{ "uniprot_canonical_ac": "A0A059NTB8-1", "uniprot_ac": "A0A059NTB8", "uniprot_id": "A0A059NTB8_PIG", "mass": { "chemical_mass": 51503.0, "monoisotopic_mass": 51503.0 }, "refseq": { "ac": "NP_001191830", "name": "bone morphogenetic protein 5", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001191830" }, "gene_names": [ { "name": "BMP5", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A059NTB8", "id": "A0A059NTB8" }, { "name": "BMP5", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001191830", "id": "NP_001191830" } ], "protein_names": [ { "name": "Bone morphogenetic protein 5", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A059NTB8/entry#names_and_taxonomy", "id": "A0A059NTB8" }, { "name": "bone morphogenetic protein 5", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001191830", "id": "NP_001191830" } ], "function": [ { "annotation": "Genetic association studies: SNP 131C>T in 3' untranslated region is associated with fatness traits; CC pigs have thinner back fatness & heavier hams than TC pigs; CC pigs have higher fat percentage & lower lean meat percentage than TT pigs", "evidence": [ { "database": "RefSeq", "id": "NP_001191830", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001191830" }, { "database": "PubMed", "id": "21093991", "url": "https://glygen.org/publication/PubMed/21093991" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Sus scrofa", "taxid": 9823, "evidence": [ { "database": "UniProtKB", "id": "A0A059NTB8", "url": "https://www.uniprot.org/uniprot/A0A059NTB8" } ], "common_name": "Pig", "glygen_name": "Pig", "reference_species": "Sus scrofa [9823]" } ], "gene": [ { "name": "BMP5", "url": "https://www.uniprot.org/uniprot/A0A059NTB8", "locus": { "chromosome": "7", "start_pos": 25470470, "end_pos": 25344822, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSSSCG00000001478", "url": "https://www.ensembl.org/id/ENSSSCG00000001478" } ] } } ], "crossref": [ { "id": "ENSSSCG00000001478", "url": "https://bgee.org/?page=gene&gene_id=ENSSSCG00000001478", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd19395", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19395", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100151964", "url": "https://www.ncbi.nlm.nih.gov/gene/100151964", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001111", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001111", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001839", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001839", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015615", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015615", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017948", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017948", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029034", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029034", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "ssc:100151964", "url": "https://www.genome.jp/dbget-bin/www_bget?ssc:100151964", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GYPRRTQ", "url": "https://omabrowser.org/oma/group/GYPRRTQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A059NTB8", "url": "https://www.orthodb.org/?gene=A0A059NTB8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11848", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11848", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11848:SF139", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11848:SF139", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00019", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00019", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00688", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00688", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "NP_001191830", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001191830", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A059NTB8", "url": "https://www.uniprot.org/uniprot/A0A059NTB8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A059NTB8-1", "url": "https://www.uniprot.org/uniprot/A0A059NTB8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MHLTVFLLRGIVGFLWSCWVLVGYAKGGLGDNHVHSSFIYRRLRNHERREIQREILSILGLPHRPRPFSPGKQASSAPLFMLDLYNAMASEENPEEPEYSVRASLAGETRGARKGSPASPNGYPRRIQLSRTTPLTTQSPPLASLHDANFLNDADMVMSFVNLVERDKDFSHQRRHYKEFRFDLTQIPHGEAVTAAEFRIYKDRSNSRFENETIKISIYQIIKEYTNRDADLFLLDTRKVQALDVGWLVFDITVTSNHWVINPQNNLGLQLCAETGDGHSISVKSAGLVGRHGPQSKQPFMVAFFKASEVLLRSVRAANKRKNQNRNKSSSHQDSSRMSSVGDYNTSEQKQACKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQTLVHLMFPDHVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRSCGCH", "length": 454, "header": "tr|A0A059NTB8-1|A0A059NTB8_PIG Isoform 1 of Bone morphogenetic protein 5 OS=Sus scrofa OX=9823 GN=BMP5 PE=2 SV=1 CANONICAL=A0A059NTB8-1" }, "isoforms": [ { "isoform_ac": "A0A059NTB8-1", "url": "https://www.uniprot.org/uniprotkb/A0A059NTB8/entry#A0A059NTB8-1", "sequence": { "sequence": "MHLTVFLLRGIVGFLWSCWVLVGYAKGGLGDNHVHSSFIYRRLRNHERREIQREILSILGLPHRPRPFSPGKQASSAPLFMLDLYNAMASEENPEEPEYSVRASLAGETRGARKGSPASPNGYPRRIQLSRTTPLTTQSPPLASLHDANFLNDADMVMSFVNLVERDKDFSHQRRHYKEFRFDLTQIPHGEAVTAAEFRIYKDRSNSRFENETIKISIYQIIKEYTNRDADLFLLDTRKVQALDVGWLVFDITVTSNHWVINPQNNLGLQLCAETGDGHSISVKSAGLVGRHGPQSKQPFMVAFFKASEVLLRSVRAANKRKNQNRNKSSSHQDSSRMSSVGDYNTSEQKQACKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQTLVHLMFPDHVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRSCGCH", "length": 454, "header": "tr|A0A059NTB8-1|A0A059NTB8_PIG Isoform 1 of Bone morphogenetic protein 5 OS=Sus scrofa OX=9823 GN=BMP5 PE=2 SV=1 CANONICAL=A0A059NTB8-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "A C/T mutation in microRNA target sites in BMP5 gene is potentially associated with fatness in pigs.", "journal": "Meat science", "date": "2011-03", "authors": "Shao G C, Luo L F, Jiang S W, Deng C Y, Xiong Y Z, Li F E", "evidence": [ { "database": "RefSeq", "id": "NP_001191830", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001191830" } ], "reference": [ { "type": "PubMed", "id": "21093991", "url": "https://glygen.org/publication/PubMed/21093991" } ] } ], "pathway": [ { "id": "ssc:100151964", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?ssc:100151964", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0X8P5-1", "protein_name": "Bone morphotic protein 5", "gene_name": "BMP5", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MHFIYLFFSSASCVLLTFFVLPPPPSKANLPRTRQTVGVRKCDHKQSERRLRNHERREIQREILSILGLPHRPRPFSPGKQASSAPLFMLDLYNAMTNEEDTEELEYSLKGSMAGESRGMRKGYPASPNGYSRRIQLSRMTTLATQNPPLASLHDTNFLNDADMVMSFVNLVERDKDFSHQRRHYKEFRFDLTQIPHGEAVTAAEFRIYKDRSNSRFENETIQISIYQIIKEYPNRDADLFLLDTRKAQASDVGWFVFDITVTSNHWVINPQNNLGLQLCAETGDGRSINVKSAGLIGRHGPQSKQPFMVAFFKASEVLFRSVRAANNKRKNQNRNKSSSHQESSRMPSVGDYNTSEQKQACKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQTLVHLMFPDHVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRSCGCH", "length": 463 }, "evidence": [ { "id": "A0A059NTB8", "url": "https://omabrowser.org/oma/group/A0A059NTB8/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D4A7P9-1", "protein_name": "Bone morphogenetic protein 5", "gene_name": "Bmp5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MHWTVFLLRGIVGFLWSSWVQVGYAKGGLGDNHVHSSFIYRRLRNHERREIQREILSILGLPHRPRPFSPGKQASSAPLFMLDLYNAMASEENPEESEYLVRVSLAGEAKETRKGYPASPNGYAHRLHLPPRIPLTTQSPPLASLHDTNFLNDADMVMSFVNLVERDKDFSHQRRHYKEFRFDLTQIPHGEAVTAAEFRIYKDKSNHRFENETIKISIYQIIKEYTNRDADLFLLDTRKAQALDVGWLVFDITVTSNHWVINPQNNLGLQLCAETGDGRSINVKSAGLVGRHGPQSKQPFMVAFFKASEVLLRSVRAASKRKNQNRNKSSSHQDPSRIPSAGDYNTSEQKQACKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQTLVHLMFPDHVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRSCGCH", "length": 454 }, "evidence": [ { "id": "A0A059NTB8", "url": "https://omabrowser.org/oma/group/A0A059NTB8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "E1BGS3-1", "protein_name": "Bone morphotic protein 5", "gene_name": "BMP5", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MHLTVFLLRGIVGFLWSCWVLVGSTKGSLGDNHVHSSFIYRRLRNHERREIQREILSILGLPHRPRPFSPGKQASSAPLFMLDLYNAMASEENPEELEYSVRAPLAADSRGARKGSPASPNGYPRRIQLSRASPLTTQSPPLASLHDANFLNDADMVMSFVNLVERDKDFSHQRRHYKEFRFDLTQIPQGEAVTAAEFRIYKDRSNGRFENETIKISIYQIIKEYANRDADLFLLDTRKTQALDVGWLVFDITVTSNHWVINPQNNLGLQLCAETGDGHSINVKSAGLVGRHGPQSKQPFMVAFFKASEVLLRSVRAANKRKNQNRNKSGSHQDSSRMSSVGDYNTSEQKQACKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQTLVHLMFPDHVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRSCGCH", "length": 454 }, "evidence": [ { "id": "A0A059NTB8", "url": "https://omabrowser.org/oma/group/A0A059NTB8/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "P22003-1", "protein_name": "Bone morphogenetic protein 5", "gene_name": "BMP5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MHLTVFLLKGIVGFLWSCWVLVGYAKGGLGDNHVHSSFIYRRLRNHERREIQREILSILGLPHRPRPFSPGKQASSAPLFMLDLYNAMTNEENPEESEYSVRASLAEETRGARKGYPASPNGYPRRIQLSRTTPLTTQSPPLASLHDTNFLNDADMVMSFVNLVERDKDFSHQRRHYKEFRFDLTQIPHGEAVTAAEFRIYKDRSNNRFENETIKISIYQIIKEYTNRDADLFLLDTRKAQALDVGWLVFDITVTSNHWVINPQNNLGLQLCAETGDGRSINVKSAGLVGRQGPQSKQPFMVAFFKASEVLLRSVRAANKRKNQNRNKSSSHQDSSRMSSVGDYNTSEQKQACKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQTLVHLMFPDHVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRSCGCH", "length": 454 }, "evidence": [ { "id": "A0A059NTB8", "url": "https://omabrowser.org/oma/group/A0A059NTB8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P49003-1", "protein_name": "Bone morphogenetic protein 5", "gene_name": "Bmp5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MHWTVFLLRGIVGFLWSGWVQVGYAKGGLGDNHVHSSFIYRRLRNHERREIQREILSILGLPHRPRPFSPGKQASSAPLFMLDLYNAMASEDNPEEYLVRVSLAGEAKETRKGYPASPNGYAHRLHLPPRTPLTTQSPPLASLHDTNFLNDADMVMSFVNLVERDKDFSHQRRHYKEFRFDLTQIPHGEAVTAAEFRIYKDKGNHRFENETIKISIYQIIKEYTNRDADLFLLDTRKTQALDVGWLVFDITVTSNHWVINPQNNLGLQLCAETGDGRSINVKSAGLVGRHGPQSKQPFMVAFFKASEVLLRSVRAASKRKNQNRNKSNSHQDPSRMPSAGDYNTSEQKQACKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQTLVHLMFPDHVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRSCGCH", "length": 452 }, "evidence": [ { "id": "A0A059NTB8", "url": "https://omabrowser.org/oma/group/A0A059NTB8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0A059NTB8", "url": "https://www.uniprot.org/uniprot/A0A059NTB8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 10, "go_terms": [ { "name": "negative regulation of cell population proliferation", "id": "GO:0008285", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008285", "evidence": [ { "database": "UniProtKB", "id": "A0A059NTB8", "url": "https://www.uniprot.org/uniprot/A0A059NTB8" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "A0A059NTB8", "url": "https://www.uniprot.org/uniprot/A0A059NTB8" } ], "pmid": "" }, { "name": "BMP signaling pathway", "id": "GO:0030509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030509", "evidence": [ { "database": "UniProtKB", "id": "A0A059NTB8", "url": "https://www.uniprot.org/uniprot/A0A059NTB8" } ], "pmid": "" }, { "name": "positive regulation of epithelial cell proliferation", "id": "GO:0050679", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050679", "evidence": [ { "database": "UniProtKB", "id": "A0A059NTB8", "url": "https://www.uniprot.org/uniprot/A0A059NTB8" } ], "pmid": "" }, { "name": "type B pancreatic cell development", "id": "GO:0003323", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003323", "evidence": [ { "database": "UniProtKB", "id": "A0A059NTB8", "url": "https://www.uniprot.org/uniprot/A0A059NTB8" } ], "pmid": "" }, { "name": "positive regulation of SMAD protein signal transduction", "id": "GO:0060391", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060391", "evidence": [ { "database": "UniProtKB", "id": "A0A059NTB8", "url": "https://www.uniprot.org/uniprot/A0A059NTB8" } ], "pmid": "" }, { "name": "positive regulation of dendrite development", "id": "GO:1900006", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900006", "evidence": [ { "database": "UniProtKB", "id": "A0A059NTB8", "url": "https://www.uniprot.org/uniprot/A0A059NTB8" } ], "pmid": "" }, { "name": "negative regulation of aldosterone biosynthetic process", "id": "GO:0032348", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032348", "evidence": [ { "database": "UniProtKB", "id": "A0A059NTB8", "url": "https://www.uniprot.org/uniprot/A0A059NTB8" } ], "pmid": "" }, { "name": "negative regulation of insulin-like growth factor receptor signaling pathway", "id": "GO:0043569", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043569", "evidence": [ { "database": "UniProtKB", "id": "A0A059NTB8", "url": "https://www.uniprot.org/uniprot/A0A059NTB8" } ], "pmid": "" }, { "name": "negative regulation of cortisol biosynthetic process", "id": "GO:2000065", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000065", "evidence": [ { "database": "UniProtKB", "id": "A0A059NTB8", "url": "https://www.uniprot.org/uniprot/A0A059NTB8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "cytokine activity", "id": "GO:0005125", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005125", "evidence": [ { "database": "UniProtKB", "id": "A0A059NTB8", "url": "https://www.uniprot.org/uniprot/A0A059NTB8" } ], "pmid": "" }, { "name": "growth factor activity", "id": "GO:0008083", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008083", "evidence": [ { "database": "UniProtKB", "id": "A0A059NTB8", "url": "https://www.uniprot.org/uniprot/A0A059NTB8" } ], "pmid": "" }, { "name": "BMP receptor binding", "id": "GO:0070700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070700", "evidence": [ { "database": "UniProtKB", "id": "A0A059NTB8", "url": "https://www.uniprot.org/uniprot/A0A059NTB8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 211, "end_pos": 213, "annotation": "n_glycosylation_sequon" }, { "start_pos": 327, "end_pos": 329, "annotation": "n_glycosylation_sequon" }, { "start_pos": 345, "end_pos": 347, "annotation": "n_glycosylation_sequon" }, { "start_pos": 395, "end_pos": 397, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], 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], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }