{ "uniprot_canonical_ac": "A0A096MJN4-1", "uniprot_ac": "A0A096MJN4", "uniprot_id": "SEPT4_RAT", "mass": { "chemical_mass": 53083.0, "monoisotopic_mass": 53083.0 }, "refseq": { "ac": "XP_017452610", "name": "septin-4 isoform 5", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017452610" }, "gene_names": [ { "name": "Septin4", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A096MJN4", "id": "A0A096MJN4" }, { "name": "Arts", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A096MJN4", "id": "A0A096MJN4" }, { "name": "Bh5", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A096MJN4", "id": "A0A096MJN4" }, { "name": "EG3-1RVC; EG3RVC; hCDCREL-2; Pnutl2; Sept4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017452610", "id": "XP_017452610" }, { "name": "Gm11492", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A096MJN4", "id": "A0A096MJN4" }, { "name": "Pnut12", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A096MJN4", "id": "A0A096MJN4" }, { "name": "Sep4", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A096MJN4", "id": "A0A096MJN4" }, { "name": "Sept4", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A096MJN4", "id": "A0A096MJN4" }, { "name": "Septin4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017452610", "id": "XP_017452610" } ], "protein_names": [ { "name": "Septin-4", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A096MJN4/entry#names_and_taxonomy", "id": "A0A096MJN4" }, { "name": "Apoptosis-related protein in the TGF-beta signaling pathway", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A096MJN4/entry#names_and_taxonomy", "id": "A0A096MJN4" }, { "name": "Arts", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A096MJN4/entry#names_and_taxonomy", "id": "A0A096MJN4" }, { "name": "Bradeion beta", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A096MJN4/entry#names_and_taxonomy", "id": "A0A096MJN4" }, { "name": "Brain protein H5", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A096MJN4/entry#names_and_taxonomy", "id": "A0A096MJN4" }, { "name": "CE5B3 beta", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A096MJN4/entry#names_and_taxonomy", "id": "A0A096MJN4" }, { "name": "Cell division control-related protein 2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A096MJN4/entry#names_and_taxonomy", "id": "A0A096MJN4" }, { "name": "Peanut-like protein 2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A096MJN4/entry#names_and_taxonomy", "id": "A0A096MJN4" }, { "name": "expression gene 3 in rat visual cortex; expression gene 3-1 in rat visual cortex; peanut-like 2; arts; CE5B3 beta; bradeion beta; brain protein H5; peanut-like protein 2; cell division control-related protein 2; apoptosis-related protein in the TGF-beta signaling pathway", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017452610", "id": "XP_017452610" }, { "name": "hCDCREL-2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A096MJN4/entry#names_and_taxonomy", "id": "A0A096MJN4" }, { "name": "septin-4 isoform 5", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017452610", "id": "XP_017452610" } ], "function": [ { "annotation": "Filament-forming cytoskeletal GTPase.", "evidence": [ { "database": "UniProtKB", "id": "E9PST0", "url": "https://www.uniprot.org/uniprot/E9PST0#function" }, { "database": "UniProtKB", "id": "PIRNR006698", "url": "https://www.uniprot.org/uniprot/PIRNR006698#function" } ] }, { "annotation": "Filament-forming cytoskeletal GTPase. Pro-apoptotic protein involved in LGR5-positive intestinal stem cell and Paneth cell expansion in the intestines, via its interaction with XIAP (By similarity). May also play a role in the regulation of cell fate in the intestine (By similarity). Positive regulator of apoptosis involved in hematopoietic stem cell homeostasis; via its interaction with XIAP (By similarity). Negative regulator of repair and hair follicle regeneration in response to injury, due to inhibition of hair follicle stem cell proliferation, potentially via its interaction with XIAP (By similarity). Plays an important role in male fertility and sperm motility (By similarity). During spermiogenesis, essential for the establishment of the annulus (a fibrous ring structure connecting the midpiece and the principal piece of the sperm flagellum) which is a requisite for the structural and mechanical integrity of the sperm (By similarity). Involved in the migration of cortical neurons and the formation of neuron leading processes during embryonic development (By similarity). Required for dopaminergic metabolism in presynaptic autoreceptors; potentially via activity as a presynaptic scaffold protein (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJN4", "url": "https://www.uniprot.org/uniprot/A0A096MJN4#function" }, { "database": "UniProtKB", "id": "P28661", "url": "https://www.uniprot.org/uniprot/P28661#function" } ] } ], "disease": [ { "disease_id": "DOID:12217", "recommended_name": { "id": "DOID:12217", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:12217", "name": "Lewy body dementia", "description": "A dementia that is characterized by the development of abnormal proteinaceous (alpha-synuclein) cytoplasmic inclusions, called Lewy bodies, throughout the brain that results in progressive decline in mental abilities." }, "synonyms": [ { "id": "DOID:12217", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:12217", "name": "Dementia with Lewy bodies", "description": "" }, { "id": "DOID:12217", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:12217", "name": "Diffuse Lewy body disease", "description": "" }, { "id": "DOID:12217", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:12217", "name": "Lewy body disease", "description": "" }, { "id": "DOID:12217", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:12217", "name": "Senile dementia of the Lewy body type", "description": "" }, { "id": "MONDO:0007488", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007488", "name": "Lewy body dementia", "description": "A progressive form of dementia characterized by the presence of protein deposits called Lewy bodies in the midbrain and cerebral cortex, and loss of cholinergic and dopaminergic neurons. The signs and symptoms overlap with Alzheimer and Parkinson disease." }, { "id": "MONDO:0007488", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007488", "name": "DLB", "description": "" }, { "id": "MONDO:0007488", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007488", "name": "Lewy body dementia", "description": "" }, { "id": "MONDO:0007488", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007488", "name": "Lewy body disease", "description": "" }, { "id": "MONDO:0007488", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007488", "name": "Senile dementia of the Lewy body type", "description": "" }, { "id": "MONDO:0007488", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007488", "name": "cortical Lewy body disease", "description": "" }, { "id": "MONDO:0007488", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007488", "name": "dementia with Lewy bodies", "description": "" }, { "id": "MONDO:0007488", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007488", "name": "lewy body dementia, susceptibility to", "description": "" }, { "id": "MONDO:0007488", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007488", "name": "Lewy body variant of Alzheimer disease", "description": "" }, { "id": "MONDO:0007488", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007488", "name": "dementia, Lewy body", "description": "" }, { "id": "MONDO:0007488", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007488", "name": "diffuse Lewy body disease", "description": "" }, { "id": "MONDO:0007488", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007488", "name": "diffuse Lewy body disease with gaze palsy", "description": "" }, { "id": "MIM:127750", "resource": "MIM", "url": "https://www.omim.org/entry/127750", "name": "Dementia, Lewy body", "description": "Dementia, Lewy body" } ], "evidence": [ { "id": "12217", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:12217" } ] }, { "disease_id": "DOID:14330", "recommended_name": { "id": "DOID:14330", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:14330", "name": "Parkinson's disease", "description": "A synucleinopathy that has_material_basis_in degeneration of the central nervous system that often impairs motor skills, speech, and other functions." }, "synonyms": [ { "id": "DOID:14330", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:14330", "name": "Parkinson disease", "description": "" }, { "id": "DOID:14330", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:14330", "name": "paralysis agitans", "description": "" }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "late-onset Parkinson disease", "description": "A Parkinson disease that begins after around the age of 50." }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "LOPD", "description": "" }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "PARK", "description": "" }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "PD", "description": "" }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "Parkinson disease, age of onset, modifier, Multifactorial", "description": "" }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "Parkinson disease, late-onset", "description": "" }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "Parkinson disease, late-onset, susceptibility to, Multifactorial", "description": "" }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "Parkinson disease, susceptibility to, Multifactorial", "description": "" }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "autosomal dominant late-onset Parkinson disease", "description": "" }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "hereditary late onset Parkinson disease", "description": "" }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "hereditary late-onset Parkinson disease", "description": "" }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "late onset Parkinson disease", "description": "" }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "late onset Parkinson's disease", "description": "" }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "late-onset Parkinson disease", "description": "" }, { "id": "MIM:168600", "resource": "MIM", "url": "https://www.omim.org/entry/168600", "name": "Parkinson disease", "description": "Parkinson disease" } ], "evidence": [ { "id": "14330", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:14330" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A096MJN4", "url": "https://www.uniprot.org/uniprot/A0A096MJN4" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "gene": [ { "name": "Septin4", "url": "https://www.uniprot.org/uniprot/A0A096MJN4", "locus": { "chromosome": "10", "start_pos": 72390768, "end_pos": 72366873, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000007367", "url": "https://www.ensembl.org/id/ENSRNOG00000007367" } ] } } ], "crossref": [ { "id": "A0A096MJN4", "url": "https://alphafold.ebi.ac.uk/entry/A0A096MJN4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSRNOG00000007367", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000007367", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01850", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01850", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "287606", "url": "https://www.ncbi.nlm.nih.gov/gene/287606", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR016491", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016491", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030379", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030379", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "RNRTIMA", "url": "https://omabrowser.org/oma/group/RNRTIMA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A096MJN4", "url": "https://www.orthodb.org/?gene=A0A096MJN4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A096MJT3", "url": "https://www.orthodb.org/?gene=A0A096MJT3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A096MJW0", "url": "https://www.orthodb.org/?gene=A0A096MJW0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E9PST0", "url": "https://www.orthodb.org/?gene=E9PST0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR18884", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18884", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR18884:SF71", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18884:SF71", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00735", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00735", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF15548", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15548", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_A0A096MJN4", "url": "http://purl.obolibrary.org/obo/PR_A0A096MJN4", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-RNO-111457", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-111457", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-111469", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-111469", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "XP_017452610", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017452610", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "1308781", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1308781", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "A0A096MJN4", "url": "https://www.uniprot.org/uniprot/A0A096MJN4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A096MJN4-1", "url": "https://www.uniprot.org/uniprot/A0A096MJN4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A096MJT3", "url": "https://www.uniprot.org/uniprot/A0A096MJT3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A096MJT3-1", "url": "https://www.uniprot.org/uniprot/A0A096MJT3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A096MJW0", "url": "https://www.uniprot.org/uniprot/A0A096MJW0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A096MJW0-1", "url": "https://www.uniprot.org/uniprot/A0A096MJW0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2JVC7", "url": "https://www.uniprot.org/uniprot/A0A0G2JVC7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2JVC7-1", "url": "https://www.uniprot.org/uniprot/A0A0G2JVC7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6AD62", "url": "https://www.uniprot.org/uniprot/A0A8I6AD62", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6AD62-1", "url": "https://www.uniprot.org/uniprot/A0A8I6AD62-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6AGT3", "url": "https://www.uniprot.org/uniprot/A0A8I6AGT3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6AGT3-1", "url": "https://www.uniprot.org/uniprot/A0A8I6AGT3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0JN02", "url": "https://www.uniprot.org/uniprot/A0JN02", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0JN02-1", "url": "https://www.uniprot.org/uniprot/A0JN02-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E9PST0", "url": "https://www.uniprot.org/uniprot/E9PST0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E9PST0-1", "url": "https://www.uniprot.org/uniprot/E9PST0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MIKHFLEDNSDDAELSKFVKDFPGSEPCHPTESKTRVARPQILEPRPQSPDLCDDDVEFRATLWSQPSDSQQYFCPPAPLSPSSRPRSPWGKLDPYDSSEDDKEYVGFATLPNQVHRKSVKKGFDFTLMVAGESGLGKSTLVNSLFLTDLYRDRKLLGAEERIMQTVEITKHAVDIEEKGVRLRLTIVDTPGFGDAVNNTECWRPVAEYIDQQFEQYFRDESGLNRKNIQDNRVHCCLYFISPFGHGLRPLDVEFMKALHQRVNIVPILAKADTLTPSEVDRKKCKIREEIEHFGIKIYQFPDCDSDEDEDFKLQDQALKESIPFAVIGSNTVVEARGRRVRGRLYPWGIVEVENPGHCDFVKLRTMLVRTHMQDLKDVTRETHYENYRAQCIQSMTRLVVKERNRNKLTRESGTDFPIPAVPPGTDPETEKLIREKDEELRRMQEMLHKIQRQMKETH", "length": 459, "header": "sp|A0A096MJN4-1|SEPT4_RAT Isoform 1 of Septin-4 OS=Rattus norvegicus OX=10116 GN=Septin4 PE=1 SV=1 CANONICAL=A0A096MJN4-1" }, "isoforms": [ { "isoform_ac": "A0A096MJN4-1", "url": "https://www.uniprot.org/uniprotkb/A0A096MJN4/entry#A0A096MJN4-1", "sequence": { "sequence": "MIKHFLEDNSDDAELSKFVKDFPGSEPCHPTESKTRVARPQILEPRPQSPDLCDDDVEFRATLWSQPSDSQQYFCPPAPLSPSSRPRSPWGKLDPYDSSEDDKEYVGFATLPNQVHRKSVKKGFDFTLMVAGESGLGKSTLVNSLFLTDLYRDRKLLGAEERIMQTVEITKHAVDIEEKGVRLRLTIVDTPGFGDAVNNTECWRPVAEYIDQQFEQYFRDESGLNRKNIQDNRVHCCLYFISPFGHGLRPLDVEFMKALHQRVNIVPILAKADTLTPSEVDRKKCKIREEIEHFGIKIYQFPDCDSDEDEDFKLQDQALKESIPFAVIGSNTVVEARGRRVRGRLYPWGIVEVENPGHCDFVKLRTMLVRTHMQDLKDVTRETHYENYRAQCIQSMTRLVVKERNRNKLTRESGTDFPIPAVPPGTDPETEKLIREKDEELRRMQEMLHKIQRQMKETH", "length": 459, "header": "sp|A0A096MJN4-1|SEPT4_RAT Isoform 1 of Septin-4 OS=Rattus norvegicus OX=10116 GN=Septin4 PE=1 SV=1 CANONICAL=A0A096MJN4-1" }, "locus": { "chromosome": "10", "start_pos": 72390600, "end_pos": 72378826, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000076026.3", "url": "https://www.ensembl.org/id/ENSRNOT00000076026.3" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000068198.1", "url": "https://www.ensembl.org/id/ENSRNOP00000068198.1" } ] } }, { "isoform_ac": "A0A096MJT3-1", "url": "https://www.uniprot.org/uniprotkb/A0A096MJN4/entry#A0A096MJT3-1", "sequence": { "sequence": "MASTQKATVFQVYKTNKNGSKVAVSSHRGAEVTTSAPQRTHGYYSSSQRAAAVSLSPPPPPSQKRAEAASTTHHSTSDYPRSVCPQSGPGLSAVSTSRGTETRTRVEVPRHHSPHHSPHRKNQSVQTLSSHLAGVNRTVSPVREDSTRRTENKPGREVGYHSSMASDAKYRHLYFTREKEEDPPSKVQNPQGVKVPRRVSACPKDEAIQTEPTRRTTAEVKSSRNVFVQEHSSRTANTPQIVIRKIPPQEPEVGHSSVLSEPKTSQKTTKLSTGLKFSVLRDLDGAPRAPPPRPERSFCIETKPPKILISETEPTVRSPPREREVGRKVTISPGKQSMQSPHHVTCRTVSEGTYKSPLYSELSPKPSTQATAAFELTPRPLPPRSLPKYGPDCSWWALLNPKVETPQNQSIFDFEPKSPPFLDPLESFYEMDSTSFCEDLMFQRDKASLPPSPKESLYRVPLTEVQKTPKCTSKQPSQGFNAFFLDVSEEMYNRILWWLKDEEIKHFLEDNSDDAELSKFVKDFPGSEPCHPTESKTRVARPQILEPRPQSPDLCDDDVEFRATLWSQPSDSQQYFCPPAPLSPSSRPRSPWGKLDPYDSSEDDKEYVGFATLPNQVHRKSVKKGFDFTLMVAGESGLGKSTLVNSLFLTDLYRDRKLLGAEERIMQTVEITKHAVDIEEKGVRLRLTIVDTPGFGDAVNNTECWRPVAEYIDQQFEQYFRDESGLNRKNIQDNRVHCCLYFISPFGHGLRPLDVEFMKALHQRVNIVPILAKADTLTPSEVDRKKCKIREEIEHFGIKIYQFPDCDSDEDEDFKLQDQALKESIPFAVIGSNTVVEARGRRVRGRLYPWGIVEVENPGHCDFVKLRTMLVRTHMQDLKDVTRETHYENYRAQCIQSMTRLVVKERNRNKLTRESGTDFPIPAVPPGTDPETEKLIREKDEELRRMQEMLHKIQRQMKETH", "length": 961, "header": "tr|A0A096MJT3-1|A0A096MJT3_RAT Computationally mapped isoform of Septin-4 OS=Rattus norvegicus OX=10116 GN=Septin4 PE=1 SV=2 CANONICAL=A0A096MJN4-1" }, "locus": { "chromosome": "10", "start_pos": 72390600, "end_pos": 72366873, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000076995.3", "url": "https://www.ensembl.org/id/ENSRNOT00000076995.3" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000068253.2", "url": "https://www.ensembl.org/id/ENSRNOP00000068253.2" } ] } }, { "isoform_ac": "A0A096MJW0-1", "url": "https://www.uniprot.org/uniprotkb/A0A096MJN4/entry#A0A096MJW0-1", "sequence": { "sequence": "MDHSLGWQGNPVPEDGTEAGIKHFLEDNSDDAELSKFVKDFPGSEPCHPTESKTRVARPQILEPRPQSPDLCDDDVEFRATLWSQPSDSQQYFCPPAPLSPSSRPRSPWGKLDPYDSSEDDKEYVGFATLPNQVHRKSVKKGFDFTLMVAGESGLGKSTLVNSLFLTDLYRDRKLLGAEERIMQTVEITKHAVDIEEKGVRLRLTIVDTPGFGDAVNNTECWRPVAEYIDQQFEQYFRDESGLNRKNIQDNRVHCCLYFISPFGHGLRPLDVEFMKALHQRVNIVPILAKADTLTPSEVDRKKCKIREEIEHFGIKIYQFPDCDSDEDEDFKLQDQALKESIPFAVIGSNTVVEARGRRVRGRLYPWGIVEVENPGHCDFVKLRTMLVRTHMQDLKDVTRETHYENYRAQCIQSMTRLVVKERNRNKLTRESGTDFPIPAVPPGTDPETEKLIREKDEELRRMQEMLHKIQRQMKETH", "length": 478, "header": "tr|A0A096MJW0-1|A0A096MJW0_RAT Computationally mapped isoform of Septin-4 OS=Rattus norvegicus OX=10116 GN=Septin4 PE=1 SV=2 CANONICAL=A0A096MJN4-1" }, "locus": { "chromosome": "10", "start_pos": 72390600, "end_pos": 72381415, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000076050.3", "url": "https://www.ensembl.org/id/ENSRNOT00000076050.3" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000068282.2", "url": "https://www.ensembl.org/id/ENSRNOP00000068282.2" } ] } }, { "isoform_ac": "A0A0G2JVC7-1", "url": "https://www.uniprot.org/uniprotkb/A0A096MJN4/entry#A0A0G2JVC7-1", "sequence": { "sequence": "MTRIHRKSVKKGFDFTLMVAGESGLGKSTLVNSLFLTDLYRDRKLLGAEERIMQTVEITKHAVDIEEKGVRLRLTIVDTPGFGDAVNNTECWRPVAEYIDQQFEQYFRDESGLNRKNIQDNRVHCCLYFISPFGHGLRPLDVEFMKALHQRVNIVPILAKADTLTPSEVDRKKCKIREEIEHFGIKIYQFPDCDSDEDEDFKLQDQALKESIPFAVIGSNTVVEARGRRVRGRLYPWGIVEVENPGHCDFVKLRTMLVRTHMQDLKDVTRETHYENYRAQCIQSMTRLVVKERNRKDRSRN", "length": 301, "header": "tr|A0A0G2JVC7-1|A0A0G2JVC7_RAT Computationally mapped isoform of Septin-4 OS=Rattus norvegicus OX=10116 GN=Septin4 PE=1 SV=2 CANONICAL=A0A096MJN4-1" }, "locus": { "chromosome": "10", "start_pos": 72390286, "end_pos": 72384103, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000085052.2", "url": "https://www.ensembl.org/id/ENSRNOT00000085052.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000069431.2", "url": "https://www.ensembl.org/id/ENSRNOP00000069431.2" } ] } }, { "isoform_ac": "A0A8I6AD62-1", "url": "https://www.uniprot.org/uniprotkb/A0A096MJN4/entry#A0A8I6AD62-1", "sequence": { "sequence": "KKQNLAQARVPQAAPTPTVSLLVCPCPSWRPVAEYIDQQFEQYFRDESGLNRKNIQDNRVHCCLYFISPFGHGSGRRSSTLESRSISSQIVILMRMRTSNYRTKP", "length": 105, "header": "tr|A0A8I6AD62-1|A0A8I6AD62_RAT Computationally mapped isoform of Septin 4 OS=Rattus norvegicus OX=10116 GN=Septin4 PE=3 SV=1 CANONICAL=A0A096MJN4-1" }, "locus": { "chromosome": "10", "start_pos": 72389557, "end_pos": 72388922, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000076841.2", "url": "https://www.ensembl.org/id/ENSRNOT00000076841.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000091143.1", "url": "https://www.ensembl.org/id/ENSRNOP00000091143.1" } ] } }, { "isoform_ac": "A0A8I6AGT3-1", "url": "https://www.uniprot.org/uniprotkb/A0A096MJN4/entry#A0A8I6AGT3-1", "sequence": { "sequence": "KIKHFLEDNSDDAELSKFVKDFPGSEPCHPTESKTRVARPQILEPRPQSPDLCDDDVEFRATLWSQPSDSQQYFCPPAPLSPSSRPR", "length": 87, "header": "tr|A0A8I6AGT3-1|A0A8I6AGT3_RAT Computationally mapped isoform of Septin 4 OS=Rattus norvegicus OX=10116 GN=Septin4 PE=4 SV=1 CANONICAL=A0A096MJN4-1" }, "locus": { "chromosome": "10", "start_pos": 72383765, "end_pos": 72369105, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000076078.2", "url": "https://www.ensembl.org/id/ENSRNOT00000076078.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000091935.1", "url": "https://www.ensembl.org/id/ENSRNOP00000091935.1" } ] } }, { "isoform_ac": "A0JN02-1", "url": "https://www.uniprot.org/uniprotkb/A0A096MJN4/entry#A0JN02-1", "sequence": { "sequence": "MDDKEYVGFATLPNQVHRKSVKKGFDFTLMVAGESGLGKSTLVNSLFLTDLYRDRKLLGAEERIMQTVEITKHAVDIEEKGVRLRLTIVDTPGFGDAVNNTECWRPVAEYIDQQFEQYFRDESGLNRKNIQDNRVHCCLYFISPFGHGLRPLDVEFMKALHQRVNIVPILAKADTLTPSEVDRKKCKIREEIEHFGIKIYQFPDCDSDEDEDFKLQDQALKESIPFAVIGSNTVVEARGRRVRGRLYPWGIVEVENPGHCDFVKLRTMLVRTHMQDLKDVTRETHYENYRAQCIQSMTRLVVKERNRKYDQKPGQSWPGESQVLPLLLCRPQASLKLVLGSPQPYYPPFPLSSAS", "length": 355, "header": "tr|A0JN02-1|A0JN02_RAT Computationally mapped isoform of Septin-4 OS=Rattus norvegicus OX=10116 GN=Septin4 PE=1 SV=1 CANONICAL=A0A096MJN4-1" }, "locus": { "chromosome": "10", "start_pos": 72390222, "end_pos": 72378826, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000088581.2", "url": "https://www.ensembl.org/id/ENSRNOT00000088581.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000072349.1", "url": "https://www.ensembl.org/id/ENSRNOP00000072349.1" } ] } }, { "isoform_ac": "E9PST0-1", "url": "https://www.uniprot.org/uniprotkb/A0A096MJN4/entry#E9PST0-1", "sequence": { "sequence": "MDHSLGWQGNPVPEDGTEAGDDKEYVGFATLPNQVHRKSVKKGFDFTLMVAGESGLGKSTLVNSLFLTDLYRDRKLLGAEERIMQTVEITKHAVDIEEKGVRLRLTIVDTPGFGDAVNNTECWRPVAEYIDQQFEQYFRDESGLNRKNIQDNRVHCCLYFISPFGHGLRPLDVEFMKALHQRVNIVPILAKADTLTPSEVDRKKCKIREEIEHFGIKIYQFPDCDSDEDEDFKLQDQALKESIPFAVIGSNTVVEARGRRVRGRLYPWGIVEVENPGHCDFVKLRTMLVRTHMQDLKDVTRETHYENYRAQCIQSMTRLVVKERNRNKLTRESGTDFPIPAVPPGTDPETEKLIREKDEELRRMQEMLHKIQRQMKETH", "length": 379, "header": "tr|E9PST0-1|E9PST0_RAT Computationally mapped isoform of Septin OS=Rattus norvegicus OX=10116 GN=Septin4 PE=1 SV=3 CANONICAL=A0A096MJN4-1" }, "locus": { "chromosome": "10", "start_pos": 72390600, "end_pos": 72381415, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000044226.5", "url": "https://www.ensembl.org/id/ENSRNOT00000044226.5" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000041380.4", "url": "https://www.ensembl.org/id/ENSRNOP00000041380.4" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 10, "end_pos": 10, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJN4", "url": "https://www.uniprot.org/uniprot/A0A096MJN4" } ], "site_lbl": "Ser10" }, { "start_pos": 170, "end_pos": 170, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "A0A096MJN4", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A0A096MJN4" } ], "site_lbl": "Thr170" }, { "start_pos": 306, "end_pos": 306, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJN4", "url": "https://www.uniprot.org/uniprot/A0A096MJN4" }, { "database": "iPTMnet", "id": "A0A096MJN4", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A0A096MJN4" } ], "site_lbl": "Ser306" }, { "start_pos": 413, "end_pos": 413, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJN4", "url": "https://www.uniprot.org/uniprot/A0A096MJN4" } ], "site_lbl": "Ser413" }, { "start_pos": 415, "end_pos": 415, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJN4", "url": "https://www.uniprot.org/uniprot/A0A096MJN4" } ], "site_lbl": "Thr415" }, { "start_pos": 49, "end_pos": 49, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJN4", "url": "https://www.uniprot.org/uniprot/A0A096MJN4" } ], "site_lbl": "Ser49" }, { "start_pos": 98, "end_pos": 98, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJN4", "url": "https://www.uniprot.org/uniprot/A0A096MJN4" } ], "site_lbl": "Ser98" }, { "start_pos": 99, "end_pos": 99, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJN4", "url": "https://www.uniprot.org/uniprot/A0A096MJN4" } ], "site_lbl": "Ser99" } ], "glycation": [], "keywords": [], "publication": [ { "title": "The Down syndrome candidate dual-specificity tyrosine phosphorylation-regulated kinase 1A phosphorylates the neurodegeneration-related septin 4.", "journal": "Neuroscience", "date": "2008", "authors": "Sitz JH, Baumgartel K, Hammerle B, Papadopoulos C, Hekerman P, Tejedor FJ, Becker W, Lutz B", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJN4", "url": "https://www.uniprot.org/uniprot/A0A096MJN4" } ], "reference": [ { "type": "PubMed", "id": "18938227", "url": "https://glygen.org/publication/PubMed/18938227" } ] }, { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "journal": "Nat. Commun.", "date": "2012", "authors": "Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJN4", "url": "https://www.uniprot.org/uniprot/A0A096MJN4" } ], "reference": [ { "type": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" } ] } ], "pathway": [ { "id": "R-RNO-111457", "name": "Release of apoptotic factors from the mitochondria", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-111457", "resource": "Reactome", "description": "Release of apoptotic factors from the mitochondria" }, { "id": "R-RNO-111469", "name": "SMAC, XIAP-regulated apoptotic response", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-111469", "resource": "Reactome", "description": "SMAC, XIAP-regulated apoptotic response" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A3Q1MXU1-1", "protein_name": "Septin-4", "gene_name": "SEPTIN4", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MDRSLGRQGGSVPEERAEAGIKRFLEDSDDAELNKFVTDFPGSETYHPPEAKTLVPRPQIQEPRPQASDLCQDDLEFKPPSWPQPSDSQQYFSASAPLSPSARPRSPWGKLDPYDSSEDDKEYVGFATLPNQVHRKSVKKGFDFTLMVAGESGLGKSTLVNSLFLTDLYRDRKLLSAEERIMQTVEITKHAVDIEEKGVKLRLTIVDTPGFGDAVNNTECWKPVAEYIDQQFEQYFRDESGLNRKNIQDNRVHCCLYFISPFGHGLRPLDVEFMKALHQRVNIVPILAKADTLTPPEVERKKRKIREEIEHFGIKVYQFPDCDSDEDEDFKSQDLALKESIPFAVIGSNTVVEARGRRVRGRLYPWGIVEVENPGHCDFVKLRTMLVRTHMQDLKDVTRETHYENYRAQCIQSMTRLVVKERNRNKLTLESGTDFPLPAVPPGTDPETERLIREKDEELRRMQEMLHKIQRQMKETH", "length": 477 }, "evidence": [ { "id": "A0A096MJN4", "url": "https://omabrowser.org/oma/group/A0A096MJN4/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "F1RRN6-1", "protein_name": "Septin-4", "gene_name": "SEPTIN4", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDRSLGWQGSSVPEDRTEAGIKRFLEDSDNPELNKFVKDFPGSESYHQPEAKTWVSRPQILEPRPQASDLCQDDLEFRPPSWPQPSDSQQFFSASAPLSPSARPRSPWGKLDPYDSSEDDKEYVGFATLPNQVHRKSVKKGFDFTLMVAGESGLGKSTLINSLFLTDLYRDRKLLSAEERIMQTVEITKHAVDIEEKGVKLRLTIVDTPGFGDAVNNTECWKPVAEYIDQQFEQYFRDESGLNRKNIQDNRVHCCLYFISPFGHGLRPLDVEFMKALHQRVNIVPILAKADTLTPPEVERKKRKIREEIEHFGIKVYQFPDCDSDEDEDFKLQDQALKESIPFAVIGSNTVVEARGRRVRGRLYPWGIVEVENPGHCDFVKLRTMLVRTHMQDLKDVTRETHYENYRAQCIQSMTRLVVKERNRNKLTRESGTDFPIPAVPPGTDPETERLIREKDEELRRMQEMLHKIQRQMKETH", "length": 477 }, "evidence": [ { "id": "A0A096MJN4", "url": "https://omabrowser.org/oma/group/A0A096MJN4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O43236-1", "protein_name": "Septin-4", "gene_name": "SEPTIN4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDRSLGWQGNSVPEDRTEAGIKRFLEDTTDDGELSKFVKDFSGNASCHPPEAKTWASRPQVPEPRPQAPDLYDDDLEFRPPSRPQSSDNQQYFCAPAPLSPSARPRSPWGKLDPYDSSEDDKEYVGFATLPNQVHRKSVKKGFDFTLMVAGESGLGKSTLVNSLFLTDLYRDRKLLGAEERIMQTVEITKHAVDIEEKGVRLRLTIVDTPGFGDAVNNTECWKPVAEYIDQQFEQYFRDESGLNRKNIQDNRVHCCLYFISPFGHGLRPLDVEFMKALHQRVNIVPILAKADTLTPPEVDHKKRKIREEIEHFGIKIYQFPDCDSDEDEDFKLQDQALKESIPFAVIGSNTVVEARGRRVRGRLYPWGIVEVENPGHCDFVKLRTMLVRTHMQDLKDVTRETHYENYRAQCIQSMTRLVVKERNRNKLTRESGTDFPIPAVPPGTDPETEKLIREKDEELRRMQEMLHKIQKQMKENY", "length": 478 }, "evidence": [ { "id": "47567275", "url": "http://www.informatics.jax.org/homology/47567275", "database": "MGI" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P28661-1", "protein_name": "Septin-4", "gene_name": "Septin4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDHSLGWQGNSVPEDGTEAGIKHFLEDSSDDAELSKFVKDFPGSEPYHSAESKTRVARPQILEPRPQSPDLCDDDVEFRGSLWPQPSDSQQYFSAPAPLSPSSRPRSPWGKLDPYDSSEDDKEYVGFATLPNQVHRKSVKKGFDFTLMVAGESGLGKSTLVNSLFLTDLYRDRKLLGAEERIMQTVEITKHAVDIEEKGVRLRLTIVDTPGFGDAVNNTECWKPVAEYIDQQFEQYFRDESGLNRKNIQDNRVHCCLYFISPFGHGLRPLDVEFMKALHQRVNIVPILAKADTLTPPEVDRKKCKIREEIEHFGIKIYQFPDCDSDEDEDFKLQDQALKESIPFAVIGSNTVVEARGRRVRGRLYPWGIVEVENPGHCDFVKLRTMLVRTHMQDLKDVTRETHYENYRAQCIQSMTRLVVKERNRNKLTRESGTDFPIPAVPPGTDPETEKLIREKDEELRRMQEMLHKIQRQMKETH", "length": 478 }, "evidence": [ { "id": "47567275", "url": "http://www.informatics.jax.org/homology/47567275", "database": "MGI" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 16, "go_terms": [ { "name": "sperm mitochondrion organization", "id": "GO:0030382", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030382", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJN4", "url": "https://www.uniprot.org/uniprot/A0A096MJN4" } ], "pmid": "" }, { "name": "tissue morphogenesis", "id": "GO:0048729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048729", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJN4", "url": "https://www.uniprot.org/uniprot/A0A096MJN4" } ], "pmid": "" }, { "name": "negative regulation of stem cell proliferation", "id": "GO:2000647", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000647", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJN4", "url": "https://www.uniprot.org/uniprot/A0A096MJN4" } ], "pmid": "" }, { "name": "positive regulation of apoptotic process", "id": "GO:0043065", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043065", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJN4", "url": "https://www.uniprot.org/uniprot/A0A096MJN4" } ], "pmid": "" }, { "name": "neuron migration", "id": "GO:0001764", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001764", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJN4", "url": 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