{
    "title": "Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activity.",
    "journal": "Oncogene",
    "date": "1999",
    "authors": "Choi S, Park S",
    "reference": {
        "type": "PubMed",
        "id": "10498895",
        "url": "https://pubmed.ncbi.nlm.nih.gov/10498895"
    },
    "referenced_glycans": [],
    "referenced_proteins": [
        {
            "uniprot_canonical_ac": "P29322-1",
            "protein_name": "Ephrin type-A receptor 8",
            "gene_name": "EPHA8",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P06241-1",
            "protein_name": "Tyrosine-protein kinase Fyn",
            "gene_name": "FYN",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "O09127-1",
            "protein_name": "Ephrin type-A receptor 8",
            "gene_name": "Epha8",
            "tax_name": "Mouse"
        }
    ],
    "species": [
        {
            "name": "Homo sapiens",
            "taxid": 9606,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P29322",
                    "url": "https://www.uniprot.org/uniprot/P29322"
                }
            ],
            "common_name": "Human",
            "glygen_name": "Human",
            "reference_species": "Homo sapiens [9606]"
        }
    ],
    "phosphorylation": [
        {
            "start_pos": 616,
            "end_pos": 616,
            "kinase_uniprot_canonical_ac": "P29322-1",
            "kinase_gene_name": "EPHA8",
            "residue": "Tyr",
            "comment": "",
            "evidence": [
                {
                    "database": "iPTMnet",
                    "id": "P29322",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P29322"
                },
                {
                    "database": "PubMed",
                    "id": "10498895",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10498895"
                },
                {
                    "database": "phospho.ELM",
                    "id": "P29322",
                    "url": "http://phospho.elm.eu.org/byAccession/P29322.html"
                }
            ],
            "site_lbl": "Tyr616",
            "uniprot_canonical_ac": "P29322-1"
        },
        {
            "start_pos": 839,
            "end_pos": 839,
            "kinase_uniprot_canonical_ac": "P29322-1",
            "kinase_gene_name": "EPHA8",
            "residue": "Tyr",
            "comment": "",
            "evidence": [
                {
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                    "id": "P29322",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P29322"
                },
                {
                    "database": "PubMed",
                    "id": "10498895",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10498895"
                },
                {
                    "database": "phospho.ELM",
                    "id": "P29322",
                    "url": "http://phospho.elm.eu.org/byAccession/P29322.html"
                }
            ],
            "site_lbl": "Tyr839",
            "uniprot_canonical_ac": "P29322-1"
        },
        {
            "start_pos": 615,
            "end_pos": 615,
            "kinase_uniprot_canonical_ac": "O09127-1",
            "kinase_gene_name": "Epha8",
            "residue": "Tyr",
            "comment": "",
            "evidence": [
                {
                    "database": "iPTMnet",
                    "id": "O09127",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O09127"
                },
                {
                    "database": "PubMed",
                    "id": "10498895",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10498895"
                },
                {
                    "database": "UniProtKB",
                    "id": "O09127",
                    "url": "https://www.uniprot.org/uniprot/O09127"
                }
            ],
            "site_lbl": "Tyr615",
            "uniprot_canonical_ac": "O09127-1"
        },
        {
            "start_pos": 615,
            "end_pos": 615,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Tyr",
            "comment": "Phosphotyrosine; by autocatalysis",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O09127",
                    "url": "https://www.uniprot.org/uniprot/O09127"
                },
                {
                    "database": "IntAct",
                    "id": "O09127",
                    "url": "https://www.ebi.ac.uk/intact/interactors/id:O09127*"
                },
                {
                    "database": "iPTMnet",
                    "id": "O09127",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O09127"
                },
                {
                    "database": "PubMed",
                    "id": "10498895",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10498895"
                }
            ],
            "site_lbl": "Tyr615",
            "uniprot_canonical_ac": "O09127-1"
        },
        {
            "start_pos": 838,
            "end_pos": 838,
            "kinase_uniprot_canonical_ac": "O09127-1",
            "kinase_gene_name": "Epha8",
            "residue": "Tyr",
            "comment": "",
            "evidence": [
                {
                    "database": "phospho.ELM",
                    "id": "O09127",
                    "url": "http://phospho.elm.eu.org/byAccession/O09127.html"
                },
                {
                    "database": "iPTMnet",
                    "id": "O09127",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O09127"
                },
                {
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                    "id": "10498895",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10498895"
                },
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                    "database": "UniProtKB",
                    "id": "O09127",
                    "url": "https://www.uniprot.org/uniprot/O09127"
                }
            ],
            "site_lbl": "Tyr838",
            "uniprot_canonical_ac": "O09127-1"
        }
    ],
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        {
            "start_pos": 615,
            "end_pos": 615,
            "sequence_org": "Y",
            "sequence_mut": "F",
            "comment": "Reduced phosphorylation and reduced association with FYN.",
            "evidence": [
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                    "database": "UniProtKB",
                    "id": "O09127",
                    "url": "https://www.uniprot.org/uniprot/O09127"
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                },
                {
                    "database": "PubMed",
                    "id": "11416136",
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            "uniprot_canonical_ac": "O09127-1"
        },
        {
            "start_pos": 838,
            "end_pos": 838,
            "sequence_org": "Y",
            "sequence_mut": "F",
            "comment": "Reduced tyrosine kinase activity.",
            "evidence": [
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                    "url": "https://www.uniprot.org/uniprot/O09127"
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    "abstract": "",
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    "snv": [],
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