "O61443-1", "Q9VI13-1" ], "evidence": [ { "id": "R-DME-5218804", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-5218804" } ] }, { "id": "R-DME-5218812", "name": "FYN phosphorylates PAK2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1JHB7-1", "P00528-1", "P40793-1", "A0A0B4KGS4-1", "Q9VI13-1" ], "evidence": [ { "id": "R-DME-5218812", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-5218812" } ] }, { "id": "R-DME-5218814", "name": "PAK2 autophorylates", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1JHB7-1", "P00528-1", "P40793-1", "A0A0B4KGS4-1", "Q9VI13-1" ], "evidence": [ { "id": "R-DME-5218814", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-5218814" } ] }, { "id": "R-DME-5218832", "name": "CDC42:GTP binds PAK2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1JHB7-1", "P00528-1", "P40793-1", "A0A0B4KGS4-1", "Q9VI13-1" ], "evidence": [ { "id": "R-DME-5218832", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-5218832" } ] }, { "id": "R-DME-5218847", "name": "PAK2 binds NCK", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1JHB7-1", "P00528-1", "A0A0B4KGS4-1", "Q9VI13-1" ], "evidence": [ { "id": "R-DME-5218847", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-5218847" } ] }, { "id": "R-DME-5357445", "name": "PAK1-3 dimer disassociates", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A0B4KGS4-1", "Q9VI13-1" ], "evidence": [ { "id": "R-DME-5357445", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-5357445" } ] }, { "id": "R-DME-5357472", "name": "PAK1-3 autophosphorylates", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A0B4KGS4-1", "Q9VI13-1" ], "evidence": [ { "id": "R-DME-5357472", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-5357472" } ] }, { "id": "R-DME-5357477", "name": "PAK1-3 phosphorylates VE-cadherin", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A0B4KGS4-1", "Q9VI13-1" ], "evidence": [ { "id": "R-DME-5357477", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-5357477" } ] }, { "id": "R-DME-5357483", "name": "RAC1 binds PAK1-3", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A0B4KGS4-1", "Q9VI13-1" ], "evidence": [ { "id": "R-DME-5357483", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-5357483" } ] }, { "id": "R-DME-5624492", "name": "PAK phosphorylates p21 RAF1 on S338", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P11346-1", "P08646-1", "A0A0B4KGS4-1", "Q9VI13-1" ], "evidence": [ { "id": "R-DME-5624492", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-5624492" } ] }, { "id": "R-DME-5627775", "name": "Autophosphorylation of PAK1,2,3", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P40793-1", "A0A0B4KGS4-1", "Q9VI13-1" ], "evidence": [ { "id": "R-DME-5627775", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-5627775" } ] }, { "id": "R-DME-5668932", "name": "PAK2 phosphorylates myosin regulatory light chain (MRLC)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A0B4KGS4-1", "Q9VI13-1" ], "evidence": [ { "id": "R-DME-5668932", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-5668932" } ] }, { "id": "R-DME-8981926", "name": "RAC1 and CDC42 activate PAK3", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P40793-1", "A0A0B4KGS4-1", "Q9VI13-1" ], "evidence": [ { "id": "R-DME-8981926", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-8981926" } ] }, { "id": "R-DME-8981931", "name": "RAC1 and CDC42 activate PAK2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P40793-1", "A0A0B4KGS4-1", "Q9VI13-1" ], "evidence": [ { "id": "R-DME-8981931", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-8981931" } ] }, { "id": "R-DME-9013145", "name": "RAC1 binds effectors at the plasma membrane", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P00522-1", "P40793-1", "Q9VXE5-1", "Q9W1B0-1", "B7YZT5-1", "M9PI41-1", "A0A0B4KGS4-1", "Q9V4E5-1", "A1Z7T0-1", "Q9VI13-1", "O76742-1" ], "evidence": [ { "id": "R-DME-9013145", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-9013145" } ] }, { "id": "R-DME-9014294", "name": "RAC2 binds effectors at the plasma membrane", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P40793-1", "Q9VXE5-1", "B7YZT5-1", "A0A0B4KGS4-1", "Q9V4E5-1", "Q9VI13-1", "O76742-1" ], "evidence": [ { "id": "R-DME-9014294", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-9014294" } ] }, { "id": "R-DME-9014449", "name": "RHOG binds effectors at the plasma membrane", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9VZU4-1", "P40793-1", "Q95UN8-1", "Q9VXE5-1", "B7YZT5-1", "A0A0B4KGS4-1", "Q9V4E5-1", "Q9VI13-1", "O76742-1" ], "evidence": [ { "id": "R-DME-9014449", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-9014449" } ] }, { "id": "R-DME-9018746", "name": "RHOQ binds effectors at the plasma membrane", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P40793-1", "Q9VXE5-1", "Q9Y0H4-1", "Q9W1B0-1", "A0A0B4KGS4-1", "Q9VI13-1", "O76742-1" ], "evidence": [ { "id": "R-DME-9018746", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-9018746" } ] }, { "id": "R-DME-9018758", "name": "RHOH binds effectors at the plasma membrane", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9VXY3-1", "P00528-1", "Q7KN62-1", "Q9VXE5-1", "Q9VXE3-1", "A0A0B4KGS4-1", "Q9VI13-1", "O76742-1", "Q8INJ8-1" ], "evidence": [ { "id": "R-DME-9018758", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-9018758" } ] }, { "id": "R-DME-9018766", "name": "RHOU binds effectors at the plasma membrane", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P40793-1", "Q9VXE5-1", "Q9Y0H4-1", "P55824-1", "A0A0B4KGS4-1", "Q9V4E5-1", "Q9VI13-1", "Q9VRP3-1" ], "evidence": [ { "id": "R-DME-9018766", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-9018766" } ] }, { "id": "R-DME-9018794", "name": "RHOV binds effectors at the plasma membrane", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q7K4D1-1", "P40793-1", "Q95UN8-1", "Q9VXE5-1", "P55824-1", "A0A0B4KGS4-1", "Q9V4E5-1", "Q9VI13-1", "Q9VRP3-1" ], "evidence": [ { "id": "R-DME-9018794", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-9018794" } ] }, { "id": "R-DME-9018808", "name": "RAC3 binds effectors at the plasma membrane", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P00522-1", "P40793-1", "Q9VXE5-1", "A0A0B4KGS4-1", "Q9V4E5-1", "Q9VI13-1", "O76742-1" ], "evidence": [ { "id": "R-DME-9018808", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-9018808" } ] } ], "reaction_participants": [ { "participant_id": "R-DME-390735", "participant_name": "MYL12A [cytosol]", "crossref": [ { "id": "NP_001284929.1", "database": "RefSeq", "url": "" }, { "id": "FBgn0003514", "database": "Flybase", "url": "" }, { "id": "NP_511057.1", "database": "RefSeq", "url": "" }, { "id": "NP_001284931.1", "database": "RefSeq", "url": "" }, { "id": "P40423", "database": "UniProt", "url": "" }, { "id": "NP_001284928.1", "database": "RefSeq", "url": "" }, { "id": "NP_001284930.1", "database": "RefSeq", "url": "" }, { "id": "P40423", "database": "PRO", "url": "" } ] }, { "participant_id": "R-DME-390749", "participant_name": "phospho-p-S19-MYL12A [cytosol]", "crossref": [ { "id": "P40423", "database": "UniProt", "url": "" }, { "id": "NP_001284929.1", "database": "RefSeq", "url": "" }, { "id": "P40423", "database": "PRO", "url": "" }, { "id": "NP_001284931.1", "database": "RefSeq", "url": "" }, { "id": "NP_001284928.1", "database": "RefSeq", "url": "" }, { "id": "FBgn0003514", "database": "Flybase", "url": "" }, { "id": "NP_001284930.1", "database": "RefSeq", "url": "" }, { "id": "NP_511057.1", "database": "RefSeq", "url": "" } ] }, { "participant_id": "R-DME-397785", "participant_name": "LIMK1 [cytosol]", "crossref": [ { "id": "NP_001162733.1", "database": "RefSeq", "url": "" }, { "id": "FBgn0283712", "database": "Flybase", "url": "" }, { "id": "NP_727621.1", "database": "RefSeq", "url": "" }, { "id": "Q8IR79", "database": "UniProt", "url": "" }, { "id": "Q8IR79", "database": "PRO", "url": "" }, { "id": "NP_511139.2", "database": "RefSeq", "url": "" }, { "id": "NP_727622.1", "database": "RefSeq", "url": "" } ] }, { "participant_id": "R-DME-399816", "participant_name": "phospho-p-T508-LIMK1 [cytosol]", "crossref": [ { "id": "Q8IR79", "database": "UniProt", "url": "" }, { "id": "Q8IR79", "database": "PRO", "url": "" }, { "id": "FBgn0283712", "database": "Flybase", "url": "" }, { "id": "NP_727622.1", "database": "RefSeq", "url": "" }, { "id": "NP_727621.1", "database": "RefSeq", "url": "" }, { "id": "NP_511139.2", "database": "RefSeq", "url": "" }, { "id": "NP_001162733.1", "database": "RefSeq", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A0B4KGS4", "gene_name": "Pak3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A0B4KGS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0B4KGS4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A0B4KGS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0B4KGS4" } ] } ] }, { "uniprot_ac": "A1Z7T0", "gene_name": "Pkn", "activity": [ { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A1Z7T0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A1Z7T0" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A1Z7T0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A1Z7T0" } ] }, { "ec_number": "2.7.11.-", "activity": "", "evidence": [ { "id": "A1Z7T0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A1Z7T0" } ] } ] }, { "uniprot_ac": "B7YZT5", "gene_name": "Pld", "activity": [ { "ec_number": "3.1.4.4", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphate + choline + H(+).", "evidence": [ { "id": "B7YZT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B7YZT5" } ] }, { "ec_number": "3.1.4.4", "activity": "", "evidence": [ { "id": "B7YZT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B7YZT5" } ] } ] }, { "uniprot_ac": "E1JHB7", "gene_name": "Pvr", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "E1JHB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E1JHB7" } ] } ] }, { "uniprot_ac": "M9PI41", "gene_name": "sti", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "M9PI41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M9PI41" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "M9PI41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M9PI41" } ] } ] }, { "uniprot_ac": "O61443", "gene_name": "p38b", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O61443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O61443" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "O61443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O61443" } ] } ] }, { "uniprot_ac": "O62618", "gene_name": "p38a", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O62618", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O62618" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "O62618", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O62618" } ] }, { "ec_number": "2.7.11.-", "activity": "", "evidence": [ { "id": "O62618", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O62618" } ] } ] }, { "uniprot_ac": "O76742", "gene_name": "Rab7", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "O76742", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O76742" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "O76742", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O76742" } ] } ] }, { "uniprot_ac": "P00522", "gene_name": "Abl", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P00522", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00522" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P00522", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00522" } ] } ] }, { "uniprot_ac": "P00528", "gene_name": "Src64B", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P00528", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00528" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P00528", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00528" } ] } ] }, { "uniprot_ac": "P08646", "gene_name": "Ras85D", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P08646", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08646" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P08646", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08646" } ] } ] }, { "uniprot_ac": "P11346", "gene_name": "Raf", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P11346", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11346" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P11346", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11346" } ] } ] }, { "uniprot_ac": "P18106", "gene_name": "FER", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P18106", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18106" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P18106", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18106" } ] } ] }, { "uniprot_ac": "P40793", "gene_name": "Cdc42", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P40793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40793" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P40793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40793" } ] } ] }, { "uniprot_ac": "P55824", "gene_name": "faf", "activity": [ { "ec_number": "3.4.19.12", "activity": "Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).", "evidence": [ { "id": "P55824", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P55824" } ] }, { "ec_number": "3.4.19.12", "activity": "", "evidence": [ { "id": "P55824", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P55824" } ] } ] }, { "uniprot_ac": "P83100", "gene_name": "p38c", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P83100", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P83100" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P83100", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P83100" } ] } ] }, { "uniprot_ac": "Q7K4D1", "gene_name": "POSH", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q7K4D1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7K4D1" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q7K4D1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7K4D1" } ] } ] }, { "uniprot_ac": "Q7KN62", "gene_name": "TER94", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "Q7KN62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7KN62" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "Q7KN62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7KN62" } ] } ] }, { "uniprot_ac": "Q8INJ8", "gene_name": "Csk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q8INJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8INJ8" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q8INJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8INJ8" } ] } ] }, { "uniprot_ac": "Q8IR79", "gene_name": "LIMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8IR79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8IR79" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q8IR79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8IR79" } ] } ] }, { "uniprot_ac": "Q95UN8", "gene_name": "slpr", "activity": [ { "ec_number": "2.7.11.25", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q95UN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q95UN8" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "Q95UN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q95UN8" } ] } ] }, { "uniprot_ac": "Q9V4E5", "gene_name": "Eph", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q9V4E5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9V4E5" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q9V4E5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9V4E5" } ] } ] }, { "uniprot_ac": "Q9VI13", "gene_name": "Pak", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9VI13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VI13" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9VI13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VI13" } ] } ] }, { "uniprot_ac": "Q9VRP3", "gene_name": "Txl", "activity": [ { "ec_number": "1.8.1.9", "activity": "[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + H(+) + NADPH.", "evidence": [ { "id": "Q9VRP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VRP3" } ] } ] }, { "uniprot_ac": "Q9VXE3", "gene_name": "Rok", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9VXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VXE3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9VXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VXE3" } ] } ] }, { "uniprot_ac": "Q9VXE5", "gene_name": "mbt", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + 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