{ "uniprot_canonical_ac": "A0A0B4KFD1-1", "uniprot_ac": "A0A0B4KFD1", "uniprot_id": "A0A0B4KFD1_DROME", "mass": { "chemical_mass": 530554.0, "monoisotopic_mass": 530554.0 }, "refseq": { "ac": "NP_001260800", "name": "LDL receptor protein 1, isoform F", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001260800" }, "gene_names": [ { "name": "LRP1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A0B4KFD1", "id": "A0A0B4KFD1" }, { "name": "CG30368; CG33087; CG8706; CT9297; Dm CG33087; Dmel\\CG33087; dmLRP1; LRP-1; lrp1; Lrp1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001260800", "id": "NP_001260800" }, { "name": "CG30368", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A0B4KFD1", "id": "A0A0B4KFD1" }, { "name": "CG33087", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A0B4KFD1", "id": "A0A0B4KFD1" }, { "name": "CG8706", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A0B4KFD1", "id": "A0A0B4KFD1" }, { "name": "CT9297", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A0B4KFD1", "id": "A0A0B4KFD1" }, { "name": "Dm CG33087", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A0B4KFD1", "id": "A0A0B4KFD1" }, { "name": "Dmel\\CG33087", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A0B4KFD1", "id": "A0A0B4KFD1" }, { "name": "Dmel_CG33087", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A0B4KFD1", "id": "A0A0B4KFD1" }, { "name": "LDLR", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A0B4KFD1", "id": "A0A0B4KFD1" }, { "name": "LRP1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001260800", "id": "NP_001260800" }, { "name": "Lrp1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A0B4KFD1", "id": "A0A0B4KFD1" }, { "name": "lrp1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A0B4KFD1", "id": "A0A0B4KFD1" } ], "protein_names": [ { "name": "CG33087-PF; LRP1-PF; LDL-receptor-related protein 1; LDL receptor-related protein 1; LDL receptor protein", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001260800", "id": "NP_001260800" }, { "name": "LDL receptor protein 1, isoform F", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001260800", "id": "NP_001260800" }, { "name": "LDL receptor protein 1, isoform F", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0B4KFD1/entry#names_and_taxonomy", "id": "A0A0B4KFD1" } ], "function": [], "disease": [ { "disease_id": "DOID:0050700", "recommended_name": { "id": "DOID:0050700", 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"MONDO:0008124", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008124", "name": "type - epigastric - defect in the cephalic fold", "description": "" }, { "id": "MONDO:0008124", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008124", "name": "type - hypogastric - defect in the caudal fold", "description": "" } ], "evidence": [ { "id": "0060327", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0060327" } ] }, { "disease_id": "DOID:0080751", "recommended_name": { "id": "DOID:0080751", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080751", "name": "keratosis pilaris atrophicans", "description": "An ichthyosis that is characterized by perifollicular keratosis and inflammation that progresses to atrophy and scarring of the facial skin." }, "synonyms": [ { "id": "MONDO:0018855", "resource": "MONDO", "url": 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"https://monarchinitiative.org/disease/MONDO:0018855", "name": "KPA", "description": "" }, { "id": "MONDO:0018855", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018855", "name": "amelogenesis imperfecta, hypoplastic-hypomaturation, X-linked 2", "description": "" }, { "id": "MONDO:0018855", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018855", "name": "burnett Schwartz Berberian syndrome", "description": "" }, { "id": "MONDO:0018855", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018855", "name": "folliculitis ulerythematosa", "description": "" }, { "id": "MONDO:0018855", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018855", "name": "folliculitis ulerythematosa reticulata", "description": "" }, { "id": "MONDO:0018855", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018855", "name": "honeycomb atrophy", "description": "" }, { "id": "MONDO:0018855", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018855", "name": "keratosis pilaris", "description": "" }, { "id": "MONDO:0018855", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018855", "name": "keratosis pilaris atrophicans facies", "description": "" }, { "id": "MONDO:0018855", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018855", "name": "ulerythema ophryogenes", "description": "" }, { "id": "MONDO:0018855", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018855", "name": "ulerythema ophryogenes with multiple congenital anomalies", "description": "" }, { "id": "MONDO:0018855", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018855", "name": "ulerythema ophryogenesis", "description": "" }, { "id": "MIM:604093", "resource": "MIM", "url": "https://www.omim.org/entry/604093", "name": "Keratosis pilaris atrophicans", "description": "Keratosis pilaris 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"MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ], "evidence": [ { "id": "10534", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10534" } ] }, { "disease_id": "DOID:10652", "recommended_name": { "id": "DOID:10652", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10652", "name": "Alzheimer's disease", "description": "A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid." }, "synonyms": [ { "id": "DOID:10652", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10652", "name": "Alzheimer disease", "description": "" }, { "id": "DOID:10652", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10652", "name": "Alzheimers dementia", "description": "" } ], "evidence": [ { "id": "10652", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10652" } ] }, { "disease_id": "DOID:11044", "recommended_name": { "id": "DOID:11044", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11044", "name": "gastroschisis", "description": "" }, "synonyms": [ { "id": "MONDO:0009264", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009264", "name": "gastroschisis", "description": "Gastroschisis is marked by viscera protruding, without a covering sac, from the fetal abdomen on the right lateral base of the umbilicus. 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"description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "adenocarcinoma of lung, susceptibility 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"id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "cancer of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, resistance to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung neoplasm", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumor", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumour", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "Nonsmall cell lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "alveolar cell carcinoma", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung neoplasm", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ], "evidence": [ { "id": "1324", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1324" } ] }, { "disease_id": "DOID:1826", "recommended_name": { "id": "DOID:1826", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1826", "name": "epilepsy", "description": "A brain disease that is characterized by the occurrance of at least two unprovoked seizures resulting from a persistent epileptogenic abnormality of the brain that is able to spontaneously generate paroxysmal activity and typically manifested by sudden brief episodes of altered or diminished consciousness, involuntary movements, or convulsions." }, "synonyms": [ { "id": "DOID:1826", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1826", "name": "epilepsy syndrome", "description": "" }, { "id": "DOID:1826", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1826", "name": "epileptic syndrome", "description": "" } ], "evidence": [ { "id": "1826", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1826" } ] }, { "disease_id": "DOID:1909", "recommended_name": { "id": "DOID:1909", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1909", "name": "melanoma", "description": "A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from melanocytes which are found in skin, the bowel and the eye." }, "synonyms": [ { "id": "DOID:1909", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1909", "name": "Naevocarcinoma", "description": "" }, { "id": "DOID:1909", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1909", "name": "malignant melanoma", "description": "" } ], "evidence": [ { "id": "1909", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1909" } ] }, { "disease_id": "DOID:219", "recommended_name": { "id": "DOID:219", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:219", "name": "colon cancer", "description": "A colorectal cancer that is located_in the colon." }, "synonyms": [], "evidence": [ { "id": "219", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:219" } ] }, { "disease_id": "DOID:3083", "recommended_name": { "id": "DOID:3083", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3083", "name": "chronic obstructive pulmonary disease", "description": "An obstructive lung disease that is a chronic and progressive disorder of small airways in the lungs and that is characterized by irreversible airflow obstruction, typically identified by reductions in quantitative spirometric indices, induced forced expiratory volume at 1 second (FEV1) and the ratio of FEV1 to forced vital capacity (less than 0.7 is diagnostic of COPD). Lung volume is increased and pulmonary hypertension may occur. The pathologic changes result in the disruption of the airflow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough and chest tightness. COPD is a consequence (an end result) of chronic bronchitis, emphysema or both." }, "synonyms": [ { "id": "DOID:3083", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3083", "name": "COLD", "description": "" }, { "id": "DOID:3083", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3083", "name": "COPD", "description": "" }, { "id": "DOID:3083", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3083", "name": "chronic obstructive airway disease", "description": "" }, { "id": "DOID:3083", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3083", "name": "chronic obstructive lung disease", "description": "" }, { "id": "MONDO:0005002", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005002", "name": "chronic obstructive pulmonary disease", "description": "A chronic and progressive lung disorder characterized by the loss of elasticity of the bronchial tree and the air sacs, destruction of the air sacs wall, thickening of the bronchial wall, and mucous accumulation in the bronchial tree. The pathologic changes result in the disruption of the air flow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough, and chest tightness. The two main types of chronic obstructive pulmonary disease are chronic obstructive bronchitis and emphysema." }, { "id": "MONDO:0005002", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005002", "name": "COPD", "description": "" }, { "id": "MONDO:0005002", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005002", "name": "COPD, chronic obstructive pulmonary disease", "description": "" }, { "id": "MONDO:0005002", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005002", "name": "chronic obstructive airway disease", "description": "" }, { "id": "MONDO:0005002", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005002", "name": "chronic obstructive airways disease", "description": "" }, { "id": "MONDO:0005002", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005002", "name": "chronic obstructive lung disease", "description": "" }, { "id": "MONDO:0005002", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005002", "name": "chronic obstructive pulmonary disease (COPD)", "description": "" }, { "id": "MONDO:0005002", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005002", "name": "chronic obstructive pulmonary disease, (COPD)", "description": "" }, { "id": "MONDO:0005002", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005002", "name": "cold", "description": "" }, { "id": "MONDO:0005002", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005002", "name": "cold (chronic obstructive lung disease)", "description": "" }, { "id": "MONDO:0005002", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005002", "name": "disease (COPD), chronic obstructive", "description": "" }, { "id": "MONDO:0005002", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005002", "name": "obstructive lung disease, chronic", "description": "" }, { "id": "MONDO:0005002", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005002", "name": "obstructive pulmonary disease (COPD), chronic", "description": "" }, { "id": "MONDO:0005002", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005002", "name": "pulmonary disease (COPD), chronic obstructive", "description": "" } ], "evidence": [ { "id": "3083", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:3083" } ] }, { "disease_id": "DOID:3121", "recommended_name": { "id": "DOID:3121", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3121", "name": "gallbladder cancer", "description": "A biliary tract cancer that is located_in the gallbladder." }, "synonyms": [ { "id": "DOID:3121", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3121", "name": "gallbladder Ca", "description": "" }, { "id": "DOID:3121", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3121", "name": "gallbladder neoplasm", "description": "" }, { "id": "DOID:3121", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3121", "name": "localized malignant gallbladder neoplasm", "description": "" }, { "id": "DOID:3121", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3121", "name": "malignant neoplasm of gallbladder", "description": "" }, { "id": "DOID:3121", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3121", "name": "malignant tumor of the gallbladder", "description": "" }, { "id": "DOID:3121", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3121", "name": "malignant tumour of gallbladder", "description": "" }, { "id": "DOID:3121", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3121", "name": "tumor of the gallbladder", "description": "" } ], "evidence": [ { "id": "3121", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:3121" } ] }, { "disease_id": "DOID:3827", "recommended_name": { "id": "DOID:3827", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3827", "name": "congenital diaphragmatic hernia", "description": "A diaphragm disease characterized by the lack of development of all or part of the diaphragm, which results in an abnormal opening that allows the stomach and intestines to move into the chest cavity and crowd the heart and lungs." }, "synonyms": [ { "id": "DOID:3827", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3827", "name": "Diaphragmatic Hernia", "description": "" }, { "id": "MONDO:0007719", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007719", "name": "diaphragmatic hernia 1", "description": "" }, { "id": "MONDO:0007719", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007719", "name": "diaphragmatic hernia, congenital 1", "description": "" }, { "id": "MONDO:0007719", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007719", "name": "hernia, congenital diaphragmatic 1", "description": "" }, { "id": "MONDO:0007719", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007719", "name": "DIH1", "description": "" }, { "id": "MONDO:0007719", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007719", "name": "diaphragm, complete agenesis of", "description": "" }, { "id": "MONDO:0007719", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007719", "name": "diaphragm, unilateral agenesis of", "description": "" }, { "id": "MONDO:0007719", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007719", "name": "diaphragmatic defect, congenital", "description": "" }, { "id": "MONDO:0007719", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007719", "name": "diaphragmatic hernia, congenital", "description": "" }, { "id": "MONDO:0007719", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007719", "name": "hemidiaphragm, agenesis of", "description": "" }, { "id": "MONDO:0007719", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007719", "name": "hernia, congenital diaphragmatic", "description": "" }, { "id": "MONDO:0009103", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009103", "name": "diaphragmatic hernia 2", "description": "" }, { "id": "MONDO:0009103", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009103", "name": "diaphragmatic hernia 2", "description": "" }, { "id": "MONDO:0009103", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009103", "name": "hernia, congenital diaphragmatic 2", "description": "" }, { "id": "MONDO:0009103", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009103", "name": "DIH2", "description": "" }, { "id": "MONDO:0012431", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012431", "name": "diaphragmatic hernia 3", "description": "Any congenital diaphragmatic hernia in which the cause of the disease is a mutation in the ZFPM2 gene." }, { "id": "MONDO:0012431", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012431", "name": "ZFPM2 congenital diaphragmatic hernia", "description": "" }, { "id": "MONDO:0012431", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012431", "name": "congenital diaphragmatic hernia caused by mutation in ZFPM2", "description": "" }, { "id": "MONDO:0012431", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012431", "name": "diaphragmatic hernia 3", "description": "" }, { "id": "MONDO:0012431", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012431", "name": "diaphragmatic hernia type 3", "description": "" }, { "id": "MONDO:0012431", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012431", "name": "DIH3", "description": "" }, { "id": "MIM:610187", "resource": "MIM", "url": "https://www.omim.org/entry/610187", "name": "Diaphragmatic hernia 3", "description": "Diaphragmatic hernia 3" } ], "evidence": [ { "id": "3827", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:3827" } ] }, { "disease_id": "DOID:3908", "recommended_name": { "id": "DOID:3908", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3908", "name": "lung non-small cell carcinoma", "description": "A lung carcinoma that is characterized as any type of epithelial lung cancer other than small cell lung carcinoma." }, "synonyms": [ { "id": "DOID:3908", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3908", "name": "NSCLC", "description": "" }, { "id": "DOID:3908", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3908", "name": "Non-small cell lung cancer", "description": "" }, { "id": "DOID:3908", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3908", "name": "non-small cell lung carcinoma", "description": "" } ], "evidence": [ { "id": "3908", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:3908" } ] }, { "disease_id": "DOID:3910", "recommended_name": { "id": "DOID:3910", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3910", "name": "lung adenocarcinoma", "description": "A lung non-small cell carcinoma that derives_from epithelial cells of glandular origin." }, "synonyms": [ { "id": "DOID:3910", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3910", "name": "bronchogenic lung adenocarcinoma", "description": "" }, { "id": "DOID:3910", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3910", "name": "nonsmall cell adenocarcinoma", "description": "" } ], "evidence": [ { "id": "3910", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:3910" } ] }, { "disease_id": "DOID:4928", "recommended_name": { "id": "DOID:4928", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4928", "name": "intrahepatic cholangiocarcinoma", "description": "A cholangiocarcinoma that arises from the intrahepatic bile duct epithelium in any site of the intrahepatic biliary tree." }, "synonyms": [ { "id": "DOID:4928", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4928", "name": "Intrahepatic bile duct carcinoma", "description": "" }, { "id": "DOID:4928", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4928", "name": "peripheral Cholangiocarcinoma", "description": "" } ], "evidence": [ { "id": "4928", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:4928" } ] }, { "disease_id": "DOID:5844", "recommended_name": { "id": "DOID:5844", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5844", "name": "myocardial infarction", "description": "A coronary artery disease characterized by myocardial cell death (myocardial necrosis) due to prolonged ischaemia." }, "synonyms": [ { "id": "DOID:5844", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5844", "name": "Myocardial infarct", "description": "" }, { "id": "DOID:5844", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5844", "name": "heart attack", "description": "" }, { "id": "MONDO:0012058", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012058", "name": "myocardial infarction, susceptibility to, 2", "description": "" }, { "id": "MONDO:0012058", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012058", "name": "myocardial infarction, susceptibility to, 2", "description": "" }, { "id": "MONDO:0012058", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012058", "name": "myocardial infarction, susceptibility to, type 2", "description": "" }, { "id": "MONDO:0012058", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012058", "name": "Mci2", "description": "" } ], "evidence": [ { "id": "5844", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:5844" } ] }, { "disease_id": "DOID:684", "recommended_name": { "id": "DOID:684", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:684", "name": "hepatocellular carcinoma", "description": "A liver carcinoma that has_material_basis_in undifferentiated hepatocytes and located_in the liver." }, "synonyms": [ { "id": "DOID:684", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:684", "name": "Hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma", "description": "A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, there is a wide range of differentiation from tumor to tumor (well differentiated to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize to regional lymph nodes and lung. The overall median survival of untreated liver cell carcinoma is about 4 months. The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation." }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "HCC", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "cancer, hepatocellular", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of liver", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of the liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma, hepatocellular, malignant", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular adenocarcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular cancer", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular cancer, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma, childhood type, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cell cancer (hepatocellular carcinoma)", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cell carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "primary carcinoma of liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "primary carcinoma of the liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "adult hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "adult primary hepatocellular carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma caused by somatic mutation", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver and intrahepatic bile duct carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cancer", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma", "description": "A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, there is a wide range of differentiation from tumor to tumor (well differentiated to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize to regional lymph nodes and lung. The overall median survival of untreated liver cell carcinoma is about 4 months. The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation." }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "HCC", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "cancer, hepatocellular", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of liver", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of the liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma, hepatocellular, malignant", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular adenocarcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular cancer", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular cancer, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma, childhood type, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cell cancer (hepatocellular carcinoma)", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cell carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "primary carcinoma of liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "primary carcinoma of the liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "adult hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "adult primary hepatocellular carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma caused by somatic mutation", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver and intrahepatic bile duct carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cancer", "description": "" }, { "id": "MIM:114550", "resource": "MIM", "url": "https://www.omim.org/entry/114550", "name": "Hepatocellular carcinoma", "description": "Hepatocellular carcinoma" } ], "evidence": [ { "id": "684", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:684" } ] }, { "disease_id": "DOID:8634", "recommended_name": { "id": "DOID:8634", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8634", "name": "prostate carcinoma in situ", "description": "An in situ carcinoma that is located_in the prostate." }, "synonyms": [ { "id": "DOID:8634", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8634", "name": "PIN III", "description": "" }, { "id": "DOID:8634", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8634", "name": "carcinoma in situ of prostate", "description": "" }, { "id": "DOID:8634", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8634", "name": "grade III PIN", "description": "" } ], "evidence": [ { "id": "8634", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:8634" } ] }, { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant 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"expression_disease": [], "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "A0A0B4KFD1", "url": "https://www.uniprot.org/uniprot/A0A0B4KFD1" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "gene": [ { "name": "LRP1", "url": "https://www.uniprot.org/uniprot/A0A0B4KFD1", "locus": { "chromosome": "2R", "start_pos": 8226438, "end_pos": 8174165, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "FBgn0053087", "url": "https://www.ensemblgenomes.org/id/FBgn0053087" } ] } } ], "crossref": [ { "id": "FBgn0053087", "url": "https://bgee.org/?page=gene&gene_id=FBgn0053087", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00054", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00054", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd00112", "url": 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"url": "https://www.ebi.ac.uk/interpro/entry/IPR001881", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002172", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002172", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009030", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009030", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011042", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011042", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018097", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018097", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023415", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023415", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036055", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036055", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049883", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049883", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051221", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051221", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "dme:Dmel_CG33087", "url": "https://www.genome.jp/dbget-bin/www_bget?dme:Dmel_CG33087", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PSRNPCT", "url": "https://omabrowser.org/oma/group/PSRNPCT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A0B4KFD1", "url": "https://www.orthodb.org/?gene=A0A0B4KFD1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A1Z7C4", "url": "https://www.orthodb.org/?gene=A1Z7C4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22722", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22722", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22722:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22722:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00008", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00008", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00057", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00057", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00058", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00058", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF07645", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07645", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_A1Z7C4", "url": "http://purl.obolibrary.org/obo/PR_A1Z7C4", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_001260800", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001260800", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A0B4KFD1", "url": "https://www.uniprot.org/uniprot/A0A0B4KFD1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0B4KFD1-1", "url": "https://www.uniprot.org/uniprot/A0A0B4KFD1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A1Z7C4", "url": "https://www.uniprot.org/uniprot/A1Z7C4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A1Z7C4-1", "url": "https://www.uniprot.org/uniprot/A1Z7C4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPATANSWILLLLLLVAVERCSSNSSGRINSRSSSSGYRKVQWQEQQEAPTLRPLPDKGNAHKSRNRIKPTVFIRPNAALTAGGGPCPASYFTCNDGFCIPMRWKCDSKADCPDMSDEGSECAPKCNEGQFRCGVSRHCIPNNWLCDGEFDCGKGDISDELNCPNGDTPKCRAFEGQCRNGDCLELSRFCDGRWDCDNDELQCDKQNAACAALNCSFNCKLTPQGARCYCPKDQVPESSNSTRCVDYDECSEPGTCDQVCRNTPGSYECSCVSGYAKTKGNRCRAINVPPTEPTTLIFLSRDGVQSVGTNGTEVIGPPGAKDNDKVTDKDGVGSEEELLLSQPLRFVHAFEVWHRNRTLCSLLFSWPELQMRCQRVDDARVNWTLPFSSFVSPQQFFTELRLDWLSGNWYLVSEDDGLVYLCTNAMTYCRVILQQVDPLSSLDLDPTKGFMFYTDWTPSLSRSLLDGSNRTVLVTDQVYHPSSVTLDLANELVYWIDIYKDEVNRVDYEGRNRWTLKRPLDSPVPLKTIHAVEVFENSIYLAAWMDTAIVALDKFSLKTHILQSNVSRGANLRIFHRQKQPEVAHPCRDNNAGCNQICVPQWTKGFASAKCMCTAGYKLHNQTTCLLSALDKFLVYSDKHLARISGIPLDTEQVQQLEQIGEQPDVMVPVYNVSKTLAIDVNVRGKAVFYVVADSGASPFGNGEPSCSIRSQSLNGSVSRLLAQGLKRVHAVAFDWINDHLYWTSHKKMQVAPLRNLSKVLTFNTDCDAMSLELDPTTGLLYWSQWESQSCEAGIYSSWMDGTHKELLAKGTSSMPMQWPRSLDVDRRTKELYWCDIRLSTIELMRLDGTGREVLFKSDQFHPYSIVQNNGLIYWADNKNSTILRFHAHQANLSSTFSSTVHLQRTGRAADLRIFDIASQPLPQTPSACAQSKCPGMCLNTPKGAICRCPDGFTLNGTGSHCIPQLAPSPIRPNCTSGYMCRSTRQCLDTKDMCDGFEDCEDGIDESSDPKGPCNVNTCDKTHNFVCNGRCYQRSLLCSTIPYCSDGTDQANCHQNTCNSNEFTCHKSGRCIQLTWVNDGVVDCGPDDDSDETSETIFASKCPEFDCNNGRCRQFADVCDGIDNCGNNADEMECEQECEHGEKYCRPIGCYGEMHMCDGIHDCLDFSDEANCNQTKSDNHPVTEWKELGECAPLEFACMFPFECIPDFLRCDGISHCFDKTDEFNCTHINTTRFDMNETVICEHPDRLCGFSKQCVTVDQLCDGKNDCEDTTDEGFLCADKLCDRGHECSHRCHNTPEGYICSCPDHLYLQPNGKRCSMQHACDHWDTCSQVCESSGKGYDCRCLDGFDLGFDRFTCKSTAPDEPYVIFTNRQDIKGINLKTLNVGNFYSSLRNIIALDFLYNNESNVEIYWTDVIDDKIYRGHLVGESLRNVEAVIHSGLSTTEGLAVDWVGKNLYWIDSNLDQIEVAKLNGSFRRTLIAGNMESPRAIALDPREGLLFWTDWDDNSPRIERASMSGDGRRMISTSWQLSAGWPNGLTLDYTQKRVYWVDAKSDSISSTMYDGSEHHVVLRNKEILSHPFAISVFENYVYWTDWRTTSVIRANKWNGSDVQVLQRTQSQPFGIQVLHSSRQPWDRNPCGENNGGCSHLCLLSGRGTFKCECPHVMRLDPANERNCVPNEQVLLFVMVDEIRGIDLHQPNHHTIPTIRQSPRLVAPQRIDFLVDESRIFWSDIQQNEISSAGISNGLIEPIINTNIEKPYGFAVDWIARNMYFSSGQIKCNILASNLKGEFASIIHEDLNMVDSIVLDPANGKMYWIHSASDGSMSQLEQSNLDGSSRSLIYQHENNLQSLTMDFDSQRLYYAYDNSGIAYYDIPRNETRKVLVASPITSISSLTVYNGTLYFPENIQSVIMQCEKEACSNMSYLRVNTKSIQSMKMFYADAQTGSNTCAEWAYRGGCQQLCLATSSIDHVCRCALGYDVEPNNPTGCVPRAEFIFYSIDVLQGVEMIDPSEQFDTPSPALVPISRVSSASFIDYLANTDTLYWGDNELGSISRVKRDGTQRETILEALNLVGYKQQDWLGGIAIDWVAGNIYWSDTKRNIIEVARLDGSHRYVVVSNLEKPTALAVDPLQGLLFYVTQQHIGRVGLDGSQPFVLVNQTRANWAVGSLVLDIEATKVYWCERYPDALMKVDYDGNLREQLLNESLNNPVALAKMGDYLYWAENKYNEGIIRVAPLANLSQSKVVLQTEQDAIRDLKIYSKHLQRGSNPCAHSNGACEQLCLFNGTSAVCACAHSRLASDGYSCEPYENFLLFSYRSNIESIHMTDHADKNWPVQMISNTSLMRNVIAITYNYEEQLVYYSDVQLSTINQVHFNGTGHRVLLEQQQRVEGLAYDIVNEQLFWTSNNNATIRSVELRHLSEHADQNQVHVKKVLSLREDDKPRGIAVEPCLGMIYWTNWNEGSPCIQRSYLTGYGTEVIIKTDIKMPNALTLDLEQQKLYWADARLDKIERTNYDGSNRVVLAHSTPKHAFAMAVYGDLLFWTDWVLHAVVRANKYTGTDVLFLREHVTRPMGIVAVQNTSINCDANQCKILNGQCEDVCILNKSGQATCHCTQGVLAPDGRRCIAPVNTSCGLSQYNCHSGECIPLELTCDNVTHCADGSDEFRSYCIFRQCPETHFMCQNHRCIPKEHKCDGEQQCGDGSDETPLLCKCQSEDIDMHPSNNNTKEMPDMFRCGSGECIPRKFLCDSLKDCRDFSDEKMCAPIPCEKNDMTFVHCGNSTICIMPRWRCDGDPDCPDGTDELDCANHTSLSCDPGQFRCASGNCIAGSWHCDGEKDCPDGSDEINCRTECRHNQFACDKTCIPASWQCDGKSDCEDGSDEGPQCPNRPCRPHLFQCKSSGRCIPQKWVCDGEKDCPSGLGDEGSEDEGPQCGGVAHIPDCPPPAHLCTSGLCIDSHYVCDGDEDCPGGDDEYEGCVPAFQPHSCPGGSLMHQCQDGLCIFKNQTCDGKPDCGDGSDETSSLCAHTRGCNGTDDFRCKNGACIHADLLCDRRNDCADFSDEELCNVNECLIPDICEHECEDKVVGYQCHCRPGYKVLPKSPHLCTDIDECDEQQPCSQTCINTYGSYKCLCAKGYALVDHHTCKATSNVSMELIFSNRYYIRQVDMTGNGSILINELSNAVALDYDWDSQCLYWSDVTSTVGTIKRYCPKENKTQTLHQAMLKNPDGLAVDWVAKNLYWCDKGLDTIEVSQLDGKYRKVLINEYLREPRGIALHPYQQHIFWSDWGDSPHIGKAGMDGSNPKMIIRDGLGWPNALTISFETQQLFWGDAREDTISVSDLDGNHTRLLLARSINPLLNLHHIFAIAVWEGHIYWSDWETKSIEYCSIFNGQNCTTLITTIHRPMDLRVFHPYRQQQPMSGNPCLAANCSTLCVLSPEEPYYKCMCPTNFILADDGRTCRANCTAAHFECVNTYKCIPFYWRCDTQDDCGDGSDEPETCPPFHCEPGQYQCANKKCTHPSNLCDGINQCGDGSDELNCDKFTCFDNHMKCGATANSSAFCVDNVKRCDGVKDCPGGEDESACTPLVCKKDQFQCGNNRCMPFVWVCDGDIDCPDKSDEANCDNVSCGPNDFQCDSGRCIPLAWRCDDDHDCPNGEDEPASCFSSKATCDPTYFKCNNSKCIPGRWRCDYENDCGDGSDELNCQMRNCSESEFRCGTGKCIKHNYRCDGEIHCDDNSDEINCNITCKENQFKCAAFNTCINKQYKCDGDDDCPDGSDEVNCTCHSDHFSCGNGKCIMSRWKCDGWDDCLDGSDESLETCAKTHCHANAFKCRNQLCVRNSALCDGINDCGENEDESDAVCAALPKCRHDQFQCENDDCISKAFRCDGQYNCVDGSDEMNCQPPVCGFGSCSQICIEKKAGHYNCKCADGYHKGPEKNATCLASGPDQILLLASEQEFRFILPAKQEGTTVVGFFQTDSLKIDVFDILIRPKDTLLFWIDSHHGKVHTMKIATPHVEGTGVRVRRDLKELTAFNIPELDDPKSLAVDWISQRVYIIDSRHNQILATDIEGKKYISLVSTGMNPTDIVLEPESRIMIWSTLENGILVASLDGSNKKSLVERDVGWPISLSMDYPTGRLYWADYRKGTIETCRLNGKDRNVVRRFGNREKPQKIDVFEDYLYIKLYDQSIIKMNKFGNDNGTYLLKGYRSSDIGILHPMKQNRNISNPCAKDPCKSSRALCILSSESSVGYSCKCAEGYVMTDDGVCKAHADIPDYCPLQCNLGTCKIVDHVPKCICQPQFEGELCEHYRCSGYCQNYGVCSVAPALPGSQEPPPLKCTCTAGWSGARCETSMPACQSRCHNGGSCLISETEGMKCSCPKMFTGEQCEHCRNLTCENGGICRETLTGTPQCECPDGFTGKRCEIDECADFCKNGGSCVISTKGQRQCKCPSGYFGEHCESNSCRDFCRNGGTCSERGGRLSCTCPPRYIGESCESDLCKTSSPPHFCDNTKVPTRDPCTLMICQNAGTCHIIKGVALCNCTDQWNGDLCTLPVTDDNPCARYCANGGVCHLDEYRLPHCSCIGEWQGNACEMPPHCVGGECNVCRPGSSINECLCENNRVVPCLSDSADALKEEQEPTESGGVFSVVVLVLAVILLVFALFAGAVYFLKKHRIAQPFSHARLTDNVEIMLTNAMYRGDADEAPTFASEDDKGNFANPVYESMYADAIPEPVSTEITHSTAPDERKGLLQHTHDENHTPDIL", "length": 4752, "header": "tr|A0A0B4KFD1-1|A0A0B4KFD1_DROME Isoform 1 of LDL receptor protein 1, isoform F OS=Drosophila melanogaster OX=7227 GN=LRP1 PE=1 SV=1 CANONICAL=A0A0B4KFD1-1" }, "isoforms": [ { "isoform_ac": "A0A0B4KFD1-1", "url": "https://www.uniprot.org/uniprotkb/A0A0B4KFD1/entry#A0A0B4KFD1-1", "sequence": { "sequence": "MPATANSWILLLLLLVAVERCSSNSSGRINSRSSSSGYRKVQWQEQQEAPTLRPLPDKGNAHKSRNRIKPTVFIRPNAALTAGGGPCPASYFTCNDGFCIPMRWKCDSKADCPDMSDEGSECAPKCNEGQFRCGVSRHCIPNNWLCDGEFDCGKGDISDELNCPNGDTPKCRAFEGQCRNGDCLELSRFCDGRWDCDNDELQCDKQNAACAALNCSFNCKLTPQGARCYCPKDQVPESSNSTRCVDYDECSEPGTCDQVCRNTPGSYECSCVSGYAKTKGNRCRAINVPPTEPTTLIFLSRDGVQSVGTNGTEVIGPPGAKDNDKVTDKDGVGSEEELLLSQPLRFVHAFEVWHRNRTLCSLLFSWPELQMRCQRVDDARVNWTLPFSSFVSPQQFFTELRLDWLSGNWYLVSEDDGLVYLCTNAMTYCRVILQQVDPLSSLDLDPTKGFMFYTDWTPSLSRSLLDGSNRTVLVTDQVYHPSSVTLDLANELVYWIDIYKDEVNRVDYEGRNRWTLKRPLDSPVPLKTIHAVEVFENSIYLAAWMDTAIVALDKFSLKTHILQSNVSRGANLRIFHRQKQPEVAHPCRDNNAGCNQICVPQWTKGFASAKCMCTAGYKLHNQTTCLLSALDKFLVYSDKHLARISGIPLDTEQVQQLEQIGEQPDVMVPVYNVSKTLAIDVNVRGKAVFYVVADSGASPFGNGEPSCSIRSQSLNGSVSRLLAQGLKRVHAVAFDWINDHLYWTSHKKMQVAPLRNLSKVLTFNTDCDAMSLELDPTTGLLYWSQWESQSCEAGIYSSWMDGTHKELLAKGTSSMPMQWPRSLDVDRRTKELYWCDIRLSTIELMRLDGTGREVLFKSDQFHPYSIVQNNGLIYWADNKNSTILRFHAHQANLSSTFSSTVHLQRTGRAADLRIFDIASQPLPQTPSACAQSKCPGMCLNTPKGAICRCPDGFTLNGTGSHCIPQLAPSPIRPNCTSGYMCRSTRQCLDTKDMCDGFEDCEDGIDESSDPKGPCNVNTCDKTHNFVCNGRCYQRSLLCSTIPYCSDGTDQANCHQNTCNSNEFTCHKSGRCIQLTWVNDGVVDCGPDDDSDETSETIFASKCPEFDCNNGRCRQFADVCDGIDNCGNNADEMECEQECEHGEKYCRPIGCYGEMHMCDGIHDCLDFSDEANCNQTKSDNHPVTEWKELGECAPLEFACMFPFECIPDFLRCDGISHCFDKTDEFNCTHINTTRFDMNETVICEHPDRLCGFSKQCVTVDQLCDGKNDCEDTTDEGFLCADKLCDRGHECSHRCHNTPEGYICSCPDHLYLQPNGKRCSMQHACDHWDTCSQVCESSGKGYDCRCLDGFDLGFDRFTCKSTAPDEPYVIFTNRQDIKGINLKTLNVGNFYSSLRNIIALDFLYNNESNVEIYWTDVIDDKIYRGHLVGESLRNVEAVIHSGLSTTEGLAVDWVGKNLYWIDSNLDQIEVAKLNGSFRRTLIAGNMESPRAIALDPREGLLFWTDWDDNSPRIERASMSGDGRRMISTSWQLSAGWPNGLTLDYTQKRVYWVDAKSDSISSTMYDGSEHHVVLRNKEILSHPFAISVFENYVYWTDWRTTSVIRANKWNGSDVQVLQRTQSQPFGIQVLHSSRQPWDRNPCGENNGGCSHLCLLSGRGTFKCECPHVMRLDPANERNCVPNEQVLLFVMVDEIRGIDLHQPNHHTIPTIRQSPRLVAPQRIDFLVDESRIFWSDIQQNEISSAGISNGLIEPIINTNIEKPYGFAVDWIARNMYFSSGQIKCNILASNLKGEFASIIHEDLNMVDSIVLDPANGKMYWIHSASDGSMSQLEQSNLDGSSRSLIYQHENNLQSLTMDFDSQRLYYAYDNSGIAYYDIPRNETRKVLVASPITSISSLTVYNGTLYFPENIQSVIMQCEKEACSNMSYLRVNTKSIQSMKMFYADAQTGSNTCAEWAYRGGCQQLCLATSSIDHVCRCALGYDVEPNNPTGCVPRAEFIFYSIDVLQGVEMIDPSEQFDTPSPALVPISRVSSASFIDYLANTDTLYWGDNELGSISRVKRDGTQRETILEALNLVGYKQQDWLGGIAIDWVAGNIYWSDTKRNIIEVARLDGSHRYVVVSNLEKPTALAVDPLQGLLFYVTQQHIGRVGLDGSQPFVLVNQTRANWAVGSLVLDIEATKVYWCERYPDALMKVDYDGNLREQLLNESLNNPVALAKMGDYLYWAENKYNEGIIRVAPLANLSQSKVVLQTEQDAIRDLKIYSKHLQRGSNPCAHSNGACEQLCLFNGTSAVCACAHSRLASDGYSCEPYENFLLFSYRSNIESIHMTDHADKNWPVQMISNTSLMRNVIAITYNYEEQLVYYSDVQLSTINQVHFNGTGHRVLLEQQQRVEGLAYDIVNEQLFWTSNNNATIRSVELRHLSEHADQNQVHVKKVLSLREDDKPRGIAVEPCLGMIYWTNWNEGSPCIQRSYLTGYGTEVIIKTDIKMPNALTLDLEQQKLYWADARLDKIERTNYDGSNRVVLAHSTPKHAFAMAVYGDLLFWTDWVLHAVVRANKYTGTDVLFLREHVTRPMGIVAVQNTSINCDANQCKILNGQCEDVCILNKSGQATCHCTQGVLAPDGRRCIAPVNTSCGLSQYNCHSGECIPLELTCDNVTHCADGSDEFRSYCIFRQCPETHFMCQNHRCIPKEHKCDGEQQCGDGSDETPLLCKCQSEDIDMHPSNNNTKEMPDMFRCGSGECIPRKFLCDSLKDCRDFSDEKMCAPIPCEKNDMTFVHCGNSTICIMPRWRCDGDPDCPDGTDELDCANHTSLSCDPGQFRCASGNCIAGSWHCDGEKDCPDGSDEINCRTECRHNQFACDKTCIPASWQCDGKSDCEDGSDEGPQCPNRPCRPHLFQCKSSGRCIPQKWVCDGEKDCPSGLGDEGSEDEGPQCGGVAHIPDCPPPAHLCTSGLCIDSHYVCDGDEDCPGGDDEYEGCVPAFQPHSCPGGSLMHQCQDGLCIFKNQTCDGKPDCGDGSDETSSLCAHTRGCNGTDDFRCKNGACIHADLLCDRRNDCADFSDEELCNVNECLIPDICEHECEDKVVGYQCHCRPGYKVLPKSPHLCTDIDECDEQQPCSQTCINTYGSYKCLCAKGYALVDHHTCKATSNVSMELIFSNRYYIRQVDMTGNGSILINELSNAVALDYDWDSQCLYWSDVTSTVGTIKRYCPKENKTQTLHQAMLKNPDGLAVDWVAKNLYWCDKGLDTIEVSQLDGKYRKVLINEYLREPRGIALHPYQQHIFWSDWGDSPHIGKAGMDGSNPKMIIRDGLGWPNALTISFETQQLFWGDAREDTISVSDLDGNHTRLLLARSINPLLNLHHIFAIAVWEGHIYWSDWETKSIEYCSIFNGQNCTTLITTIHRPMDLRVFHPYRQQQPMSGNPCLAANCSTLCVLSPEEPYYKCMCPTNFILADDGRTCRANCTAAHFECVNTYKCIPFYWRCDTQDDCGDGSDEPETCPPFHCEPGQYQCANKKCTHPSNLCDGINQCGDGSDELNCDKFTCFDNHMKCGATANSSAFCVDNVKRCDGVKDCPGGEDESACTPLVCKKDQFQCGNNRCMPFVWVCDGDIDCPDKSDEANCDNVSCGPNDFQCDSGRCIPLAWRCDDDHDCPNGEDEPASCFSSKATCDPTYFKCNNSKCIPGRWRCDYENDCGDGSDELNCQMRNCSESEFRCGTGKCIKHNYRCDGEIHCDDNSDEINCNITCKENQFKCAAFNTCINKQYKCDGDDDCPDGSDEVNCTCHSDHFSCGNGKCIMSRWKCDGWDDCLDGSDESLETCAKTHCHANAFKCRNQLCVRNSALCDGINDCGENEDESDAVCAALPKCRHDQFQCENDDCISKAFRCDGQYNCVDGSDEMNCQPPVCGFGSCSQICIEKKAGHYNCKCADGYHKGPEKNATCLASGPDQILLLASEQEFRFILPAKQEGTTVVGFFQTDSLKIDVFDILIRPKDTLLFWIDSHHGKVHTMKIATPHVEGTGVRVRRDLKELTAFNIPELDDPKSLAVDWISQRVYIIDSRHNQILATDIEGKKYISLVSTGMNPTDIVLEPESRIMIWSTLENGILVASLDGSNKKSLVERDVGWPISLSMDYPTGRLYWADYRKGTIETCRLNGKDRNVVRRFGNREKPQKIDVFEDYLYIKLYDQSIIKMNKFGNDNGTYLLKGYRSSDIGILHPMKQNRNISNPCAKDPCKSSRALCILSSESSVGYSCKCAEGYVMTDDGVCKAHADIPDYCPLQCNLGTCKIVDHVPKCICQPQFEGELCEHYRCSGYCQNYGVCSVAPALPGSQEPPPLKCTCTAGWSGARCETSMPACQSRCHNGGSCLISETEGMKCSCPKMFTGEQCEHCRNLTCENGGICRETLTGTPQCECPDGFTGKRCEIDECADFCKNGGSCVISTKGQRQCKCPSGYFGEHCESNSCRDFCRNGGTCSERGGRLSCTCPPRYIGESCESDLCKTSSPPHFCDNTKVPTRDPCTLMICQNAGTCHIIKGVALCNCTDQWNGDLCTLPVTDDNPCARYCANGGVCHLDEYRLPHCSCIGEWQGNACEMPPHCVGGECNVCRPGSSINECLCENNRVVPCLSDSADALKEEQEPTESGGVFSVVVLVLAVILLVFALFAGAVYFLKKHRIAQPFSHARLTDNVEIMLTNAMYRGDADEAPTFASEDDKGNFANPVYESMYADAIPEPVSTEITHSTAPDERKGLLQHTHDENHTPDIL", "length": 4752, "header": "tr|A0A0B4KFD1-1|A0A0B4KFD1_DROME Isoform 1 of LDL receptor protein 1, isoform F OS=Drosophila melanogaster OX=7227 GN=LRP1 PE=1 SV=1 CANONICAL=A0A0B4KFD1-1" }, "locus": { "chromosome": "2R", "start_pos": 8225412, "end_pos": 8174657, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0344893", "url": "https://www.ensemblgenomes.org/id/FBtr0344893" }, { "database": "Ensembl Peptide", "id": "FBpp0311204", "url": "https://www.ensemblgenomes.org/id/FBpp0311204" } ] } }, { "isoform_ac": "A1Z7C4-1", "url": "https://www.uniprot.org/uniprotkb/A0A0B4KFD1/entry#A1Z7C4-1", "sequence": { "sequence": "MPATANSWILLLLLLVAVERCSSNSSGRINSRSSSSGYRKVQWQEQQEAPTLRPLPDKGPCPASYFTCNDGFCIPMRWKCDSKADCPDMSDEGSECAPKCNEGQFRCGVSRHCIPNNWLCDGEFDCGKGDISDELNCPNGDTPKCRAFEGQCRNGDCLELSRFCDGRWDCDNDELQCDKQNAACAALNCSFNCKLTPQGARCYCPKDQVPESSNSTRCVDYDECSEPGTCDQVCRNTPGSYECSCVSGYAKTKGNRCRAINVPPTEPTTLIFLSRDGVQSVGTNGTEVIGPPGAKDNDKVTDKDGVGSEEELLLSQPLRFVHAFEVWHRNRTLCSLLFSWPELQMRCQRVDDARVNWTLPFSSFVSPQQFFTELRLDWLSGNWYLVSEDDGLVYLCTNAMTYCRVILQQVDPLSSLDLDPTKGFMFYTDWTPSLSRSLLDGSNRTVLVTDQVYHPSSVTLDLANELVYWIDIYKDEVNRVDYEGRNRWTLKRPLDSPVPLKTIHAVEVFENSIYLAAWMDTAIVALDKFSLKTHILQSNVSRGANLRIFHRQKQPEVAHPCRDNNAGCNQICVPQWTKGFASAKCMCTAGYKLHNQTTCLLSALDKFLVYSDKHLARISGIPLDTEQVQQLEQIGEQPDVMVPVYNVSKTLAIDVNVRGKAVFYVVADSGASPFGNGEPSCSIRSQSLNGSVSRLLAQGLKRVHAVAFDWINDHLYWTSHKKMQVAPLRNLSKVLTFNTDCDAMSLELDPTTGLLYWSQWESQSCEAGIYSSWMDGTHKELLAKGTSSMPMQWPRSLDVDRRTKELYWCDIRLSTIELMRLDGTGREVLFKSDQFHPYSIVQNNGLIYWADNKNSTILRFHAHQANLSSTFSSTVHLQRTGRAADLRIFDIASQPLPQTPSACAQSKCPGMCLNTPKGAICRCPDGFTLNGTGSHCIPQLAPSPIRPNCTSGYMCRSTRQCLDTKDMCDGFEDCEDGIDESSDPKGPCNVNTCDKTHNFVCNGRCYQRSLLCSTIPYCSDGTDQANCHQNTCNSNEFTCHKSGRCIQLTWVNDGVVDCGPDDDSDETSETIFASKCPEFDCNNGRCRQFADVCDGIDNCGNNADEMECEQECEHGEKYCRPIGCYGEMHMCDGIHDCLDFSDEANCNQTKSDNHPVTEWKELGECAPLEFACMFPFECIPDFLRCDGISHCFDKTDEFNCTHINTTRFDMNETVICEHPDRLCGFSKQCVTVDQLCDGKNDCEDTTDEGFLCADKLCDRGHECSHRCHNTPEGYICSCPDHLYLQPNGKRCSMQHACDHWDTCSQVCESSGKGYDCRCLDGFDLGFDRFTCKSTAPDEPYVIFTNRQDIKGINLKTLNVGNFYSSLRNIIALDFLYNNESNVEIYWTDVIDDKIYRGHLVGESLRNVEAVIHSGLSTTEGLAVDWVGKNLYWIDSNLDQIEVAKLNGSFRRTLIAGNMESPRAIALDPREGLLFWTDWDDNSPRIERASMSGDGRRMISTSWQLSAGWPNGLTLDYTQKRVYWVDAKSDSISSTMYDGSEHHVVLRNKEILSHPFAISVFENYVYWTDWRTTSVIRANKWNGSDVQVLQRTQSQPFGIQVLHSSRQPWDRNPCGENNGGCSHLCLLSGRGTFKCECPHVMRLDPANERNCVPNEQVLLFVMVDEIRGIDLHQPNHHTIPTIRQSPRLVAPQRIDFLVDESRIFWSDIQQNEISSAGISNGLIEPIINTNIEKPYGFAVDWIARNMYFSSGQIKCNILASNLKGEFASIIHEDLNMVDSIVLDPANGKMYWIHSASDGSMSQLEQSNLDGSSRSLIYQHENNLQSLTMDFDSQRLYYAYDNSGIAYYDIPRNETRKVLVASPITSISSLTVYNGTLYFPENIQSVIMQCEKEACSNMSYLRVNTKSIQSMKMFYADAQTGSNTCAEWAYRGGCQQLCLATSSIDHVCRCALGYDVEPNNPTGCVPRAEFIFYSIDVLQGVEMIDPSEQFDTPSPALVPISRVSSASFIDYLANTDTLYWGDNELGSISRVKRDGTQRETILEALNLVGYKQQDWLGGIAIDWVAGNIYWSDTKRNIIEVARLDGSHRYVVVSNLEKPTALAVDPLQGLLFYVTQQHIGRVGLDGSQPFVLVNQTRANWAVGSLVLDIEATKVYWCERYPDALMKVDYDGNLREQLLNESLNNPVALAKMGDYLYWAENKYNEGIIRVAPLANLSQSKVVLQTEQDAIRDLKIYSKHLQRGSNPCAHSNGACEQLCLFNGTSAVCACAHSRLASDGYSCEPYENFLLFSYRSNIESIHMTDHADKNWPVQMISNTSLMRNVIAITYNYEEQLVYYSDVQLSTINQVHFNGTGHRVLLEQQQRVEGLAYDIVNEQLFWTSNNNATIRSVELRHLSEHADQNQVHVKKVLSLREDDKPRGIAVEPCLGMIYWTNWNEGSPCIQRSYLTGYGTEVIIKTDIKMPNALTLDLEQQKLYWADARLDKIERTNYDGSNRVVLAHSTPKHAFAMAVYGDLLFWTDWVLHAVVRANKYTGTDVLFLREHVTRPMGIVAVQNTSINCDANQCKILNGQCEDVCILNKSGQATCHCTQGVLAPDGRRCIAPVNTSCGLSQYNCHSGECIPLELTCDNVTHCADGSDEFRSYCIFRQCPETHFMCQNHRCIPKEHKCDGEQQCGDGSDETPLLCKCQSEDIDMHPSNNNTKEMPDMFRCGSGECIPRKFLCDSLKDCRDFSDEKMCAPIPCEKNDMTFVHCGNSTICIMPRWRCDGDPDCPDGTDELDCANHTSLSCDPGQFRCASGNCIAGSWHCDGEKDCPDGSDEINCRTECRHNQFACDKTCIPASWQCDGKSDCEDGSDEGPQCPNRPCRPHLFQCKSSGRCIPQKWVCDGEKDCPSGLGDEGSEDEGPQCGGVAHIPDCPPPAHLCTSGLCIDSHYVCDGDEDCPGGDDEYEGCVPAFQPHSCPGGSLMHQCQDGLCIFKNQTCDGKPDCGDGSDETSSLCAHTRGCNGTDDFRCKNGACIHADLLCDRRNDCADFSDEELCNVNECLIPDICEHECEDKVVGYQCHCRPGYKVLPKSPHLCTDIDECDEQQPCSQTCINTYGSYKCLCAKGYALVDHHTCKATSNVSMELIFSNRYYIRQVDMTGNGSILINELSNAVALDYDWDSQCLYWSDVTSTVGTIKRYCPKENKTQTLHQAMLKNPDGLAVDWVAKNLYWCDKGLDTIEVSQLDGKYRKVLINEYLREPRGIALHPYQQHIFWSDWGDSPHIGKAGMDGSNPKMIIRDGLGWPNALTISFETQQLFWGDAREDTISVSDLDGNHTRLLLARSINPLLNLHHIFAIAVWEGHIYWSDWETKSIEYCSIFNGQNCTTLITTIHRPMDLRVFHPYRQQQPMSGNPCLAANCSTLCVLSPEEPYYKCMCPTNFILADDGRTCRANCTAAHFECVNTYKCIPFYWRCDTQDDCGDGSDEPETCPPFHCEPGQYQCANKKCTHPSNLCDGINQCGDGSDELNCDKFTCFDNHMKCGATANSSAFCVDNVKRCDGVKDCPGGEDESACTPLVCKKDQFQCGNNRCMPFVWVCDGDIDCPDKSDEANCDNVSCGPNDFQCDSGRCIPLAWRCDDDHDCPNGEDEPASCFSSKATCDPTYFKCNNSKCIPGRWRCDYENDCGDGSDELNCQMRNCSESEFRCGTGKCIKHNYRCDGEIHCDDNSDEINCNITCKENQFKCAAFNTCINKQYKCDGDDDCPDGSDEVNCTCHSDHFSCGNGKCIMSRWKCDGWDDCLDGSDESLETCAKTHCHANAFKCRNQLCVRNSALCDGINDCGENEDESDAVCAALPKCRHDQFQCENDDCISKAFRCDGQYNCVDGSDEMNCQPPVCGFGSCSQICIEKKAGHYNCKCADGYHKGPEKNATCLASGPDQILLLASEQEFRFILPAKQEGTTVVGFFQTDSLKIDVFDILIRPKDTLLFWIDSHHGKVHTMKIATPHVEGTGVRVRRDLKELTAFNIPELDDPKSLAVDWISQRVYIIDSRHNQILATDIEGKKYISLVSTGMNPTDIVLEPESRIMIWSTLENGILVASLDGSNKKSLVERDVGWPISLSMDYPTGRLYWADYRKGTIETCRLNGKDRNVVRRFGNREKPQKIDVFEDYLYIKLYDQSIIKMNKFGNDNGTYLLKGYRSSDIGILHPMKQNRNISNPCAKDPCKSSRALCILSSESSVGYSCKCAEGYVMTDDGVCKAHADIPDYCPLQCNLGTCKIVDHVPKCICQPQFEGELCEHYRCSGYCQNYGVCSVAPALPGSQEPPPLKCTCTAGWSGARCETSMPACQSRCHNGGSCLISETEGMKCSCPKMFTGEQCEHCRNLTCENGGICRETLTGTPQCECPDGFTGKRCEIDECADFCKNGGSCVISTKGQRQCKCPSGYFGEHCESNSCRDFCRNGGTCSERGGRLSCTCPPRYIGESCESDLCKTSSPPHFCDNTKVPTRDPCTLMICQNAGTCHIIKGVALCNCTDQWNGDLCTLPVTDDNPCARYCANGGVCHLDEYRLPHCSCIGEWQGNACEMPPHCVGGECNVCRPGSSINECLCENNRVVPCLSDSADALKEEQEPTESGGVFSVVVLVLAVILLVFALFAGAVYFLKKHRIAQPFSHARLTDNVEIMLTNAMYRGDADEAPTFASEDDKFILQGNFANPVYESMYADAIPEPVSTEITHSTAPDERKGLLQHTHDENHTPDIL", "length": 4730, "header": "tr|A1Z7C4-1|A1Z7C4_DROME Computationally mapped isoform of LDL receptor protein 1, isoform G OS=Drosophila melanogaster OX=7227 GN=LRP1 PE=1 SV=2 CANONICAL=A0A0B4KFD1-1" }, "locus": { "chromosome": "2R", "start_pos": 8225412, "end_pos": 8174657, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0344894", "url": "https://www.ensemblgenomes.org/id/FBtr0344894" }, { "database": "Ensembl Peptide", "id": "FBpp0311205", "url": "https://www.ensemblgenomes.org/id/FBpp0311205" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "The genome sequence of Drosophila melanogaster.", "journal": "Science", "date": "2000", "authors": "Adams MD, Celniker SE, Holt RA, Evans CA, Gocayne JD, Amanatides PG, Scherer SE, Li PW, Hoskins RA, Galle RF, George RA, Lewis SE, Richards S, Ashburner M, Henderson SN, Sutton GG, Wortman JR, Yandell MD, Zhang Q, Chen LX, Brandon RC, Rogers YH, Blazej RG, Champe M, Pfeiffer BD, Wan KH, Doyle C, Baxter EG, Helt G, Nelson CR, Gabor GL, Abril JF, Agbayani A, An HJ, Andrews-Pfannkoch C, Baldwin D, Ballew RM, Basu A, Baxendale J, Bayraktaroglu L, Beasley EM, Beeson KY, Benos PV, Berman BP, Bhandari D, Bolshakov S, Borkova D, Botchan MR, Bouck J, Brokstein P, Brottier P, Burtis KC, Busam DA, Butler H, Cadieu E, Center A, Chandra I, Cherry JM, Cawley S, Dahlke C, Davenport LB, Davies P, de Pablos B, Delcher A, Deng Z, Mays AD, Dew I, Dietz SM, Dodson K, Doup LE, Downes M, Dugan-Rocha S, Dunkov BC, Dunn P, Durbin KJ, Evangelista CC, Ferraz C, Ferriera S, Fleischmann W, Fosler C, Gabrielian AE, Garg NS, Gelbart WM, Glasser K, Glodek A, Gong F, Gorrell JH, Gu Z, Guan P, Harris M, Harris NL, Harvey D, Heiman TJ, Hernandez JR, Houck J, Hostin D, Houston KA, Howland TJ, Wei MH, Ibegwam C, Jalali M, Kalush F, Karpen GH, Ke Z, Kennison JA, Ketchum KA, Kimmel BE, Kodira CD, Kraft C, Kravitz S, Kulp D, Lai Z, Lasko P, Lei Y, Levitsky AA, Li J, Li Z, Liang Y, Lin X, Liu X, Mattei B, McIntosh TC, McLeod MP, McPherson D, Merkulov G, Milshina NV, Mobarry C, Morris J, Moshrefi A, Mount SM, Moy M, Murphy B, Murphy L, Muzny DM, Nelson DL, Nelson DR, Nelson KA, Nixon K, Nusskern DR, Pacleb JM, Palazzolo M, Pittman GS, Pan S, Pollard J, Puri V, Reese MG, Reinert K, Remington K, Saunders RD, Scheeler F, Shen H, Shue BC, Siden-Kiamos I, Simpson M, Skupski MP, Smith T, Spier E, Spradling AC, Stapleton M, Strong R, Sun E, Svirskas R, Tector C, Turner R, Venter E, Wang AH, Wang X, Wang ZY, Wassarman DA, Weinstock GM, Weissenbach J, Williams SM, WoodageT, Worley KC, Wu D, Yang S, Yao QA, Ye J, Yeh RF, Zaveri JS, Zhan M, Zhang G, Zhao Q, Zheng L, Zheng XH, Zhong FN, Zhong W, Zhou X, Zhu S, Zhu X, Smith HO, Gibbs RA, Myers EW, Rubin GM, Venter JC", "evidence": [ { "database": "UniProtKB", "id": "A0A0B4KFD1", "url": "https://www.uniprot.org/uniprot/A0A0B4KFD1" } ], "reference": [ { "type": "PubMed", "id": "10731132", "url": "https://glygen.org/publication/PubMed/10731132" } ] }, { "title": "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence.", "journal": "Genome Biol.", "date": "2002", "authors": "Celniker SE, Wheeler DA, Kronmiller B, Carlson JW, Halpern A, Patel S, Adams M, Champe M, Dugan SP, Frise E, Hodgson A, George RA, Hoskins RA, Laverty T, Muzny DM, Nelson CR, Pacleb JM, Park S, Pfeiffer BD, Richards S, Sodergren EJ, Svirskas R, Tabor PE, Wan K, Stapleton M, Sutton GG, Venter C, Weinstock G, Scherer SE, Myers EW, Gibbs RA, Rubin GM", "evidence": [ { "database": "UniProtKB", "id": "A0A0B4KFD1", "url": "https://www.uniprot.org/uniprot/A0A0B4KFD1" } ], "reference": [ { "type": "PubMed", "id": "12537568", "url": "https://glygen.org/publication/PubMed/12537568" } ] }, { "title": "Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.", "journal": "Genome Biol.", "date": "2002", "authors": "Misra S, Crosby MA, Mungall CJ, Matthews BB, Campbell KS, Hradecky P, Huang Y, Kaminker JS, Millburn GH, Prochnik SE, Smith CD, Tupy JL, Whitfied EJ, Bayraktaroglu L, Berman BP, Bettencourt BR, Celniker SE, de Grey AD, Drysdale RA, Harris NL, Richter J, Russo S, Schroeder AJ, Shu SQ, Stapleton M, Yamada C, Ashburner M, Gelbart WM, Rubin GM, Lewis SE", "evidence": [ { "database": "UniProtKB", "id": "A0A0B4KFD1", "url": "https://www.uniprot.org/uniprot/A0A0B4KFD1" } ], "reference": [ { "type": "PubMed", "id": "12537572", "url": "https://glygen.org/publication/PubMed/12537572" } ] }, { "title": "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective.", "journal": "Genome Biol.", "date": "2002", "authors": "Kaminker JS, Bergman CM, Kronmiller B, Carlson J, Svirskas R, Patel S, Frise E, Wheeler DA, Lewis SE, Rubin GM, Ashburner M, Celniker SE", "evidence": [ { "database": "UniProtKB", "id": "A0A0B4KFD1", "url": "https://www.uniprot.org/uniprot/A0A0B4KFD1" } ], "reference": [ { "type": "PubMed", "id": "12537573", "url": "https://glygen.org/publication/PubMed/12537573" } ] }, { "title": "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.", "journal": "Genome Biol.", "date": "2002", "authors": "Hoskins RA, Smith CD, Carlson JW, Carvalho AB, Halpern A, Kaminker JS, Kennedy C, Mungall CJ, Sullivan BA, Sutton GG, Yasuhara JC, Wakimoto BT, Myers EW, Celniker SE, Rubin GM, Karpen GH", "evidence": [ { "database": "UniProtKB", "id": "A0A0B4KFD1", "url": "https://www.uniprot.org/uniprot/A0A0B4KFD1" } ], "reference": [ { "type": "PubMed", "id": "12537574", "url": "https://glygen.org/publication/PubMed/12537574" } ] }, { "title": "Combined evidence annotation of transposable elements in genome sequences.", "journal": "PLoS Comput. Biol.", "date": "2005", "authors": "Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D", "evidence": [ { "database": "UniProtKB", "id": "A0A0B4KFD1", "url": "https://www.uniprot.org/uniprot/A0A0B4KFD1" } ], "reference": [ { "type": "PubMed", "id": "16110336", "url": "https://glygen.org/publication/PubMed/16110336" } ] }, { "title": "The Release 5.1 annotation of Drosophila melanogaster heterochromatin.", "journal": "Science", "date": "2007", "authors": "Smith CD, Shu S, Mungall CJ, Karpen GH", "evidence": [ { "database": "UniProtKB", "id": "A0A0B4KFD1", "url": "https://www.uniprot.org/uniprot/A0A0B4KFD1" } ], "reference": [ { "type": "PubMed", "id": "17569856", "url": "https://glygen.org/publication/PubMed/17569856" } ] }, { "title": "Sequence finishing and mapping of Drosophila melanogaster heterochromatin.", "journal": "Science", "date": "2007", "authors": "Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE", "evidence": [ { "database": "UniProtKB", "id": "A0A0B4KFD1", "url": "https://www.uniprot.org/uniprot/A0A0B4KFD1" } ], "reference": [ { "type": "PubMed", "id": "17569867", "url": "https://glygen.org/publication/PubMed/17569867" } ] } ], "pathway": [ { "id": "dme:Dmel_CG33087", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?dme:Dmel_CG33087", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6AQY2-1", "protein_name": "LDL receptor related protein 1B", "gene_name": "Lrp1b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": 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