{ "uniprot_canonical_ac": "A0A096MJ97-1", "uniprot_ac": "A0A096MJ97", "uniprot_id": "A0A096MJ97_RAT", "mass": { "chemical_mass": 65332.0, "monoisotopic_mass": 65332.0 }, "refseq": {}, "gene_names": [ { "name": "Heatr9", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A096MJ97", "id": "A0A096MJ97" } ], "protein_names": [ { "name": "HEAT repeat containing 9", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A096MJ97/entry#names_and_taxonomy", "id": "A0A096MJ97" } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A096MJ97", "url": "https://www.uniprot.org/uniprot/A0A096MJ97" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "gene": [ { "name": "Heatr9", "url": "https://www.uniprot.org/uniprot/A0A096MJ97", "locus": { "chromosome": "10", "start_pos": 68308579, "end_pos": 68319376, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000037100", "url": "https://www.ensembl.org/id/ENSRNOG00000037100" } ] } } ], "crossref": [ { "id": "A0A096MJ97", "url": "https://alphafold.ebi.ac.uk/entry/A0A096MJ97", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSRNOG00000037100", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000037100", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "497970", "url": "https://www.ncbi.nlm.nih.gov/gene/497970", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011989", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052873", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052873", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:497970", "url": "https://www.genome.jp/dbget-bin/www_bget?rno:497970", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MEALWQV", "url": "https://omabrowser.org/oma/group/MEALWQV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A096MJ97", "url": "https://www.orthodb.org/?gene=A0A096MJ97", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR38323", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR38323", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR38323:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR38323:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "XP_006220813", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006220813", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "1559875", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1559875", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "A0A096MJ97", "url": "https://www.uniprot.org/uniprot/A0A096MJ97", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A096MJ97-1", "url": "https://www.uniprot.org/uniprot/A0A096MJ97-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGHEKQVNFSQFPKPMFNYPWLDYRNRNKKFRKAMAPVHLPLSCYKLPKEAFPPSPECWREHPSRPNATPCLHLKKHPDLITHWSTLYDQRKERESKKMLWRRRNLTSSQLSNLHVSISKLTLKPKVERSLLDATKDPLKWQRLKELTNSLNSPQEDEQCYAAYALGNLGVNKKFVMESLQQAARTGSAKVKAEIYKALAILGCLDKSVVKALIKQLMEQKESQRLETLVVLRVALNAWAAVPKSKRPKFGNEEKLVPLLQTLIDKSLNEEESLEAALCLGFLRPSNSMVQQFLIQCLCQGSMPQRMKALRMLVKMMNVHSAAVTRAILDQLHSNVIDDRLEATQMLKTIGLEKIQAQGLEELTFDLLKKKMHNEPFQVMRQAVSETVDVLKMKPLIMKLMEEQLMSPDVTERQEAIISLGALGFRNEQVFHLLLDMLDADETKTVKKSIQETLLIWASRNPWIRNKLTNKVFFVYDVPKTVKVEPTRFQKEPESLDNLCITDFRRVKLSTLSIAKSCNKLGGKLEAPAFSFYFSKPKKEMPKATGPWEPKIRQQLRNLVLSQNRFV", "length": 567, "header": "tr|A0A096MJ97-1|A0A096MJ97_RAT Isoform 1 of HEAT repeat containing 9 OS=Rattus norvegicus OX=10116 GN=Heatr9 PE=4 SV=1 CANONICAL=A0A096MJ97-1" }, "isoforms": [ { "isoform_ac": "A0A096MJ97-1", "url": "https://www.uniprot.org/uniprotkb/A0A096MJ97/entry#A0A096MJ97-1", "sequence": { "sequence": "MGHEKQVNFSQFPKPMFNYPWLDYRNRNKKFRKAMAPVHLPLSCYKLPKEAFPPSPECWREHPSRPNATPCLHLKKHPDLITHWSTLYDQRKERESKKMLWRRRNLTSSQLSNLHVSISKLTLKPKVERSLLDATKDPLKWQRLKELTNSLNSPQEDEQCYAAYALGNLGVNKKFVMESLQQAARTGSAKVKAEIYKALAILGCLDKSVVKALIKQLMEQKESQRLETLVVLRVALNAWAAVPKSKRPKFGNEEKLVPLLQTLIDKSLNEEESLEAALCLGFLRPSNSMVQQFLIQCLCQGSMPQRMKALRMLVKMMNVHSAAVTRAILDQLHSNVIDDRLEATQMLKTIGLEKIQAQGLEELTFDLLKKKMHNEPFQVMRQAVSETVDVLKMKPLIMKLMEEQLMSPDVTERQEAIISLGALGFRNEQVFHLLLDMLDADETKTVKKSIQETLLIWASRNPWIRNKLTNKVFFVYDVPKTVKVEPTRFQKEPESLDNLCITDFRRVKLSTLSIAKSCNKLGGKLEAPAFSFYFSKPKKEMPKATGPWEPKIRQQLRNLVLSQNRFV", "length": 567, "header": "tr|A0A096MJ97-1|A0A096MJ97_RAT Isoform 1 of HEAT repeat containing 9 OS=Rattus norvegicus OX=10116 GN=Heatr9 PE=4 SV=1 CANONICAL=A0A096MJ97-1" }, "locus": { "chromosome": "10", "start_pos": 68318733, "end_pos": 68309219, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000077035.2", "url": "https://www.ensembl.org/id/ENSRNOT00000077035.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000068047.1", "url": "https://www.ensembl.org/id/ENSRNOP00000068047.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool": "isoglyp", "mining_tool": "", "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "start_pos": 325, "start_aa": "T", "end_pos": 325, "end_aa": "T", "residue": "Thr", "site_lbl": "Thr325", "evidence": [ { "id": "GLY_001157", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001157" } ], "filter_code": "00000000000000001000.00000000001000.1.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "rno:497970", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?rno:497970", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A2RTY3-1", "protein_name": "Protein HEATR9", "gene_name": "HEATR9", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAYEKSTDISDVSRSMFLYPWLEYPDKTKELRKAMAPVHLPLSCYQMPKEEFPPSPECWRQHPSKPNSVPYCYFKKPEIYTHWHDLYDQREEREAEKMLRKMRDDCRYIKEVHQTHIKMFHLPMSKLTIKSEMRSRPLEPTQDPLKWQRLRELTKSLESPREDEQFYAAQALGCLRISDKFVMEALQQVAQTGPEKVKYEAYRTLAILGCLNKHVIRALIKQLKEKNEGQRMETLTGLRMALNSWAAVSKDKRTQVGDEGKLVPVLQTLIKKSSSEASLEAALCLGFLRPCSNMVQEFLLQCLCQGLKTQRMKALRMLVKVMHVHSAPVIKAILDQLCSSSVLEDRFEATQMLKTIGLEQIQAQGLEELTFNLLRRKTHNEPFLAVRQAVAQTVEELKLKPTMMNLVEAQLMNPDATARQEAVISLGVLGIRSPQVFHLLLDLLDAENHQAVKKSLQETLILCASIDPWIQNKLKNKVLSVYEAPKTNVKAEPTRFQKEPENPEELTIQDFRLAKLNPLFIAKSITKVGQKKTPAFPPCCSKPRKHRPQVIGPWQPRIKKQLRVLAEIAK", "length": 570 }, "evidence": [ { "id": "47573882", "url": "http://www.informatics.jax.org/homology/47573882", "database": "MGI" }, { "id": "A0A096MJ97", "url": "https://omabrowser.org/oma/group/A0A096MJ97/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q5QNV8-1", "protein_name": "Protein HEATR9", "gene_name": "Heatr9", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MESQEKQADFFQIPKSMDYRNRNKKFRKAMAPVHLPLSCYKVPKEAFPPSPECWRVHPSRPNATPCLHLDKKPDLFTHWRTLNEQRKERESKSLFWKRRNFPRYFKDSAQMPNLHVSISKLTLKPKEGPGLLDPTKDPLKWQRLKELTNGLNSPQEDEQCYAAYALGHLGISNKFVMEALWQVAQTGSTKVKNEAYKSLASLGCLDKSVIKAFIKQLMEHKESQRLETLVGLRVALNSWAAMPKNKKPEVPYEEKLVLLLQNLIYKPLNEESLEAALCLGFLRPSNSIVQQFLLQCLSKGSMSQRMKALRMLVKMMNVHSAAVTRAILEQLHSNVIDDRLEATQMLKTVGLEKIQAQGLVKLTFDLLKRKMYSEPFQVIRQAVSETVDVLKMKPLIMKLMEAQLMSPDVSDRQEAIISLGALGIRNEKVFHLLLDMLDAEETKSVKKSIQETLLVWASRNPWIQNKLTNKVFFVYDIPKAVKTEHTRFRKKPESPDDLCITDFRRAKLNPLFITKAYNKLGEKLEAPAFSFYFSKPKKQRPQATGPWEPKIREQLRNMVLPQNRFLFWL", "length": 569 }, "evidence": [ { "id": "47573882", "url": "http://www.informatics.jax.org/homology/47573882", "database": "MGI" }, { "id": "A0A096MJ97", "url": "https://omabrowser.org/oma/group/A0A096MJ97/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "hematopoietic progenitor cell differentiation", "id": "GO:0002244", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002244", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJ97", "url": "https://www.uniprot.org/uniprot/A0A096MJ97" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 105, "end_pos": 107, "annotation": "n_glycosylation_sequon" }, { "start_pos": 67, "end_pos": 69, "annotation": "n_glycosylation_sequon" }, { "start_pos": 8, "end_pos": 10, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A096MJ97-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 567, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A096MJ97-F1.pdb" } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 325 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 105, "end_pos": 107 }, { "start_pos": 67, "end_pos": 69 }, { "start_pos": 8, "end_pos": 10 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "prediction_tool", "mining_tool", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "prediction_tool", "mining_tool", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }