{
    "title": "Mechanism of action and in vivo role of platelet-derived growth factor.",
    "journal": "Physiological reviews",
    "date": "1999",
    "authors": "Heldin CH, Westermark B",
    "reference": {
        "type": "PubMed",
        "id": "10508235",
        "url": "https://pubmed.ncbi.nlm.nih.gov/10508235"
    },
    "referenced_glycans": [],
    "referenced_proteins": [
        {
            "uniprot_canonical_ac": "P20849-1",
            "protein_name": "Collagen alpha-1(IX) chain",
            "gene_name": "COL9A1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "O00459-1",
            "protein_name": "Phosphatidylinositol 3-kinase regulatory subunit beta",
            "gene_name": "PIK3R2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P01127-1",
            "protein_name": "Platelet-derived growth factor subunit B",
            "gene_name": "PDGFB",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P02462-1",
            "protein_name": "Collagen alpha-1(IV) chain",
            "gene_name": "COL4A1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P25940-1",
            "protein_name": "Collagen alpha-3(V) chain",
            "gene_name": "COL5A3",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P09619-1",
            "protein_name": "Platelet-derived growth factor receptor beta",
            "gene_name": "PDGFRB",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P01112-1",
            "protein_name": "GTPase HRas",
            "gene_name": "HRAS",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P19174-1",
            "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1",
            "gene_name": "PLCG1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "A8TX70-1",
            "protein_name": "Collagen alpha-5(VI) chain",
            "gene_name": "COL6A5",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q05209-1",
            "protein_name": "Tyrosine-protein phosphatase non-receptor type 12",
            "gene_name": "PTPN12",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P12111-1",
            "protein_name": "Collagen alpha-3(VI) chain",
            "gene_name": "COL6A3",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P16333-1",
            "protein_name": "SH2/SH3 adapter protein NCK1",
            "gene_name": "NCK1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q14451-1",
            "protein_name": "Growth factor receptor-bound protein 7",
            "gene_name": "GRB7",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P53420-1",
            "protein_name": "Collagen alpha-4(IV) chain",
            "gene_name": "COL4A4",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P35442-1",
            "protein_name": "Thrombospondin-2",
            "gene_name": "THBS2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q14050-1",
            "protein_name": "Collagen alpha-3(IX) chain",
            "gene_name": "COL9A3",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P46108-1",
            "protein_name": "Adapter molecule crk",
            "gene_name": "CRK",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P27986-1",
            "protein_name": "Phosphatidylinositol 3-kinase regulatory subunit alpha",
            "gene_name": "PIK3R1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q01955-1",
            "protein_name": "Collagen alpha-3(IV) chain",
            "gene_name": "COL4A3",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P07996-1",
            "protein_name": "Thrombospondin-1",
            "gene_name": "THBS1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P51692-1",
            "protein_name": "Signal transducer and activator of transcription 5B",
            "gene_name": "STAT5B",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P00750-1",
            "protein_name": "Tissue-type plasminogen activator",
            "gene_name": "PLAT",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P08572-1",
            "protein_name": "Collagen alpha-2(IV) chain",
            "gene_name": "COL4A2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P42338-1",
            "protein_name": "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform",
            "gene_name": "PIK3CB",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P46109-1",
            "protein_name": "Crk-like protein",
            "gene_name": "CRKL",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P42336-1",
            "protein_name": "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform",
            "gene_name": "PIK3CA",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P42229-1",
            "protein_name": "Signal transducer and activator of transcription 5A",
            "gene_name": "STAT5A",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P20908-1",
            "protein_name": "Collagen alpha-1(V) chain",
            "gene_name": "COL5A1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P35443-1",
            "protein_name": "Thrombospondin-4",
            "gene_name": "THBS4",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P42224-1",
            "protein_name": "Signal transducer and activator of transcription 1-alpha/beta",
            "gene_name": "STAT1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P56945-1",
            "protein_name": "Breast cancer anti-estrogen resistance protein 1",
            "gene_name": "BCAR1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P16234-1",
            "protein_name": "Platelet-derived growth factor receptor alpha",
            "gene_name": "PDGFRA",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q06124-2",
            "protein_name": "Tyrosine-protein phosphatase non-receptor type 11",
            "gene_name": "PTPN11",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P00747-1",
            "protein_name": "Plasminogen",
            "gene_name": "PLG",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P02458-2",
            "protein_name": "Collagen alpha-1(II) chain",
            "gene_name": "COL2A1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P49746-1",
            "protein_name": "Thrombospondin-3",
            "gene_name": "THBS3",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "A6NMZ7-1",
            "protein_name": "Collagen alpha-6(VI) chain",
            "gene_name": "COL6A6",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P10451-1",
            "protein_name": "Osteopontin",
            "gene_name": "SPP1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q07889-1",
            "protein_name": "Son of sevenless homolog 1",
            "gene_name": "SOS1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P40763-1",
            "protein_name": "Signal transducer and activator of transcription 3",
            "gene_name": "STAT3",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P05997-1",
            "protein_name": "Collagen alpha-2(V) chain",
            "gene_name": "COL5A2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9GZP0-1",
            "protein_name": "Platelet-derived growth factor D",
            "gene_name": "PDGFD",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P42226-1",
            "protein_name": "Signal transducer and activator of transcription 6",
            "gene_name": "STAT6",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P20936-1",
            "protein_name": "Ras GTPase-activating protein 1",
            "gene_name": "RASA1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P12931-1",
            "protein_name": "Proto-oncogene tyrosine-protein kinase Src",
            "gene_name": "SRC",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P12109-1",
            "protein_name": "Collagen alpha-1(VI) chain",
            "gene_name": "COL6A1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q14055-1",
            "protein_name": "Collagen alpha-2(IX) chain",
            "gene_name": "COL9A2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P01111-1",
            "protein_name": "GTPase NRas",
            "gene_name": "NRAS",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P02461-1",
            "protein_name": "Collagen alpha-1(III) chain",
            "gene_name": "COL3A1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P29400-1",
            "protein_name": "Collagen alpha-5(IV) chain",
            "gene_name": "COL4A5",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P12110-1",
            "protein_name": "Collagen alpha-2(VI) chain",
            "gene_name": "COL6A2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q13905-1",
            "protein_name": "Rap guanine nucleotide exchange factor 1",
            "gene_name": "RAPGEF1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P09958-1",
            "protein_name": "Furin",
            "gene_name": "FURIN",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "O43639-1",
            "protein_name": "Cytoplasmic protein NCK2",
            "gene_name": "NCK2",
            "tax_name": "Human"
        }
    ],
    "species": [
        {
            "name": "Homo sapiens",
            "taxid": 9606,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P20849",
                    "url": "https://www.uniprot.org/uniprot/P20849"
                }
            ],
            "common_name": "Human",
            "glygen_name": "Human",
            "reference_species": "Homo sapiens [9606]"
        }
    ],
    "record_id": "pubmed.10508235",
    "abstract": "",
    "glycosylation": [],
    "mutagenesis": [],
    "snv": [],
    "phosphorylation": [],
    "glycation": [],
    "section_stats": [
        {
            "table_id": "referenced_proteins",
            "table_stats": [
                {
                    "field": "total",
                    "count": 54
                }
            ],
            "sort_fields": [
                "uniprot_canonical_ac",
                "protein_name",
                "gene_name",
                "tax_name"
            ]
        },
        {
            "table_id": "referenced_glycans",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "phosphorylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported_with_glycan",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_predicted",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_automatic_literature_mining",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        }
    ]
}
