{
    "title": "Characterization of the targeting, binding, and phosphorylation site domains of an A kinase anchor protein and a myristoylated alanine-rich C kinase substrate-like analog that are encoded by a single gene.",
    "journal": "The Journal of biological chemistry",
    "date": "1999",
    "authors": "Rossi EA, Li Z, Feng H, Rubin CS",
    "reference": {
        "type": "PubMed",
        "id": "10480937",
        "url": "https://pubmed.ncbi.nlm.nih.gov/10480937"
    },
    "referenced_glycans": [],
    "referenced_proteins": [
        {
            "uniprot_canonical_ac": "P62152-1",
            "protein_name": "Calmodulin",
            "gene_name": "Cam",
            "tax_name": "Fruit fly"
        },
        {
            "uniprot_canonical_ac": "Q9VLL3-1",
            "protein_name": "A-kinase anchor protein 200",
            "gene_name": "Akap200",
            "tax_name": "Fruit fly"
        }
    ],
    "species": [
        {
            "name": "Drosophila melanogaster",
            "taxid": 7227,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P62152",
                    "url": "https://www.uniprot.org/uniprot/P62152"
                }
            ],
            "common_name": "Fruit fly",
            "glygen_name": "Fruit fly",
            "reference_species": "Drosophila melanogaster [7227]"
        }
    ],
    "mutagenesis": [
        {
            "start_pos": 132,
            "end_pos": 132,
            "sequence_org": "S",
            "sequence_mut": "A",
            "comment": "Loss of phosphorylation by PKC. Overexpression in perineurial glia, results in reduced locomotor sensitization when first exposed to ethanol and ethanol tolerance following repeated exposure; when associated with A-135 and A-137.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9VLL3",
                    "url": "https://www.uniprot.org/uniprot/Q9VLL3"
                },
                {
                    "database": "PubMed",
                    "id": "10480937",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10480937"
                },
                {
                    "database": "PubMed",
                    "id": "29444420",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/29444420"
                }
            ],
            "uniprot_canonical_ac": "Q9VLL3-1"
        },
        {
            "start_pos": 135,
            "end_pos": 135,
            "sequence_org": "S",
            "sequence_mut": "A",
            "comment": "Partial loss of phosphorylation by PKC; when associated with A-137. Overexpression in perineurial glia, results in reduced locomotor sensitization when first exposed to ethanol and ethanol tolerance following repeated exposure; when associated with A-132 and A-137.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9VLL3",
                    "url": "https://www.uniprot.org/uniprot/Q9VLL3"
                },
                {
                    "database": "PubMed",
                    "id": "10480937",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10480937"
                },
                {
                    "database": "PubMed",
                    "id": "29444420",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/29444420"
                }
            ],
            "uniprot_canonical_ac": "Q9VLL3-1"
        },
        {
            "start_pos": 137,
            "end_pos": 137,
            "sequence_org": "S",
            "sequence_mut": "A",
            "comment": "Partial loss of phosphorylation by PKC; when associated with A-13A. Overexpression in perineurial glia, results in reduced locomotor sensitization when first exposed to ethanol and ethanol tolerance following repeated exposure; when associated with A-132 and A-135.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9VLL3",
                    "url": "https://www.uniprot.org/uniprot/Q9VLL3"
                },
                {
                    "database": "PubMed",
                    "id": "10480937",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10480937"
                },
                {
                    "database": "PubMed",
                    "id": "29444420",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/29444420"
                }
            ],
            "uniprot_canonical_ac": "Q9VLL3-1"
        },
        {
            "start_pos": 1,
            "end_pos": 7,
            "sequence_org": "MGKAQSK",
            "sequence_mut": "",
            "comment": "Loss of myristoylation. Overexpression in perineurial glia, leads to decreased ethanol sensitivity upon initial exposure and has no effect on ethanol tolerance following repeated exposure in contrast to overexpression of the wild-type form, possibly by delocalizing the protein from the membrane.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9VLL3",
                    "url": "https://www.uniprot.org/uniprot/Q9VLL3"
                },
                {
                    "database": "PubMed",
                    "id": "10480937",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10480937"
                },
                {
                    "database": "PubMed",
                    "id": "29444420",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/29444420"
                }
            ],
            "uniprot_canonical_ac": "Q9VLL3-1"
        },
        {
            "start_pos": 515,
            "end_pos": 515,
            "sequence_org": "A",
            "sequence_mut": "S",
            "comment": "Partial loss of binding to PKA-R2.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9VLL3",
                    "url": "https://www.uniprot.org/uniprot/Q9VLL3"
                },
                {
                    "database": "PubMed",
                    "id": "10480937",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10480937"
                }
            ],
            "uniprot_canonical_ac": "Q9VLL3-1"
        },
        {
            "start_pos": 518,
            "end_pos": 519,
            "sequence_org": "IV",
            "sequence_mut": "AA",
            "comment": "Loss of binding to PKA-R2.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9VLL3",
                    "url": "https://www.uniprot.org/uniprot/Q9VLL3"
                },
                {
                    "database": "PubMed",
                    "id": "10480937",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10480937"
                }
            ],
            "uniprot_canonical_ac": "Q9VLL3-1"
        },
        {
            "start_pos": 523,
            "end_pos": 523,
            "sequence_org": "T",
            "sequence_mut": "A",
            "comment": "Partial loss of binding to PKA-R2.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9VLL3",
                    "url": "https://www.uniprot.org/uniprot/Q9VLL3"
                },
                {
                    "database": "PubMed",
                    "id": "10480937",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10480937"
                }
            ],
            "uniprot_canonical_ac": "Q9VLL3-1"
        }
    ],
    "phosphorylation": [
        {
            "start_pos": 132,
            "end_pos": 132,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9VLL3",
                    "url": "https://www.uniprot.org/uniprot/Q9VLL3"
                },
                {
                    "database": "PubMed",
                    "id": "10480937",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10480937"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q9VLL3",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9VLL3"
                }
            ],
            "site_lbl": "Ser132",
            "uniprot_canonical_ac": "Q9VLL3-1"
        },
        {
            "start_pos": 135,
            "end_pos": 135,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9VLL3",
                    "url": "https://www.uniprot.org/uniprot/Q9VLL3"
                },
                {
                    "database": "PubMed",
                    "id": "10480937",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10480937"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q9VLL3",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9VLL3"
                }
            ],
            "site_lbl": "Ser135",
            "uniprot_canonical_ac": "Q9VLL3-1"
        },
        {
            "start_pos": 137,
            "end_pos": 137,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9VLL3",
                    "url": "https://www.uniprot.org/uniprot/Q9VLL3"
                },
                {
                    "database": "PubMed",
                    "id": "10480937",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10480937"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q9VLL3",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9VLL3"
                }
            ],
            "site_lbl": "Ser137",
            "uniprot_canonical_ac": "Q9VLL3-1"
        }
    ],
    "record_id": "pubmed.10480937",
    "abstract": "",
    "glycosylation": [],
    "snv": [],
    "glycation": [],
    "section_stats": [
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        {
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                },
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                {
                    "field": "n_linked_glycan_sites",
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                {
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                {
                    "field": "o_linked_glycan_sites",
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