{
    "biomarker_id": "AA4775-2",
    "biomarker_canonical_id": "AA4775",
    "condition": {
        "recommended_name": {
            "id": "DOID:0080600",
            "resource": "Disease Ontology",
            "url": "http://disease-ontology.org/term/DOID:0080600",
            "name": "COVID-19",
            "description": "A Coronavirus infectious disease that is characterized by fever, cough and shortness of breath and that has_material_basis_in SARS-CoV-2."
        },
        "synonyms": [
            {
                "id": "DOID:0080600",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0080600",
                "name": "2019 Novel Coronavirus (2019-nCoV)",
                "description": ""
            },
            {
                "id": "DOID:0080600",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0080600",
                "name": "2019-nCoV infection",
                "description": ""
            },
            {
                "id": "DOID:0080600",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0080600",
                "name": "Wuhan coronavirus infection",
                "description": ""
            },
            {
                "id": "DOID:0080600",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0080600",
                "name": "Wuhan seafood market pneumonia virus infection",
                "description": ""
            },
            {
                "id": "DOID:0080600",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0080600",
                "name": "COVID19",
                "description": ""
            },
            {
                "id": "DOID:0080600",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0080600",
                "name": "SARS-CoV-2 infection",
                "description": ""
            }
        ],
        "id": "DOID:0080600"
    },
    "biomarker_component": [
        {
            "biomarker": "increased ENO2 level",
            "assessed_biomarker_entity_id": "P09104-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Neuron-specific enolase",
                "synonyms": [
                    {
                        "synonym": "Neuron-specific enolase"
                    },
                    {
                        "synonym": "NSE"
                    },
                    {
                        "synonym": "Enolase 2"
                    },
                    {
                        "synonym": "Neural enolase"
                    },
                    {
                        "synonym": "2-phospho-D-glycerate hydro-lyase"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "blood",
                    "namespace": "UBERON",
                    "id": "0000178",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0000178",
                    "loinc_code": "19193-2"
                }
            ],
            "evidence_source": [
                {
                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                },
                {
                    "id": "32504736",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/32504736",
                    "tags": [
                        "biomarker",
                        " assessed_biomarker_entity",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "In short, we concluded that the concentrations of tumor biomarkers of CEA, CYFRA21-1, NSE, SCCA, ProGRP were elevated in COVID-19 patients, and that CEA, CYFRA21-1, SCCA could predicte the clinical outcome of COVID-19 patients."
                        }
                    ]
                },
                {
                    "id": "32347972",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/32347972",
                    "tags": [
                        "biomarker",
                        " assessed_biomarker_entity",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "Presence of elevated NSE levels shown as predictor of COVID-19 severity."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "prognostic"
        }
    ],
    "evidence_source": [
        {
            "id": "GLY_000625",
            "database": "GlyGen",
            "url": "https://data.glygen.org/GLY_000625"
        },
        {
            "id": "32504736",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/32504736",
            "tags": [
                "condition",
                " best_biomarker_role"
            ],
            "evidence_list": [
                {
                    "evidence": "In short, we concluded that the concentrations of tumor biomarkers of CEA, CYFRA21-1, NSE, SCCA, ProGRP were elevated in COVID-19 patients, and that CEA, CYFRA21-1, SCCA could predicte the clinical outcome of COVID-19 patients."
                }
            ]
        },
        {
            "id": "32347972",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/32347972",
            "tags": [
                "condition",
                " best_biomarker_role"
            ],
            "evidence_list": [
                {
                    "evidence": "Presence of elevated NSE levels shown as predictor of COVID-19 severity."
                }
            ]
        }
    ],
    "citation": [
        {
            "title": "Tumor biomarkers predict clinical outcome of COVID-19 patients.",
            "journal": "The Journal of infection",
            "authors": "He B, Zhong A, Wu Q, Liu X, Lin J, Chen C, He Y, Guo Y, Zhang M, Zhu P, Wu J, Wang C, Wang S, Xia X",
            "date": "2020",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "32504736",
                    "url": "https://glygen.org/publication/PubMed/32504736"
                }
            ],
            "evidence": [
                {
                    "id": "AA4721-2",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/AA4775-2"
                }
            ]
        },
        {
            "title": "Elevations of serum cancer biomarkers correlate with severity of COVID-19.",
            "journal": "Journal of medical virology",
            "authors": "Wei X, Su J, Yang K, Wei J, Wan H, Cao X, Tan W, Wang H",
            "date": "2020",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "32347972",
                    "url": "https://glygen.org/publication/PubMed/32347972"
                }
            ],
            "evidence": [
                {
                    "id": "AA4775-2",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/AA4775-2"
                }
            ]
        }
    ],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
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                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
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}