{
    "title": "Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation.",
    "journal": "Nature",
    "date": "1999",
    "authors": "Sahara S, Aoto M, Eguchi Y, Imamoto N, Yoneda Y, Tsujimoto Y",
    "reference": {
        "type": "PubMed",
        "id": "10490026",
        "url": "https://pubmed.ncbi.nlm.nih.gov/10490026"
    },
    "referenced_glycans": [],
    "referenced_proteins": [
        {
            "uniprot_canonical_ac": "Q9UKV3-1",
            "protein_name": "Apoptotic chromatin condensation inducer in the nucleus",
            "gene_name": "ACIN1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9P289-1",
            "protein_name": "Serine/threonine-protein kinase 26",
            "gene_name": "STK26",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P49354-1",
            "protein_name": "Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha",
            "gene_name": "FNTA",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q05655-1",
            "protein_name": "Protein kinase C delta type",
            "gene_name": "PRKCD",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P51572-1",
            "protein_name": "B-cell receptor-associated protein 31",
            "gene_name": "BCAP31",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q13464-1",
            "protein_name": "Rho-associated protein kinase 1",
            "gene_name": "ROCK1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q01826-1",
            "protein_name": "DNA-binding protein SATB1",
            "gene_name": "SATB1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q14790-1",
            "protein_name": "Caspase-8",
            "gene_name": "CASP8",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P25054-1",
            "protein_name": "Adenomatous polyposis coli protein",
            "gene_name": "APC",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P55212-1",
            "protein_name": "Caspase-6",
            "gene_name": "CASP6",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9HAW4-1",
            "protein_name": "Claspin",
            "gene_name": "CLSPN",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P55210-1",
            "protein_name": "Caspase-7",
            "gene_name": "CASP7",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q13490-1",
            "protein_name": "Baculoviral IAP repeat-containing protein 2",
            "gene_name": "BIRC2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9Y6E0-1",
            "protein_name": "Serine/threonine-protein kinase 24",
            "gene_name": "STK24",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q04759-1",
            "protein_name": "Protein kinase C theta type",
            "gene_name": "PRKCQ",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P42574-1",
            "protein_name": "Caspase-3",
            "gene_name": "CASP3",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9JIX8-1",
            "protein_name": "Apoptotic chromatin condensation inducer in the nucleus",
            "gene_name": "Acin1",
            "tax_name": "Mouse"
        },
        {
            "uniprot_canonical_ac": "Q05397-1",
            "protein_name": "Focal adhesion kinase 1",
            "gene_name": "PTK2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P51813-1",
            "protein_name": "Cytoplasmic tyrosine-protein kinase BMX",
            "gene_name": "BMX",
            "tax_name": "Human"
        }
    ],
    "species": [
        {
            "name": "Homo sapiens",
            "taxid": 9606,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9UKV3",
                    "url": "https://www.uniprot.org/uniprot/Q9UKV3"
                }
            ],
            "common_name": "Human",
            "glygen_name": "Human",
            "reference_species": "Homo sapiens [9606]"
        }
    ],
    "mutagenesis": [
        {
            "start_pos": 1093,
            "end_pos": 1093,
            "sequence_org": "D",
            "sequence_mut": "A",
            "comment": "Abolishes cleavage by CASP3 and chromatin condensation activity.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9UKV3",
                    "url": "https://www.uniprot.org/uniprot/Q9UKV3"
                },
                {
                    "database": "PubMed",
                    "id": "10490026",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10490026"
                }
            ],
            "uniprot_canonical_ac": "Q9UKV3-1"
        }
    ],
    "record_id": "pubmed.10490026",
    "abstract": "",
    "glycosylation": [],
    "snv": [],
    "phosphorylation": [],
    "glycation": [],
    "section_stats": [
        {
            "table_id": "referenced_proteins",
            "table_stats": [
                {
                    "field": "total",
                    "count": 19
                }
            ],
            "sort_fields": [
                "uniprot_canonical_ac",
                "protein_name",
                "gene_name",
                "tax_name"
            ]
        },
        {
            "table_id": "referenced_glycans",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "phosphorylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported_with_glycan",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_predicted",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_automatic_literature_mining",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        }
    ]
}