{
    "uniprot_canonical_ac": "A0A1L1RZP2-1",
    "uniprot_ac": "A0A1L1RZP2",
    "uniprot_id": "A0A1L1RZP2_CHICK",
    "mass": {
        "chemical_mass": 42505.0,
        "monoisotopic_mass": 42505.0
    },
    "refseq": {},
    "gene_names": [
        {
            "name": "OTUD3",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A0A1L1RZP2",
            "id": "A0A1L1RZP2"
        }
    ],
    "protein_names": [
        {
            "name": "ubiquitinyl hydrolase 1",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprotkb/A0A1L1RZP2/entry#names_and_taxonomy",
            "id": "A0A1L1RZP2"
        },
        {
            "name": "3.4.19.12",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprotkb/A0A1L1RZP2/entry#names_and_taxonomy",
            "id": "A0A1L1RZP2"
        }
    ],
    "function": [],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Gallus gallus",
            "taxid": 9031,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A1L1RZP2",
                    "url": "https://www.uniprot.org/uniprot/A0A1L1RZP2"
                }
            ],
            "common_name": "Chicken",
            "glygen_name": "Chicken",
            "reference_species": "Gallus gallus [9031]"
        }
    ],
    "gene": [
        {
            "name": "OTUD3",
            "url": "https://www.uniprot.org/uniprot/A0A1L1RZP2",
            "locus": {
                "chromosome": "21",
                "start_pos": 4832374,
                "end_pos": 4823348,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSGALG00010020679",
                        "url": "https://www.ensembl.org/id/ENSGALG00010020679"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "A0A1L1RZP2",
            "url": "https://alphafold.ebi.ac.uk/entry/A0A1L1RZP2",
            "database": "AlphaFoldDB",
            "categories": []
        },
        {
            "id": "ENSGALG00000043920",
            "url": "https://bgee.org/?page=gene&gene_id=ENSGALG00000043920",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd22770",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22770",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR003323",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR003323",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR038765",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR038765",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR050704",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR050704",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "TDFQILH",
            "url": "https://omabrowser.org/oma/group/TDFQILH/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "A0A1L1RZP2",
            "url": "https://www.orthodb.org/?gene=A0A1L1RZP2",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR12419",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12419",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR12419:SF7",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12419:SF7",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF02338",
            "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02338",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-GGA-5689896",
            "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-5689896",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-GGA-8948751",
            "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-8948751",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "A0A1L1RZP2",
            "url": "https://www.uniprot.org/uniprot/A0A1L1RZP2",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A1L1RZP2-1",
            "url": "https://www.uniprot.org/uniprot/A0A1L1RZP2-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MSRKQAARARPGGPKKARRPRQPTGGTAPKPSEGGGGLARQLRALGLKLREVPGDGNCLFRALGDQLEGHSRNHLRHRQETVEYMIKQREDFEPFVEDDVPFEKHVTNLAKPGTFAGNDAIVAFARNNQMNVVIHQLDAPLWQIQGTDKSNVRELHIAYRHGEHYDSVRRINDDSEAPAYLRMEMLSKNDSNKEEEMKQQKGDSEDETEIEIEAAIQEVCSATGCSDTELVSQVLKVEDYNVESAIFAIFQVQEVERISAEEQSDPQSEGQNPCASALCEDNGSGSRIFGSQSLHHHETENIKGQARSDEESRANKNLKVFKKQKKEQQRLEKKKRQEERHRQKVLANRSNCADNSRKEVDSDNQITLVKTMAALNI",
        "length": 377,
        "header": "tr|A0A1L1RZP2-1|A0A1L1RZP2_CHICK Isoform 1 of ubiquitinyl hydrolase 1  OS=Gallus gallus OX=9031 GN=OTUD3 PE=4 SV=2 CANONICAL=A0A1L1RZP2-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A1L1RZP2-1",
            "url": "https://www.uniprot.org/uniprotkb/A0A1L1RZP2/entry#A0A1L1RZP2-1",
            "sequence": {
                "sequence": "MSRKQAARARPGGPKKARRPRQPTGGTAPKPSEGGGGLARQLRALGLKLREVPGDGNCLFRALGDQLEGHSRNHLRHRQETVEYMIKQREDFEPFVEDDVPFEKHVTNLAKPGTFAGNDAIVAFARNNQMNVVIHQLDAPLWQIQGTDKSNVRELHIAYRHGEHYDSVRRINDDSEAPAYLRMEMLSKNDSNKEEEMKQQKGDSEDETEIEIEAAIQEVCSATGCSDTELVSQVLKVEDYNVESAIFAIFQVQEVERISAEEQSDPQSEGQNPCASALCEDNGSGSRIFGSQSLHHHETENIKGQARSDEESRANKNLKVFKKQKKEQQRLEKKKRQEERHRQKVLANRSNCADNSRKEVDSDNQITLVKTMAALNI",
                "length": 377,
                "header": "tr|A0A1L1RZP2-1|A0A1L1RZP2_CHICK Isoform 1 of ubiquitinyl hydrolase 1  OS=Gallus gallus OX=9031 GN=OTUD3 PE=4 SV=2 CANONICAL=A0A1L1RZP2-1"
            },
            "locus": {
                "chromosome": "21",
                "start_pos": 4830791,
                "end_pos": 4823352,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSGALT00010049955.1",
                        "url": "https://www.ensembl.org/id/ENSGALT00010049955.1"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSGALP00010029507.1",
                        "url": "https://www.ensembl.org/id/ENSGALP00010029507.1"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [
        "enzyme"
    ],
    "publication": [],
    "pathway": [
        {
            "id": "R-GGA-5689896",
            "name": "Ovarian tumor domain proteases",
            "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-5689896",
            "resource": "Reactome",
            "description": "Ovarian tumor domain proteases"
        },
        {
            "id": "R-GGA-8948751",
            "name": "Regulation of PTEN stability and activity",
            "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-8948751",
            "resource": "Reactome",
            "description": "Regulation of PTEN stability and activity"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "A0A480EGF6-1",
            "protein_name": "ubiquitinyl hydrolase 1",
            "gene_name": "OTUD3",
            "tax_id": 9823,
            "organism": "Sus scrofa",
            "sequence": {
                "sequence": "MSRKQAAKSRPGSGSRKAEAERKRDERAARRALAKERRNRPESGGGGGCEEEFVSFANQLQALGLKLREVPGDGNCLFRALGDQLEGHSRNHLRHRQETVDYMIKQREDFEPFVEDDIPFEKHVASLAKPGTFAGNDAIVAFARNHQLNVVIHQLNAPLWQIRGTDKSNVRELHIAYRYGEHYDSVRRINDNSEAPAHLQTDFQMLHQDESNKREKIKTKGIDFEDDLRDEVEDAVQKVCNATGCSDFNLIVQNLEAENYNIESAIIAMLQMNQGKRNNAEENLESSGRVLKQCGPLWEEGGSGTRICGNQGLNEGRTENNKARASPSEENKANKNQLPKVTNKQRREQQRLEKKKRQEERHRHKALESRSSHRDNNRSEAEPGAQVTLVKTFAALNI",
                "length": 398
            },
            "evidence": [
                {
                    "id": "A0A1L1RZP2",
                    "url": "https://omabrowser.org/oma/group/A0A1L1RZP2/",
                    "database": "OMA"
                }
            ],
            "glygen_name": "Pig",
            "common_name": "Pig"
        },
        {
            "uniprot_canonical_ac": "B1AZ99-1",
            "protein_name": "OTU domain-containing protein 3",
            "gene_name": "Otud3",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MSRKQAAKSRPGSGGRRAEAERKRDERAARRALAKERRNRPDPGGSGCEEEFVSFANQLQALGLKLREVPGDGNCLFRALGDQLEGHSRNHLKHRQETVDYMIRQREDFEPFVEDDIPFEKHVASLSKPGTFAGNDAIVAFARNHQLNVVIHQLNAPLWQIRGTDKGSTRELHIAYRYGEHYDSVRRINDNSEAPAHLLTDFQMLHQDGANKKEKMKTKGVDVKDGLRDDVEDAVHKVGSATGCTDFNLIVQNLEAENYNIKSAITALLQVNQGTGNDAEENHEPGDRVKQRGPSREEAGSGRRLSGNQGRNEGRMETSEARASPAEESKAHKSQLPKVTNKQRREQQRLEKKKRQEERHRLKALENRNGSRDTGRSEADMNTQVTLVKTFAALNI",
                "length": 396
            },
            "evidence": [
                {
                    "id": "A0A1L1RZP2",
                    "url": "https://omabrowser.org/oma/group/A0A1L1RZP2/",
                    "database": "OMA"
                }
            ],
            "glygen_name": "Mouse",
            "common_name": "Mouse"
        },
        {
            "uniprot_canonical_ac": "D4A7M3-1",
            "protein_name": "ubiquitinyl hydrolase 1",
            "gene_name": "Otud3",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MSRKQAAKSRPGSGGRRAEAERKRDERAARRALAKERRNRPEPGSSGCEEEFVSFANQLQALGLKLREVPGDGNCLFRALGDQLEGHSRNHLKHRQETVDYMIRQREDFEPFVEDDIPFEKHVASLAKPGTFAGNDAIVAFARNHQLNVVIHQLNAPLWQIRGTDKSSARELHIAYRYGEHYDSVRRINDNSEAPAHLLTDFQMLHQDRTNKKEKMKTQGDSLRDDMEDAVQKAGSATGCTDSNLIVQNLEAESHTIEPSVTALLQMNQGTSKDAEKSLEPGDRVKQRGPSCEEAGGGSRLSGNQGRNEGRVETSEARASPGEESRARKKSQCPKVTNKQRREQQRLEKKKRQEERHRLKALENRNGSRDRGREADVNTQVTLVKTFAALNI",
                "length": 392
            },
            "evidence": [
                {
                    "id": "A0A1L1RZP2",
                    "url": "https://omabrowser.org/oma/group/A0A1L1RZP2/",
                    "database": "OMA"
                }
            ],
            "glygen_name": "Rat",
            "common_name": "Rat"
        },
        {
            "uniprot_canonical_ac": "E1BDM3-1",
            "protein_name": "ubiquitinyl hydrolase 1",
            "gene_name": "OTUD3",
            "tax_id": 9913,
            "organism": "Bos taurus",
            "sequence": {
                "sequence": "MSRKQAAKGRPGSGSRRAEAERKRDERAARRALAKERRNRPESGGGGACEEEFVSFANQLQALGLKLREVPGDGNCLFRALGDQLEGHSRNHVKHRQETVDYMIKQREDFEPFVEDDIPFEKHVASLAKPGTFAGNDAIVAFARNHQLNVVIHQLNAPLWQIRGTDRSNGRELHIAYRHGEHYDSVRRLNDNSEAPARLQTEFQMLHQDESNKREKSKAKGVDSEDDLRDEVEDAVQKVCNATGCSDFSLIVQNLEAENYNIESAIIAMLQMNPGRRNNAEEKLEPSGGVLTQCGPLWEEGGSGTRIFGNQGVNEGRTESSKARASPAEENTANKNQVPKVTNKQRREQQRLEKKKRQEERHRHKALESRSHRGSNRSEWKVEGCVPGFPVRPSFYRTKLNPQNHSLS",
                "length": 408
            },
            "evidence": [
                {
                    "id": "A0A1L1RZP2",
                    "url": "https://omabrowser.org/oma/group/A0A1L1RZP2/",
                    "database": "OMA"
                }
            ],
            "glygen_name": "Bovine",
            "common_name": "Bovine"
        },
        {
            "uniprot_canonical_ac": "Q5T2D3-1",
            "protein_name": "OTU domain-containing protein 3",
            "gene_name": "OTUD3",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MSRKQAAKSRPGSGSRKAEAERKRDERAARRALAKERRNRPESGGGGGCEEEFVSFANQLQALGLKLREVPGDGNCLFRALGDQLEGHSRNHLKHRQETVDYMIKQREDFEPFVEDDIPFEKHVASLAKPGTFAGNDAIVAFARNHQLNVVIHQLNAPLWQIRGTEKSSVRELHIAYRYGEHYDSVRRINDNSEAPAHLQTDFQMLHQDESNKREKIKTKGMDSEDDLRDEVEDAVQKVCNATGCSDFNLIVQNLEAENYNIESAIIAVLRMNQGKRNNAEENLEPSGRVLKQCGPLWEEGGSGARIFGNQGLNEGRTENNKAQASPSEENKANKNQLAKVTNKQRREQQWMEKKKRQEERHRHKALESRGSHRDNNRSEAEANTQVTLVKTFAALNI",
                "length": 398
            },
            "evidence": [
                {
                    "id": "A0A1L1RZP2",
                    "url": "https://omabrowser.org/oma/group/A0A1L1RZP2/",
                    "database": "OMA"
                }
            ],
            "glygen_name": "Human",
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Cellular Component",
                "total": 2,
                "go_terms": [
                    {
                        "name": "nucleus",
                        "id": "GO:0005634",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1L1RZP2",
                                "url": "https://www.uniprot.org/uniprot/A0A1L1RZP2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytoplasm",
                        "id": "GO:0005737",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1L1RZP2",
                                "url": "https://www.uniprot.org/uniprot/A0A1L1RZP2"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 3,
                "go_terms": [
                    {
                        "name": "protein stabilization",
                        "id": "GO:0050821",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050821",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1L1RZP2",
                                "url": "https://www.uniprot.org/uniprot/A0A1L1RZP2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cellular response to nutrient levels",
                        "id": "GO:0031669",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031669",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1L1RZP2",
                                "url": "https://www.uniprot.org/uniprot/A0A1L1RZP2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction",
                        "id": "GO:0051898",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051898",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1L1RZP2",
                                "url": "https://www.uniprot.org/uniprot/A0A1L1RZP2"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 1,
                "go_terms": [
                    {
                        "name": "cysteine-type deubiquitinase activity",
                        "id": "GO:0004843",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004843",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1L1RZP2",
                                "url": "https://www.uniprot.org/uniprot/A0A1L1RZP2"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 189,
            "end_pos": 191,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 282,
            "end_pos": 284,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 348,
            "end_pos": 350,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [
        {
            "id": "R-GGA-6807206",
            "name": "USP13 and OTUD3 deubiquitinate PTEN",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol",
            "input_participant_list": [],
            "output_participant_list": [
                "R-GGA-199420"
            ],
            "enzyme_list": [
                "A0A1L1RZP2-1"
            ],
            "evidence": [
                {
                    "id": "R-GGA-6807206",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-6807206"
                }
            ]
        },
        {
            "id": "R-GGA-8873946",
            "name": "OTUD3 deubiquitinates PTEN",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol",
            "input_participant_list": [
                "R-GGA-8874327"
            ],
            "output_participant_list": [],
            "enzyme_list": [
                "A0A1L1RZP2-1"
            ],
            "evidence": [
                {
                    "id": "R-GGA-8873946",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-8873946"
                }
            ]
        }
    ],
    "reaction_participants": [
        {
            "participant_id": "R-GGA-199420",
            "participant_name": "PTEN [cytosol]",
            "crossref": [
                {
                    "id": "F1NT98",
                    "database": "UniProt",
                    "url": ""
                }
            ]
        },
        {
            "participant_id": "R-GGA-8874327",
            "participant_name": "K48polyUb-PTEN [cytosol]",
            "crossref": [
                {
                    "id": "F1NT98",
                    "database": "UniProt",
                    "url": ""
                }
            ]
        }
    ],
    "reaction_enzymes": [
        {
            "uniprot_ac": "A0A1L1RZP2",
            "gene_name": "OTUD3",
            "activity": [
                {
                    "ec_number": "3.4.19.12",
                    "activity": "Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).",
                    "evidence": [
                        {
                            "id": "A0A1L1RZP2",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/A0A1L1RZP2"
                        }
                    ]
                },
                {
                    "ec_number": "3.4.19.12",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "A0A1L1RZP2",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/A0A1L1RZP2"
                        }
                    ]
                }
            ]
        }
    ],
    "biomarkers": [],
    "structures": [
        {
            "pdb_id": "AF-A0A1L1RZP2-F1",
            "pdb_chain": "global",
            "start_pos": 1,
            "end_pos": 377,
            "overlap": "1.0",
            "method": "AlphaFold",
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