{
    "title": "RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination.",
    "journal": "Proceedings of the National Academy of Sciences of the United States of America",
    "date": "1999",
    "authors": "Lorick KL, Jensen JP, Fang S, Ong AM, Hatakeyama S, Weissman AM",
    "reference": {
        "type": "PubMed",
        "id": "10500182",
        "url": "https://pubmed.ncbi.nlm.nih.gov/10500182"
    },
    "referenced_glycans": [],
    "referenced_proteins": [
        {
            "uniprot_canonical_ac": "Q12986-1",
            "protein_name": "Transcriptional repressor NF-X1",
            "gene_name": "NFX1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q8WU17-1",
            "protein_name": "E3 ubiquitin-protein ligase RNF139",
            "gene_name": "RNF139",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "O00237-1",
            "protein_name": "E3 ubiquitin-protein ligase RNF103",
            "gene_name": "RNF103",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9QZR0-1",
            "protein_name": "E3 ubiquitin-protein ligase RNF25",
            "gene_name": "Rnf25",
            "tax_name": "Mouse"
        },
        {
            "uniprot_canonical_ac": "P38398-1",
            "protein_name": "Breast cancer type 1 susceptibility protein",
            "gene_name": "BRCA1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "O55176-3",
            "protein_name": "E3 ubiquitin-protein ligase Praja-1",
            "gene_name": "Pja1",
            "tax_name": "Mouse"
        },
        {
            "uniprot_canonical_ac": "Q96BH1-1",
            "protein_name": "E3 ubiquitin-protein ligase RNF25",
            "gene_name": "RNF25",
            "tax_name": "Human"
        }
    ],
    "species": [
        {
            "name": "Homo sapiens",
            "taxid": 9606,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q12986",
                    "url": "https://www.uniprot.org/uniprot/Q12986"
                }
            ],
            "common_name": "Human",
            "glygen_name": "Human",
            "reference_species": "Homo sapiens [9606]"
        }
    ],
    "mutagenesis": [
        {
            "start_pos": 621,
            "end_pos": 621,
            "sequence_org": "C",
            "sequence_mut": "S",
            "comment": "Loss of E2-dependent ubiquitination.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O00237",
                    "url": "https://www.uniprot.org/uniprot/O00237"
                },
                {
                    "database": "PubMed",
                    "id": "10500182",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10500182"
                }
            ],
            "uniprot_canonical_ac": "O00237-1"
        },
        {
            "start_pos": 134,
            "end_pos": 134,
            "sequence_org": "C",
            "sequence_mut": "S",
            "comment": "No E2 binding. Loss of ubiquitination activity.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9QZR0",
                    "url": "https://www.uniprot.org/uniprot/Q9QZR0"
                },
                {
                    "database": "PubMed",
                    "id": "10500182",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10500182"
                }
            ],
            "uniprot_canonical_ac": "Q9QZR0-1"
        },
        {
            "start_pos": 137,
            "end_pos": 137,
            "sequence_org": "C",
            "sequence_mut": "S",
            "comment": "No E2 binding. Loss of ubiquitination activity.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9QZR0",
                    "url": "https://www.uniprot.org/uniprot/Q9QZR0"
                },
                {
                    "database": "PubMed",
                    "id": "10500182",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10500182"
                }
            ],
            "uniprot_canonical_ac": "Q9QZR0-1"
        },
        {
            "start_pos": 152,
            "end_pos": 152,
            "sequence_org": "C",
            "sequence_mut": "S",
            "comment": "No E2 binding. Loss of ubiquitination activity.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9QZR0",
                    "url": "https://www.uniprot.org/uniprot/Q9QZR0"
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                    "id": "10500182",
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            ],
            "uniprot_canonical_ac": "Q9QZR0-1"
        },
        {
            "start_pos": 157,
            "end_pos": 157,
            "sequence_org": "H",
            "sequence_mut": "C",
            "comment": "No E2 binding. Loss of ubiquitination activity.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9QZR0",
                    "url": "https://www.uniprot.org/uniprot/Q9QZR0"
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                {
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                    "id": "10500182",
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            "uniprot_canonical_ac": "Q9QZR0-1"
        },
        {
            "start_pos": 158,
            "end_pos": 158,
            "sequence_org": "C",
            "sequence_mut": "S",
            "comment": "No E2 binding. Loss of ubiquitination activity.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9QZR0",
                    "url": "https://www.uniprot.org/uniprot/Q9QZR0"
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            "start_pos": 160,
            "end_pos": 160,
            "sequence_org": "C",
            "sequence_mut": "S",
            "comment": "No E2 binding. Loss of ubiquitination activity.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9QZR0",
                    "url": "https://www.uniprot.org/uniprot/Q9QZR0"
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            "start_pos": 553,
            "end_pos": 553,
            "sequence_org": "H",
            "sequence_mut": "S",
            "comment": "Loss of ubiquitination activity.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O55176",
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    "abstract": "",
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    "snv": [],
    "phosphorylation": [],
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